SEQUENCE LISTING

<110>  MEDAREX, INC. and Oxford BioTherapeutics
 
<120>  FULLY HUMAN ANTIBODIES SPECIFIC TO CADM1

<130>  OTJ-002PC

<140>  New Application
<141>  Concurrently Herewith

<150>  61/209390
<151>  2009-03-05

<150>  61/209471
<151>  2009-03-05

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Ser Gly Val Gly Val Gly 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Ser Gly Val Gly Val Gly 
1               5           


<210>  3
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Ser Gly Val Gly Val Gly 
1               5           


<210>  4
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  5

Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  6

Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Arg Val Glu Trp Val Ala Leu Ala Gly Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Arg Val Glu Trp Phe Ala Leu Ala Gly Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Arg Val Glu Trp Val Thr Leu Ala Gly Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  11
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  12
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Ala Ser Ser Leu Gln Ser 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  19
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Asn Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Arg Arg Val Glu Trp Val Ala Leu Ala Gly Asn Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  20
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala His Arg Arg Val Glu Trp Phe Ala Leu Ala Gly Asn Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  21
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Arg Arg Val Glu Trp Val Thr Leu Ala Gly Asn Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  22
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  23
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  24
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  25
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  25
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcaat actagtggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt gcactcattt attgggacga tgataagcgc      180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacagg      300

agagttgaat gggtcgccct ggcagggaac tggttcgacc cctggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210>  26
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  26
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt gcactcattt attgggatga tgataagcgc      180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca tatattactg tgcgcacagg      300

agagttgagt ggttcgccct ggcagggaac tggttcgacc cctggggcca gggatccctg      360

gtcaccgtct cctca                                                       375


<210>  27
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  27
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcagt actagtggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt gcactcattt attgggacga tgataagcgc      180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacagg      300

agagttgagt gggtcaccct ggcagggaac tggttcgacc cctggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210>  28
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  28
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatggt gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcaa cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  29
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  29
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  30
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  30
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcaa cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  31
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Arg 
            100 


<210>  32
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Arg 
            100 


<210>  33
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  33

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Arg 
            100 


<210>  34
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95  


<210>  35
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95  


<210>  36
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95  


<210>  37
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  37

Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15      


<210>  38
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  38

Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15      


<210>  39
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  39

Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15      


<210>  40
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  41
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  41

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  42

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  43
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val 
            20                  25                  30          


Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln 
        35                  40                  45              


Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro 
    50                  55                  60                  


Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe 
                85                  90                  95      


Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr 
            100                 105                 110         


Val Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr 
        115                 120                 125             


Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser 
    130                 135                 140                 


Lys Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys 
145                 150                 155                 160 


Gly Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser 
                165                 170                 175     


Gln Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro Val Ile 
            180                 185                 190         


Cys Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg 
        195                 200                 205             


Tyr Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr 
    210                 215                 220                 


Pro Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys 
225                 230                 235                 240 


Glu Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val Arg Val 
                245                 250                 255     


Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe 
            260                 265                 270         


Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala 
        275                 280                 285             


Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr 
    290                 295                 300                 


Asp Ser Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp His Ala 
305                 310                 315                 320 


Val Ile Gly Gly Val Val Ala Val Val Val Phe Ala Met Leu Cys Leu 
                325                 330                 335     


Leu Ile Ile Leu Gly Arg Tyr Phe Ala Arg His Lys Gly Thr Tyr Phe 
            340                 345                 350         


Thr His Glu Ala Lys Gly Ala Asp Asp Ala Ala Asp Ala Asp Thr Ala 
        355                 360                 365             


Ile Ile Asn Ala Glu Gly Gly Gln Asn Asn Ser Glu Glu Lys Lys Glu 
    370                 375                 380                 


Tyr Phe Ile 
385         


<210>  44
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Thr Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val 
            20                  25                  30          


Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln 
        35                  40                  45              


Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro 
    50                  55                  60                  


Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe 
                85                  90                  95      


Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr 
            100                 105                 110         


Val Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr 
        115                 120                 125             


Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser 
    130                 135                 140                 


Lys Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys 
145                 150                 155                 160 


Gly Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser 
                165                 170                 175     


Gln Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro Val Ile 
            180                 185                 190         


Cys Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg 
        195                 200                 205             


Tyr Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr 
    210                 215                 220                 


Pro Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys 
225                 230                 235                 240 


Glu Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val Arg Val 
                245                 250                 255     


Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe 
            260                 265                 270         


Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala 
        275                 280                 285             


Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr 
    290                 295                 300                 


Asp Ser Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp Ala Ser 
305                 310                 315                 320 


His His His His His His 
                325     

<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>

<223>  Peptide conjugate
<400>  45
Pro Val Gly Val Val 
1               5   

