                         SEQUENCE LISTING

<110>  University of Rochester
       Sun, Jun
 
<120>  METHODS OF MODIFYING p53 ACETYLATION AND TREATING CANCER USING 
       AvrA

<130>  176-62701

<150>  61/156,718
<151>  2009-03-02

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  301
<212>  PRT
<213>  Salmonella enterica

<400>  1

Met Ile Phe Ser Val Gln Glu Leu Ser Cys Gly Gly Lys Ser Met Leu 
1               5                   10                  15      


Ser Pro Thr Thr Arg Asn Met Gly Ala Ser Leu Ser Pro Gln Pro Asp 
            20                  25                  30          


Val Ser Gly Glu Leu Asn Thr Glu Ala Leu Thr Cys Ile Val Glu Arg 
        35                  40                  45              


Leu Glu Ser Glu Ile Ile Asp Gly Ser Trp Ile His Ile Ser Tyr Glu 
    50                  55                  60                  


Glu Thr Asp Leu Glu Met Met Pro Phe Leu Val Ala Gln Ala Asn Lys 
65                  70                  75                  80  


Lys Tyr Pro Glu Leu Asn Leu Lys Phe Val Met Ser Val His Glu Leu 
                85                  90                  95      


Val Ser Ser Ile Lys Glu Thr Arg Met Glu Gly Val Glu Ser Ala Arg 
            100                 105                 110         


Phe Leu Val Asn Met Gly Ser Ser Gly Ile His Ile Ser Val Val Asp 
        115                 120                 125             


Phe Arg Val Met Asp Gly Lys Thr Ser Val Ile Leu Phe Glu Pro Ala 
    130                 135                 140                 


Ala Cys Ser Ala Phe Gly Pro Ala Leu Ala Leu Arg Thr Lys Ala Ala 
145                 150                 155                 160 


Leu Glu Arg Glu Gln Leu Pro Asp Cys Tyr Phe Ala Met Val Glu Leu 
                165                 170                 175     


Asp Ile Gln Arg Ser Ser Ser Glu Cys Gly Ile Phe Ser Leu Ala Leu 
            180                 185                 190         


Ala Lys Lys Leu Gln Leu Glu Phe Met Asn Leu Val Lys Ile His Glu 
        195                 200                 205             


Asp Asn Ile Cys Glu Arg Leu Cys Gly Glu Glu Pro Phe Leu Pro Ser 
    210                 215                 220                 


Asp Lys Ala Asp Arg Tyr Leu Pro Val Ser Phe Tyr Lys His Thr Gln 
225                 230                 235                 240 


Gly Ala Gln Arg Leu Asn Glu Tyr Val Glu Ala Asn Pro Ala Ala Gly 
                245                 250                 255     


Ser Ser Ile Val Asn Lys Lys Asn Glu Thr Leu Tyr Glu Arg Phe Asp 
            260                 265                 270         


Asn Asn Ala Val Met Leu Asn Asp Lys Lys Leu Ser Ile Ser Ala His 
        275                 280                 285             


Lys Lys Arg Ile Ala Glu Tyr Lys Ser Leu Leu Lys Pro 
    290                 295                 300     


<210>  2
<211>  302
<212>  PRT
<213>  Salmonella enterica

<400>  2

Met Ile Phe Ser Val Gln Glu Leu Ser Cys Gly Gly Lys Ser Met Leu 
1               5                   10                  15      


Ser Pro Thr Thr Arg Asn Met Gly Ala Ser Leu Ser Pro Gln Pro Asp 
            20                  25                  30          


Val Ser Gly Glu Leu Asn Thr Glu Ala Leu Thr Cys Ile Val Glu Arg 
        35                  40                  45              


Leu Glu Ser Glu Ile Ile Asp Gly Ser Trp Ile His Ile Ser Tyr Glu 
    50                  55                  60                  


Glu Thr Asp Leu Glu Met Met Pro Phe Leu Val Ala Gln Ala Asn Lys 
65                  70                  75                  80  


Lys Tyr Pro Glu Leu Asn Leu Lys Phe Val Met Ser Val His Glu Leu 
                85                  90                  95      


Val Ser Ser Ile Lys Glu Thr Arg Met Glu Gly Val Glu Ser Ala Arg 
            100                 105                 110         


Phe Leu Val Asn Met Gly Ser Ser Gly Ile His Ile Ser Val Val Asp 
        115                 120                 125             


Phe Arg Val Met Asp Gly Lys Thr Ser Val Ile Leu Phe Glu Pro Ala 
    130                 135                 140                 


Ala Cys Ser Ala Phe Gly Pro Ala Leu Leu Ala Leu Arg Thr Lys Ala 
145                 150                 155                 160 


Ala Leu Glu Arg Glu Gln Leu Pro Asp Cys Tyr Phe Ala Met Val Glu 
                165                 170                 175     


Leu Asp Ile Gln Arg Ser Ser Ser Glu Cys Gly Ile Phe Ser Leu Ala 
            180                 185                 190         


Leu Ala Lys Lys Leu Gln Leu Glu Phe Met Asn Leu Val Lys Ile His 
        195                 200                 205             


Glu Asp Asn Ile Cys Glu Arg Leu Cys Gly Glu Glu Pro Phe Leu Pro 
    210                 215                 220                 


Ser Asp Lys Ala Asp Arg Tyr Leu Pro Val Ser Phe Tyr Lys His Thr 
225                 230                 235                 240 


Gln Gly Ala Gln Arg Leu Asn Glu Tyr Val Glu Ala Asn Pro Ala Ala 
                245                 250                 255     


Gly Ser Ser Ile Val Asn Lys Lys Asn Glu Thr Leu Tyr Glu Arg Phe 
            260                 265                 270         


Asp Asn Asn Ala Val Met Leu Asn Asp Lys Lys Leu Ser Ile Ser Ala 
        275                 280                 285             


His Lys Lys Arg Ile Ala Glu Tyr Lys Ser Leu Leu Lys Pro 
    290                 295                 300         


<210>  3
<211>  302
<212>  PRT
<213>  Salmonella enterica

<400>  3

Met Ile Phe Ser Val Gln Glu Leu Ser Cys Gly Gly Lys Ser Met Leu 
1               5                   10                  15      


Ser Pro Thr Thr Arg Asn Met Gly Ala Ser Leu Ser Pro Gln Pro Asp 
            20                  25                  30          


Val Ser Gly Glu Leu Asn Thr Glu Ala Leu Thr Cys Ile Val Glu Arg 
        35                  40                  45              


Leu Glu Ser Glu Ile Ile Asp Gly Ser Trp Ile His Ile Ser Tyr Glu 
    50                  55                  60                  


Glu Thr Asp Leu Glu Met Met Pro Phe Leu Val Ala Gln Ala Asn Lys 
65                  70                  75                  80  


Lys Tyr Pro Glu Leu Asn Leu Lys Phe Val Met Ser Val His Glu Leu 
                85                  90                  95      


Val Ser Ser Ile Lys Glu Thr Arg Met Glu Gly Val Glu Ser Ala Arg 
            100                 105                 110         


Phe Leu Val Asn Met Gly Ser Ser Gly Ile His Ile Ser Val Val Asp 
        115                 120                 125             


Phe Arg Val Met Asp Gly Lys Thr Ser Val Ile Leu Phe Glu Pro Ala 
    130                 135                 140                 


Ala Cys Ser Ala Phe Gly Pro Ala Leu Leu Ala Leu Arg Thr Lys Ala 
145                 150                 155                 160 


Ala Leu Glu Arg Glu Gln Leu Pro Asp Cys Tyr Phe Ala Met Val Glu 
                165                 170                 175     


Leu Asp Ile Gln Arg Ser Ser Ser Glu Cys Gly Ile Phe Ser Leu Ala 
            180                 185                 190         


Leu Ala Lys Lys Leu Gln Leu Glu Phe Met Asn Leu Val Lys Ile His 
        195                 200                 205             


Glu Asp Asn Ile Cys Glu Arg Leu Cys Gly Glu Glu Pro Phe Leu Pro 
    210                 215                 220                 


Ser Asp Lys Ala Asp Arg Tyr Leu Pro Val Ser Phe Tyr Lys His Thr 
225                 230                 235                 240 


Gln Gly Val Gln Arg Leu Asn Glu Tyr Val Glu Ala Asn Pro Ala Ala 
                245                 250                 255     


Gly Ser Ser Ile Val Asn Lys Lys Asn Glu Thr Leu Tyr Glu Arg Phe 
            260                 265                 270         


Asp Asn Asn Ala Val Met Leu Asn Asp Lys Lys Leu Ser Ile Ser Ala 
        275                 280                 285             


His Lys Lys Arg Ile Ala Glu Tyr Lys Ser Leu Leu Lys Ser 
    290                 295                 300         


<210>  4
<211>  280
<212>  PRT
<213>  Salmonella enterica

<400>  4

Met Gly Ala Ser Leu Ser Pro Gln Pro Asp Val Ser Gly Glu Leu Asn 
1               5                   10                  15      


Thr Glu Ala Leu Thr Cys Ile Val Glu Arg Leu Glu Ser Glu Ile Ile 
            20                  25                  30          


Asp Gly Ser Trp Ile His Ile Ser Tyr Glu Glu Thr Asp Leu Glu Met 
        35                  40                  45              


Met Pro Phe Leu Val Ala Gln Ala Asn Lys Lys Tyr Pro Glu Leu Asn 
    50                  55                  60                  


Leu Lys Phe Val Met Ser Val His Glu Leu Val Ser Ser Ile Lys Glu 
65                  70                  75                  80  


Thr Arg Met Glu Gly Val Glu Ser Ala Arg Phe Leu Val Asn Met Gly 
                85                  90                  95      


Ser Ser Gly Ile His Ile Ser Val Val Asp Phe Arg Val Met Asp Gly 
            100                 105                 110         


Lys Thr Ser Val Ile Leu Phe Glu Pro Ala Ala Cys Ser Ala Phe Gly 
        115                 120                 125             


Pro Ala Leu Leu Ala Leu Arg Thr Lys Ala Ala Leu Glu Arg Glu Gln 
    130                 135                 140                 


Leu Pro Asp Cys Tyr Phe Ala Met Val Glu Leu Asp Ile Gln Arg Ser 
145                 150                 155                 160 


Ser Ser Glu Cys Gly Ile Phe Ser Leu Ala Leu Ala Lys Lys Leu Gln 
                165                 170                 175     


Leu Glu Phe Met Asn Leu Val Lys Ile His Glu Asp Asn Ile Cys Glu 
            180                 185                 190         


Arg Leu Cys Gly Glu Glu Pro Phe Leu Pro Ser Asp Lys Ala Asp Arg 
        195                 200                 205             


Tyr Leu Pro Val Ser Phe Tyr Lys His Thr Gln Gly Val Gln Arg Leu 
    210                 215                 220                 


Asn Glu Tyr Val Glu Ala Asn Pro Ala Ala Gly Ser Ser Ile Val Asn 
225                 230                 235                 240 


Lys Lys Asn Glu Thr Leu Tyr Glu Arg Phe Asp Asn Asn Ala Val Met 
                245                 250                 255     


Leu Asn Asp Lys Lys Leu Ser Ile Ser Ala His Lys Lys Arg Ile Ala 
            260                 265                 270         


Glu Tyr Lys Ser Leu Leu Lys Ser 
        275                 280 


<210>  5
<211>  302
<212>  PRT
<213>  Salmonella enterica

<400>  5

Met Ile Phe Ser Val Gln Glu Leu Ser Cys Gly Gly Lys Ser Met Leu 
1               5                   10                  15      


Ser Pro Thr Thr Arg Asn Met Gly Ala Ser Leu Ser Pro Gln Pro Asp 
            20                  25                  30          


Val Ser Gly Glu Leu Asn Thr Glu Ala Leu Thr Cys Ile Val Glu Arg 
        35                  40                  45              


Leu Glu Ser Glu Ile Ile Asp Gly Ser Trp Ile His Ile Ser Tyr Glu 
    50                  55                  60                  


Glu Thr Asp Leu Glu Met Met Pro Phe Leu Val Ala Gln Ala Asn Lys 
65                  70                  75                  80  


Lys Tyr Pro Glu Leu Asn Leu Lys Phe Val Met Ser Val His Glu Leu 
                85                  90                  95      


Val Ser Ser Ile Lys Glu Thr Arg Met Glu Gly Val Glu Ser Ala Arg 
            100                 105                 110         


Phe Leu Val Asn Met Gly Ser Ser Gly Ile His Ile Ser Val Val Asp 
        115                 120                 125             


Phe Arg Val Met Asp Gly Lys Thr Ser Val Ile Leu Phe Glu Pro Ala 
    130                 135                 140                 


Ala Cys Ser Ala Phe Gly Pro Ala Leu Leu Ala Leu Arg Thr Lys Ala 
145                 150                 155                 160 


Ala Leu Glu Arg Glu Gln Leu Pro Asp Cys Tyr Phe Ala Met Val Glu 
                165                 170                 175     


Leu Asp Ile Gln Arg Ser Ser Ser Glu Cys Gly Ile Phe Ser Leu Ala 
            180                 185                 190         


Leu Ala Lys Lys Leu Gln Leu Glu Phe Met Asn Leu Val Lys Ile His 
        195                 200                 205             


Glu Asp Asn Ile Cys Glu Arg Leu Cys Gly Glu Glu Pro Phe Leu Pro 
    210                 215                 220                 


Ser Asp Lys Ala Asp Arg Tyr Leu Pro Val Ser Phe Tyr Lys His Thr 
225                 230                 235                 240 


Gln Gly Val Gln Arg Leu Asn Glu Tyr Val Glu Ala Asn Pro Ala Ala 
                245                 250                 255     


Gly Ser Ser Ile Val Asn Lys Lys Asn Glu Thr Leu Tyr Glu Arg Phe 
            260                 265                 270         


Asp Asn Asn Ala Val Met Leu Asn Asp Lys Lys Leu Ser Ile Ser Ala 
        275                 280                 285             


His Lys Lys Arg Ile Ala Glu Tyr Lys Ser Leu Leu Lys Ser 
    290                 295                 300         


<210>  6
<211>  280
<212>  PRT
<213>  Salmonella enterica

<400>  6

Met Gly Ala Ser Leu Ser Pro Gln Pro Asp Val Ser Gly Glu Leu Asn 
1               5                   10                  15      


Thr Glu Ala Leu Thr Cys Ile Val Glu Arg Leu Glu Ser Glu Ile Ile 
            20                  25                  30          


Asp Gly Ser Trp Ile His Ile Ser Tyr Glu Glu Thr Asp Leu Glu Met 
        35                  40                  45              


Met Pro Phe Leu Val Ala Gln Ala Asn Lys Lys Tyr Pro Glu Leu Asn 
    50                  55                  60                  


Leu Lys Phe Val Met Ser Val His Glu Leu Val Ser Ser Ile Lys Glu 
65                  70                  75                  80  


Thr Arg Met Glu Gly Val Glu Ser Ala Arg Phe Leu Val Asn Met Gly 
                85                  90                  95      


Ser Ser Gly Ile His Ile Ser Val Val Asp Phe Arg Val Met Asp Gly 
            100                 105                 110         


Lys Thr Ser Val Ile Leu Phe Glu Pro Ala Ala Cys Ser Ala Phe Gly 
        115                 120                 125             


Pro Ala Leu Leu Ala Leu Arg Thr Lys Ala Ala Leu Glu Arg Glu Gln 
    130                 135                 140                 


Leu Pro Asp Cys Tyr Phe Ala Met Val Glu Leu Asp Ile Gln Arg Ser 
145                 150                 155                 160 


Ser Ser Glu Cys Gly Ile Phe Ser Leu Ala Leu Ala Lys Lys Leu Gln 
                165                 170                 175     


Leu Glu Phe Met Asn Leu Val Lys Ile His Glu Asp Asn Ile Cys Glu 
            180                 185                 190         


Arg Leu Cys Gly Glu Glu Pro Phe Leu Pro Ser Asp Lys Ala Asp Arg 
        195                 200                 205             


Tyr Leu Pro Val Ser Phe Tyr Lys His Thr Gln Gly Val Gln Arg Leu 
    210                 215                 220                 


Asn Glu Tyr Val Glu Ala Asn Pro Ala Ala Gly Ser Ser Ile Val Asn 
225                 230                 235                 240 


Lys Lys Asn Glu Thr Leu Tyr Glu Arg Phe Asp Asn Asn Ala Val Met 
                245                 250                 255     


Leu Asn Asp Lys Lys Leu Ser Ile Ser Ala His Lys Lys Arg Ile Ala 
            260                 265                 270         


Glu Tyr Lys Ser Leu Leu Lys Pro 
        275                 280 


<210>  7
<211>  288
<212>  PRT
<213>  Salmonella enterica

<400>  7

Met Leu Ser Pro Thr Thr Arg Asn Met Gly Ala Ser Leu Ser Pro Gln 
1               5                   10                  15      


Pro Asp Val Ser Gly Glu Leu Asn Thr Glu Ala Leu Thr Cys Ile Val 
            20                  25                  30          


Glu Arg Leu Glu Ser Glu Ile Ile Asp Gly Ser Trp Ile His Ile Ser 
        35                  40                  45              


Tyr Glu Glu Thr Asp Leu Glu Met Met Pro Phe Leu Val Ala Gln Ala 
    50                  55                  60                  


Asn Lys Lys Tyr Pro Glu Leu Asn Leu Lys Phe Val Met Ser Val His 
65                  70                  75                  80  


Glu Leu Val Ser Ser Ile Lys Glu Thr Arg Met Glu Gly Val Glu Ser 
                85                  90                  95      


Ala Arg Phe Leu Val Asn Met Gly Ser Ser Gly Ile His Ile Ser Val 
            100                 105                 110         


Val Asp Phe Arg Val Met Asp Gly Lys Thr Ser Val Ile Leu Phe Glu 
        115                 120                 125             


Pro Ala Ala Cys Ser Ala Phe Gly Pro Ala Leu Leu Ala Leu Arg Thr 
    130                 135                 140                 


Lys Ala Ala Leu Glu Arg Glu Gln Leu Pro Asp Cys Tyr Phe Ala Met 
145                 150                 155                 160 


Val Glu Leu Asp Ile Gln Arg Ser Ser Ser Glu Cys Gly Ile Phe Ser 
                165                 170                 175     


Leu Ala Leu Ala Lys Lys Leu Gln Leu Glu Phe Met Asn Leu Val Lys 
            180                 185                 190         


Ile His Glu Asp Asn Ile Cys Glu Arg Leu Cys Gly Glu Glu Pro Phe 
        195                 200                 205             


Leu Pro Ser Asp Lys Ala Asp Arg Tyr Leu Pro Val Ser Phe Tyr Lys 
    210                 215                 220                 


His Thr Gln Gly Val Gln Arg Leu Asn Glu Tyr Val Glu Ala Asn Pro 
225                 230                 235                 240 


Ala Ala Gly Ser Ser Ile Val Asn Lys Lys Asn Glu Thr Leu Tyr Glu 
                245                 250                 255     


Arg Phe Asp Asn Asn Ala Val Met Leu Asn Asp Lys Lys Leu Ser Ile 
            260                 265                 270         


Phe Ala His Lys Lys Arg Ile Ala Glu Tyr Lys Ser Leu Leu Lys Pro 
        275                 280                 285             


<210>  8
<211>  288
<212>  PRT
<213>  Salmonella enterica

<400>  8

Met Leu Ser Pro Thr Thr Arg Asn Met Gly Ala Ser Leu Ser Pro Gln 
1               5                   10                  15      


Pro Asp Val Ser Gly Glu Leu Asn Thr Glu Ala Leu Thr Cys Ile Val 
            20                  25                  30          


Glu Arg Leu Glu Ser Glu Ile Ile Asp Gly Ser Trp Ile His Ile Ser 
        35                  40                  45              


Tyr Glu Glu Thr Asp Leu Glu Met Met Pro Phe Leu Val Ala Gln Ala 
    50                  55                  60                  


Asn Lys Lys Tyr Pro Glu Leu Asn Leu Lys Phe Val Met Ser Val His 
65                  70                  75                  80  


Glu Leu Val Ser Ser Ile Lys Glu Thr Arg Met Glu Gly Val Glu Ser 
                85                  90                  95      


Ala Arg Phe Leu Val Asn Met Gly Ser Ser Gly Ile His Ile Ser Val 
            100                 105                 110         


Val Asp Phe Arg Val Met Asp Gly Lys Thr Ser Val Ile Leu Phe Glu 
        115                 120                 125             


Pro Ala Ala Cys Ser Ala Phe Gly Pro Ala Leu Leu Ala Leu Arg Thr 
    130                 135                 140                 


Lys Ala Ala Leu Glu Arg Glu Gln Leu Pro Asp Cys Tyr Phe Ala Met 
145                 150                 155                 160 


Val Glu Leu Asp Ile Gln Arg Ser Ser Ser Glu Cys Gly Ile Phe Ser 
                165                 170                 175     


Leu Ala Leu Ala Lys Lys Leu Gln Leu Glu Phe Met Asn Leu Val Lys 
            180                 185                 190         


Ile His Glu Asp Asn Ile Cys Glu Arg Leu Cys Gly Glu Glu Pro Phe 
        195                 200                 205             


Leu Pro Ser Asp Lys Ala Asp Arg Tyr Leu Pro Val Ser Phe Tyr Lys 
    210                 215                 220                 


His Thr Gln Gly Val Gln Arg Leu Asn Glu Tyr Val Gln Ala Asn Pro 
225                 230                 235                 240 


Ala Ala Gly Ser Ser Ile Val Asn Lys Lys Asn Glu Thr Leu Tyr Glu 
                245                 250                 255     


Arg Phe Asp Asn Asn Ala Val Met Leu Asn Asp Lys Lys Leu Ser Ile 
            260                 265                 270         


Ser Ala His Lys Lys Arg Ile Ala Glu Tyr Lys Ser Leu Leu Lys Pro 
        275                 280                 285             


<210>  9
<211>  288
<212>  PRT
<213>  Salmonella enterica

<400>  9

Met Leu Ser Pro Thr Thr Arg Asn Met Gly Ala Ser Leu Ser Pro Gln 
1               5                   10                  15      


Ser Asp Val Ser Gly Glu Leu Asn Thr Glu Ala Leu Thr Cys Ile Val 
            20                  25                  30          


Glu Arg Leu Glu Ser Glu Ile Ile Asp Gly Ser Trp Ile His Ile Ser 
        35                  40                  45              


Tyr Glu Glu Thr Asp Leu Glu Met Met Pro Phe Leu Val Ala Gln Ala 
    50                  55                  60                  


Asn Lys Lys Tyr Pro Glu Leu Asn Leu Lys Phe Val Met Ser Val His 
65                  70                  75                  80  


Glu Leu Val Ser Ser Ile Lys Glu Thr Arg Met Glu Gly Val Glu Ser 
                85                  90                  95      


Ala Arg Phe Ile Val Asn Met Gly Ser Ser Gly Ile His Val Ser Val 
            100                 105                 110         


Val Asp Phe Arg Val Met Asp Gly Lys Thr Ser Val Ile Leu Phe Glu 
        115                 120                 125             


Pro Ala Ala Cys Ser Ala Phe Gly Pro Ala Leu Leu Ala Leu Arg Thr 
    130                 135                 140                 


Lys Ala Ala Leu Glu Arg Glu Gln Leu Pro Asp Cys Tyr Phe Ala Met 
145                 150                 155                 160 


Val Glu Leu Asp Ile Gln Arg Ser Ser Ser Glu Cys Gly Ile Phe Ser 
                165                 170                 175     


Leu Ala Leu Ala Lys Lys Leu His Leu Glu Phe Met Asn Leu Val Lys 
            180                 185                 190         


Ile His Glu Asp Asn Ile Cys Glu Arg Leu Cys Gly Glu Glu Pro Phe 
        195                 200                 205             


Leu Pro Ser Asp Lys Ala Asp Arg Tyr Leu Pro Val Ser Phe Tyr Lys 
    210                 215                 220                 


His Thr Gln Gly Val Gln Arg Leu Asn Glu Tyr Val Gln Ala Asn Pro 
225                 230                 235                 240 


Ala Ala Gly Ser Ser Ile Val Asn Lys Lys Asn Glu Thr Leu Tyr Glu 
                245                 250                 255     


Arg Phe Asp Asn Asn Ala Val Met Leu Asn Asp Lys Lys Leu Ser Ile 
            260                 265                 270         


Ser Ala His Lys Lys Arg Ile Ala Glu Tyr Lys Ser Leu Leu Lys Pro 
        275                 280                 285             


<210>  10
<211>  906
<212>  DNA
<213>  Salmonella enterica

<400>  10
atgatatttt cggtgcagga gctatcatgt ggagggaaaa gtatgctaag tcctacgact       60

cgtaatatgg gggcgagttt atcgcctcag cctgacgtca gcggggagct aaacaccgaa      120

gcattgacct gtattgttga gcgtctggaa agtgaaatta tagatggcag ctggattcat      180

atcagttacg aggaaaccga tctcgaaatg atgccttttc ttgttgcaca ggccaataag      240

aagtatccag agttaaatct taaatttgtt atgtcagtcc atgagcttgt ttcctctata      300

aaggagacca gaatggaagg cgttgaatct gcccgatttc tcgtaaatat gggaagttca      360

ggtatccata tttcagtcgt cgattttaga gttatggacg gaaagacatc ggtgattttg      420

ttcgaaccag cagcgtgtag cgcttttgga cctgcactgg cgttgaggac caaagcagct      480

cttgaacgtg aacaactgcc tgattgttat tttgctatgg tcgagctgga cattcaacga      540

agctcttctg aatgcggtat ttttagcctg gcgctcgcca aaaaacttca gcttgaattt      600

atgaacttag taaaaattca tgaagataat atttgtgaac gtctgtgtgg tgaagaacct      660

tttctcccgt ccgataaagc agaccgctat ctgccggtga gtttttacaa acatactcaa      720

ggcgcacaac gattaaatga atatgtggag gccaatccgg cggcgggaag cagtatagta      780

aacaaaaaga atgaaacgct ttatgagcga ttcgataaca atgccgttat gctaaacgat      840

aaaaaactct ctatatccgc tcataaaaaa aggatagctg aatataagtc tttacttaaa      900

ccgtaa                                                                 906


<210>  11
<211>  909
<212>  DNA
<213>  Salmonella enterica

<400>  11
atgatatttt cggtgcagga gctatcatgt ggagggaaaa gtatgctaag tcctacgact       60

cgtaatatgg gggcgagttt atcgcctcag cctgacgtca gcggggagct aaacaccgaa      120

gcattgacct gtattgttga gcgtctggaa agtgaaatta tagatggcag ctggattcat      180

atcagttacg aggaaaccga tctcgaaatg atgccttttc ttgttgcaca ggccaataag      240

aagtatccag agttaaatct taaatttgtt atgtcagtcc atgagcttgt ttcctctata      300

aaggagacca gaatggaagg cgttgaatct gcccgatttc tcgtaaatat gggaagttca      360

ggtatccata tttcagtcgt cgattttaga gttatggacg gaaagacatc ggtgattttg      420

ttcgaaccag cagcgtgtag cgcttttgga cctgctttac tggcgttgag gaccaaagca      480

gctcttgaac gtgaacaact gcctgattgt tattttgcta tggtcgagct ggacattcaa      540

cgaagctctt ctgaatgcgg tatttttagc ctggcgctcg ccaaaaaact tcagcttgaa      600

tttatgaact tagtaaaaat tcatgaagat aatatttgtg aacgtctgtg tggtgaagaa      660

ccttttctcc cgtccgataa agcagaccgc tatctgccgg tgagttttta caaacatact      720

caaggcgcac aacgattaaa tgaatatgtg gaggccaatc cggcggcggg aagcagtata      780

gtaaacaaaa agaatgaaac gctttatgag cgattcgata acaatgccgt tatgctaaac      840

gataaaaaac tctctatatc cgctcataaa aaaaggatag ctgaatataa gtctttactt      900

aaaccgtaa                                                              909


<210>  12
<211>  909
<212>  DNA
<213>  Salmonella enterica

<400>  12
atgatatttt cggtgcagga gctatcatgt ggagggaaaa gtatgctaag tcctacgact       60

cgtaatatgg gggcgagttt atcgcctcag cctgacgtca gcggggagct aaacaccgaa      120

gcattgacct gtattgttga gcgtctggaa agtgaaatta tagatggcag ctggattcat      180

atcagttacg aggaaaccga tctcgaaatg atgccttttc ttgttgcaca ggccaataag      240

aagtatccag agttaaatct taaatttgtt atgtcagtcc atgagcttgt ttcctctata      300

aaggagacca gaatggaagg cgttgaatct gcccgatttc tcgtaaatat gggaagttca      360

ggtatccata tttcagtcgt cgattttaga gttatggacg gaaagacatc ggtgattttg      420

ttcgaaccag cagcgtgtag cgcttttgga cctgctttac tggcgttgag gaccaaagca      480

gctcttgaac gtgaacaact gcctgattgt tattttgcta tggtcgagct ggacattcaa      540

cgaagctctt ctgaatgcgg tatttttagc ctggcgctcg ccaaaaaact tcagcttgaa      600

tttatgaact tagtaaaaat tcatgaagat aatatttgtg aacgtctgtg tggtgaagaa      660

ccttttctcc cgtccgataa agcagaccgt tatctgccgg tgagttttta caaacatact      720

caaggcgtac aacgattaaa tgaatatgtg gaggccaatc cggcggcggg aagcagtata      780

gtaaacaaaa agaatgaaac gctttatgag cgattcgata acaatgccgt tatgctaaac      840

gataaaaaac tctctatatc cgctcataaa aaaaggatag ctgaatataa gtctttactt      900

aaatcgtaa                                                              909


<210>  13
<211>  843
<212>  DNA
<213>  Salmonella enterica

<400>  13
atgggggcga gtttatcgcc tcagcctgac gtcagcgggg agctaaacac cgaagcattg       60

acctgtattg ttgagcgtct ggaaagtgaa attatagatg gcagctggat tcatatcagt      120

tacgaggaaa ccgatctcga aatgatgcct tttcttgttg cacaggccaa taagaagtat      180

ccagagttaa atcttaaatt tgttatgtca gtccatgagc ttgtttcctc tataaaggag      240

accagaatgg aaggcgttga atctgcccga tttctcgtaa atatgggaag ttcaggtatc      300

catatttcag tcgtcgattt tagagttatg gacggaaaga catcggtgat tttgttcgaa      360

ccagcagcgt gtagcgcttt tggacctgct ttactggcgt tgaggaccaa agcagctctt      420

gaacgtgaac aactgcctga ttgttatttt gctatggtcg agctggacat tcaacgaagc      480

tcttctgaat gcggtatttt tagcctggcg ctcgccaaaa aacttcagct tgaatttatg      540

aacttagtaa aaattcatga agataatatt tgtgaacgtc tgtgtggtga agaacctttt      600

ctcccgtccg ataaagcaga ccgttatctg ccggtgagtt tttacaaaca tactcaaggc      660

gtacaacgat taaatgaata tgtggaggcc aatccggcgg cgggaagcag tatagtaaac      720

aaaaagaatg aaacgcttta tgagcgattc gataacaatg ccgttatgct aaacgataaa      780

aaactctcta tatccgctca taaaaaaagg atagctgaat ataagtcttt acttaaatcg      840

taa                                                                    843


<210>  14
<211>  909
<212>  DNA
<213>  Salmonella enterica

<400>  14
atgatatttt cggtgcagga gctatcatgt ggagggaaaa gtatgctaag tcctacgact       60

cgtaatatgg gggcgagttt atcgcctcag cctgacgtca gcggggagct aaacaccgaa      120

gcattgacct gtattgttga gcgtctggaa agtgaaatta tagatggcag ctggattcat      180

atcagttacg aggaaaccga tctcgaaatg atgccttttc ttgttgcaca ggccaataag      240

aagtatccag agttaaatct taaatttgtt atgtcagtcc atgagcttgt ttcctctata      300

aaggagacca gaatggaagg cgttgaatct gcccgatttc tcgtaaatat gggaagttca      360

ggtatccata tttcagtcgt cgattttaga gttatggacg gaaagacatc ggtgattttg      420

ttcgaaccag cagcgtgtag cgcttttgga cctgctttac tggcgttgag gaccaaagca      480

gctcttgaac gtgaacaact gcctgattgt tattttgcta tggtcgagct ggacattcaa      540

cgaagctctt ctgaatgcgg tatttttagc ctggcgctcg ccaaaaaact tcagcttgaa      600

tttatgaact tagtaaaaat tcatgaagat aatatttgtg aacgtctgtg tggtgaagaa      660

ccttttctcc cgtccgataa agcagaccgt tatctgccgg tgagttttta caaacatact      720

caaggcgtac aacgattaaa tgaatatgtg gaggccaatc cggcggcggg aagcagtata      780

gtaaacaaaa agaatgaaac gctttatgag cgattcgata acaatgccgt tatgctaaac      840

gataaaaaac tctctatatc cgctcataaa aaaaggatag ctgaatataa gtctttactt      900

aaatcgtaa                                                              909


<210>  15
<211>  843
<212>  DNA
<213>  Salmonella enterica

<400>  15
atgggggcga gtttatcgcc tcagcctgac gtcagcgggg agctaaacac cgaagcattg       60

acctgtattg ttgagcgtct ggaaagtgaa attatagatg gcagctggat tcatatcagt      120

tacgaggaaa ccgatctcga aatgatgcct tttcttgttg cacaggccaa taagaagtat      180

ccagagttaa atcttaaatt tgttatgtca gtccatgagc ttgtttcctc tataaaggag      240

accagaatgg aaggcgttga atctgcccga tttctcgtaa atatgggaag ttcaggtatc      300

catatttcag tcgtcgattt tagagttatg gacggaaaga catcggtgat tttgttcgaa      360

ccagcagcgt gtagcgcttt tggacctgct ttactggcgt tgaggaccaa agcagctctt      420

gaacgtgaac aactgcctga ttgttatttt gctatggtcg agctggacat tcaacgaagc      480

tcttctgaat gcggtatttt tagcctggcg ctcgccaaaa aacttcagct tgaatttatg      540

aacttagtaa aaattcatga agataatatt tgtgaacgtc tgtgtggtga agaacctttt      600

ctcccgtccg ataaagcaga ccgctatctg ccggtgagtt tttacaaaca tactcaaggc      660

gtacaacgat taaatgaata tgtggaggcc aatccggcgg cgggaagcag tatagtaaac      720

aaaaagaatg aaacgcttta tgagcgattc gataacaatg ccgttatgct aaacgataaa      780

aaactctcta tatccgctca taaaaaaagg atagctgaat ataagtcttt acttaaaccg      840

taa                                                                    843


<210>  16
<211>  867
<212>  DNA
<213>  Salmonella enterica

<400>  16
atgctaagtc ctacgactcg taatatgggg gcgagtttat cgcctcagcc tgacgtcagc       60

ggggagctaa acaccgaagc attgacctgt attgttgagc gtctggaaag tgaaattata      120

gatggcagct ggattcatat cagttacgag gaaaccgatc tcgaaatgat gccttttctt      180

gttgcacagg ccaataagaa gtatccagag ttaaatctta aatttgttat gtcagtccat      240

gagcttgttt cctctataaa ggagaccaga atggaaggcg ttgaatctgc ccgatttctc      300

gtaaatatgg gaagttcagg tatccatatt tcagtcgtcg attttagagt tatggacgga      360

aagacatcgg tgattttgtt cgaaccagca gcgtgtagcg cttttggacc tgctttactg      420

gcgttgagga ccaaagcagc tcttgaacgt gaacaactgc ctgattgtta ttttgctatg      480

gtcgagctgg acattcaacg aagctcttct gaatgcggta tttttagcct ggcgctcgcc      540

aaaaaacttc agcttgaatt tatgaactta gtaaaaattc atgaagataa tatttgtgaa      600

cgtctgtgtg gtgaagaacc ttttctcccg tccgataaag cagaccgcta tctgccggtg      660

agtttttaca aacatactca aggcgtacaa cgattaaatg aatatgtgga ggccaatccg      720

gcggcgggaa gcagtatagt aaacaaaaag aatgaaacgc tttatgagcg attcgataac      780

aatgccgtta tgctaaacga taaaaaactc tctatattcg ctcataaaaa aaggatagct      840

gaatataagt ctttacttaa accgtaa                                          867


<210>  17
<211>  867
<212>  DNA
<213>  Salmonella enterica

<400>  17
atgctaagtc ctacgactcg taatatgggg gcgagtttat cgcctcagcc tgacgtcagc       60

ggggagctaa acaccgaagc attgacctgt attgttgagc gtctggaaag tgaaattata      120

gatggcagct ggattcatat cagttacgag gaaaccgatc tcgaaatgat gccttttctt      180

gttgcacagg ccaataagaa gtatccagag ttaaatctta aatttgttat gtcagtccat      240

gagcttgttt cctctataaa ggagaccaga atggaaggcg ttgaatctgc ccgatttctc      300

gtaaatatgg gaagttcagg tatccatatt tcagtcgtcg attttagagt tatggacgga      360

aagacatcgg tgattttgtt cgaaccagca gcgtgtagcg cttttggacc tgctttactg      420

gcgttgagga ccaaagcagc tcttgaacgt gaacaactgc ctgattgtta ttttgctatg      480

gtcgagctgg acattcaacg aagctcttct gaatgtggta tttttagcct ggcgctcgcc      540

aaaaaacttc agcttgaatt tatgaactta gtaaaaattc atgaagataa tatttgtgaa      600

cgtctgtgtg gtgaagaacc ttttctcccg tctgataaag cagaccgtta tctgccggtg      660

agtttttaca aacatactca aggcgtacaa cgattaaatg aatatgtgca ggccaatccg      720

gcggcgggaa gcagtatagt aaacaaaaag aatgaaacgc tttatgagcg attcgataac      780

aatgccgtta tgctaaacga taaaaaactc tctatatccg ctcataaaaa aaggatagct      840

gaatataagt ctttgcttaa accgtaa                                          867


<210>  18
<211>  867
<212>  DNA
<213>  Salmonella enterica

<400>  18
atgctaagtc ctacgactcg taatatgggg gcgagtttat cgcctcagtc tgacgtcagc       60

ggggagctaa acaccgaagc attgacctgt attgttgagc gtctggaaag tgaaattata      120

gatggcagct ggattcatat cagttacgag gaaaccgatc tcgaaatgat gccttttctt      180

gttgcacagg ccaataagaa gtatccagag ttaaatctta aatttgttat gtcagtccat      240

gagcttgttt cctctataaa ggagaccaga atggaaggcg ttgaatctgc ccgatttatc      300

gtaaatatgg gaagttcagg tatccatgtt tcagtcgtcg attttagagt tatggacgga      360

aagacatcgg tgattttgtt cgaaccagca gcgtgtagcg cttttggacc tgctttactg      420

gcattgagga ccaaagcagc tcttgaacgt gaacaattgc ctgattgtta ttttgctatg      480

gtcgagctgg acattcaacg aagctcttct gaatgcggta tttttagcct ggcgctcgcc      540

aaaaaacttc atcttgaatt tatgaactta gtaaaaattc atgaagataa tatttgtgaa      600

cgtctgtgtg gtgaagaacc ttttctcccg tccgataaag cagaccgcta tctgccggtg      660

agtttttaca aacatactca aggcgtacaa cgattaaatg aatatgtgca ggccaatccg      720

gcggcgggaa gcagtatagt aaacaaaaag aatgaaacgc tttatgagcg attcgataac      780

aatgccgtta tgctaaacga taaaaaactc tctatatccg ctcataaaaa aaggatagct      840

gaatataagt ctttacttaa accgtaa                                          867


<210>  19
<211>  302
<212>  PRT
<213>  Artificial

<220>
<223>  AvrA consensus


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (124)..(124)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (153)..(153)
<223>  Xaa is optional and can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (198)..(198)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (243)..(243)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (251)..(251)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (287)..(287)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (302)..(302)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Met Ile Phe Ser Val Gln Glu Leu Ser Cys Gly Gly Lys Ser Met Leu 
1               5                   10                  15      


Ser Pro Thr Thr Arg Asn Met Gly Ala Ser Leu Ser Pro Gln Xaa Asp 
            20                  25                  30          


Val Ser Gly Glu Leu Asn Thr Glu Ala Leu Thr Cys Ile Val Glu Arg 
        35                  40                  45              


Leu Glu Ser Glu Ile Ile Asp Gly Ser Trp Ile His Ile Ser Tyr Glu 
    50                  55                  60                  


Glu Thr Asp Leu Glu Met Met Pro Phe Leu Val Ala Gln Ala Asn Lys 
65                  70                  75                  80  


Lys Tyr Pro Glu Leu Asn Leu Lys Phe Val Met Ser Val His Glu Leu 
                85                  90                  95      


Val Ser Ser Ile Lys Glu Thr Arg Met Glu Gly Val Glu Ser Ala Arg 
            100                 105                 110         


Phe Xaa Val Asn Met Gly Ser Ser Gly Ile His Xaa Ser Val Val Asp 
        115                 120                 125             


Phe Arg Val Met Asp Gly Lys Thr Ser Val Ile Leu Phe Glu Pro Ala 
    130                 135                 140                 


Ala Cys Ser Ala Phe Gly Pro Ala Xaa Leu Ala Leu Arg Thr Lys Ala 
145                 150                 155                 160 


Ala Leu Glu Arg Glu Gln Leu Pro Asp Cys Tyr Phe Ala Met Val Glu 
                165                 170                 175     


Leu Asp Ile Gln Arg Ser Ser Ser Glu Cys Gly Ile Phe Ser Leu Ala 
            180                 185                 190         


Leu Ala Lys Lys Leu Xaa Leu Glu Phe Met Asn Leu Val Lys Ile His 
        195                 200                 205             


Glu Asp Asn Ile Cys Glu Arg Leu Cys Gly Glu Glu Pro Phe Leu Pro 
    210                 215                 220                 


Ser Asp Lys Ala Asp Arg Tyr Leu Pro Val Ser Phe Tyr Lys His Thr 
225                 230                 235                 240 


Gln Gly Xaa Gln Arg Leu Asn Glu Tyr Val Xaa Ala Asn Pro Ala Ala 
                245                 250                 255     


Gly Ser Ser Ile Val Asn Lys Lys Asn Glu Thr Leu Tyr Glu Arg Phe 
            260                 265                 270         


Asp Asn Asn Ala Val Met Leu Asn Asp Lys Lys Leu Ser Ile Xaa Ala 
        275                 280                 285             


His Lys Lys Arg Ile Ala Glu Tyr Lys Ser Leu Leu Lys Xaa 
    290                 295                 300         


<210>  20
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer for IL-8

<400>  20
tgcataaaga catactccaa acct                                              24


<210>  21
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer for IL-8

<400>  21
aattctcagc cctcttcaaa aa                                                22


<210>  22
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer for GAPDH

<400>  22
cttcaccacc atggagaagg c                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer for GAPDH

<400>  23
ggcatggact gtggtcatga g                                                 21


<210>  24
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  hemagglutinin tag

<400>  24

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


