
                                SEQUENCE LISTING

<110> Vignali, Dario AA
      Collison, Lauren W.

<120> COMPOSITIONS AND METHODS FOR GENERATING
  INTERLEUKIN-35-INDUCED REGULATORY T CELLS
  

<130> 44158/384646

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1169
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (8)...(694)

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> Human EBI3 from GenBank BC0046112

<400> 1
cgcagcc atg acc ccg cag ctt ctc ctg gcc ctt gtc ctc tgg gcc agc   49
        Met Thr Pro Gln Leu Leu Leu Ala Leu Val Leu Trp Ala Ser
         1               5                   10
 
tgc ccg ccc tgc agt gga agg aaa ggg ccc cca gca gct ctg aca ctg   97
Cys Pro Pro Cys Ser Gly Arg Lys Gly Pro Pro Ala Ala Leu Thr Leu
 15                  20                  25                  30
 
ccc cgg gtg caa tgc cga gcc tct cgg tac ccg atc gcc gtg gat tgc   145
Pro Arg Val Gln Cys Arg Ala Ser Arg Tyr Pro Ile Ala Val Asp Cys
                 35                  40                  45
 
tcc tgg acc ctg ccg cct gct cca aac tcc acc agc ccc gtg tcc ttc   193
Ser Trp Thr Leu Pro Pro Ala Pro Asn Ser Thr Ser Pro Val Ser Phe
             50                  55                  60
 
att gcc acg tac agg ctc ggc atg gct gcc cgg ggc cac agc tgg ccc   241
Ile Ala Thr Tyr Arg Leu Gly Met Ala Ala Arg Gly His Ser Trp Pro
         65                  70                  75
 
tgc ctg cag cag acg cca acg tcc acc agc tgc acc atc acg gat gtc   289
Cys Leu Gln Gln Thr Pro Thr Ser Thr Ser Cys Thr Ile Thr Asp Val
     80                  85                  90
 
cag ctg ttc tcc atg gct ccc tac gtg ctc aat gtc acc gcc gtc cac   337
Gln Leu Phe Ser Met Ala Pro Tyr Val Leu Asn Val Thr Ala Val His
 95                 100                 105                 110
 
ccc tgg ggc tcc agc agc agc ttc gtg cct ttc ata aca gag cac atc   385
Pro Trp Gly Ser Ser Ser Ser Phe Val Pro Phe Ile Thr Glu His Ile
                115                 120                 125
 
atc aag ccc gac cct cca gaa ggc gtg cgc cta agc ccc ctc gct gag   433
Ile Lys Pro Asp Pro Pro Glu Gly Val Arg Leu Ser Pro Leu Ala Glu
            130                 135                 140
 
cgc cag cta cag gtg cag tgg gag cct ccc ggg tcc tgg ccc ttc cca   481
Arg Gln Leu Gln Val Gln Trp Glu Pro Pro Gly Ser Trp Pro Phe Pro
        145                 150                 155
 
gag atc ttc tca ctg aag tac tgg atc cgt tac aag cgt cag gga gct   529
Glu Ile Phe Ser Leu Lys Tyr Trp Ile Arg Tyr Lys Arg Gln Gly Ala
    160                 165                 170
 
gcg cgc ttc cac cgg gtg ggg ccc att gaa gcc acg tcc ttc atc ctc   577
Ala Arg Phe His Arg Val Gly Pro Ile Glu Ala Thr Ser Phe Ile Leu
175                 180                 185                 190
 
agg gct gtg cgg ccc cga gcc agg tac tac gtc caa gtg gcg gct cag   625
Arg Ala Val Arg Pro Arg Ala Arg Tyr Tyr Val Gln Val Ala Ala Gln
                195                 200                 205
 
gac ctc aca gac tac ggg gaa ctg agt gac tgg agt ctc ccc gcc act   673
Asp Leu Thr Asp Tyr Gly Glu Leu Ser Asp Trp Ser Leu Pro Ala Thr
            210                 215                 220
 
gcc aca atg agc ctg ggc aag tagcaagggc ttcccgctgc ctccagacag      724
Ala Thr Met Ser Leu Gly Lys
        225
 
cacctgggtc ctcgccaccc taagccccgg gacacctgtt ggagggcgga tgggatctgc 784
ctagcctggg ctggagtcct tgctttgctg ctgctgagct gccgggcaac ctcagatgac 844
cgacttttcc ctttgagcct cagtttctct agctgagaaa tggagatgta ctactctctc 904
ctttaccttt acctttacca cagtgcaggg ctgactgaac tgtcactgtg agatattttt 964
tattgtttaa ttagaaaaga attgttgttg ggctgggcgc agtggatcgc acctgtaatc 1024
ccagtcactg ggaagccgac gtgggagggt agcttgaggc caggagctcg aaaccagtcc 1084
gggccacaca gcaagacccc atctctaaaa aattaatata aatataaaat aaattaaaaa 1144
aaaaaaaaaa aaaaaaaaaa aaaaa                                       1169

<210> 2
<211> 687
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (1)...(687)

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> coding sequence for EBI3 of GenBank Acc. BC0046112

<400> 2
atg acc ccg cag ctt ctc ctg gcc ctt gtc ctc tgg gcc agc tgc ccg   48
Met Thr Pro Gln Leu Leu Leu Ala Leu Val Leu Trp Ala Ser Cys Pro
 1               5                   10                  15
 
ccc tgc agt gga agg aaa ggg ccc cca gca gct ctg aca ctg ccc cgg   96
Pro Cys Ser Gly Arg Lys Gly Pro Pro Ala Ala Leu Thr Leu Pro Arg
             20                  25                  30
 
gtg caa tgc cga gcc tct cgg tac ccg atc gcc gtg gat tgc tcc tgg   144
Val Gln Cys Arg Ala Ser Arg Tyr Pro Ile Ala Val Asp Cys Ser Trp
         35                  40                  45
 
acc ctg ccg cct gct cca aac tcc acc agc ccc gtg tcc ttc att gcc   192
Thr Leu Pro Pro Ala Pro Asn Ser Thr Ser Pro Val Ser Phe Ile Ala
     50                  55                  60
 
acg tac agg ctc ggc atg gct gcc cgg ggc cac agc tgg ccc tgc ctg   240
Thr Tyr Arg Leu Gly Met Ala Ala Arg Gly His Ser Trp Pro Cys Leu
 65                  70                  75                  80
 
cag cag acg cca acg tcc acc agc tgc acc atc acg gat gtc cag ctg   288
Gln Gln Thr Pro Thr Ser Thr Ser Cys Thr Ile Thr Asp Val Gln Leu
                 85                  90                  95
 
ttc tcc atg gct ccc tac gtg ctc aat gtc acc gcc gtc cac ccc tgg   336
Phe Ser Met Ala Pro Tyr Val Leu Asn Val Thr Ala Val His Pro Trp
            100                 105                 110
 
ggc tcc agc agc agc ttc gtg cct ttc ata aca gag cac atc atc aag   384
Gly Ser Ser Ser Ser Phe Val Pro Phe Ile Thr Glu His Ile Ile Lys
        115                 120                 125
 
ccc gac cct cca gaa ggc gtg cgc cta agc ccc ctc gct gag cgc cag   432
Pro Asp Pro Pro Glu Gly Val Arg Leu Ser Pro Leu Ala Glu Arg Gln
    130                 135                 140
 
cta cag gtg cag tgg gag cct ccc ggg tcc tgg ccc ttc cca gag atc   480
Leu Gln Val Gln Trp Glu Pro Pro Gly Ser Trp Pro Phe Pro Glu Ile
145                 150                 155                 160
 
ttc tca ctg aag tac tgg atc cgt tac aag cgt cag gga gct gcg cgc   528
Phe Ser Leu Lys Tyr Trp Ile Arg Tyr Lys Arg Gln Gly Ala Ala Arg
                165                 170                 175
 
ttc cac cgg gtg ggg ccc att gaa gcc acg tcc ttc atc ctc agg gct   576
Phe His Arg Val Gly Pro Ile Glu Ala Thr Ser Phe Ile Leu Arg Ala
            180                 185                 190
 
gtg cgg ccc cga gcc agg tac tac gtc caa gtg gcg gct cag gac ctc   624
Val Arg Pro Arg Ala Arg Tyr Tyr Val Gln Val Ala Ala Gln Asp Leu
        195                 200                 205
 
aca gac tac ggg gaa ctg agt gac tgg agt ctc ccc gcc act gcc aca   672
Thr Asp Tyr Gly Glu Leu Ser Asp Trp Ser Leu Pro Ala Thr Ala Thr
    210                 215                 220
 
atg agc ctg ggc aag                                               687
Met Ser Leu Gly Lys
225
 

<210> 3
<211> 229
<212> PRT
<213> Homo sapiens

<400> 3
Met Thr Pro Gln Leu Leu Leu Ala Leu Val Leu Trp Ala Ser Cys Pro
 1               5                  10                  15      
Pro Cys Ser Gly Arg Lys Gly Pro Pro Ala Ala Leu Thr Leu Pro Arg
            20                  25                  30          
Val Gln Cys Arg Ala Ser Arg Tyr Pro Ile Ala Val Asp Cys Ser Trp
        35                  40                  45              
Thr Leu Pro Pro Ala Pro Asn Ser Thr Ser Pro Val Ser Phe Ile Ala
    50                  55                  60                  
Thr Tyr Arg Leu Gly Met Ala Ala Arg Gly His Ser Trp Pro Cys Leu
65                  70                  75                  80  
Gln Gln Thr Pro Thr Ser Thr Ser Cys Thr Ile Thr Asp Val Gln Leu
                85                  90                  95      
Phe Ser Met Ala Pro Tyr Val Leu Asn Val Thr Ala Val His Pro Trp
            100                 105                 110         
Gly Ser Ser Ser Ser Phe Val Pro Phe Ile Thr Glu His Ile Ile Lys
        115                 120                 125             
Pro Asp Pro Pro Glu Gly Val Arg Leu Ser Pro Leu Ala Glu Arg Gln
    130                 135                 140                 
Leu Gln Val Gln Trp Glu Pro Pro Gly Ser Trp Pro Phe Pro Glu Ile
145                 150                 155                 160 
Phe Ser Leu Lys Tyr Trp Ile Arg Tyr Lys Arg Gln Gly Ala Ala Arg
                165                 170                 175     
Phe His Arg Val Gly Pro Ile Glu Ala Thr Ser Phe Ile Leu Arg Ala
            180                 185                 190         
Val Arg Pro Arg Ala Arg Tyr Tyr Val Gln Val Ala Ala Gln Asp Leu
        195                 200                 205             
Thr Asp Tyr Gly Glu Leu Ser Asp Trp Ser Leu Pro Ala Thr Ala Thr
    210                 215                 220                 
Met Ser Leu Gly Lys
225                 


<210> 4
<211> 762
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (1)...(759)

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> coding seqeuence of P35 from GenBank AAH46112.1

<400> 4
atg tgg ccc cct ggg tca gcc tcc cag cca ccg ccc tca cct gcc gcg   48
Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala
 1               5                   10                  15
 
gcc aca ggt ctg cat cca gcg gct cgc cct gtg tcc ctg cag tgc cgg   96
Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg
             20                  25                  30
 
ctc agc atg tgt cca gcg cgc agc ctc ctc ctt gtg gct acc ctg gtc   144
Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val
         35                  40                  45
 
ctc ctg gac cac ctc agt ttg gcc aga aac ctc ccc gtg gcc act cca   192
Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro
     50                  55                  60
 
gac cca gga atg ttc cca tgc ctt cac cac tcc caa aac ctg ctg agg   240
Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg
 65                  70                  75                  80
 
gcc gtc agc aac atg ctc cag aag gcc aga caa act cta gaa ttt tac   288
Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr
                 85                  90                  95
 
cct tgc act tct gaa gag att gat cat gaa gat atc aca aaa gat aaa   336
Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys
            100                 105                 110
 
acc agc aca gtg gag gcc tgt tta cca ttg gaa tta acc aag aat gag   384
Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu
        115                 120                 125
 
agt tgc cta aat tcc aga gag acc tct ttc ata act aat ggg agt tgc   432
Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys
    130                 135                 140
 
ctg gcc tcc aga aag acc tct ttt atg atg gcc ctg tgc ctt agt agt   480
Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser
145                 150                 155                 160
 
att tat gaa gac ttg aag atg tac cag gtg gag ttc aag acc atg aat   528
Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn
                165                 170                 175
 
gca aag ctt ctg atg gat cct aag agg cag atc ttt cta gat caa aac   576
Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn
            180                 185                 190
 
atg ctg gca gtt att gat gag ctg atg cag gcc ctg aat ttc aac agt   624
Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser
        195                 200                 205
 
gag act gtg cca caa aaa tcc tcc ctt gaa gaa ccg gat ttt tat aaa   672
Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys
    210                 215                 220
 
act aaa atc aag ctc tgc ata ctt ctt cat gct ttc aga att cgg gca   720
Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala
225                 230                 235                 240
 
gtg act att gat aga gtg atg agc tat ctg aat gct tcc taa           762
Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser
                245                 250
 

<210> 5
<211> 253
<212> PRT
<213> Homo sapiens

<400> 5
Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala
 1               5                  10                  15      
Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg
            20                  25                  30          
Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val
        35                  40                  45              
Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro
    50                  55                  60                  
Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg
65                  70                  75                  80  
Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr
                85                  90                  95      
Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys
            100                 105                 110         
Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu
        115                 120                 125             
Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys
    130                 135                 140                 
Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser
145                 150                 155                 160 
Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn
                165                 170                 175     
Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn
            180                 185                 190         
Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser
        195                 200                 205             
Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys
    210                 215                 220                 
Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala
225                 230                 235                 240 
Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser
                245                 250             


<210> 6
<211> 253
<212> PRT
<213> Homo sapiens

<400> 6
Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala
 1               5                  10                  15      
Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg
            20                  25                  30          
Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val
        35                  40                  45              
Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro
    50                  55                  60                  
Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg
65                  70                  75                  80  
Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr
                85                  90                  95      
Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys
            100                 105                 110         
Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu
        115                 120                 125             
Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys
    130                 135                 140                 
Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser
145                 150                 155                 160 
Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn
                165                 170                 175     
Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn
            180                 185                 190         
Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser
        195                 200                 205             
Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys
    210                 215                 220                 
Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala
225                 230                 235                 240 
Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser
                245                 250             

