                         SEQUENCE LISTING

<110>  Vitaliano, Franco
       Vitaliano, Gordana D
 
<120>  DYNAMIC BIO-NANOPARTICLE ELEMENTS



<130>  FV3011

<140>  US 12/399,906
<141>  2009-03-06

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  1675
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProtKB/Q00610
<309>  2009-05-26
<313>  (1)..(1675)

<400>  1

Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Thr Asp Asp Val Thr Phe Trp Lys 
            100                 105                 110         


Trp Ile Ser Leu Asn Thr Val Ala Leu Val Thr Asp Asn Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys Met Phe Asp Arg 
    130                 135                 140                 


His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr Arg Thr Asp Ala 
145                 150                 155                 160 


Lys Gln Lys Trp Leu Leu Leu Thr Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Glu Glu Ser Thr Leu Phe Cys Phe Ala Val Arg Gly Gln Ala 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Thr Pro Pro Thr Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu Lys His Asp Val 
            260                 265                 270         


Val Phe Leu Ile Thr Lys Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Thr Gly Thr Cys Ile Tyr Met Asn Arg Ile Ser Gly Glu Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Glu Ala Thr Ala Gly Ile Ile Gly Val Asn Arg 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu Asn Ile Ile Pro 
                325                 330                 335     


Tyr Ile Thr Asn Val Leu Gln Asn Pro Asp Leu Ala Leu Arg Met Ala 
            340                 345                 350         


Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe 
        355                 360                 365             


Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Asn Ala Pro Lys Gly Ile Leu Arg Thr Pro Asp Thr Ile Arg Arg 
385                 390                 395                 400 


Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Thr Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Ser Val Asp Pro Thr Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile Ser Pro Asp Gln 
        515                 520                 525             


Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asp Ile Thr Gln Ile Val Asp Val Phe Met Glu Tyr Asn Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ala Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser 
                565                 570                 575     


Glu Gly Pro Leu Gln Thr Arg Leu Leu Glu Met Asn Leu Met His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Arg Ala Leu Glu His Phe Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Ser Thr Gln Ser Leu Ile Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Asn 
            740                 745                 750         


Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Asp Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu Pro Val Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val Ile Lys Asn Leu 
            820                 825                 830         


Ile Leu Val Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala 
    850                 855                 860                 


Arg Ile His Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu 
                885                 890                 895     


Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser 
    930                 935                 940                 


Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp Gly Ser Val Leu 
945                 950                 955                 960 


Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Gln Asp Pro Glu Glu Val Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Asn  Arg Leu Asp Asn Tyr  Asp Ala Pro 
    1040                 1045                 1050             


Asp Ile  Ala Asn Ile Ala Ile  Ser Asn Glu Leu Phe  Glu Glu Ala 
    1055                 1060                 1065             


Phe Ala  Ile Phe Arg Lys Phe  Asp Val Asn Thr Ser  Ala Val Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Lys 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Gly Met  Val Lys Glu Ala Ile  Asp Ser Tyr 
    1115                 1120                 1125             


Ile Lys  Ala Asp Asp Pro Ser  Ser Tyr Met Glu Val  Val Gln Ala 
    1130                 1135                 1140             


Ala Asn  Thr Ser Gly Asn Trp  Glu Glu Leu Val Lys  Tyr Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Ala Arg  Glu Ser Tyr Val Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Asn Arg Leu Ala Glu  Leu Glu Glu 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Asp Glu Lys Met  Tyr Asp Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Asn Asn  Val Ser Asn Phe Gly  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Gly Ala Arg  Lys Ala Asn 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Val Asp Gly 
    1250                 1255                 1260             


Lys Glu  Phe Arg Leu Ala Gln  Met Cys Gly Leu His  Ile Val Val 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Ile Asn Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Thr Met Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Arg Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Ile  Ile Thr Met Met Asn  His Pro Thr 
    1370                 1375                 1380             


Asp Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Tyr Tyr  Arg Ala Ile Gln Phe  Tyr Leu Glu 
    1400                 1405                 1410             


Phe Lys  Pro Leu Leu Leu Asn  Asp Leu Leu Met Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Arg Ala  Val Asn Tyr Phe Ser  Lys Val Lys 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Asn His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ser Leu Asn Asn Leu  Phe Ile Thr 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Ala Leu  Arg Thr Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Arg Leu Glu  Lys His Glu 
    1490                 1495                 1500             


Leu Ile  Glu Phe Arg Arg Ile  Ala Ala Tyr Leu Phe  Lys Gly Asn 
    1505                 1510                 1515             


Asn Arg  Trp Lys Gln Ser Val  Glu Leu Cys Lys Lys  Asp Ser Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln Tyr  Ala Ser Glu Ser Lys  Asp Thr Glu 
    1535                 1540                 1545             


Leu Ala  Glu Glu Leu Leu Gln  Trp Phe Leu Gln Glu  Glu Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Gly Ala Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Val Val Leu Glu Thr  Ala Trp Arg His Asn  Ile Met Asp 
    1580                 1585                 1590             


Phe Ala  Met Pro Tyr Phe Ile  Gln Val Met Lys Glu  Tyr Leu Thr 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Ser Glu Ser Leu Arg  Lys Glu Glu 
    1610                 1615                 1620             


Glu Gln  Ala Thr Glu Thr Gln  Pro Ile Val Tyr Gly  Gln Pro Gln 
    1625                 1630                 1635             


Leu Met  Leu Thr Ala Gly Pro  Ser Val Ala Val Pro  Pro Gln Ala 
    1640                 1645                 1650             


Pro Phe  Gly Tyr Gly Tyr Thr  Ala Pro Pro Tyr Gly  Gln Pro Gln 
    1655                 1660                 1665             


Pro Gly  Phe Gly Tyr Ser Met  
    1670                 1675 


<210>  2
<211>  1640
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProtKB/P53675
<309>  2009-05-26
<313>  (1)..(1640)

<400>  2

Met Ala Gln Ile Leu Pro Val Arg Phe Gln Glu His Phe Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Thr Ile Ile Asp Met Ser Asp Pro Met Ala Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Glu Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Ala Glu Glu Val Ile Phe Trp Lys 
            100                 105                 110         


Trp Val Ser Val Asn Thr Val Ala Leu Val Thr Glu Thr Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Asp Ser Gln Pro Met Lys Met Phe Asp Arg 
    130                 135                 140                 


His Thr Ser Leu Val Gly Cys Gln Val Ile His Tyr Arg Thr Asp Glu 
145                 150                 155                 160 


Tyr Gln Lys Trp Leu Leu Leu Val Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ala Phe Ala Glu Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Lys Pro Ala Thr Leu Phe Cys Phe Ala Val Arg Asn Pro Thr 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Gln Pro Ala Ala Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Val Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Gly Ala Lys His Gly Val 
            260                 265                 270         


Ile Tyr Leu Ile Thr Lys Tyr Gly Tyr Leu His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Ser Gly Val Cys Ile Cys Met Asn Arg Ile Ser Ala Asp Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Lys Pro Thr Ser Gly Ile Ile Gly Val Asn Thr 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Asp Asn Ile Val Asn 
                325                 330                 335     


Tyr Ala Thr Asn Val Leu Gln Asn Pro Asp Leu Gly Leu Arg Leu Ala 
            340                 345                 350         


Val Arg Ser Asn Leu Ala Gly Ala Glu Lys Leu Phe Val Arg Lys Phe 
        355                 360                 365             


Asn Thr Leu Phe Ala Gln Gly Ser Tyr Ala Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Ser Ala Pro Lys Gly Ile Leu Arg Thr Arg Glu Thr Val Gln Lys 
385                 390                 395                 400 


Phe Gln Ser Ile Pro Ala Gln Ser Gly Gln Ala Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Leu Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys His Leu Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Thr Thr Asp Pro Met Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Ser Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Phe Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Gly Val Met Lys Ile Ser Pro Glu Gln 
        515                 520                 525             


Gly Leu Gln Phe Ser Arg Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asn Ile Ser Gln Ile Val Asp Ile Phe Met Glu Asn Ser Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ser Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ala 
                565                 570                 575     


Glu Gly Leu Leu Gln Thr Trp Leu Leu Glu Met Asn Leu Val His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Lys Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Gln Ala Leu Glu His Tyr Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Phe Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Val Glu Cys Leu His Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Leu Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Gly Thr Gln Ala Leu Val Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Tyr Lys Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Leu Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Ser 
            740                 745                 750         


Cys Tyr Asn Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Gly Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Arg Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Thr Pro Ala Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Glu Val Ile Lys His Leu 
            820                 825                 830         


Ile Met Ala Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ser 
    850                 855                 860                 


Gln Ile Gln Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Ser Pro Glu Cys Phe Leu Arg Glu 
                885                 890                 895     


Asn Ala Tyr Tyr Asp Ser Ser Val Val Gly Arg Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Lys Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Glu Ala 
    930                 935                 940                 


Arg Tyr Leu Val Cys Arg Lys Asp Pro Glu Leu Trp Ala His Val Leu 
945                 950                 955                 960 


Glu Glu Thr Asn Pro Ser Arg Arg Gln Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Arg Asp Pro Glu Glu Ile Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Ser  Arg Leu Asp Asn Tyr  Asp Ala Leu 
    1040                 1045                 1050             


Asp Ile  Ala Ser Ile Ala Val  Ser Ser Ala Leu Tyr  Glu Glu Ala 
    1055                 1060                 1065             


Phe Thr  Val Phe His Lys Phe  Asp Met Asn Ala Ser  Ala Ile Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Gln 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Asp Leu  Val Lys Glu Ala Ile  Asn Ser Tyr 
    1115                 1120                 1125             


Ile Arg  Gly Asp Asp Pro Ser  Ser Tyr Leu Glu Val  Val Gln Ser 
    1130                 1135                 1140             


Ala Ser  Arg Ser Asn Asn Trp  Glu Asp Leu Val Lys  Phe Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Gly Arg  Glu Ser Tyr Ile Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Ser Arg Val Ser Glu  Leu Glu Asp 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Glu Glu Gly Met  Tyr Glu Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Ser Asn  Val Ser Asn Phe Ala  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Asn Ser Arg  Lys Ala Ser 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Met Asp Gly 
    1250                 1255                 1260             


Gln Glu  Phe Arg Phe Ala Gln  Leu Cys Gly Leu His  Ile Val Ile 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Met Cys Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Leu Leu Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Leu Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Val  Leu Thr Met Met Ser  His Pro Thr 
    1370                 1375                 1380             


Glu Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Cys Tyr  Arg Ala Leu Gln Phe  Tyr Leu Asp 
    1400                 1405                 1410             


Tyr Lys  Pro Leu Leu Ile Asn  Asp Leu Leu Leu Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Trp Thr  Val Ser Phe Phe Ser  Lys Ala Gly 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Ser His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ala Leu Asn His Leu  Leu Thr Glu 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Gly Leu  Arg Ala Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Gln Leu Glu  Lys His Gln 
    1490                 1495                 1500             


Leu Met  Glu Phe Arg Cys Ile  Ala Ala Tyr Leu Tyr  Lys Gly Asn 
    1505                 1510                 1515             


Asn Trp  Trp Ala Gln Ser Val  Glu Leu Cys Lys Lys  Asp His Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln His  Ala Ala Glu Ser Arg  Asp Ala Glu 
    1535                 1540                 1545             


Leu Ala  Gln Lys Leu Leu Gln  Trp Phe Leu Glu Glu  Gly Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Ala Ala Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Met Val Leu Glu Leu  Ala Trp Arg His Asn  Leu Val Asp 
    1580                 1585                 1590             


Leu Ala  Met Pro Tyr Phe Ile  Gln Val Met Arg Glu  Tyr Leu Ser 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Leu Glu Ser Leu Arg  Lys Gln Glu 
    1610                 1615                 1620             


Glu His  Val Thr Glu Pro Ala  Pro Leu Val Phe Asp  Phe Asp Gly 
    1625                 1630                 1635             


His Glu  
    1640 


<210>  3
<211>  1583
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/EAX03047
<309>  2006-12-18
<313>  (1)..(1583)

<400>  3

Met Ala Gln Ile Leu Pro Val Arg Phe Gln Glu His Phe Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Thr Ile Ile Asp Met Ser Asp Pro Met Ala Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Glu Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Ala Glu Glu Val Ile Phe Trp Lys 
            100                 105                 110         


Trp Val Ser Val Asn Thr Val Ala Leu Val Thr Glu Thr Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Asp Ser Gln Pro Met Lys Met Phe Asp Arg 
    130                 135                 140                 


His Thr Ser Leu Val Gly Cys Gln Val Ile His Tyr Arg Thr Asp Glu 
145                 150                 155                 160 


Tyr Gln Lys Trp Leu Leu Leu Val Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ala Phe Ala Glu Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Lys Pro Ala Thr Leu Phe Cys Phe Ala Val Arg Asn Pro Thr 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Gln Pro Ala Ala Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Val Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Gly Ala Lys His Gly Val 
            260                 265                 270         


Ile Tyr Leu Ile Thr Lys Tyr Gly Tyr Leu His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Ser Gly Val Cys Ile Cys Met Asn Arg Ile Ser Ala Asp Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Lys Pro Thr Ser Gly Ile Ile Gly Val Asn Lys 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Asp Asn Ile Val Asn 
                325                 330                 335     


Tyr Ala Thr Asn Val Leu Gln Asn Pro Asp Leu Gly Leu Arg Leu Ala 
            340                 345                 350         


Val Arg Ser Asn Leu Ala Gly Ala Glu Lys Leu Phe Val Arg Lys Phe 
        355                 360                 365             


Asn Thr Leu Phe Ala Gln Gly Ser Tyr Ala Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Ser Ala Pro Lys Gly Ile Leu Arg Thr Arg Glu Thr Val Gln Lys 
385                 390                 395                 400 


Phe Gln Ser Ile Pro Ala Gln Ser Gly Gln Ala Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Leu Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys His Leu Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Thr Thr Asp Pro Met Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Ser Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Phe Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Gly Val Met Lys Ile Ser Pro Glu Gln 
        515                 520                 525             


Gly Leu Gln Phe Ser Arg Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asn Ile Ser Gln Ile Val Asp Ile Phe Met Glu Asn Ser Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ser Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ala 
                565                 570                 575     


Glu Gly Leu Leu Gln Thr Trp Leu Leu Glu Met Asn Leu Val His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Lys Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Gln Ala Leu Glu His Tyr Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Phe Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Val Glu Cys Leu His Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Leu Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Gly Thr Gln Ala Leu Val Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Tyr Lys Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Leu Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Ser 
            740                 745                 750         


Cys Tyr Asn Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Gly Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Arg Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Thr Pro Ala Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Glu Val Ile Lys His Leu 
            820                 825                 830         


Ile Met Ala Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ser 
    850                 855                 860                 


Gln Ile Gln Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Ser Pro Glu Cys Phe Leu Arg Glu 
                885                 890                 895     


Asn Ala Tyr Tyr Asp Ser Ser Val Val Gly Arg Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Lys Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Glu Ala 
    930                 935                 940                 


Arg Tyr Leu Val Cys Arg Lys Asp Pro Glu Leu Trp Ala His Val Leu 
945                 950                 955                 960 


Glu Glu Thr Asn Pro Ser Arg Arg Gln Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Arg Asp Pro Glu Glu Ile Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Ser  Arg Leu Asp Asn Tyr  Asp Ala Leu 
    1040                 1045                 1050             


Asp Ile  Ala Ser Ile Ala Val  Ser Ser Ala Leu Tyr  Glu Glu Ala 
    1055                 1060                 1065             


Phe Thr  Val Phe His Lys Phe  Asp Met Asn Ala Ser  Ala Ile Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Gln 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Asp Leu  Val Lys Glu Ala Ile  Asn Ser Tyr 
    1115                 1120                 1125             


Ile Arg  Gly Asp Asp Pro Ser  Ser Tyr Leu Glu Val  Val Gln Ser 
    1130                 1135                 1140             


Ala Ser  Arg Ser Asn Asn Trp  Glu Asp Leu Val Lys  Phe Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Gly Arg  Glu Ser Tyr Ile Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Ser Arg Val Ser Glu  Leu Glu Asp 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Glu Glu Gly Met  Tyr Glu Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Ser Asn  Val Ser Asn Phe Ala  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Asn Ser Arg  Lys Ala Ser 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Met Asp Gly 
    1250                 1255                 1260             


Gln Glu  Phe Arg Phe Ala Gln  Leu Cys Gly Leu His  Ile Val Ile 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Met Cys Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Leu Leu Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Leu Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Val  Leu Thr Met Met Ser  His Pro Thr 
    1370                 1375                 1380             


Glu Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Cys Tyr  Arg Ala Leu Gln Phe  Tyr Leu Asp 
    1400                 1405                 1410             


Tyr Lys  Pro Leu Leu Ile Asn  Asp Leu Leu Leu Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Trp Thr  Val Ser Phe Phe Ser  Lys Ala Gly 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Ser His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ala Leu Asn His Leu  Leu Thr Glu 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Asp Ala  Met Gln His Ala Ala  Glu Ser Arg 
    1475                 1480                 1485             


Asp Ala  Glu Leu Ala Gln Lys  Leu Leu Gln Trp Phe  Leu Glu Glu 
    1490                 1495                 1500             


Gly Lys  Arg Glu Cys Phe Ala  Ala Cys Leu Phe Thr  Cys Tyr Asp 
    1505                 1510                 1515             


Leu Leu  Arg Pro Asp Met Val  Leu Glu Leu Ala Trp  Arg His Asn 
    1520                 1525                 1530             


Leu Val  Asp Leu Ala Met Pro  Tyr Phe Ile Gln Val  Met Arg Glu 
    1535                 1540                 1545             


Tyr Leu  Ser Lys Val Asp Lys  Leu Asp Ala Leu Glu  Ser Leu Arg 
    1550                 1555                 1560             


Lys Gln  Glu Glu His Val Thr  Glu Pro Ala Pro Leu  Val Phe Asp 
    1565                 1570                 1575             


Phe Asp  Gly His Glu 
    1580             


<210>  4
<211>  1685
<212>  PRT
<213>  Homo sapiens

<300>
<308>   NCBI/BAA04801
<309>  2004-01-10
<313>  (1)..(1685)

<400>  4

Gln Glu Glu Thr Ile Thr Pro Asp Ser Ala Met Ala Gln Ile Leu Pro 
1               5                   10                  15      


Ile Arg Phe Gln Glu His Leu Gln Leu Gln Asn Leu Gly Ile Asn Pro 
            20                  25                  30          


Ala Asn Ile Gly Phe Ser Thr Leu Thr Met Glu Ser Asp Lys Phe Ile 
        35                  40                  45              


Cys Ile Arg Glu Lys Val Gly Glu Gln Ala Gln Val Val Ile Ile Asp 
    50                  55                  60                  


Met Asn Asp Pro Ser Asn Pro Ile Arg Arg Pro Ile Ser Ala Asp Ser 
65                  70                  75                  80  


Ala Ile Met Asn Pro Ala Ser Lys Val Ile Ala Leu Lys Ala Gly Lys 
                85                  90                  95      


Thr Leu Gln Ile Phe Asn Ile Glu Met Lys Ser Lys Met Lys Ala His 
            100                 105                 110         


Thr Met Thr Asp Asp Val Thr Phe Trp Lys Trp Ile Ser Leu Asn Thr 
        115                 120                 125             


Val Ala Leu Val Thr Asp Asn Ala Val Tyr His Trp Ser Met Glu Gly 
    130                 135                 140                 


Glu Ser Gln Pro Val Lys Met Phe Asp Arg His Ser Ser Leu Ala Gly 
145                 150                 155                 160 


Cys Gln Ile Ile Asn Tyr Arg Thr Asp Ala Lys Gln Lys Trp Leu Leu 
                165                 170                 175     


Leu Thr Gly Ile Ser Ala Gln Gln Asn Arg Val Val Gly Ala Met Gln 
            180                 185                 190         


Leu Tyr Ser Val Asp Arg Lys Val Ser Gln Pro Ile Glu Gly His Ala 
        195                 200                 205             


Ala Ser Phe Ala Gln Phe Lys Met Glu Gly Asn Ala Glu Glu Ser Thr 
    210                 215                 220                 


Leu Phe Cys Phe Ala Val Arg Gly Gln Ala Gly Gly Lys Leu His Ile 
225                 230                 235                 240 


Ile Glu Val Gly Thr Pro Pro Thr Gly Asn Gln Pro Phe Pro Lys Lys 
                245                 250                 255     


Ala Val Asp Val Phe Phe Pro Pro Glu Ala Gln Asn Asp Phe Pro Val 
            260                 265                 270         


Ala Met Gln Ile Ser Glu Lys His Asp Val Val Phe Leu Ile Thr Lys 
        275                 280                 285             


Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu Thr Gly Thr Cys Ile Tyr 
    290                 295                 300                 


Met Asn Arg Ile Ser Gly Glu Thr Ile Phe Val Thr Ala Pro His Glu 
305                 310                 315                 320 


Ala Thr Ala Gly Ile Ile Gly Val Asn Arg Lys Gly Gln Val Leu Ser 
                325                 330                 335     


Val Cys Val Glu Glu Glu Asn Ile Ile Pro Tyr Ile Thr Asn Val Leu 
            340                 345                 350         


Gln Asn Pro Asp Leu Ala Leu Arg Met Ala Val Arg Asn Asn Leu Ala 
        355                 360                 365             


Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe Asn Ala Leu Phe Ala Gln 
    370                 375                 380                 


Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala Ala Asn Ala Pro Lys Gly 
385                 390                 395                 400 


Ile Leu Arg Thr Pro Asp Thr Ile Arg Arg Phe Gln Ser Val Pro Ala 
                405                 410                 415     


Gln Pro Gly Gln Thr Ser Pro Leu Leu Gln Tyr Phe Gly Ile Leu Leu 
            420                 425                 430         


Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser Leu Glu Leu Cys Arg Pro 
        435                 440                 445             


Val Leu Gln Gln Gly Arg Lys Gln Leu Leu Glu Lys Trp Leu Lys Glu 
    450                 455                 460                 


Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly Asp Leu Val Lys Ser Val 
465                 470                 475                 480 


Asp Pro Thr Leu Ala Leu Ser Val Tyr Leu Arg Ala Asn Val Pro Asn 
                485                 490                 495     


Lys Val Ile Gln Cys Phe Ala Glu Thr Gly Gln Val Gln Lys Ile Val 
            500                 505                 510         


Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro Asp Trp Ile Phe Leu Leu 
        515                 520                 525             


Arg Asn Val Met Arg Ile Ser Pro Asp Gln Gly Gln Gln Phe Ala Gln 
    530                 535                 540                 


Met Leu Val Gln Asp Glu Glu Pro Leu Ala Asp Ile Thr Gln Ile Val 
545                 550                 555                 560 


Asp Val Phe Met Glu Tyr Asn Leu Ile Gln Gln Cys Thr Ala Phe Leu 
                565                 570                 575     


Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser Glu Gly Pro Leu Gln Thr 
            580                 585                 590         


Arg Leu Leu Glu Met Asn Leu Met His Ala Pro Gln Val Ala Asp Ala 
        595                 600                 605             


Ile Leu Gly Asn Gln Met Phe Thr His Tyr Asp Arg Ala His Ile Ala 
    610                 615                 620                 


Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln Arg Ala Leu Glu His Phe 
625                 630                 635                 640 


Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val Val His Thr His Leu Leu 
                645                 650                 655     


Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly Ser Leu Ser Val Glu Asp 
            660                 665                 670         


Ser Leu Glu Cys Leu Arg Ala Met Leu Ser Ala Asn Ile Arg Gln Asn 
        675                 680                 685             


Leu Gln Ile Cys Val Gln Val Ala Ser Lys Tyr His Glu Gln Leu Ser 
    690                 695                 700                 


Thr Gln Ser Leu Ile Glu Leu Phe Glu Ser Phe Lys Ser Phe Glu Gly 
705                 710                 715                 720 


Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn Phe Ser Gln Asp Pro Asp 
                725                 730                 735     


Val His Phe Lys Tyr Ile Gln Ala Ala Cys Lys Thr Gly Gln Ile Lys 
            740                 745                 750         


Glu Val Glu Arg Ile Cys Arg Glu Ser Asn Cys Tyr Asp Pro Glu Arg 
        755                 760                 765             


Val Lys Asn Phe Leu Lys Glu Ala Lys Leu Thr Asp Gln Leu Pro Leu 
    770                 775                 780                 


Ile Ile Val Cys Asp Arg Phe Asp Phe Val His Asp Leu Val Leu Tyr 
785                 790                 795                 800 


Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile Glu Ile Tyr Val Gln Lys 
                805                 810                 815     


Val Asn Pro Ser Arg Leu Pro Val Val Ile Gly Gly Leu Leu Asp Val 
            820                 825                 830         


Asp Cys Ser Glu Asp Val Ile Lys Asn Leu Ile Leu Val Val Arg Gly 
        835                 840                 845             


Gln Phe Ser Thr Asp Glu Leu Val Ala Glu Val Glu Lys Arg Asn Arg 
    850                 855                 860                 


Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala Arg Ile His Glu Gly Cys 
865                 870                 875                 880 


Glu Glu Pro Ala Thr His Asn Ala Leu Ala Lys Ile Tyr Ile Asp Ser 
                885                 890                 895     


Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu Asn Pro Tyr Tyr Asp Ser 
            900                 905                 910         


Arg Val Val Gly Lys Tyr Cys Glu Lys Arg Asp Pro His Leu Ala Cys 
        915                 920                 925             


Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu Glu Leu Ile Asn Val Cys 
    930                 935                 940                 


Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser Arg Tyr Leu Val Arg Arg 
945                 950                 955                 960 


Lys Asp Pro Glu Leu Trp Gly Ser Val Leu Leu Glu Ser Asn Pro Tyr 
                965                 970                 975     


Arg Arg Pro Leu Ile Asp Gln Val Val Gln Thr Ala Leu Ser Glu Thr 
            980                 985                 990         


Gln Asp Pro Glu Glu Val Ser Val  Thr Val Lys Ala Phe  Met Thr Ala 
        995                 1000                 1005             


Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu Glu Lys  Ile Val Leu 
    1010                 1015                 1020             


Asp Asn  Ser Val Phe Ser Glu  His Arg Asn Leu Gln  Asn Leu Leu 
    1025                 1030                 1035             


Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr Arg Val  Met Glu Tyr 
    1040                 1045                 1050             


Ile Asn  Arg Leu Asp Asn Tyr  Asp Ala Pro Asp Ile  Ala Asn Ile 
    1055                 1060                 1065             


Ala Ile  Ser Asn Glu Leu Phe  Glu Glu Ala Phe Ala  Ile Phe Arg 
    1070                 1075                 1080             


Lys Phe  Asp Val Asn Thr Ser  Ala Val Gln Val Leu  Ile Glu His 
    1085                 1090                 1095             


Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe Ala Glu  Arg Cys Asn 
    1100                 1105                 1110             


Glu Pro  Ala Val Trp Ser Gln  Leu Ala Lys Ala Gln  Leu Gln Lys 
    1115                 1120                 1125             


Gly Met  Val Lys Glu Ala Ile  Asp Ser Tyr Ile Lys  Ala Asp Asp 
    1130                 1135                 1140             


Pro Ser  Ser Tyr Met Glu Val  Val Gln Ala Ala Asn  Thr Ser Gly 
    1145                 1150                 1155             


Asn Trp  Glu Glu Leu Val Lys  Tyr Leu Gln Met Ala  Arg Lys Lys 
    1160                 1165                 1170             


Ala Arg  Glu Ser Tyr Val Glu  Thr Glu Leu Ile Phe  Ala Leu Ala 
    1175                 1180                 1185             


Lys Thr  Asn Arg Leu Ala Glu  Leu Glu Glu Phe Ile  Asn Gly Pro 
    1190                 1195                 1200             


Asn Asn  Ala His Ile Gln Gln  Val Gly Asp Arg Cys  Tyr Asp Glu 
    1205                 1210                 1215             


Lys Met  Tyr Asp Ala Ala Lys  Leu Leu Tyr Asn Asn  Val Ser Asn 
    1220                 1225                 1230             


Phe Gly  Arg Leu Ala Ser Thr  Leu Val His Leu Gly  Glu Tyr Gln 
    1235                 1240                 1245             


Ala Ala  Val Asp Gly Ala Arg  Lys Ala Asn Ser Thr  Arg Thr Trp 
    1250                 1255                 1260             


Lys Glu  Val Cys Phe Ala Cys  Val Asp Gly Lys Glu  Phe Arg Leu 
    1265                 1270                 1275             


Ala Gln  Met Cys Gly Leu His  Ile Val Val His Ala  Asp Glu Leu 
    1280                 1285                 1290             


Glu Glu  Leu Ile Asn Tyr Tyr  Gln Asp Arg Gly Tyr  Phe Glu Glu 
    1295                 1300                 1305             


Leu Ile  Thr Met Leu Glu Ala  Ala Leu Gly Leu Glu  Arg Ala His 
    1310                 1315                 1320             


Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu Tyr Ser  Lys Phe Lys 
    1325                 1330                 1335             


Pro Gln  Lys Met Arg Glu His  Leu Glu Leu Phe Trp  Ser Arg Val 
    1340                 1345                 1350             


Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu Gln Ala  His Leu Trp 
    1355                 1360                 1365             


Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr Glu Glu  Tyr Asp Asn 
    1370                 1375                 1380             


Ala Ile  Ile Thr Met Met Asn  His Pro Thr Asp Ala  Trp Lys Glu 
    1385                 1390                 1395             


Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val Ala Asn  Val Glu Leu 
    1400                 1405                 1410             


Tyr Tyr  Arg Ala Ile Gln Phe  Tyr Leu Glu Phe Lys  Pro Leu Leu 
    1415                 1420                 1425             


Leu Asn  Asp Leu Leu Met Val  Leu Ser Pro Arg Leu  Asp His Thr 
    1430                 1435                 1440             


Arg Ala  Val Asn Tyr Phe Ser  Lys Val Lys Gln Leu  Pro Leu Val 
    1445                 1450                 1455             


Lys Pro  Tyr Leu Arg Ser Val  Gln Asn His Asn Asn  Lys Ser Val 
    1460                 1465                 1470             


Asn Glu  Ser Leu Asn Asn Leu  Phe Ile Thr Glu Glu  Asp Tyr Gln 
    1475                 1480                 1485             


Ala Leu  Arg Thr Ser Ile Asp  Ala Tyr Asp Asn Phe  Asp Asn Ile 
    1490                 1495                 1500             


Ser Leu  Ala Gln Arg Leu Glu  Lys His Glu Leu Ile  Glu Phe Arg 
    1505                 1510                 1515             


Arg Ile  Ala Ala Tyr Leu Phe  Lys Gly Asn Asn Arg  Trp Lys Gln 
    1520                 1525                 1530             


Ser Val  Glu Leu Cys Lys Lys  Asp Ser Leu Tyr Lys  Asp Ala Met 
    1535                 1540                 1545             


Gln Tyr  Ala Ser Glu Ser Lys  Asp Thr Glu Leu Ala  Glu Glu Leu 
    1550                 1555                 1560             


Leu Gln  Trp Phe Leu Gln Glu  Glu Lys Arg Glu Cys  Phe Gly Ala 
    1565                 1570                 1575             


Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg Pro Asp  Val Val Leu 
    1580                 1585                 1590             


Glu Thr  Ala Trp Arg His Asn  Ile Met Asp Phe Ala  Met Pro Tyr 
    1595                 1600                 1605             


Phe Ile  Gln Val Met Lys Glu  Tyr Leu Thr Lys Val  Asp Lys Leu 
    1610                 1615                 1620             


Asp Ala  Ser Glu Ser Leu Arg  Lys Glu Glu Glu Gln  Ala Thr Glu 
    1625                 1630                 1635             


Thr Gln  Pro Ile Val Tyr Gly  Gln Pro Gln Leu Met  Leu Thr Ala 
    1640                 1645                 1650             


Gly Pro  Ser Val Ala Val Pro  Pro Gln Ala Pro Phe  Gly Tyr Gly 
    1655                 1660                 1665             


Tyr Thr  Ala Pro Pro Tyr Gly  Gln Pro Gln Pro Gly  Phe Gly Tyr 
    1670                 1675                 1680             


Ser Met  
    1685 


<210>  5
<211>  1682
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/EAW94395
<309>  2006-12-18
<313>  (1)..(1682)

<400>  5

Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Thr Asp Asp Val Thr Phe Trp Lys 
            100                 105                 110         


Trp Ile Ser Leu Asn Thr Val Ala Leu Val Thr Asp Asn Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys Met Phe Asp Arg 
    130                 135                 140                 


His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr Arg Thr Asp Ala 
145                 150                 155                 160 


Lys Gln Lys Trp Leu Leu Leu Thr Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Glu Glu Ser Thr Leu Phe Cys Phe Ala Val Arg Gly Gln Ala 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Thr Pro Pro Thr Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu Lys His Asp Val 
            260                 265                 270         


Val Phe Leu Ile Thr Lys Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Thr Gly Thr Cys Ile Tyr Met Asn Arg Ile Ser Gly Glu Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Glu Ala Thr Ala Gly Ile Ile Gly Val Asn Arg 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu Asn Ile Ile Pro 
                325                 330                 335     


Tyr Ile Thr Asn Val Leu Gln Asn Pro Asp Leu Ala Leu Arg Met Ala 
            340                 345                 350         


Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe 
        355                 360                 365             


Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Asn Ala Pro Lys Gly Ile Leu Arg Thr Pro Asp Thr Ile Arg Arg 
385                 390                 395                 400 


Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Thr Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Ser Val Asp Pro Thr Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile Ser Pro Asp Gln 
        515                 520                 525             


Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asp Ile Thr Gln Ile Val Asp Val Phe Met Glu Tyr Asn Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ala Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser 
                565                 570                 575     


Glu Gly Pro Leu Gln Thr Arg Leu Leu Glu Met Asn Leu Met His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Arg Ala Leu Glu His Phe Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Ser Thr Gln Ser Leu Ile Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Asn 
            740                 745                 750         


Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Asp Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu Pro Val Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val Ile Lys Asn Leu 
            820                 825                 830         


Ile Leu Val Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala 
    850                 855                 860                 


Arg Ile His Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu 
                885                 890                 895     


Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser 
    930                 935                 940                 


Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp Gly Ser Val Leu 
945                 950                 955                 960 


Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Gln Asp Pro Glu Glu Val Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Asn  Arg Leu Asp Asn Tyr  Asp Ala Pro 
    1040                 1045                 1050             


Asp Ile  Ala Asn Ile Ala Ile  Ser Asn Glu Leu Phe  Glu Glu Ala 
    1055                 1060                 1065             


Phe Ala  Ile Phe Arg Lys Phe  Asp Val Asn Thr Ser  Ala Val Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Lys 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Gly Met  Val Lys Glu Ala Ile  Asp Ser Tyr 
    1115                 1120                 1125             


Ile Lys  Ala Asp Asp Pro Ser  Ser Tyr Met Glu Val  Val Gln Ala 
    1130                 1135                 1140             


Ala Asn  Thr Ser Gly Asn Trp  Glu Glu Leu Val Lys  Tyr Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Ala Arg  Glu Ser Tyr Val Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Asn Arg Leu Ala Glu  Leu Glu Glu 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Asp Glu Lys Met  Tyr Asp Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Asn Asn  Val Ser Asn Phe Gly  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Gly Ala Arg  Lys Ala Asn 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Val Asp Gly 
    1250                 1255                 1260             


Lys Glu  Phe Arg Leu Ala Gln  Met Cys Gly Leu His  Ile Val Val 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Ile Asn Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Thr Met Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Arg Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Ile  Ile Thr Met Met Asn  His Pro Thr 
    1370                 1375                 1380             


Asp Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Tyr Tyr  Arg Ala Ile Gln Phe  Tyr Leu Glu 
    1400                 1405                 1410             


Phe Lys  Pro Leu Leu Leu Asn  Asp Leu Leu Met Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Arg Ala  Val Asn Tyr Phe Ser  Lys Val Lys 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Asn His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ser Leu Asn Asn Leu  Phe Ile Thr 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Ala Leu  Arg Thr Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Arg Leu Glu  Lys His Glu 
    1490                 1495                 1500             


Leu Ile  Glu Phe Arg Arg Ile  Ala Ala Tyr Leu Phe  Lys Gly Asn 
    1505                 1510                 1515             


Asn Arg  Trp Lys Gln Ser Val  Glu Leu Cys Lys Lys  Asp Ser Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln Tyr  Ala Ser Glu Ser Lys  Asp Thr Glu 
    1535                 1540                 1545             


Leu Ala  Glu Glu Leu Leu Gln  Trp Phe Leu Gln Glu  Glu Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Gly Ala Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Val Val Leu Glu Thr  Ala Trp Arg His Asn  Ile Met Asp 
    1580                 1585                 1590             


Phe Ala  Met Pro Tyr Phe Ile  Gln Val Met Lys Glu  Tyr Leu Thr 
    1595                 1600                 1605             


Lys Val  Asp Ala Ile Lys Glu  Lys Val Asp Lys Leu  Asp Ala Ser 
    1610                 1615                 1620             


Glu Ser  Leu Arg Lys Glu Glu  Glu Gln Ala Thr Glu  Thr Gln Pro 
    1625                 1630                 1635             


Ile Val  Tyr Gly Gln Pro Gln  Leu Met Leu Thr Ala  Gly Pro Ser 
    1640                 1645                 1650             


Val Ala  Val Pro Pro Gln Ala  Pro Phe Gly Tyr Gly  Tyr Thr Ala 
    1655                 1660                 1665             


Pro Pro  Tyr Gly Gln Pro Gln  Pro Gly Phe Gly Tyr  Ser Met 
    1670                 1675                 1680         


<210>  6
<211>  1675
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/EAW94399
<309>  2006-12-18
<313>  (1)..(1675)

<400>  6

Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Thr Asp Asp Val Thr Phe Trp Lys 
            100                 105                 110         


Trp Ile Ser Leu Asn Thr Val Ala Leu Val Thr Asp Asn Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys Met Phe Asp Arg 
    130                 135                 140                 


His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr Arg Thr Asp Ala 
145                 150                 155                 160 


Lys Gln Lys Trp Leu Leu Leu Thr Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Glu Glu Ser Thr Leu Phe Cys Phe Ala Val Arg Gly Gln Ala 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Thr Pro Pro Thr Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu Lys His Asp Val 
            260                 265                 270         


Val Phe Leu Ile Thr Lys Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Thr Gly Thr Cys Ile Tyr Met Asn Arg Ile Ser Gly Glu Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Glu Ala Thr Ala Gly Ile Ile Gly Val Asn Arg 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu Asn Ile Ile Pro 
                325                 330                 335     


Tyr Ile Thr Asn Val Leu Gln Asn Pro Asp Leu Ala Leu Arg Met Ala 
            340                 345                 350         


Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe 
        355                 360                 365             


Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Asn Ala Pro Lys Gly Ile Leu Arg Thr Pro Asp Thr Ile Arg Arg 
385                 390                 395                 400 


Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Thr Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Ser Val Asp Pro Thr Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile Ser Pro Asp Gln 
        515                 520                 525             


Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asp Ile Thr Gln Ile Val Asp Val Phe Met Glu Tyr Asn Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ala Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser 
                565                 570                 575     


Glu Gly Pro Leu Gln Thr Arg Leu Leu Glu Met Asn Leu Met His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Arg Ala Leu Glu His Phe Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Ser Thr Gln Ser Leu Ile Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Asn 
            740                 745                 750         


Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Asp Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu Pro Val Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val Ile Lys Asn Leu 
            820                 825                 830         


Ile Leu Val Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala 
    850                 855                 860                 


Arg Ile His Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu 
                885                 890                 895     


Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser 
    930                 935                 940                 


Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp Gly Ser Val Leu 
945                 950                 955                 960 


Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Gln Asp Pro Glu Glu Val Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Asn  Arg Leu Asp Asn Tyr  Asp Ala Pro 
    1040                 1045                 1050             


Asp Ile  Ala Asn Ile Ala Ile  Ser Asn Glu Leu Phe  Glu Glu Ala 
    1055                 1060                 1065             


Phe Ala  Ile Phe Arg Lys Phe  Asp Val Asn Thr Ser  Ala Val Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Lys 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Gly Met  Val Lys Glu Ala Ile  Asp Ser Tyr 
    1115                 1120                 1125             


Ile Lys  Ala Asp Asp Pro Ser  Ser Tyr Met Glu Val  Val Gln Ala 
    1130                 1135                 1140             


Ala Asn  Thr Ser Gly Asn Trp  Glu Glu Leu Val Lys  Tyr Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Ala Arg  Glu Ser Tyr Val Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Asn Arg Leu Ala Glu  Leu Glu Glu 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Asp Glu Lys Met  Tyr Asp Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Asn Asn  Val Ser Asn Phe Gly  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Gly Ala Arg  Lys Ala Asn 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Val Asp Gly 
    1250                 1255                 1260             


Lys Glu  Phe Arg Leu Ala Gln  Met Cys Gly Leu His  Ile Val Val 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Ile Asn Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Thr Met Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Arg Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Ile  Ile Thr Met Met Asn  His Pro Thr 
    1370                 1375                 1380             


Asp Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Tyr Tyr  Arg Ala Ile Gln Phe  Tyr Leu Glu 
    1400                 1405                 1410             


Phe Lys  Pro Leu Leu Leu Asn  Asp Leu Leu Met Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Arg Ala  Val Asn Tyr Phe Ser  Lys Val Lys 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Asn His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ser Leu Asn Asn Leu  Phe Ile Thr 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Ala Leu  Arg Thr Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Arg Leu Glu  Lys His Glu 
    1490                 1495                 1500             


Leu Ile  Glu Phe Arg Arg Ile  Ala Ala Tyr Leu Phe  Lys Gly Asn 
    1505                 1510                 1515             


Asn Arg  Trp Lys Gln Ser Val  Glu Leu Cys Lys Lys  Asp Ser Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln Tyr  Ala Ser Glu Ser Lys  Asp Thr Glu 
    1535                 1540                 1545             


Leu Ala  Glu Glu Leu Leu Gln  Trp Phe Leu Gln Glu  Glu Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Gly Ala Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Val Val Leu Glu Thr  Ala Trp Arg His Asn  Ile Met Asp 
    1580                 1585                 1590             


Phe Ala  Met Pro Tyr Phe Ile  Gln Val Met Lys Glu  Tyr Leu Thr 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Ser Glu Ser Leu Arg  Lys Glu Glu 
    1610                 1615                 1620             


Glu Gln  Ala Thr Glu Thr Gln  Pro Ile Val Tyr Gly  Gln Pro Gln 
    1625                 1630                 1635             


Leu Met  Leu Thr Ala Gly Pro  Ser Val Ala Val Pro  Pro Gln Ala 
    1640                 1645                 1650             


Pro Phe  Gly Tyr Gly Tyr Thr  Ala Pro Pro Tyr Gly  Gln Pro Gln 
    1655                 1660                 1665             


Pro Gly  Phe Gly Tyr Ser Met  
    1670                 1675 


<210>  7
<211>  1679
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/EAW94397
<309>  2006-12-18
<313>  (1)..(1679)

<400>  7

Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Gly Ile Lys Glu Ser Gly Lys Thr Leu Gln Ile Phe Asn 
                85                  90                  95      


Ile Glu Met Lys Ser Lys Met Lys Ala His Thr Met Thr Asp Asp Val 
            100                 105                 110         


Thr Phe Trp Lys Trp Ile Ser Leu Asn Thr Val Ala Leu Val Thr Asp 
        115                 120                 125             


Asn Ala Val Tyr His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys 
    130                 135                 140                 


Met Phe Asp Arg His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr 
145                 150                 155                 160 


Arg Thr Asp Ala Lys Gln Lys Trp Leu Leu Leu Thr Gly Ile Ser Ala 
                165                 170                 175     


Gln Gln Asn Arg Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg 
            180                 185                 190         


Lys Val Ser Gln Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe 
        195                 200                 205             


Lys Met Glu Gly Asn Ala Glu Glu Ser Thr Leu Phe Cys Phe Ala Val 
    210                 215                 220                 


Arg Gly Gln Ala Gly Gly Lys Leu His Ile Ile Glu Val Gly Thr Pro 
225                 230                 235                 240 


Pro Thr Gly Asn Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe 
                245                 250                 255     


Pro Pro Glu Ala Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu 
            260                 265                 270         


Lys His Asp Val Val Phe Leu Ile Thr Lys Tyr Gly Tyr Ile His Leu 
        275                 280                 285             


Tyr Asp Leu Glu Thr Gly Thr Cys Ile Tyr Met Asn Arg Ile Ser Gly 
    290                 295                 300                 


Glu Thr Ile Phe Val Thr Ala Pro His Glu Ala Thr Ala Gly Ile Ile 
305                 310                 315                 320 


Gly Val Asn Arg Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu 
                325                 330                 335     


Asn Ile Ile Pro Tyr Ile Thr Asn Val Leu Gln Asn Pro Asp Leu Ala 
            340                 345                 350         


Leu Arg Met Ala Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe 
        355                 360                 365             


Ala Arg Lys Phe Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala 
    370                 375                 380                 


Ala Lys Val Ala Ala Asn Ala Pro Lys Gly Ile Leu Arg Thr Pro Asp 
385                 390                 395                 400 


Thr Ile Arg Arg Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Thr Ser 
                405                 410                 415     


Pro Leu Leu Gln Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn 
            420                 425                 430         


Lys Tyr Glu Ser Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg 
        435                 440                 445             


Lys Gln Leu Leu Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser 
    450                 455                 460                 


Glu Glu Leu Gly Asp Leu Val Lys Ser Val Asp Pro Thr Leu Ala Leu 
465                 470                 475                 480 


Ser Val Tyr Leu Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe 
                485                 490                 495     


Ala Glu Thr Gly Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val 
            500                 505                 510         


Gly Tyr Thr Pro Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile 
        515                 520                 525             


Ser Pro Asp Gln Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu 
    530                 535                 540                 


Glu Pro Leu Ala Asp Ile Thr Gln Ile Val Asp Val Phe Met Glu Tyr 
545                 550                 555                 560 


Asn Leu Ile Gln Gln Cys Thr Ala Phe Leu Leu Asp Ala Leu Lys Asn 
                565                 570                 575     


Asn Arg Pro Ser Glu Gly Pro Leu Gln Thr Arg Leu Leu Glu Met Asn 
            580                 585                 590         


Leu Met His Ala Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met 
        595                 600                 605             


Phe Thr His Tyr Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala 
    610                 615                 620                 


Gly Leu Leu Gln Arg Ala Leu Glu His Phe Thr Asp Leu Tyr Asp Ile 
625                 630                 635                 640 


Lys Arg Ala Val Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val 
                645                 650                 655     


Asn Tyr Phe Gly Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg 
            660                 665                 670         


Ala Met Leu Ser Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln 
        675                 680                 685             


Val Ala Ser Lys Tyr His Glu Gln Leu Ser Thr Gln Ser Leu Ile Glu 
    690                 695                 700                 


Leu Phe Glu Ser Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly 
705                 710                 715                 720 


Ser Ile Val Asn Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile 
                725                 730                 735     


Gln Ala Ala Cys Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys 
            740                 745                 750         


Arg Glu Ser Asn Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys 
        755                 760                 765             


Glu Ala Lys Leu Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg 
    770                 775                 780                 


Phe Asp Phe Val His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu 
785                 790                 795                 800 


Gln Lys Tyr Ile Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu 
                805                 810                 815     


Pro Val Val Ile Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val 
            820                 825                 830         


Ile Lys Asn Leu Ile Leu Val Val Arg Gly Gln Phe Ser Thr Asp Glu 
        835                 840                 845             


Leu Val Ala Glu Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro 
    850                 855                 860                 


Trp Leu Glu Ala Arg Ile His Glu Gly Cys Glu Glu Pro Ala Thr His 
865                 870                 875                 880 


Asn Ala Leu Ala Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg 
                885                 890                 895     


Phe Leu Arg Glu Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr 
            900                 905                 910         


Cys Glu Lys Arg Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly 
        915                 920                 925             


Gln Cys Asp Leu Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe 
    930                 935                 940                 


Lys Ser Leu Ser Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp 
945                 950                 955                 960 


Gly Ser Val Leu Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp 
                965                 970                 975     


Gln Val Val Gln Thr Ala Leu Ser Glu Thr Gln Asp Pro Glu Glu Val 
            980                 985                 990         


Ser Val Thr Val Lys Ala Phe Met  Thr Ala Asp Leu Pro  Asn Glu Leu 
        995                 1000                 1005             


Ile Glu  Leu Leu Glu Lys Ile  Val Leu Asp Asn Ser  Val Phe Ser 
    1010                 1015                 1020             


Glu His  Arg Asn Leu Gln Asn  Leu Leu Ile Leu Thr  Ala Ile Lys 
    1025                 1030                 1035             


Ala Asp  Arg Thr Arg Val Met  Glu Tyr Ile Asn Arg  Leu Asp Asn 
    1040                 1045                 1050             


Tyr Asp  Ala Pro Asp Ile Ala  Asn Ile Ala Ile Ser  Asn Glu Leu 
    1055                 1060                 1065             


Phe Glu  Glu Ala Phe Ala Ile  Phe Arg Lys Phe Asp  Val Asn Thr 
    1070                 1075                 1080             


Ser Ala  Val Gln Val Leu Ile  Glu His Ile Gly Asn  Leu Asp Arg 
    1085                 1090                 1095             


Ala Tyr  Glu Phe Ala Glu Arg  Cys Asn Glu Pro Ala  Val Trp Ser 
    1100                 1105                 1110             


Gln Leu  Ala Lys Ala Gln Leu  Gln Lys Gly Met Val  Lys Glu Ala 
    1115                 1120                 1125             


Ile Asp  Ser Tyr Ile Lys Ala  Asp Asp Pro Ser Ser  Tyr Met Glu 
    1130                 1135                 1140             


Val Val  Gln Ala Ala Asn Thr  Ser Gly Asn Trp Glu  Glu Leu Val 
    1145                 1150                 1155             


Lys Tyr  Leu Gln Met Ala Arg  Lys Lys Ala Arg Glu  Ser Tyr Val 
    1160                 1165                 1170             


Glu Thr  Glu Leu Ile Phe Ala  Leu Ala Lys Thr Asn  Arg Leu Ala 
    1175                 1180                 1185             


Glu Leu  Glu Glu Phe Ile Asn  Gly Pro Asn Asn Ala  His Ile Gln 
    1190                 1195                 1200             


Gln Val  Gly Asp Arg Cys Tyr  Asp Glu Lys Met Tyr  Asp Ala Ala 
    1205                 1210                 1215             


Lys Leu  Leu Tyr Asn Asn Val  Ser Asn Phe Gly Arg  Leu Ala Ser 
    1220                 1225                 1230             


Thr Leu  Val His Leu Gly Glu  Tyr Gln Ala Ala Val  Asp Gly Ala 
    1235                 1240                 1245             


Arg Lys  Ala Asn Ser Thr Arg  Thr Trp Lys Glu Val  Cys Phe Ala 
    1250                 1255                 1260             


Cys Val  Asp Gly Lys Glu Phe  Arg Leu Ala Gln Met  Cys Gly Leu 
    1265                 1270                 1275             


His Ile  Val Val His Ala Asp  Glu Leu Glu Glu Leu  Ile Asn Tyr 
    1280                 1285                 1290             


Tyr Gln  Asp Arg Gly Tyr Phe  Glu Glu Leu Ile Thr  Met Leu Glu 
    1295                 1300                 1305             


Ala Ala  Leu Gly Leu Glu Arg  Ala His Met Gly Met  Phe Thr Glu 
    1310                 1315                 1320             


Leu Ala  Ile Leu Tyr Ser Lys  Phe Lys Pro Gln Lys  Met Arg Glu 
    1325                 1330                 1335             


His Leu  Glu Leu Phe Trp Ser  Arg Val Asn Ile Pro  Lys Val Leu 
    1340                 1345                 1350             


Arg Ala  Ala Glu Gln Ala His  Leu Trp Ala Glu Leu  Val Phe Leu 
    1355                 1360                 1365             


Tyr Asp  Lys Tyr Glu Glu Tyr  Asp Asn Ala Ile Ile  Thr Met Met 
    1370                 1375                 1380             


Asn His  Pro Thr Asp Ala Trp  Lys Glu Gly Gln Phe  Lys Asp Ile 
    1385                 1390                 1395             


Ile Thr  Lys Val Ala Asn Val  Glu Leu Tyr Tyr Arg  Ala Ile Gln 
    1400                 1405                 1410             


Phe Tyr  Leu Glu Phe Lys Pro  Leu Leu Leu Asn Asp  Leu Leu Met 
    1415                 1420                 1425             


Val Leu  Ser Pro Arg Leu Asp  His Thr Arg Ala Val  Asn Tyr Phe 
    1430                 1435                 1440             


Ser Lys  Val Lys Gln Leu Pro  Leu Val Lys Pro Tyr  Leu Arg Ser 
    1445                 1450                 1455             


Val Gln  Asn His Asn Asn Lys  Ser Val Asn Glu Ser  Leu Asn Asn 
    1460                 1465                 1470             


Leu Phe  Ile Thr Glu Glu Asp  Tyr Gln Ala Leu Arg  Thr Ser Ile 
    1475                 1480                 1485             


Asp Ala  Tyr Asp Asn Phe Asp  Asn Ile Ser Leu Ala  Gln Arg Leu 
    1490                 1495                 1500             


Glu Lys  His Glu Leu Ile Glu  Phe Arg Arg Ile Ala  Ala Tyr Leu 
    1505                 1510                 1515             


Phe Lys  Gly Asn Asn Arg Trp  Lys Gln Ser Val Glu  Leu Cys Lys 
    1520                 1525                 1530             


Lys Asp  Ser Leu Tyr Lys Asp  Ala Met Gln Tyr Ala  Ser Glu Ser 
    1535                 1540                 1545             


Lys Asp  Thr Glu Leu Ala Glu  Glu Leu Leu Gln Trp  Phe Leu Gln 
    1550                 1555                 1560             


Glu Glu  Lys Arg Glu Cys Phe  Gly Ala Cys Leu Phe  Thr Cys Tyr 
    1565                 1570                 1575             


Asp Leu  Leu Arg Pro Asp Val  Val Leu Glu Thr Ala  Trp Arg His 
    1580                 1585                 1590             


Asn Ile  Met Asp Phe Ala Met  Pro Tyr Phe Ile Gln  Val Met Lys 
    1595                 1600                 1605             


Glu Tyr  Leu Thr Lys Val Asp  Lys Leu Asp Ala Ser  Glu Ser Leu 
    1610                 1615                 1620             


Arg Lys  Glu Glu Glu Gln Ala  Thr Glu Thr Gln Pro  Ile Val Tyr 
    1625                 1630                 1635             


Gly Gln  Pro Gln Leu Met Leu  Thr Ala Gly Pro Ser  Val Ala Val 
    1640                 1645                 1650             


Pro Pro  Gln Ala Pro Phe Gly  Tyr Gly Tyr Thr Ala  Pro Pro Tyr 
    1655                 1660                 1665             


Gly Gln  Pro Gln Pro Gly Phe  Gly Tyr Ser Met 
    1670                 1675                 


<210>  8
<211>  1569
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/AAB40909
<309>  1997-01-15
<313>  (1)..(1569)

<400>  8

Met Ala Gln Ile Leu Pro Val Arg Phe Gln Glu His Phe Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Thr Ile Ile Asp Met Ser Asp Pro Met Ala Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Glu Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Ala Glu Glu Val Ile Phe Trp Lys 
            100                 105                 110         


Trp Val Ser Val Asn Thr Val Ala Leu Val Thr Glu Thr Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Asp Ser Gln Pro Met Lys Met Phe Asp Arg 
    130                 135                 140                 


His Thr Ser Leu Val Gly Cys Gln Val Ile His Tyr Arg Thr Asp Glu 
145                 150                 155                 160 


Tyr Gln Lys Trp Leu Leu Leu Val Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ala Phe Ala Glu Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Lys Pro Ala Thr Leu Phe Cys Phe Ala Val Arg Asn Pro Thr 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Gln Pro Ala Ala Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Val Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Gly Ala Lys His Gly Val 
            260                 265                 270         


Ile Tyr Leu Ile Thr Lys Tyr Gly Tyr Leu His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Ser Gly Val Cys Ile Cys Met Asn Arg Ile Ser Ala Asp Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Lys Pro Thr Ser Gly Ile Ile Gly Val Asn Lys 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Asp Asn Ile Val Asn 
                325                 330                 335     


Tyr Ala Thr Asn Val Leu Gln Asn Pro Asp Leu Gly Leu Arg Leu Ala 
            340                 345                 350         


Val Arg Ser Asn Leu Ala Gly Ala Glu Lys Leu Phe Val Arg Lys Phe 
        355                 360                 365             


Asn Thr Leu Phe Ala Gln Gly Ser Tyr Ala Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Ser Ala Pro Lys Gly Ile Leu Arg Thr Arg Glu Thr Val Gln Lys 
385                 390                 395                 400 


Phe Gln Ser Ile Pro Ala Gln Ser Gly Gln Ala Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Leu Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys His Leu Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Thr Thr Asp Pro Met Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Ser Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Phe Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Gly Val Met Lys Ile Ser Pro Glu Gln 
        515                 520                 525             


Gly Leu Gln Phe Ser Arg Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asn Ile Ser Gln Ile Val Asp Ile Phe Met Glu Asn Ser Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ser Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ala 
                565                 570                 575     


Glu Gly Leu Leu Gln Thr Trp Leu Leu Glu Met Asn Leu Val His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Lys Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Gln Ala Leu Glu His Tyr Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Phe Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Val Glu Cys Leu His Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Leu Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Lys Gln Leu Gly Thr Gln Ala Leu Val Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Tyr Lys Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Leu Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Ser 
            740                 745                 750         


Cys Tyr Asn Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Gly Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Arg Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Thr Pro Ala Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Glu Val Ile Lys His Leu 
            820                 825                 830         


Ile Met Ala Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ser 
    850                 855                 860                 


Gln Ile Gln Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Ser Pro Glu Cys Phe Leu Arg Glu 
                885                 890                 895     


Asn Ala Tyr Tyr Asp Ser Ser Val Val Gly Arg Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Lys Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Glu Ala 
    930                 935                 940                 


Arg Tyr Leu Val Cys Arg Lys Asp Pro Glu Leu Trp Ala His Val Leu 
945                 950                 955                 960 


Glu Glu Thr Asn Pro Ser Arg Arg Gln Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Arg Asp Pro Glu Glu Ile Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Ser  Arg Leu Asp Asn Tyr  Asp Ala Leu 
    1040                 1045                 1050             


Asp Ile  Ala Ser Ile Ala Val  Ser Ser Ala Leu Tyr  Glu Glu Ala 
    1055                 1060                 1065             


Phe Thr  Val Phe His Lys Phe  Asp Met Asn Ala Ser  Ala Ile Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Gln 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Asp Leu  Val Lys Glu Ala Ile  Asn Ser Tyr 
    1115                 1120                 1125             


Ile Arg  Gly Asp Asp Pro Ser  Ser Tyr Leu Glu Val  Val Gln Ser 
    1130                 1135                 1140             


Ala Ser  Arg Ser Asn Asn Trp  Glu Asp Leu Val Lys  Phe Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Gly Arg  Glu Ser Tyr Ile Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Ser Arg Val Ser Glu  Leu Glu Asp 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Glu Glu Gly Met  Tyr Glu Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Ser Asn  Val Ser Asn Phe Ala  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Asn Ser Arg  Lys Ala Ser 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Met Asp Gly 
    1250                 1255                 1260             


Gln Glu  Phe Arg Phe Ala Gln  Leu Cys Gly Leu His  Ile Val Ile 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Met Cys Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Leu Leu Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Leu Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Val  Leu Thr Met Met Ser  His Pro Thr 
    1370                 1375                 1380             


Glu Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Cys Tyr  Arg Ala Leu Gln Phe  Tyr Leu Asp 
    1400                 1405                 1410             


Tyr Lys  Pro Leu Leu Ile Asn  Asp Leu Leu Leu Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Trp Thr  Val Ser Phe Phe Ser  Lys Ala Gly 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Ser His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ala Leu Asn His Leu  Leu Thr Glu 
    1460                 1465                 1470             


Lys Glu  Asp Tyr Gln Asp Ala  Met Gln His Ala Ala  Glu Ser Arg 
    1475                 1480                 1485             


Asp Ala  Glu Leu Ala Gln Lys  Leu Leu Gln Trp Phe  Leu Glu Glu 
    1490                 1495                 1500             


Gly Lys  Arg Glu Cys Phe Ala  Ala Cys Leu Phe Thr  Cys Tyr Asp 
    1505                 1510                 1515             


Leu Leu  Arg Pro Asp Met Val  Leu Glu Leu Ala Trp  Arg His Asn 
    1520                 1525                 1530             


Leu Val  Asp Leu Ala Met Pro  Tyr Phe Ile Gln Val  Met Arg Glu 
    1535                 1540                 1545             


Tyr Leu  Ser Lys Val Asp Lys  Leu Asp Ala Leu Glu  Ser Leu Pro 
    1550                 1555                 1560             


Pro Ser  Lys Arg Ser Met 
    1565                 


<210>  9
<211>  1639
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/AAH51800
<309>  2006-10-06
<313>  (1)..(1639)

<400>  9

Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Thr Asp Asp Val Thr Phe Trp Lys 
            100                 105                 110         


Trp Ile Ser Leu Asn Thr Val Ala Leu Val Thr Asp Asn Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys Met Phe Asp Arg 
    130                 135                 140                 


His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr Arg Thr Asp Ala 
145                 150                 155                 160 


Lys Gln Lys Trp Leu Leu Leu Thr Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Glu Glu Ser Thr Leu Phe Cys Phe Ala Val Arg Gly Gln Ala 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Thr Pro Pro Thr Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu Lys His Asp Val 
            260                 265                 270         


Val Phe Leu Ile Thr Lys Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Thr Gly Thr Cys Ile Tyr Met Asn Arg Ile Ser Gly Glu Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Glu Ala Thr Ala Gly Ile Ile Gly Val Asn Arg 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu Asn Ile Ile Pro 
                325                 330                 335     


Tyr Ile Thr Asn Val Leu Gln Asn Pro Asp Leu Ala Leu Arg Met Ala 
            340                 345                 350         


Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe 
        355                 360                 365             


Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Asn Ala Pro Lys Gly Ile Leu Arg Thr Pro Asp Thr Ile Arg Arg 
385                 390                 395                 400 


Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Thr Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Ser Val Asp Pro Thr Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile Ser Pro Asp Gln 
        515                 520                 525             


Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asp Ile Thr Gln Ile Val Asp Val Phe Met Glu Tyr Asn Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ala Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser 
                565                 570                 575     


Glu Gly Pro Leu Gln Thr Arg Leu Leu Glu Met Asn Leu Met His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Arg Ala Leu Glu His Phe Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Ser Thr Gln Ser Leu Ile Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Asn 
            740                 745                 750         


Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Asp Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu Pro Val Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val Ile Lys Asn Leu 
            820                 825                 830         


Ile Leu Val Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala 
    850                 855                 860                 


Arg Ile His Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu 
                885                 890                 895     


Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser 
    930                 935                 940                 


Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp Gly Ser Val Leu 
945                 950                 955                 960 


Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Gln Asp Pro Glu Glu Val Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Asn  Arg Leu Asp Asn Tyr  Asp Ala Pro 
    1040                 1045                 1050             


Asp Ile  Ala Asn Ile Ala Ile  Ser Asn Glu Leu Phe  Glu Glu Ala 
    1055                 1060                 1065             


Phe Ala  Ile Phe Arg Lys Phe  Asp Val Asn Thr Ser  Ala Val Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Lys 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Gly Met  Val Lys Glu Ala Ile  Asp Ser Tyr 
    1115                 1120                 1125             


Ile Lys  Ala Asp Asp Pro Ser  Ser Tyr Met Glu Val  Val Gln Ala 
    1130                 1135                 1140             


Ala Asn  Thr Ser Gly Asn Trp  Glu Glu Leu Val Lys  Tyr Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Ala Arg  Glu Ser Tyr Val Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Asn Arg Leu Ala Glu  Leu Glu Glu 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Asp Glu Lys Met  Tyr Asp Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Asn Asn  Val Ser Asn Phe Gly  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Gly Ala Arg  Lys Ala Asn 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Val Asp Gly 
    1250                 1255                 1260             


Lys Glu  Phe Arg Leu Ala Gln  Met Cys Gly Leu His  Ile Val Val 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Ile Asn Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Thr Met Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Arg Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Ile  Ile Thr Met Met Asn  His Pro Thr 
    1370                 1375                 1380             


Asp Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Tyr Tyr  Arg Ala Ile Gln Phe  Tyr Leu Glu 
    1400                 1405                 1410             


Phe Lys  Pro Leu Leu Leu Asn  Asp Leu Leu Met Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Arg Ala  Val Asn Tyr Phe Ser  Lys Val Lys 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Asn His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ser Leu Asn Asn Leu  Phe Ile Thr 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Ala Leu  Arg Thr Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Arg Leu Glu  Lys His Glu 
    1490                 1495                 1500             


Leu Ile  Glu Phe Arg Arg Ile  Ala Ala Tyr Leu Phe  Lys Gly Asn 
    1505                 1510                 1515             


Asn Arg  Trp Lys Gln Ser Val  Glu Leu Cys Lys Lys  Asp Ser Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln Tyr  Ala Ser Glu Ser Lys  Asp Thr Glu 
    1535                 1540                 1545             


Leu Ala  Glu Glu Leu Leu Gln  Trp Phe Leu Gln Glu  Glu Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Gly Ala Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Val Val Leu Glu Thr  Ala Trp Arg His Asn  Ile Met Asp 
    1580                 1585                 1590             


Phe Ala  Met Pro Tyr Phe Ile  Gln Val Met Lys Glu  Tyr Leu Thr 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Ser Glu Ser Leu Arg  Lys Glu Glu 
    1610                 1615                 1620             


Glu Gln  Ala Thr Glu Thr Gln  Pro Ile Val Tyr Gly  Asn Leu Ser 
    1625                 1630                 1635             


Leu 
    


<210>  10
<211>  1626
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/AAB40908
<309>  1997-01-15
<313>  (1)..(1626)

<400>  10

Met Ala Gln Ile Leu Pro Val Arg Phe Gln Glu His Phe Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Thr Ile Ile Asp Met Ser Asp Pro Met Ala Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Glu Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Ala Glu Glu Val Ile Phe Trp Lys 
            100                 105                 110         


Trp Val Ser Val Asn Thr Val Ala Leu Val Thr Glu Thr Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Asp Ser Gln Pro Met Lys Met Phe Asp Arg 
    130                 135                 140                 


His Thr Ser Leu Val Gly Cys Gln Val Ile His Tyr Arg Thr Asp Glu 
145                 150                 155                 160 


Tyr Gln Lys Trp Leu Leu Leu Val Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ala Phe Ala Glu Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Lys Pro Ala Thr Leu Phe Cys Phe Ala Val Arg Asn Pro Thr 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Gln Pro Ala Ala Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Val Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Gly Ala Lys His Gly Val 
            260                 265                 270         


Ile Tyr Leu Ile Thr Lys Tyr Gly Tyr Leu His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Ser Gly Val Cys Ile Cys Met Asn Arg Ile Ser Ala Asp Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Lys Pro Thr Ser Gly Ile Ile Gly Val Asn Lys 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Asp Asn Ile Val Asn 
                325                 330                 335     


Tyr Ala Thr Asn Val Leu Gln Asn Pro Asp Leu Gly Leu Arg Leu Ala 
            340                 345                 350         


Val Arg Ser Asn Leu Ala Gly Ala Glu Lys Leu Phe Val Arg Lys Phe 
        355                 360                 365             


Asn Thr Leu Phe Ala Gln Gly Ser Tyr Ala Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Ser Ala Pro Lys Gly Ile Leu Arg Thr Arg Glu Thr Val Gln Lys 
385                 390                 395                 400 


Phe Gln Ser Ile Pro Ala Gln Ser Gly Gln Ala Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Leu Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys His Leu Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Thr Thr Asp Pro Met Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Ser Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Phe Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Gly Val Met Lys Ile Ser Pro Glu Gln 
        515                 520                 525             


Gly Leu Gln Phe Ser Arg Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asn Ile Ser Gln Ile Val Asp Ile Phe Met Glu Asn Ser Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ser Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ala 
                565                 570                 575     


Glu Gly Leu Leu Gln Thr Trp Leu Leu Glu Met Asn Leu Val His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Lys Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Gln Ala Leu Glu His Tyr Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Phe Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Val Glu Cys Leu His Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Leu Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Lys Gln Leu Gly Thr Gln Ala Leu Val Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Tyr Lys Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Leu Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Ser 
            740                 745                 750         


Cys Tyr Asn Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Gly Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Arg Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Thr Pro Ala Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Glu Val Ile Lys His Leu 
            820                 825                 830         


Ile Met Ala Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ser 
    850                 855                 860                 


Gln Ile Gln Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Ser Pro Glu Cys Phe Leu Arg Glu 
                885                 890                 895     


Asn Ala Tyr Tyr Asp Ser Ser Val Val Gly Arg Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Lys Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Glu Ala 
    930                 935                 940                 


Arg Tyr Leu Val Cys Arg Lys Asp Pro Glu Leu Trp Ala His Val Leu 
945                 950                 955                 960 


Glu Glu Thr Asn Pro Ser Arg Arg Gln Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Arg Asp Pro Glu Glu Ile Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Ser  Arg Leu Asp Asn Tyr  Asp Ala Leu 
    1040                 1045                 1050             


Asp Ile  Ala Ser Ile Ala Val  Ser Ser Ala Leu Tyr  Glu Glu Ala 
    1055                 1060                 1065             


Phe Thr  Val Phe His Lys Phe  Asp Met Asn Ala Ser  Ala Ile Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Gln 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Asp Leu  Val Lys Glu Ala Ile  Asn Ser Tyr 
    1115                 1120                 1125             


Ile Arg  Gly Asp Asp Pro Ser  Ser Tyr Leu Glu Val  Val Gln Ser 
    1130                 1135                 1140             


Ala Ser  Arg Ser Asn Asn Trp  Glu Asp Leu Val Lys  Phe Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Gly Arg  Glu Ser Tyr Ile Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Ser Arg Val Ser Glu  Leu Glu Asp 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Glu Glu Gly Met  Tyr Glu Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Ser Asn  Val Ser Asn Phe Ala  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Asn Ser Arg  Lys Ala Ser 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Met Asp Gly 
    1250                 1255                 1260             


Gln Glu  Phe Arg Phe Ala Gln  Leu Cys Gly Leu His  Ile Val Ile 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Met Cys Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Leu Leu Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Leu Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Val  Leu Thr Met Met Ser  His Pro Thr 
    1370                 1375                 1380             


Glu Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Cys Tyr  Arg Ala Leu Gln Phe  Tyr Leu Asp 
    1400                 1405                 1410             


Tyr Lys  Pro Leu Leu Ile Asn  Asp Leu Leu Leu Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Trp Thr  Val Ser Phe Phe Ser  Lys Ala Gly 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Ser His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ala Leu Asn His Leu  Leu Thr Glu 
    1460                 1465                 1470             


Lys Glu  Asp Tyr Gln Gly Leu  Arg Ala Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Gln Leu Glu  Lys His Gln 
    1490                 1495                 1500             


Leu Met  Glu Phe Arg Cys Ile  Ala Ala Tyr Leu Tyr  Lys Gly Asn 
    1505                 1510                 1515             


Asn Trp  Trp Ala Gln Ser Val  Glu Leu Cys Lys Lys  Asp His Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln His  Ala Ala Glu Ser Arg  Asp Ala Glu 
    1535                 1540                 1545             


Leu Ala  Gln Lys Leu Leu Gln  Trp Phe Leu Glu Glu  Gly Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Ala Ala Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Met Val Leu Glu Leu  Ala Trp Arg His Asn  Leu Val Asp 
    1580                 1585                 1590             


Leu Ala  Met Pro Tyr Phe Ile  Gln Val Met Arg Glu  Tyr Leu Ser 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Leu Glu Ser Leu Pro  Pro Ser Lys 
    1610                 1615                 1620             


Arg Ser  Met 
    1625     


<210>  11
<211>  1639
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/EAW94398
<309>  2006-12-18
<313>  (1)..(1639)

<400>  11

Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Thr Asp Asp Val Thr Phe Trp Lys 
            100                 105                 110         


Trp Ile Ser Leu Asn Thr Val Ala Leu Val Thr Asp Asn Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys Met Phe Asp Arg 
    130                 135                 140                 


His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr Arg Thr Asp Ala 
145                 150                 155                 160 


Lys Gln Lys Trp Leu Leu Leu Thr Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Glu Glu Ser Thr Leu Phe Cys Phe Ala Val Arg Gly Gln Ala 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Thr Pro Pro Thr Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu Lys His Asp Val 
            260                 265                 270         


Val Phe Leu Ile Thr Lys Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Thr Gly Thr Cys Ile Tyr Met Asn Arg Ile Ser Gly Glu Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Glu Ala Thr Ala Gly Ile Ile Gly Val Asn Arg 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu Asn Ile Ile Pro 
                325                 330                 335     


Tyr Ile Thr Asn Val Leu Gln Asn Pro Asp Leu Ala Leu Arg Met Ala 
            340                 345                 350         


Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe 
        355                 360                 365             


Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Asn Ala Pro Lys Gly Ile Leu Arg Thr Pro Asp Thr Ile Arg Arg 
385                 390                 395                 400 


Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Thr Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Ser Val Asp Pro Thr Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile Ser Pro Asp Gln 
        515                 520                 525             


Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asp Ile Thr Gln Ile Val Asp Val Phe Met Glu Tyr Asn Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ala Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser 
                565                 570                 575     


Glu Gly Pro Leu Gln Thr Arg Leu Leu Glu Met Asn Leu Met His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Arg Ala Leu Glu His Phe Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Ser Thr Gln Ser Leu Ile Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Asn 
            740                 745                 750         


Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Asp Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu Pro Val Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val Ile Lys Asn Leu 
            820                 825                 830         


Ile Leu Val Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala 
    850                 855                 860                 


Arg Ile His Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu 
                885                 890                 895     


Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser 
    930                 935                 940                 


Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp Gly Ser Val Leu 
945                 950                 955                 960 


Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Gln Asp Pro Glu Glu Val Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Asn  Arg Leu Asp Asn Tyr  Asp Ala Pro 
    1040                 1045                 1050             


Asp Ile  Ala Asn Ile Ala Ile  Ser Asn Glu Leu Phe  Glu Glu Ala 
    1055                 1060                 1065             


Phe Ala  Ile Phe Arg Lys Phe  Asp Val Asn Thr Ser  Ala Val Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Lys 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Gly Met  Val Lys Glu Ala Ile  Asp Ser Tyr 
    1115                 1120                 1125             


Ile Lys  Ala Asp Asp Pro Ser  Ser Tyr Met Glu Val  Val Gln Ala 
    1130                 1135                 1140             


Ala Asn  Thr Ser Gly Asn Trp  Glu Glu Leu Val Lys  Tyr Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Ala Arg  Glu Ser Tyr Val Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Asn Arg Leu Ala Glu  Leu Glu Glu 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Asp Glu Lys Met  Tyr Asp Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Asn Asn  Val Ser Asn Phe Gly  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Gly Ala Arg  Lys Ala Asn 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Val Asp Gly 
    1250                 1255                 1260             


Lys Glu  Phe Arg Leu Ala Gln  Met Cys Gly Leu His  Ile Val Val 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Ile Asn Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Thr Met Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Arg Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Ile  Ile Thr Met Met Asn  His Pro Thr 
    1370                 1375                 1380             


Asp Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Tyr Tyr  Arg Ala Ile Gln Phe  Tyr Leu Glu 
    1400                 1405                 1410             


Phe Lys  Pro Leu Leu Leu Asn  Asp Leu Leu Met Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Arg Ala  Val Asn Tyr Phe Ser  Lys Val Lys 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Asn His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ser Leu Asn Asn Leu  Phe Ile Thr 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Ala Leu  Arg Thr Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Arg Leu Glu  Lys His Glu 
    1490                 1495                 1500             


Leu Ile  Glu Phe Arg Arg Ile  Ala Ala Tyr Leu Phe  Lys Gly Asn 
    1505                 1510                 1515             


Asn Arg  Trp Lys Gln Ser Val  Glu Leu Cys Lys Lys  Asp Ser Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln Tyr  Ala Ser Glu Ser Lys  Asp Thr Glu 
    1535                 1540                 1545             


Leu Ala  Glu Glu Leu Leu Gln  Trp Phe Leu Gln Glu  Glu Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Gly Ala Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Val Val Leu Glu Thr  Ala Trp Arg His Asn  Ile Met Asp 
    1580                 1585                 1590             


Phe Ala  Met Pro Tyr Phe Ile  Gln Val Met Lys Glu  Tyr Leu Thr 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Ser Glu Ser Leu Arg  Lys Glu Glu 
    1610                 1615                 1620             


Glu Gln  Ala Thr Glu Thr Gln  Pro Ile Val Tyr Gly  Asn Leu Ser 
    1625                 1630                 1635             


Leu 
    


<210>  12
<211>  248
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProtKB/P09496
<309>  2009-05-26
<313>  (1)..(248)

<400>  12

Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
1               5                   10                  15      


Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
            20                  25                  30          


Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
        35                  40                  45              


Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
    50                  55                  60                  


His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
65                  70                  75                  80  


Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Thr Asp Ser Tyr Ala Ala 
                85                  90                  95      


Ile Ser Gln Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
            100                 105                 110         


Trp Arg Glu Glu Gln Met Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
        115                 120                 125             


Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu 
    130                 135                 140                 


Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Thr Lys Ala Asn 
145                 150                 155                 160 


Asn Arg Val Ala Asp Glu Ala Phe Tyr Lys Gln Pro Phe Ala Asp Val 
                165                 170                 175     


Ile Gly Tyr Val Thr Asn Ile Asn His Pro Cys Tyr Ser Leu Glu Gln 
            180                 185                 190         


Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Glu Ser Ser Pro Gly 
        195                 200                 205             


Thr Glu Trp Glu Arg Val Ala Arg Leu Cys Asp Phe Asn Pro Lys Ser 
    210                 215                 220                 


Ser Lys Gln Ala Lys Asp Val Ser Arg Met Arg Ser Val Leu Ile Ser 
225                 230                 235                 240 


Leu Lys Gln Ala Pro Leu Val His 
                245             


<210>  13
<211>  229
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProtKB/P09497
<309>  2009-05-26
<313>  (1)..(229)

<400>  13

Met Ala Asp Asp Phe Gly Phe Phe Ser Ser Ser Glu Ser Gly Ala Pro 
1               5                   10                  15      


Glu Ala Ala Glu Glu Asp Pro Ala Ala Ala Phe Leu Ala Gln Gln Glu 
            20                  25                  30          


Ser Glu Ile Ala Gly Ile Glu Asn Asp Glu Gly Phe Gly Ala Pro Ala 
        35                  40                  45              


Gly Ser His Ala Ala Pro Ala Gln Pro Gly Pro Thr Ser Gly Ala Gly 
    50                  55                  60                  


Ser Glu Asp Met Gly Thr Thr Val Asn Gly Asp Val Phe Gln Glu Ala 
65                  70                  75                  80  


Asn Gly Pro Ala Asp Gly Tyr Ala Ala Ile Ala Gln Ala Asp Arg Leu 
                85                  90                  95      


Thr Gln Glu Pro Glu Ser Ile Arg Lys Trp Arg Glu Glu Gln Arg Lys 
            100                 105                 110         


Arg Leu Gln Glu Leu Asp Ala Ala Ser Lys Val Thr Glu Gln Glu Trp 
        115                 120                 125             


Arg Glu Lys Ala Lys Lys Asp Leu Glu Glu Trp Asn Gln Arg Gln Ser 
    130                 135                 140                 


Glu Gln Val Glu Lys Asn Lys Ile Asn Asn Arg Ile Ala Asp Lys Ala 
145                 150                 155                 160 


Phe Tyr Gln Gln Pro Asp Ala Asp Ile Ile Gly Tyr Val Ala Ser Glu 
                165                 170                 175     


Glu Ala Phe Val Lys Glu Ser Lys Glu Glu Thr Pro Gly Thr Glu Trp 
            180                 185                 190         


Glu Lys Val Ala Gln Leu Cys Asp Phe Asn Pro Lys Ser Ser Lys Gln 
        195                 200                 205             


Cys Lys Asp Val Ser Arg Leu Arg Ser Val Leu Met Ser Leu Lys Gln 
    210                 215                 220                 


Thr Pro Leu Ser Arg 
225                 


<210>  14
<211>  236
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/NP_001070145
<309>  2008-05-01
<313>  (1)..(236)

<400>  14

Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
1               5                   10                  15      


Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
            20                  25                  30          


Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
        35                  40                  45              


Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
    50                  55                  60                  


His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
65                  70                  75                  80  


Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Thr Asp Ser Tyr Ala Ala 
                85                  90                  95      


Ile Ser Gln Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
            100                 105                 110         


Trp Arg Glu Glu Gln Met Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
        115                 120                 125             


Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu 
    130                 135                 140                 


Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Thr Lys Ala Asn 
145                 150                 155                 160 


Asn Arg Val Ala Asp Glu Ala Phe Tyr Lys Gln Pro Phe Ala Asp Val 
                165                 170                 175     


Ile Gly Tyr Val Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Glu 
            180                 185                 190         


Ser Ser Pro Gly Thr Glu Trp Glu Arg Val Ala Arg Leu Cys Asp Phe 
        195                 200                 205             


Asn Pro Lys Ser Ser Lys Gln Ala Lys Asp Val Ser Arg Met Arg Ser 
    210                 215                 220                 


Val Leu Ile Ser Leu Lys Gln Ala Pro Leu Val His 
225                 230                 235     


<210>  15
<211>  1224
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProtKB/P53621
<309>  2009-05-26
<313>  (1)..(1224)

<400>  15

Met Leu Thr Lys Phe Glu Thr Lys Ser Ala Arg Val Lys Gly Leu Ser 
1               5                   10                  15      


Phe His Pro Lys Arg Pro Trp Ile Leu Thr Ser Leu His Asn Gly Val 
            20                  25                  30          


Ile Gln Leu Trp Asp Tyr Arg Met Cys Thr Leu Ile Asp Lys Phe Asp 
        35                  40                  45              


Glu His Asp Gly Pro Val Arg Gly Ile Asp Phe His Lys Gln Gln Pro 
    50                  55                  60                  


Leu Phe Val Ser Gly Gly Asp Asp Tyr Lys Ile Lys Val Trp Asn Tyr 
65                  70                  75                  80  


Lys Leu Arg Arg Cys Leu Phe Thr Leu Leu Gly His Leu Asp Tyr Ile 
                85                  90                  95      


Arg Thr Thr Phe Phe His His Glu Tyr Pro Trp Ile Leu Ser Ala Ser 
            100                 105                 110         


Asp Asp Gln Thr Ile Arg Val Trp Asn Trp Gln Ser Arg Thr Cys Val 
        115                 120                 125             


Cys Val Leu Thr Gly His Asn His Tyr Val Met Cys Ala Gln Phe His 
    130                 135                 140                 


Pro Thr Glu Asp Leu Val Val Ser Ala Ser Leu Asp Gln Thr Val Arg 
145                 150                 155                 160 


Val Trp Asp Ile Ser Gly Leu Arg Lys Lys Asn Leu Ser Pro Gly Ala 
                165                 170                 175     


Val Glu Ser Asp Val Arg Gly Ile Thr Gly Val Asp Leu Phe Gly Thr 
            180                 185                 190         


Thr Asp Ala Val Val Lys His Val Leu Glu Gly His Asp Arg Gly Val 
        195                 200                 205             


Asn Trp Ala Ala Phe His Pro Thr Met Pro Leu Ile Val Ser Gly Ala 
    210                 215                 220                 


Asp Asp Arg Gln Val Lys Ile Trp Arg Met Asn Glu Ser Lys Ala Trp 
225                 230                 235                 240 


Glu Val Asp Thr Cys Arg Gly His Tyr Asn Asn Val Ser Cys Ala Val 
                245                 250                 255     


Phe His Pro Arg Gln Glu Leu Ile Leu Ser Asn Ser Glu Asp Lys Ser 
            260                 265                 270         


Ile Arg Val Trp Asp Met Ser Lys Arg Thr Gly Val Gln Thr Phe Arg 
        275                 280                 285             


Arg Asp His Asp Arg Phe Trp Val Leu Ala Ala His Pro Asn Leu Asn 
    290                 295                 300                 


Leu Phe Ala Ala Gly His Asp Gly Gly Met Ile Val Phe Lys Leu Glu 
305                 310                 315                 320 


Arg Glu Arg Pro Ala Tyr Ala Val His Gly Asn Met Leu His Tyr Val 
                325                 330                 335     


Lys Asp Arg Phe Leu Arg Gln Leu Asp Phe Asn Ser Ser Lys Asp Val 
            340                 345                 350         


Ala Val Met Gln Leu Arg Ser Gly Ser Lys Phe Pro Val Phe Asn Met 
        355                 360                 365             


Ser Tyr Asn Pro Ala Glu Asn Ala Val Leu Leu Cys Thr Arg Ala Ser 
    370                 375                 380                 


Asn Leu Glu Asn Ser Thr Tyr Asp Leu Tyr Thr Ile Pro Lys Asp Ala 
385                 390                 395                 400 


Asp Ser Gln Asn Pro Asp Ala Pro Glu Gly Lys Arg Ser Ser Gly Leu 
                405                 410                 415     


Thr Ala Val Trp Val Ala Arg Asn Arg Phe Ala Val Leu Asp Arg Met 
            420                 425                 430         


His Ser Leu Leu Ile Lys Asn Leu Lys Asn Glu Ile Thr Lys Lys Val 
        435                 440                 445             


Gln Val Pro Asn Cys Asp Glu Ile Phe Tyr Ala Gly Thr Gly Asn Leu 
    450                 455                 460                 


Leu Leu Arg Asp Ala Asp Ser Ile Thr Leu Phe Asp Val Gln Gln Lys 
465                 470                 475                 480 


Arg Thr Leu Ala Ser Val Lys Ile Ser Lys Val Lys Tyr Val Ile Trp 
                485                 490                 495     


Ser Ala Asp Met Ser His Val Ala Leu Leu Ala Lys His Ala Ile Val 
            500                 505                 510         


Ile Cys Asn Arg Lys Leu Asp Ala Leu Cys Asn Ile His Glu Asn Ile 
        515                 520                 525             


Arg Val Lys Ser Gly Ala Trp Asp Glu Ser Gly Val Phe Ile Tyr Thr 
    530                 535                 540                 


Thr Ser Asn His Ile Lys Tyr Ala Val Thr Thr Gly Asp His Gly Ile 
545                 550                 555                 560 


Ile Arg Thr Leu Asp Leu Pro Ile Tyr Val Thr Arg Val Lys Gly Asn 
                565                 570                 575     


Asn Val Tyr Cys Leu Asp Arg Glu Cys Arg Pro Arg Val Leu Thr Ile 
            580                 585                 590         


Asp Pro Thr Glu Phe Lys Phe Lys Leu Ala Leu Ile Asn Arg Lys Tyr 
        595                 600                 605             


Asp Glu Val Leu His Met Val Arg Asn Ala Lys Leu Val Gly Gln Ser 
    610                 615                 620                 


Ile Ile Ala Tyr Leu Gln Lys Lys Gly Tyr Pro Glu Val Ala Leu His 
625                 630                 635                 640 


Phe Val Lys Asp Glu Lys Thr Arg Phe Ser Leu Ala Leu Glu Cys Gly 
                645                 650                 655     


Asn Ile Glu Ile Ala Leu Glu Ala Ala Lys Ala Leu Asp Asp Lys Asn 
            660                 665                 670         


Cys Trp Glu Lys Leu Gly Glu Val Ala Leu Leu Gln Gly Asn His Gln 
        675                 680                 685             


Ile Val Glu Met Cys Tyr Gln Arg Thr Lys Asn Phe Asp Lys Leu Ser 
    690                 695                 700                 


Phe Leu Tyr Leu Ile Thr Gly Asn Leu Glu Lys Leu Arg Lys Met Met 
705                 710                 715                 720 


Lys Ile Ala Glu Ile Arg Lys Asp Met Ser Gly His Tyr Gln Asn Ala 
                725                 730                 735     


Leu Tyr Leu Gly Asp Val Ser Glu Arg Val Arg Ile Leu Lys Asn Cys 
            740                 745                 750         


Gly Gln Lys Ser Leu Ala Tyr Leu Thr Ala Ala Thr His Gly Leu Asp 
        755                 760                 765             


Glu Glu Ala Glu Ser Leu Lys Glu Thr Phe Asp Pro Glu Lys Glu Thr 
    770                 775                 780                 


Ile Pro Asp Ile Asp Pro Asn Ala Lys Leu Leu Gln Pro Pro Ala Pro 
785                 790                 795                 800 


Ile Met Pro Leu Asp Thr Asn Trp Pro Leu Leu Thr Val Ser Lys Gly 
                805                 810                 815     


Phe Phe Glu Gly Thr Ile Ala Ser Lys Gly Lys Gly Gly Ala Leu Ala 
            820                 825                 830         


Ala Asp Ile Asp Ile Asp Thr Val Gly Thr Glu Gly Trp Gly Glu Asp 
        835                 840                 845             


Ala Glu Leu Gln Leu Asp Glu Asp Gly Phe Val Glu Ala Thr Glu Gly 
    850                 855                 860                 


Leu Gly Asp Asp Ala Leu Gly Lys Gly Gln Glu Glu Gly Gly Gly Trp 
865                 870                 875                 880 


Asp Val Glu Glu Asp Leu Glu Leu Pro Pro Glu Leu Asp Ile Ser Pro 
                885                 890                 895     


Gly Ala Ala Gly Gly Ala Glu Asp Gly Phe Phe Val Pro Pro Thr Lys 
            900                 905                 910         


Gly Thr Ser Pro Thr Gln Ile Trp Cys Asn Asn Ser Gln Leu Pro Val 
        915                 920                 925             


Asp His Ile Leu Ala Gly Ser Phe Glu Thr Ala Met Arg Leu Leu His 
    930                 935                 940                 


Asp Gln Val Gly Val Ile Gln Phe Gly Pro Tyr Lys Gln Leu Phe Leu 
945                 950                 955                 960 


Gln Thr Tyr Ala Arg Gly Arg Thr Thr Tyr Gln Ala Leu Pro Cys Leu 
                965                 970                 975     


Pro Ser Met Tyr Gly Tyr Pro Asn Arg Asn Trp Lys Asp Ala Gly Leu 
            980                 985                 990         


Lys Asn Gly Val Pro Ala Val Gly  Leu Lys Leu Asn Asp  Leu Ile Gln 
        995                 1000                 1005             


Arg Leu  Gln Leu Cys Tyr Gln  Leu Thr Thr Val Gly  Lys Phe Glu 
    1010                 1015                 1020             


Glu Ala  Val Glu Lys Phe Arg  Ser Ile Leu Leu Ser  Val Pro Leu 
    1025                 1030                 1035             


Leu Val  Val Asp Asn Lys Gln  Glu Ile Ala Glu Ala  Gln Gln Leu 
    1040                 1045                 1050             


Ile Thr  Ile Cys Arg Glu Tyr  Ile Val Gly Leu Ser  Val Glu Thr 
    1055                 1060                 1065             


Glu Arg  Lys Lys Leu Pro Lys  Glu Thr Leu Glu Gln  Gln Lys Arg 
    1070                 1075                 1080             


Ile Cys  Glu Met Ala Ala Tyr  Phe Thr His Ser Asn  Leu Gln Pro 
    1085                 1090                 1095             


Val His  Met Ile Leu Val Leu  Arg Thr Ala Leu Asn  Leu Phe Phe 
    1100                 1105                 1110             


Lys Leu  Lys Asn Phe Lys Thr  Ala Ala Thr Phe Ala  Arg Arg Leu 
    1115                 1120                 1125             


Leu Glu  Leu Gly Pro Lys Pro  Glu Val Ala Gln Gln  Thr Arg Lys 
    1130                 1135                 1140             


Ile Leu  Ser Ala Cys Glu Lys  Asn Pro Thr Asp Ala  Tyr Gln Leu 
    1145                 1150                 1155             


Asn Tyr  Asp Met His Asn Pro  Phe Asp Ile Cys Ala  Ala Ser Tyr 
    1160                 1165                 1170             


Arg Pro  Ile Tyr Arg Gly Lys  Pro Val Glu Lys Cys  Pro Leu Ser 
    1175                 1180                 1185             


Gly Ala  Cys Tyr Ser Pro Glu  Phe Lys Gly Gln Ile  Cys Arg Val 
    1190                 1195                 1200             


Thr Thr  Val Thr Glu Ile Gly  Lys Asp Val Ile Gly  Leu Arg Ile 
    1205                 1210                 1215             


Ser Pro  Leu Gln Phe Arg 
    1220                 


<210>  16
<211>  1224
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/NP_004362
<309>  2008-05-11
<313>  (1)..(1224)

<400>  16

Met Leu Thr Lys Phe Glu Thr Lys Ser Ala Arg Val Lys Gly Leu Ser 
1               5                   10                  15      


Phe His Pro Lys Arg Pro Trp Ile Leu Thr Ser Leu His Asn Gly Val 
            20                  25                  30          


Ile Gln Leu Trp Asp Tyr Arg Met Cys Thr Leu Ile Asp Lys Phe Asp 
        35                  40                  45              


Glu His Asp Gly Pro Val Arg Gly Ile Asp Phe His Lys Gln Gln Pro 
    50                  55                  60                  


Leu Phe Val Ser Gly Gly Asp Asp Tyr Lys Ile Lys Val Trp Asn Tyr 
65                  70                  75                  80  


Lys Leu Arg Arg Cys Leu Phe Thr Leu Leu Gly His Leu Asp Tyr Ile 
                85                  90                  95      


Arg Thr Thr Phe Phe His His Glu Tyr Pro Trp Ile Leu Ser Ala Ser 
            100                 105                 110         


Asp Asp Gln Thr Ile Arg Val Trp Asn Trp Gln Ser Arg Thr Cys Val 
        115                 120                 125             


Cys Val Leu Thr Gly His Asn His Tyr Val Met Cys Ala Gln Phe His 
    130                 135                 140                 


Pro Thr Glu Asp Leu Val Val Ser Ala Ser Leu Asp Gln Thr Val Arg 
145                 150                 155                 160 


Val Trp Asp Ile Ser Gly Leu Arg Lys Lys Asn Leu Ser Pro Gly Ala 
                165                 170                 175     


Val Glu Ser Asp Val Arg Gly Ile Thr Gly Val Asp Leu Phe Gly Thr 
            180                 185                 190         


Thr Asp Ala Val Val Lys His Val Leu Glu Gly His Asp Arg Gly Val 
        195                 200                 205             


Asn Trp Ala Ala Phe His Pro Thr Met Pro Leu Ile Val Ser Gly Ala 
    210                 215                 220                 


Asp Asp Arg Gln Val Lys Ile Trp Arg Met Asn Glu Ser Lys Ala Trp 
225                 230                 235                 240 


Glu Val Asp Thr Cys Arg Gly His Tyr Asn Asn Val Ser Cys Ala Val 
                245                 250                 255     


Phe His Pro Arg Gln Glu Leu Ile Leu Ser Asn Ser Glu Asp Lys Ser 
            260                 265                 270         


Ile Arg Val Trp Asp Met Ser Lys Arg Thr Gly Val Gln Thr Phe Arg 
        275                 280                 285             


Arg Asp His Asp Arg Phe Trp Val Leu Ala Ala His Pro Asn Leu Asn 
    290                 295                 300                 


Leu Phe Ala Ala Gly His Asp Gly Gly Met Ile Val Phe Lys Leu Glu 
305                 310                 315                 320 


Arg Glu Arg Pro Ala Tyr Ala Val His Gly Asn Met Leu His Tyr Val 
                325                 330                 335     


Lys Asp Arg Phe Leu Arg Gln Leu Asp Phe Asn Ser Ser Lys Asp Val 
            340                 345                 350         


Ala Val Met Gln Leu Arg Ser Gly Ser Lys Phe Pro Val Phe Asn Met 
        355                 360                 365             


Ser Tyr Asn Pro Ala Glu Asn Ala Val Leu Leu Cys Thr Arg Ala Ser 
    370                 375                 380                 


Asn Leu Glu Asn Ser Thr Tyr Asp Leu Tyr Thr Ile Pro Lys Asp Ala 
385                 390                 395                 400 


Asp Ser Gln Asn Pro Asp Ala Pro Glu Gly Lys Arg Ser Ser Gly Leu 
                405                 410                 415     


Thr Ala Val Trp Val Ala Arg Asn Arg Phe Ala Val Leu Asp Arg Met 
            420                 425                 430         


His Ser Leu Leu Ile Lys Asn Leu Lys Asn Glu Ile Thr Lys Lys Val 
        435                 440                 445             


Gln Val Pro Asn Cys Asp Glu Ile Phe Tyr Ala Gly Thr Gly Asn Leu 
    450                 455                 460                 


Leu Leu Arg Asp Ala Asp Ser Ile Thr Leu Phe Asp Val Gln Gln Lys 
465                 470                 475                 480 


Arg Thr Leu Ala Ser Val Lys Ile Ser Lys Val Lys Tyr Val Ile Trp 
                485                 490                 495     


Ser Ala Asp Met Ser His Val Ala Leu Leu Ala Lys His Ala Ile Val 
            500                 505                 510         


Ile Cys Asn Arg Lys Leu Asp Ala Leu Cys Asn Ile His Glu Asn Ile 
        515                 520                 525             


Arg Val Lys Ser Gly Ala Trp Asp Glu Ser Gly Val Phe Ile Tyr Thr 
    530                 535                 540                 


Thr Ser Asn His Ile Lys Tyr Ala Val Thr Thr Gly Asp His Gly Ile 
545                 550                 555                 560 


Ile Arg Thr Leu Asp Leu Pro Ile Tyr Val Thr Arg Val Lys Gly Asn 
                565                 570                 575     


Asn Val Tyr Cys Leu Asp Arg Glu Cys Arg Pro Arg Val Leu Thr Ile 
            580                 585                 590         


Asp Pro Thr Glu Phe Lys Phe Lys Leu Ala Leu Ile Asn Arg Lys Tyr 
        595                 600                 605             


Asp Glu Val Leu His Met Val Arg Asn Ala Lys Leu Val Gly Gln Ser 
    610                 615                 620                 


Ile Ile Ala Tyr Leu Gln Lys Lys Gly Tyr Pro Glu Val Ala Leu His 
625                 630                 635                 640 


Phe Val Lys Asp Glu Lys Thr Arg Phe Ser Leu Ala Leu Glu Cys Gly 
                645                 650                 655     


Asn Ile Glu Ile Ala Leu Glu Ala Ala Lys Ala Leu Asp Asp Lys Asn 
            660                 665                 670         


Cys Trp Glu Lys Leu Gly Glu Val Ala Leu Leu Gln Gly Asn His Gln 
        675                 680                 685             


Ile Val Glu Met Cys Tyr Gln Arg Thr Lys Asn Phe Asp Lys Leu Ser 
    690                 695                 700                 


Phe Leu Tyr Leu Ile Thr Gly Asn Leu Glu Lys Leu Arg Lys Met Met 
705                 710                 715                 720 


Lys Ile Ala Glu Ile Arg Lys Asp Met Ser Gly His Tyr Gln Asn Ala 
                725                 730                 735     


Leu Tyr Leu Gly Asp Val Ser Glu Arg Val Arg Ile Leu Lys Asn Cys 
            740                 745                 750         


Gly Gln Lys Ser Leu Ala Tyr Leu Thr Ala Ala Thr His Gly Leu Asp 
        755                 760                 765             


Glu Glu Ala Glu Ser Leu Lys Glu Thr Phe Asp Pro Glu Lys Glu Thr 
    770                 775                 780                 


Ile Pro Asp Ile Asp Pro Asn Ala Lys Leu Leu Gln Pro Pro Ala Pro 
785                 790                 795                 800 


Ile Met Pro Leu Asp Thr Asn Trp Pro Leu Leu Thr Val Ser Lys Gly 
                805                 810                 815     


Phe Phe Glu Gly Thr Ile Ala Ser Lys Gly Lys Gly Gly Ala Leu Ala 
            820                 825                 830         


Ala Asp Ile Asp Ile Asp Thr Val Gly Thr Glu Gly Trp Gly Glu Asp 
        835                 840                 845             


Ala Glu Leu Gln Leu Asp Glu Asp Gly Phe Val Glu Ala Thr Glu Gly 
    850                 855                 860                 


Leu Gly Asp Asp Ala Leu Gly Lys Gly Gln Glu Glu Gly Gly Gly Trp 
865                 870                 875                 880 


Asp Val Glu Glu Asp Leu Glu Leu Pro Pro Glu Leu Asp Ile Ser Pro 
                885                 890                 895     


Gly Ala Ala Gly Gly Ala Glu Asp Gly Phe Phe Val Pro Pro Thr Lys 
            900                 905                 910         


Gly Thr Ser Pro Thr Gln Ile Trp Cys Asn Asn Ser Gln Leu Pro Val 
        915                 920                 925             


Asp His Ile Leu Ala Gly Ser Phe Glu Thr Ala Met Arg Leu Leu His 
    930                 935                 940                 


Asp Gln Val Gly Val Ile Gln Phe Gly Pro Tyr Lys Gln Leu Phe Leu 
945                 950                 955                 960 


Gln Thr Tyr Ala Arg Gly Arg Thr Thr Tyr Gln Ala Leu Pro Cys Leu 
                965                 970                 975     


Pro Ser Met Tyr Gly Tyr Pro Asn Arg Asn Trp Lys Asp Ala Gly Leu 
            980                 985                 990         


Lys Asn Gly Val Pro Ala Val Gly  Leu Lys Leu Asn Asp  Leu Ile Gln 
        995                 1000                 1005             


Arg Leu  Gln Leu Cys Tyr Gln  Leu Thr Thr Val Gly  Lys Phe Glu 
    1010                 1015                 1020             


Glu Ala  Val Glu Lys Phe Arg  Ser Ile Leu Leu Ser  Val Pro Leu 
    1025                 1030                 1035             


Leu Val  Val Asp Asn Lys Gln  Glu Ile Ala Glu Ala  Gln Gln Leu 
    1040                 1045                 1050             


Ile Thr  Ile Cys Arg Glu Tyr  Ile Val Gly Leu Ser  Val Glu Thr 
    1055                 1060                 1065             


Glu Arg  Lys Lys Leu Pro Lys  Glu Thr Leu Glu Gln  Gln Lys Arg 
    1070                 1075                 1080             


Ile Cys  Glu Met Ala Ala Tyr  Phe Thr His Ser Asn  Leu Gln Pro 
    1085                 1090                 1095             


Val His  Met Ile Leu Val Leu  Arg Thr Ala Leu Asn  Leu Phe Phe 
    1100                 1105                 1110             


Lys Leu  Lys Asn Phe Lys Thr  Ala Ala Thr Phe Ala  Arg Arg Leu 
    1115                 1120                 1125             


Leu Glu  Leu Gly Pro Lys Pro  Glu Val Ala Gln Gln  Thr Arg Lys 
    1130                 1135                 1140             


Ile Leu  Ser Ala Cys Glu Lys  Asn Pro Thr Asp Ala  Tyr Gln Leu 
    1145                 1150                 1155             


Asn Tyr  Asp Met His Asn Pro  Phe Asp Ile Cys Ala  Ala Ser Tyr 
    1160                 1165                 1170             


Arg Pro  Ile Tyr Arg Gly Lys  Pro Val Glu Lys Cys  Pro Leu Ser 
    1175                 1180                 1185             


Gly Ala  Cys Tyr Ser Pro Glu  Phe Lys Gly Gln Ile  Cys Arg Val 
    1190                 1195                 1200             


Thr Thr  Val Thr Glu Ile Gly  Lys Asp Val Ile Gly  Leu Arg Ile 
    1205                 1210                 1215             


Ser Pro  Leu Gln Phe Arg 
    1220                 


<210>  17
<211>  1233
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/NP_001091868
<309>  2008-05-11
<313>  (1)..(1233)

<400>  17

Met Leu Thr Lys Phe Glu Thr Lys Ser Ala Arg Val Lys Gly Leu Ser 
1               5                   10                  15      


Phe His Pro Lys Arg Pro Trp Ile Leu Thr Ser Leu His Asn Gly Val 
            20                  25                  30          


Ile Gln Leu Trp Asp Tyr Arg Met Cys Thr Leu Ile Asp Lys Phe Asp 
        35                  40                  45              


Glu His Asp Gly Pro Val Arg Gly Ile Asp Phe His Lys Gln Gln Pro 
    50                  55                  60                  


Leu Phe Val Ser Gly Gly Asp Asp Tyr Lys Ile Lys Val Trp Asn Tyr 
65                  70                  75                  80  


Lys Leu Arg Arg Cys Leu Phe Thr Leu Leu Gly His Leu Asp Tyr Ile 
                85                  90                  95      


Arg Thr Thr Phe Phe His His Glu Tyr Pro Trp Ile Leu Ser Ala Ser 
            100                 105                 110         


Asp Asp Gln Thr Ile Arg Val Trp Asn Trp Gln Ser Arg Thr Cys Val 
        115                 120                 125             


Cys Val Leu Thr Gly His Asn His Tyr Val Met Cys Ala Gln Phe His 
    130                 135                 140                 


Pro Thr Glu Asp Leu Val Val Ser Ala Ser Leu Asp Gln Thr Val Arg 
145                 150                 155                 160 


Val Trp Asp Ile Ser Gly Leu Arg Lys Lys Asn Leu Ser Pro Gly Ala 
                165                 170                 175     


Val Glu Ser Asp Val Arg Gly Ile Thr Gly Val Asp Leu Phe Gly Thr 
            180                 185                 190         


Thr Asp Ala Val Val Lys His Val Leu Glu Gly His Asp Arg Gly Val 
        195                 200                 205             


Asn Trp Ala Ala Phe His Pro Thr Met Pro Leu Ile Val Ser Gly Ala 
    210                 215                 220                 


Asp Asp Arg Gln Val Lys Ile Trp Arg Met Asn Glu Ser Lys Ala Trp 
225                 230                 235                 240 


Glu Val Asp Thr Cys Arg Gly His Tyr Asn Asn Val Ser Cys Ala Val 
                245                 250                 255     


Phe His Pro Arg Gln Glu Leu Ile Leu Ser Asn Ser Glu Asp Lys Ser 
            260                 265                 270         


Ile Arg Val Trp Asp Met Ser Lys Arg Thr Gly Val Gln Thr Phe Arg 
        275                 280                 285             


Arg Asp His Asp Arg Phe Trp Val Leu Ala Ala His Pro Asn Leu Asn 
    290                 295                 300                 


Leu Phe Ala Ala Gly His Asp Gly Gly Met Ile Val Phe Lys Leu Glu 
305                 310                 315                 320 


Arg Glu Arg Pro Ala Tyr Ala Val His Gly Asn Met Leu His Tyr Val 
                325                 330                 335     


Lys Asp Arg Phe Leu Arg Gln Leu Asp Phe Asn Ser Ser Lys Asp Val 
            340                 345                 350         


Ala Val Met Gln Leu Arg Ser Gly Ser Lys Phe Pro Val Phe Asn Met 
        355                 360                 365             


Ser Tyr Asn Pro Ala Glu Asn Ala Val Leu Leu Cys Thr Arg Ala Ser 
    370                 375                 380                 


Asn Leu Glu Asn Ser Thr Tyr Asp Leu Tyr Thr Ile Pro Lys Asp Ala 
385                 390                 395                 400 


Asp Ser Gln Asn Pro Asp Ala Pro Glu Gly Lys Arg Ser Ser Gly Leu 
                405                 410                 415     


Thr Ala Val Trp Val Ala Arg Asn Arg Phe Ala Val Leu Asp Arg Met 
            420                 425                 430         


His Ser Leu Leu Ile Lys Asn Leu Lys Asn Glu Ile Thr Lys Lys Val 
        435                 440                 445             


Gln Val Pro Asn Cys Asp Glu Ile Phe Tyr Ala Gly Thr Gly Asn Leu 
    450                 455                 460                 


Leu Leu Arg Asp Ala Asp Ser Ile Thr Leu Phe Asp Val Gln Gln Lys 
465                 470                 475                 480 


Arg Thr Leu Ala Ser Val Lys Ile Ser Lys Val Lys Tyr Val Ile Trp 
                485                 490                 495     


Ser Ala Asp Met Ser His Val Ala Leu Leu Ala Lys His Glu His Ser 
            500                 505                 510         


Cys Pro Leu Pro Leu Thr Ala Ile Val Ile Cys Asn Arg Lys Leu Asp 
        515                 520                 525             


Ala Leu Cys Asn Ile His Glu Asn Ile Arg Val Lys Ser Gly Ala Trp 
    530                 535                 540                 


Asp Glu Ser Gly Val Phe Ile Tyr Thr Thr Ser Asn His Ile Lys Tyr 
545                 550                 555                 560 


Ala Val Thr Thr Gly Asp His Gly Ile Ile Arg Thr Leu Asp Leu Pro 
                565                 570                 575     


Ile Tyr Val Thr Arg Val Lys Gly Asn Asn Val Tyr Cys Leu Asp Arg 
            580                 585                 590         


Glu Cys Arg Pro Arg Val Leu Thr Ile Asp Pro Thr Glu Phe Lys Phe 
        595                 600                 605             


Lys Leu Ala Leu Ile Asn Arg Lys Tyr Asp Glu Val Leu His Met Val 
    610                 615                 620                 


Arg Asn Ala Lys Leu Val Gly Gln Ser Ile Ile Ala Tyr Leu Gln Lys 
625                 630                 635                 640 


Lys Gly Tyr Pro Glu Val Ala Leu His Phe Val Lys Asp Glu Lys Thr 
                645                 650                 655     


Arg Phe Ser Leu Ala Leu Glu Cys Gly Asn Ile Glu Ile Ala Leu Glu 
            660                 665                 670         


Ala Ala Lys Ala Leu Asp Asp Lys Asn Cys Trp Glu Lys Leu Gly Glu 
        675                 680                 685             


Val Ala Leu Leu Gln Gly Asn His Gln Ile Val Glu Met Cys Tyr Gln 
    690                 695                 700                 


Arg Thr Lys Asn Phe Asp Lys Leu Ser Phe Leu Tyr Leu Ile Thr Gly 
705                 710                 715                 720 


Asn Leu Glu Lys Leu Arg Lys Met Met Lys Ile Ala Glu Ile Arg Lys 
                725                 730                 735     


Asp Met Ser Gly His Tyr Gln Asn Ala Leu Tyr Leu Gly Asp Val Ser 
            740                 745                 750         


Glu Arg Val Arg Ile Leu Lys Asn Cys Gly Gln Lys Ser Leu Ala Tyr 
        755                 760                 765             


Leu Thr Ala Ala Thr His Gly Leu Asp Glu Glu Ala Glu Ser Leu Lys 
    770                 775                 780                 


Glu Thr Phe Asp Pro Glu Lys Glu Thr Ile Pro Asp Ile Asp Pro Asn 
785                 790                 795                 800 


Ala Lys Leu Leu Gln Pro Pro Ala Pro Ile Met Pro Leu Asp Thr Asn 
                805                 810                 815     


Trp Pro Leu Leu Thr Val Ser Lys Gly Phe Phe Glu Gly Thr Ile Ala 
            820                 825                 830         


Ser Lys Gly Lys Gly Gly Ala Leu Ala Ala Asp Ile Asp Ile Asp Thr 
        835                 840                 845             


Val Gly Thr Glu Gly Trp Gly Glu Asp Ala Glu Leu Gln Leu Asp Glu 
    850                 855                 860                 


Asp Gly Phe Val Glu Ala Thr Glu Gly Leu Gly Asp Asp Ala Leu Gly 
865                 870                 875                 880 


Lys Gly Gln Glu Glu Gly Gly Gly Trp Asp Val Glu Glu Asp Leu Glu 
                885                 890                 895     


Leu Pro Pro Glu Leu Asp Ile Ser Pro Gly Ala Ala Gly Gly Ala Glu 
            900                 905                 910         


Asp Gly Phe Phe Val Pro Pro Thr Lys Gly Thr Ser Pro Thr Gln Ile 
        915                 920                 925             


Trp Cys Asn Asn Ser Gln Leu Pro Val Asp His Ile Leu Ala Gly Ser 
    930                 935                 940                 


Phe Glu Thr Ala Met Arg Leu Leu His Asp Gln Val Gly Val Ile Gln 
945                 950                 955                 960 


Phe Gly Pro Tyr Lys Gln Leu Phe Leu Gln Thr Tyr Ala Arg Gly Arg 
                965                 970                 975     


Thr Thr Tyr Gln Ala Leu Pro Cys Leu Pro Ser Met Tyr Gly Tyr Pro 
            980                 985                 990         


Asn Arg Asn Trp Lys Asp Ala Gly  Leu Lys Asn Gly Val  Pro Ala Val 
        995                 1000                 1005             


Gly Leu  Lys Leu Asn Asp Leu  Ile Gln Arg Leu Gln  Leu Cys Tyr 
    1010                 1015                 1020             


Gln Leu  Thr Thr Val Gly Lys  Phe Glu Glu Ala Val  Glu Lys Phe 
    1025                 1030                 1035             


Arg Ser  Ile Leu Leu Ser Val  Pro Leu Leu Val Val  Asp Asn Lys 
    1040                 1045                 1050             


Gln Glu  Ile Ala Glu Ala Gln  Gln Leu Ile Thr Ile  Cys Arg Glu 
    1055                 1060                 1065             


Tyr Ile  Val Gly Leu Ser Val  Glu Thr Glu Arg Lys  Lys Leu Pro 
    1070                 1075                 1080             


Lys Glu  Thr Leu Glu Gln Gln  Lys Arg Ile Cys Glu  Met Ala Ala 
    1085                 1090                 1095             


Tyr Phe  Thr His Ser Asn Leu  Gln Pro Val His Met  Ile Leu Val 
    1100                 1105                 1110             


Leu Arg  Thr Ala Leu Asn Leu  Phe Phe Lys Leu Lys  Asn Phe Lys 
    1115                 1120                 1125             


Thr Ala  Ala Thr Phe Ala Arg  Arg Leu Leu Glu Leu  Gly Pro Lys 
    1130                 1135                 1140             


Pro Glu  Val Ala Gln Gln Thr  Arg Lys Ile Leu Ser  Ala Cys Glu 
    1145                 1150                 1155             


Lys Asn  Pro Thr Asp Ala Tyr  Gln Leu Asn Tyr Asp  Met His Asn 
    1160                 1165                 1170             


Pro Phe  Asp Ile Cys Ala Ala  Ser Tyr Arg Pro Ile  Tyr Arg Gly 
    1175                 1180                 1185             


Lys Pro  Val Glu Lys Cys Pro  Leu Ser Gly Ala Cys  Tyr Ser Pro 
    1190                 1195                 1200             


Glu Phe  Lys Gly Gln Ile Cys  Arg Val Thr Thr Val  Thr Glu Ile 
    1205                 1210                 1215             


Gly Lys  Asp Val Ile Gly Leu  Arg Ile Ser Pro Leu  Gln Phe Arg 
    1220                 1225                 1230             


<210>  18
<211>  953
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProtKB/P53618
<309>  2009-05-05
<313>  (1)..(953)

<400>  18

Met Thr Ala Ala Glu Asn Val Cys Tyr Thr Leu Ile Asn Val Pro Met 
1               5                   10                  15      


Asp Ser Glu Pro Pro Ser Glu Ile Ser Leu Lys Asn Asp Leu Glu Lys 
            20                  25                  30          


Gly Asp Val Lys Ser Lys Thr Glu Ala Leu Lys Lys Val Ile Ile Met 
        35                  40                  45              


Ile Leu Asn Gly Glu Lys Leu Pro Gly Leu Leu Met Thr Ile Ile Arg 
    50                  55                  60                  


Phe Val Leu Pro Leu Gln Asp His Thr Ile Lys Lys Leu Leu Leu Val 
65                  70                  75                  80  


Phe Trp Glu Ile Val Pro Lys Thr Thr Pro Asp Gly Arg Leu Leu His 
                85                  90                  95      


Glu Met Ile Leu Val Cys Asp Ala Tyr Arg Lys Asp Leu Gln His Pro 
            100                 105                 110         


Asn Glu Phe Ile Arg Gly Ser Thr Leu Arg Phe Leu Cys Lys Leu Lys 
        115                 120                 125             


Glu Ala Glu Leu Leu Glu Pro Leu Met Pro Ala Ile Arg Ala Cys Leu 
    130                 135                 140                 


Glu His Arg His Ser Tyr Val Arg Arg Asn Ala Val Leu Ala Ile Tyr 
145                 150                 155                 160 


Thr Ile Tyr Arg Asn Phe Glu His Leu Ile Pro Asp Ala Pro Glu Leu 
                165                 170                 175     


Ile His Asp Phe Leu Val Asn Glu Lys Asp Ala Ser Cys Lys Arg Asn 
            180                 185                 190         


Ala Phe Met Met Leu Ile His Ala Asp Gln Asp Arg Ala Leu Asp Tyr 
        195                 200                 205             


Leu Ser Thr Cys Ile Asp Gln Val Gln Thr Phe Gly Asp Ile Leu Gln 
    210                 215                 220                 


Leu Val Ile Val Glu Leu Ile Tyr Lys Val Cys His Ala Asn Pro Ser 
225                 230                 235                 240 


Glu Arg Ala Arg Phe Ile Arg Cys Ile Tyr Asn Leu Leu Gln Ser Ser 
                245                 250                 255     


Ser Pro Ala Val Lys Tyr Glu Ala Ala Gly Thr Leu Val Thr Leu Ser 
            260                 265                 270         


Ser Ala Pro Thr Ala Ile Lys Ala Ala Ala Gln Cys Tyr Ile Asp Leu 
        275                 280                 285             


Ile Ile Lys Glu Ser Asp Asn Asn Val Lys Leu Ile Val Leu Asp Arg 
    290                 295                 300                 


Leu Ile Glu Leu Lys Glu His Pro Ala His Glu Arg Val Leu Gln Asp 
305                 310                 315                 320 


Leu Val Met Asp Ile Leu Arg Val Leu Ser Thr Pro Asp Leu Glu Val 
                325                 330                 335     


Arg Lys Lys Thr Leu Gln Leu Ala Leu Asp Leu Val Ser Ser Arg Asn 
            340                 345                 350         


Val Glu Glu Leu Val Ile Val Leu Lys Lys Glu Val Ile Lys Thr Asn 
        355                 360                 365             


Asn Val Ser Glu His Glu Asp Thr Asp Lys Tyr Arg Gln Leu Leu Val 
    370                 375                 380                 


Arg Thr Leu His Ser Cys Ser Val Arg Phe Pro Asp Met Ala Ala Asn 
385                 390                 395                 400 


Val Ile Pro Val Leu Met Glu Phe Leu Ser Asp Asn Asn Glu Ala Ala 
                405                 410                 415     


Ala Ala Asp Val Leu Glu Phe Val Arg Glu Ala Ile Gln Arg Phe Asp 
            420                 425                 430         


Asn Leu Arg Met Leu Ile Val Glu Lys Met Leu Glu Val Phe His Ala 
        435                 440                 445             


Ile Lys Ser Val Lys Ile Tyr Arg Gly Ala Leu Trp Ile Leu Gly Glu 
    450                 455                 460                 


Tyr Cys Ser Thr Lys Glu Asp Ile Gln Ser Val Met Thr Glu Ile Arg 
465                 470                 475                 480 


Arg Ser Leu Gly Glu Ile Pro Ile Val Glu Ser Glu Ile Lys Lys Glu 
                485                 490                 495     


Ala Gly Glu Leu Lys Pro Glu Glu Glu Ile Thr Val Gly Pro Val Gln 
            500                 505                 510         


Lys Leu Val Thr Glu Met Gly Thr Tyr Ala Thr Gln Ser Ala Leu Ser 
        515                 520                 525             


Ser Ser Arg Pro Thr Lys Lys Glu Glu Asp Arg Pro Pro Leu Arg Gly 
    530                 535                 540                 


Phe Leu Leu Asp Gly Asp Phe Phe Val Ala Ala Ser Leu Ala Thr Thr 
545                 550                 555                 560 


Leu Thr Lys Ile Ala Leu Arg Tyr Val Ala Leu Val Gln Glu Lys Lys 
                565                 570                 575     


Lys Gln Asn Ser Phe Val Ala Glu Ala Met Leu Leu Met Ala Thr Ile 
            580                 585                 590         


Leu His Leu Gly Lys Ser Ser Leu Pro Lys Lys Pro Ile Thr Asp Asp 
        595                 600                 605             


Asp Val Asp Arg Ile Ser Leu Cys Leu Lys Val Leu Ser Glu Cys Ser 
    610                 615                 620                 


Pro Leu Met Asn Asp Ile Phe Asn Lys Glu Cys Arg Gln Ser Leu Ser 
625                 630                 635                 640 


His Met Leu Ser Ala Lys Leu Glu Glu Glu Lys Leu Ser Gln Lys Lys 
                645                 650                 655     


Glu Ser Glu Lys Arg Asn Val Thr Val Gln Pro Asp Asp Pro Ile Ser 
            660                 665                 670         


Phe Met Gln Leu Thr Ala Lys Asn Glu Met Asn Cys Lys Glu Asp Gln 
        675                 680                 685             


Phe Gln Leu Ser Leu Leu Ala Ala Met Gly Asn Thr Gln Arg Lys Glu 
    690                 695                 700                 


Ala Ala Asp Pro Leu Ala Ser Lys Leu Asn Lys Val Thr Gln Leu Thr 
705                 710                 715                 720 


Gly Phe Ser Asp Pro Val Tyr Ala Glu Ala Tyr Val His Val Asn Gln 
                725                 730                 735     


Tyr Asp Ile Val Leu Asp Val Leu Val Val Asn Gln Thr Ser Asp Thr 
            740                 745                 750         


Leu Gln Asn Cys Thr Leu Glu Leu Ala Thr Leu Gly Asp Leu Lys Leu 
        755                 760                 765             


Val Glu Lys Pro Ser Pro Leu Thr Leu Ala Pro His Asp Phe Ala Asn 
    770                 775                 780                 


Ile Lys Ala Asn Val Lys Val Ala Ser Thr Glu Asn Gly Ile Ile Phe 
785                 790                 795                 800 


Gly Asn Ile Val Tyr Asp Val Ser Gly Ala Ala Ser Asp Arg Asn Cys 
                805                 810                 815     


Val Val Leu Ser Asp Ile His Ile Asp Ile Met Asp Tyr Ile Gln Pro 
            820                 825                 830         


Ala Thr Cys Thr Asp Ala Glu Phe Arg Gln Met Trp Ala Glu Phe Glu 
        835                 840                 845             


Trp Glu Asn Lys Val Thr Val Asn Thr Asn Met Val Asp Leu Asn Asp 
    850                 855                 860                 


Tyr Leu Gln His Ile Leu Lys Ser Thr Asn Met Lys Cys Leu Thr Pro 
865                 870                 875                 880 


Glu Lys Ala Leu Ser Gly Tyr Cys Gly Phe Met Ala Ala Asn Leu Tyr 
                885                 890                 895     


Ala Arg Ser Ile Phe Gly Glu Asp Ala Leu Ala Asn Val Ser Ile Glu 
            900                 905                 910         


Lys Pro Ile His Gln Gly Pro Asp Ala Ala Val Thr Gly His Ile Arg 
        915                 920                 925             


Ile Arg Ala Lys Ser Gln Gly Met Ala Leu Ser Leu Gly Asp Lys Ile 
    930                 935                 940                 


Asn Leu Ser Gln Lys Lys Thr Ser Ile 
945                 950             


<210>  19
<211>  906
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProtKB/P35606
<309>  2009-05-05
<313>  (1)..(906)

<400>  19

Met Pro Leu Arg Leu Asp Ile Lys Arg Lys Leu Thr Ala Arg Ser Asp 
1               5                   10                  15      


Arg Val Lys Ser Val Asp Leu His Pro Thr Glu Pro Trp Met Leu Ala 
            20                  25                  30          


Ser Leu Tyr Asn Gly Ser Val Cys Val Trp Asn His Glu Thr Gln Thr 
        35                  40                  45              


Leu Val Lys Thr Phe Glu Val Cys Asp Leu Pro Val Arg Ala Ala Lys 
    50                  55                  60                  


Phe Val Ala Arg Lys Asn Trp Val Val Thr Gly Ala Asp Asp Met Gln 
65                  70                  75                  80  


Ile Arg Val Phe Asn Tyr Asn Thr Leu Glu Arg Val His Met Phe Glu 
                85                  90                  95      


Ala His Ser Asp Tyr Ile Arg Cys Ile Ala Val His Pro Thr Gln Pro 
            100                 105                 110         


Phe Ile Leu Thr Ser Ser Asp Asp Met Leu Ile Lys Leu Trp Asp Trp 
        115                 120                 125             


Asp Lys Lys Trp Ser Cys Ser Gln Val Phe Glu Gly His Thr His Tyr 
    130                 135                 140                 


Val Met Gln Ile Val Ile Asn Pro Lys Asp Asn Asn Gln Phe Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Asp Arg Thr Ile Lys Val Trp Gln Leu Gly Ser Ser Ser 
                165                 170                 175     


Pro Asn Phe Thr Leu Glu Gly His Glu Lys Gly Val Asn Cys Ile Asp 
            180                 185                 190         


Tyr Tyr Ser Gly Gly Asp Lys Pro Tyr Leu Ile Ser Gly Ala Asp Asp 
        195                 200                 205             


Arg Leu Val Lys Ile Trp Asp Tyr Gln Asn Lys Thr Cys Val Gln Thr 
    210                 215                 220                 


Leu Glu Gly His Ala Gln Asn Val Ser Cys Ala Ser Phe His Pro Glu 
225                 230                 235                 240 


Leu Pro Ile Ile Ile Thr Gly Ser Glu Asp Gly Thr Val Arg Ile Trp 
                245                 250                 255     


His Ser Ser Thr Tyr Arg Leu Glu Ser Thr Leu Asn Tyr Gly Met Glu 
            260                 265                 270         


Arg Val Trp Cys Val Ala Ser Leu Arg Gly Ser Asn Asn Val Ala Leu 
        275                 280                 285             


Gly Tyr Asp Glu Gly Ser Ile Ile Val Lys Leu Gly Arg Glu Glu Pro 
    290                 295                 300                 


Ala Met Ser Met Asp Ala Asn Gly Lys Ile Ile Trp Ala Lys His Ser 
305                 310                 315                 320 


Glu Val Gln Gln Ala Asn Leu Lys Ala Met Gly Asp Ala Glu Ile Lys 
                325                 330                 335     


Asp Gly Glu Arg Leu Pro Leu Ala Val Lys Asp Met Gly Ser Cys Glu 
            340                 345                 350         


Ile Tyr Pro Gln Thr Ile Gln His Asn Pro Asn Gly Arg Phe Val Val 
        355                 360                 365             


Val Cys Gly Asp Gly Glu Tyr Ile Ile Tyr Thr Ala Met Ala Leu Arg 
    370                 375                 380                 


Asn Lys Ser Phe Gly Ser Ala Gln Glu Phe Ala Trp Ala His Asp Ser 
385                 390                 395                 400 


Ser Glu Tyr Ala Ile Arg Glu Ser Asn Ser Ile Val Lys Ile Phe Lys 
                405                 410                 415     


Asn Phe Lys Glu Lys Lys Ser Phe Lys Pro Asp Phe Gly Ala Glu Ser 
            420                 425                 430         


Ile Tyr Gly Gly Phe Leu Leu Gly Val Arg Ser Val Asn Gly Leu Ala 
        435                 440                 445             


Phe Tyr Asp Trp Asp Asn Thr Glu Leu Ile Arg Arg Ile Glu Ile Gln 
    450                 455                 460                 


Pro Lys His Ile Phe Trp Ser Asp Ser Gly Glu Leu Val Cys Ile Ala 
465                 470                 475                 480 


Thr Glu Glu Ser Phe Phe Ile Leu Lys Tyr Leu Ser Glu Lys Val Leu 
                485                 490                 495     


Ala Ala Gln Glu Thr His Glu Gly Val Thr Glu Asp Gly Ile Glu Asp 
            500                 505                 510         


Ala Phe Glu Val Leu Gly Glu Ile Gln Glu Ile Val Lys Thr Gly Leu 
        515                 520                 525             


Trp Val Gly Asp Cys Phe Ile Tyr Thr Ser Ser Val Asn Arg Leu Asn 
    530                 535                 540                 


Tyr Tyr Val Gly Gly Glu Ile Val Thr Ile Ala His Leu Asp Arg Thr 
545                 550                 555                 560 


Met Tyr Leu Leu Gly Tyr Ile Pro Lys Asp Asn Arg Leu Tyr Leu Gly 
                565                 570                 575     


Asp Lys Glu Leu Asn Ile Ile Ser Tyr Ser Leu Leu Val Ser Val Leu 
            580                 585                 590         


Glu Tyr Gln Thr Ala Val Met Arg Arg Asp Phe Ser Met Ala Asp Lys 
        595                 600                 605             


Val Leu Pro Thr Ile Pro Lys Glu Gln Arg Thr Arg Val Ala His Phe 
    610                 615                 620                 


Leu Glu Lys Gln Gly Phe Lys Gln Gln Ala Leu Thr Val Ser Thr Asp 
625                 630                 635                 640 


Pro Glu His Arg Phe Glu Leu Ala Leu Gln Leu Gly Glu Leu Lys Ile 
                645                 650                 655     


Ala Tyr Gln Leu Ala Val Glu Ala Glu Ser Glu Gln Lys Trp Lys Gln 
            660                 665                 670         


Leu Ala Glu Leu Ala Ile Ser Lys Cys Gln Phe Gly Leu Ala Gln Glu 
        675                 680                 685             


Cys Leu His His Ala Gln Asp Tyr Gly Gly Leu Leu Leu Leu Ala Thr 
    690                 695                 700                 


Ala Ser Gly Asn Ala Asn Met Val Asn Lys Leu Ala Glu Gly Ala Glu 
705                 710                 715                 720 


Arg Asp Gly Lys Asn Asn Val Ala Phe Met Ser Tyr Phe Leu Gln Gly 
                725                 730                 735     


Lys Val Asp Ala Cys Leu Glu Leu Leu Ile Arg Thr Gly Arg Leu Pro 
            740                 745                 750         


Glu Ala Ala Phe Leu Ala Arg Thr Tyr Leu Pro Ser Gln Val Ser Arg 
        755                 760                 765             


Val Val Lys Leu Trp Arg Glu Asn Leu Ser Lys Val Asn Gln Lys Ala 
    770                 775                 780                 


Ala Glu Ser Leu Ala Asp Pro Thr Glu Tyr Glu Asn Leu Phe Pro Gly 
785                 790                 795                 800 


Leu Lys Glu Ala Phe Val Val Glu Glu Trp Val Lys Glu Thr His Ala 
                805                 810                 815     


Asp Leu Trp Pro Ala Lys Gln Tyr Pro Leu Val Thr Pro Asn Glu Glu 
            820                 825                 830         


Arg Asn Val Met Glu Glu Gly Lys Asp Phe Gln Pro Ser Arg Ser Thr 
        835                 840                 845             


Ala Gln Gln Glu Leu Asp Gly Lys Pro Ala Ser Pro Thr Pro Val Ile 
    850                 855                 860                 


Val Ala Ser His Thr Ala Asn Lys Glu Glu Lys Ser Leu Leu Glu Leu 
865                 870                 875                 880 


Glu Val Asp Leu Asp Asn Leu Glu Leu Glu Asp Ile Asp Thr Thr Asp 
                885                 890                 895     


Ile Asn Leu Asp Glu Asp Ile Leu Asp Asp 
            900                 905     


<210>  20
<211>  877
<212>  PRT
<213>  Homo sapiens

<300>
<308>   NCBI/EAW79040
<309>  2006-12-18
<313>  (1)..(877)

<400>  20

Met Leu Ala Ser Leu Tyr Asn Gly Ser Val Cys Val Trp Asn His Glu 
1               5                   10                  15      


Thr Gln Thr Leu Val Lys Thr Phe Glu Val Cys Asp Leu Pro Val Arg 
            20                  25                  30          


Ala Ala Lys Phe Val Ala Arg Lys Asn Trp Val Val Thr Gly Ala Asp 
        35                  40                  45              


Asp Met Gln Ile Arg Val Phe Asn Tyr Asn Thr Leu Glu Arg Val His 
    50                  55                  60                  


Met Phe Glu Ala His Ser Asp Tyr Ile Arg Cys Ile Ala Val His Pro 
65                  70                  75                  80  


Thr Gln Pro Phe Ile Leu Thr Ser Ser Asp Asp Met Leu Ile Lys Leu 
                85                  90                  95      


Trp Asp Trp Asp Lys Lys Trp Ser Cys Ser Gln Val Phe Glu Gly His 
            100                 105                 110         


Thr His Tyr Val Met Gln Ile Val Ile Asn Pro Lys Asp Asn Asn Gln 
        115                 120                 125             


Phe Ala Ser Ala Ser Leu Asp Arg Thr Ile Lys Val Trp Gln Leu Gly 
    130                 135                 140                 


Ser Ser Ser Pro Asn Phe Thr Leu Glu Gly His Glu Lys Gly Val Asn 
145                 150                 155                 160 


Cys Ile Asp Tyr Tyr Ser Gly Gly Asp Lys Pro Tyr Leu Ile Ser Gly 
                165                 170                 175     


Ala Asp Asp Arg Leu Val Lys Ile Trp Asp Tyr Gln Asn Lys Thr Cys 
            180                 185                 190         


Val Gln Thr Leu Glu Gly His Ala Gln Asn Val Ser Cys Ala Ser Phe 
        195                 200                 205             


His Pro Glu Leu Pro Ile Ile Ile Thr Gly Ser Glu Asp Gly Thr Val 
    210                 215                 220                 


Arg Ile Trp His Ser Ser Thr Tyr Arg Leu Glu Ser Thr Leu Asn Tyr 
225                 230                 235                 240 


Gly Met Glu Arg Val Trp Cys Val Ala Ser Leu Arg Gly Ser Asn Asn 
                245                 250                 255     


Val Ala Leu Gly Tyr Asp Glu Gly Ser Ile Ile Val Lys Leu Gly Arg 
            260                 265                 270         


Glu Glu Pro Ala Met Ser Met Asp Ala Asn Gly Lys Ile Ile Trp Ala 
        275                 280                 285             


Lys His Ser Glu Val Gln Gln Ala Asn Leu Lys Ala Met Gly Asp Ala 
    290                 295                 300                 


Glu Ile Lys Asp Gly Glu Arg Leu Pro Leu Ala Val Lys Asp Met Gly 
305                 310                 315                 320 


Ser Cys Glu Ile Tyr Pro Gln Thr Ile Gln His Asn Pro Asn Gly Arg 
                325                 330                 335     


Phe Val Val Val Cys Gly Asp Gly Glu Tyr Ile Ile Tyr Thr Ala Met 
            340                 345                 350         


Ala Leu Arg Asn Lys Ser Phe Gly Ser Ala Gln Glu Phe Ala Trp Ala 
        355                 360                 365             


His Asp Ser Ser Glu Tyr Ala Ile Arg Glu Ser Asn Ser Ile Val Lys 
    370                 375                 380                 


Ile Phe Lys Asn Phe Lys Glu Lys Lys Ser Phe Lys Pro Asp Phe Gly 
385                 390                 395                 400 


Ala Glu Ser Ile Tyr Gly Gly Phe Leu Leu Gly Val Arg Ser Val Asn 
                405                 410                 415     


Gly Leu Ala Phe Tyr Asp Trp Asp Asn Thr Glu Leu Ile Arg Arg Ile 
            420                 425                 430         


Glu Ile Gln Pro Lys His Ile Phe Trp Ser Asp Ser Gly Glu Leu Val 
        435                 440                 445             


Cys Ile Ala Thr Glu Glu Ser Phe Phe Ile Leu Lys Tyr Leu Ser Glu 
    450                 455                 460                 


Lys Val Leu Ala Ala Gln Glu Thr His Glu Gly Val Thr Glu Asp Gly 
465                 470                 475                 480 


Ile Glu Asp Ala Phe Glu Val Leu Gly Glu Ile Gln Glu Ile Val Lys 
                485                 490                 495     


Thr Gly Leu Trp Val Gly Asp Cys Phe Ile Tyr Thr Ser Ser Val Asn 
            500                 505                 510         


Arg Leu Asn Tyr Tyr Val Gly Gly Glu Ile Val Thr Ile Ala His Leu 
        515                 520                 525             


Asp Arg Thr Met Tyr Leu Leu Gly Tyr Ile Pro Lys Asp Asn Arg Leu 
    530                 535                 540                 


Tyr Leu Gly Asp Lys Glu Leu Asn Ile Ile Ser Tyr Ser Leu Leu Val 
545                 550                 555                 560 


Ser Val Leu Glu Tyr Gln Thr Ala Val Met Arg Arg Asp Phe Ser Met 
                565                 570                 575     


Ala Asp Lys Val Leu Pro Thr Ile Pro Lys Glu Gln Arg Thr Arg Val 
            580                 585                 590         


Ala His Phe Leu Glu Lys Gln Gly Phe Lys Gln Gln Ala Leu Thr Val 
        595                 600                 605             


Ser Thr Asp Pro Glu His Arg Phe Glu Leu Ala Leu Gln Leu Gly Glu 
    610                 615                 620                 


Leu Lys Ile Ala Tyr Gln Leu Ala Val Glu Ala Glu Ser Glu Gln Lys 
625                 630                 635                 640 


Trp Lys Gln Leu Ala Glu Leu Ala Ile Ser Lys Cys Gln Phe Gly Leu 
                645                 650                 655     


Ala Gln Glu Cys Leu His His Ala Gln Asp Tyr Gly Gly Leu Leu Leu 
            660                 665                 670         


Leu Ala Thr Ala Ser Gly Asn Ala Asn Met Val Asn Lys Leu Ala Glu 
        675                 680                 685             


Gly Ala Glu Arg Asp Gly Lys Asn Asn Val Ala Phe Met Ser Tyr Phe 
    690                 695                 700                 


Leu Gln Gly Lys Val Asp Ala Cys Leu Glu Leu Leu Ile Arg Thr Gly 
705                 710                 715                 720 


Arg Leu Pro Glu Ala Ala Phe Leu Ala Arg Thr Tyr Leu Pro Ser Gln 
                725                 730                 735     


Val Ser Arg Val Val Lys Leu Trp Arg Glu Asn Leu Ser Lys Val Asn 
            740                 745                 750         


Gln Lys Ala Ala Glu Ser Leu Ala Asp Pro Thr Glu Tyr Glu Asn Leu 
        755                 760                 765             


Phe Pro Gly Leu Lys Glu Ala Phe Val Val Glu Glu Trp Val Lys Glu 
    770                 775                 780                 


Thr His Ala Asp Leu Trp Pro Ala Lys Gln Tyr Pro Leu Val Thr Pro 
785                 790                 795                 800 


Asn Glu Glu Arg Asn Val Met Glu Glu Gly Lys Asp Phe Gln Pro Ser 
                805                 810                 815     


Arg Ser Thr Ala Gln Gln Glu Leu Asp Gly Lys Pro Ala Ser Pro Thr 
            820                 825                 830         


Pro Val Ile Val Ala Ser His Thr Ala Asn Lys Glu Glu Lys Ser Leu 
        835                 840                 845             


Leu Glu Leu Glu Val Asp Leu Asp Asn Leu Glu Leu Glu Asp Ile Asp 
    850                 855                 860                 


Thr Thr Asp Ile Asn Leu Asp Glu Asp Ile Leu Asp Asp 
865                 870                 875         


<210>  21
<211>  511
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProtKB/ P48444
<309>  2009-05-26
<313>  (1)..(511)

<400>  21

Met Val Leu Leu Ala Ala Ala Val Cys Thr Lys Ala Gly Lys Ala Ile 
1               5                   10                  15      


Val Ser Arg Gln Phe Val Glu Met Thr Arg Thr Arg Ile Glu Gly Leu 
            20                  25                  30          


Leu Ala Ala Phe Pro Lys Leu Met Asn Thr Gly Lys Gln His Thr Phe 
        35                  40                  45              


Val Glu Thr Glu Ser Val Arg Tyr Val Tyr Gln Pro Met Glu Lys Leu 
    50                  55                  60                  


Tyr Met Val Leu Ile Thr Thr Lys Asn Ser Asn Ile Leu Glu Asp Leu 
65                  70                  75                  80  


Glu Thr Leu Arg Leu Phe Ser Arg Val Ile Pro Glu Tyr Cys Arg Ala 
                85                  90                  95      


Leu Glu Glu Asn Glu Ile Ser Glu His Cys Phe Asp Leu Ile Phe Ala 
            100                 105                 110         


Phe Asp Glu Ile Val Ala Leu Gly Tyr Arg Glu Asn Val Asn Leu Ala 
        115                 120                 125             


Gln Ile Arg Thr Phe Thr Glu Met Asp Ser His Glu Glu Lys Val Phe 
    130                 135                 140                 


Arg Ala Val Arg Glu Thr Gln Glu Arg Glu Ala Lys Ala Glu Met Arg 
145                 150                 155                 160 


Arg Lys Ala Lys Glu Leu Gln Gln Ala Arg Arg Asp Ala Glu Arg Gln 
                165                 170                 175     


Gly Lys Lys Ala Pro Gly Phe Gly Gly Phe Gly Ser Ser Ala Val Ser 
            180                 185                 190         


Gly Gly Ser Thr Ala Ala Met Ile Thr Glu Thr Ile Ile Glu Thr Asp 
        195                 200                 205             


Lys Pro Lys Val Ala Pro Ala Pro Ala Arg Pro Ser Gly Pro Ser Lys 
    210                 215                 220                 


Ala Leu Lys Leu Gly Ala Lys Gly Lys Glu Val Asp Asn Phe Val Asp 
225                 230                 235                 240 


Lys Leu Lys Ser Glu Gly Glu Thr Ile Met Ser Ser Ser Met Gly Lys 
                245                 250                 255     


Arg Thr Ser Glu Ala Thr Lys Met His Ala Pro Pro Ile Asn Met Glu 
            260                 265                 270         


Ser Val His Met Lys Ile Glu Glu Lys Ile Thr Leu Thr Cys Gly Arg 
        275                 280                 285             


Asp Gly Gly Leu Gln Asn Met Glu Leu His Gly Met Ile Met Leu Arg 
    290                 295                 300                 


Ile Ser Asp Asp Lys Tyr Gly Arg Ile Arg Leu His Val Glu Asn Glu 
305                 310                 315                 320 


Asp Lys Lys Gly Val Gln Leu Gln Thr His Pro Asn Val Asp Lys Lys 
                325                 330                 335     


Leu Phe Thr Ala Glu Ser Leu Ile Gly Leu Lys Asn Pro Glu Lys Ser 
            340                 345                 350         


Phe Pro Val Asn Ser Asp Val Gly Val Leu Lys Trp Arg Leu Gln Thr 
        355                 360                 365             


Thr Glu Glu Ser Phe Ile Pro Leu Thr Ile Asn Cys Trp Pro Ser Glu 
    370                 375                 380                 


Ser Gly Asn Gly Cys Asp Val Asn Ile Glu Tyr Glu Leu Gln Glu Asp 
385                 390                 395                 400 


Asn Leu Glu Leu Asn Asp Val Val Ile Thr Ile Pro Leu Pro Ser Gly 
                405                 410                 415     


Val Gly Ala Pro Val Ile Gly Glu Ile Asp Gly Glu Tyr Arg His Asp 
            420                 425                 430         


Ser Arg Arg Asn Thr Leu Glu Trp Cys Leu Pro Val Ile Asp Ala Lys 
        435                 440                 445             


Asn Lys Ser Gly Ser Leu Glu Phe Ser Ile Ala Gly Gln Pro Asn Asp 
    450                 455                 460                 


Phe Phe Pro Val Gln Val Ser Phe Val Ser Lys Lys Asn Tyr Cys Asn 
465                 470                 475                 480 


Ile Gln Val Thr Lys Val Thr Gln Val Asp Gly Asn Ser Pro Val Arg 
                485                 490                 495     


Phe Ser Thr Glu Thr Thr Phe Leu Val Asp Lys Tyr Glu Ile Leu 
            500                 505                 510     


<210>  22
<211>  552
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/ACA05944
<309>  2008-02-20
<313>  (1)..(552)

<400>  22

Met Ala Glu Cys Asn Leu Val Ala Ile Leu Ile Ser Ser Ile Asp Asn 
1               5                   10                  15      


Pro Leu Asp Lys Asn Leu Asp Asn Gly Gly Asn Ser Cys Leu Asp Phe 
            20                  25                  30          


Arg Pro Leu Asn Ser Phe Ser Gln Pro Gln Val Leu Leu Ala Ala Ala 
        35                  40                  45              


Val Cys Thr Lys Ala Gly Lys Ala Ile Val Ser Arg Gln Phe Val Glu 
    50                  55                  60                  


Met Thr Arg Thr Arg Ile Glu Gly Leu Leu Ala Ala Phe Pro Lys Leu 
65                  70                  75                  80  


Met Asn Thr Gly Lys Gln His Thr Phe Val Glu Thr Glu Ser Val Arg 
                85                  90                  95      


Tyr Val Tyr Gln Pro Met Glu Lys Leu Tyr Met Val Leu Ile Thr Thr 
            100                 105                 110         


Lys Asn Ser Asn Ile Leu Glu Asp Leu Glu Thr Leu Arg Leu Phe Ser 
        115                 120                 125             


Arg Val Ile Pro Glu Tyr Cys Arg Ala Leu Glu Glu Asn Glu Ile Ser 
    130                 135                 140                 


Glu His Cys Phe Asp Leu Ile Phe Ala Phe Asp Glu Ile Val Ala Leu 
145                 150                 155                 160 


Gly Tyr Arg Glu Asn Val Asn Leu Ala Gln Ile Arg Thr Phe Thr Glu 
                165                 170                 175     


Met Asp Ser His Glu Glu Lys Val Phe Arg Ala Val Arg Glu Thr Gln 
            180                 185                 190         


Glu Arg Glu Ala Lys Ala Glu Met Arg Arg Lys Ala Lys Glu Leu Gln 
        195                 200                 205             


Gln Ala Arg Arg Asp Ala Glu Arg Gln Gly Lys Lys Ala Pro Gly Phe 
    210                 215                 220                 


Gly Gly Phe Gly Ser Ser Ala Val Ser Gly Gly Ser Thr Ala Ala Met 
225                 230                 235                 240 


Ile Thr Glu Thr Ile Ile Glu Thr Asp Lys Pro Lys Val Ala Pro Ala 
                245                 250                 255     


Pro Ala Arg Pro Ser Gly Pro Ser Lys Ala Leu Lys Leu Gly Ala Lys 
            260                 265                 270         


Gly Lys Glu Val Asp Asn Phe Val Asp Lys Leu Lys Ser Glu Gly Glu 
        275                 280                 285             


Thr Ile Met Ser Ser Ser Met Gly Lys Arg Thr Ser Glu Ala Thr Lys 
    290                 295                 300                 


Met His Ala Pro Pro Ile Asn Met Glu Ser Val His Met Lys Ile Glu 
305                 310                 315                 320 


Glu Lys Ile Thr Leu Thr Cys Gly Arg Asp Gly Gly Leu Gln Asn Met 
                325                 330                 335     


Glu Leu His Gly Met Ile Met Leu Arg Ile Ser Asp Asp Lys Tyr Gly 
            340                 345                 350         


Arg Ile Arg Leu His Val Glu Asn Glu Asp Lys Lys Gly Val Gln Leu 
        355                 360                 365             


Gln Thr His Pro Asn Val Asp Lys Lys Leu Phe Thr Ala Glu Ser Leu 
    370                 375                 380                 


Ile Gly Leu Lys Asn Pro Glu Lys Ser Phe Pro Val Asn Ser Asp Val 
385                 390                 395                 400 


Gly Val Leu Lys Trp Arg Leu Gln Thr Thr Glu Glu Ser Phe Ile Pro 
                405                 410                 415     


Leu Thr Ile Asn Cys Trp Pro Ser Glu Ser Gly Asn Gly Cys Asp Val 
            420                 425                 430         


Asn Ile Glu Tyr Glu Leu Gln Glu Asp Asn Leu Glu Leu Asn Asp Val 
        435                 440                 445             


Val Ile Thr Ile Pro Leu Pro Ser Gly Val Gly Ala Pro Val Ile Gly 
    450                 455                 460                 


Glu Ile Asp Gly Glu Tyr Arg His Asp Ser Arg Arg Asn Thr Leu Glu 
465                 470                 475                 480 


Trp Cys Leu Pro Val Ile Asp Ala Lys Asn Lys Ser Gly Ser Leu Glu 
                485                 490                 495     


Phe Ser Ile Ala Gly Gln Pro Asn Asp Phe Phe Pro Val Gln Val Ser 
            500                 505                 510         


Phe Val Ser Lys Lys Asn Tyr Cys Asn Ile Gln Val Thr Lys Val Thr 
        515                 520                 525             


Gln Val Asp Gly Asn Ser Pro Val Arg Phe Ser Thr Glu Thr Thr Phe 
    530                 535                 540                 


Leu Val Asp Lys Tyr Glu Ile Leu 
545                 550         


<210>  23
<211>  308
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProtKB/O14579
<309>  2009-05-05
<313>  (1)..(308)

<400>  23

Met Ala Pro Pro Ala Pro Gly Pro Ala Ser Gly Gly Ser Gly Glu Val 
1               5                   10                  15      


Asp Glu Leu Phe Asp Val Lys Asn Ala Phe Tyr Ile Gly Ser Tyr Gln 
            20                  25                  30          


Gln Cys Ile Asn Glu Ala Gln Arg Val Lys Leu Ser Ser Pro Glu Arg 
        35                  40                  45              


Asp Val Glu Arg Asp Val Phe Leu Tyr Arg Ala Tyr Leu Ala Gln Arg 
    50                  55                  60                  


Lys Phe Gly Val Val Leu Asp Glu Ile Lys Pro Ser Ser Ala Pro Glu 
65                  70                  75                  80  


Leu Gln Ala Val Arg Met Phe Ala Asp Tyr Leu Ala His Glu Ser Arg 
                85                  90                  95      


Arg Asp Ser Ile Val Ala Glu Leu Asp Arg Glu Met Ser Arg Ser Val 
            100                 105                 110         


Asp Val Thr Asn Thr Thr Phe Leu Leu Met Ala Ala Ser Ile Tyr Leu 
        115                 120                 125             


His Asp Gln Asn Pro Asp Ala Ala Leu Arg Ala Leu His Gln Gly Asp 
    130                 135                 140                 


Ser Leu Glu Cys Thr Ala Met Thr Val Gln Ile Leu Leu Lys Leu Asp 
145                 150                 155                 160 


Arg Leu Asp Leu Ala Arg Lys Glu Leu Lys Arg Met Gln Asp Leu Asp 
                165                 170                 175     


Glu Asp Ala Thr Leu Thr Gln Leu Ala Thr Ala Trp Val Ser Leu Ala 
            180                 185                 190         


Thr Gly Gly Glu Lys Leu Gln Asp Ala Tyr Tyr Ile Phe Gln Glu Met 
        195                 200                 205             


Ala Asp Lys Cys Ser Pro Thr Leu Leu Leu Leu Asn Gly Gln Ala Ala 
    210                 215                 220                 


Cys His Met Ala Gln Gly Arg Trp Glu Ala Ala Glu Gly Leu Leu Gln 
225                 230                 235                 240 


Glu Ala Leu Asp Lys Asp Ser Gly Tyr Pro Glu Thr Leu Val Asn Leu 
                245                 250                 255     


Ile Val Leu Ser Gln His Leu Gly Lys Pro Pro Glu Val Thr Asn Arg 
            260                 265                 270         


Tyr Leu Ser Gln Leu Lys Asp Ala His Arg Ser His Pro Phe Ile Lys 
        275                 280                 285             


Glu Tyr Gln Ala Lys Glu Asn Asp Phe Asp Arg Leu Val Leu Gln Tyr 
    290                 295                 300                 


Ala Pro Ser Ala 
305             


<210>  24
<211>  256
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/NP_955476
<309>  2008-09-28
<313>  (1)..(256)

<400>  24

Met Ala Pro Pro Ala Pro Gly Pro Ala Ser Gly Gly Ser Gly Glu Val 
1               5                   10                  15      


Asp Glu Leu Phe Asp Val Lys Asn Ala Phe Tyr Ile Gly Ser Tyr Gln 
            20                  25                  30          


Gln Cys Ile Asn Glu Ala Gln Arg Val Lys Leu Ser Ser Pro Glu Arg 
        35                  40                  45              


Asp Val Glu Arg Asp Val Phe Leu Tyr Arg Ala Tyr Leu Ala Gln Arg 
    50                  55                  60                  


Lys Phe Gly Val Val Leu Asp Glu Ile Lys Pro Ser Ser Ala Pro Glu 
65                  70                  75                  80  


Leu Gln Ala Val Arg Met Phe Ala Asp Tyr Leu Ala His Glu Ser Arg 
                85                  90                  95      


Arg Asp Ser Ile Val Ala Glu Leu Asp Arg Glu Met Ser Arg Ser Val 
            100                 105                 110         


Asp Val Thr Asn Thr Thr Phe Leu Leu Met Ala Ala Ser Ile Tyr Leu 
        115                 120                 125             


His Asp Gln Asn Pro Asp Ala Ala Leu Arg Ala Leu His Gln Gly Asp 
    130                 135                 140                 


Ser Leu Glu Cys Thr Ala Met Thr Val Gln Ile Leu Leu Lys Leu Asp 
145                 150                 155                 160 


Arg Leu Asp Leu Ala Arg Lys Glu Leu Lys Arg Met Gln Asp Leu Asp 
                165                 170                 175     


Glu Asp Ala Thr Leu Thr Gln Leu Ala Thr Ala Trp Val Ser Leu Ala 
            180                 185                 190         


Thr Asp Ser Gly Tyr Pro Glu Thr Leu Val Asn Leu Ile Val Leu Ser 
        195                 200                 205             


Gln His Leu Gly Lys Pro Pro Glu Val Thr Asn Arg Tyr Leu Ser Gln 
    210                 215                 220                 


Leu Lys Asp Ala His Arg Ser His Pro Phe Ile Lys Glu Tyr Gln Ala 
225                 230                 235                 240 


Lys Glu Asn Asp Phe Asp Arg Leu Val Leu Gln Tyr Ala Pro Ser Ala 
                245                 250                 255     


<210>  25
<211>  257
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/NP_955474
<309>  2008-09-28
<313>  (1)..(257)

<400>  25

Met Ala Pro Pro Ala Pro Gly Pro Ala Ser Gly Gly Ser Gly Glu Val 
1               5                   10                  15      


Asp Glu Leu Phe Asp Val Lys Asn Ala Phe Tyr Ile Gly Ser Tyr Gln 
            20                  25                  30          


Gln Cys Ile Asn Glu Ala Gln Arg Val Lys Leu Ser Ser Pro Glu Arg 
        35                  40                  45              


Asp Val Glu Arg Asp Val Phe Leu Tyr Arg Ala Tyr Leu Ala Gln Arg 
    50                  55                  60                  


Lys Phe Gly Val Val Leu Asp Glu Ile Lys Pro Ser Ser Ala Pro Glu 
65                  70                  75                  80  


Leu Gln Ala Val Arg Met Phe Ala Asp Tyr Leu Ala His Glu Ser Arg 
                85                  90                  95      


Ser Thr Ala Met Thr Val Gln Ile Leu Leu Lys Leu Asp Arg Leu Asp 
            100                 105                 110         


Leu Ala Arg Lys Glu Leu Lys Arg Met Gln Asp Leu Asp Glu Asp Ala 
        115                 120                 125             


Thr Leu Thr Gln Leu Ala Thr Ala Trp Val Ser Leu Ala Thr Gly Gly 
    130                 135                 140                 


Glu Lys Leu Gln Asp Ala Tyr Tyr Ile Phe Gln Glu Met Ala Asp Lys 
145                 150                 155                 160 


Cys Ser Pro Thr Leu Leu Leu Leu Asn Gly Gln Ala Ala Cys His Met 
                165                 170                 175     


Ala Gln Gly Arg Trp Glu Ala Ala Glu Gly Leu Leu Gln Glu Ala Leu 
            180                 185                 190         


Asp Lys Asp Ser Gly Tyr Pro Glu Thr Leu Val Asn Leu Ile Val Leu 
        195                 200                 205             


Ser Gln His Leu Gly Lys Pro Pro Glu Val Thr Asn Arg Tyr Leu Ser 
    210                 215                 220                 


Gln Leu Lys Asp Ala His Arg Ser His Pro Phe Ile Lys Glu Tyr Gln 
225                 230                 235                 240 


Ala Lys Glu Asn Asp Phe Asp Arg Leu Val Leu Gln Tyr Ala Pro Ser 
                245                 250                 255     


Ala 
    


<210>  26
<211>  874
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProtKB/ Q9Y678
<309>  2009-04-14
<313>  (1)..(874)

<400>  26

Met Leu Lys Lys Phe Asp Lys Lys Asp Glu Glu Ser Gly Gly Gly Ser 
1               5                   10                  15      


Asn Pro Phe Gln His Leu Glu Lys Ser Ala Val Leu Gln Glu Ala Arg 
            20                  25                  30          


Val Phe Asn Glu Thr Pro Ile Asn Pro Arg Lys Cys Ala His Ile Leu 
        35                  40                  45              


Thr Lys Ile Leu Tyr Leu Ile Asn Gln Gly Glu His Leu Gly Thr Thr 
    50                  55                  60                  


Glu Ala Thr Glu Ala Phe Phe Ala Met Thr Lys Leu Phe Gln Ser Asn 
65                  70                  75                  80  


Asp Pro Thr Leu Arg Arg Met Cys Tyr Leu Thr Ile Lys Glu Met Ser 
                85                  90                  95      


Cys Ile Ala Glu Asp Val Ile Ile Val Thr Ser Ser Leu Thr Lys Asp 
            100                 105                 110         


Met Thr Gly Lys Glu Asp Asn Tyr Arg Gly Pro Ala Val Arg Ala Leu 
        115                 120                 125             


Cys Gln Ile Thr Asp Ser Thr Met Leu Gln Ala Ile Glu Arg Tyr Met 
    130                 135                 140                 


Lys Gln Ala Ile Val Asp Lys Val Pro Ser Val Ser Ser Ser Ala Leu 
145                 150                 155                 160 


Val Ser Ser Leu His Leu Leu Lys Cys Ser Phe Asp Val Val Lys Arg 
                165                 170                 175     


Trp Val Asn Glu Ala Gln Glu Ala Ala Ser Ser Asp Asn Ile Met Val 
            180                 185                 190         


Gln Tyr His Ala Leu Gly Leu Leu Tyr His Val Arg Lys Asn Asp Arg 
        195                 200                 205             


Leu Ala Val Asn Lys Met Ile Ser Lys Val Thr Arg His Gly Leu Lys 
    210                 215                 220                 


Ser Pro Phe Ala Tyr Cys Met Met Ile Arg Val Ala Ser Lys Gln Leu 
225                 230                 235                 240 


Glu Glu Glu Asp Gly Ser Arg Asp Ser Pro Leu Phe Asp Phe Ile Glu 
                245                 250                 255     


Ser Cys Leu Arg Asn Lys His Glu Met Val Val Tyr Glu Ala Ala Ser 
            260                 265                 270         


Ala Ile Val Asn Leu Pro Gly Cys Ser Ala Lys Glu Leu Ala Pro Ala 
        275                 280                 285             


Val Ser Val Leu Gln Leu Phe Cys Ser Ser Pro Lys Ala Ala Leu Arg 
    290                 295                 300                 


Tyr Ala Ala Val Arg Thr Leu Asn Lys Val Ala Met Lys His Pro Ser 
305                 310                 315                 320 


Ala Val Thr Ala Cys Asn Leu Asp Leu Glu Asn Leu Val Thr Asp Ser 
                325                 330                 335     


Asn Arg Ser Ile Ala Thr Leu Ala Ile Thr Thr Leu Leu Lys Thr Gly 
            340                 345                 350         


Ser Glu Ser Ser Ile Asp Arg Leu Met Lys Gln Ile Ser Ser Phe Met 
        355                 360                 365             


Ser Glu Ile Ser Asp Glu Phe Lys Val Val Val Val Gln Ala Ile Ser 
    370                 375                 380                 


Ala Leu Cys Gln Lys Tyr Pro Arg Lys His Ala Val Leu Met Asn Phe 
385                 390                 395                 400 


Leu Phe Thr Met Leu Arg Glu Glu Gly Gly Phe Glu Tyr Lys Arg Ala 
                405                 410                 415     


Ile Val Asp Cys Ile Ile Ser Ile Ile Glu Glu Asn Ser Glu Ser Lys 
            420                 425                 430         


Glu Thr Gly Leu Ser His Leu Cys Glu Phe Ile Glu Asp Cys Glu Phe 
        435                 440                 445             


Thr Val Leu Ala Thr Arg Ile Leu His Leu Leu Gly Gln Glu Gly Pro 
    450                 455                 460                 


Lys Thr Thr Asn Pro Ser Lys Tyr Ile Arg Phe Ile Tyr Asn Arg Val 
465                 470                 475                 480 


Val Leu Glu His Glu Glu Val Arg Ala Gly Ala Val Ser Ala Leu Ala 
                485                 490                 495     


Lys Phe Gly Ala Gln Asn Glu Glu Met Leu Pro Ser Ile Leu Val Leu 
            500                 505                 510         


Leu Lys Arg Cys Val Met Asp Asp Asp Asn Glu Val Arg Asp Arg Ala 
        515                 520                 525             


Thr Phe Tyr Leu Asn Val Leu Glu Gln Lys Gln Lys Ala Leu Asn Ala 
    530                 535                 540                 


Gly Tyr Ile Leu Asn Gly Leu Thr Val Ser Ile Pro Gly Leu Glu Arg 
545                 550                 555                 560 


Ala Leu Gln Gln Tyr Thr Leu Glu Pro Ser Glu Lys Pro Phe Asp Leu 
                565                 570                 575     


Lys Ser Val Pro Leu Ala Thr Ala Pro Met Ala Glu Gln Arg Thr Glu 
            580                 585                 590         


Ser Thr Pro Ile Thr Ala Val Lys Gln Pro Glu Lys Val Ala Ala Thr 
        595                 600                 605             


Arg Gln Glu Ile Phe Gln Glu Gln Leu Ala Ala Val Pro Glu Phe Arg 
    610                 615                 620                 


Gly Leu Gly Pro Leu Phe Lys Ser Ser Pro Glu Pro Val Ala Leu Thr 
625                 630                 635                 640 


Glu Ser Glu Thr Glu Tyr Val Ile Arg Cys Thr Lys His Thr Phe Thr 
                645                 650                 655     


Asn His Met Val Phe Gln Phe Asp Cys Thr Asn Thr Leu Asn Asp Gln 
            660                 665                 670         


Thr Leu Glu Asn Val Thr Val Gln Met Glu Pro Thr Glu Ala Tyr Glu 
        675                 680                 685             


Val Leu Cys Tyr Val Pro Ala Arg Ser Leu Pro Tyr Asn Gln Pro Gly 
    690                 695                 700                 


Thr Cys Tyr Thr Leu Val Ala Leu Pro Lys Glu Asp Pro Thr Ala Val 
705                 710                 715                 720 


Ala Cys Thr Phe Ser Cys Met Met Lys Phe Thr Val Lys Asp Cys Asp 
                725                 730                 735     


Pro Thr Thr Gly Glu Thr Asp Asp Glu Gly Tyr Glu Asp Glu Tyr Val 
            740                 745                 750         


Leu Glu Asp Leu Glu Val Thr Val Ala Asp His Ile Gln Lys Val Met 
        755                 760                 765             


Lys Leu Asn Phe Glu Ala Ala Trp Asp Glu Val Gly Asp Glu Phe Glu 
    770                 775                 780                 


Lys Glu Glu Thr Phe Thr Leu Ser Thr Ile Lys Thr Leu Glu Glu Ala 
785                 790                 795                 800 


Val Gly Asn Ile Val Lys Phe Leu Gly Met His Pro Cys Glu Arg Ser 
                805                 810                 815     


Asp Lys Val Pro Asp Asn Lys Asn Thr His Thr Leu Leu Leu Ala Gly 
            820                 825                 830         


Val Phe Arg Gly Gly His Asp Ile Leu Val Arg Ser Arg Leu Leu Leu 
        835                 840                 845             


Leu Asp Thr Val Thr Met Gln Val Thr Ala Arg Ser Leu Glu Glu Leu 
    850                 855                 860                 


Pro Val Asp Ile Ile Leu Ala Ser Val Gly 
865                 870                 


<210>  27
<211>  871
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/NP_036265
<309>  2008-08-20
<313>  (1)..(871)

<400>  27

Met Ile Lys Lys Phe Asp Lys Lys Asp Glu Glu Ser Gly Ser Gly Ser 
1               5                   10                  15      


Asn Pro Phe Gln His Leu Glu Lys Ser Ala Val Leu Gln Glu Ala Arg 
            20                  25                  30          


Ile Phe Asn Glu Thr Pro Ile Asn Pro Arg Arg Cys Leu His Ile Leu 
        35                  40                  45              


Thr Lys Ile Leu Tyr Leu Leu Asn Gln Gly Glu His Phe Gly Thr Thr 
    50                  55                  60                  


Glu Ala Thr Glu Ala Phe Phe Ala Met Thr Arg Leu Phe Gln Ser Asn 
65                  70                  75                  80  


Asp Gln Thr Leu Arg Arg Met Cys Tyr Leu Thr Ile Lys Glu Met Ala 
                85                  90                  95      


Thr Ile Ser Glu Asp Val Ile Ile Val Thr Ser Ser Leu Thr Lys Asp 
            100                 105                 110         


Met Thr Gly Lys Glu Asp Val Tyr Arg Gly Pro Ala Ile Arg Ala Leu 
        115                 120                 125             


Cys Arg Ile Thr Asp Gly Thr Met Leu Gln Ala Ile Glu Arg Tyr Met 
    130                 135                 140                 


Lys Gln Ala Ile Val Asp Lys Val Ser Ser Val Ser Ser Ser Ala Leu 
145                 150                 155                 160 


Val Ser Ser Leu His Met Met Lys Ile Ser Tyr Asp Val Val Lys Arg 
                165                 170                 175     


Trp Ile Asn Glu Ala Gln Glu Ala Ala Ser Ser Asp Asn Ile Met Val 
            180                 185                 190         


Gln Tyr His Ala Leu Gly Val Leu Tyr His Leu Arg Lys Asn Asp Arg 
        195                 200                 205             


Leu Ala Val Ser Lys Met Leu Asn Lys Phe Thr Lys Ser Gly Leu Lys 
    210                 215                 220                 


Ser Gln Phe Ala Tyr Cys Met Leu Ile Arg Ile Ala Ser Arg Leu Leu 
225                 230                 235                 240 


Lys Glu Thr Glu Asp Gly His Glu Ser Pro Leu Phe Asp Phe Ile Glu 
                245                 250                 255     


Ser Cys Leu Arg Asn Lys His Glu Met Val Ile Tyr Glu Ala Ala Ser 
            260                 265                 270         


Ala Ile Ile His Leu Pro Asn Cys Thr Ala Arg Glu Leu Ala Pro Ala 
        275                 280                 285             


Val Ser Val Leu Gln Leu Phe Cys Ser Ser Pro Lys Pro Ala Leu Arg 
    290                 295                 300                 


Tyr Ala Ala Val Arg Thr Leu Asn Lys Val Ala Met Lys His Pro Ser 
305                 310                 315                 320 


Ala Val Thr Ala Cys Asn Leu Asp Leu Glu Asn Leu Ile Thr Asp Ser 
                325                 330                 335     


Asn Arg Ser Ile Ala Thr Leu Ala Ile Thr Thr Leu Leu Lys Thr Gly 
            340                 345                 350         


Ser Glu Ser Ser Val Asp Arg Leu Met Lys Gln Ile Ser Ser Phe Val 
        355                 360                 365             


Ser Glu Ile Ser Asp Glu Phe Lys Val Val Val Val Gln Ala Ile Ser 
    370                 375                 380                 


Ala Leu Cys Gln Lys Tyr Pro Arg Lys His Ser Val Met Met Thr Phe 
385                 390                 395                 400 


Leu Ser Asn Met Leu Arg Asp Asp Gly Gly Phe Glu Tyr Lys Arg Ala 
                405                 410                 415     


Ile Val Asp Cys Ile Ile Ser Ile Val Glu Glu Asn Pro Glu Ser Lys 
            420                 425                 430         


Glu Ala Gly Leu Ala His Leu Cys Glu Phe Ile Glu Asp Cys Glu His 
        435                 440                 445             


Thr Val Leu Ala Thr Lys Ile Leu His Leu Leu Gly Lys Glu Gly Pro 
    450                 455                 460                 


Arg Thr Pro Val Pro Ser Lys Tyr Ile Arg Phe Ile Phe Asn Arg Val 
465                 470                 475                 480 


Val Leu Glu Asn Glu Ala Val Arg Ala Ala Ala Val Ser Ala Leu Ala 
                485                 490                 495     


Lys Phe Gly Ala Gln Asn Glu Ser Leu Leu Pro Ser Ile Leu Val Leu 
            500                 505                 510         


Leu Gln Arg Cys Met Met Asp Thr Asp Asp Glu Val Arg Asp Arg Ala 
        515                 520                 525             


Thr Phe Tyr Leu Asn Val Leu Gln Gln Arg Gln Met Ala Leu Asn Ala 
    530                 535                 540                 


Thr Tyr Ile Phe Asn Gly Leu Thr Val Ser Val Pro Gly Met Glu Lys 
545                 550                 555                 560 


Ala Leu His Gln Tyr Thr Leu Glu Pro Ser Glu Lys Pro Phe Asp Met 
                565                 570                 575     


Lys Ser Ile Pro Leu Ala Met Ala Pro Val Phe Glu Gln Lys Ala Glu 
            580                 585                 590         


Ile Thr Leu Val Ala Thr Lys Pro Glu Lys Leu Ala Pro Ser Arg Gln 
        595                 600                 605             


Asp Ile Phe Gln Glu Gln Leu Ala Ala Ile Pro Glu Phe Leu Asn Ile 
    610                 615                 620                 


Gly Pro Leu Phe Lys Ser Ser Glu Pro Val Gln Leu Thr Glu Ala Glu 
625                 630                 635                 640 


Thr Glu Tyr Phe Val Arg Cys Ile Lys His Met Phe Thr Asn His Ile 
                645                 650                 655     


Val Phe Gln Phe Asp Cys Thr Asn Thr Leu Asn Asp Gln Leu Leu Glu 
            660                 665                 670         


Lys Val Thr Val Gln Met Glu Pro Ser Asp Ser Tyr Glu Val Leu Ser 
        675                 680                 685             


Cys Ile Pro Ala Pro Ser Leu Pro Tyr Asn Gln Pro Gly Ile Cys Tyr 
    690                 695                 700                 


Thr Leu Val Arg Leu Pro Asp Asp Asp Pro Thr Ala Val Ala Gly Ser 
705                 710                 715                 720 


Phe Ser Cys Thr Met Lys Phe Thr Val Arg Asp Cys Asp Pro Asn Thr 
                725                 730                 735     


Gly Val Pro Asp Glu Asp Gly Tyr Asp Asp Glu Tyr Val Leu Glu Asp 
            740                 745                 750         


Leu Glu Val Thr Val Ser Asp His Ile Gln Lys Val Leu Lys Pro Asn 
        755                 760                 765             


Phe Ala Ala Ala Trp Glu Glu Val Gly Asp Thr Phe Glu Lys Glu Glu 
    770                 775                 780                 


Thr Phe Ala Leu Ser Ser Thr Lys Thr Leu Glu Glu Ala Val Asn Asn 
785                 790                 795                 800 


Ile Ile Thr Phe Leu Gly Met Gln Pro Cys Glu Arg Ser Asp Lys Val 
                805                 810                 815     


Pro Glu Asn Lys Asn Ser His Ser Leu Tyr Leu Ala Gly Ile Phe Arg 
            820                 825                 830         


Gly Gly Tyr Asp Leu Leu Val Arg Ser Arg Leu Ala Leu Ala Asp Gly 
        835                 840                 845             


Val Thr Met Gln Val Thr Val Arg Ser Lys Glu Arg Thr Pro Val Asp 
    850                 855                 860                 


Val Ile Leu Ala Ser Val Gly 
865                 870     


<210>  28
<211>  768
<212>  PRT
<213>  Homo sapiens

<300>
<308>   NCBI/EAW79270
<309>  2006-12-18
<313>  (1)..(768)

<400>  28

Met Ile Leu Thr Lys Asp Met Thr Gly Lys Glu Asp Asn Tyr Arg Gly 
1               5                   10                  15      


Pro Ala Val Arg Ala Leu Cys Gln Ile Thr Asp Ser Thr Met Leu Gln 
            20                  25                  30          


Ala Ile Glu Arg Tyr Met Lys Gln Ala Ile Val Asp Lys Val Pro Ser 
        35                  40                  45              


Val Ser Ser Ser Ala Leu Val Ser Ser Leu His Leu Leu Lys Cys Ser 
    50                  55                  60                  


Phe Asp Val Val Lys Arg Trp Val Asn Glu Ala Gln Glu Ala Ala Ser 
65                  70                  75                  80  


Ser Asp Asn Ile Met Val Gln Tyr His Ala Leu Gly Leu Leu Tyr His 
                85                  90                  95      


Val Arg Lys Asn Asp Arg Leu Ala Val Asn Lys Met Ile Ser Lys Val 
            100                 105                 110         


Thr Arg His Gly Leu Lys Ser Pro Phe Ala Tyr Cys Met Met Ile Arg 
        115                 120                 125             


Val Ala Ser Lys Gln Leu Glu Glu Glu Asp Gly Ser Arg Asp Ser Pro 
    130                 135                 140                 


Leu Phe Asp Phe Ile Glu Ser Cys Leu Arg Asn Lys His Glu Met Val 
145                 150                 155                 160 


Val Tyr Glu Ala Ala Ser Ala Ile Val Asn Leu Pro Gly Cys Ser Ala 
                165                 170                 175     


Lys Glu Leu Ala Pro Ala Val Ser Val Leu Gln Leu Phe Cys Ser Ser 
            180                 185                 190         


Pro Lys Ala Ala Leu Arg Tyr Ala Ala Val Arg Thr Leu Asn Lys Val 
        195                 200                 205             


Ala Met Lys His Pro Ser Ala Val Thr Ala Cys Asn Leu Asp Leu Glu 
    210                 215                 220                 


Asn Leu Val Thr Asp Ser Asn Arg Ser Ile Ala Thr Leu Ala Ile Thr 
225                 230                 235                 240 


Thr Leu Leu Lys Thr Gly Ser Glu Ser Ser Ile Asp Arg Leu Met Lys 
                245                 250                 255     


Gln Ile Ser Ser Phe Met Ser Glu Ile Ser Asp Glu Phe Lys Val Val 
            260                 265                 270         


Val Val Gln Ala Ile Ser Ala Leu Cys Gln Lys Tyr Pro Arg Lys His 
        275                 280                 285             


Ala Val Leu Met Asn Phe Leu Phe Thr Met Leu Arg Glu Glu Gly Gly 
    290                 295                 300                 


Phe Glu Tyr Lys Arg Ala Ile Val Asp Cys Ile Ile Ser Ile Ile Glu 
305                 310                 315                 320 


Glu Asn Ser Glu Ser Lys Glu Thr Gly Leu Ser His Leu Cys Glu Phe 
                325                 330                 335     


Ile Glu Asp Cys Glu Phe Thr Val Leu Ala Thr Arg Ile Leu His Leu 
            340                 345                 350         


Leu Gly Gln Glu Gly Pro Lys Thr Thr Asn Pro Ser Lys Tyr Ile Arg 
        355                 360                 365             


Phe Ile Tyr Asn Arg Val Val Leu Glu His Glu Glu Val Arg Ala Gly 
    370                 375                 380                 


Ala Val Ser Ala Leu Ala Lys Phe Gly Ala Gln Asn Glu Glu Met Leu 
385                 390                 395                 400 


Pro Ser Ile Leu Val Leu Leu Lys Arg Cys Val Met Asp Asp Asp Asn 
                405                 410                 415     


Glu Val Arg Asp Arg Ala Thr Phe Tyr Leu Asn Val Leu Glu Gln Lys 
            420                 425                 430         


Gln Lys Ala Leu Asn Ala Gly Tyr Ile Leu Asn Gly Leu Thr Val Ser 
        435                 440                 445             


Ile Pro Gly Leu Glu Arg Ala Leu Gln Gln Tyr Thr Leu Glu Pro Ser 
    450                 455                 460                 


Glu Lys Pro Phe Asp Leu Lys Ser Val Pro Leu Ala Thr Ala Pro Met 
465                 470                 475                 480 


Ala Glu Gln Arg Thr Glu Ser Thr Pro Ile Thr Ala Val Lys Gln Pro 
                485                 490                 495     


Glu Lys Val Ala Ala Thr Arg Gln Glu Ile Phe Gln Glu Gln Leu Ala 
            500                 505                 510         


Ala Val Pro Glu Phe Arg Gly Leu Gly Pro Leu Phe Lys Ser Ser Pro 
        515                 520                 525             


Glu Pro Val Ala Leu Thr Glu Ser Glu Thr Glu Tyr Val Ile Arg Cys 
    530                 535                 540                 


Thr Lys His Thr Phe Thr Asn His Met Val Phe Gln Phe Asp Cys Thr 
545                 550                 555                 560 


Asn Thr Leu Asn Asp Gln Thr Leu Glu Asn Val Thr Val Gln Met Glu 
                565                 570                 575     


Pro Thr Glu Ala Tyr Glu Val Leu Cys Tyr Val Pro Ala Arg Ser Leu 
            580                 585                 590         


Pro Tyr Asn Gln Pro Gly Thr Cys Tyr Thr Leu Val Ala Leu Pro Lys 
        595                 600                 605             


Glu Asp Pro Thr Ala Val Ala Cys Thr Phe Ser Cys Met Met Lys Phe 
    610                 615                 620                 


Thr Val Lys Asp Cys Asp Pro Thr Thr Gly Glu Thr Asp Asp Glu Gly 
625                 630                 635                 640 


Tyr Glu Asp Glu Tyr Val Leu Glu Asp Leu Glu Val Thr Val Ala Asp 
                645                 650                 655     


His Ile Gln Lys Val Met Lys Leu Asn Phe Glu Ala Ala Trp Asp Glu 
            660                 665                 670         


Val Gly Asp Glu Phe Glu Lys Glu Glu Thr Phe Thr Leu Ser Thr Ile 
        675                 680                 685             


Lys Thr Leu Glu Glu Ala Val Gly Asn Ile Val Lys Phe Leu Gly Met 
    690                 695                 700                 


His Pro Cys Glu Arg Ser Asp Lys Val Pro Asp Asn Lys Asn Thr His 
705                 710                 715                 720 


Thr Leu Leu Leu Ala Gly Val Phe Arg Gly Gly His Asp Ile Leu Val 
                725                 730                 735     


Arg Ser Arg Leu Leu Leu Leu Asp Thr Val Thr Met Gln Val Thr Ala 
            740                 745                 750         


Arg Ser Leu Glu Glu Leu Pro Val Asp Ile Ile Leu Ala Ser Val Gly 
        755                 760                 765             


<210>  29
<211>  177
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProtKB/P61923
<309>  2009-05-05
<313>  (1)..(177)

<400>  29

Met Glu Ala Leu Ile Leu Glu Pro Ser Leu Tyr Thr Val Lys Ala Ile 
1               5                   10                  15      


Leu Ile Leu Asp Asn Asp Gly Asp Arg Leu Phe Ala Lys Tyr Tyr Asp 
            20                  25                  30          


Asp Thr Tyr Pro Ser Val Lys Glu Gln Lys Ala Phe Glu Lys Asn Ile 
        35                  40                  45              


Phe Asn Lys Thr His Arg Thr Asp Ser Glu Ile Ala Leu Leu Glu Gly 
    50                  55                  60                  


Leu Thr Val Val Tyr Lys Ser Ser Ile Asp Leu Tyr Phe Tyr Val Ile 
65                  70                  75                  80  


Gly Ser Ser Tyr Glu Asn Glu Leu Met Leu Met Ala Val Leu Asn Cys 
                85                  90                  95      


Leu Phe Asp Ser Leu Ser Gln Met Leu Arg Lys Asn Val Glu Lys Arg 
            100                 105                 110         


Ala Leu Leu Glu Asn Met Glu Gly Leu Phe Leu Ala Val Asp Glu Ile 
        115                 120                 125             


Val Asp Gly Gly Val Ile Leu Glu Ser Asp Pro Gln Gln Val Val His 
    130                 135                 140                 


Arg Val Ala Leu Arg Gly Glu Asp Val Pro Leu Thr Glu Gln Thr Val 
145                 150                 155                 160 


Ser Gln Val Leu Gln Ser Ala Lys Glu Gln Ile Lys Trp Ser Leu Leu 
                165                 170                 175     


Arg 
    


<210>  30
<211>  210
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/NP_057513
<309>  2009-03-29
<313>  (1)..(210)

<400>  30

Met Gln Arg Pro Glu Ala Trp Pro Arg Pro His Pro Gly Glu Gly Ala 
1               5                   10                  15      


Ala Ala Ala Gln Ala Gly Gly Pro Ala Pro Pro Ala Arg Ala Gly Glu 
            20                  25                  30          


Pro Ser Gly Leu Arg Leu Gln Glu Pro Ser Leu Tyr Thr Ile Lys Ala 
        35                  40                  45              


Val Phe Ile Leu Asp Asn Asp Gly Arg Arg Leu Leu Ala Lys Tyr Tyr 
    50                  55                  60                  


Asp Asp Thr Phe Pro Ser Met Lys Glu Gln Met Val Phe Glu Lys Asn 
65                  70                  75                  80  


Val Phe Asn Lys Thr Ser Arg Thr Glu Ser Glu Ile Ala Phe Phe Gly 
                85                  90                  95      


Gly Met Thr Ile Val Tyr Lys Asn Ser Ile Asp Leu Phe Leu Tyr Val 
            100                 105                 110         


Val Gly Ser Ser Tyr Glu Asn Glu Leu Met Leu Met Ser Val Leu Thr 
        115                 120                 125             


Cys Leu Phe Glu Ser Leu Asn His Met Leu Arg Lys Asn Val Glu Lys 
    130                 135                 140                 


Arg Trp Leu Leu Glu Asn Met Asp Gly Ala Phe Leu Val Leu Asp Glu 
145                 150                 155                 160 


Ile Val Asp Gly Gly Val Ile Leu Glu Ser Asp Pro Gln Gln Val Ile 
                165                 170                 175     


Gln Lys Val Asn Phe Arg Ala Asp Asp Gly Gly Leu Thr Glu Gln Ser 
            180                 185                 190         


Val Ala Gln Val Leu Gln Ser Ala Lys Glu Gln Ile Lys Trp Ser Leu 
        195                 200                 205             


Leu Lys 
    210 


