SEQUENCE LISTING

<110>   NOVARTIS AG
<110>   OREFICI, GRAZIELLA

<120>   DIAGNOSIS OF NEUROPSYCHIATRIC AND BEHAVIOURAL DISORDERS
        
<130>   P052478WO

<150>   GB0903858.9
<151>   2009-03-05

<160>   53

<170>   SeqWin99, version 1.02

<210>   1
<211>   398
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (17)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   1
Met Lys Lys Arg Ile Leu Ser Ala Val Leu Val Ser Gly Val Thr Leu 
1               5                   10                  15      

Gly Ala Ala Thr Thr Val Gly Ala Glu Asp Leu Ser Thr Lys Ile Ala 
            20                  25                  30          

Lys Gln Asp Ser Ile Ile Ser Asn Leu Thr Thr Glu Gln Lys Ala Ala 
        35                  40                  45              

Gln Asn Gln Val Ser Ala Leu Gln Ala Gln Val Ser Ser Leu Gln Ser 
    50                  55                  60                  

Glu Gln Asp Lys Leu Thr Ala Arg Asn Thr Glu Leu Glu Ala Leu Ser 
65                  70                  75                  80  

Lys Arg Phe Glu Gln Glu Ile Lys Ala Leu Thr Ser Gln Ile Val Ala 
                85                  90                  95      

Arg Asn Glu Lys Leu Lys Asn Gln Ala Arg Ser Ala Tyr Lys Asn Asn 
            100                 105                 110         

Glu Thr Ser Gly Tyr Ile Asn Ala Leu Leu Asn Ser Lys Ser Ile Ser 
        115                 120                 125             

Asp Val Val Asn Arg Leu Val Ala Ile Asn Arg Ala Val Ser Ala Asn 
    130                 135                 140                 

Ala Lys Leu Leu Glu Gln Gln Lys Ala Asp Lys Val Ser Leu Glu Glu 
145                 150                 155                 160 

Lys Gln Ala Ala Asn Gln Thr Ala Ile Asn Thr Ile Ala Ala Asn Met 
                165                 170                 175     

Ala Met Ala Glu Glu Asn Gln Asn Thr Leu Arg Thr Gln Gln Ala Asn 
            180                 185                 190         

Leu Val Ala Ala Thr Ala Asn Leu Ala Leu Gln Leu Ala Ser Ala Thr 
        195                 200                 205             

Glu Asp Lys Ala Asn Leu Val Ala Gln Lys Glu Ala Ala Glu Lys Ala 
    210                 215                 220                 

Ala Ala Glu Ala Leu Ala Gln Glu Gln Ala Ala Lys Val Lys Ala Gln 
225                 230                 235                 240 

Glu Gln Ala Ala Gln Gln Ala Ala Ser Val Glu Ala Ala Lys Ser Ala 
                245                 250                 255     

Ile Thr Pro Ala Pro Gln Ala Thr Pro Ala Ala Gln Ser Ser Asn Ala 
            260                 265                 270         

Ile Glu Pro Ala Ala Leu Thr Ala Pro Ala Ala Pro Ser Ala Gly Pro 
        275                 280                 285             

Gln Thr Ser Tyr Asp Ser Ser Asn Thr Tyr Pro Val Gly Gln Cys Thr 
    290                 295                 300                 

Trp Gly Ala Lys Ser Leu Ala Pro Trp Ala Gly Asn Asn Trp Gly Asn 
305                 310                 315                 320 

Gly Gly Gln Trp Ala Tyr Ser Ala Gln Ala Ala Gly Tyr Arg Thr Gly 
                325                 330                 335     

Ser Thr Pro Met Val Gly Ala Ile Ala Val Trp Asn Asp Gly Gly Tyr 
            340                 345                 350         

Gly His Val Ala Val Val Val Glu Val Gln Ser Ala Ser Ser Ile Arg 
        355                 360                 365             

Val Met Glu Ser Asn Tyr Ser Gly Arg Gln Tyr Ile Ala Asp His Arg 
    370                 375                 380                 

Gly Trp Phe Asn Pro Thr Gly Val Thr Phe Ile Tyr Pro His 
385                 390                 395             

<210>   2
<211>   374
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (24)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   2
Met Lys Lys Phe His Arg Phe Leu Val Ser Gly Val Ile Leu Leu Gly 
1               5                   10                  15      

Phe Asn Gly Leu Val Pro Thr Met Pro Ser Thr Leu Ile Ser Gln Gln 
            20                  25                  30          

Glu Asn Leu Val His Ala Ala Val Leu Gly Asp Asn Tyr Pro Ser Lys 
        35                  40                  45              

Trp Lys Lys Gly Asn Gly Ile Asp Ser Trp Asn Met Tyr Ile Arg Gln 
    50                  55                  60                  

Cys Thr Ser Phe Ala Ala Phe Arg Leu Ser Ser Ala Asn Gly Phe Gln 
65                  70                  75                  80  

Leu Pro Lys Gly Tyr Gly Asn Ala Cys Thr Trp Gly His Ile Ala Lys 
                85                  90                  95      

Asn Gln Gly Tyr Pro Val Asn Lys Thr Pro Ser Ile Gly Ala Ile Ala 
            100                 105                 110         

Trp Phe Asp Lys Asn Ala Tyr Gln Ser Asn Ala Ala Tyr Gly His Val 
        115                 120                 125             

Ala Trp Val Ala Asp Ile Arg Gly Asp Thr Val Thr Ile Glu Glu Tyr 
    130                 135                 140                 

Asn Tyr Asn Ala Gly Gln Gly Pro Glu Arg Tyr His Lys Arg Gln Ile 
145                 150                 155                 160 

Pro Lys Ser Gln Val Ser Gly Tyr Ile His Phe Lys Asp Leu Ser Ser 
                165                 170                 175     

Gln Thr Ser His Ser Tyr Pro Arg Gln Leu Lys His Ile Ser Gln Ala 
            180                 185                 190         

Ser Phe Asp Pro Ser Gly Thr Tyr His Phe Thr Thr Arg Leu Pro Val 
        195                 200                 205             

Lys Gly Gln Thr Ser Ile Asp Ser Pro Asp Leu Ala Tyr Tyr Glu Ala 
    210                 215                 220                 

Gly Gln Ser Val Tyr Tyr Asp Lys Val Val Thr Ala Gly Gly Tyr Thr 
225                 230                 235                 240 

Trp Leu Ser Tyr Leu Ser Phe Ser Gly Asn Arg Arg Tyr Ile Pro Ile 
                245                 250                 255     

Lys Glu Pro Ala Gln Ser Val Val Gln Asn Asp Asn Thr Lys Pro Ser 
            260                 265                 270         

Ile Lys Val Gly Asp Thr Val Thr Phe Pro Gly Val Phe Arg Val Asp 
        275                 280                 285             

Gln Leu Val Asn Asn Leu Ile Val Asn Lys Glu Leu Ala Gly Gly Asp 
    290                 295                 300                 

Pro Thr Pro Leu Asn Trp Ile Asp Pro Thr Pro Leu Asp Glu Thr Asp 
305                 310                 315                 320 

Asn Gln Gly Lys Val Leu Gly Asp Gln Ile Leu Arg Val Gly Glu Tyr 
                325                 330                 335     

Phe Ile Val Thr Gly Ser Tyr Lys Val Leu Lys Ile Asp Gln Pro Ser 
            340                 345                 350         

Asn Gly Ile Tyr Val Gln Ile Gly Ser Arg Gly Thr Trp Val Asn Ala 
        355                 360                 365             

Asp Lys Ala Asn Lys Leu 
    370                 

<210>   3
<211>   292
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (37)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   3
Met Ile Arg Lys Tyr Asp Arg Thr Ser Thr Lys Lys Lys Ser Leu Asn 
1               5                   10                  15      

Trp Ile Trp Leu Ile Ile Ala Phe Phe Met Ile Ser Ser Phe Ile Gly 
            20                  25                  30          

Gly Ser Ser Phe Thr Glu Ser Leu Leu Asp Ile Leu Pro Ala Ile Ala 
        35                  40                  45              

Ile Gly Gly Thr Gly Tyr Ala Ile Phe Arg Val Arg Ser His Gln Lys 
    50                  55                  60                  

Arg Leu Ala Lys Ala Lys Ile Ala Lys Gln Leu Glu Asp Leu Lys Ala 
65                  70                  75                  80  

Lys Ile Gln Leu Ala Asp Arg Lys Val Arg Leu Leu Asp Thr Tyr Leu 
                85                  90                  95      

Ala Asp His Asp Asp Phe Gln Tyr Asn Val Leu Ala Gln Gln Leu Leu 
            100                 105                 110         

Pro Gln Leu Ser Asp Ile Lys Ala Lys Ala Ile Thr Leu Lys Asp Gln 
        115                 120                 125             

Leu Asp Pro Gln Ile Tyr Arg Arg Ile Thr Lys Lys Ala Asn Asp Val 
    130                 135                 140                 

Glu Ser Asp Ile Thr Leu Gln Leu Glu Thr Leu Gln Ile Ala Thr Thr 
145                 150                 155                 160 

Leu Asn Pro Gln Pro Leu Lys Thr Pro Ser Pro Asn Leu Ile Asn Lys 
                165                 170                 175     

Ala Pro Glu Leu Lys Pro Tyr Tyr Asp Asn Ile Gln Thr Asp His Gln 
            180                 185                 190         

Ala Ile Leu Ala Lys Ile Gln Gly Ala Asp Asn Gln Glu Glu Leu Leu 
        195                 200                 205             

Ala Leu His Asp Ala Asn Met Arg Arg Phe Glu Asp Ile Leu Thr Gly 
    210                 215                 220                 

Tyr Leu Lys Ile Lys Glu Glu Pro Lys Asn Tyr Tyr Asn Ala Ala Ala 
225                 230                 235                 240 

Arg Leu Glu Gln Ala Lys Gln Ala Ile Gln Gln Phe Asp Glu Asp Leu 
                245                 250                 255     

Asp Glu Thr Leu Arg Arg Leu Asn Glu Ser Asp Leu Lys Asp Phe Asp 
            260                 265                 270         

Ile Ser Leu Arg Ile Met Gln Gly Ala Thr Gln Arg Arg Thr Thr His 
        275                 280                 285             

His Gln Lys Asp 
    290         

<210>   4
<211>   571
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (31)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   4
Met Ser Asn Lys Lys Thr Phe Lys Lys Tyr Ser Arg Val Ala Gly Leu 
1               5                   10                  15      

Leu Thr Ala Ala Leu Ile Ile Gly Asn Leu Val Thr Ala Asn Ala Glu 
            20                  25                  30          

Ser Asn Lys Gln Asn Thr Ala Ser Thr Glu Thr Thr Thr Thr Asn Glu 
        35                  40                  45              

Gln Pro Lys Pro Glu Ser Ser Glu Leu Thr Thr Glu Lys Ala Gly Gln 
    50                  55                  60                  

Lys Thr Asp Asp Met Leu Asn Ser Asn Asp Met Ile Lys Leu Ala Pro 
65                  70                  75                  80  

Lys Glu Met Pro Leu Glu Ser Ala Glu Lys Glu Glu Lys Lys Ser Glu 
                85                  90                  95      

Asp Lys Lys Lys Ser Glu Glu Asp His Thr Glu Glu Ile Asn Asp Lys 
            100                 105                 110         

Ile Tyr Ser Leu Asn Tyr Asn Glu Leu Glu Val Leu Ala Lys Asn Gly 
        115                 120                 125             

Glu Thr Ile Glu Asn Phe Val Pro Lys Glu Gly Val Lys Lys Ala Asp 
    130                 135                 140                 

Lys Phe Ile Val Ile Glu Arg Lys Lys Lys Asn Ile Asn Thr Thr Pro 
145                 150                 155                 160 

Val Asp Ile Ser Ile Ile Asp Ser Val Thr Asp Arg Thr Tyr Pro Ala 
                165                 170                 175     

Ala Leu Gln Leu Ala Asn Lys Gly Phe Thr Glu Asn Lys Pro Asp Ala 
            180                 185                 190         

Val Val Thr Lys Arg Asn Pro Gln Lys Ile His Ile Asp Leu Pro Gly 
        195                 200                 205             

Met Gly Asp Lys Ala Thr Val Glu Val Asn Asp Pro Thr Tyr Ala Asn 
    210                 215                 220                 

Val Ser Thr Ala Ile Asp Asn Leu Val Asn Gln Trp His Asp Asn Tyr 
225                 230                 235                 240 

Ser Gly Gly Asn Thr Leu Pro Ala Arg Thr Gln Tyr Thr Glu Ser Met 
                245                 250                 255     

Val Tyr Ser Lys Ser Gln Ile Glu Ala Ala Leu Asn Val Asn Ser Lys 
            260                 265                 270         

Ile Leu Asp Gly Thr Leu Gly Ile Asp Phe Lys Ser Ile Ser Lys Gly 
        275                 280                 285             

Glu Lys Lys Val Met Ile Ala Ala Tyr Lys Gln Ile Phe Tyr Thr Val 
    290                 295                 300                 

Ser Ala Asn Leu Pro Asn Asn Pro Ala Asp Val Phe Asp Lys Ser Val 
305                 310                 315                 320 

Thr Phe Lys Glu Leu Gln Arg Lys Gly Val Ser Asn Glu Ala Pro Pro 
                325                 330                 335     

Leu Phe Val Ser Asn Val Ala Tyr Gly Arg Thr Val Phe Val Lys Leu 
            340                 345                 350         

Glu Thr Ser Ser Lys Ser Asn Asp Val Glu Ala Ala Phe Ser Ala Ala 
        355                 360                 365             

Leu Lys Gly Thr Asp Val Lys Thr Asn Gly Lys Tyr Ser Asp Ile Leu 
    370                 375                 380                 

Glu Asn Ser Ser Phe Thr Ala Val Val Leu Gly Gly Asp Ala Ala Glu 
385                 390                 395                 400 

His Asn Lys Val Val Thr Lys Asp Phe Asp Val Ile Arg Asn Val Ile 
                405                 410                 415     

Lys Asp Asn Ala Thr Phe Ser Arg Lys Asn Pro Ala Tyr Pro Ile Ser 
            420                 425                 430         

Tyr Thr Ser Val Phe Leu Lys Asn Asn Lys Ile Ala Gly Val Asn Asn 
        435                 440                 445             

Arg Thr Glu Tyr Val Glu Thr Thr Ser Thr Glu Tyr Thr Ser Gly Lys 
    450                 455                 460                 

Ile Asn Leu Ser His Gln Gly Ala Tyr Val Ala Gln Tyr Glu Ile Leu 
465                 470                 475                 480 

Trp Asp Glu Ile Asn Tyr Asp Asp Lys Gly Lys Glu Val Ile Thr Lys 
                485                 490                 495     

Arg Arg Trp Asp Asn Asn Trp Tyr Ser Lys Thr Ser Pro Phe Ser Thr 
            500                 505                 510         

Val Ile Pro Leu Gly Ala Asn Ser Arg Asn Ile Arg Ile Met Ala Arg 
        515                 520                 525             

Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Lys Val Ile Asp Glu 
    530                 535                 540                 

Arg Asp Val Lys Leu Ser Lys Glu Ile Asn Val Asn Ile Ser Gly Ser 
545                 550                 555                 560 

Thr Leu Ser Pro Tyr Gly Ser Ile Thr Tyr Lys 
                565                 570     

<210>   5
<211>   439
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (21)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   5
Met Asn Met Lys Lys Leu Ala Ser Leu Ala Met Leu Gly Ala Ser Val 
1               5                   10                  15      

Leu Gly Leu Ala Ala Cys Gly Gly Lys Ser Gln Lys Glu Ala Gly Ala 
            20                  25                  30          

Ser Lys Ser Asp Thr Ala Lys Thr Glu Ile Thr Trp Trp Ala Phe Pro 
        35                  40                  45              

Val Phe Thr Gln Glu Lys Ala Glu Asp Gly Val Gly Thr Tyr Glu Lys 
    50                  55                  60                  

Lys Leu Ile Ala Ala Phe Glu Lys Ala Asn Pro Glu Ile Lys Val Lys 
65                  70                  75                  80  

Leu Glu Thr Ile Asp Phe Thr Ser Gly Pro Glu Lys Ile Thr Thr Ala 
                85                  90                  95      

Ile Glu Ala Gly Thr Ala Pro Asp Val Leu Phe Asp Ala Pro Gly Arg 
            100                 105                 110         

Ile Ile Gln Tyr Gly Lys Asn Gly Lys Leu Ala Asp Leu Asn Asp Leu 
        115                 120                 125             

Phe Thr Glu Glu Phe Thr Lys Asp Val Asn Asn Asp Lys Leu Ile Gln 
    130                 135                 140                 

Ala Ser Lys Ala Gly Asp Thr Ala Tyr Met Tyr Pro Ile Ser Ser Ala 
145                 150                 155                 160 

Pro Phe Tyr Met Ala Leu Asn Lys Lys Met Leu Lys Asp Ala Gly Val 
                165                 170                 175     

Leu Asp Leu Val Lys Glu Gly Trp Thr Thr Asp Asp Phe Glu Lys Val 
            180                 185                 190         

Leu Lys Ala Leu Lys Asp Lys Gly Tyr Asn Pro Gly Ser Phe Phe Ala 
        195                 200                 205             

Asn Gly Gln Gly Gly Asp Gln Gly Pro Arg Ala Phe Phe Ala Asn Leu 
    210                 215                 220                 

Tyr Ser Ser His Ile Thr Asp Asp Lys Val Thr Lys Tyr Thr Thr Asp 
225                 230                 235                 240 

Asp Ala Asn Ser Ile Lys Ala Met Thr Lys Ile Ser Asn Trp Ile Lys 
                245                 250                 255     

Asp Gly Leu Met Met Asn Gly Ser Gln Tyr Asp Gly Ser Ala Asp Ile 
            260                 265                 270         

Gln Asn Phe Ala Asn Gly Gln Thr Ser Phe Thr Ile Leu Trp Ala Pro 
        275                 280                 285             

Ala Gln Pro Gly Ile Gln Ala Lys Leu Leu Glu Ala Ser Lys Val Asp 
    290                 295                 300                 

Tyr Leu Glu Ile Pro Phe Pro Ser Asp Asp Gly Lys Pro Glu Leu Glu 
305                 310                 315                 320 

Tyr Leu Val Asn Gly Phe Ala Val Phe Asn Asn Lys Asp Glu Gln Lys 
                325                 330                 335     

Val Ala Ala Ser Lys Thr Phe Ile Gln Phe Ile Ala Asp Asp Lys Glu 
            340                 345                 350         

Trp Gly Pro Lys Asn Val Val Arg Thr Gly Ala Phe Pro Val Arg Thr 
        355                 360                 365             

Ser Tyr Gly Asp Leu Tyr Lys Asp Lys Arg Met Glu Lys Ile Ala Glu 
    370                 375                 380                 

Trp Thr Lys Phe Tyr Ser Pro Tyr Tyr Asn Thr Ile Asp Gly Phe Ala 
385                 390                 395                 400 

Glu Met Arg Thr Leu Trp Phe Pro Met Val Gln Ala Val Ser Asn Gly 
                405                 410                 415     

Asp Glu Lys Pro Glu Asp Ala Leu Lys Ala Phe Thr Glu Lys Ala Asn 
            420                 425                 430         

Lys Thr Ile Lys Lys Thr Gln 
        435                 

<210>   6
<211>   873
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (26)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (850) ... (873)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   6
Met Asp Leu Glu Gln Thr Lys Pro Asn Gln Val Lys Gln Lys Ile Ala 
1               5                   10                  15      

Leu Thr Ser Thr Ile Ala Leu Leu Ser Ala Ser Val Gly Val Ser His 
            20                  25                  30          

Gln Val Lys Ala Asp Asp Arg Ala Ser Gly Glu Thr Lys Ala Ser Asn 
        35                  40                  45              

Thr His Asp Asp Ser Leu Pro Lys Pro Glu Thr Ile Gln Glu Ala Lys 
    50                  55                  60                  

Ala Thr Ile Asp Ala Val Glu Lys Thr Leu Ser Gln Gln Lys Ala Glu 
65                  70                  75                  80  

Leu Thr Glu Leu Ala Thr Ala Leu Thr Lys Thr Thr Ala Glu Ile Asn 
                85                  90                  95      

His Leu Lys Glu Gln Gln Asp Asn Glu Gln Lys Ala Leu Thr Ser Ala 
            100                 105                 110         

Gln Glu Ile Tyr Thr Asn Thr Leu Ala Ser Ser Glu Glu Thr Leu Leu 
        115                 120                 125             

Ala Gln Gly Ala Glu His Gln Arg Glu Leu Thr Ala Thr Glu Thr Glu 
    130                 135                 140                 

Leu His Asn Ala Gln Ala Asp Gln His Ser Lys Glu Thr Ala Leu Ser 
145                 150                 155                 160 

Glu Gln Lys Ala Ser Ile Ser Ala Glu Thr Thr Arg Ala Gln Asp Leu 
                165                 170                 175     

Val Glu Gln Val Lys Thr Ser Glu Gln Asn Ile Ala Lys Leu Asn Ala 
            180                 185                 190         

Met Ile Ser Asn Pro Asp Ala Ile Thr Lys Ala Ala Gln Thr Ala Asn 
        195                 200                 205             

Asp Asn Thr Lys Ala Leu Ser Ser Glu Leu Glu Lys Ala Lys Ala Asp 
    210                 215                 220                 

Leu Glu Asn Gln Lys Ala Lys Val Lys Lys Gln Leu Thr Glu Glu Leu 
225                 230                 235                 240 

Ala Ala Gln Lys Ala Ala Leu Ala Glu Lys Glu Ala Glu Leu Ser Arg 
                245                 250                 255     

Leu Lys Ser Ser Ala Pro Ser Thr Gln Asp Ser Ile Val Gly Asn Asn 
            260                 265                 270         

Thr Met Lys Ala Pro Gln Gly Tyr Pro Leu Glu Glu Leu Lys Lys Leu 
        275                 280                 285             

Glu Ala Ser Gly Tyr Ile Gly Ser Ala Ser Tyr Asn Asn Tyr Tyr Lys 
    290                 295                 300                 

Glu His Ala Asp Gln Ile Ile Ala Lys Ala Ser Pro Gly Asn Gln Leu 
305                 310                 315                 320 

Asn Gln Tyr Gln Asp Ile Pro Ala Asp Arg Asn Arg Phe Val Asp Pro 
                325                 330                 335     

Asp Asn Leu Thr Pro Glu Val Gln Asn Glu Leu Ala Gln Phe Ala Ala 
            340                 345                 350         

His Met Ile Asn Ser Val Arg Arg Gln Leu Gly Leu Pro Pro Val Thr 
        355                 360                 365             

Val Thr Ala Gly Ser Gln Glu Phe Ala Arg Leu Leu Ser Thr Ser Tyr 
    370                 375                 380                 

Lys Lys Thr His Gly Asn Thr Arg Pro Ser Phe Val Tyr Gly Gln Pro 
385                 390                 395                 400 

Gly Val Ser Gly His Tyr Gly Val Gly Pro His Asp Lys Thr Ile Ile 
                405                 410                 415     

Glu Asp Ser Ala Gly Ala Ser Gly Leu Ile Arg Asn Asp Asp Asn Met 
            420                 425                 430         

Tyr Glu Asn Ile Gly Ala Phe Asn Asp Val His Thr Val Asn Gly Ile 
        435                 440                 445             

Lys Arg Gly Ile Tyr Asp Ser Ile Lys Tyr Met Leu Phe Thr Asp His 
    450                 455                 460                 

Leu His Gly Asn Thr Tyr Gly His Ala Ile Asn Phe Leu Arg Val Asp 
465                 470                 475                 480 

Lys His Asn Pro Asn Ala Pro Val Tyr Leu Gly Phe Ser Thr Ser Asn 
                485                 490                 495     

Val Gly Ser Leu Asn Glu His Phe Val Met Phe Pro Glu Ser Asn Ile 
            500                 505                 510         

Ala Asn His Gln Arg Phe Asn Lys Thr Pro Ile Lys Ala Val Gly Ser 
        515                 520                 525             

Thr Lys Asp Tyr Ala Gln Arg Val Gly Thr Val Ser Asp Thr Ile Ala 
    530                 535                 540                 

Ala Ile Lys Gly Lys Val Ser Ser Leu Glu Asn Arg Leu Ser Ala Ile 
545                 550                 555                 560 

His Gln Glu Ala Asp Ile Met Ala Ala Gln Ala Lys Val Ser Gln Leu 
                565                 570                 575     

Gln Gly Lys Leu Ala Ser Thr Leu Lys Gln Ser Asp Ser Leu Asn Leu 
            580                 585                 590         

Gln Val Arg Gln Leu Asn Asp Thr Lys Gly Ser Leu Arg Thr Glu Leu 
        595                 600                 605             

Leu Ala Ala Lys Ala Lys Gln Ala Gln Leu Glu Ala Thr Arg Asp Gln 
    610                 615                 620                 

Ser Leu Ala Lys Leu Ala Ser Leu Lys Ala Ala Leu His Gln Thr Glu 
625                 630                 635                 640 

Ala Leu Ala Glu Gln Ala Ala Ala Arg Val Thr Ala Leu Val Ala Lys 
                645                 650                 655     

Lys Ala His Leu Gln Tyr Leu Arg Asp Phe Lys Leu Asn Pro Asn Arg 
            660                 665                 670         

Leu Gln Val Ile Arg Glu Arg Ile Asp Asn Thr Lys Gln Asp Leu Ala 
        675                 680                 685             

Lys Thr Thr Ser Ser Leu Leu Asn Ala Gln Glu Ala Leu Ala Ala Leu 
    690                 695                 700                 

Gln Ala Lys Gln Ser Ser Leu Glu Ala Thr Ile Ala Thr Thr Glu His 
705                 710                 715                 720 

Gln Leu Thr Leu Leu Lys Thr Leu Ala Asn Glu Lys Glu Tyr Arg His 
                725                 730                 735     

Leu Asp Glu Asp Ile Ala Thr Val Pro Asp Leu Gln Val Ala Pro Pro 
            740                 745                 750         

Leu Thr Gly Val Lys Pro Leu Ser Tyr Ser Lys Ile Asp Thr Thr Pro 
        755                 760                 765             

Leu Val Gln Glu Met Val Lys Glu Thr Lys Gln Leu Leu Glu Ala Ser 
    770                 775                 780                 

Ala Arg Leu Ala Ala Glu Asn Thr Ser Leu Val Ala Glu Ala Leu Val 
785                 790                 795                 800 

Gly Gln Thr Ser Glu Met Val Ala Ser Asn Ala Ile Val Ser Lys Ile 
                805                 810                 815     

Thr Ser Ser Ile Thr Gln Pro Ser Ser Lys Thr Ser Tyr Gly Ser Gly 
            820                 825                 830         

Ser Ser Thr Thr Ser Asn Leu Ile Ser Asp Val Asp Glu Ser Thr Gln 
        835                 840                 845             

Arg Ala Leu Lys Ala Gly Val Val Met Leu Ala Ala Val Gly Leu Thr 
    850                 855                 860                 

Gly Phe Arg Phe Arg Lys Glu Ser Lys 
865                 870             

<210>   7
<211>   298
<212>   PRT
<213>   Streptococcus pyogenes

<400>   7
Ser Val Gly Val Ser His Gln Val Lys Ala Asp Asp Arg Ala Ser Gly 
1               5                   10                  15      

Glu Thr Lys Ala Ser Asn Thr His Asp Asp Ser Leu Pro Lys Pro Glu 
            20                  25                  30          

Thr Ile Gln Glu Ala Lys Ala Thr Ile Asp Ala Val Glu Lys Thr Leu 
        35                  40                  45              

Ser Gln Gln Lys Ala Glu Leu Thr Glu Leu Ala Thr Ala Leu Thr Lys 
    50                  55                  60                  

Thr Thr Ala Glu Ile Asn His Leu Lys Glu Gln Gln Asp Asn Glu Gln 
65                  70                  75                  80  

Lys Ala Leu Thr Ser Ala Gln Glu Ile Tyr Thr Asn Thr Leu Ala Ser 
                85                  90                  95      

Ser Glu Glu Thr Leu Leu Ala Gln Gly Ala Glu His Gln Arg Glu Leu 
            100                 105                 110         

Thr Ala Thr Glu Thr Glu Leu His Asn Ala Gln Ala Asp Gln His Ser 
        115                 120                 125             

Lys Glu Thr Ala Leu Ser Glu Gln Lys Ala Ser Ile Ser Ala Glu Thr 
    130                 135                 140                 

Thr Arg Ala Gln Asp Leu Val Glu Gln Val Lys Thr Ser Glu Gln Asn 
145                 150                 155                 160 

Ile Ala Lys Leu Asn Ala Met Ile Ser Asn Pro Asp Ala Ile Thr Lys 
                165                 170                 175     

Ala Ala Gln Thr Ala Asn Asp Asn Thr Lys Ala Leu Ser Ser Glu Leu 
            180                 185                 190         

Glu Lys Ala Lys Ala Asp Leu Glu Asn Gln Lys Ala Lys Val Lys Lys 
        195                 200                 205             

Gln Leu Thr Glu Glu Leu Ala Ala Gln Lys Ala Ala Leu Ala Glu Lys 
    210                 215                 220                 

Glu Ala Glu Leu Ser Arg Leu Lys Ser Ser Ala Pro Ser Thr Gln Asp 
225                 230                 235                 240 

Ser Ile Val Gly Asn Asn Thr Met Lys Ala Pro Gln Gly Tyr Pro Leu 
                245                 250                 255     

Glu Glu Leu Lys Lys Leu Glu Ala Ser Gly Tyr Ile Gly Ser Ala Ser 
            260                 265                 270         

Tyr Asn Asn Tyr Tyr Lys Glu His Ala Asp Gln Ile Ile Ala Lys Ala 
        275                 280                 285             

Ser Pro Gly Asn Gln Leu Asn Gln Tyr Gln 
    290                 295             

<210>   8
<211>   420
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   8
Met Thr Lys Glu Lys Leu Val Ala Phe Ser Gln Ala His Ala Glu Pro 
1               5                   10                  15      

Ala Trp Leu Gln Glu Arg Arg Leu Ala Ala Leu Glu Ala Ile Pro Asn 
            20                  25                  30          

Leu Glu Leu Pro Thr Ile Glu Arg Val Lys Phe His Arg Trp Asn Leu 
        35                  40                  45              

Gly Asp Gly Thr Leu Thr Glu Asn Glu Ser Leu Ala Ser Val Pro Asp 
    50                  55                  60                  

Phe Ile Ala Ile Gly Asp Asn Pro Lys Leu Val Gln Val Gly Thr Gln 
65                  70                  75                  80  

Thr Val Leu Glu Gln Leu Pro Met Ala Leu Ile Asp Lys Gly Val Val 
                85                  90                  95      

Phe Ser Asp Phe Tyr Thr Ala Leu Glu Glu Ile Pro Glu Val Ile Glu 
            100                 105                 110         

Ala His Phe Gly Gln Ala Leu Ala Phe Asp Glu Asp Lys Leu Ala Ala 
        115                 120                 125             

Tyr His Thr Ala Tyr Phe Asn Ser Ala Ala Val Leu Tyr Val Pro Asp 
    130                 135                 140                 

His Leu Glu Ile Thr Thr Pro Ile Glu Ala Ile Phe Leu Gln Asp Ser 
145                 150                 155                 160 

Asp Ser Asp Val Pro Phe Asn Lys His Val Leu Val Ile Ala Gly Lys 
                165                 170                 175     

Glu Ser Lys Phe Thr Tyr Leu Glu Arg Phe Glu Ser Ile Gly Asn Ala 
            180                 185                 190         

Thr Gln Lys Ile Ser Ala Asn Ile Ser Val Glu Val Ile Ala Gln Ala 
        195                 200                 205             

Gly Ser Gln Ile Lys Phe Ser Ala Ile Asp Arg Leu Gly Pro Ser Val 
    210                 215                 220                 

Thr Thr Tyr Ile Ser Arg Arg Gly Arg Leu Glu Lys Asp Ala Asn Ile 
225                 230                 235                 240 

Asp Trp Ala Leu Ala Val Met Asn Glu Gly Asn Val Ile Ala Asp Phe 
                245                 250                 255     

Asp Ser Asp Leu Ile Gly Gln Gly Ser Gln Ala Asp Leu Lys Val Val 
            260                 265                 270         

Ala Ala Ser Ser Gly Arg Gln Val Gln Gly Ile Asp Thr Arg Val Thr 
        275                 280                 285             

Asn Tyr Gly Gln Arg Thr Val Gly His Ile Leu Gln His Gly Val Ile 
    290                 295                 300                 

Leu Glu Arg Gly Thr Leu Thr Phe Asn Gly Ile Gly His Ile Leu Lys 
305                 310                 315                 320 

Asp Ala Lys Gly Ala Asp Ala Gln Gln Glu Ser Arg Val Leu Met Leu 
                325                 330                 335     

Ser Asp Gln Ala Arg Ala Asp Ala Asn Pro Ile Leu Leu Ile Asp Glu 
            340                 345                 350         

Asn Glu Val Thr Ala Gly His Ala Ala Ser Ile Gly Gln Val Asp Pro 
        355                 360                 365             

Glu Asp Met Tyr Tyr Leu Met Ser Arg Gly Leu Asp Gln Glu Thr Ala 
    370                 375                 380                 

Glu Arg Leu Val Ile Arg Gly Phe Leu Gly Ala Val Ile Ala Glu Ile 
385                 390                 395                 400 

Pro Ile Pro Ser Val Arg Gln Glu Ile Ile Lys Val Leu Asp Glu Lys 
                405                 410                 415     

Leu Leu Asn Arg 
            420 

<210>   9
<211>   656
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (22)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   9
Met Lys Lys Ser Lys Trp Leu Ala Ala Val Ser Val Ala Ile Leu Ser 
1               5                   10                  15      

Val Ser Ala Leu Ala Ala Cys Gly Asn Lys Asn Ala Ser Gly Gly Ser 
            20                  25                  30          

Glu Ala Thr Lys Thr Tyr Lys Tyr Val Phe Val Asn Asp Pro Lys Ser 
        35                  40                  45              

Leu Asp Tyr Ile Leu Thr Asn Gly Gly Gly Thr Thr Asp Val Ile Thr 
    50                  55                  60                  

Gln Met Val Asp Gly Leu Leu Glu Asn Asp Glu Tyr Gly Asn Leu Val 
65                  70                  75                  80  

Pro Ser Leu Ala Lys Asp Trp Lys Val Ser Lys Asp Gly Leu Thr Tyr 
                85                  90                  95      

Thr Tyr Thr Leu Arg Asp Gly Val Ser Trp Tyr Thr Ala Asp Gly Glu 
            100                 105                 110         

Glu Tyr Ala Pro Val Thr Ala Glu Asp Phe Val Thr Gly Leu Lys His 
        115                 120                 125             

Ala Val Asp Asp Lys Ser Asp Ala Leu Tyr Val Val Glu Asp Ser Ile 
    130                 135                 140                 

Lys Asn Leu Lys Ala Tyr Gln Asn Gly Glu Val Asp Phe Lys Glu Val 
145                 150                 155                 160 

Gly Val Lys Ala Leu Asp Asp Lys Thr Val Gln Tyr Thr Leu Asn Lys 
                165                 170                 175     

Pro Glu Ser Tyr Trp Asn Ser Lys Thr Thr Tyr Ser Val Leu Phe Pro 
            180                 185                 190         

Val Asn Ala Lys Phe Leu Lys Ser Lys Gly Lys Asp Phe Gly Thr Thr 
        195                 200                 205             

Asp Pro Ser Ser Ile Leu Val Asn Gly Ala Tyr Phe Leu Ser Ala Phe 
    210                 215                 220                 

Thr Ser Lys Ser Ser Met Glu Phe His Lys Asn Glu Asn Tyr Trp Asp 
225                 230                 235                 240 

Ala Lys Asn Val Gly Ile Glu Ser Val Lys Leu Thr Tyr Ser Asp Gly 
                245                 250                 255     

Ser Asp Pro Gly Ser Phe Tyr Lys Asn Phe Asp Lys Gly Glu Phe Ser 
            260                 265                 270         

Val Ala Arg Leu Tyr Pro Asn Asp Pro Thr Tyr Lys Ser Ala Lys Lys 
        275                 280                 285             

Asn Tyr Ala Asp Asn Ile Thr Tyr Gly Met Leu Thr Gly Asp Ile Arg 
    290                 295                 300                 

His Leu Thr Trp Asn Leu Asn Arg Thr Ser Phe Lys Asn Thr Lys Lys 
305                 310                 315                 320 

Asp Pro Ala Gln Gln Asp Ala Gly Lys Lys Ala Leu Asn Asn Lys Asp 
                325                 330                 335     

Phe Arg Gln Ala Ile Gln Phe Ala Phe Asp Arg Ala Ser Phe Gln Ala 
            340                 345                 350         

Gln Thr Ala Gly Gln Asp Ala Lys Thr Lys Ala Leu Arg Asn Met Leu 
        355                 360                 365             

Val Pro Pro Thr Phe Val Thr Ile Gly Glu Ser Asp Phe Gly Ser Glu 
    370                 375                 380                 

Val Glu Lys Glu Met Ala Lys Leu Gly Asp Glu Trp Lys Asp Val Asn 
385                 390                 395                 400 

Leu Ala Asp Ala Gln Asp Gly Phe Tyr Asn Pro Glu Lys Ala Lys Ala 
                405                 410                 415     

Glu Phe Ala Lys Ala Lys Glu Ala Leu Thr Ala Glu Gly Val Thr Phe 
            420                 425                 430         

Pro Val Gln Leu Asp Tyr Pro Val Asp Gln Ala Asn Ala Ala Thr Val 
        435                 440                 445             

Gln Glu Ala Gln Ser Phe Lys Gln Ser Val Glu Ala Ser Leu Gly Lys 
    450                 455                 460                 

Glu Asn Val Ile Val Asn Val Leu Glu Thr Glu Thr Ser Thr His Glu 
465                 470                 475                 480 

Ala Gln Gly Phe Tyr Ala Glu Thr Pro Glu Gln Gln Asp Tyr Asp Ile 
                485                 490                 495     

Ile Ser Ser Trp Trp Gly Pro Asp Tyr Gln Asp Pro Arg Thr Tyr Leu 
            500                 505                 510         

Asp Ile Met Ser Pro Val Gly Gly Gly Ser Val Ile Gln Lys Leu Gly 
        515                 520                 525             

Ile Lys Ala Gly Gln Asn Lys Asp Val Val Ala Ala Ala Gly Leu Asp 
    530                 535                 540                 

Thr Tyr Gln Thr Leu Leu Asp Glu Ala Ala Ala Ile Thr Asp Asp Asn 
545                 550                 555                 560 

Asp Ala Arg Tyr Lys Ala Tyr Ala Lys Ala Gln Ala Tyr Leu Thr Asp 
                565                 570                 575     

Asn Ala Val Asp Ile Pro Val Val Ala Leu Gly Gly Thr Pro Arg Val 
            580                 585                 590         

Thr Lys Ala Val Pro Phe Ser Gly Gly Phe Ser Trp Ala Gly Ser Lys 
        595                 600                 605             

Gly Pro Leu Ala Tyr Lys Gly Met Lys Leu Gln Asp Lys Pro Val Thr 
    610                 615                 620                 

Val Lys Gln Tyr Glu Lys Ala Lys Glu Lys Trp Met Lys Ala Lys Ala 
625                 630                 635                 640 

Lys Ser Asn Ala Lys Tyr Ala Glu Lys Leu Ala Asp His Val Glu Lys 
                645                 650                 655     


<210>   10
<211>   1647
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (33)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (1614) ... (1647)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   10
Met Glu Lys Lys Gln Arg Phe Ser Leu Arg Lys Tyr Lys Ser Gly Thr 
1               5                   10                  15      

Phe Ser Val Leu Ile Gly Ser Val Phe Leu Val Met Thr Thr Thr Val 
            20                  25                  30          

Ala Ala Asp Glu Leu Ser Thr Met Ser Glu Pro Thr Ile Thr Asn His 
        35                  40                  45              

Ala Gln Gln Gln Ala Gln His Leu Thr Asn Thr Glu Leu Ser Ser Ala 
    50                  55                  60                  

Glu Ser Lys Ser Gln Asp Thr Ser Gln Ile Thr Leu Lys Thr Asn Arg 
65                  70                  75                  80  

Glu Lys Glu Gln Ser Gln Asp Leu Val Ser Glu Pro Thr Thr Thr Glu 
                85                  90                  95      

Leu Ala Asp Thr Asp Ala Ala Ser Met Ala Asn Thr Gly Ser Asp Ala 
            100                 105                 110         

Thr Gln Lys Ser Ala Ser Leu Pro Pro Val Asn Thr Asp Val His Asp 
        115                 120                 125             

Trp Val Lys Thr Lys Gly Ala Trp Asp Lys Gly Tyr Lys Gly Gln Gly 
    130                 135                 140                 

Lys Val Val Ala Val Ile Asp Thr Gly Ile Asp Pro Ala His Gln Ser 
145                 150                 155                 160 

Met Arg Ile Ser Asp Val Ser Thr Ala Lys Val Lys Ser Lys Glu Asp 
                165                 170                 175     

Met Leu Ala Arg Gln Lys Ala Ala Gly Ile Asn Tyr Gly Ser Trp Ile 
            180                 185                 190         

Asn Asp Lys Val Val Phe Ala His Asn Tyr Val Glu Asn Ser Asp Asn 
        195                 200                 205             

Ile Lys Glu Asn Gln Phe Glu Asp Phe Asp Glu Asp Trp Glu Asn Phe 
    210                 215                 220                 

Glu Phe Asp Ala Glu Ala Glu Pro Lys Ala Ile Lys Lys His Lys Ile 
225                 230                 235                 240 

Tyr Arg Pro Gln Ser Thr Gln Ala Pro Lys Glu Thr Val Ile Lys Thr 
                245                 250                 255     

Glu Glu Thr Asp Gly Ser His Asp Ile Asp Trp Thr Gln Thr Asp Asp 
            260                 265                 270         

Asp Thr Lys Tyr Glu Ser His Gly Met His Val Thr Gly Ile Val Ala 
        275                 280                 285             

Gly Asn Ser Lys Glu Ala Ala Ala Thr Gly Glu Arg Phe Leu Gly Ile 
    290                 295                 300                 

Ala Pro Glu Ala Gln Val Met Phe Met Arg Val Phe Ala Asn Asp Ile 
305                 310                 315                 320 

Met Gly Ser Ala Glu Ser Leu Phe Ile Lys Ala Ile Glu Asp Ala Val 
                325                 330                 335     

Ala Leu Gly Ala Asp Val Ile Asn Leu Ser Leu Gly Thr Ala Asn Gly 
            340                 345                 350         

Ala Gln Leu Ser Gly Ser Lys Pro Leu Met Glu Ala Ile Glu Lys Ala 
        355                 360                 365             

Lys Lys Ala Gly Val Ser Val Val Val Ala Ala Gly Asn Glu Arg Val 
    370                 375                 380                 

Tyr Gly Ser Asp His Asp Asp Pro Leu Ala Thr Asn Pro Asp Tyr Gly 
385                 390                 395                 400 

Leu Val Gly Ser Pro Ser Thr Gly Arg Thr Pro Thr Ser Val Ala Ala 
                405                 410                 415     

Ile Asn Ser Lys Trp Val Ile Gln Arg Leu Met Thr Val Lys Glu Leu 
            420                 425                 430         

Glu Asn Arg Ala Asp Leu Asn His Gly Lys Ala Ile Tyr Ser Glu Ser 
        435                 440                 445             

Val Asp Phe Lys Asp Ile Lys Asp Ser Leu Gly Tyr Asp Lys Ser His 
    450                 455                 460                 

Gln Phe Ala Tyr Val Lys Glu Ser Thr Asp Ala Gly Tyr Asn Ala Gln 
465                 470                 475                 480 

Asp Val Lys Gly Lys Ile Ala Leu Ile Glu Arg Asp Pro Asn Lys Thr 
                485                 490                 495     

Tyr Asp Glu Met Ile Ala Leu Ala Lys Lys His Gly Ala Leu Gly Val 
            500                 505                 510         

Leu Ile Phe Asn Asn Lys Pro Gly Gln Ser Asn Arg Ser Met Arg Leu 
        515                 520                 525             

Thr Ala Asn Gly Met Gly Ile Pro Ser Ala Phe Ile Ser His Glu Phe 
    530                 535                 540                 

Gly Lys Ala Met Ser Gln Leu Asn Gly Asn Gly Thr Gly Ser Leu Glu 
545                 550                 555                 560 

Phe Asp Ser Val Val Ser Lys Ala Pro Ser Gln Lys Gly Asn Glu Met 
                565                 570                 575     

Asn His Phe Ser Asn Trp Gly Leu Thr Ser Asp Gly Tyr Leu Lys Pro 
            580                 585                 590         

Asp Ile Thr Ala Pro Gly Gly Asp Ile Tyr Ser Thr Tyr Asn Asp Asn 
        595                 600                 605             

His Tyr Gly Ser Gln Thr Gly Thr Ser Met Ala Ser Pro Gln Ile Ala 
    610                 615                 620                 

Gly Ala Ser Leu Leu Val Lys Gln Tyr Leu Glu Lys Thr Gln Pro Asn 
625                 630                 635                 640 

Leu Pro Lys Glu Lys Ile Ala Asp Ile Val Lys Asn Leu Leu Met Ser 
                645                 650                 655     

Asn Ala Gln Ile His Val Asn Pro Glu Thr Lys Thr Thr Thr Ser Pro 
            660                 665                 670         

Arg Gln Gln Gly Ala Gly Leu Leu Asn Ile Asp Gly Ala Val Thr Ser 
        675                 680                 685             

Gly Leu Tyr Val Thr Gly Lys Asp Asn Tyr Gly Ser Ile Ser Leu Gly 
    690                 695                 700                 

Asn Ile Thr Asp Thr Met Thr Phe Asp Val Thr Val His Asn Leu Ser 
705                 710                 715                 720 

Asn Lys Asp Lys Thr Leu Arg Tyr Asp Thr Glu Leu Leu Thr Asp His 
                725                 730                 735     

Val Asp Pro Gln Lys Gly Arg Phe Thr Leu Thr Ser His Ser Leu Lys 
            740                 745                 750         

Thr Tyr Gln Gly Gly Glu Val Thr Val Pro Ala Asn Gly Lys Val Thr 
        755                 760                 765             

Val Arg Val Thr Met Asp Val Ser Gln Phe Thr Lys Glu Leu Thr Lys 
    770                 775                 780                 

Gln Met Pro Asn Gly Tyr Tyr Leu Glu Gly Phe Val Arg Phe Arg Asp 
785                 790                 795                 800 

Ser Gln Asp Asp Gln Leu Asn Arg Val Asn Ile Pro Phe Val Gly Phe 
                805                 810                 815     

Lys Gly Gln Phe Glu Asn Leu Ala Val Ala Glu Glu Ser Ile Tyr Arg 
            820                 825                 830         

Leu Lys Ser Gln Gly Lys Thr Gly Phe Tyr Phe Asp Glu Ser Gly Pro 
        835                 840                 845             

Lys Asp Asp Ile Tyr Val Gly Lys His Phe Thr Gly Leu Val Thr Leu 
    850                 855                 860                 

Gly Ser Glu Thr Asn Val Ser Thr Lys Thr Ile Ser Asp Asn Gly Leu 
865                 870                 875                 880 

His Thr Leu Gly Thr Phe Lys Asn Ala Asp Gly Lys Phe Ile Leu Glu 
                885                 890                 895     

Lys Asn Ala Gln Gly Asn Pro Val Leu Ala Ile Ser Pro Asn Gly Asp 
            900                 905                 910         

Asn Asn Gln Asp Phe Ala Ala Phe Lys Gly Val Phe Leu Arg Lys Tyr 
        915                 920                 925             

Gln Gly Leu Lys Ala Ser Val Tyr His Ala Ser Asp Lys Glu His Lys 
    930                 935                 940                 

Asn Pro Leu Trp Val Ser Pro Glu Ser Phe Lys Gly Asp Lys Asn Phe 
945                 950                 955                 960 

Asn Ser Asp Ile Arg Phe Ala Lys Ser Thr Thr Leu Leu Gly Thr Ala 
                965                 970                 975     

Phe Ser Gly Lys Ser Leu Thr Gly Ala Glu Leu Pro Asp Gly His Tyr 
            980                 985                 990         

His Tyr Val Val Ser Tyr Tyr Pro Asp Val Val Gly Ala Lys Arg Gln 
        995                 1000                1005            

Glu Met Thr Phe Asp Met Ile Leu Asp Arg Gln Lys Pro Val Leu Ser 
    1010                1015                1020                

Gln Ala Thr Phe Asp Pro Glu Thr Asn Arg Phe Lys Pro Glu Pro Leu 
1025                1030                1035                1040

Lys Asp Arg Gly Leu Ala Gly Val Arg Lys Asp Ser Val Phe Tyr Leu 
                1045                1050                1055    

Glu Arg Lys Asp Asn Lys Pro Tyr Thr Val Thr Ile Asn Asp Ser Tyr 
            1060                1065                1070        

Lys Tyr Val Ser Val Glu Asp Asn Lys Thr Phe Val Glu Arg Gln Ala 
        1075                1080                1085            

Asp Gly Ser Phe Ile Leu Pro Leu Asp Lys Ala Lys Leu Gly Asp Phe 
    1090                1095                1100                

Tyr Tyr Met Val Glu Asp Phe Ala Gly Asn Val Ala Ile Ala Lys Leu 
1105                1110                1115                1120

Gly Asp His Leu Pro Gln Thr Leu Gly Lys Thr Pro Ile Lys Leu Lys 
                1125                1130                1135    

Leu Thr Asp Gly Asn Tyr Gln Thr Lys Glu Thr Leu Lys Asp Asn Leu 
            1140                1145                1150        

Glu Met Thr Gln Ser Asp Thr Gly Leu Val Thr Asn Gln Ala Gln Leu 
        1155                1160                1165            

Ala Val Val His Arg Asn Gln Pro Gln Ser Gln Leu Thr Lys Met Asn 
    1170                1175                1180                

Gln Asp Phe Phe Ile Ser Pro Asn Glu Asp Gly Asn Lys Asp Phe Val 
1185                1190                1195                1200

Ala Phe Lys Gly Leu Lys Asn Asn Val Tyr Asn Asp Leu Thr Val Asn 
                1205                1210                1215    

Val Tyr Ala Lys Asp Asp His Gln Lys Gln Thr Pro Ile Trp Ser Ser 
            1220                1225                1230        

Gln Ala Gly Ala Ser Val Ser Ala Ile Glu Ser Thr Ala Trp Tyr Gly 
        1235                1240                1245            

Ile Thr Ala Arg Gly Ser Lys Val Met Pro Gly Asp Tyr Gln Tyr Val 
    1250                1255                1260                

Val Thr Tyr Arg Asp Glu His Gly Lys Glu His Gln Lys Gln Tyr Thr 
1265                1270                1275                1280

Ile Ser Val Asn Asp Lys Lys Pro Met Ile Thr Gln Gly Arg Phe Asp 
                1285                1290                1295    

Thr Ile Asn Gly Val Asp His Phe Thr Pro Asp Lys Thr Lys Ala Leu 
            1300                1305                1310        

Asp Ser Ser Gly Ile Val Arg Glu Glu Val Phe Tyr Leu Ala Lys Lys 
        1315                1320                1325            

Asn Gly Arg Lys Phe Asp Val Thr Glu Gly Lys Asp Gly Ile Thr Val 
    1330                1335                1340                

Ser Asp Asn Lys Val Tyr Ile Pro Lys Asn Pro Asp Gly Ser Tyr Thr 
1345                1350                1355                1360

Ile Ser Lys Arg Asp Gly Val Thr Leu Ser Asp Tyr Tyr Tyr Leu Val 
                1365                1370                1375    

Glu Asp Arg Ala Gly Asn Val Ser Phe Ala Thr Leu Arg Asp Leu Lys 
            1380                1385                1390        

Ala Val Gly Lys Asp Lys Ala Val Val Asn Phe Gly Leu Asp Leu Pro 
        1395                1400                1405            

Val Pro Glu Asp Lys Gln Ile Val Asn Phe Thr Tyr Leu Val Arg Asp 
    1410                1415                1420                

Ala Asp Gly Lys Pro Ile Glu Asn Leu Glu Tyr Tyr Asn Asn Ser Gly 
1425                1430                1435                1440

Asn Ser Leu Ile Leu Pro Tyr Gly Lys Tyr Thr Val Glu Leu Leu Thr 
                1445                1450                1455    

Tyr Asp Thr Asn Ala Ala Lys Leu Glu Ser Asp Lys Ile Val Ser Phe 
            1460                1465                1470        

Thr Leu Ser Ala Asp Asn Asn Phe Gln Gln Val Thr Phe Lys Ile Thr 
        1475                1480                1485            

Met Leu Ala Thr Ser Gln Ile Thr Ala His Phe Asp His Leu Leu Pro 
    1490                1495                1500                

Glu Gly Ser Arg Val Ser Leu Lys Thr Ala Gln Asp Gln Leu Ile Pro 
1505                1510                1515                1520

Leu Glu Gln Ser Leu Tyr Val Pro Lys Ala Tyr Gly Lys Thr Val Gln 
                1525                1530                1535    

Glu Gly Thr Tyr Glu Val Val Val Ser Leu Pro Lys Gly Tyr Arg Ile 
            1540                1545                1550        

Glu Gly Asn Thr Lys Val Asn Thr Leu Pro Asn Glu Val His Glu Leu 
        1555                1560                1565            

Ser Leu Arg Leu Val Lys Val Gly Asp Ala Ser Asp Ser Thr Gly Asp 
    1570                1575                1580                

His Lys Val Met Ser Lys Asn Asn Ser Gln Ala Leu Thr Ala Ser Ala 
1585                1590                1595                1600

Thr Pro Thr Lys Ser Thr Thr Ser Ala Thr Ala Lys Ala Leu Pro Ser 
                1605                1610                1615    

Thr Gly Glu Lys Met Gly Leu Lys Leu Arg Ile Val Gly Leu Val Leu 
            1620                1625                1630        

Leu Gly Leu Thr Cys Val Phe Ser Arg Lys Lys Ser Thr Lys Asp 
        1635                1640                1645        

<210>   11
<211>   865
<212>   PRT
<213>   Streptococcus pyogenes

<400>   11
Ala Asp Glu Leu Ser Thr Met Ser Glu Pro Thr Ile Thr Asn His Ala 
1               5                   10                  15      

Gln Gln Gln Ala Gln His Leu Thr Asn Thr Glu Leu Ser Ser Ala Glu 
            20                  25                  30          

Ser Lys Ser Gln Asp Thr Ser Gln Ile Thr Leu Lys Thr Asn Arg Glu 
        35                  40                  45              

Lys Glu Gln Ser Gln Asp Leu Val Ser Glu Pro Thr Thr Thr Glu Leu 
    50                  55                  60                  

Ala Asp Thr Asp Ala Ala Ser Met Ala Asn Thr Gly Ser Asp Ala Thr 
65                  70                  75                  80  

Gln Lys Ser Ala Ser Leu Pro Pro Val Asn Thr Asp Val His Asp Trp 
                85                  90                  95      

Val Lys Thr Lys Gly Ala Trp Asp Lys Gly Tyr Lys Gly Gln Gly Lys 
            100                 105                 110         

Val Val Ala Val Ile Asp Thr Gly Ile Asp Pro Ala His Gln Ser Met 
        115                 120                 125             

Arg Ile Ser Asp Val Ser Thr Ala Lys Val Lys Ser Lys Glu Asp Met 
    130                 135                 140                 

Leu Ala Arg Gln Lys Ala Ala Gly Ile Asn Tyr Gly Ser Trp Ile Asn 
145                 150                 155                 160 

Asp Lys Val Val Phe Ala His Asn Tyr Val Glu Asn Ser Asp Asn Ile 
                165                 170                 175     

Lys Glu Asn Gln Phe Glu Asp Phe Asp Glu Asp Trp Glu Asn Phe Glu 
            180                 185                 190         

Phe Asp Ala Glu Ala Glu Pro Lys Ala Ile Lys Lys His Lys Ile Tyr 
        195                 200                 205             

Arg Pro Gln Ser Thr Gln Ala Pro Lys Glu Thr Val Ile Lys Thr Glu 
    210                 215                 220                 

Glu Thr Asp Gly Ser His Asp Ile Asp Trp Thr Gln Thr Asp Asp Asp 
225                 230                 235                 240 

Thr Lys Tyr Glu Ser His Gly Met His Val Thr Gly Ile Val Ala Gly 
                245                 250                 255     

Asn Ser Lys Glu Ala Ala Ala Thr Gly Glu Arg Phe Leu Gly Ile Ala 
            260                 265                 270         

Pro Glu Ala Gln Val Met Phe Met Arg Val Phe Ala Asn Asp Ile Met 
        275                 280                 285             

Gly Ser Ala Glu Ser Leu Phe Ile Lys Ala Ile Glu Asp Ala Val Ala 
    290                 295                 300                 

Leu Gly Ala Asp Val Ile Asn Leu Ser Leu Gly Thr Ala Asn Gly Ala 
305                 310                 315                 320 

Gln Leu Ser Gly Ser Lys Pro Leu Met Glu Ala Ile Glu Lys Ala Lys 
                325                 330                 335     

Lys Ala Gly Val Ser Val Val Val Ala Ala Gly Asn Glu Arg Val Tyr 
            340                 345                 350         

Gly Ser Asp His Asp Asp Pro Leu Ala Thr Asn Pro Asp Tyr Gly Leu 
        355                 360                 365             

Val Gly Ser Pro Ser Thr Gly Arg Thr Pro Thr Ser Val Ala Ala Ile 
    370                 375                 380                 

Asn Ser Lys Trp Val Ile Gln Arg Leu Met Thr Val Lys Glu Leu Glu 
385                 390                 395                 400 

Asn Arg Ala Asp Leu Asn His Gly Lys Ala Ile Tyr Ser Glu Ser Val 
                405                 410                 415     

Asp Phe Lys Asp Ile Lys Asp Ser Leu Gly Tyr Asp Lys Ser His Gln 
            420                 425                 430         

Phe Ala Tyr Val Lys Glu Ser Thr Asp Ala Gly Tyr Asn Ala Gln Asp 
        435                 440                 445             

Val Lys Gly Lys Ile Ala Leu Ile Glu Arg Asp Pro Asn Lys Thr Tyr 
    450                 455                 460                 

Asp Glu Met Ile Ala Leu Ala Lys Lys His Gly Ala Leu Gly Val Leu 
465                 470                 475                 480 

Ile Phe Asn Asn Lys Pro Gly Gln Ser Asn Arg Ser Met Arg Leu Thr 
                485                 490                 495     

Ala Asn Gly Met Gly Ile Pro Ser Ala Phe Ile Ser His Glu Phe Gly 
            500                 505                 510         

Lys Ala Met Ser Gln Leu Asn Gly Asn Gly Thr Gly Ser Leu Glu Phe 
        515                 520                 525             

Asp Ser Val Val Ser Lys Ala Pro Ser Gln Lys Gly Asn Glu Met Asn 
    530                 535                 540                 

His Phe Ser Asn Trp Gly Leu Thr Ser Asp Gly Tyr Leu Lys Pro Asp 
545                 550                 555                 560 

Ile Thr Ala Pro Gly Gly Asp Ile Tyr Ser Thr Tyr Asn Asp Asn His 
                565                 570                 575     

Tyr Gly Ser Gln Thr Gly Thr Ser Met Ala Ser Pro Gln Ile Ala Gly 
            580                 585                 590         

Ala Ser Leu Leu Val Lys Gln Tyr Leu Glu Lys Thr Gln Pro Asn Leu 
        595                 600                 605             

Pro Lys Glu Lys Ile Ala Asp Ile Val Lys Asn Leu Leu Met Ser Asn 
    610                 615                 620                 

Ala Gln Ile His Val Asn Pro Glu Thr Lys Thr Thr Thr Ser Pro Arg 
625                 630                 635                 640 

Gln Gln Gly Ala Gly Leu Leu Asn Ile Asp Gly Ala Val Thr Ser Gly 
                645                 650                 655     

Leu Tyr Val Thr Gly Lys Asp Asn Tyr Gly Ser Ile Ser Leu Gly Asn 
            660                 665                 670         

Ile Thr Asp Thr Met Thr Phe Asp Val Thr Val His Asn Leu Ser Asn 
        675                 680                 685             

Lys Asp Lys Thr Leu Arg Tyr Asp Thr Glu Leu Leu Thr Asp His Val 
    690                 695                 700                 

Asp Pro Gln Lys Gly Arg Phe Thr Leu Thr Ser His Ser Leu Lys Thr 
705                 710                 715                 720 

Tyr Gln Gly Gly Glu Val Thr Val Pro Ala Asn Gly Lys Val Thr Val 
                725                 730                 735     

Arg Val Thr Met Asp Val Ser Gln Phe Thr Lys Glu Leu Thr Lys Gln 
            740                 745                 750         

Met Pro Asn Gly Tyr Tyr Leu Glu Gly Phe Val Arg Phe Arg Asp Ser 
        755                 760                 765             

Gln Asp Asp Gln Leu Asn Arg Val Asn Ile Pro Phe Val Gly Phe Lys 
    770                 775                 780                 

Gly Gln Phe Glu Asn Leu Ala Val Ala Glu Glu Ser Ile Tyr Arg Leu 
785                 790                 795                 800 

Lys Ser Gln Gly Lys Thr Gly Phe Tyr Phe Asp Glu Ser Gly Pro Lys 
                805                 810                 815     

Asp Asp Ile Tyr Val Gly Lys His Phe Thr Gly Leu Val Thr Leu Gly 
            820                 825                 830         

Ser Glu Thr Asn Val Ser Thr Lys Thr Ile Ser Asp Asn Gly Leu His 
        835                 840                 845             

Thr Leu Gly Thr Phe Lys Asn Ala Asp Gly Lys Phe Ile Leu Glu Lys 
    850                 855                 860                 

Asn 
865 

<210>   12
<211>   232
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (14)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   12
Met Lys Arg Ile Ile Lys Thr Ile Ile Leu Val Ile Ile Ile Phe His 
1               5                   10                  15      

Gly Tyr Gly Ser Val Lys Ser Asp Ser Glu Asn Ile Lys Asp Val Lys 
            20                  25                  30          

Leu Gln Leu Asn Tyr Ala Tyr Glu Ile Ile Pro Val Asp Tyr Thr Asn 
        35                  40                  45              

Cys Asn Ile Asp Tyr Leu Thr Thr His Asp Phe Tyr Ile Asp Ile Ser 
    50                  55                  60                  

Ser Tyr Lys Lys Lys Asn Phe Ser Val Asp Ser Glu Val Glu Ser Tyr 
65                  70                  75                  80  

Ile Thr Thr Lys Phe Thr Lys Asn Gln Lys Val Asn Ile Phe Gly Leu 
                85                  90                  95      

Pro Tyr Ile Phe Thr Arg Tyr Asp Val Tyr Tyr Ile Tyr Gly Gly Val 
            100                 105                 110         

Thr Pro Ser Val Asn Ser Asn Ser Glu Asn Ser Lys Ile Val Gly Asn 
        115                 120                 125             

Leu Leu Ile Asp Gly Val Gln Gln Lys Thr Leu Ile Asn Pro Ile Lys 
    130                 135                 140                 

Ile Asp Lys Pro Ile Phe Thr Ile Gln Glu Phe Asp Phe Lys Ile Arg 
145                 150                 155                 160 

Gln Tyr Leu Met Gln Thr Tyr Lys Ile Tyr Asp Pro Asn Ser Pro Tyr 
                165                 170                 175     

Ile Lys Gly Gln Leu Glu Ile Ala Ile Asn Gly Asn Lys His Glu Ser 
            180                 185                 190         

Phe Asn Leu Tyr Asp Ala Thr Ser Ser Ser Thr Arg Ser Asp Ile Phe 
        195                 200                 205             

Lys Lys Tyr Lys Asp Asn Lys Thr Ile Asn Met Lys Asp Phe Ser His 
    210                 215                 220                 

Phe Asp Ile Tyr Leu Trp Thr Lys 
225                 230         

<210>   13
<211>   319
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (40)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   13
Met Lys Leu Ala Val Leu Gly Thr Gly Met Ile Val Lys Glu Val Leu 
1               5                   10                  15      

Pro Val Leu Gln Lys Ile Asp Gly Ile Asp Leu Val Ala Ile Leu Ser 
            20                  25                  30          

Thr Val Arg Ser Leu Thr Thr Ala Lys Asp Leu Ala Lys Ala His His 
        35                  40                  45              

Met Pro Leu Ala Thr Ser Lys Tyr Glu Ala Ile Leu Gly Asn Glu Glu 
    50                  55                  60                  

Ile Asp Thr Val Tyr Ile Gly Leu Pro Asn His Leu His Phe Ala Tyr 
65                  70                  75                  80  

Ala Lys Glu Ala Leu Leu Ala Gly Lys His Val Ile Cys Glu Lys Pro 
                85                  90                  95      

Phe Thr Met Thr Ala Gly Glu Leu Asp Glu Leu Val Val Ile Ala Arg 
            100                 105                 110         

Lys Arg Lys Leu Ile Leu Leu Glu Ala Ile Thr Asn Gln Tyr Leu Ser 
        115                 120                 125             

Asn Met Thr Phe Ile Lys Glu His Leu Asp Gln Leu Gly Asp Ile Lys 
    130                 135                 140                 

Ile Val Glu Cys Asn Tyr Ser Gln Tyr Ser Ser Arg Tyr Asp Ala Phe 
145                 150                 155                 160 

Lys Arg Gly Asp Ile Ala Pro Ala Phe Asn Pro Lys Met Gly Gly Gly 
                165                 170                 175     

Ala Leu Arg Asp Leu Asn Ile Tyr Asn Ile His Phe Val Val Gly Leu 
            180                 185                 190         

Phe Gly Arg Pro Lys Thr Val Gln Tyr Leu Ala Asn Val Glu Lys Gly 
        195                 200                 205             

Ile Asp Thr Ser Gly Met Leu Val Met Asp Tyr Glu Gln Phe Lys Val 
    210                 215                 220                 

Val Cys Ile Gly Ala Lys Asp Cys Thr Ala Glu Ile Lys Ser Thr Ile 
225                 230                 235                 240 

Gln Gly Asn Lys Gly Ser Leu Ala Val Leu Gly Ala Thr Asn Thr Leu 
                245                 250                 255     

Pro Gln Val Gln Leu Ser Leu His Gly His Glu Pro Gln Val Ile Asn 
            260                 265                 270         

His Asn Lys His Asp His Arg Met Tyr Glu Glu Phe Val Ala Phe Arg 
        275                 280                 285             

Asp Met Ile Asp Gln Arg Asp Phe Glu Lys Val Asn Gln Ala Leu Glu 
    290                 295                 300                 

His Ser Arg Ala Val Met Ala Val Leu Glu Arg Ala Val His Ser 
305                 310                 315                 

<210>   14
<211>   268
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (19)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   14
Met Lys Lys Leu Leu Ser Leu Ser Leu Val Ala Ile Ser Leu Leu Asn 
1               5                   10                  15      

Leu Ser Ala Cys Glu Ser Val Asp Arg Ala Ile Lys Gly Asp Lys Tyr 
            20                  25                  30          

Ile Asp Glu Lys Thr Ala Lys Glu Glu Ser Glu Ala Ala Ser Lys Ala 
        35                  40                  45              

Tyr Glu Glu Ser Ile Gln Lys Ala Leu Lys Ala Asp Ala Ser Gln Phe 
    50                  55                  60                  

Pro Gln Leu Thr Lys Glu Val Gly Lys Glu Glu Ala Lys Val Val Met 
65                  70                  75                  80  

Arg Thr Ser Gln Gly Asp Ile Thr Leu Lys Leu Phe Pro Lys Tyr Ala 
                85                  90                  95      

Pro Leu Ala Val Glu Asn Phe Leu Thr His Ala Lys Lys Gly Tyr Tyr 
            100                 105                 110         

Asp Asn Leu Thr Phe His Arg Val Ile Asn Asp Phe Met Ile Gln Ser 
        115                 120                 125             

Gly Asp Pro Lys Gly Asp Gly Thr Gly Gly Glu Ser Ile Trp Lys Gly 
    130                 135                 140                 

Lys Asp Pro Lys Lys Asp Ala Gly Asn Gly Phe Val Asn Glu Ile Ser 
145                 150                 155                 160 

Pro Phe Leu Tyr His Ile Arg Gly Ala Leu Ala Met Ala Asn Ala Gly 
                165                 170                 175     

Ala Asn Thr Asn Gly Ser Gln Phe Tyr Ile Asn Gln Asn Lys Lys Asn 
            180                 185                 190         

Gln Ser Lys Gly Leu Ser Ser Thr Asn Tyr Pro Lys Pro Ile Ile Ser 
        195                 200                 205             

Ala Tyr Glu His Gly Gly Asn Pro Ser Leu Asp Gly Gly Tyr Thr Val 
    210                 215                 220                 

Phe Gly Gln Val Ile Asp Gly Met Asp Val Val Asp Lys Ile Ala Ala 
225                 230                 235                 240 

Thr Ser Ile Asn Gln Asn Asp Lys Pro Glu Gln Asp Ile Thr Ile Thr 
                245                 250                 255     

Ser Ile Asp Ile Val Lys Asp Tyr Arg Phe Lys Asn 
            260                 265             

<210>   15
<211>   515
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (17)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   15
Met Lys Lys Lys Ile Leu Leu Met Met Ser Leu Ile Ser Val Phe Phe 
1               5                   10                  15      

Ala Trp Gln Leu Thr Gln Ala Lys Gln Val Leu Ala Glu Gly Lys Val 
            20                  25                  30          

Lys Val Val Thr Thr Phe Tyr Pro Val Tyr Glu Phe Thr Lys Gly Val 
        35                  40                  45              

Ile Gly Asn Asp Gly Asp Val Phe Met Leu Met Lys Ala Gly Thr Glu 
    50                  55                  60                  

Pro His Asp Phe Glu Pro Ser Thr Lys Asp Ile Lys Lys Ile Gln Asp 
65                  70                  75                  80  

Ala Asp Ala Phe Val Tyr Met Asp Asp Asn Met Glu Thr Trp Val Ser 
                85                  90                  95      

Asp Val Lys Lys Ser Leu Thr Ser Lys Lys Val Thr Ile Val Lys Gly 
            100                 105                 110         

Thr Gly Asn Met Leu Leu Val Ala Gly Ala Gly His Asp His Pro His 
        115                 120                 125             

Glu Asp Ala Asp Lys Lys His Glu His Asn Lys His Ser Glu Glu Gly 
    130                 135                 140                 

His Asn His Ala Phe Asp Pro His Val Trp Leu Ser Pro Tyr Arg Ser 
145                 150                 155                 160 

Ile Thr Val Val Glu Asn Ile Arg Asp Ser Leu Ser Lys Ala Tyr Pro 
                165                 170                 175     

Glu Lys Ala Glu Asn Phe Lys Ala Asn Ala Ala Thr Tyr Ile Glu Lys 
            180                 185                 190         

Leu Lys Glu Leu Asp Lys Asp Tyr Thr Ala Ala Leu Ser Asp Ala Lys 
        195                 200                 205             

Gln Lys Ser Phe Val Thr Gln His Ala Ala Phe Gly Tyr Met Ala Leu 
    210                 215                 220                 

Asp Tyr Gly Leu Asn Gln Ile Ser Ile Asn Gly Val Thr Pro Asp Ala 
225                 230                 235                 240 

Glu Pro Ser Ala Lys Arg Ile Ala Thr Leu Ser Lys Tyr Val Lys Lys 
                245                 250                 255     

Tyr Gly Ile Lys Tyr Ile Tyr Phe Glu Glu Asn Ala Ser Ser Lys Val 
            260                 265                 270         

Ala Lys Thr Leu Ala Lys Glu Ala Gly Val Lys Ala Ala Val Leu Ser 
        275                 280                 285             

Pro Leu Glu Gly Leu Thr Glu Lys Glu Met Lys Ala Gly Gln Asp Tyr 
    290                 295                 300                 

Phe Thr Val Met Arg Lys Asn Leu Glu Thr Leu Arg Leu Thr Thr Asp 
305                 310                 315                 320 

Val Ala Gly Lys Glu Ile Leu Pro Glu Lys Asp Thr Thr Lys Thr Val 
                325                 330                 335     

Tyr Asn Gly Tyr Phe Lys Asp Lys Glu Val Lys Asp Arg Gln Leu Ser 
            340                 345                 350         

Asp Trp Ser Gly Ser Trp Gln Ser Val Tyr Pro Tyr Leu Gln Asp Gly 
        355                 360                 365             

Thr Leu Asp Gln Val Trp Asp Tyr Lys Ala Lys Lys Ser Lys Gly Lys 
    370                 375                 380                 

Met Thr Ala Ala Glu Tyr Lys Asp Tyr Tyr Thr Thr Gly Tyr Lys Thr 
385                 390                 395                 400 

Asp Val Glu Gln Ile Lys Ile Asn Gly Lys Lys Lys Thr Met Thr Phe 
                405                 410                 415     

Val Arg Asn Gly Glu Lys Lys Thr Phe Thr Tyr Thr Tyr Ala Gly Lys 
            420                 425                 430         

Glu Ile Leu Thr Tyr Pro Lys Gly Asn Arg Gly Val Arg Phe Met Phe 
        435                 440                 445             

Glu Ala Lys Glu Ala Asp Ala Gly Glu Phe Lys Tyr Val Gln Phe Ser 
    450                 455                 460                 

Asp His Ala Ile Ala Pro Glu Lys Ala Lys His Phe His Leu Tyr Trp 
465                 470                 475                 480 

Gly Gly Asp Ser Gln Glu Lys Leu His Lys Glu Leu Glu His Trp Pro 
                485                 490                 495     

Thr Tyr Tyr Gly Ser Asp Leu Ser Gly Arg Glu Ile Ala Gln Glu Ile 
            500                 505                 510         

Asn Ala His 
        515 

<210>   16
<211>   2045
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (38)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (2011) ... (2045)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   16
Met Arg Lys Val Lys Lys Val Phe Val Ser Ser Cys Met Leu Leu Thr 
1               5                   10                  15      

Val Gly Leu Gly Val Ala Val Pro Thr Gly Phe Ser Gln Ser Asn Gly 
            20                  25                  30          

Val Met Val Val Lys Ala Ala Glu Val Pro Ala Thr Asp Leu Ser Arg 
        35                  40                  45              

Gln Ala Ser Asp Ser Glu Arg Val Asp Glu Ser Ser Leu Leu Gln Lys 
    50                  55                  60                  

Glu Asn Leu Ser Val Asp Ser Phe Lys Leu Glu Asn Leu Asn Gly Trp 
65                  70                  75                  80  

Glu Ala Glu Asn Asp Thr Ala Gly Asn Leu Gly Lys Phe Lys Asp Pro 
                85                  90                  95      

Asp Ser Ser Gly Tyr Gln Asn Ile Leu Thr Ser Ser Gly Lys Asn Ile 
            100                 105                 110         

Ser Val Ala Val Ala Pro Lys Gly Ser Gly Lys Met Asn Ile Lys Val 
        115                 120                 125             

Thr Lys Arg Ser Asn Phe Gln Gly Gly Tyr Tyr Val Gly Gly Leu Arg 
    130                 135                 140                 

Thr Gln Thr Pro Val Leu Lys Leu Asn Asp Val Tyr Arg Tyr Ser Phe 
145                 150                 155                 160 

Thr Thr Lys Lys Leu Ser Gly Asn Ser Ser Glu Phe Lys Thr Arg Val 
                165                 170                 175     

Lys Pro Val Glu Ser Asn Asn Lys Leu Gly Lys Glu Leu Val Ile Arg 
            180                 185                 190         

Val Asp Asn Lys Asn Val Ser Thr Lys His Asp Trp Leu Pro Asp Ile 
        195                 200                 205             

Ser Asp Gly Thr His Thr Val Asp Phe Thr Gly Leu Asp Lys Lys Leu 
    210                 215                 220                 

Ser Val Ala Phe Arg Phe Ser Pro Arg Gln Thr Ser Asn Val Val Tyr 
225                 230                 235                 240 

Glu Phe Ser Asn Ile Asn Ile Lys Asn Ile Ser Pro Ala Ser Val Pro 
                245                 250                 255     

Ala Ile Pro Ser Lys Val Leu Glu Gly Thr Ser Val Leu Ser Gly Thr 
            260                 265                 270         

Ala Ile Ser Ser Gly Asp Thr Leu Glu Lys Arg Lys Ser Phe Asp Gly 
        275                 280                 285             

Asp Ile Leu Arg Val Tyr Lys Asp Ser Lys Ile Ile Ala Arg Thr Val 
    290                 295                 300                 

Ile Lys Gly Asn Lys Trp Asp Val Lys Leu Ser Lys Pro Leu Ile Ala 
305                 310                 315                 320 

Gly Glu Lys Leu Asp Phe Glu Ile Leu His Pro Arg Ser Gln Asn Val 
                325                 330                 335     

Ser Lys Lys Ile Ser Lys Gln Val Glu Ala Lys Pro Phe Asp Pro Ala 
            340                 345                 350         

Ser Tyr Lys Glu Lys Val Ile Ala Lys Leu Lys Pro Val Tyr Glu Ala 
        355                 360                 365             

Thr Ser Glu Lys Ile Thr Asn Asp Ala Trp Leu Asp Glu Asn Ala Lys 
    370                 375                 380                 

Asp Leu Gln Lys Gln Lys Leu Glu Glu Gln Tyr Ile Ser Gly Lys Val 
385                 390                 395                 400 

Ala Ile Ser Glu Ala Gly Thr Lys Gln Glu Ala Ile Asp Ala Ala Tyr 
                405                 410                 415     

Asn Lys Tyr Ser Ser Gln Thr Asp Pro Asp Ser Leu Pro Ser Gln Tyr 
            420                 425                 430         

Lys Gln Gly Asn Lys Glu Asn Glu Gln Glu Lys Gly Arg Gln Asp Leu 
        435                 440                 445             

Ile Gln Thr Arg Asp Leu Thr Leu Lys Ala Ile Gln Glu Asp Lys Trp 
    450                 455                 460                 

Leu Thr Glu Gln Glu Lys Thr Ile Gln Lys Glu Glu Ala Leu Lys Ala 
465                 470                 475                 480 

Phe Glu Thr Gly Ile Glu Ser Val Asn Gln Thr Val Ser Leu Glu Gln 
                485                 490                 495     

Leu Lys Gln Arg Leu Ile Val Tyr Lys Ala Ser Glu Lys Asp Ser Glu 
            500                 505                 510         

Lys Lys Glu Tyr Pro Glu Ser Ile Pro Asn Gln His Ile Pro Gly Lys 
        515                 520                 525             

Glu Lys Glu Val Lys Ala Ala Lys Gln Glu Glu Leu Lys Lys Leu His 
    530                 535                 540                 

Asp Thr Thr Leu Glu Lys Ile Asn Gln Asp Lys Trp Leu Thr Pro Asp 
545                 550                 555                 560 

Gln Gln Ala Glu Gln Leu Lys Gln Ala Glu Val Thr Phe Lys Lys Gly 
                565                 570                 575     

Gln Glu Ala Ile Lys Ser Ala Gln Thr Leu Thr Gln Leu Glu Thr Asp 
            580                 585                 590         

Leu Ala Asp Tyr Val Ser Glu Asn Glu Gly Lys Gly Asn Ser Ile Pro 
        595                 600                 605             

Asp Lys Tyr Lys Ser Gly Asn Lys Asp Asp Leu Val Asn Lys Ala Glu 
    610                 615                 620                 

Val Lys Leu Lys Glu Ala His Glu Ala Thr Lys Gln Ala Ile Glu Lys 
625                 630                 635                 640 

Asp Pro Trp Leu Ser Pro Glu Gln Lys Lys Ala Gln Lys Glu Lys Ala 
                645                 650                 655     

Lys Ala Arg Leu Asp Glu Gly Leu Lys Ala Leu Lys Ala Ala Asp Ser 
            660                 665                 670         

Leu Glu Ile Leu Lys Val Thr Glu Glu Ala Phe Val Asp Lys Glu Lys 
        675                 680                 685             

Asn Pro Asp Ser Ile Pro Asn Gln His Lys Ala Gly Thr Ala Asp Gln 
    690                 695                 700                 

Ala Arg Lys Gln Ala Leu Asp Ser Leu Asp Lys Glu Val Gln Lys Glu 
705                 710                 715                 720 

Leu Glu Ser Ile Asp Asn Asp Asn Thr Leu Thr Thr Asp Glu Lys Ala 
                725                 730                 735     

Ala Ala Lys Lys Lys Val Asn Asp Ala Tyr Asp Val Ala Lys Gln Thr 
            740                 745                 750         

Ala Met Glu Ala Asn Ser Tyr Glu Asp Leu Thr Thr Ile Lys Asp Glu 
        755                 760                 765             

Phe Leu Ser Asn Leu Pro His Lys Gln Gly Thr Pro Leu Lys Asp Gln 
    770                 775                 780                 

Gln Ser Asp Ala Ile Ala Glu Leu Glu Lys Lys Gln Gln Glu Ile Glu 
785                 790                 795                 800 

Lys Ala Ile Glu Gly Asp Lys Thr Leu Pro Arg Asp Glu Lys Glu Lys 
                805                 810                 815     

Gln Ile Ala Asp Ser Lys Glu Arg Leu Lys Ser Asp Thr Gln Lys Val 
            820                 825                 830         

Lys Asp Ala Lys Asn Ala Asp Ala Ile Lys Lys Ala Phe Glu Glu Gly 
        835                 840                 845             

Lys Val Asn Ile Pro Gln Ala His Ile Pro Gly Asp Leu Asn Lys Asp 
    850                 855                 860                 

Lys Glu Lys Leu Leu Ala Glu Leu Lys Gln Lys Ala Asp Asp Thr Glu 
865                 870                 875                 880 

Lys Ala Ile Asp Val Asp Lys Thr Leu Thr Glu Asp Glu Lys Lys Glu 
                885                 890                 895     

Gln Lys Val Lys Thr Lys Ala Glu Leu Glu Lys Ala Lys Thr Asp Val 
            900                 905                 910         

Lys Asn Thr Gln Thr Arg Glu Glu Leu Asp Lys Lys Val Pro Glu Leu 
        915                 920                 925             

Lys Lys Ala Ile Glu Asp Thr His Val Lys Gly Asn Leu Glu Gly Val 
    930                 935                 940                 

Lys Asn Lys Ala Ile Glu Asp Leu Lys Lys Ala His Thr Glu Thr Val 
945                 950                 955                 960 

Ala Lys Ile Asn Gly Asp Asp Thr Leu Asp Lys Ala Thr Lys Glu Ala 
                965                 970                 975     

Gln Val Lys Glu Ala Asp Lys Ala Leu Ala Ala Gly Lys Asp Ala Ile 
            980                 985                 990         

Thr Lys Ala Asp Asp Ala Asp Lys Val Ser Thr Ala Val Thr Glu His 
        995                 1000                1005            

Thr Pro Lys Ile Lys Ala Ala His Lys Thr Gly Asp Leu Lys Lys Ala 
    1010                1015                1020                

Gln Val Asp Ala Asn Thr Ala Leu Asp Lys Ala Ala Glu Lys Glu Arg 
1025                1030                1035                1040

Gly Glu Ile Asn Lys Asp Ala Thr Leu Thr Thr Glu Asp Lys Ala Lys 
                1045                1050                1055    

Gln Leu Lys Glu Val Glu Thr Ala Leu Thr Lys Ala Lys Asp Asn Val 
            1060                1065                1070        

Lys Ala Ala Lys Thr Ala Asp Ala Ile Asn Asp Ala Arg Asp Lys Gly 
        1075                1080                1085            

Val Ala Thr Ile Asp Ala Val His Lys Ala Gly Gln Asp Leu Gly Ala 
    1090                1095                1100                

Arg Lys Ser Gly Gln Val Ala Lys Leu Glu Glu Ala Ala Lys Ala Thr 
1105                1110                1115                1120

Lys Asp Lys Ile Ser Ala Asp Pro Thr Leu Thr Ser Lys Glu Lys Glu 
                1125                1130                1135    

Glu Gln Ser Lys Ala Val Asp Ala Glu Leu Lys Lys Ala Ile Glu Ala 
            1140                1145                1150        

Val Asn Ala Ala Asp Thr Ala Asp Lys Val Asp Asp Ala Leu Gly Glu 
        1155                1160                1165            

Gly Val Thr Asp Ile Lys Asn Gln His Lys Ser Gly Asp Ser Ile Asp 
    1170                1175                1180                

Ala Arg Arg Glu Ala His Gly Lys Glu Leu Asp Arg Val Ala Gln Glu 
1185                1190                1195                1200

Thr Lys Gly Ala Ile Glu Lys Asp Pro Thr Leu Thr Thr Glu Glu Lys 
                1205                1210                1215    

Ala Lys Gln Val Lys Asp Val Asp Ala Ala Lys Glu Arg Gly Met Ala 
            1220                1225                1230        

Lys Leu Asn Glu Ala Lys Asp Ala Asp Ala Leu Asp Lys Ala Tyr Gly 
        1235                1240                1245            

Glu Gly Val Thr Asp Ile Lys Asn Gln His Lys Ser Gly Asp Pro Val 
    1250                1255                1260                

Asp Ala Arg Arg Gly Leu His Asn Lys Ser Ile Asp Glu Val Ala Gln 
1265                1270                1275                1280

Ala Thr Lys Asp Ala Ile Thr Ala Asp Thr Thr Leu Thr Glu Ala Glu 
                1285                1290                1295    

Lys Glu Thr Gln Arg Gly Asn Val Asp Lys Glu Ala Thr Lys Ala Lys 
            1300                1305                1310        

Glu Glu Leu Ala Lys Ala Lys Asp Ala Asp Ala Leu Asp Lys Ala Tyr 
        1315                1320                1325            

Gly Asp Gly Val Thr Ser Ile Lys Asn Gln His Lys Ser Gly Lys Gly 
    1330                1335                1340                

Leu Asp Val Arg Lys Asp Glu His Lys Lys Ala Leu Glu Ala Val Ala 
1345                1350                1355                1360

Lys Arg Val Thr Ala Glu Ile Glu Ala Asp Pro Thr Leu Thr Pro Glu 
                1365                1370                1375    

Val Arg Glu Gln Gln Lys Ala Glu Val Gln Lys Glu Leu Glu Leu Ala 
            1380                1385                1390        

Thr Asp Lys Ile Ala Glu Ala Lys Asp Ala Asp Glu Ala Asp Lys Ala 
        1395                1400                1405            

Tyr Gly Asp Gly Val Thr Ala Ile Glu Asn Ala His Val Ile Gly Lys 
    1410                1415                1420                

Gly Ile Glu Ala Arg Lys Asp Leu Ala Lys Lys Asp Leu Ala Glu Ala 
1425                1430                1435                1440

Ala Ala Lys Thr Lys Ala Leu Ile Ile Glu Asp Lys Thr Leu Thr Asp 
                1445                1450                1455    

Asp Gln Arg Lys Glu Gln Leu Leu Gly Val Asp Thr Glu Tyr Ala Lys 
            1460                1465                1470        

Gly Ile Glu Asn Ile Asp Ala Ala Lys Asp Ala Ala Gly Val Asp Lys 
        1475                1480                1485            

Ala Tyr Ser Asp Gly Val Arg Asp Ile Leu Ala Gln Tyr Lys Glu Gly 
    1490                1495                1500                

Gln Asn Leu Asn Asp Arg Arg Asn Ala Ala Lys Glu Phe Leu Leu Lys 
1505                1510                1515                1520

Glu Ala Asp Lys Val Thr Lys Leu Ile Asn Asp Asp Pro Thr Leu Thr 
                1525                1530                1535    

His Asp Gln Lys Val Asp Gln Ile Asn Lys Val Glu Gln Ala Lys Leu 
            1540                1545                1550        

Asp Ala Ile Lys Ser Val Asp Asp Ala Gln Thr Ala Asp Ala Ile Asn 
        1555                1560                1565            

Asp Ala Leu Gly Lys Gly Ile Glu Asn Ile Asn Asn Gln Tyr Gln His 
    1570                1575                1580                

Gly Asp Gly Val Asp Val Arg Lys Ala Thr Ala Lys Gly Asp Leu Glu 
1585                1590                1595                1600

Lys Glu Ala Ala Lys Val Lys Ala Leu Ile Ala Lys Asp Pro Thr Leu 
                1605                1610                1615    

Thr Gln Ala Asp Lys Asp Lys Gln Thr Ala Ala Val Asp Ala Ala Lys 
            1620                1625                1630        

Asn Thr Ala Ile Ala Ala Val Asp Lys Ala Thr Thr Thr Glu Gly Ile 
        1635                1640                1645            

Asn Gln Glu Leu Gly Lys Gly Ile Thr Ala Ile Asn Lys Ala Tyr Arg 
    1650                1655                1660                

Pro Gly Glu Gly Val Lys Ala Arg Lys Glu Ala Ala Lys Ala Asp Leu 
1665                1670                1675                1680

Glu Lys Glu Ala Ala Lys Val Lys Ala Leu Ile Thr Asn Asp Pro Thr 
                1685                1690                1695    

Leu Thr Lys Ala Asp Lys Ala Lys Gln Thr Glu Ala Val Ala Lys Ala 
            1700                1705                1710        

Leu Lys Ala Ala Ile Ala Ala Val Asp Lys Ala Thr Thr Ala Glu Gly 
        1715                1720                1725            

Ile Asn Gln Glu Leu Gly Lys Gly Ile Thr Ala Ile Asn Lys Ala Tyr 
    1730                1735                1740                

Arg Pro Gly Glu Gly Val Lys Ala Arg Lys Glu Ala Ala Lys Ala Asp 
1745                1750                1755                1760

Leu Glu Arg Glu Ala Ala Lys Val Arg Glu Ala Ile Ala Asn Asp Pro 
                1765                1770                1775    

Thr Leu Thr Lys Ala Asp Lys Ala Lys Gln Thr Glu Ala Val Ala Lys 
            1780                1785                1790        

Ala Leu Lys Ala Ala Ile Ala Ala Val Asp Lys Ala Thr Thr Ala Glu 
        1795                1800                1805            

Gly Ile Asn Gln Glu Leu Gly Lys Gly Ile Thr Ala Ile Asn Lys Ala 
    1810                1815                1820                

Tyr Arg Pro Gly Glu Gly Val Glu Ala His Lys Glu Ala Ala Lys Ala 
1825                1830                1835                1840

Asn Leu Glu Lys Val Ala Lys Glu Thr Lys Ala Leu Ile Ser Gly Asp 
                1845                1850                1855    

Arg Tyr Leu Ser Glu Thr Glu Lys Ala Val Gln Lys Gln Ala Val Glu 
            1860                1865                1870        

Gln Ala Leu Ala Lys Ala Leu Gly Gln Val Glu Ala Ala Lys Thr Val 
        1875                1880                1885            

Glu Ala Val Lys Leu Ala Glu Asn Leu Gly Thr Val Ala Ile Arg Ser 
    1890                1895                1900                

Ala Tyr Val Ala Gly Leu Ala Lys Asp Thr Asp Gln Ala Thr Ala Ala 
1905                1910                1915                1920

Leu Asn Glu Ala Lys Gln Ala Ala Ile Glu Ala Leu Lys Gln Ala Ala 
                1925                1930                1935    

Ala Glu Thr Leu Ala Lys Ile Thr Thr Asp Ala Lys Leu Thr Glu Ala 
            1940                1945                1950        

Gln Lys Ala Glu Gln Ser Glu Asn Val Ser Leu Ala Leu Lys Thr Ala 
        1955                1960                1965            

Ile Ala Thr Val Arg Ser Ala Gln Ser Ile Ala Ser Val Lys Glu Ala 
    1970                1975                1980                

Lys Asp Lys Gly Ile Thr Ala Ile Arg Ala Ala Tyr Val Pro Asn Lys 
1985                1990                1995                2000

Ala Val Ala Lys Ser Ser Ser Ala Asn His Leu Pro Lys Ser Gly Asp 
                2005                2010                2015    

Ala Asn Ser Ile Val Leu Val Gly Leu Gly Val Met Ser Leu Leu Leu 
            2020                2025                2030        

Gly Met Val Leu Tyr Ser Lys Lys Lys Glu Ser Lys Asp 
        2035                2040                2045

<210>   17
<211>   805
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (25)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   17
Met Asn Thr Tyr Phe Cys Thr His His Lys Gln Leu Leu Leu Tyr Ser 
1               5                   10                  15      

Asn Leu Phe Leu Ser Phe Ala Met Met Gly Gln Gly Thr Ala Ile Tyr 
            20                  25                  30          

Ala Asp Thr Leu Thr Ser Asn Ser Glu Pro Asn Asn Thr Tyr Phe Gln 
        35                  40                  45              

Thr Gln Thr Leu Thr Thr Thr Asp Ser Glu Lys Lys Val Val Gln Pro 
    50                  55                  60                  

Gln Gln Lys Asp Tyr Tyr Thr Glu Leu Leu Asp Gln Trp Asn Ser Ile 
65                  70                  75                  80  

Ile Ala Gly Asn Asp Ala Tyr Asp Lys Thr Asn Pro Asp Met Val Thr 
                85                  90                  95      

Phe His Asn Lys Ala Glu Lys Asp Ala Gln Asn Ile Ile Lys Ser Tyr 
            100                 105                 110         

Gln Gly Pro Asp His Glu Asn Arg Thr Tyr Leu Trp Glu His Ala Lys 
        115                 120                 125             

Asp Tyr Ser Ala Ser Ala Asn Ile Thr Lys Thr Tyr Arg Asn Ile Glu 
    130                 135                 140                 

Lys Ile Ala Lys Gln Ile Thr Asn Pro Glu Ser Cys Tyr Tyr Gln Asp 
145                 150                 155                 160 

Ser Lys Ala Ile Ala Ile Val Lys Asp Gly Met Ala Phe Met Tyr Glu 
                165                 170                 175     

His Ala Tyr Asn Leu Asp Arg Glu Asn His Gln Thr Thr Gly Lys Glu 
            180                 185                 190         

Asn Lys Glu Asn Trp Trp Val Tyr Glu Ile Gly Thr Pro Arg Ala Ile 
        195                 200                 205             

Asn Asn Thr Leu Ser Leu Met Tyr Pro Tyr Phe Thr Gln Glu Glu Ile 
    210                 215                 220                 

Leu Lys Tyr Thr Ala Pro Ile Glu Lys Phe Val Pro Asp Pro Thr Arg 
225                 230                 235                 240 

Phe Arg Val Arg Ala Ala Asn Phe Ser Pro Phe Glu Ala Asn Ser Gly 
                245                 250                 255     

Asn Leu Ile Asp Met Gly Arg Val Lys Leu Ile Ser Gly Ile Leu Arg 
            260                 265                 270         

Lys Asp Asp Leu Glu Ile Ser Asp Thr Ile Lys Ala Ile Glu Lys Val 
        275                 280                 285             

Phe Thr Leu Val Asp Glu Gly Asn Gly Phe Tyr Gln Asp Gly Ser Leu 
    290                 295                 300                 

Ile Asp His Val Val Thr Asn Ala Gln Ser Pro Leu Tyr Lys Lys Gly 
305                 310                 315                 320 

Ile Ala Tyr Thr Gly Ala Tyr Gly Asn Val Leu Ile Asp Gly Leu Ser 
                325                 330                 335     

Gln Leu Ile Pro Ile Ile Gln Lys Thr Lys Ser Pro Ile Lys Ala Asp 
            340                 345                 350         

Lys Met Ala Thr Ile Tyr His Trp Ile Asn His Ser Phe Phe Pro Ile 
        355                 360                 365             

Ile Val Arg Gly Glu Met Met Asp Met Thr Arg Gly Arg Ser Ile Ser 
    370                 375                 380                 

Arg Phe Asn Ala Gln Ser His Val Ala Gly Ile Glu Ala Leu Arg Ala 
385                 390                 395                 400 

Ile Leu Arg Ile Ala Asp Met Ser Glu Glu Pro His Arg Leu Ala Leu 
                405                 410                 415     

Lys Thr Arg Ile Lys Thr Leu Val Thr Gln Gly Asn Ala Phe Tyr Asn 
            420                 425                 430         

Val Tyr Asp Asn Leu Lys Thr Tyr His Asp Ile Lys Leu Met Lys Glu 
        435                 440                 445             

Leu Leu Ser Asp Thr Ser Val Pro Val Gln Lys Leu Asp Ser Tyr Val 
    450                 455                 460                 

Ala Ser Phe Asn Ser Met Asp Lys Leu Ala Leu Tyr Asn Asn Lys His 
465                 470                 475                 480 

Asp Phe Ala Phe Gly Leu Ser Met Phe Ser Asn Arg Thr Gln Asn Tyr 
                485                 490                 495     

Glu Ala Met Asn Asn Glu Asn Leu His Gly Trp Phe Thr Ser Asp Gly 
            500                 505                 510         

Met Phe Tyr Leu Tyr Asn Asn Asp Leu Gly His Tyr Ser Glu Asn Tyr 
        515                 520                 525             

Trp Ala Thr Val Asn Pro Tyr Arg Leu Pro Gly Thr Thr Glu Thr Glu 
    530                 535                 540                 

Gln Lys Pro Leu Glu Gly Thr Pro Glu Asn Ile Lys Thr Asn Tyr Gln 
545                 550                 555                 560 

Gln Val Gly Met Thr Gly Leu Ser Asp Asp Ala Phe Val Ala Ser Lys 
                565                 570                 575     

Lys Leu Asn Asn Thr Ser Ala Leu Ala Ala Met Thr Phe Thr Asn Trp 
            580                 585                 590         

Asn Lys Ser Leu Thr Leu Asn Lys Gly Trp Phe Ile Leu Gly Asn Lys 
        595                 600                 605             

Ile Ile Phe Val Gly Ser Asn Ile Lys Asn Gln Ser Ser His Lys Ala 
    610                 615                 620                 

Tyr Thr Thr Ile Glu Gln Arg Lys Glu Asn Gln Lys Tyr Pro Tyr Cys 
625                 630                 635                 640 

Ser Tyr Val Asn Asn Gln Pro Val Asp Leu Asn Asn Gln Leu Val Asp 
                645                 650                 655     

Phe Thr Asn Thr Lys Ser Ile Phe Leu Glu Ser Asp Asp Pro Ala Gln 
            660                 665                 670         

Asn Ile Gly Tyr Tyr Phe Phe Lys Pro Thr Thr Leu Ser Ile Ser Lys 
        675                 680                 685             

Ala Leu Gln Thr Gly Lys Trp Gln Asn Ile Lys Ala Asp Asp Lys Ser 
    690                 695                 700                 

Pro Glu Ala Ile Lys Glu Val Ser Asn Thr Phe Ile Thr Ile Met Gln 
705                 710                 715                 720 

Asn His Thr Gln Asp Gly Asp Arg Tyr Ala Tyr Met Met Leu Pro Asn 
                725                 730                 735     

Met Thr Arg Gln Glu Phe Glu Thr Tyr Ile Ser Lys Leu Asp Ile Asp 
            740                 745                 750         

Leu Leu Glu Asn Asn Asp Lys Leu Ala Ala Val Tyr Asp His Asp Ser 
        755                 760                 765             

Gln Gln Met His Val Ile His Tyr Gly Lys Lys Ala Thr Met Phe Ser 
    770                 775                 780                 

Asn His Asn Leu Ser His Gln Gly Phe Tyr Ser Phe Pro His Pro Val 
785                 790                 795                 800 

Arg Gln Asn Gln Gln 
                805 

<210>   18
<211>   318
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (28)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   18
Met Lys Arg Phe Leu Asn Ser Arg Pro Trp Leu Gly Met Val Ser Val 
1               5                   10                  15      

Phe Phe Ala Ile Leu Leu Phe Leu Thr Ala Ala Ser Ser Asn His Asn 
            20                  25                  30          

Asn Ser Ser Ser Gln Ile Tyr Ser Pro Ile Glu Thr Tyr Thr His Ser 
        35                  40                  45              

Leu Lys Asp Val Pro Ile Asp Met Lys Tyr Asp Ser Asp Lys Tyr Phe 
    50                  55                  60                  

Ile Ser Gly Tyr Ser Tyr Gly Ala Glu Val Tyr Leu Thr Ser Thr Asn 
65                  70                  75                  80  

Arg Ile Lys Leu Asp Ser Glu Val Asn Asn Asp Thr Arg Asn Phe Lys 
                85                  90                  95      

Ile Val Ala Asp Leu Thr His Ser His Pro Gly Thr Val Ser Val Asn 
            100                 105                 110         

Leu Arg Val Glu Asn Leu Pro Ser Gly Val Thr Ala Thr Val Ser Pro 
        115                 120                 125             

Asp Lys Ile Ser Val Thr Ile Gly Lys Lys Glu Ser Lys Val Phe Pro 
    130                 135                 140                 

Val Arg Gly Ser Val Asp Ala Lys Gln Ile Ala Asn Gly Tyr Glu Ile 
145                 150                 155                 160 

Ser Lys Ile Glu Thr Gly Val Asn Lys Val Glu Val Thr Ser Asp Glu 
                165                 170                 175     

Ser Thr Ile Ala Leu Ile Asp His Val Val Ala Lys Leu Pro Asp Asp 
            180                 185                 190         

Gln Val Leu Asp Arg Asn Tyr Ser Ser Arg Val Thr Leu Gln Ala Val 
        195                 200                 205             

Ser Ala Asp Gly Thr Ile Leu Ala Ser Ala Ile Asp Pro Ala Lys Thr 
    210                 215                 220                 

Asn Leu Ser Val Ala Val Lys Lys Ile Thr Lys Ser Val Pro Ile Arg 
225                 230                 235                 240 

Val Glu Ala Val Gly Met Met Asp Asp Ser Leu Ser Asp Ile Gln Tyr 
                245                 250                 255     

Lys Leu Ser Lys Gln Thr Ala Val Ile Ser Gly Ser Arg Glu Val Leu 
            260                 265                 270         

Glu Asp Ile Asp Glu Ile Ile Ala Glu Val Asn Ile Ser Asp Val Thr 
        275                 280                 285             

Lys Asn Thr Ser Lys Thr Val Ser Leu Ser Ser Ser Gln Val Ser Ile 
    290                 295                 300                 

Glu Pro Ser Val Val Thr Val Gln Leu Thr Thr Thr Lys Lys 
305                 310                 315             

<210>   19
<211>   293
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (9)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (259) ... (293)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   19
Met Leu Thr Phe Gly Gly Ala Ser Ala Val Lys Ala Glu Glu Asn Glu 
1               5                   10                  15      

Lys Val Arg Glu Gln Glu Lys Leu Ile Gln Gln Leu Ser Glu Lys Leu 
            20                  25                  30          

Val Glu Ile Asn Asp Leu Gln Thr Leu Asn Gly Asp Lys Glu Ser Ile 
        35                  40                  45              

Gln Ser Leu Val Asp Tyr Leu Thr Arg Arg Gly Lys Leu Glu Glu Glu 
    50                  55                  60                  

Trp Met Glu Tyr Leu Asn Ser Gly Ile Gln Arg Lys Leu Phe Val Gly 
65                  70                  75                  80  

Pro Lys Gly Pro Ala Gly Glu Lys Gly Glu Gln Gly Pro Thr Gly Lys 
                85                  90                  95      

Gln Gly Glu Arg Gly Glu Thr Gly Pro Ala Gly Pro Arg Gly Asp Lys 
            100                 105                 110         

Gly Glu Thr Gly Asp Lys Gly Ala Gln Gly Pro Val Gly Pro Ala Gly 
        115                 120                 125             

Lys Asp Gly Gln Asn Gly Lys Asp Gly Leu Pro Gly Lys Asp Gly Lys 
    130                 135                 140                 

Asp Gly Gln Asn Gly Lys Asp Gly Leu Pro Gly Lys Asp Gly Lys Asp 
145                 150                 155                 160 

Gly Gln Asp Gly Lys Asp Gly Leu Pro Gly Lys Asp Gly Lys Asp Gly 
                165                 170                 175     

Gln Asn Gly Lys Asp Gly Leu Pro Gly Lys Asp Gly Gln Pro Gly Lys 
            180                 185                 190         

Pro Ala Pro Lys Thr Pro Glu Val Pro Gln Asn Pro Asp Thr Ala Pro 
        195                 200                 205             

His Thr Pro Lys Thr Pro Arg Ile Pro Gly Gln Ser Lys Asp Val Thr 
    210                 215                 220                 

Pro Ala Pro Gln Asn Pro Ser Asn Arg Gly Leu Asn Lys Pro Gln Thr 
225                 230                 235                 240 

Gln Gly Gly Asn Gln Leu Ala Lys Thr Pro Ala Ala His Asp Thr His 
                245                 250                 255     

Arg Gln Leu Pro Ala Thr Gly Glu Thr Thr Asn Pro Phe Phe Thr Ala 
            260                 265                 270         

Ala Ala Val Ala Ile Met Thr Thr Ala Gly Val Val Ala Val Ala Lys 
        275                 280                 285             

Arg Gln Glu Asn Asn 
    290             

<210>   20
<211>   792
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (22)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   20
Met Lys Thr Lys Lys Val Ile Ile Leu Val Gly Leu Leu Leu Ser Ser 
1               5                   10                  15      

Gln Leu Thr Leu Ile Ala Cys Gln Ser Arg Gly Asn Gly Thr Tyr Pro 
            20                  25                  30          

Ile Lys Thr Lys Gln Ser Arg Lys Gly Met Thr Ser Asn Lys Ile Lys 
        35                  40                  45              

Pro Ile Lys Lys Ser Lys Lys Thr Asn Lys Thr His Lys Gly Val Ala 
    50                  55                  60                  

Gly Val Asp Phe Pro Thr Asp Asp Gly Phe Ile Leu Thr Lys Asp Ser 
65                  70                  75                  80  

Lys Ile Leu Ser Lys Thr Asp Gln Gly Ile Val Val Asp His Asp Gly 
                85                  90                  95      

His Ser His Phe Ile Phe Tyr Ala Asp Leu Lys Gly Ser Pro Phe Glu 
            100                 105                 110         

Tyr Leu Ile Pro Lys Gly Ala Ser Leu Ala Lys Pro Ala Val Ala Gln 
        115                 120                 125             

Arg Ala Ala Ser Gln Gly Thr Ser Lys Val Ala Asp Pro His His His 
    130                 135                 140                 

Tyr Glu Phe Asn Pro Ala Asp Ile Val Ala Glu Asp Ala Leu Gly Tyr 
145                 150                 155                 160 

Thr Val Arg His Asp Asp His Phe His Tyr Ile Leu Lys Ser Ser Leu 
                165                 170                 175     

Ser Gly Gln Thr Gln Ala Gln Ala Lys Gln Val Ala Thr Arg Leu Pro 
            180                 185                 190         

Gln Thr Ser Ser Leu Val Ser Thr Ala Thr Ala Asn Gly Ile Pro Gly 
        195                 200                 205             

Leu His Phe Pro Thr Ser Asp Gly Phe Gln Phe Asn Gly Gln Gly Ile 
    210                 215                 220                 

Val Gly Val Thr Lys Asp Ser Ile Leu Val Asp His Asp Gly His Leu 
225                 230                 235                 240 

His Pro Ile Ser Phe Ala Asp Leu Arg Gln Gly Gly Trp Ala His Val 
                245                 250                 255     

Ala Asp Gln Tyr Asp Pro Ala Lys Lys Ala Glu Lys Pro Ala Glu Thr 
            260                 265                 270         

His Gln Thr Pro Glu Leu Ser Glu Arg Glu Lys Glu Tyr Gln Glu Lys 
        275                 280                 285             

Leu Ala Tyr Leu Ala Glu Lys Leu Gly Ile Asp Pro Ser Thr Ile Lys 
    290                 295                 300                 

Arg Val Glu Thr Gln Asp Gly Lys Leu Gly Leu Glu Tyr Pro His His 
305                 310                 315                 320 

Asp His Ala His Val Leu Met Leu Ser Asp Ile Glu Ile Gly Lys Asp 
                325                 330                 335     

Ile Pro Asp Pro His Ala Ile Glu His Ala Arg Glu Leu Glu Lys His 
            340                 345                 350         

Lys Val Gly Met Asp Thr Leu Arg Ala Leu Gly Phe Asp Glu Glu Val 
        355                 360                 365             

Ile Leu Asp Ile Val Arg Thr His Asp Ala Pro Thr Pro Phe Pro Ser 
    370                 375                 380                 

Asn Glu Lys Asp Pro Asn Met Met Lys Glu Trp Leu Ala Thr Val Ile 
385                 390                 395                 400 

Lys Leu Asp Leu Gly Ser Arg Lys Asp Pro Leu Gln Arg Lys Gly Leu 
                405                 410                 415     

Ser Leu Leu Pro Asn Leu Glu Thr Leu Gly Ile Gly Phe Thr Pro Ile 
            420                 425                 430         

Lys Asp Ile Ser Pro Val Leu Gln Phe Lys Lys Leu Lys Gln Leu Leu 
        435                 440                 445             

Met Thr Lys Thr Gly Val Thr Asp Tyr Arg Phe Leu Asp Asn Met Pro 
    450                 455                 460                 

Gln Leu Glu Gly Ile Asp Ile Ser Gln Asn Asn Leu Lys Asp Ile Ser 
465                 470                 475                 480 

Phe Leu Ser Lys Tyr Lys Asn Leu Thr Leu Val Ala Ala Ala Asp Asn 
                485                 490                 495     

Gly Ile Glu Asp Ile Arg Pro Leu Gly Gln Leu Pro Asn Leu Lys Phe 
            500                 505                 510         

Leu Val Leu Ser Asn Asn Lys Ile Ser Asp Leu Ser Pro Leu Ala Ser 
        515                 520                 525             

Leu His Gln Leu Gln Glu Leu His Ile Asp Asn Asn Gln Ile Thr Asp 
    530                 535                 540                 

Leu Ser Pro Val Ser His Lys Glu Ser Leu Thr Val Val Asp Leu Ser 
545                 550                 555                 560 

Arg Asn Ala Asp Val Asp Leu Ala Thr Leu Gln Ala Pro Lys Leu Glu 
                565                 570                 575     

Thr Leu Met Val Asn Asp Thr Lys Val Ser His Leu Asp Phe Leu Lys 
            580                 585                 590         

Asn Asn Pro Asn Leu Ser Ser Leu Ser Ile Asn Arg Ala Gln Leu Gln 
        595                 600                 605             

Ser Leu Glu Gly Ile Glu Ala Ser Ser Val Ile Val Arg Val Glu Ala 
    610                 615                 620                 

Glu Gly Asn Gln Ile Lys Ser Leu Val Leu Lys Asp Lys Gln Gly Ser 
625                 630                 635                 640 

Leu Thr Phe Leu Asp Val Thr Gly Asn Gln Leu Thr Ser Leu Glu Gly 
                645                 650                 655     

Val Asn Asn Phe Thr Ala Leu Asp Ile Leu Ser Val Ser Lys Asn Gln 
            660                 665                 670         

Leu Thr Asn Val Asn Leu Ser Lys Pro Asn Lys Thr Val Thr Asn Ile 
        675                 680                 685             

Asp Ile Ser His Asn Asn Ile Ser Leu Ala Asp Leu Lys Leu Asn Glu 
    690                 695                 700                 

Gln His Ile Pro Glu Ala Ile Ala Lys Asn Phe Pro Ala Val Tyr Glu 
705                 710                 715                 720 

Gly Ser Met Val Gly Asn Gly Thr Ala Glu Glu Lys Ala Ala Met Ala 
                725                 730                 735     

Thr Lys Ala Lys Glu Ser Ala Gln Glu Ala Ser Glu Ser His Asp Tyr 
            740                 745                 750         

Asn His Asn His Thr Tyr Glu Asp Glu Glu Gly His Ala His Glu His 
        755                 760                 765             

Arg Asp Lys Asp Asp His Asp His Glu His Glu Asp Glu Asn Glu Ala 
    770                 775                 780                 

Lys Asp Glu Gln Asn His Ala Asp 
785                 790         

<210>   21
<211>   351
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (22)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   21
Met Lys Asn Ser Asn Lys Leu Ile Ala Ser Val Val Thr Leu Ala Ser 
1               5                   10                  15      

Val Met Ala Leu Ala Ala Cys Gln Ser Thr Asn Asp Asn Thr Lys Val 
            20                  25                  30          

Ile Ser Met Lys Gly Asp Thr Ile Ser Val Ser Asp Phe Tyr Asn Glu 
        35                  40                  45              

Thr Lys Asn Thr Glu Val Ser Gln Lys Ala Met Leu Asn Leu Val Ile 
    50                  55                  60                  

Ser Arg Val Phe Glu Ala Gln Tyr Gly Asp Lys Val Ser Lys Lys Glu 
65                  70                  75                  80  

Val Glu Lys Ala Tyr His Lys Thr Ala Glu Gln Tyr Gly Ala Ser Phe 
                85                  90                  95      

Ser Ala Ala Leu Ala Gln Ser Ser Leu Thr Pro Glu Thr Phe Lys Arg 
            100                 105                 110         

Gln Ile Arg Ser Ser Lys Leu Val Glu Tyr Ala Val Lys Glu Ala Ala 
        115                 120                 125             

Lys Lys Glu Leu Thr Thr Gln Glu Tyr Lys Lys Ala Tyr Glu Ser Tyr 
    130                 135                 140                 

Thr Pro Thr Met Ala Val Glu Met Ile Thr Leu Asp Asn Glu Glu Thr 
145                 150                 155                 160 

Ala Lys Ser Val Leu Glu Glu Leu Lys Ala Glu Gly Ala Asp Phe Thr 
                165                 170                 175     

Ala Ile Ala Lys Glu Lys Thr Thr Thr Pro Glu Lys Lys Val Thr Tyr 
            180                 185                 190         

Lys Phe Asp Ser Gly Ala Thr Asn Val Pro Thr Asp Val Val Lys Ala 
        195                 200                 205             

Ala Ser Ser Leu Asn Glu Gly Gly Ile Ser Asp Val Ile Ser Val Leu 
    210                 215                 220                 

Asp Pro Thr Ser Tyr Gln Lys Lys Phe Tyr Ile Val Lys Val Thr Lys 
225                 230                 235                 240 

Lys Ala Glu Lys Lys Ser Asp Trp Gln Glu Tyr Lys Lys Arg Leu Lys 
                245                 250                 255     

Ala Ile Ile Ile Ala Glu Lys Ser Lys Asp Met Asn Phe Gln Asn Lys 
            260                 265                 270         

Val Ile Ala Asn Ala Leu Asp Lys Ala Asn Val Lys Ile Lys Asp Lys 
        275                 280                 285             

Ala Phe Ala Asn Ile Leu Ala Gln Tyr Ala Asn Leu Gly Gln Lys Thr 
    290                 295                 300                 

Lys Ala Ala Ser Glu Ser Ser Thr Thr Ser Glu Ser Ser Lys Ala Ala 
305                 310                 315                 320 

Glu Glu Asn Pro Ser Glu Ser Glu Gln Thr Gln Thr Ser Ser Ala Glu 
                325                 330                 335     

Glu Pro Thr Glu Thr Glu Ala Gln Thr Gln Glu Pro Ala Ala Gln 
            340                 345                 350     

<210>   22
<211>   424
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (33)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   22
Met Lys Ile Gly Lys Lys Ile Val Leu Met Phe Thr Ala Ile Val Leu 
1               5                   10                  15      

Thr Thr Val Leu Ala Leu Gly Val Tyr Leu Thr Ser Ala Tyr Thr Phe 
            20                  25                  30          

Ser Thr Gly Glu Leu Ser Lys Thr Phe Lys Asp Phe Ser Thr Ser Ser 
        35                  40                  45              

Asn Lys Ser Asp Ala Ile Lys Gln Thr Arg Ala Phe Ser Ile Leu Leu 
    50                  55                  60                  

Met Gly Val Asp Thr Gly Ser Ser Glu Arg Ala Ser Lys Trp Glu Gly 
65                  70                  75                  80  

Asn Ser Asp Ser Met Ile Leu Val Thr Val Asn Pro Lys Thr Lys Lys 
                85                  90                  95      

Thr Thr Met Thr Ser Leu Glu Arg Asp Thr Leu Thr Thr Leu Ser Gly 
            100                 105                 110         

Pro Lys Asn Asn Glu Met Asn Gly Val Glu Ala Lys Leu Asn Ala Ala 
        115                 120                 125             

Tyr Ala Ala Gly Gly Ala Gln Met Ala Ile Met Thr Val Gln Asp Leu 
    130                 135                 140                 

Leu Asn Ile Thr Ile Asp Asn Tyr Val Gln Ile Asn Met Gln Gly Leu 
145                 150                 155                 160 

Ile Asp Leu Val Asn Ala Val Gly Gly Ile Thr Val Thr Asn Glu Phe 
                165                 170                 175     

Asp Phe Pro Ile Ser Ile Ala Glu Asn Glu Pro Glu Tyr Gln Ala Thr 
            180                 185                 190         

Val Ala Pro Gly Thr His Lys Ile Asn Gly Glu Gln Ala Leu Val Tyr 
        195                 200                 205             

Ala Arg Met Arg Tyr Asp Asp Pro Glu Gly Asp Tyr Gly Arg Gln Lys 
    210                 215                 220                 

Arg Gln Arg Glu Val Ile Gln Lys Val Leu Lys Lys Ile Leu Ala Leu 
225                 230                 235                 240 

Asp Ser Ile Ser Ser Tyr Arg Lys Ile Leu Ser Ala Val Ser Ser Asn 
                245                 250                 255     

Met Gln Thr Asn Ile Glu Ile Ser Ser Arg Thr Ile Pro Ser Leu Leu 
            260                 265                 270         

Gly Tyr Arg Asp Ala Leu Arg Thr Ile Lys Thr Tyr Gln Leu Lys Gly 
        275                 280                 285             

Glu Asp Ala Thr Leu Ser Asp Gly Gly Ser Tyr Gln Ile Val Thr Ser 
    290                 295                 300                 

Asn His Leu Leu Glu Ile Gln Asn Arg Ile Arg Thr Glu Leu Gly Leu 
305                 310                 315                 320 

His Lys Val Asn Gln Leu Lys Thr Asn Ala Thr Val Tyr Glu Asn Leu 
                325                 330                 335     

Tyr Gly Ser Thr Lys Ser Gln Thr Val Asn Asn Asn Tyr Asp Ser Ser 
            340                 345                 350         

Gly Gln Ala Pro Ser Tyr Ser Asp Ser His Ser Ser Tyr Ala Asn Tyr 
        355                 360                 365             

Ser Ser Gly Val Asp Thr Gly Gln Ser Ala Ser Thr Asp Gln Asp Ser 
    370                 375                 380                 

Thr Ala Ser Ser His Arg Pro Ala Thr Pro Ser Ser Ser Ser Asp Ala 
385                 390                 395                 400 

Leu Ala Ala Asp Glu Ser Ser Ser Ser Gly Ser Gly Ser Leu Val Pro 
                405                 410                 415     

Pro Ala Asn Ile Asn Pro Gln Thr 
            420                 

<210>   23
<211>   294
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (19)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   23
Met Ile Lys Arg Cys Lys Gly Ile Gly Leu Ala Leu Met Ala Phe Phe 
1               5                   10                  15      

Leu Val Ala Cys Val Asn Gln His Pro Lys Thr Ala Lys Glu Thr Glu 
            20                  25                  30          

Gln Gln Arg Ile Val Ala Thr Ser Val Ala Val Val Asp Ile Cys Asp 
        35                  40                  45              

Arg Leu Asn Leu Asp Leu Val Gly Val Cys Asp Ser Lys Leu Tyr Thr 
    50                  55                  60                  

Leu Pro Lys Arg Tyr Asp Ala Val Lys Arg Val Gly Leu Pro Met Asn 
65                  70                  75                  80  

Pro Asp Ile Glu Leu Ile Ala Ser Leu Lys Pro Thr Trp Ile Leu Ser 
                85                  90                  95      

Pro Asn Ser Leu Gln Glu Asp Leu Glu Pro Lys Tyr Gln Lys Leu Asp 
            100                 105                 110         

Thr Glu Tyr Gly Phe Leu Asn Leu Arg Ser Val Glu Gly Met Tyr Gln 
        115                 120                 125             

Ser Ile Asp Asp Leu Gly Asn Leu Phe Gln Arg Gln Gln Glu Ala Lys 
    130                 135                 140                 

Glu Leu Arg Gln Gln Tyr Gln Asp Tyr Tyr Arg Ala Phe Gln Ala Lys 
145                 150                 155                 160 

Arg Lys Gly Lys Lys Lys Pro Lys Val Leu Ile Leu Met Gly Leu Pro 
                165                 170                 175     

Gly Ser Tyr Leu Val Ala Thr Asn Gln Ser Tyr Val Gly Asn Leu Leu 
            180                 185                 190         

Asp Leu Ala Gly Gly Glu Asn Val Tyr Gln Ser Asp Glu Lys Glu Phe 
        195                 200                 205             

Leu Ser Ala Asn Pro Glu Asp Met Leu Ala Lys Glu Pro Asp Leu Ile 
    210                 215                 220                 

Leu Arg Thr Ala His Ala Ile Pro Asp Lys Val Lys Val Met Phe Asp 
225                 230                 235                 240 

Lys Glu Phe Ala Glu Asn Asp Ile Trp Lys His Phe Thr Ala Val Lys 
                245                 250                 255     

Glu Gly Lys Val Tyr Asp Leu Asp Asn Thr Leu Phe Gly Met Ser Ala 
            260                 265                 270         

Lys Leu Asn Tyr Pro Glu Ala Leu Asp Thr Leu Thr Gln Leu Phe Asp 
        275                 280                 285             

His Val Gly Asp His Pro 
    290                 

<210>   24
<211>   503
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (22)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   24
Met Asn Lys Asn Lys Leu Leu Arg Val Ala Met Leu Leu Ser Leu Leu 
1               5                   10                  15      

Ala Pro Thr Ala Glu Ser Met Thr Val Leu Ala Gln Asp Val Met Leu 
            20                  25                  30          

Glu Thr His Lys Ala Thr Thr Asn Glu Thr Ser Asp Ser Ser Ser Lys 
        35                  40                  45              

Glu Glu Asn Asn Lys Asn Ala Ala Pro Thr Thr Ser Asp Lys Thr Asp 
    50                  55                  60                  

Gln Gly Pro Leu Asp Ala Ser Ala Glu Thr Asn Ser Asn Ser Leu Val 
65                  70                  75                  80  

Asn Ala Asp Asp Lys Lys Arg Ser Asp Ser Ser Gln Ser Ala Ile Gly 
                85                  90                  95      

Ser Ser Asp Asn Lys Ala Glu Ala Glu Asn Gln Val Asp Asp Lys Ser 
            100                 105                 110         

Thr Asp His Ser Lys Ser Thr Asp His Ser Lys Pro Thr Asp Gln Pro 
        115                 120                 125             

Lys Pro Ser Pro Ser Lys Val Asp Thr Ala Pro Ala Ser Ser Leu Ser 
    130                 135                 140                 

Lys Gln Leu Pro Glu Ala Arg Thr Pro Ile Gln Ser Leu Ser Pro Tyr 
145                 150                 155                 160 

Val Ser Asp Leu Asp Leu Ser Glu Ile Asp Ile Pro Ser Val Asn Thr 
                165                 170                 175     

Tyr Ala Ala Tyr Val Glu His Trp Ser Gly Lys Asn Ala Tyr Thr His 
            180                 185                 190         

His Leu Leu Ser Arg Arg Tyr Gly Ile Lys Ala Asp Gln Ile Asp Ser 
        195                 200                 205             

Tyr Leu Lys Ser Thr Gly Ile Ala Tyr Asp Ser Thr Arg Ile Asn Gly 
    210                 215                 220                 

Glu Lys Leu Leu Gln Trp Glu Lys Lys Ser Gly Leu Asp Val Arg Ala 
225                 230                 235                 240 

Ile Val Ala Ile Ala Met Ser Glu Ser Ser Leu Gly Thr Gln Gly Ile 
                245                 250                 255     

Ala Thr Leu Leu Gly Ala Asn Met Phe Gly Tyr Ala Ala Phe Asp Leu 
            260                 265                 270         

Asp Pro Thr Gln Ala Ser Lys Phe Asn Asp Asp Ser Ala Ile Val Lys 
        275                 280                 285             

Met Thr Gln Asp Thr Ile Ile Lys Asn Lys Asn Ser Asn Phe Ala Leu 
    290                 295                 300                 

Gln Asp Leu Lys Ala Ala Lys Phe Ser Arg Gly Gln Leu Asn Phe Ala 
305                 310                 315                 320 

Ser Asp Gly Gly Val Tyr Phe Thr Asp Thr Thr Gly Ser Gly Lys Arg 
                325                 330                 335     

Arg Ala Gln Ile Met Glu Asp Leu Asp Lys Trp Ile Asp Asp His Gly 
            340                 345                 350         

Gly Thr Pro Ala Ile Pro Ala Glu Leu Lys Val Gln Ser Ser Ala Ser 
        355                 360                 365             

Phe Ala Ser Val Pro Ala Gly Tyr Lys Leu Ser Lys Ser Tyr Asp Val 
    370                 375                 380                 

Leu Gly Tyr Gln Ala Ser Ser Tyr Ala Trp Gly Gln Cys Thr Trp Tyr 
385                 390                 395                 400 

Val Tyr Asn Arg Ala Lys Glu Leu Gly Tyr Gln Phe Asp Pro Phe Met 
                405                 410                 415     

Gly Asn Gly Gly Asp Trp Lys Tyr Lys Val Gly Tyr Ala Leu Ser Lys 
            420                 425                 430         

Thr Pro Lys Val Gly Tyr Ala Ile Ser Phe Ala Pro Gly Gln Ala Gly 
        435                 440                 445             

Ala Asp Gly Thr Tyr Gly His Val Ser Ile Val Glu Asp Val Arg Lys 
    450                 455                 460                 

Asp Gly Ser Ile Leu Ile Ser Glu Ser Asn Cys Ile Gly Leu Gly Lys 
465                 470                 475                 480 

Ile Ser Tyr Arg Thr Phe Thr Ala Gln Gln Ala Glu Gln Leu Thr Tyr 
                485                 490                 495     

Val Ile Gly Lys Ser Lys Asn 
            500             

<210>   25
<211>   284
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (21)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   25
Met Lys Ser Lys Lys Val Val Ser Val Ile Ser Leu Thr Leu Ser Leu 
1               5                   10                  15      

Phe Leu Val Thr Gly Cys Ala Lys Val Asp Asn Asn Lys Ser Val Asn 
            20                  25                  30          

Leu Lys Pro Ala Thr Lys Gln Thr Tyr Asn Ser Tyr Ser Asp Asp Gln 
        35                  40                  45              

Leu Arg Ser Arg Glu Asn Thr Met Ser Val Leu Trp Tyr Gln Arg Ala 
    50                  55                  60                  

Ala Glu Thr Gln Ala Leu Tyr Leu Gln Gly Tyr Gln Leu Ala Thr Asp 
65                  70                  75                  80  

Arg Leu Lys Glu Gln Leu Asn Lys Pro Thr Asp Lys Pro Tyr Ser Ile 
                85                  90                  95      

Val Leu Asp Ile Asp Glu Thr Val Leu Asp Asn Ser Pro Tyr Gln Ala 
            100                 105                 110         

Lys Asn Val Leu Glu Gly Thr Gly Phe Thr Pro Glu Ser Trp Asp Tyr 
        115                 120                 125             

Trp Val Gln Lys Lys Glu Ala Lys Pro Val Ala Gly Ala Lys Asp Phe 
    130                 135                 140                 

Leu Gln Phe Ala Asp Gln Asn Gly Val Gln Ile Tyr Tyr Ile Ser Asp 
145                 150                 155                 160 

Arg Ser Thr Thr Gln Val Asp Ala Thr Met Glu Asn Leu Gln Lys Glu 
                165                 170                 175     

Gly Ile Pro Val Gln Gly Arg Asp His Leu Leu Phe Leu Glu Lys Gly 
            180                 185                 190         

Val Lys Ser Lys Glu Ser Arg Arg Gln Lys Val Lys Glu Thr Thr Asn 
        195                 200                 205             

Val Thr Met Leu Phe Gly Asp Asn Leu Leu Asp Phe Ala Asp Phe Ser 
    210                 215                 220                 

Lys Lys Ser Gln Glu Asp Arg Thr Ala Leu Leu Ser Asp Leu Gln Glu 
225                 230                 235                 240 

Glu Phe Gly Arg Arg Phe Ile Ile Phe Pro Asn Pro Met Tyr Gly Ser 
                245                 250                 255     

Trp Glu Gly Ala Ile Tyr Lys Gly Glu Lys Leu Asp Val Leu Lys Gln 
            260                 265                 270         

Leu Glu Glu Arg Arg Lys Ser Leu Lys Ser Phe Lys 
        275                 280                 

<210>   26
<211>   440
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (15)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   26
Met Lys Asn Tyr Leu Ser Ile Gly Val Ile Ala Leu Leu Phe Ala Leu 
1               5                   10                  15      

Thr Phe Gly Thr Val Lys Ser Val Gln Ala Ile Ala Gly Tyr Gly Trp 
            20                  25                  30          

Leu Pro Asp Arg Pro Pro Ile Asn Asn Ser Gln Leu Val Val Ser Met 
        35                  40                  45              

Ala Gly Ile Val Glu Gly Thr Asp Lys Lys Val Phe Ile Asn Phe Phe 
    50                  55                  60                  

Glu Ile Asp Leu Thr Ser Gln Pro Ala His Gly Gly Lys Thr Glu Gln 
65                  70                  75                  80  

Gly Leu Ser Pro Lys Ser Lys Pro Phe Ala Thr Asp Asn Gly Ala Met 
                85                  90                  95      

Pro His Lys Leu Glu Lys Ala Asp Leu Leu Lys Ala Ile Gln Lys Gln 
            100                 105                 110         

Leu Ile Ala Asn Val His Ser Asn Asp Gly Tyr Phe Glu Val Ile Asp 
        115                 120                 125             

Phe Ala Ser Asp Ala Thr Ile Thr Asp Arg Asn Gly Lys Val Tyr Phe 
    130                 135                 140                 

Ala Asp Lys Asp Gly Ser Val Thr Leu Pro Thr Gln Pro Val Gln Glu 
145                 150                 155                 160 

Phe Leu Leu Lys Gly His Val Arg Val Arg Pro Tyr Lys Glu Lys Pro 
                165                 170                 175     

Val Gln Asn Gln Ala Lys Ser Val Asp Val Glu Tyr Thr Val Gln Phe 
            180                 185                 190         

Thr Pro Leu Asn Pro Asp Asp Asp Phe Arg Pro Gly Leu Lys Asp Thr 
        195                 200                 205             

Lys Leu Leu Lys Thr Leu Ala Ile Gly Asp Thr Ile Thr Ser Gln Glu 
    210                 215                 220                 

Leu Leu Ala Gln Ala Gln Ser Ile Leu Asn Lys Thr His Pro Gly Tyr 
225                 230                 235                 240 

Thr Ile Tyr Glu Arg Asp Ser Ser Ile Val Thr His Asp Asn Asp Ile 
                245                 250                 255     

Phe Arg Thr Ile Leu Pro Met Asp Gln Glu Phe Thr Tyr His Val Lys 
            260                 265                 270         

Asn Arg Glu Gln Ala Tyr Glu Ile Asn Pro Lys Thr Gly Ile Lys Glu 
        275                 280                 285             

Lys Thr Asn Asn Thr Asp Leu Val Ser Glu Lys Tyr Tyr Val Leu Lys 
    290                 295                 300                 

Gln Gly Glu Lys Pro Tyr Asp Pro Phe Asp Arg Ser His Leu Lys Leu 
305                 310                 315                 320 

Phe Thr Ile Lys Tyr Val Asp Val Asn Thr Asn Glu Leu Leu Lys Ser 
                325                 330                 335     

Glu Gln Leu Leu Thr Ala Ser Glu Arg Asn Leu Asp Phe Arg Asp Leu 
            340                 345                 350         

Tyr Asp Pro Arg Asp Lys Ala Lys Leu Leu Tyr Asn Asn Leu Asp Ala 
        355                 360                 365             

Phe Asp Ile Met Asp Tyr Thr Leu Thr Gly Lys Val Glu Asp Asn His 
    370                 375                 380                 

Asp Lys Asn Asn Arg Val Val Thr Val Tyr Met Gly Lys Arg Pro Lys 
385                 390                 395                 400 

Gly Ala Lys Gly Ser Tyr His Leu Ala Tyr Asp Lys Asp Leu Tyr Thr 
                405                 410                 415     

Glu Glu Glu Arg Lys Ala Tyr Ser Tyr Leu Arg Asp Thr Gly Thr Pro 
            420                 425                 430         

Ile Pro Asp Asn Pro Lys Asp Lys 
        435                 440 

<210>   27
<211>   542
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (22)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   27
Met Ser Lys Tyr Leu Lys Tyr Phe Ser Ile Ile Thr Leu Phe Leu Thr 
1               5                   10                  15      

Gly Leu Ile Leu Val Ala Cys Gln Gln Gln Lys Pro Gln Thr Lys Glu 
            20                  25                  30          

Arg Gln Arg Lys Gln Arg Pro Lys Asp Glu Leu Val Val Ser Met Gly 
        35                  40                  45              

Ala Lys Leu Pro His Glu Phe Asp Pro Lys Asp Arg Tyr Gly Val His 
    50                  55                  60                  

Asn Glu Gly Asn Ile Thr His Ser Thr Leu Leu Lys Arg Ser Pro Glu 
65                  70                  75                  80  

Leu Asp Ile Lys Gly Glu Leu Ala Lys Thr Tyr His Leu Ser Glu Asp 
                85                  90                  95      

Gly Leu Thr Trp Ser Phe Asp Leu His Asp Asp Phe Lys Phe Ser Asn 
            100                 105                 110         

Gly Glu Pro Val Thr Ala Asp Asp Val Lys Phe Thr Tyr Asp Met Leu 
        115                 120                 125             

Lys Ala Asp Gly Lys Ala Trp Asp Leu Thr Phe Ile Lys Asn Val Glu 
    130                 135                 140                 

Val Val Gly Lys Asn Gln Val Asn Ile His Leu Thr Glu Ala His Ser 
145                 150                 155                 160 

Thr Phe Thr Ala Gln Leu Thr Glu Ile Pro Ile Val Pro Lys Lys His 
                165                 170                 175     

Tyr Asn Asp Lys Tyr Lys Ser Asn Pro Ile Gly Ser Gly Pro Tyr Met 
            180                 185                 190         

Val Lys Glu Tyr Lys Ala Gly Glu Gln Ala Ile Phe Val Arg Asn Pro 
        195                 200                 205             

Tyr Trp His Gly Lys Lys Pro Tyr Phe Lys Lys Trp Thr Trp Val Leu 
    210                 215                 220                 

Leu Asp Glu Asn Thr Ala Leu Ala Ala Leu Glu Ser Gly Asp Val Asp 
225                 230                 235                 240 

Met Ile Tyr Ala Thr Pro Glu Leu Ala Asp Lys Lys Val Lys Gly Thr 
                245                 250                 255     

Arg Leu Leu Asp Ile Pro Ser Asn Asp Val Arg Gly Leu Ser Leu Pro 
            260                 265                 270         

Tyr Val Lys Lys Gly Val Ile Thr Asp Ser Pro Asp Gly Tyr Pro Val 
        275                 280                 285             

Gly Asn Asp Val Thr Ser Asp Pro Ala Ile Arg Lys Ala Leu Thr Ile 
    290                 295                 300                 

Gly Leu Asn Arg Gln Lys Val Leu Asp Thr Val Leu Asn Gly Tyr Gly 
305                 310                 315                 320 

Lys Pro Ala Tyr Ser Ile Ile Asp Lys Thr Pro Phe Trp Asn Pro Lys 
                325                 330                 335     

Thr Ala Ile Lys Asp Asn Lys Val Ala Lys Ala Lys Gln Leu Leu Thr 
            340                 345                 350         

Lys Ala Gly Trp Lys Glu Gln Ala Asp Gly Ser Arg Lys Lys Gly Asp 
        355                 360                 365             

Leu Asp Ala Ala Phe Asp Leu Tyr Tyr Pro Thr Asn Asp Gln Leu Arg 
    370                 375                 380                 

Ala Asn Leu Ala Val Glu Val Ala Glu Gln Ala Lys Ala Leu Gly Ile 
385                 390                 395                 400 

Thr Ile Lys Leu Lys Ala Ser Asn Trp Asp Glu Met Ala Thr Lys Ser 
                405                 410                 415     

His Asp Ser Ala Leu Leu Tyr Ala Gly Gly Arg His His Ala Gln Gln 
            420                 425                 430         

Phe Tyr Glu Ser His His Pro Ser Leu Ala Gly Lys Gly Trp Thr Asn 
        435                 440                 445             

Ile Thr Phe Tyr Asn Asn Pro Thr Val Thr Lys Tyr Leu Asp Lys Ala 
    450                 455                 460                 

Met Thr Ser Ser Asp Leu Asp Lys Ala Asn Glu Tyr Trp Lys Leu Ala 
465                 470                 475                 480 

Gln Trp Asp Gly Lys Thr Gly Ala Ser Thr Leu Gly Asp Leu Pro Asn 
                485                 490                 495     

Val Trp Leu Val Ser Leu Asn His Thr Tyr Ile Gly Asp Lys Arg Ile 
            500                 505                 510         

Asn Val Gly Lys Gln Gly Val His Ser His Gly His Asp Trp Ser Leu 
        515                 520                 525             

Leu Thr Asn Ile Ala Glu Trp Thr Trp Asp Glu Ser Thr Lys 
    530                 535                 540         

<210>   28
<211>   306
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (19)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   28
Met Lys Lys Gly Phe Phe Leu Met Ala Met Val Val Ser Leu Val Met 
1               5                   10                  15      

Ile Ala Gly Cys Asp Lys Ser Ala Asn Pro Lys Gln Pro Thr Gln Gly 
            20                  25                  30          

Met Ser Val Val Thr Ser Phe Tyr Pro Met Tyr Ala Met Thr Lys Glu 
        35                  40                  45              

Val Ser Gly Asp Leu Asn Asp Val Arg Met Ile Gln Ser Gly Ala Gly 
    50                  55                  60                  

Ile His Ser Phe Glu Pro Ser Val Asn Asp Val Ala Ala Ile Tyr Asp 
65                  70                  75                  80  

Ala Asp Leu Phe Val Tyr His Ser His Thr Leu Glu Ala Trp Ala Arg 
                85                  90                  95      

Asp Leu Asp Pro Asn Leu Lys Lys Ser Lys Val Asp Val Phe Glu Ala 
            100                 105                 110         

Ser Lys Pro Leu Thr Leu Asp Arg Val Lys Gly Leu Glu Asp Met Glu 
        115                 120                 125             

Val Thr Gln Gly Ile Asp Pro Ala Thr Leu Tyr Asp Pro His Thr Trp 
    130                 135                 140                 

Thr Asp Pro Val Leu Ala Gly Glu Glu Ala Val Asn Ile Ala Lys Glu 
145                 150                 155                 160 

Leu Gly Arg Leu Asp Pro Lys His Lys Asp Ser Tyr Thr Lys Asn Ala 
                165                 170                 175     

Lys Ala Phe Lys Lys Glu Ala Glu Gln Leu Thr Glu Glu Tyr Thr Gln 
            180                 185                 190         

Lys Phe Lys Lys Val Arg Ser Lys Thr Phe Val Thr Gln His Thr Ala 
        195                 200                 205             

Phe Ser Tyr Leu Ala Lys Arg Phe Gly Leu Lys Gln Leu Gly Ile Ser 
    210                 215                 220                 

Gly Ile Ser Pro Glu Gln Glu Pro Ser Pro Arg Gln Leu Lys Glu Ile 
225                 230                 235                 240 

Gln Asp Phe Val Lys Glu Tyr Asn Val Lys Thr Ile Phe Ala Glu Asp 
                245                 250                 255     

Asn Val Asn Pro Lys Ile Ala His Ala Ile Ala Lys Ser Thr Gly Ala 
            260                 265                 270         

Lys Val Lys Thr Leu Ser Pro Leu Glu Ala Ala Pro Ser Gly Asn Lys 
        275                 280                 285             

Thr Tyr Leu Glu Asn Leu Arg Ala Asn Leu Glu Val Leu Tyr Gln Gln 
    290                 295                 300                 

Leu Lys 
305     

<210>   29
<211>   309
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (22)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   29
Met Lys Gln Met Asn Lys Leu Ile Thr Gly Val Val Thr Leu Ala Thr 
1               5                   10                  15      

Val Val Thr Leu Ser Ala Cys Gln Ser Ser His Asn Asn Thr Lys Leu 
            20                  25                  30          

Val Ser Met Lys Gly Asp Thr Ile Thr Val Ser Asp Phe Tyr Asn Glu 
        35                  40                  45              

Thr Lys Asn Thr Glu Leu Ala Gln Lys Ala Met Leu Ser Leu Val Ile 
    50                  55                  60                  

Ser Arg Val Phe Glu Thr Gln Tyr Ala Asn Lys Val Ser Asp Lys Glu 
65                  70                  75                  80  

Val Glu Lys Ala Tyr Lys Gln Thr Ala Asp Gln Tyr Gly Thr Ser Phe 
                85                  90                  95      

Lys Thr Val Leu Ala Gln Ser Gly Leu Thr Pro Glu Thr Tyr Lys Lys 
            100                 105                 110         

Gln Ile Arg Leu Thr Lys Leu Val Glu Tyr Ala Val Lys Glu Gln Ala 
        115                 120                 125             

Lys Asn Glu Thr Ile Ser Lys Lys Asp Tyr Arg Gln Ala Tyr Asp Ala 
    130                 135                 140                 

Tyr Thr Pro Thr Met Thr Ala Glu Ile Met Gln Phe Glu Lys Glu Glu 
145                 150                 155                 160 

Asp Ala Lys Ala Ala Leu Glu Ala Val Lys Ala Glu Gly Ala Asp Phe 
                165                 170                 175     

Ala Ala Ile Ala Lys Glu Lys Thr Thr Ala Ala Asp Lys Lys Thr Thr 
            180                 185                 190         

Tyr Thr Phe Asp Ser Gly Glu Thr Thr Leu Pro Ala Glu Val Val Arg 
        195                 200                 205             

Ala Ala Ser Gly Leu Lys Glu Gly Asn Arg Ser Glu Ile Ile Thr Ala 
    210                 215                 220                 

Leu Asp Pro Ala Thr Ser Lys Arg Thr Tyr His Ile Ile Lys Val Thr 
225                 230                 235                 240 

Lys Lys Ala Thr Lys Lys Ala Asp Trp Lys Ala Tyr Gln Lys Arg Leu 
                245                 250                 255     

Lys Asp Ile Ile Val Thr Gly Lys Leu Lys Asp Pro Asp Phe Gln Asn 
            260                 265                 270         

Lys Val Ile Ala Lys Ala Leu Asp Lys Ala Asn Val Lys Ile Lys Asp 
        275                 280                 285             

Lys Ala Phe Ala Asn Ile Leu Ala Gln Phe Ala Lys Pro Asn Gln Lys 
    290                 295                 300                 

Gln Pro Ala Gln Lys 
305                 

<210>   30
<211>   498
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (20)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   30
Met Ile Asn Lys Lys Ile Ser Leu Gly Val Leu Ser Ile Leu Thr Ala 
1               5                   10                  15      

Phe Ser Leu Gln Ser Val Ser Tyr Ala Cys Thr Gly Phe Ile Ile Gly 
            20                  25                  30          

Lys Asp Leu Thr Lys Asp Gly Ser Leu Leu Tyr Gly Arg Thr Glu Asp 
        35                  40                  45              

Leu Glu Pro His His Asn Lys Asn Phe Ile Val Arg Leu Ala Lys Asp 
    50                  55                  60                  

Asn Pro Ala Gly Glu Lys Trp Lys Asp Leu Ser Asn Gly Phe Glu Tyr 
65                  70                  75                  80  

Pro Leu Pro Glu His Ser Tyr Arg Tyr Ser Ala Ile Pro Asp Val Thr 
                85                  90                  95      

Pro Asn Lys Gly Val Tyr Asp Glu Ala Gly Phe Asn Glu Phe Gly Val 
            100                 105                 110         

Ser Met Ser Ala Thr Val Ser Ala Ser Ala Asn Asp Ala Ile Gln Lys 
        115                 120                 125             

Ile Asp Pro Tyr Val Lys Asn Gly Leu Ala Glu Ser Ser Met Thr Ser 
    130                 135                 140                 

Val Ile Leu Pro Ser Val Lys Thr Ala Arg Glu Gly Val Ala Leu Ile 
145                 150                 155                 160 

Ala Lys Ile Val Thr Glu Lys Gly Ala Ala Glu Gly Asn Ile Val Thr 
                165                 170                 175     

Leu Ala Asp Lys Asp Gly Ile Trp Tyr Met Glu Ile Leu Ser Gly His 
            180                 185                 190         

Gln Tyr Val Ala Ile Lys Phe Pro Asp Asp Lys Tyr Ala Val Phe Pro 
        195                 200                 205             

Asn Thr Phe Tyr Leu Gly His Val Asp Phe Asn Asp Lys Glu Asn Thr 
    210                 215                 220                 

Ile Ala Ser Glu Asp Val Glu Lys Val Ala Lys Lys Ala Lys Ser Tyr 
225                 230                 235                 240 

Thr Glu Val Asp Gly Lys Phe His Ile Ala Lys Ser Tyr Asn Pro Pro 
                245                 250                 255     

Leu Asn Asp Ala Asn Arg Ser Arg Ser Phe Ser Gly Ile Lys Ser Leu 
            260                 265                 270         

Asp Pro Asp Ser Lys Val Thr Tyr Lys Asp Ser Asn Tyr Glu Leu Leu 
        275                 280                 285             

Gln Ser Thr Asp Lys Thr Phe Ser Leu Glu Asp Ala Met Lys Leu Gln 
    290                 295                 300                 

Arg Asn Arg Phe Glu Gly Leu Asp Leu Lys Pro Leu Asp Gln Met Ala 
305                 310                 315                 320 

Leu Asp Gly Lys Gly Lys Pro Lys Ser Lys Lys Ala Val Lys Gly Tyr 
                325                 330                 335     

Ala Tyr Pro Ile Ser Asn Pro Asn Val Met Glu Ala His Ile Phe Gln 
            340                 345                 350         

Leu Lys Lys Asp Ile Pro Ala Glu Leu Gly Gly Val Met Trp Leu Ser 
        355                 360                 365             

Ile Gly Ser Pro Arg Asn Ala Pro Tyr Leu Pro Tyr Leu Gly Asn Ile 
    370                 375                 380                 

Ser Arg Thr Tyr Glu Ala Tyr Gln Glu Lys Ser Thr Gln Tyr Asn Asp 
385                 390                 395                 400 

Lys Ser Trp Tyr Trp Thr Val Ser His Ile Asn Asp Leu Val Ala Ala 
                405                 410                 415     

His Pro Lys Pro Phe Gly Thr Lys Val Ile Asp Glu Met Lys Gly Leu 
            420                 425                 430         

Glu Lys Thr Trp Ile Ala Glu Gln Asp Lys Ser Thr Lys Glu Ile Ser 
        435                 440                 445             

Asp Leu Val Val Ser Asp Pro Lys Ala Ala Gln Glu Lys Ala Asp Lys 
    450                 455                 460                 

Ile Ser Leu Asp Arg Ala Glu Lys Thr Phe Lys Arg Leu Lys Ala Ile 
465                 470                 475                 480 

Glu Ala Lys Leu Val Lys Glu Lys Pro Lys Asn Lys Lys Gly Leu Asn 
                485                 490                 495     

Arg Ser 
        

<210>   31
<211>   910
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (877) ... (910)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   31
Met Ile Asn Lys Lys Cys Ile Ile Pro Val Ser Leu Leu Thr Leu Ala 
1               5                   10                  15      

Ile Thr Leu Thr Ser Val Glu Glu Val Thr Ser Arg Gln Asn Leu Thr 
            20                  25                  30          

Tyr Ala Asn Glu Ile Val Thr Gln Arg Pro Lys Arg Glu Ser Val Ile 
        35                  40                  45              

Ser Asp Lys Ser Asn Phe Pro Val Ile Ser Pro Tyr Leu Ala Ser Val 
    50                  55                  60                  

Asp Phe Gly Glu Arg Lys Thr Pro Leu Pro Thr Pro Asp Lys Gly Val 
65                  70                  75                  80  

Lys Val Thr Thr Glu Gln Ser Ile Ala Gln Val Arg Lys Gly Pro Glu 
                85                  90                  95      

Glu Arg Pro Tyr Thr Val Thr Gly Lys Ile Thr Ser Val Ile Asn Gly 
            100                 105                 110         

Trp Gly Gly Tyr Gly Phe Tyr Ile Gln Asp Ser Glu Gly Ile Gly Leu 
        115                 120                 125             

Tyr Val Tyr Pro Gln Lys Asp Leu Gly Tyr Ser Lys Gly Asp Ile Val 
    130                 135                 140                 

Gln Leu Thr Gly Thr Leu Thr Arg Phe Lys Gly Asp Leu Gln Leu Gln 
145                 150                 155                 160 

Gln Val Thr Ala His Lys Lys Leu Glu Leu Ser Phe Pro Thr Ser Val 
                165                 170                 175     

Lys Glu Ala Val Ile Ser Glu Leu Glu Thr Thr Thr Pro Ser Thr Leu 
            180                 185                 190         

Val Lys Leu Ser His Val Thr Val Gly Glu Leu Ser Thr Asp Gln Tyr 
        195                 200                 205             

Asn Asn Thr Ser Phe Leu Val Arg Asp Asp Ser Gly Lys Ser Ile Val 
    210                 215                 220                 

Val His Ile Asp His Arg Thr Gly Val Lys Gly Ala Asp Val Val Thr 
225                 230                 235                 240 

Lys Ile Ser Gln Gly Asp Leu Ile Asn Leu Thr Ala Ile Leu Ser Ile 
                245                 250                 255     

Val Asp Gly Gln Leu Gln Leu Arg Pro Phe Ser Leu Glu Gln Leu Glu 
            260                 265                 270         

Val Val Lys Lys Val Thr Ser Ser Asn Ser Asp Ala Ser Ser Arg Asn 
        275                 280                 285             

Ile Val Lys Ile Gly Glu Ile Gln Gly Ala Ser His Thr Ser Pro Leu 
    290                 295                 300                 

Leu Lys Lys Ala Val Thr Val Glu Gln Val Val Val Thr Tyr Leu Asp 
305                 310                 315                 320 

Asp Ser Thr His Phe Tyr Val Gln Asp Leu Asn Gly Asp Gly Asp Leu 
                325                 330                 335     

Ala Thr Ser Asp Gly Ile Arg Val Phe Ala Lys Asn Ala Lys Val Gln 
            340                 345                 350         

Val Gly Asp Val Leu Thr Ile Ser Gly Glu Val Glu Glu Phe Phe Gly 
        355                 360                 365             

Arg Gly Tyr Glu Glu Arg Lys Gln Thr Asp Leu Thr Ile Thr Gln Ile 
    370                 375                 380                 

Val Ala Lys Ala Val Thr Lys Thr Gly Thr Ala Gln Val Pro Ser Pro 
385                 390                 395                 400 

Leu Val Leu Gly Lys Asp Arg Ile Ala Pro Ala Asn Ile Ile Asp Asn 
                405                 410                 415     

Asp Gly Leu Arg Val Phe Asp Pro Glu Glu Asp Ala Ile Asp Tyr Trp 
            420                 425                 430         

Glu Ser Met Glu Gly Met Leu Val Ala Val Asp Asp Ala Lys Ile Leu 
        435                 440                 445             

Gly Pro Met Lys Asn Lys Glu Ile Tyr Val Leu Pro Gly Ser Ser Thr 
    450                 455                 460                 

Arg Pro Leu Asn Asn Ser Gly Gly Val Leu Leu Pro Ala Asn Ser Tyr 
465                 470                 475                 480 

Asn Thr Asp Val Ile Pro Val Leu Phe Lys Lys Gly Lys Gln Ile Ile 
                485                 490                 495     

Lys Ala Gly Asp Ser Tyr Lys Gly Arg Leu Ala Gly Pro Val Ser Tyr 
            500                 505                 510         

Ser Tyr Gly Asn Tyr Lys Val Phe Val Asp Asp Ser Lys Asn Met Pro 
        515                 520                 525             

Ser Leu Met Asp Gly His Leu Lys Pro Glu Lys Thr Asn Leu Gln Lys 
    530                 535                 540                 

Asp Leu Ser Lys Leu Ser Ile Ala Ser Tyr Asn Ile Glu Asn Phe Ser 
545                 550                 555                 560 

Ala Asn Pro Ser Ser Thr Lys Asp Glu Lys Val Lys Arg Ile Ala Glu 
                565                 570                 575     

Ser Phe Ile His Asp Leu Asn Ala Pro Asp Ile Ile Gly Leu Ile Glu 
            580                 585                 590         

Val Gln Asp Asn Asn Gly Pro Thr Asp Asp Gly Thr Thr Asp Ala Thr 
        595                 600                 605             

Gln Ser Ala Gln Arg Leu Ile Asp Ala Ile Lys Lys Leu Gly Gly Pro 
    610                 615                 620                 

Thr Tyr Arg Tyr Val Asp Ile Ala Pro Glu Asn Asn Val Asp Gly Gly 
625                 630                 635                 640 

Gln Pro Gly Gly Asn Ile Arg Thr Gly Phe Leu Tyr Gln Pro Glu Arg 
                645                 650                 655     

Val Ser Leu Ser Asp Lys Pro Lys Gly Gly Ala Arg Asp Ala Leu Thr 
            660                 665                 670         

Trp Val Asn Gly Glu Leu Asn Leu Ser Val Gly Arg Ile Asp Pro Thr 
        675                 680                 685             

Asn Ala Ala Trp Lys Asp Val Arg Lys Ser Leu Ala Ala Glu Phe Ile 
    690                 695                 700                 

Phe Gln Gly Arg Lys Val Val Val Val Ala Asn His Leu Asn Ser Lys 
705                 710                 715                 720 

Arg Gly Asp Asn Ala Leu Tyr Gly Cys Val Gln Pro Val Thr Phe Lys 
                725                 730                 735     

Ser Glu Gln Arg Arg His Val Leu Ala Asn Met Leu Ala Gln Phe Ala 
            740                 745                 750         

Lys Glu Gly Ala Lys His Gln Ala Asn Ile Val Met Leu Gly Asp Phe 
        755                 760                 765             

Asn Asp Phe Glu Phe Thr Lys Thr Ile Gln Leu Ile Glu Glu Gly Asp 
    770                 775                 780                 

Met Val Asn Leu Val Ser Arg His Asp Ile Ser Asp Arg Tyr Ser Tyr 
785                 790                 795                 800 

Phe His Gln Gly Asn Asn Gln Thr Leu Asp Asn Ile Leu Val Ser Arg 
                805                 810                 815     

His Leu Leu Asp His Tyr Glu Phe Asp Met Val His Val Asn Ser Pro 
            820                 825                 830         

Phe Met Glu Ala His Gly Arg Ala Ser Asp His Asp Pro Leu Leu Leu 
        835                 840                 845             

Gln Leu Ser Phe Ser Lys Glu Asn Asp Lys Ala Glu Ser Ser Lys Gln 
    850                 855                 860                 

Ser Val Lys Ala Lys Lys Thr Ser Lys Gly Lys Leu Leu Pro Lys Thr 
865                 870                 875                 880 

Gly Asp Ser Leu Val Tyr Val Ile Thr Leu Leu Gly Thr Ala Ser Leu 
                885                 890                 895     

Leu Val Pro Ile Leu Leu Leu Thr Lys Gly Lys Lys Glu Ser 
            900                 905                 910 

<210>   32
<211>   1008
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (21)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (975) ... (1008)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   32
Met Lys Lys His Leu Lys Thr Val Ala Leu Thr Leu Thr Thr Val Ser 
1               5                   10                  15      

Val Val Thr His Asn Gln Glu Val Phe Ser Leu Val Lys Glu Pro Ile 
            20                  25                  30          

Leu Lys Gln Thr Gln Ala Ser Ser Ser Ile Ser Gly Ala Asp Tyr Ala 
        35                  40                  45              

Glu Ser Ser Gly Lys Ser Lys Leu Lys Ile Asn Glu Thr Ser Gly Pro 
    50                  55                  60                  

Val Asp Asp Thr Val Thr Asp Leu Phe Ser Asp Lys Arg Thr Thr Pro 
65                  70                  75                  80  

Glu Lys Ile Lys Asp Asn Leu Ala Lys Gly Pro Arg Glu Gln Glu Leu 
                85                  90                  95      

Lys Ala Val Thr Glu Asn Thr Glu Ser Glu Lys Gln Ile Thr Ser Gly 
            100                 105                 110         

Ser Gln Leu Glu Gln Ser Lys Glu Ser Leu Ser Leu Asn Lys Thr Val 
        115                 120                 125             

Pro Ser Thr Ser Asn Trp Glu Ile Cys Asp Phe Ile Thr Lys Gly Asn 
    130                 135                 140                 

Thr Leu Val Gly Leu Ser Lys Ser Gly Val Glu Lys Leu Ser Gln Thr 
145                 150                 155                 160 

Asp His Leu Val Leu Pro Ser Gln Ala Ala Asp Gly Thr Gln Leu Ile 
                165                 170                 175     

Gln Val Ala Ser Phe Ala Phe Thr Pro Asp Lys Lys Thr Ala Ile Ala 
            180                 185                 190         

Glu Tyr Thr Ser Arg Ala Gly Glu Asn Gly Glu Ile Ser Gln Leu Asp 
        195                 200                 205             

Val Asp Gly Lys Glu Ile Ile Asn Glu Gly Glu Val Phe Asn Ser Tyr 
    210                 215                 220                 

Leu Leu Lys Lys Val Thr Ile Pro Thr Gly Tyr Lys His Ile Gly Gln 
225                 230                 235                 240 

Asp Ala Phe Val Asp Asn Lys Asn Ile Ala Glu Val Asn Leu Pro Glu 
                245                 250                 255     

Ser Leu Glu Thr Ile Ser Asp Tyr Ala Phe Ala His Leu Ala Leu Lys 
            260                 265                 270         

Gln Ile Asp Leu Pro Asp Asn Leu Lys Ala Ile Gly Glu Leu Ala Phe 
        275                 280                 285             

Phe Asp Asn Gln Ile Thr Gly Lys Leu Ser Leu Pro Arg Gln Leu Met 
    290                 295                 300                 

Arg Leu Ala Glu Arg Ala Phe Lys Ser Asn His Ile Lys Thr Ile Glu 
305                 310                 315                 320 

Phe Arg Gly Asn Ser Leu Lys Val Ile Gly Glu Ala Ser Phe Gln Asp 
                325                 330                 335     

Asn Asp Leu Ser Gln Leu Met Leu Pro Asp Gly Leu Glu Lys Ile Glu 
            340                 345                 350         

Ser Glu Ala Phe Thr Gly Asn Pro Gly Asp Asp His Tyr Asn Asn Arg 
        355                 360                 365             

Val Val Leu Trp Thr Lys Ser Gly Lys Asn Pro Ser Gly Leu Ala Thr 
    370                 375                 380                 

Glu Asn Thr Tyr Val Asn Pro Asp Lys Ser Leu Trp Gln Glu Ser Pro 
385                 390                 395                 400 

Glu Ile Asp Tyr Thr Lys Trp Leu Glu Glu Asp Phe Thr Tyr Gln Lys 
                405                 410                 415     

Asn Ser Val Thr Gly Phe Ser Asn Lys Gly Leu Gln Lys Val Lys Arg 
            420                 425                 430         

Asn Lys Asn Leu Glu Ile Pro Lys Gln His Asn Gly Val Thr Ile Thr 
        435                 440                 445             

Glu Ile Gly Asp Asn Ala Phe Arg Asn Val Asp Phe Gln Asn Lys Thr 
    450                 455                 460                 

Leu Arg Lys Tyr Asp Leu Glu Glu Val Lys Leu Pro Ser Thr Ile Arg 
465                 470                 475                 480 

Lys Ile Gly Ala Phe Ala Phe Gln Ser Asn Asn Leu Lys Ser Phe Glu 
                485                 490                 495     

Ala Ser Asp Asp Leu Glu Glu Ile Lys Glu Gly Ala Phe Met Asn Asn 
            500                 505                 510         

Arg Ile Glu Thr Leu Glu Leu Lys Asp Lys Leu Val Thr Ile Gly Asp 
        515                 520                 525             

Ala Ala Phe His Ile Asn His Ile Tyr Ala Ile Val Leu Pro Glu Ser 
    530                 535                 540                 

Val Gln Glu Ile Gly Arg Ser Ala Phe Arg Gln Asn Gly Ala Asn Asn 
545                 550                 555                 560 

Leu Ile Phe Met Gly Ser Lys Val Lys Thr Leu Gly Glu Met Ala Phe 
                565                 570                 575     

Leu Ser Asn Arg Leu Glu His Leu Asp Leu Ser Glu Gln Lys Gln Leu 
            580                 585                 590         

Thr Glu Ile Pro Val Gln Ala Phe Ser Asp Asn Ala Leu Lys Glu Val 
        595                 600                 605             

Leu Leu Pro Ala Ser Leu Lys Thr Ile Arg Glu Glu Ala Phe Lys Lys 
    610                 615                 620                 

Asn His Leu Lys Gln Leu Glu Val Ala Ser Ala Leu Ser His Ile Ala 
625                 630                 635                 640 

Phe Asn Ala Leu Asp Asp Asn Asp Gly Asp Glu Gln Phe Asp Asn Lys 
                645                 650                 655     

Val Val Val Lys Thr His His Asn Ser Tyr Ala Leu Ala Asp Gly Glu 
            660                 665                 670         

His Phe Ile Val Asp Pro Asp Lys Leu Ser Ser Thr Ile Val Asp Leu 
        675                 680                 685             

Glu Lys Ile Leu Lys Leu Ile Glu Gly Leu Asp Tyr Ser Thr Leu Arg 
    690                 695                 700                 

Gln Thr Thr Gln Thr Gln Phe Arg Asp Met Thr Thr Ala Gly Lys Ala 
705                 710                 715                 720 

Leu Leu Ser Lys Ser Asn Leu Arg Gln Gly Glu Lys Gln Lys Phe Leu 
                725                 730                 735     

Gln Glu Ala Gln Phe Phe Leu Gly Arg Val Asp Leu Asp Lys Ala Ile 
            740                 745                 750         

Ala Lys Ala Glu Lys Ala Leu Val Thr Lys Lys Ala Thr Lys Asn Gly 
        755                 760                 765             

Gln Leu Leu Glu Arg Ser Ile Asn Lys Ala Val Leu Ala Tyr Asn Asn 
    770                 775                 780                 

Ser Ala Ile Lys Lys Ala Asn Val Lys Arg Leu Glu Lys Glu Leu Asp 
785                 790                 795                 800 

Leu Leu Thr Gly Leu Val Glu Gly Lys Gly Pro Leu Ala Gln Ala Thr 
                805                 810                 815     

Met Val Gln Gly Val Tyr Leu Leu Lys Thr Pro Leu Pro Leu Pro Glu 
            820                 825                 830         

Tyr Tyr Ile Gly Leu Asn Val Tyr Phe Asp Lys Ser Gly Lys Leu Ile 
        835                 840                 845             

Tyr Ala Leu Asp Met Ser Asp Thr Ile Gly Glu Gly Gln Lys Asp Ala 
    850                 855                 860                 

Tyr Gly Asn Pro Ile Leu Asn Val Asp Glu Asp Asn Glu Gly Tyr His 
865                 870                 875                 880 

Ala Leu Ala Val Ala Thr Leu Ala Asp Tyr Glu Gly Leu Asp Ile Lys 
                885                 890                 895     

Thr Ile Leu Asn Ser Lys Leu Ser Gln Leu Thr Ser Ile Arg Gln Val 
            900                 905                 910         

Pro Thr Ala Ala Tyr His Arg Ala Gly Ile Phe Gln Ala Ile Gln Asn 
        915                 920                 925             

Ala Ala Ala Glu Ala Glu Gln Leu Leu Pro Lys Pro Gly Thr His Ser 
    930                 935                 940                 

Glu Lys Ser Ser Ser Ser Glu Ser Ala Asn Ser Lys Asp Arg Gly Leu 
945                 950                 955                 960 

Gln Ser Asn Pro Lys Thr Asn Arg Gly Arg His Ser Ala Ile Leu Pro 
                965                 970                 975     

Arg Thr Gly Ser Lys Gly Ser Phe Val Tyr Gly Ile Leu Gly Tyr Thr 
            980                 985                 990         

Ser Val Ala Leu Leu Ser Leu Ile Thr Ala Ile Lys Lys Lys Lys Tyr 
        995                 1000                1005            


<210>   33
<211>   364
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   33
Met Val Asp Leu Gly Phe Ser Leu Tyr Pro Glu Arg Tyr Asp Val Thr 
1               5                   10                  15      

Lys Ser Lys Ala Tyr Ile Asp Leu Cys His Ser Tyr Gly Ala Lys Arg 
            20                  25                  30          

Leu Phe Met Ser Leu Leu Gln Leu Ala Pro Ala Asp His Gln Met Phe 
        35                  40                  45              

His Cys Tyr Ala Glu Leu Ile Ala Tyr Ala Asn Gln Leu Gly Ile Arg 
    50                  55                  60                  

Val Ile Ala Asp Val Ser Pro Ser Phe Ile Ser Gln Ala Gly Trp Ser 
65                  70                  75                  80  

Asp Gln Leu Ile Glu Arg Ala His Ala Phe Gly Leu Ala Gly Leu Arg 
                85                  90                  95      

Leu Asp Glu Ala Leu Pro Leu Ala Glu Ile Val Thr Leu Thr Arg Asn 
            100                 105                 110         

Pro Phe Gly Leu Lys Ile Glu Leu Asn Met Ser Thr Asp Lys Gln Leu 
        115                 120                 125             

Leu Met Ser Leu Leu Ala Thr Asp Ala Glu Arg Ser Asn Ile Ile Gly 
    130                 135                 140                 

Cys His Asn Phe Tyr Pro His Glu Phe Thr Gly Leu Ser Trp Gln His 
145                 150                 155                 160 

Phe Lys Asp Met Ser Arg Phe Tyr His Glu His Asp Ile Glu Thr Ala 
                165                 170                 175     

Ala Phe Ile Thr Ala Gln Ser Ala Ser Glu Gly Pro Trp Leu Leu Ala 
            180                 185                 190         

Glu Gly Leu Pro Thr Val Glu Asp His Arg His Leu Pro Ile Gly Leu 
        195                 200                 205             

Gln Val Glu Leu Met Lys Ala Ile Gly Thr Ile Asp Asn Ile Leu Ile 
    210                 215                 220                 

Ser Asn Gln Phe Ile Ser Glu Glu Glu Leu Ala Ala Cys Thr Gln Ala 
225                 230                 235                 240 

Leu Ala Arg Pro Val Thr Thr Ile Lys Val Arg Pro Ile Ile Asp Leu 
                245                 250                 255     

Thr Glu Val Glu Glu Gln Ile Ile Gly Tyr Pro His Cys Tyr Arg Gly 
            260                 265                 270         

Asp Val Ser Asp Tyr Val Ile Arg Ser Thr Met Pro Arg Leu Val Tyr 
        275                 280                 285             

Ala Gln Glu Ser Ile Ala Pro Arg Asp Gln Ser Lys Glu Val Lys Arg 
    290                 295                 300                 

Gly Ser Ile Ile Ile Asp Asn Asp Arg Tyr His Arg Tyr Lys Gly Glu 
305                 310                 315                 320 

Leu Gln Ile Ala Leu Lys Asn Phe Thr Val Ser Ser Lys Ala Asn Val 
                325                 330                 335     

Val Ala Glu Val Arg Glu Asp Tyr Leu Ser Leu Leu Asp Asp Leu Arg 
            340                 345                 350         

Pro Trp Gln Glu Phe Cys Leu Glu Ile Ala Pro Ser 
        355                 360                 

<210>   34
<211>   1165
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (1133) ... (1165)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   34
Met Lys Lys Lys Val Asn Gln Gly Ser Lys Arg Tyr Gln Tyr Leu Leu 
1               5                   10                  15      

Lys Lys Trp Gly Ile Gly Phe Val Ile Ala Ala Thr Gly Thr Val Val 
            20                  25                  30          

Leu Gly Cys Thr Pro Ser Ile Leu Thr His Gln Val Ala Ala Lys Thr 
        35                  40                  45              

Ile Val Gly Leu Ala Arg Asp Glu Ala Gln Gln Gly Asp Gly Asn Ala 
    50                  55                  60                  

Lys Ser Gly Asp Gly Leu Gln Ser Ser Ser Lys Glu Ala Lys Pro Val 
65                  70                  75                  80  

Leu Asp Ser Ser Ser Ala Asn Pro Ala Ser Ile Ala Glu His His Leu 
                85                  90                  95      

Arg Met His Phe Lys Thr Leu Pro Ala Gly Glu Ser Leu Gly Ser Leu 
            100                 105                 110         

Gly Leu Trp Val Trp Gly Asp Val Asp Gln Pro Ser Lys Asp Trp Pro 
        115                 120                 125             

Asn Gly Ala Ile Thr Met Thr Lys Ala Lys Lys Asp Asp Tyr Gly Tyr 
    130                 135                 140                 

Tyr Leu Asp Val Pro Leu Ala Ala Lys His Arg Gln Gln Val Ser Tyr 
145                 150                 155                 160 

Leu Ile Asn Asn Lys Ala Gly Glu Asn Leu Ser Lys Asp Gln His Ile 
                165                 170                 175     

Ser Leu Leu Thr Pro Lys Met Asn Glu Val Trp Ile Asp Glu Asn Tyr 
            180                 185                 190         

His Ala His Ala Tyr Arg Pro Leu Lys Lys Gly Tyr Leu Arg Ile Asn 
        195                 200                 205             

Tyr His Asn Gln Ser Gly His Tyr Asp Asn Leu Ala Val Trp Thr Phe 
    210                 215                 220                 

Lys Asp Val Lys Thr Pro Thr Thr Asp Trp Pro Asn Gly Leu Asp Leu 
225                 230                 235                 240 

Ser His Lys Gly His Tyr Gly Ala Tyr Val Asp Val Pro Leu Lys Glu 
                245                 250                 255     

Gly Ala Asn Glu Ile Gly Phe Leu Ile Leu Asp Lys Ser Lys Thr Gly 
            260                 265                 270         

Asp Ala Ile Lys Val Gln Pro Lys Asp Tyr Leu Phe Lys Glu Leu Asp 
        275                 280                 285             

Asn His Thr Gln Val Phe Val Lys Asp Thr Asp Pro Lys Val Tyr Asn 
    290                 295                 300                 

Asn Pro Tyr Tyr Ile Asp Gln Val Ser Leu Lys Gly Ala Glu Gln Thr 
305                 310                 315                 320 

Thr Pro Asn Glu Ile Lys Ala Ile Phe Thr Thr Leu Asp Gly Leu Asp 
                325                 330                 335     

Glu Asp Ala Val Lys Gln Asn Ile Lys Ile Thr Asp Lys Ala Gly Lys 
            340                 345                 350         

Thr Val Ala Ile Asp Glu Leu Thr Leu Asp Arg Asp Lys Ser Val Met 
        355                 360                 365             

Thr Leu Lys Gly Asp Phe Lys Ala Gln Gly Ala Val Tyr Thr Val Thr 
    370                 375                 380                 

Phe Gly Glu Val Ser Gln Val Ala Arg Gln Ser Trp Gln Leu Lys Asp 
385                 390                 395                 400 

Lys Leu Tyr Ala Tyr Asp Gly Glu Leu Gly Ala Thr Leu Ala Lys Asp 
                405                 410                 415     

Gly Ser Val Asp Leu Ala Leu Trp Ser Pro Ser Ala Asp Thr Val Lys 
            420                 425                 430         

Val Val Val Tyr Asp Lys Gln Asp Gln Thr Arg Val Val Gly Gln Ala 
        435                 440                 445             

Asp Leu Thr Lys Ser Asp Lys Gly Val Trp Arg Ala His Leu Thr Ser 
    450                 455                 460                 

Asp Ser Val Lys Gly Ile Ser Asp Tyr Thr Gly Tyr Tyr Tyr Leu Tyr 
465                 470                 475                 480 

Glu Ile Thr Arg Gly Gln Glu Lys Val Met Val Leu Asp Pro Tyr Ala 
                485                 490                 495     

Lys Ser Leu Ala Ala Trp Asn Asp Ala Thr Ala Thr Asp Asp Ile Lys 
            500                 505                 510         

Thr Ala Lys Ala Ala Phe Ile Asp Pro Ser Lys Leu Gly Pro Thr Gly 
        515                 520                 525             

Leu Asp Phe Ala Lys Ile Asn Asn Phe Lys Lys Arg Glu Asp Ala Ile 
    530                 535                 540                 

Ile Tyr Glu Ala His Val Arg Asp Phe Thr Ser Asp Lys Ala Leu Glu 
545                 550                 555                 560 

Gly Lys Leu Thr His Pro Phe Gly Thr Phe Ser Ala Phe Val Glu Gln 
                565                 570                 575     

Leu Asp Tyr Leu Lys Asp Leu Gly Val Thr His Val Gln Leu Leu Pro 
            580                 585                 590         

Val Leu Ser Tyr Phe Tyr Ala Asn Glu Leu Asp Lys Ser Arg Ser Thr 
        595                 600                 605             

Ala Tyr Thr Ser Ser Asp Asn Asn Tyr Asn Trp Gly Tyr Asp Pro Gln 
    610                 615                 620                 

His Tyr Phe Ala Leu Ser Gly Met Tyr Ser Ala Asn Pro Asn Asp Pro 
625                 630                 635                 640 

Ala Leu Arg Ile Ala Glu Leu Lys Asn Leu Val Asn Glu Ile His Lys 
                645                 650                 655     

Arg Gly Met Gly Val Ile Phe Asp Val Val Tyr Asn His Thr Ala Arg 
            660                 665                 670         

Thr Tyr Leu Phe Glu Asp Leu Glu Pro Asn Tyr Tyr His Phe Met Asn 
        675                 680                 685             

Ala Asp Gly Thr Ala Arg Glu Ser Phe Gly Gly Gly Arg Leu Gly Thr 
    690                 695                 700                 

Thr His Ala Met Ser Arg Arg Ile Leu Val Asp Ser Ile Thr Tyr Leu 
705                 710                 715                 720 

Thr Arg Glu Phe Lys Val Asp Gly Phe Arg Phe Asp Met Met Gly Asp 
                725                 730                 735     

His Asp Ala Ala Ala Ile Glu Gln Ala Phe Lys Ala Ala Lys Ala Ile 
            740                 745                 750         

Asn Pro Asn Thr Ile Met Ile Gly Glu Gly Trp Arg Thr Tyr Gln Gly 
        755                 760                 765             

Asp Glu Gly Lys Lys Glu Ile Ala Ala Asp Gln Asp Trp Met Lys Ala 
    770                 775                 780                 

Thr Asn Thr Val Gly Val Phe Ser Asp Asp Ile Arg Asn Thr Leu Lys 
785                 790                 795                 800 

Ser Gly Phe Pro Asn Glu Gly Thr Ala Ala Phe Ile Thr Gly Gly Ala 
                805                 810                 815     

Lys Asn Leu Glu Gly Leu Phe Lys Thr Ile Lys Ala Gln Pro Gly Asn 
            820                 825                 830         

Phe Glu Ala Asp Ala Pro Gly Asp Val Val Gln Tyr Ile Ala Ala His 
        835                 840                 845             

Asp Asn Leu Thr Leu His Asp Val Ile Ala Lys Ser Ile Asn Lys Asp 
    850                 855                 860                 

Pro Lys Val Ala Glu Glu Glu Ile His Lys Arg Ile Arg Leu Gly Asn 
865                 870                 875                 880 

Thr Met Ile Leu Thr Ala Gln Gly Thr Ala Phe Ile His Ser Gly Gln 
                885                 890                 895     

Glu Tyr Gly Arg Thr Lys Gln Leu Leu Asn Pro Asp Tyr Lys Thr Lys 
            900                 905                 910         

Ala Ser Asp Asp Lys Val Pro Asn Lys Ala Thr Leu Ile Asp Ala Val 
        915                 920                 925             

Ala Gln Tyr Pro Tyr Phe Ile His Asp Ser Tyr Asp Ser Ser Asp Ala 
    930                 935                 940                 

Val Asn His Phe Asp Trp Ala Lys Ala Thr Asp Ser Ile Ala His Pro 
945                 950                 955                 960 

Ile Ser Asn Gln Thr Lys Ala Tyr Thr Gln Gly Leu Ile Ala Leu Arg 
                965                 970                 975     

Arg Ser Thr Asp Ala Phe Thr Lys Ala Thr Lys Ala Glu Val Asp Arg 
            980                 985                 990         

Asp Val Thr Leu Ile Thr Gln Ala Gly Gln Asp Gly Ile Gln Gln Glu 
        995                 1000                1005            

Asp Leu Ile Met Gly Tyr Gln Thr Val Ala Ser Asn Gly Asp Arg Tyr 
    1010                1015                1020                

Ala Val Phe Val Asn Ala Asp Asn Lys Thr Arg Lys Val Val Leu Pro 
1025                1030                1035                1040

Gln Ala Tyr Arg Tyr Leu Leu Gly Ala Gln Val Leu Val Asp Ala Glu 
                1045                1050                1055    

Gln Ala Gly Val Thr Ala Ile Ala Lys Pro Lys Gly Val Gln Phe Thr 
            1060                1065                1070        

Lys Glu Gly Leu Thr Ile Glu Gly Leu Thr Ala Leu Val Leu Lys Val 
        1075                1080                1085            

Ser Ser Lys Thr Ala Asn Pro Ser Gln Gln Lys Ser Gln Thr Asp Asn 
    1090                1095                1100                

His Gln Thr Lys Thr Pro Asp Gly Ser Lys Asp Leu Asp Lys Ser Leu 
1105                1110                1115                1120

Met Thr Arg Pro Lys Arg Ala Lys Thr Asn Gln Lys Leu Pro Lys Thr 
                1125                1130                1135    

Gly Glu Ala Ser Ser Lys Gly Leu Leu Ala Ala Gly Ile Ala Leu Leu 
            1140                1145                1150        

Leu Leu Ala Ile Ser Leu Leu Met Lys Arg Gln Lys Asp 
        1155                1160                1165

<210>   35
<211>   348
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (37)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (314) ... (348)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   35
Met Leu Thr Ser Lys His His Asn Leu Asn Lys Leu Val Trp Arg Tyr 
1               5                   10                  15      

Gly Leu Thr Ser Ala Ala Ala Val Leu Leu Ala Phe Gly Gly Gly Ala 
            20                  25                  30          

Ser Ser Val Lys Ala Glu Val Ser Ser Thr Thr Met Thr Ser Ser Gln 
        35                  40                  45              

Arg Glu Ser Lys Ile Lys Glu Ile Glu Glu Ser Leu Lys Lys Tyr Pro 
    50                  55                  60                  

Glu Val Ser Asn Glu Lys Phe Trp Glu Arg Lys Trp Tyr Gly Thr Tyr 
65                  70                  75                  80  

Phe Lys Glu Glu Asp Phe Gln Lys Glu Leu Lys Asp Phe Thr Glu Lys 
                85                  90                  95      

Arg Leu Lys Glu Ile Leu Asp Leu Ile Gly Lys Ser Gly Ile Lys Gly 
            100                 105                 110         

Asp Arg Gly Glu Thr Gly Pro Ala Gly Pro Ala Gly Pro Gln Gly Lys 
        115                 120                 125             

Thr Gly Glu Arg Gly Ala Gln Gly Pro Lys Gly Asp Arg Gly Glu Gln 
    130                 135                 140                 

Gly Ile Gln Gly Lys Ala Gly Glu Lys Gly Glu Arg Gly Glu Lys Gly 
145                 150                 155                 160 

Asp Lys Gly Glu Thr Gly Glu Arg Gly Glu Lys Gly Glu Ala Gly Ile 
                165                 170                 175     

Gln Gly Pro Gln Gly Glu Ala Gly Lys Asp Gly Ala Pro Gly Lys Asp 
            180                 185                 190         

Gly Ala Pro Gly Glu Lys Gly Glu Lys Gly Asp Arg Gly Glu Thr Gly 
        195                 200                 205             

Ala Gln Gly Pro Val Gly Pro Gln Gly Glu Lys Gly Glu Thr Gly Ala 
    210                 215                 220                 

Gln Gly Pro Ala Gly Pro Gln Gly Glu Ala Gly Lys Pro Gly Glu Gln 
225                 230                 235                 240 

Gly Pro Ala Gly Pro Gln Gly Glu Ala Gly Gln Pro Gly Glu Lys Ala 
                245                 250                 255     

Pro Glu Lys Ser Pro Glu Gly Glu Ala Gly Gln Pro Gly Glu Lys Ala 
            260                 265                 270         

Pro Glu Lys Ser Lys Glu Val Thr Pro Ala Ala Glu Lys Pro Ala Asp 
        275                 280                 285             

Lys Glu Ala Asn Gln Thr Pro Glu Arg Arg Asn Gly Asn Met Ala Lys 
    290                 295                 300                 

Thr Pro Val Ala Asn Asn His Arg Arg Leu Pro Ala Thr Gly Glu Gln 
305                 310                 315                 320 

Ala Asn Pro Phe Phe Thr Ala Ala Ala Val Ala Val Met Thr Thr Ala 
                325                 330                 335     

Gly Val Leu Ala Val Thr Lys Arg Lys Glu Asn Asn 
            340                 345             

<210>   36
<211>   379
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (37)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (344) ... (379)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   36
Met Arg Arg Ala Glu Asn Asn Lys His Ser Arg Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Leu Ser Val Gly Val Thr Ser Ile Ala Ile Ala Ser Leu Phe Leu Gly 
            20                  25                  30          

Lys Val Ala Tyr Ala Val Asp Gly Ile Pro Pro Ile Ser Leu Thr Gln 
        35                  40                  45              

Lys Thr Thr Ala Thr Thr Ser Glu Asn Trp His His Ile Asp Lys Asp 
    50                  55                  60                  

Gly Leu Ile Pro Leu Gly Ile Ser Leu Glu Ala Ala Lys Glu Glu Phe 
65                  70                  75                  80  

Lys Lys Glu Val Glu Glu Ser Arg Leu Ser Glu Ala Gln Lys Glu Thr 
                85                  90                  95      

Tyr Lys Gln Lys Ile Lys Thr Ala Pro Asp Lys Asp Lys Leu Leu Phe 
            100                 105                 110         

Thr Tyr His Ser Glu Tyr Met Thr Ala Val Lys Asp Leu Pro Ala Ser 
        115                 120                 125             

Thr Glu Ser Thr Thr Gln Pro Val Glu Ala Pro Val Gln Glu Thr Gln 
    130                 135                 140                 

Ala Ser Ala Ser Asp Ser Met Val Thr Gly Asp Ser Thr Ser Val Thr 
145                 150                 155                 160 

Thr Asp Ser Pro Glu Glu Thr Pro Ser Ser Glu Ser Pro Val Ala Pro 
                165                 170                 175     

Ala Leu Ser Glu Ala Pro Ala Gln Pro Ala Glu Ser Glu Glu Pro Ser 
            180                 185                 190         

Val Ala Ala Ser Ser Glu Glu Thr Pro Ser Pro Ser Thr Pro Ala Ala 
        195                 200                 205             

Pro Glu Thr Pro Glu Glu Pro Ala Ala Pro Ser Pro Ser Pro Glu Ser 
    210                 215                 220                 

Glu Glu Pro Ser Val Ala Ala Pro Ser Glu Glu Thr Pro Ser Pro Glu 
225                 230                 235                 240 

Thr Pro Glu Glu Pro Ala Ala Pro Ser Gln Pro Ala Glu Ser Glu Glu 
                245                 250                 255     

Ser Ser Val Ala Ala Thr Thr Ser Pro Ser Pro Ser Thr Pro Ala Glu 
            260                 265                 270         

Ser Glu Thr Gln Thr Pro Pro Ala Val Thr Lys Asp Ser Asp Lys Pro 
        275                 280                 285             

Ser Ser Ala Ala Glu Lys Pro Ala Ala Ser Ser Leu Val Ser Glu Gln 
    290                 295                 300                 

Thr Val Gln Gln Pro Thr Ser Lys Arg Ser Ser Asp Lys Lys Glu Glu 
305                 310                 315                 320 

Gln Glu Gln Ser Tyr Ser Pro Asn Arg Ser Leu Ser Arg Gln Val Arg 
                325                 330                 335     

Ala His Glu Ser Gly Lys Tyr Leu Pro Ser Thr Gly Glu Lys Ala Gln 
            340                 345                 350         

Pro Leu Phe Ile Ala Thr Met Thr Leu Met Ser Leu Phe Gly Ser Leu 
        355                 360                 365             

Leu Val Thr Lys Arg Gln Lys Glu Thr Lys Lys 
    370                 375                 

<210>   37
<211>   1181
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (25)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (1144) ... (1181)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   37
Met Arg Lys Lys Gln Lys Leu Pro Phe Asp Lys Leu Ala Ile Ala Leu 
1               5                   10                  15      

Met Ser Thr Ser Ile Leu Leu Asn Ala Gln Ser Asp Ile Lys Ala Asn 
            20                  25                  30          

Thr Val Thr Glu Asp Thr Pro Ala Thr Glu Gln Ala Val Glu Thr Pro 
        35                  40                  45              

Gln Pro Thr Ala Val Ser Glu Glu Ala Pro Ser Ser Lys Glu Thr Lys 
    50                  55                  60                  

Thr Pro Gln Thr Pro Asp Asp Ala Glu Glu Thr Ile Ala Asp Asp Ala 
65                  70                  75                  80  

Asn Asp Leu Ala Pro Gln Ala Pro Ala Lys Thr Ala Asp Thr Pro Ala 
                85                  90                  95      

Thr Ser Lys Ala Thr Ile Arg Asp Leu Asn Asp Pro Ser Gln Val Lys 
            100                 105                 110         

Thr Leu Gln Glu Lys Ala Gly Lys Gly Ala Gly Thr Val Val Ala Val 
        115                 120                 125             

Ile Asp Ala Gly Phe Asp Lys Asn His Glu Ala Trp Arg Leu Thr Asp 
    130                 135                 140                 

Lys Thr Lys Ala Arg Tyr Gln Ser Lys Glu Asp Leu Glu Lys Ala Lys 
145                 150                 155                 160 

Lys Glu His Gly Ile Thr Tyr Gly Glu Trp Val Asn Asp Lys Val Ala 
                165                 170                 175     

Tyr Tyr His Asp Tyr Ser Lys Asp Gly Lys Thr Ala Val Asp Gln Glu 
            180                 185                 190         

His Gly Thr His Val Ser Gly Ile Leu Ser Gly Asn Ala Pro Ser Glu 
        195                 200                 205             

Thr Lys Glu Pro Tyr Arg Leu Glu Gly Ala Met Pro Glu Ala Gln Leu 
    210                 215                 220                 

Leu Leu Met Arg Val Glu Ile Val Asn Gly Leu Ala Asp Tyr Ala Arg 
225                 230                 235                 240 

Asn Tyr Ala Gln Ala Ile Ile Asp Ala Val Asn Leu Gly Ala Lys Val 
                245                 250                 255     

Ile Asn Met Ser Phe Gly Asn Ala Ala Leu Ala Tyr Ala Asn Leu Pro 
            260                 265                 270         

Asp Glu Thr Lys Lys Ala Phe Asp Tyr Ala Lys Ser Lys Gly Val Ser 
        275                 280                 285             

Ile Val Thr Ser Ala Gly Asn Asp Ser Ser Phe Gly Gly Lys Thr Arg 
    290                 295                 300                 

Leu Pro Leu Ala Asp His Pro Asp Tyr Gly Val Val Gly Thr Pro Ala 
305                 310                 315                 320 

Ala Ala Asp Ser Thr Leu Thr Val Ala Ser Tyr Ser Pro Asp Lys Gln 
                325                 330                 335     

Leu Thr Glu Thr Ala Thr Val Lys Thr Ala Asp Gln Gln Asp Lys Glu 
            340                 345                 350         

Met Pro Val Leu Ser Thr Asn Arg Phe Glu Pro Asn Lys Ala Tyr Asp 
        355                 360                 365             

Tyr Ala Tyr Ala Asn Arg Gly Met Lys Glu Asp Asp Phe Lys Asp Val 
    370                 375                 380                 

Lys Gly Lys Ile Ala Leu Ile Glu Arg Gly Asp Ile Asp Phe Lys Asp 
385                 390                 395                 400 

Lys Ile Ala Asn Ala Lys Lys Ala Gly Ala Val Gly Val Leu Ile Tyr 
                405                 410                 415     

Asp Asn Gln Asp Lys Gly Phe Pro Ile Glu Leu Pro Asn Val Asp Gln 
            420                 425                 430         

Met Pro Ala Ala Phe Ile Ser Arg Lys Asp Gly Leu Leu Leu Lys Glu 
        435                 440                 445             

Asn Pro Gln Lys Thr Ile Thr Phe Asn Ala Thr Pro Lys Val Leu Pro 
    450                 455                 460                 

Thr Ala Ser Gly Thr Lys Leu Ser Arg Phe Ser Ser Trp Gly Leu Thr 
465                 470                 475                 480 

Ala Asp Gly Asn Ile Lys Pro Asp Ile Ala Ala Pro Gly Gln Asp Ile 
                485                 490                 495     

Leu Ser Ser Val Ala Asn Asn Lys Tyr Ala Lys Leu Ser Gly Thr Ser 
            500                 505                 510         

Met Ser Ala Pro Leu Val Ala Gly Ile Met Gly Leu Leu Gln Lys Gln 
        515                 520                 525             

Tyr Glu Thr Gln Tyr Pro Asp Met Thr Pro Ser Glu Arg Leu Asp Leu 
    530                 535                 540                 

Ala Lys Lys Val Leu Met Ser Ser Ala Thr Ala Leu Tyr Asp Glu Asp 
545                 550                 555                 560 

Glu Lys Ala Tyr Phe Ser Pro Arg Gln Gln Gly Ala Gly Ala Val Asp 
                565                 570                 575     

Ala Lys Lys Ala Ser Ala Ala Thr Met Tyr Val Thr Asp Lys Asp Asn 
            580                 585                 590         

Thr Ser Ser Lys Val His Leu Asn Asn Val Ser Asp Lys Phe Glu Val 
        595                 600                 605             

Thr Val Thr Val His Asn Lys Ser Asp Lys Pro Gln Glu Leu Tyr Tyr 
    610                 615                 620                 

Gln Ala Thr Val Gln Thr Asp Lys Val Asp Gly Lys Leu Phe Ala Leu 
625                 630                 635                 640 

Ala Pro Lys Ala Leu Tyr Glu Thr Ser Trp Gln Lys Ile Thr Ile Pro 
                645                 650                 655     

Ala Asn Ser Ser Lys Gln Val Thr Ile Pro Ile Asp Val Ser Gln Phe 
            660                 665                 670         

Ser Lys Asp Leu Leu Ala Pro Met Lys Asn Gly Tyr Phe Leu Glu Gly 
        675                 680                 685             

Phe Val Arg Phe Lys Gln Asp Pro Thr Lys Glu Glu Leu Met Ser Ile 
    690                 695                 700                 

Pro Tyr Ile Gly Phe Arg Gly Asp Phe Gly Asn Leu Ser Ala Leu Glu 
705                 710                 715                 720 

Lys Pro Ile Tyr Asp Ser Lys Asp Gly Ser Ser Tyr Tyr His Glu Ala 
                725                 730                 735     

Asn Ser Asp Ala Lys Asp Gln Leu Asp Gly Asp Gly Leu Gln Phe Tyr 
            740                 745                 750         

Ala Leu Lys Asn Asn Phe Thr Ala Leu Thr Thr Glu Ser Asn Pro Trp 
        755                 760                 765             

Thr Ile Ile Lys Ala Val Lys Glu Gly Val Glu Asn Ile Glu Asp Ile 
    770                 775                 780                 

Glu Ser Ser Glu Ile Thr Glu Thr Ile Phe Ala Gly Thr Phe Ala Lys 
785                 790                 795                 800 

Gln Asp Asp Asp Ser His Tyr Tyr Ile His Arg His Ala Asn Gly Lys 
                805                 810                 815     

Pro Tyr Ala Ala Ile Ser Pro Asn Gly Asp Gly Asn Arg Asp Tyr Val 
            820                 825                 830         

Gln Phe Gln Gly Thr Phe Leu Arg Asn Ala Lys Asn Leu Val Ala Glu 
        835                 840                 845             

Val Leu Asp Lys Glu Gly Asn Val Val Trp Thr Ser Glu Val Thr Glu 
    850                 855                 860                 

Gln Val Val Lys Asn Tyr Asn Asn Asp Leu Ala Ser Thr Leu Gly Ser 
865                 870                 875                 880 

Thr Arg Phe Glu Lys Thr Arg Trp Asp Gly Lys Asp Lys Asp Gly Lys 
                885                 890                 895     

Val Val Ala Asn Gly Thr Tyr Thr Tyr Arg Val Arg Tyr Thr Pro Ile 
            900                 905                 910         

Ser Ser Gly Ala Lys Glu Gln His Thr Asp Phe Asp Val Ile Val Asp 
        915                 920                 925             

Asn Thr Thr Pro Glu Val Ala Thr Ser Ala Thr Phe Ser Thr Glu Asp 
    930                 935                 940                 

Arg Arg Leu Thr Leu Ala Ser Lys Pro Lys Thr Ser Gln Pro Val Tyr 
945                 950                 955                 960 

Arg Glu Arg Ile Ala Tyr Thr Tyr Met Asp Glu Asp Leu Pro Thr Thr 
                965                 970                 975     

Glu Tyr Ile Ser Pro Asn Glu Asp Gly Thr Phe Thr Leu Pro Glu Glu 
            980                 985                 990         

Ala Glu Thr Met Glu Gly Ala Thr Val Pro Leu Lys Met Ser Asp Phe 
        995                 1000                1005            

Thr Tyr Val Val Glu Asp Met Ala Gly Asn Ile Thr Tyr Thr Pro Val 
    1010                1015                1020                

Thr Lys Leu Leu Glu Gly His Ser Asn Lys Pro Glu Gln Asp Gly Ser 
1025                1030                1035                1040

Asp Gln Ala Pro Asp Lys Lys Pro Glu Thr Lys Pro Glu Gln Asp Gly 
                1045                1050                1055    

Ser Gly Gln Ala Pro Asp Lys Lys Pro Glu Thr Lys Pro Glu Gln Asp 
            1060                1065                1070        

Gly Ser Gly Gln Thr Pro Asp Lys Lys Pro Glu Thr Lys Pro Glu Gln 
        1075                1080                1085            

Asp Gly Ser Gly Gln Thr Pro Asp Lys Lys Pro Glu Thr Lys Pro Glu 
    1090                1095                1100                

Lys Asp Ser Ser Gly Gln Thr Pro Gly Lys Thr Pro Gln Lys Gly Gln 
1105                1110                1115                1120

Pro Ser Arg Thr Leu Glu Lys Arg Ser Ser Lys Arg Ala Leu Ala Thr 
                1125                1130                1135    

Lys Ala Ser Thr Lys Asp Gln Leu Pro Thr Thr Asn Asp Lys Asp Thr 
            1140                1145                1150        

Asn Arg Leu His Leu Leu Lys Leu Val Met Thr Thr Phe Phe Leu Gly 
        1155                1160                1165            

Leu Val Ala His Ile Phe Lys Thr Lys Arg Thr Glu Asp 
    1170                1175                1180    

<210>   38
<211>   484
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (450)  (484)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   38
Met Ala Lys Asn Asn Thr Asn Arg His Tyr Ser Leu Arg Lys Leu Lys 
1               5                   10                  15      

Thr Gly Thr Ala Ser Val Ala Val Ala Leu Thr Val Leu Gly Ala Gly 
            20                  25                  30          

Phe Ala Asn Gln Thr Glu Val Lys Ala Asn Gly Asp Gly Asn Pro Arg 
        35                  40                  45              

Glu Val Ile Glu Asp Leu Ala Ala Asn Asn Pro Ala Ile Gln Asn Ile 
    50                  55                  60                  

Arg Leu Arg Tyr Glu Asn Lys Asp Leu Lys Ala Arg Leu Glu Asn Ala 
65                  70                  75                  80  

Met Glu Val Ala Gly Arg Asp Phe Lys Arg Ala Glu Glu Leu Glu Lys 
                85                  90                  95      

Ala Lys Gln Ala Leu Glu Asp Gln Arg Lys Asp Leu Glu Thr Lys Leu 
            100                 105                 110         

Lys Glu Leu Gln Gln Asp Tyr Asp Leu Ala Lys Glu Ser Thr Ser Trp 
        115                 120                 125             

Asp Arg Gln Arg Leu Glu Lys Glu Leu Glu Glu Lys Lys Glu Ala Leu 
    130                 135                 140                 

Glu Leu Ala Ile Asp Gln Ala Ser Arg Asp Tyr His Arg Ala Thr Ala 
145                 150                 155                 160 

Leu Glu Lys Glu Leu Glu Glu Lys Lys Lys Ala Leu Glu Leu Ala Ile 
                165                 170                 175     

Asp Gln Ala Ser Gln Asp Tyr Asn Arg Ala Asn Val Leu Glu Lys Glu 
            180                 185                 190         

Leu Glu Thr Ile Thr Arg Glu Gln Glu Ile Asn Arg Asn Leu Leu Gly 
        195                 200                 205             

Asn Ala Lys Leu Glu Leu Asp Gln Leu Ser Ser Glu Lys Glu Gln Leu 
    210                 215                 220                 

Thr Ile Glu Lys Ala Lys Leu Glu Glu Glu Lys Gln Ile Ser Asp Ala 
225                 230                 235                 240 

Ser Arg Gln Ser Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys 
                245                 250                 255     

Lys Gln Val Glu Lys Asp Leu Ala Asn Leu Thr Ala Glu Leu Asp Lys 
            260                 265                 270         

Val Lys Glu Asp Lys Gln Ile Ser Asp Ala Ser Arg Gln Gly Leu Arg 
        275                 280                 285             

Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Asp 
    290                 295                 300                 

Leu Ala Asn Leu Thr Ala Glu Leu Asp Lys Val Lys Glu Glu Lys Gln 
305                 310                 315                 320 

Ile Ser Asp Ala Ser Arg Gln Gly Leu Arg Arg Asp Leu Asp Ala Ser 
                325                 330                 335     

Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu Glu Glu Ala Asn Ser 
            340                 345                 350         

Lys Leu Ala Ala Leu Glu Lys Leu Asn Lys Glu Leu Glu Glu Ser Lys 
        355                 360                 365             

Lys Leu Thr Glu Lys Glu Lys Ala Glu Leu Gln Ala Lys Leu Glu Ala 
    370                 375                 380                 

Glu Ala Lys Ala Leu Lys Glu Gln Leu Ala Lys Gln Ala Glu Glu Leu 
385                 390                 395                 400 

Ala Lys Leu Arg Ala Gly Lys Ala Ser Asp Ser Gln Thr Pro Asp Thr 
                405                 410                 415     

Lys Pro Gly Asn Lys Ala Val Pro Gly Lys Gly Gln Ala Pro Gln Ala 
            420                 425                 430         

Gly Thr Lys Pro Asn Gln Asn Lys Ala Pro Met Lys Glu Thr Lys Arg 
        435                 440                 445             

Gln Leu Pro Ser Thr Gly Glu Thr Ala Asn Pro Phe Phe Thr Ala Ala 
    450                 455                 460                 

Ala Leu Thr Val Met Ala Thr Ala Gly Val Ala Ala Val Val Lys Arg 
465                 470                 475                 480 

Lys Glu Glu Asn 
                

<210>   39
<211>   541
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   39
Met Lys Lys Arg Lys Leu Leu Ala Val Thr Leu Leu Ser Thr Ile Leu 
1               5                   10                  15      

Leu Asn Ser Ala Val Pro Leu Val Val Ala Asp Thr Ser Leu Arg Asn 
            20                  25                  30          

Ser Thr Ser Ser Thr Asp Gln Pro Thr Thr Ala Asp Thr Asp Thr Asp 
        35                  40                  45              

Asp Glu Ser Glu Thr Pro Lys Lys Asp Lys Lys Ser Lys Glu Thr Ala 
    50                  55                  60                  

Ser Gln His Asp Thr Gln Lys Asp His Lys Pro Ser His Thr His Pro 
65                  70                  75                  80  

Thr Pro Pro Ser Asn Asp Thr Lys Gln Thr Asp Gln Ala Ser Ser Glu 
                85                  90                  95      

Ala Thr Asp Lys Pro Asn Lys Asp Lys Asn Asp Thr Lys Gln Pro Asp 
            100                 105                 110         

Ser Ser Asp Gln Ser Thr Pro Ser Pro Lys Asp Gln Ser Ser Gln Lys 
        115                 120                 125             

Glu Ser Gln Asn Lys Asp Gly Arg Pro Thr Pro Ser Pro Asp Gln Gln 
    130                 135                 140                 

Lys Asp Gln Thr Pro Asp Lys Thr Pro Glu Lys Ser Ala Asp Lys Thr 
145                 150                 155                 160 

Pro Glu Lys Gly Pro Glu Lys Ala Thr Asp Lys Thr Pro Glu Pro Asn 
                165                 170                 175     

Arg Asp Ala Pro Lys Pro Ile Gln Pro Pro Leu Ala Ala Ala Pro Val 
            180                 185                 190         

Phe Ile Pro Trp Arg Glu Ser Asp Lys Asp Leu Ser Lys Leu Lys Pro 
        195                 200                 205             

Ser Ser Arg Ser Ser Ala Ala Tyr Val Arg His Trp Thr Gly Asp Ser 
    210                 215                 220                 

Ala Tyr Thr His Asn Leu Leu Ser Arg Arg Tyr Gly Ile Thr Ala Glu 
225                 230                 235                 240 

Gln Leu Asp Gly Phe Leu Asn Ser Leu Gly Ile His Tyr Asp Lys Glu 
                245                 250                 255     

Arg Leu Asn Gly Lys Arg Leu Leu Glu Trp Glu Lys Leu Thr Gly Leu 
            260                 265                 270         

Asp Val Arg Ala Ile Val Ala Ile Ala Met Ala Glu Ser Ser Leu Gly 
        275                 280                 285             

Thr Gln Gly Val Ala Lys Glu Lys Gly Ala Asn Met Phe Gly Tyr Gly 
    290                 295                 300                 

Ala Phe Asp Phe Asn Pro Asn Asn Ala Lys Lys Tyr Ser Asp Glu Val 
305                 310                 315                 320 

Ala Ile Arg His Met Val Glu Asp Thr Ile Ile Ala Asn Lys Asn Gln 
                325                 330                 335     

Thr Phe Glu Arg Gln Asp Leu Lys Ala Lys Lys Trp Ser Leu Gly Gln 
            340                 345                 350         

Leu Asp Thr Leu Ile Asp Gly Gly Val Tyr Phe Thr Asp Thr Ser Gly 
        355                 360                 365             

Ser Gly Gln Arg Arg Ala Asp Ile Met Thr Lys Leu Asp Gln Trp Ile 
    370                 375                 380                 

Asp Asp His Gly Ser Thr Pro Glu Ile Pro Glu His Leu Lys Ile Thr 
385                 390                 395                 400 

Ser Gly Thr Gln Phe Ser Glu Val Pro Val Gly Tyr Lys Arg Ser Gln 
                405                 410                 415     

Pro Gln Asn Val Leu Thr Tyr Lys Ser Glu Thr Tyr Ser Phe Gly Gln 
            420                 425                 430         

Cys Thr Trp Tyr Ala Tyr Asn Arg Val Lys Glu Leu Gly Tyr Gln Val 
        435                 440                 445             

Asp Arg Tyr Met Gly Asn Gly Gly Asp Trp Gln Arg Lys Pro Gly Phe 
    450                 455                 460                 

Val Thr Thr His Lys Pro Lys Val Gly Tyr Val Val Ser Phe Ala Pro 
465                 470                 475                 480 

Gly Gln Ala Gly Ala Asp Ala Thr Tyr Gly His Val Ala Val Val Glu 
                485                 490                 495     

Gln Ile Lys Glu Asp Gly Ser Ile Leu Ile Ser Glu Ser Asn Val Met 
            500                 505                 510         

Gly Leu Gly Thr Ile Ser Tyr Arg Thr Phe Thr Ala Glu Gln Ala Ser 
        515                 520                 525             

Leu Leu Thr Tyr Val Val Gly Asp Lys Leu Pro Arg Pro 
    530                 535                 540     

<210>   40
<211>   271
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   40
Met Asn Leu Leu Gly Ser Arg Arg Val Phe Ser Lys Lys Cys Arg Leu 
1               5                   10                  15      

Val Lys Phe Ser Met Val Ala Leu Val Ser Ala Thr Met Ala Val Thr 
            20                  25                  30          

Thr Val Thr Leu Glu Asn Thr Ala Leu Ala Arg Gln Thr Gln Val Ser 
        35                  40                  45              

Asn Asp Val Val Leu Asn Asp Gly Ala Ser Lys Tyr Leu Asn Glu Ala 
    50                  55                  60                  

Leu Ala Trp Thr Phe Asn Asp Ser Pro Asn Tyr Tyr Lys Thr Leu Gly 
65                  70                  75                  80  

Thr Ser Gln Ile Thr Pro Ala Leu Phe Pro Lys Ala Gly Asp Ile Leu 
                85                  90                  95      

Tyr Ser Lys Leu Asp Glu Leu Gly Arg Thr Arg Thr Ala Arg Gly Thr 
            100                 105                 110         

Leu Thr Tyr Ala Asn Val Glu Gly Ser Tyr Gly Val Arg Gln Ser Phe 
        115                 120                 125             

Gly Lys Asn Gln Asn Pro Ala Gly Trp Thr Gly Asn Pro Asn His Val 
    130                 135                 140                 

Lys Tyr Lys Ile Glu Trp Leu Asn Gly Leu Ser Tyr Val Gly Asp Phe 
145                 150                 155                 160 

Trp Asn Arg Ser His Leu Ile Ala Asp Ser Leu Gly Gly Asp Ala Leu 
                165                 170                 175     

Arg Val Asn Ala Val Thr Gly Thr Arg Thr Gln Asn Val Gly Gly Arg 
            180                 185                 190         

Asp Gln Lys Gly Gly Met Arg Tyr Thr Glu Gln Arg Ala Gln Glu Trp 
        195                 200                 205             

Leu Glu Ala Asn Arg Asp Gly Tyr Leu Tyr Tyr Glu Ala Ala Pro Ile 
    210                 215                 220                 

Tyr Asn Ala Asp Glu Leu Ile Pro Arg Ala Val Val Val Ser Met Gln 
225                 230                 235                 240 

Ser Ser Asp Asn Thr Ile Asn Glu Lys Val Leu Val Tyr Asn Thr Ala 
                245                 250                 255     

Asn Gly Tyr Thr Ile Asn Tyr His Asn Gly Thr Pro Thr Gln Lys 
            260                 265                 270     

<210>   41
<211>   310
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (21)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   41
Met Gly Lys Arg Met Ser Leu Ile Leu Gly Ala Phe Leu Ser Val Phe 
1               5                   10                  15      

Leu Leu Val Ala Cys Ser Ser Thr Gly Thr Lys Thr Ala Lys Ser Asp 
            20                  25                  30          

Lys Leu Lys Val Val Ala Thr Asn Ser Ile Ile Ala Asp Met Thr Lys 
        35                  40                  45              

Ala Ile Ala Gly Asp Lys Ile Asp Leu His Ser Ile Val Pro Ile Gly 
    50                  55                  60                  

Gln Asp Pro His Glu Tyr Glu Pro Leu Pro Glu Asp Val Glu Lys Thr 
65                  70                  75                  80  

Ser Asn Ala Asp Val Ile Phe Tyr Asn Gly Ile Asn Leu Glu Asp Gly 
                85                  90                  95      

Gly Gln Ala Trp Phe Thr Lys Leu Val Lys Asn Ala Gln Lys Thr Lys 
            100                 105                 110         

Asn Lys Asp Tyr Phe Ala Val Ser Asp Gly Ile Asp Val Ile Tyr Leu 
        115                 120                 125             

Glu Gly Ala Ser Glu Lys Gly Lys Glu Asp Pro His Ala Trp Leu Asn 
    130                 135                 140                 

Leu Glu Asn Gly Ile Ile Tyr Ser Lys Asn Ile Ala Lys Gln Leu Ile 
145                 150                 155                 160 

Ala Lys Asp Pro Lys Asn Lys Glu Thr Tyr Glu Lys Asn Leu Lys Ala 
                165                 170                 175     

Tyr Val Ala Lys Leu Glu Lys Leu Asp Lys Glu Ala Lys Ser Lys Phe 
            180                 185                 190         

Asp Ala Ile Ala Glu Asn Lys Lys Leu Ile Val Thr Ser Glu Gly Cys 
        195                 200                 205             

Phe Lys Tyr Phe Ser Lys Ala Tyr Gly Val Pro Ser Ala Tyr Ile Trp 
    210                 215                 220                 

Glu Ile Asn Thr Glu Glu Glu Gly Thr Pro Asp Gln Ile Ser Ser Leu 
225                 230                 235                 240 

Ile Glu Lys Leu Lys Val Ile Lys Pro Ser Ala Leu Phe Val Glu Ser 
                245                 250                 255     

Ser Val Asp Arg Arg Pro Met Glu Thr Val Ser Lys Asp Ser Gly Ile 
            260                 265                 270         

Pro Ile Tyr Ser Glu Ile Phe Thr Asp Ser Ile Ala Lys Lys Gly Lys 
        275                 280                 285             

Pro Gly Asp Ser Tyr Tyr Ala Met Met Lys Trp Asn Leu Asp Lys Ile 
    290                 295                 300                 

Ser Glu Gly Leu Ala Lys 
305                 310 

<210>   42
<211>   235
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (24)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   42
Met Thr Lys Lys Lys Gly Lys Leu Val Leu Ile Ser Leu Phe Val Leu 
1               5                   10                  15      

Ala Ala Cys Leu Gly Ala Tyr Ser Ala Met Arg Gln Ser His Lys Thr 
            20                  25                  30          

Ser Asn Val Ser Ala Glu Thr Ile Ala Ser Ser Ser Thr Arg His Phe 
        35                  40                  45              

Ile Asp Glu Ile Gly Pro Thr Ala Ser Thr Ile Gly Gln Glu Arg Asp 
    50                  55                  60                  

Leu Tyr Ala Ser Val Met Ile Ala Gln Ala Ile Leu Glu Ser Ser Asn 
65                  70                  75                  80  

Gly Lys Ser Ser Leu Ser Gln Ala Pro Tyr Tyr Asn Phe Phe Gly Ile 
                85                  90                  95      

Lys Gly Ala Tyr Asn Gly Ser Ser Val Thr Met Ser Thr Trp Glu Asp 
            100                 105                 110         

Asp Gly Asn Gly Asn Thr Tyr Thr Ile Asp Gln Ala Phe Arg Ala Tyr 
        115                 120                 125             

Pro Ser Ile Ala Asp Ser Leu Asn Asp Tyr Ala Asp Leu Leu Ser Ser 
    130                 135                 140                 

Ser Thr Tyr Ile Gly Ala Arg Lys Ser Asn Thr Leu Ser Tyr Gln Asp 
145                 150                 155                 160 

Ala Thr Ala Ala Leu Thr Gly Leu Tyr Ala Thr Asp Thr Ser Tyr Asn 
                165                 170                 175     

Leu Lys Leu Asn Asn Ile Ile Ala Thr Tyr Gly Leu Thr Ala Tyr Asp 
            180                 185                 190         

Val Ala Asn Ser Ser Ala Gln Glu Thr Gly Leu Ala Thr Ser Gly Tyr 
        195                 200                 205             

Val Trp Asn Glu Tyr Arg Arg Asn Tyr Thr Asp Ala Glu Thr Leu Ala 
    210                 215                 220                 

Val Asp Glu Ala Trp Ala Lys Arg Met Thr Tyr 
225                 230                 235 

<210>   43
<211>   225
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   43
Met Ser Ser Val Gly Val Ile Asn Leu Arg Asn Leu Tyr Ser Thr Tyr 
1               5                   10                  15      

Asp Pro Thr Glu Val Lys Gly Lys Ile Asn Glu Gly Pro Pro Phe Ser 
            20                  25                  30          

Gly Ser Leu Phe Tyr Lys Asn Ile Pro Tyr Gly Asn Ser Ser Ile Glu 
        35                  40                  45              

Leu Lys Val Glu Leu Asn Ser Val Glu Lys Ala Asn Phe Phe Ser Gly 
    50                  55                  60                  

Lys Arg Val Asp Ile Phe Thr Leu Glu Tyr Ser Pro Pro Cys Asn Ser 
65                  70                  75                  80  

Asn Ile Lys Lys Asn Ser Tyr Gly Gly Ile Thr Leu Ser Asp Gly Asn 
                85                  90                  95      

Arg Ile Asp Lys Lys Asn Ile Pro Val Asn Ile Phe Ile Asp Gly Val 
            100                 105                 110         

Gln Gln Lys Tyr Ser Tyr Thr Asp Ile Ser Thr Gly Ser Thr Asp Lys 
        115                 120                 125             

Lys Glu Val Thr Ile Gln Glu Leu Asp Val Lys Ser Arg Tyr Tyr Leu 
    130                 135                 140                 

Gln Lys His Phe Asn Ile Tyr Gly Phe Gly Asp Val Lys Asp Phe Gly 
145                 150                 155                 160 

Arg Ser Ser Arg Phe Gln Ser Gly Phe Glu Glu Gly Asn Ile Ile Phe 
                165                 170                 175     

His Leu Asn Ser Gly Glu Arg Ile Ser Tyr Asn Leu Phe Asp Thr Gly 
            180                 185                 190         

His Gly Asp Arg Glu Ser Met Leu Lys Lys Tyr Ser Asp Asn Lys Thr 
        195                 200                 205             

Ala Tyr Ser Asp Gln Leu His Ile Asp Ile Tyr Leu Val Lys Phe Asn 
    210                 215                 220                 

Lys 
225 

<210>   44
<211>   419
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (24)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   44
Met Ser Trp Asn Trp Lys Lys Thr Ser Val Leu Gly Thr Leu Ser Leu 
1               5                   10                  15      

Ala Ser Val Leu Pro Leu Thr Ala Cys Val Ser Gly Gly Gly Lys Gly 
            20                  25                  30          

Val Lys Glu Thr Asp Gly Lys Thr Ile Val Val Ser Val Asp Glu Gly 
        35                  40                  45              

Tyr Val Asp Tyr Ile Lys Ser Ile Lys Gly Glu Phe Glu Lys Glu His 
    50                  55                  60                  

Lys Val Thr Val Lys Val Lys Lys Glu Gly Met Met Asp Thr Leu Asp 
65                  70                  75                  80  

Lys Leu Ser Thr Asp Gly Pro Thr Gly Ala Ser Pro Asp Val Phe Leu 
                85                  90                  95      

Ala Pro Phe Asp Arg Val Gly Gly Leu Gly Thr Glu Gly Gln Ile Ala 
            100                 105                 110         

Glu Val Thr Leu Gly Asn Ser Lys Glu Phe Asp Asp Thr Val Lys Lys 
        115                 120                 125             

Leu Val Thr Ile Asp Gly Lys Thr Tyr Gly Ala Pro Asp Val Ile Glu 
    130                 135                 140                 

Thr Leu Val Thr Tyr Tyr Asn Lys Asp Leu Val Pro Gln Ala Pro Lys 
145                 150                 155                 160 

Ser Phe Thr Glu Leu Glu Val Leu Gln Lys Asp Ser Lys Phe Ala Phe 
                165                 170                 175     

Ala Ser Glu Pro Gly Lys Ser Val Gly Phe Leu Ala Lys Trp Thr Asp 
            180                 185                 190         

Phe Tyr Tyr Gly Tyr Gly Leu Ile Ala Gly Tyr Gly Gly Tyr Ile Phe 
        195                 200                 205             

Gly Asp Lys Gly Thr Lys Pro Ser Asp Leu Gly Leu Gly Asn Asp Gly 
    210                 215                 220                 

Thr Val Glu Gly Leu Asn Tyr Ala Lys Gln Trp Tyr Gly Thr Trp Pro 
225                 230                 235                 240 

Gln Gly Met Gln Asp Thr Lys Lys Ala Gly Asp Phe Ile Thr Glu Gln 
                245                 250                 255     

Phe Ile Ser Lys Lys Ala Gly Val Ile Ile Asp Gly Pro Trp Ala Ala 
            260                 265                 270         

Ser Ser Phe Lys Asp Ala Gly Val Asn Phe Gly Val Met Glu Ile Pro 
        275                 280                 285             

Thr Leu Thr Asn Gly Lys Lys Tyr Gln Pro Phe Ala Gly Gly Lys Ala 
    290                 295                 300                 

Trp Val Ile Ser Asn Tyr Ser Lys Gly Lys Thr Thr Ala Gln Lys Phe 
305                 310                 315                 320 

Leu Asp Tyr Val Thr Asn Ala Glu Asn Gln Lys Arg Phe Tyr Asp Lys 
                325                 330                 335     

Thr Gln Glu Ile Pro Ala Asn Leu Thr Ala Arg Asn Tyr Ala Ser Lys 
            340                 345                 350         

Glu Gly Asn Glu Leu Thr Lys Ala Val Ile Ser Gln Phe Glu Ser Ala 
        355                 360                 365             

Gln Pro Met Pro Asn Ile Pro Glu Met Ala Glu Val Trp Glu Pro Gly 
    370                 375                 380                 

Ala Asn Met Phe Phe Asn Val Ala Ser Gly Lys Glu Glu Ala Ser Lys 
385                 390                 395                 400 

Ala Ala Lys Glu Ala Ala Lys Thr Ile Lys Glu Ala Ile Glu Gln Lys 
                405                 410                 415     

Tyr Ala Glu 
            

<210>   45
<211>   265
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (31)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   45
Met Thr Thr Met Gln Lys Thr Ile Ser Leu Leu Ser Leu Ala Leu Leu 
1               5                   10                  15      

Ile Gly Leu Leu Gly Thr Ser Gly Lys Ala Ile Ser Val Tyr Ala Gln 
            20                  25                  30          

Asp Gln His Thr Asp Asn Val Ile Ala Glu Ser Thr Ile Ser Gln Val 
        35                  40                  45              

Ser Val Glu Ala Ser Met Arg Gly Thr Glu Pro Tyr Ile Asp Ala Thr 
    50                  55                  60                  

Val Thr Thr Asp Gln Pro Val Arg Gln Pro Thr Gln Ala Thr Ile Thr 
65                  70                  75                  80  

Leu Lys Asp Ala Ser Asp Asn Thr Ile Asn Ser Trp Val Tyr Thr Met 
                85                  90                  95      

Ala Ala Gln Gln Arg Arg Phe Thr Ala Trp Phe Asp Leu Thr Gly Gln 
            100                 105                 110         

Lys Ser Gly Asp Tyr His Val Thr Val Thr Val His Thr Gln Glu Lys 
        115                 120                 125             

Ala Val Thr Gly Gln Ser Gly Thr Val His Phe Asp Gln Asn Lys Ala 
    130                 135                 140                 

Arg Lys Thr Pro Thr Asn Met Gln Gln Lys Asp Thr Ser Lys Ala Met 
145                 150                 155                 160 

Thr Asn Ser Val Asp Val Asp Thr Lys Ala Gln Thr Asn Gln Ser Ala 
                165                 170                 175     

Asn Gln Glu Ile Asp Ser Thr Ser Asn Pro Phe Arg Ser Ala Thr Asn 
            180                 185                 190         

His Arg Ser Thr Ser Leu Lys Arg Ser Thr Lys Asn Glu Lys Leu Thr 
        195                 200                 205             

Pro Thr Ala Ser Asn Ser Gln Lys Asn Gly Ser Asn Lys Thr Lys Met 
    210                 215                 220                 

Leu Val Asp Lys Glu Glu Val Lys Pro Thr Ser Lys Arg Gly Phe Pro 
225                 230                 235                 240 

Trp Val Leu Leu Gly Leu Val Val Ser Leu Ala Ala Gly Leu Phe Ile 
                245                 250                 255     

Ala Ile Gln Lys Val Ser Arg Arg Lys 
            260                 265 

<210>   46
<211>   995
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (25)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   46
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      

Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          

Thr Val Lys Ala Glu Glu Lys Thr Val Gln Val Gln Lys Gly Leu Pro 
        35                  40                  45              

Ser Ile Asp Ser Leu His Tyr Leu Ser Glu Asn Ser Lys Lys Glu Phe 
    50                  55                  60                  

Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu Ser Gln Lys Val Lys Glu 
65                  70                  75                  80  

Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu Leu Ala 
                85                  90                  95      

Lys Met Lys Ile Pro Glu Lys Ile Pro Met Lys Pro Leu His Gly Ser 
            100                 105                 110         

Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His Asp Lys Thr Ser Asp Pro 
        115                 120                 125             

Thr Glu Lys Asp Lys Val Asn Ser Met Gly Glu Leu Pro Lys Glu Val 
    130                 135                 140                 

Asp Leu Ala Phe Ile Phe His Asp Trp Thr Lys Asp Tyr Ser Leu Phe 
145                 150                 155                 160 

Trp Lys Glu Leu Ala Thr Lys His Val Pro Lys Leu Asn Lys Gln Gly 
                165                 170                 175     

Thr Arg Val Ile Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly Gly Asp 
            180                 185                 190         

Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr Pro Glu 
        195                 200                 205             

Gly Asn Lys Ala Leu Ala Lys Ala Ile Val Asp Glu Tyr Val Tyr Lys 
    210                 215                 220                 

Tyr Asn Leu Asp Gly Leu Asp Val Asp Val Glu His Asp Ser Ile Pro 
225                 230                 235                 240 

Lys Val Asp Lys Lys Glu Asp Thr Ala Gly Val Glu Arg Ser Ile Gln 
                245                 250                 255     

Val Phe Glu Glu Ile Gly Lys Leu Ile Gly Pro Lys Gly Val Asp Lys 
            260                 265                 270         

Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr Met Ala Asp Lys Asn Pro 
        275                 280                 285             

Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val Gln Val 
    290                 295                 300                 

Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp Glu Pro Val Ser Asn Arg 
305                 310                 315                 320 

Pro Glu Lys Thr Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys Tyr Ile 
                325                 330                 335     

Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu Asn Ala 
            340                 345                 350         

Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp Glu Asp 
        355                 360                 365             

Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala Glu Arg 
    370                 375                 380                 

Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly Val Lys Gly Gly Ile Phe 
385                 390                 395                 400 

Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Gln Pro Lys Lys Tyr 
                405                 410                 415     

Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe His Ser 
            420                 425                 430         

Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr Val Met Leu Lys Asp Lys 
        435                 440                 445             

Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala Leu Arg 
    450                 455                 460                 

Glu Ala Val Met Ala Gln Val Gly Thr Arg Lys Gly Asp Leu Glu Arg 
465                 470                 475                 480 

Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser Leu Glu 
                485                 490                 495     

Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile Gly Leu 
            500                 505                 510         

Ser Arg Ile Thr Lys Leu Asp Arg Ser Val Leu Pro Ala Asn Met Lys 
        515                 520                 525             

Pro Gly Lys Asp Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys Lys Asp 
    530                 535                 540                 

Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro Val Ser Leu Lys Val Ser 
545                 550                 555                 560 

Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp Arg Glu 
                565                 570                 575     

Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu Lys Val 
            580                 585                 590         

Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu Asn Arg 
        595                 600                 605             

Gln Ile Phe Asp Thr Met Leu Ser Thr Ile Ser Asn His Val Gly Ser 
    610                 615                 620                 

Asn Glu Gln Thr Val Lys Phe Asp Lys Gln Lys Pro Thr Gly His Tyr 
625                 630                 635                 640 

Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg Leu Pro Val Ala Asn Glu 
                645                 650                 655     

Lys Val Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr Asn Gln 
            660                 665                 670         

Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln Asn His 
        675                 680                 685             

Lys Ile Ala Gly Arg Ser Phe Val Asp Ser Asn Tyr His Tyr Asn Asn 
    690                 695                 700                 

Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp Ser Thr 
705                 710                 715                 720 

Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu Glu Thr 
                725                 730                 735     

Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala Val His 
            740                 745                 750         

Thr Ala Lys Val Ile Val Gly Asp Glu Lys Thr Met Met Val Asn Leu 
        755                 760                 765             

Ala Glu Gly Ala Thr Val Ile Gly Gly Ser Ala Asp Pro Val Asn Ala 
    770                 775                 780                 

Arg Lys Val Phe Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn Ile Ser 
785                 790                 795                 800 

Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys Glu Asp 
                805                 810                 815     

Gly Leu Ile Lys His Trp Arg Phe Phe Asn Asp Ser Ala Arg Asn Pro 
            820                 825                 830         

Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile Phe Asn 
        835                 840                 845             

Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn Lys Phe 
    850                 855                 860                 

Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala Gln Gly 
865                 870                 875                 880 

Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr Ser Lys 
                885                 890                 895     

Tyr Trp Arg Val Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser Ser Pro 
            900                 905                 910         

Val Val Pro Glu Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn Ala Asp 
        915                 920                 925             

Thr Ile Met Lys Thr Val Thr Thr Ala Lys Glu Leu Ser Gln Gln Lys 
    930                 935                 940                 

Asp Lys Phe Ser Gln Lys Met Leu Asp Glu Leu Lys Ile Lys Glu Met 
945                 950                 955                 960 

Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile Phe Asp Val Thr Ala Ile 
                965                 970                 975     

Asn Ala Asn Ala Gly Val Leu Lys Asp Cys Ile Glu Lys Arg Gln Leu 
            980                 985                 990         

Leu Lys Lys 
        995 

<210>   47
<211>   824
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (393)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   47
Met Ile Lys Asp Thr Phe Leu Lys Thr Asn Trp Leu Asn Ile Ser His 
1               5                   10                  15      

His Ile Ile Leu Leu Val Phe Gly Phe Tyr Phe Ser Phe Tyr Ser Leu 
            20                  25                  30          

Ala Lys Glu Leu Val Ser Ser Thr Ala Gln Pro Val Asn Tyr Tyr Ala 
        35                  40                  45              

His Leu Leu Asn Val Ser Phe Val Gly Tyr Ile Ile Ser Leu Ile Gly 
    50                  55                  60                  

Leu Ser Tyr Tyr Leu Ser Arg Gln Val Ser Arg Gln Leu Phe Leu Lys 
65                  70                  75                  80  

Thr Ser Phe Ile Val Ile Ser Tyr Leu Ile Val Ser Tyr Trp Val Gln 
                85                  90                  95      

Ile Thr Gln His Leu Asn Asp Lys Arg Phe Asp Ile Trp Ser Leu Thr 
            100                 105                 110         

Lys Asn Gln Phe Tyr Gln Phe Gln Ala Leu Pro Ser Leu Leu Ile Ile 
        115                 120                 125             

Leu Val Met Ala Thr Leu Ile Lys Ile Leu Ala Ala Tyr Phe Ala Ile 
    130                 135                 140                 

Glu Lys Asp Arg Phe Gly Leu Leu Gly Tyr Gln Gly Asn Thr Phe Ser 
145                 150                 155                 160 

Val Ala Leu Ile Leu Ala Val Val Pro Ile Asn Asp Ile His Leu Leu 
                165                 170                 175     

Lys Leu Ile Ser Ser Arg Phe Ser Glu Leu Val Thr Ala Gly Asn Ser 
            180                 185                 190         

Gln Ile Ala Leu Leu Lys Ile Ser Gly Leu Leu Ile Val Leu Leu Val 
        195                 200                 205             

Ile Phe Ala Thr Ile Ile Tyr Val Val Leu Asn Ala Leu Lys His Leu 
    210                 215                 220                 

Lys Ser Asn Lys Pro Ser Phe Ser Val Ala Ala Thr Thr Ser Leu Phe 
225                 230                 235                 240 

Leu Ala Leu Val Phe Asn Tyr Thr Phe Gln Tyr Gly Val Lys Gly Asp 
                245                 250                 255     

Glu Ala Leu Leu Gly Tyr Tyr Val Phe Pro Gly Ala Thr Leu Phe Gln 
            260                 265                 270         

Ile Val Ala Ile Thr Leu Val Ala Leu Leu Ala Tyr Val Ile Thr Asn 
        275                 280                 285             

Arg Tyr Trp Pro Thr Thr Phe Phe Leu Leu Ile Leu Gly Thr Ile Ile 
    290                 295                 300                 

Ser Val Val Asn Asp Leu Lys Glu Ser Met Arg Ser Glu Pro Leu Leu 
305                 310                 315                 320 

Val Thr Asp Phe Val Trp Leu Gln Glu Leu Gly Leu Val Thr Ser Phe 
                325                 330                 335     

Val Lys Lys Ser Val Ile Val Glu Met Val Val Gly Leu Ala Ile Cys 
            340                 345                 350         

Ile Val Val Ala Trp Tyr Leu His Gly Arg Val Leu Ala Gly Lys Leu 
        355                 360                 365             

Phe Met Ser Pro Val Lys Arg Ala Ser Ala Val Leu Gly Leu Phe Ile 
    370                 375                 380                 

Val Ser Cys Ser Met Leu Ile Pro Phe Ser Tyr Glu Lys Glu Gly Lys 
385                 390                 395                 400 

Ile Leu Ser Gly Leu Pro Ile Ile Ser Ala Leu Asn Asn Asp Asn Asp 
                405                 410                 415     

Ile Asn Trp Leu Gly Phe Ser Thr Asn Ala Arg Tyr Lys Ser Leu Ala 
            420                 425                 430         

Tyr Val Trp Thr Arg Gln Val Thr Lys Lys Ile Met Glu Lys Pro Thr 
        435                 440                 445             

Asn Tyr Ser Gln Glu Thr Ile Ala Ser Ile Ala Gln Lys Tyr Gln Lys 
    450                 455                 460                 

Leu Ala Glu Asp Ile Asn Lys Asp Arg Lys Asn Asn Ile Ala Asp Gln 
465                 470                 475                 480 

Thr Val Ile Tyr Leu Leu Ser Glu Ser Leu Ser Asp Pro Asp Arg Val 
                485                 490                 495     

Ser Asn Val Thr Val Ser His Asp Val Leu Pro Asn Ile Lys Ala Ile 
            500                 505                 510         

Lys Asn Ser Thr Thr Ala Gly Leu Met Gln Ser Asp Ser Tyr Gly Gly 
        515                 520                 525             

Gly Thr Ala Asn Met Glu Phe Gln Thr Leu Thr Ser Leu Pro Phe Tyr 
    530                 535                 540                 

Asn Phe Ser Ser Ser Val Ser Val Leu Tyr Ser Glu Val Phe Pro Lys 
545                 550                 555                 560 

Met Ala Lys Pro His Thr Ile Ser Glu Phe Tyr Gln Gly Lys Asn Arg 
                565                 570                 575     

Ile Ala Met His Pro Ala Ser Ala Asn Asn Phe Asn Arg Lys Thr Val 
            580                 585                 590         

Tyr Ser Asn Leu Gly Phe Ser Lys Phe Leu Ala Leu Ser Gly Ser Lys 
        595                 600                 605             

Asp Lys Phe Lys Asn Ile Glu Asn Val Gly Leu Leu Thr Ser Asp Lys 
    610                 615                 620                 

Thr Val Tyr Asn Asn Ile Leu Ser Leu Ile Asn Pro Ser Glu Ser Gln 
625                 630                 635                 640 

Phe Phe Ser Val Ile Thr Met Gln Asn His Ile Pro Trp Ser Ser Asp 
                645                 650                 655     

Tyr Pro Glu Glu Ile Val Ala Glu Gly Lys Asn Phe Thr Glu Glu Glu 
            660                 665                 670         

Asn His Asn Leu Thr Ser Tyr Ala Arg Leu Leu Ser Phe Thr Asp Lys 
        675                 680                 685             

Glu Thr Arg Ala Phe Leu Glu Lys Leu Thr Gln Ile Asn Lys Pro Ile 
    690                 695                 700                 

Thr Val Val Phe Tyr Gly Asp His Leu Pro Gly Leu Tyr Pro Asp Ser 
705                 710                 715                 720 

Ala Phe Asn Lys His Ile Glu Asn Lys Tyr Leu Thr Asp Tyr Phe Ile 
                725                 730                 735     

Trp Ser Asn Gly Thr Asn Glu Lys Lys Asn His Pro Leu Ile Asn Ser 
            740                 745                 750         

Ser Asp Phe Thr Ala Ala Leu Phe Glu His Thr Asp Ser Lys Val Ser 
        755                 760                 765             

Pro Tyr Tyr Ala Leu Leu Thr Glu Val Leu Asn Lys Ala Ser Val Asp 
    770                 775                 780                 

Lys Ser Pro Asp Ser Pro Glu Val Lys Ala Ile Gln Asn Asp Leu Lys 
785                 790                 795                 800 

Asn Ile Gln Tyr Asp Val Thr Ile Gly Lys Gly Tyr Leu Leu Lys His 
                805                 810                 815     

Lys Thr Phe Phe Lys Ile Ser Arg 
            820                 

<210>   48
<211>   406
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1) ... (36)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (282) ... (406)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   48
Met Glu Asn Trp Lys Phe Ala Leu Ser Ser Ile Trp Gly His Lys Met 
1               5                   10                  15      

Arg Ser Ile Leu Thr Met Leu Gly Ile Ile Ile Gly Val Ala Ala Val 
            20                  25                  30          

Val Ile Ile Met Gly Leu Gly Asn Ala Met Lys Asn Ser Val Thr Ser 
        35                  40                  45              

Thr Phe Ser Ser Lys Gln Lys Asp Ile Gln Leu Tyr Phe Gln Glu Lys 
    50                  55                  60                  

Gly Glu Glu Glu Asp Leu Tyr Ala Gly Leu His Thr His Glu Asn Asn 
65                  70                  75                  80  

His Glu Val Lys Pro Glu Trp Leu Glu Gln Ile Val Lys Asp Ile Asp 
                85                  90                  95      

Gly Ile Asp Ser Tyr Tyr Phe Thr Asn Ser Ala Thr Ser Thr Ile Ser 
            100                 105                 110         

Tyr Glu Lys Lys Lys Val Asp Asn Ala Ser Ile Ile Gly Val Ser Lys 
        115                 120                 125             

Asp Tyr Phe Asn Ile Lys Asn Tyr Asp Ile Val Ala Gly Arg Thr Leu 
    130                 135                 140                 

Thr Asp Asn Asp Tyr Ser Asn Phe Ser Arg Ile Ile Leu Leu Asp Thr 
145                 150                 155                 160 

Val Leu Ala Asp Asp Leu Phe Gly Lys Gly Asn Tyr Lys Ser Ala Leu 
                165                 170                 175     

Asn Lys Val Val Ser Leu Ser Asp Lys Asp Tyr Leu Val Ile Gly Val 
            180                 185                 190         

Tyr Lys Thr Asp Gln Thr Pro Val Ser Phe Asp Gly Leu Ser Gly Gly 
        195                 200                 205             

Ala Val Met Ala Asn Thr Gln Val Ala Ser Glu Phe Gly Thr Lys Glu 
    210                 215                 220                 

Ile Gly Ser Ile Tyr Ile His Val Asn Asp Ile Gln Asn Ser Met Asn 
225                 230                 235                 240 

Leu Gly Asn Gln Ala Ala Asp Met Leu Thr Asn Ile Ser His Ile Lys 
                245                 250                 255     

Asp Gly Gln Tyr Ala Val Pro Asp Asn Ser Lys Ile Val Glu Glu Ile 
            260                 265                 270         

Asn Ser Gln Phe Ser Ile Met Thr Thr Val Ile Gly Ser Ile Ala Ala 
        275                 280                 285             

Ile Ser Leu Leu Val Gly Gly Ile Gly Val Met Asn Ile Met Leu Val 
    290                 295                 300                 

Ser Val Thr Glu Arg Thr Arg Glu Ile Gly Leu Arg Lys Ala Leu Gly 
305                 310                 315                 320 

Ala Thr Arg Leu Lys Ile Leu Ser Gln Phe Leu Ile Glu Ser Val Val 
                325                 330                 335     

Leu Thr Val Leu Gly Gly Leu Ile Gly Leu Leu Leu Ala Gln Leu Ser 
            340                 345                 350         

Val Gly Ala Leu Gly Asn Ala Met Thr Leu Lys Gly Ala Cys Ile Ser 
        355                 360                 365             

Leu Asp Val Ala Leu Ile Ala Val Leu Phe Ser Ala Ser Ile Gly Val 
    370                 375                 380                 

Phe Phe Gly Met Leu Pro Ala Asn Lys Ala Ser Lys Leu Asp Pro Ile 
385                 390                 395                 400 

Glu Ala Leu Arg Tyr Glu 
                405     

<210>   49
<211>   564
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (542) ... (564)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   49
Met Ala Lys Asn Thr Thr Asn Arg His Tyr Ser Leu Arg Lys Leu Lys 
1               5                   10                  15      

Thr Gly Thr Ala Ser Val Ala Val Ala Leu Thr Val Val Gly Ala Gly 
            20                  25                  30          

Leu Val Ala Gly Gln Thr Val Arg Ala Asp His Ser Asp Leu Val Ala 
        35                  40                  45              

Glu Lys Gln Arg Leu Glu Asp Leu Gly Gln Lys Phe Glu Arg Leu Lys 
    50                  55                  60                  

Gln Arg Ser Glu Leu Tyr Leu Gln Gln Tyr Tyr Asp Asn Lys Ser Asn 
65                  70                  75                  80  

Gly Tyr Lys Gly Asp Trp Tyr Val Gln Gln Leu Lys Met Leu Asn Arg 
                85                  90                  95      

Asp Leu Glu Gln Ala Tyr Asn Glu Leu Ser Gly Glu Ala His Lys Asp 
            100                 105                 110         

Ala Leu Gly Lys Leu Gly Ile Asp Asn Ala Asp Leu Lys Ala Lys Ile 
        115                 120                 125             

Thr Glu Leu Glu Lys Ser Val Glu Glu Lys Asn Asp Val Leu Ser Gln 
    130                 135                 140                 

Ile Lys Lys Glu Leu Glu Glu Ala Glu Lys Asp Ile Gln Phe Gly Arg 
145                 150                 155                 160 

Glu Val His Ala Ala Asp Leu Leu Arg His Lys Gln Glu Ile Ala Glu 
                165                 170                 175     

Lys Glu Asn Val Ile Ser Lys Leu Asn Gly Glu Leu Gln Pro Leu Lys 
            180                 185                 190         

Gln Lys Val Asp Glu Thr Asp Arg Asn Leu Gln Gln Glu Lys Gln Lys 
        195                 200                 205             

Val Leu Ser Leu Glu Gln Gln Leu Ala Val Thr Lys Glu Asn Ala Lys 
    210                 215                 220                 

Lys Asp Phe Glu Leu Ala Ala Leu Gly His Gln Leu Ala Asp Lys Glu 
225                 230                 235                 240 

Tyr Asn Ala Lys Ile Ala Glu Leu Glu Ser Lys Leu Ala Asp Ala Lys 
                245                 250                 255     

Lys Asp Phe Glu Leu Ala Ala Leu Gly His Gln His Ala His Asn Glu 
            260                 265                 270         

Tyr Gln Ala Lys Leu Ala Glu Lys Asp Gly Gln Ile Lys Gln Leu Glu 
        275                 280                 285             

Glu Gln Lys Gln Ile Leu Asp Ala Ser Arg Lys Gly Thr Ala Arg Asp 
    290                 295                 300                 

Leu Glu Ala Val Arg Gln Ala Lys Lys Ala Thr Glu Ala Glu Leu Asn 
305                 310                 315                 320 

Asn Leu Lys Ala Glu Leu Ala Lys Val Thr Glu Gln Lys Gln Ile Leu 
                325                 330                 335     

Asp Ala Ser Arg Lys Gly Thr Ala Arg Asp Leu Glu Ala Val Arg Lys 
            340                 345                 350         

Ser Lys Lys Gln Gln Val Glu Ala Ala Leu Lys Gln Leu Glu Glu Gln 
        355                 360                 365             

Asn Lys Ile Ser Glu Ala Ser Arg Lys Gly Leu Arg Arg Asp Leu Asp 
    370                 375                 380                 

Thr Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Asp Leu Ala Asn Leu 
385                 390                 395                 400 

Thr Ala Glu Leu Asp Lys Val Lys Glu Glu Lys Gln Ile Ser Asp Ala 
                405                 410                 415     

Ser Arg Gln Gly Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys 
            420                 425                 430         

Lys Gln Val Glu Lys Ala Leu Glu Glu Ala Asn Ser Lys Leu Ala Ala 
        435                 440                 445             

Leu Glu Lys Leu Asn Lys Asp Leu Glu Glu Ser Lys Lys Leu Thr Glu 
    450                 455                 460                 

Lys Glu Lys Ala Glu Leu Gln Ala Lys Leu Glu Ala Glu Ala Lys Ala 
465                 470                 475                 480 

Leu Lys Glu Gln Leu Ala Lys Gln Ala Glu Glu Leu Ala Lys Leu Arg 
                485                 490                 495     

Ala Gly Lys Ala Ser Asp Ser Gln Thr Pro Asp Ala Lys Pro Gly Asn 
            500                 505                 510         

Lys Ala Val Pro Gly Lys Gly Gln Ala Pro Gln Ala Gly Thr Lys Pro 
        515                 520                 525             

Asn Gln Asn Lys Ala Pro Met Lys Glu Thr Lys Arg Gln Leu Pro Ser 
    530                 535                 540                 

Thr Gly Glu Thr Ala Asn Pro Phe Phe Thr Ala Ala Ala Leu Thr Val 
545                 550                 555                 560 

Met Ala Ala Ala 
                

<210>   50
<211>   500
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (466) ... (500)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   50
Met Ala Lys Asn Asn Thr Asn Arg His Tyr Ser Leu Arg Lys Leu Lys 
1               5                   10                  15      

Thr Gly Thr Ala Ser Val Ala Val Ala Leu Thr Val Leu Gly Thr Gly 
            20                  25                  30          

Leu Ala Ser Gln Thr Glu Val Lys Ala Asp Gly Glu Ala Arg Asp Val 
        35                  40                  45              

Val Pro Glu Leu Val Ala Asn Asn Leu Gly Leu Leu Arg Lys Arg Val 
    50                  55                  60                  

Ala Arg Leu Gln Ala Glu Leu Lys Thr Lys Glu Glu Lys Leu Arg Lys 
65                  70                  75                  80  

Leu Asp Leu Ala Leu Gly Lys Glu His Ile Asp Asn Ile Ala Leu Lys 
                85                  90                  95      

His Gln Leu Glu Thr Glu Lys Arg Glu Ala Glu Ala Gln Arg Gln Ile 
            100                 105                 110         

Leu Glu Asn Glu Lys Lys Lys Leu Glu Glu Glu Leu Ala Asn Lys Asn 
        115                 120                 125             

Thr Thr Leu Asp Gly Ala Leu Arg Ala Ile Thr Glu Lys Glu Glu Lys 
    130                 135                 140                 

Leu Arg Glu Leu Asp Leu Ala Leu Gly Lys Glu His Ile Asp Asn Ile 
145                 150                 155                 160 

Asp Leu Lys His Gln Leu Glu Thr Glu Lys Arg Glu Ala Glu Ala Gln 
                165                 170                 175     

Arg Gln Ile Leu Glu Asn Glu Lys Lys Lys Leu Glu Glu Glu Leu Ala 
            180                 185                 190         

Asn Lys Asn Thr Thr Leu Asp Gly Ala Leu Arg Ala Ile Thr Glu Lys 
        195                 200                 205             

Glu Glu Lys Leu Arg Glu Leu Asp Leu Ala Leu Gly Lys Glu His Ile 
    210                 215                 220                 

Asp Asn Ile Asp Leu Lys His Gln Leu Glu Thr Glu Lys Arg Glu Ala 
225                 230                 235                 240 

Glu Ala Gln Arg Gln Ile Leu Glu Asn Glu Lys Lys Lys Leu Glu Glu 
                245                 250                 255     

Gln Asn Lys Ile Ser Glu Ala Ser Arg Lys Gly Leu Arg Arg Asp Leu 
            260                 265                 270         

Asp Ala Ser Arg Glu Ala Lys Lys Gln Leu Glu Ala Glu His Gln Lys 
        275                 280                 285             

Leu Glu Glu Gln Asn Lys Ile Ser Glu Ala Ser Arg Lys Gly Leu Arg 
    290                 295                 300                 

Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Asp 
305                 310                 315                 320 

Leu Ala Asn Leu Thr Ala Glu Leu Asp Lys Val Lys Glu Glu Lys Gln 
                325                 330                 335     

Ile Ser Asp Ala Ser Arg Gln Gly Leu Arg Arg Asp Leu Asp Ala Ser 
            340                 345                 350         

Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu Glu Glu Ala Asn Ser 
        355                 360                 365             

Lys Leu Ala Ala Leu Glu Lys Leu Asn Lys Glu Leu Glu Glu Ser Lys 
    370                 375                 380                 

Lys Leu Thr Glu Lys Glu Lys Ala Glu Leu Gln Ala Lys Leu Glu Ala 
385                 390                 395                 400 

Glu Ala Lys Ala Leu Lys Glu Gln Leu Ala Lys Gln Ala Glu Glu Leu 
                405                 410                 415     

Ala Lys Leu Arg Ala Gly Lys Ala Ser Gly Ser Gln Thr Pro Asp Ala 
            420                 425                 430         

Lys Pro Gly Asn Lys Ala Val Pro Gly Lys Gly Gln Ala Pro Gln Ala 
        435                 440                 445             

Gly Ala Lys Pro Asn Gln Asn Lys Ala Pro Met Lys Glu Thr Lys Arg 
    450                 455                 460                 

Gln Leu Pro Ser Thr Gly Glu Thr Ala Asn Pro Phe Leu Thr Ala Ala 
465                 470                 475                 480 

Ala Leu Thr Val Met Ala Thr Ala Gly Val Ala Ala Val Val Lys Arg 
                485                 490                 495     

Lys Glu Glu Asn 
            500 

<210>   51
<211>   337
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (304) ... (337)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   51
Met Ala Arg Lys Asp Thr Asn Lys Gln Tyr Ser Leu Arg Lys Leu Lys 
1               5                   10                  15      

Thr Gly Thr Ala Ser Val Ala Val Ala Val Ala Val Leu Gly Ala Gly 
            20                  25                  30          

Phe Ala Asn Gln Thr Thr Val Lys Ala Asn Ser Lys Asn Pro Val Pro 
        35                  40                  45              

Val Lys Lys Glu Ala Lys Leu Ser Glu Ala Glu Leu His Asp Lys Ile 
    50                  55                  60                  

Lys Asn Leu Glu Glu Glu Lys Ala Glu Leu Phe Glu Lys Leu Asp Lys 
65                  70                  75                  80  

Val Glu Glu Glu His Lys Lys Val Glu Glu Glu His Lys Lys Asp His 
                85                  90                  95      

Glu Lys Leu Glu Lys Lys Ser Glu Asp Val Glu Arg His Tyr Leu Arg 
            100                 105                 110         

Gln Leu Asp Gln Glu Tyr Lys Glu Gln Gln Glu Arg Gln Lys Asn Leu 
        115                 120                 125             

Glu Glu Leu Glu Arg Gln Ser Gln Arg Glu Val Glu Lys Arg Tyr Gln 
    130                 135                 140                 

Glu Gln Leu Gln Lys Gln Gln Gln Leu Glu Lys Glu Lys Gln Ile Ser 
145                 150                 155                 160 

Glu Ala Ser Arg Lys Ser Leu Ser Arg Asp Leu Glu Ala Ser Arg Ala 
                165                 170                 175     

Ala Lys Lys Asp Leu Glu Ala Glu His Gln Lys Leu Lys Glu Glu Lys 
            180                 185                 190         

Gln Ile Ser Glu Ala Ser Arg Gln Gly Leu Ser Arg Asp Leu Glu Ala 
        195                 200                 205             

Ser Arg Glu Ala Lys Lys Lys Val Glu Ala Asp Leu Ala Glu Ala Asn 
    210                 215                 220                 

Ser Lys Leu Gln Ala Leu Glu Lys Leu Asn Lys Glu Leu Glu Glu Gly 
225                 230                 235                 240 

Lys Lys Leu Ser Glu Lys Glu Lys Ala Glu Leu Gln Ala Lys Leu Glu 
                245                 250                 255     

Ala Glu Ala Lys Ala Leu Lys Glu Gln Leu Ala Lys Gln Ala Glu Glu 
            260                 265                 270         

Leu Ala Lys Leu Lys Gly Asn Gln Thr Pro Asn Ala Lys Val Ala Pro 
        275                 280                 285             

Gln Ala Asn Arg Ser Arg Ser Ala Met Thr Gln Gln Lys Arg Thr Leu 
    290                 295                 300                 

Pro Ser Thr Gly Glu Thr Ala Asn Pro Phe Phe Thr Ala Ala Ala Ala 
305                 310                 315                 320 

Thr Val Met Val Ser Ala Gly Met Leu Ala Leu Lys Arg Lys Glu Glu 
                325                 330                 335     

Asn 
    

<210>   52
<211>   581
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (547) ... (581)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   52
Met Ala Lys Asn Asn Thr Asn Arg His Tyr Ser Leu Arg Lys Leu Lys 
1               5                   10                  15      

Thr Gly Thr Ala Ser Val Ala Val Ala Leu Thr Val Leu Gly Thr Gly 
            20                  25                  30          

Leu Val Ala Gly Gln Thr Val Lys Ala Asp Ala Arg Ser Val Asn Gly 
        35                  40                  45              

Glu Phe Pro Arg His Val Lys Leu Lys Asn Glu Ile Glu Asn Leu Leu 
    50                  55                  60                  

Asp Gln Val Thr Gln Leu Tyr Thr Lys His Asn Ser Asn Tyr Gln Gln 
65                  70                  75                  80  

Tyr Asn Ala Gln Ala Gly Arg Leu Asp Leu Arg Gln Lys Ala Glu Tyr 
                85                  90                  95      

Leu Lys Gly Leu Asn Asp Trp Ala Glu Arg Leu Leu Gln Glu Leu Asn 
            100                 105                 110         

Gly Glu Asp Val Lys Lys Val Leu Gly Lys Val Ala Phe Glu Lys Asp 
        115                 120                 125             

Asp Leu Glu Lys Glu Val Lys Glu Leu Lys Glu Lys Ile Asp Lys Lys 
    130                 135                 140                 

Glu Lys Glu Tyr Gln Asp Leu Asp Lys Asp Phe Asp Leu Ala Lys Gln 
145                 150                 155                 160 

Gly Tyr Val Leu Ser Asp Lys Arg His Gln Gln Glu Leu Glu Glu Lys 
                165                 170                 175     

Glu Lys Lys Val Thr Glu Ala Thr Ala Lys Val Gly Gln Ile Ser Glu 
            180                 185                 190         

Glu Leu Glu Thr Val Lys Gln Lys Val Glu Ser Thr Met Gln Asp Leu 
        195                 200                 205             

Thr Glu Lys Gln Asn Arg Val Ser Gln Leu Glu Gln Glu Leu Ala Thr 
    210                 215                 220                 

Thr Lys Gln Asn Ala Lys Glu Asp Phe Glu Leu Ala Ala Leu Ala Asn 
225                 230                 235                 240 

Ala Ala Asp Lys Gln Lys Leu Glu Ala Lys Ile Ala Asp Leu Glu Thr 
                245                 250                 255     

Lys Leu Lys Glu Ala Lys Glu Asp Phe Glu Leu Ala Ala Leu Gly His 
            260                 265                 270         

Gln His Ala His Asn Glu Tyr Gln Ala Lys Leu Ala Glu Lys Asp Asp 
        275                 280                 285             

Gln Ile Lys Gln Leu Glu Glu Gln Lys Gln Ile Leu Asp Ala Ser Arg 
    290                 295                 300                 

Lys Gly Thr Ala Arg Asp Leu Glu Ala Val Arg Gln Ala Lys Lys Ala 
305                 310                 315                 320 

Thr Glu Ala Glu Leu Asn Asn Leu Lys Ala Glu Leu Ala Lys Val Thr 
                325                 330                 335     

Glu Gln Lys Gln Ile Leu Asp Ala Ser Arg Lys Gly Thr Ala Arg Asp 
            340                 345                 350         

Leu Glu Ala Val Arg Gln Ala Lys Ala Gln Val Glu Ala Ala Leu Lys 
        355                 360                 365             

Gln Leu Glu Glu Gln Asn Arg Ile Ser Glu Ala Ser Arg Lys Gly Leu 
    370                 375                 380                 

Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln Val Glu Lys 
385                 390                 395                 400 

Asp Leu Ala Asn Leu Thr Ala Glu Leu Asp Lys Val Lys Glu Glu Lys 
                405                 410                 415     

Gln Ile Ser Asp Ala Ser Arg Gln Gly Leu Arg Arg Asp Leu Asp Ala 
            420                 425                 430         

Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu Glu Glu Ala Asn 
        435                 440                 445             

Ser Lys Leu Ala Ala Leu Glu Lys Leu Asn Lys Glu Leu Glu Glu Ser 
    450                 455                 460                 

Lys Lys Leu Thr Glu Lys Glu Lys Ala Glu Leu Gln Ala Lys Leu Glu 
465                 470                 475                 480 

Ala Glu Ala Lys Ala Leu Lys Glu Gln Leu Ala Lys Gln Ala Glu Glu 
                485                 490                 495     

Leu Ala Lys Leu Arg Ala Gly Lys Ala Ser Asp Ser Gln Ile Pro Asp 
            500                 505                 510         

Thr Lys Pro Gly Asn Lys Ala Val Pro Gly Lys Gly Gln Ala Pro Gln 
        515                 520                 525             

Ala Gly Thr Lys Pro Asn Gln Asn Lys Ala Pro Met Lys Glu Thr Lys 
    530                 535                 540                 

Arg Gln Leu Pro Ser Thr Gly Glu Thr Ala Asn Pro Phe Phe Thr Ala 
545                 550                 555                 560 

Ala Ala Leu Thr Val Met Ala Thr Ala Gly Val Ala Ala Val Val Lys 
                565                 570                 575     

Arg Lys Glu Glu Asn 
            580     

<210>   53
<211>   384
<212>   PRT
<213>   Streptococcus pyogenes

<220>
<221>   DOMAIN
<222>   (1)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<220>
<221>   DOMAIN
<222>   (351) ... (384)
<223>   Portion that was not expressed on the basis that it appeared to be a leader sequence or a transmembrane domain

<400>   53
Met Ala Arg Lys Asp Thr Asn Lys Gln Tyr Ser Leu Arg Lys Leu Lys 
1               5                   10                  15      

Thr Gly Thr Ala Ser Val Ala Val Ala Val Ala Val Leu Gly Ala Gly 
            20                  25                  30          

Phe Ala Asn Gln Thr Glu Val Lys Ala Glu Gly Val Lys Lys Ala Glu 
        35                  40                  45              

Glu Ala Lys Leu Ser Val Pro Lys Thr Glu Tyr Asp Lys Leu Tyr Asp 
    50                  55                  60                  

Asp Tyr Asp Lys Leu Gln Glu Lys Ser Ala Glu Tyr Leu Glu Arg Ile 
65                  70                  75                  80  

Gly Glu Leu Glu Glu Arg Gln Lys Asn Leu Glu Lys Leu Glu Arg Gln 
                85                  90                  95      

Ser Gln Val Ala Ala Asp Lys His Tyr Gln Glu Gln Val Lys Lys His 
            100                 105                 110         

Gln Glu Tyr Lys Gln Glu Gln Glu Glu Arg Gln Lys Asn Leu Glu Glu 
        115                 120                 125             

Leu Glu Arg Gln Asn Lys Arg Glu Ile Asp Lys Arg Tyr Lys Glu Gln 
    130                 135                 140                 

Leu His Lys Gln Gln Gln Leu Glu Thr Glu Lys Gln Ile Ser Glu Ala 
145                 150                 155                 160 

Ser Arg Lys Ser Leu Ser Arg Asp Leu Glu Ala Ser Arg Glu Ala Lys 
                165                 170                 175     

Lys Lys Val Glu Ala Asp Leu Ala Ala Leu Glu Ala Glu His Gln Lys 
            180                 185                 190         

Leu Lys Glu Glu Lys Gln Ile Ser Asp Ala Ser Arg Gln Ser Leu Ser 
        195                 200                 205             

Arg Asp Leu Glu Ala Ser Arg Glu Ala Lys Lys Lys Val Glu Ala Asp 
    210                 215                 220                 

Leu Ala Ala Leu Thr Ala Glu His Gln Lys Leu Lys Glu Glu Lys Gln 
225                 230                 235                 240 

Ile Ser Asp Ala Ser Arg Gln Gly Leu Ser Arg Asp Leu Glu Ala Ser 
                245                 250                 255     

Arg Glu Ala Lys Lys Lys Val Glu Ala Asp Leu Ala Glu Ala Asn Ser 
            260                 265                 270         

Lys Leu Gln Ala Leu Glu Lys Leu Asn Lys Glu Leu Glu Glu Gly Lys 
        275                 280                 285             

Lys Leu Ser Glu Lys Glu Lys Ala Glu Leu Gln Ala Lys Leu Glu Ala 
    290                 295                 300                 

Glu Ala Lys Ala Leu Lys Glu Gln Leu Ala Lys Gln Ala Glu Glu Leu 
305                 310                 315                 320 

Ala Lys Leu Lys Gly Asn Gln Thr Pro Asn Ala Lys Val Ala Pro Gln 
                325                 330                 335     

Ala Asn Arg Ser Arg Ser Ala Met Thr Gln Gln Lys Arg Thr Leu Pro 
            340                 345                 350         

Ser Thr Gly Glu Thr Ala Asn Pro Phe Phe Thr Ala Ala Ala Ala Thr 
        355                 360                 365             

Val Met Val Ser Ala Gly Met Leu Ala Leu Lys Arg Lys Glu Glu Asn 
    370                 375                 380                 


