                         SEQUENCE LISTING

<110>  LFB Biotechnologies
 
<120>  Anticorps monoclonal anti-Rhsus D

<130>  B849

<160>  11    

<170>  PatentIn version 3.3

<210>  1
<211>  1425
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (58)..(1425)

<400>  1
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgt        57

cag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg agg      105
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt aca gcc tct gga ttc acc ttc aaa aac tat      153
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Lys Asn Tyr         
            20                  25                  30                  

gct atg cat tgg gtc cgc cag gct cca gcc aag ggg ctg gag tgg gtg      201
Ala Met His Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

gca act ata tca tat gat gga agg aat ata caa tat gca gac tcc gtg      249
Ala Thr Ile Ser Tyr Asp Gly Arg Asn Ile Gln Tyr Ala Asp Ser Val         
    50                  55                  60                          

aag ggc cga ttc acc ttc tcc aga gac aat tct cag gac acc ctg tat      297
Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ser Gln Asp Thr Leu Tyr         
65                  70                  75                  80          

ctg caa ctg aac agc ctc aga ccg gag gac acg gct gtg tat tac tgt      345
Leu Gln Leu Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga ccc gta aga agc cga tgg ctg caa tta ggt ctt gaa gat gct      393
Ala Arg Pro Val Arg Ser Arg Trp Leu Gln Leu Gly Leu Glu Asp Ala         
            100                 105                 110                 

ttt cat atc tgg ggc cag ggg aca atg gtc acc gtc tct tca gcc tcc      441
Phe His Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser         
        115                 120                 125                     

acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc      489
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr         
    130                 135                 140                         

tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc      537
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro         
145                 150                 155                 160         

gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg      585
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val         
                165                 170                 175             

cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc      633
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser         
            180                 185                 190                 

agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc      681
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile         
        195                 200                 205                     

tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt      729
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val         
    210                 215                 220                         

gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca      777
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala         
225                 230                 235                 240         

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc      825
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro         
                245                 250                 255             

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg      873
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val         
            260                 265                 270                 

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg      921
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val         
        275                 280                 285                     

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag      969
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln         
    290                 295                 300                         

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag     1017
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln         
305                 310                 315                 320         

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc     1065
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala         
                325                 330                 335             

ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc     1113
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro         
            340                 345                 350                 

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc     1161
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr         
        355                 360                 365                     

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc     1209
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser         
    370                 375                 380                         

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac     1257
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr         
385                 390                 395                 400         

aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac     1305
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr         
                405                 410                 415             

agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc     1353
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe         
            420                 425                 430                 

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag     1401
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys         
        435                 440                 445                     

agc ctc tcc ctg tct ccg ggt aaa                                     1425
Ser Leu Ser Leu Ser Pro Gly Lys                                         
    450                 455                                             


<210>  2
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Lys Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Tyr Asp Gly Arg Asn Ile Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ser Gln Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Val Arg Ser Arg Trp Leu Gln Leu Gly Leu Glu Asp Ala 
            100                 105                 110         


Phe His Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  3
<211>  708
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (67)..(708)

<400>  3
atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggtgcc     60

agatgt gcc atc cgg atg acc cag tct cca tcc tca ttc tct gca tct       108
       Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser          
       1               5                   10                           

aca gga gac aga gtc acc atc act tgt cgg gcg agc cag gat att cgg      156
Thr Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg         
15                  20                  25                  30          

aac tat gta gcc tgg tat cag caa aaa tca ggg aaa gcc cct aaa ttc      204
Asn Tyr Val Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Phe         
                35                  40                  45              

ctg atc tat gct gct tcc act ttg caa agt ggg gtc cca tca agg ttc      252
Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe         
            50                  55                  60                  

agc ggc agt gga tct ggg aca gat ttc act ctc acc atc aac tcc ctg      300
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu         
        65                  70                  75                      

cag tct gaa gat ttt gca act tat tac tgt caa caa tat tac aat tct      348
Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Ser         
    80                  85                  90                          

cct ccg acc ttc ggc caa ggg acc agg gtg gaa atc acg cga act gtg      396
Pro Pro Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Thr Arg Thr Val         
95                  100                 105                 110         

gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa      444
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys         
                115                 120                 125             

tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga      492
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg         
            130                 135                 140                 

gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac      540
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn         
        145                 150                 155                     

tcc cag gag agt gtc aca gag cag gac agc aag gac agc acc tac agc      588
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser         
    160                 165                 170                         

ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa      636
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys         
175                 180                 185                 190         

gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca      684
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr         
                195                 200                 205             

aag agc ttc aac agg gga gag tgt                                      708
Lys Ser Phe Asn Arg Gly Glu Cys                                         
            210                                                         


<210>  4
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Thr Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  5
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  5

Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Lys Cys Thr Phe Ser Arg 
1               5                   10                  15      


<210>  6
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  6

Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Lys 
1               5                   10      


<210>  7
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Thr Phe Ser Arg 
1               5   


<210>  8
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Asn Ser Gln Asp Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Pro 
1               5                   10                  15      


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Cys Thr Phe Ser Arg 
            20                  25                  30      


<210>  9
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Asn Ser Gln Asp Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Pro 
1               5                   10                  15      


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25      


<210>  10
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  amorce (primer)

<400>  10
ctatatcata tgatggaagg aatatacaat atgcagactc cgtgaagggc cgattcacct     60

tctc                                                                  64


<210>  11
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  amorce (primer)

<400>  11
ggaagtagtc cttgaccagg cag                                             23


