                         SEQUENCE LISTING

<110>  Codexis, Inc.
       Baidyaroy, Dipnath
       Clark, Louis
       Newman, Lisa
       Ching, Charlene
 
<120>  Beta-Glucosidase Variant Enzymes And Related Polynucleotides

<130>  CX3-003WO1

<150>  61/155,754
<151>  2009-02-26

<160>  124   

<170>  PatentIn version 3.5

<210>  1
<211>  1356
<212>  DNA
<213>  T. brockii beta-glucosidase


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  1
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  2
<211>  450
<212>  PRT
<213>  T. brockii beta-glucosidase

<400>  2

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  3
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  3
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  4
<211>  450
<212>  PRT
<213>  Variant

<400>  4

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  5
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  5
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg aca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gtt cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  6
<211>  450
<212>  PRT
<213>  Variant

<400>  6

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  7
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  7
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa acc tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gtc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Val Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca aac gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Asn Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cga att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa atc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Ile Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  8
<211>  450
<212>  PRT
<213>  Variant

<400>  8

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Val Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Asn Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Ile Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  9
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  9
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt gac tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act agc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  10
<211>  450
<212>  PRT
<213>  Variant

<400>  10

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  11
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  11
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tcg agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gag gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac cat aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His His Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctc gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  12
<211>  450
<212>  PRT
<213>  Variant

<400>  12

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His His Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  13
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  13
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gtc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Val Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca tgg ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Trp Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  14
<211>  450
<212>  PRT
<213>  Variant

<400>  14

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Val Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Trp Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  15
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  15
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca ttg ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Leu Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  16
<211>  450
<212>  PRT
<213>  Variant

<400>  16

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Leu Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  17
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  17
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca gtg ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Val Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  18
<211>  450
<212>  PRT
<213>  Variant

<400>  18

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Val Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  19
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  19
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca ttt ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Phe Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  20
<211>  450
<212>  PRT
<213>  Variant

<400>  20

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Phe Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  21
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  21
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga gtc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Val Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca gtt ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Val Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  22
<211>  450
<212>  PRT
<213>  Variant

<400>  22

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Val Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Val Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  23
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  23
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gaa cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca gtt ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Val Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  24
<211>  450
<212>  PRT
<213>  Variant

<400>  24

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Val Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  25
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  25
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gtg        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Val           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc act cca gcg tat ccc acc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Thr Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  26
<211>  450
<212>  PRT
<213>  Variant

<400>  26

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Val 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Thr Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  27
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  27
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tat agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg ttg gaa att tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Leu Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctc       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  28
<211>  450
<212>  PRT
<213>  Variant

<400>  28

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Leu Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  29
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  29
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg cac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met His           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  30
<211>  451
<212>  PRT
<213>  Variant

<400>  30

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met His 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  31
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  31
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat att ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aga ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Arg Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  32
<211>  451
<212>  PRT
<213>  Variant

<400>  32

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Arg Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  33
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  33
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gag gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aat ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Asn Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  34
<211>  451
<212>  PRT
<213>  Variant

<400>  34

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Asn Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  35
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  35
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa gcg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Ala Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt ata gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  36
<211>  450
<212>  PRT
<213>  Variant

<400>  36

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Ala Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  37
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  37
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt gac tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg tat ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  38
<211>  451
<212>  PRT
<213>  Variant

<400>  38

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  39
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  39
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act cac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr His Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  40
<211>  450
<212>  PRT
<213>  Variant

<400>  40

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr His Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  41
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  41
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

atc gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc gaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Glu Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  42
<211>  451
<212>  PRT
<213>  Variant

<400>  42

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Glu Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  43
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  43
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  44
<211>  450
<212>  PRT
<213>  Variant

<400>  44

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  45
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  45
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg ggt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Gly Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggc ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  46
<211>  451
<212>  PRT
<213>  Variant

<400>  46

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Gly Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  47
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  47
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat att ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gtg gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  48
<211>  451
<212>  PRT
<213>  Variant

<400>  48

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  49
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  49
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc gaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Glu Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  50
<211>  451
<212>  PRT
<213>  Variant

<400>  50

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Glu Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  51
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  51
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg aca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc ggc ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Gly Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg ttg gaa gtc tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Leu Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aat cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Asn Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  52
<211>  451
<212>  PRT
<213>  Variant

<400>  52

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Gly Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Leu Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Asn Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  53
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  53
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  54
<211>  450
<212>  PRT
<213>  Variant

<400>  54

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  55
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  55
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gca tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat ccg aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat aaa ggc ggt gac tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Lys Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa ggc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Gly Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  56
<211>  451
<212>  PRT
<213>  Variant

<400>  56

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Lys Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Gly Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  57
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  57
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  58
<211>  450
<212>  PRT
<213>  Variant

<400>  58

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  59
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  59
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  60
<211>  451
<212>  PRT
<213>  Variant

<400>  60

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  61
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  61
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc ata cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg ttg gaa gtc tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Leu Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gac agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  62
<211>  451
<212>  PRT
<213>  Variant

<400>  62

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Leu Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  63
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  63
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tat gat att ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gaa gag ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Glu Glu Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  64
<211>  450
<212>  PRT
<213>  Variant

<400>  64

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Glu Glu Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  65
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  65
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  66
<211>  450
<212>  PRT
<213>  Variant

<400>  66

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  67
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  67
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat att ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg tat ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg gtc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Val           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  68
<211>  451
<212>  PRT
<213>  Variant

<400>  68

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Val 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  69
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  69
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt ggg gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Gly Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att acc gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  70
<211>  451
<212>  PRT
<213>  Variant

<400>  70

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Gly Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  71
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  71
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

gtt gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Val Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gct acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gcc aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct ttg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Leu Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  72
<211>  451
<212>  PRT
<213>  Variant

<400>  72

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Val Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Leu Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  73
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  73
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tat gat att ggc ggt gac tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gac atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  74
<211>  451
<212>  PRT
<213>  Variant

<400>  74

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  75
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  75
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  76
<211>  451
<212>  PRT
<213>  Variant

<400>  76

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  77
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  77
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tat gat att ggc ggt gac tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  78
<211>  451
<212>  PRT
<213>  Variant

<400>  78

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  79
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  79
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  80
<211>  450
<212>  PRT
<213>  Variant

<400>  80

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  81
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  81
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tat gat att ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg tat ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtc tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  82
<211>  451
<212>  PRT
<213>  Variant

<400>  82

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  83
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  83
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat att ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  84
<211>  450
<212>  PRT
<213>  Variant

<400>  84

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  85
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  85
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat att ggc ggt gac tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc gcc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Ala Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  86
<211>  450
<212>  PRT
<213>  Variant

<400>  86

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Ala Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  87
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  87
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cga att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cac gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys His Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tat gat att ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cat cat att ttg ttg tcg tat ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa atc tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  88
<211>  451
<212>  PRT
<213>  Variant

<400>  88

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys His Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  89
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  89
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  90
<211>  451
<212>  PRT
<213>  Variant

<400>  90

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  91
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  91
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat att ggc ggt gac tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  92
<211>  451
<212>  PRT
<213>  Variant

<400>  92

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  93
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  93
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat att ggc ggt gac tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

tcc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Ser Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa atc tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  94
<211>  450
<212>  PRT
<213>  Variant

<400>  94

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Ser Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  95
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  95
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att gga gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa atc tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  96
<211>  450
<212>  PRT
<213>  Variant

<400>  96

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


<210>  97
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  97
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat att ggc ggt gac tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtt        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  98
<211>  451
<212>  PRT
<213>  Variant

<400>  98

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  99
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  99
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag gag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Glu Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat att ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg cat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala His Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  100
<211>  451
<212>  PRT
<213>  Variant

<400>  100

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Glu Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala His Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  101
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  101
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  102
<211>  451
<212>  PRT
<213>  Variant

<400>  102

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  103
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  103
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  104
<211>  451
<212>  PRT
<213>  Variant

<400>  104

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  105
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  105
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa aag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat att ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg tat ggt gaa ggg gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Gly Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa atc tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  106
<211>  451
<212>  PRT
<213>  Variant

<400>  106

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Lys 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Gly Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  107
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  107
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat att ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cat cat att ttg ttg tcg tat ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac cca atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aag gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgc gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  108
<211>  451
<212>  PRT
<213>  Variant

<400>  108

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  109
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  109
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  110
<211>  451
<212>  PRT
<213>  Variant

<400>  110

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  111
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  111
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag cca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Pro Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  112
<211>  451
<212>  PRT
<213>  Variant

<400>  112

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Pro Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  113
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  113
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tat gat aaa ggc ggt gac tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg tat ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  114
<211>  451
<212>  PRT
<213>  Variant

<400>  114

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser Tyr Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  115
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  115
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg ttg gaa atc tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Leu Glu Ile Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  116
<211>  451
<212>  PRT
<213>  Variant

<400>  116

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Leu Glu Ile Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  117
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  117
atg att aaa tta gcc aag ttt ccg cgt gat tta gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Leu Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

ttt gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc gta cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa ggc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Gly Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag atg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala           
225                 230                 235                 240           

acg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Thr Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtc tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gcg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Ala Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cct tga                                                       1356
Glu Asp Pro                                                               
    450                                                                   


<210>  118
<211>  451
<212>  PRT
<213>  Variant

<400>  118

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Leu Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Phe Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Val Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Gly Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Met Ala 
225                 230                 235                 240 


Thr Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Ala Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Pro 
    450     


<210>  119
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  119
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt gac tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc atc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val           
    290                 295                 300                           

aaa tac gct gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  120
<211>  451
<212>  PRT
<213>  Variant

<400>  120

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Asp Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val 
    290                 295                 300                 


Lys Tyr Ala Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  121
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  121
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt gac gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aaa        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att gct tgg acg cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tat gat aaa ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gcc att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg gaa acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtc gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gat gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca cac ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act tcg cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac cag tga                                                       1356
Glu Asp Gln                                                               
    450                                                                   


<210>  122
<211>  451
<212>  PRT
<213>  Variant

<400>  122

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asp Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Thr Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Lys Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Ser Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp Gln 
    450     


<210>  123
<211>  1356
<212>  DNA
<213>  Variant


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  123
atg att aaa tta gcc aag ttt ccg cgt gat ttt gtg tgg gga acg gcg         48
Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala           
1               5                   10                  15                

aca tcc agt tat caa atc gaa ggg gct gtt aat gaa gat ggt cgt acc         96
Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr           
            20                  25                  30                    

ccg agt atc tgg gat acc ttc tct aaa acg gag ggg aaa act tac aac        144
Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Asn           
        35                  40                  45                        

ggt cat aca ggt gat gtc gca tgt gac cat tat cat cgc tac aaa gag        192
Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu           
    50                  55                  60                            

gat gtc gag atc tta aaa gaa att gga gta aag gcc tac cgc ttc tcg        240
Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser           
65                  70                  75                  80            

att ccg tgg cca cgt att ttc cca gaa gaa ggc aaa tac aat cca aaa        288
Ile Pro Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys           
                85                  90                  95                

ggc atg gat ttt tac aag aag ttg atc gat gaa ctc cag aag cgc gat        336
Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp           
            100                 105                 110                   

att gtc ccc gcg gcg acg att tat cac tgg gat tta ccg cag tgg gcg        384
Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala           
        115                 120                 125                       

tac gat ata ggc ggt ggc tgg tta aat cgt gaa agc atc aaa tgg tat        432
Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr           
    130                 135                 140                           

gta gaa tat gca acc aaa ctt ttt gag gaa ttg ggt gac gtg att cct        480
Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Val Ile Pro           
145                 150                 155                 160           

ctc tgg atc aca cat aat gaa ccg tgg tgt tca agt att ttg agc tat        528
Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr           
                165                 170                 175               

ggt att ggt gag cat gcg cct ggc cat aaa aac tat cgc gaa gca ctc        576
Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu           
            180                 185                 190                   

att gct gca cac cat att ttg ttg tcg cac ggt gaa gcc gtg aaa gca        624
Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala           
        195                 200                 205                       

ttc cgg gag atg aat atc aaa ggg tcc aag att gga atc acc ctc aat        672
Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn           
    210                 215                 220                           

ctc acc cca gcg tat ccc gcc agc gag aaa gaa gaa gat aag ttg gcg        720
Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala           
225                 230                 235                 240           

gcg cag tac gcc gac ggc ttt gct aac cgt tgg ttc ctc gac ccg atc        768
Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile           
                245                 250                 255               

ttc aaa gga aac tac ccg gaa gat atg atg gag tta tac agc aag atc        816
Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile           
            260                 265                 270                   

atc ggc gag ttt gat ttt atc aaa gaa ggc gac ttg ggt acg atc tct        864
Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Gly Thr Ile Ser           
        275                 280                 285                       

gtc cca atc gac ttt tta ggt gtt aac tat tat acg cgc tcc gtt gtc        912
Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val           
    290                 295                 300                           

aaa tac gac gaa gac tct atg ctt aaa gcc gaa aac gta cct ggt ccg        960
Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro           
305                 310                 315                 320           

ggc aaa cgc acc gag atg ggg tgg gaa gtt tcg ccg gag tca tta tat       1008
Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr           
                325                 330                 335               

gac ctt ctt aag cgg ctc gac cgt gag tat acc aaa tta cct atg tac       1056
Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr           
            340                 345                 350                   

att act gaa aac ggc gct gca ttc aaa gac gaa gtt act gaa gat ggg       1104
Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly           
        355                 360                 365                       

cgc gtt cac gat gat gag cgt att gaa tac atc aaa gag cac ctt aag       1152
Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys           
    370                 375                 380                           

gcg gcc gct aaa ttc att gga gaa ggt ggc aac ctt aaa ggt tac ttc       1200
Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe           
385                 390                 395                 400           

gtg tgg tca ttg atg gat aat ttt gaa tgg gca gtc ggg tat tcc aaa       1248
Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Val Gly Tyr Ser Lys           
                405                 410                 415               

cgt ttt ggc att gtt tat gta gat tat act acc cag aaa cgc atc ctt       1296
Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu           
            420                 425                 430                   

aaa gat agt gcg ttg tgg tac aaa gaa gtg att ctt gat gac ggc att       1344
Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile           
        435                 440                 445                       

gaa gac taa tga                                                       1356
Glu Asp                                                                   
    450                                                                   


<210>  124
<211>  450
<212>  PRT
<213>  Variant

<400>  124

Met Ile Lys Leu Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ser Ser Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr 
            20                  25                  30          


Pro Ser Ile Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Asn 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu 
    50                  55                  60                  


Asp Val Glu Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Pro Trp Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys 
                85                  90                  95      


Gly Met Asp Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp 
            100                 105                 110         


Ile Val Pro Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala 
        115                 120                 125             


Tyr Asp Ile Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr 
    130                 135                 140                 


Val Glu Tyr Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Val Ile Pro 
145                 150                 155                 160 


Leu Trp Ile Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr 
                165                 170                 175     


Gly Ile Gly Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu 
            180                 185                 190         


Ile Ala Ala His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala 
        195                 200                 205             


Phe Arg Glu Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn 
    210                 215                 220                 


Leu Thr Pro Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala 
225                 230                 235                 240 


Ala Gln Tyr Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile 
                245                 250                 255     


Phe Lys Gly Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile 
            260                 265                 270         


Ile Gly Glu Phe Asp Phe Ile Lys Glu Gly Asp Leu Gly Thr Ile Ser 
        275                 280                 285             


Val Pro Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Val Val 
    290                 295                 300                 


Lys Tyr Asp Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro 
305                 310                 315                 320 


Gly Lys Arg Thr Glu Met Gly Trp Glu Val Ser Pro Glu Ser Leu Tyr 
                325                 330                 335     


Asp Leu Leu Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr 
            340                 345                 350         


Ile Thr Glu Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly 
        355                 360                 365             


Arg Val His Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys 
    370                 375                 380                 


Ala Ala Ala Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe 
385                 390                 395                 400 


Val Trp Ser Leu Met Asp Asn Phe Glu Trp Ala Val Gly Tyr Ser Lys 
                405                 410                 415     


Arg Phe Gly Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu 
            420                 425                 430         


Lys Asp Ser Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile 
        435                 440                 445             


Glu Asp 
    450 


