                                SEQUENCE LISTING

<110> Bevins, Charles I.
      Lau, Tsang
      Cherr, Gary N.
      Yudin, Ashley I.
      Tollner, Theodore L.
      Overstreet, James W.
      Venners, Scott
      Xu, Xiping
      The Regents of the University of California
      

<120> Infertility Associated DEFB-126 Deletion
  Polymorphism

<130> 02307O-195310PC

<140> WO PCT/US10/Not yet assigned 
<141> Not yet assigned  

<150> US 61/155,807       
<151> 2009-02-26  

<160> 49

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic wild-type human DEFB-126 nucleotide
      sequence spanning region encompassing DEFB-126
      deletion polymorphism, DEFB-126 subsequence

<400> 1
tcctaccccc gtttc                                                  15

<210> 2
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic wild-type human DEFB-126 nucleotide,
      DEFB-126 subsequence sequence spanning region
      encompassing DEFB-126 deletion polymorphism

<400> 2
atggctccta cccccgtttc tccca                                       25

<210> 3
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic wild-type human DEFB-126 polypeptide
      C-terminal sequence

<400> 3
Pro Val Ser Pro Thr Gly
 1               5      


<210> 4
<211> 413
<212> DNA
<213> Homo sapiens

<220> 
<223> human wild-type beta defensin 126 (DEFB-126,
      DEFB126, DEFB-26, DEFB26, hBD-26) preprotein,
      epididymal secretory protein ESP13.2, bA530N10.1,
      C20orf8 cDNA

<400> 4
agaacccact gcctcctgat gaagtcccta ctgttcaccc ttgcagtttt tatgctcctg 60
gcccaattgg tctcaggtaa ttggtatgtg aaaaagtgtc taaacgacgt tggaatttgc 120
aagaagaagt gcaaacctga agagatgcat gtaaagaatg gttgggcaat gtgcggcaaa 180
caaagggact gctgtgttcc agctgacaga cgtgctaatt atcctgtttt ctgtgtccag 240
acaaagacta caagaatttc aacagtaaca gcaacaacag caacaacaac tttgatgatg 300
actactgctt cgatgtcttc gatggctcct acccccgttt ctcccactgg ttgaacattc 360
cagcctctgt ctcctgctct aggatccccg actcattaaa gcaaagaggc tta        413

<210> 5
<211> 468
<212> DNA
<213> Homo sapiens

<220> 
<223> human wild-type beta defensin 126 (DEFB-126)

<220> 
<221> modified_base  
<222> (27)...(27)
<223> n = g, a, c or t

<400> 5
actcactata gggcggccgc gaattcngac cagagaaccc actgcctcct gatgaagtcc 60
ctactgttca cccttgcagt ttttatgctc ctggcccaat tggtctcagg taattggtat 120
gtgaaaaagt gtctaaacga cgttggaatt tgcaagaaga agtgcaaacc tgaagagatg 180
catgtaaaga atggttgggc aatgtgcggc aaacaaaggg actgctgtgt tccagctgac 240
agacgtgcta attatcctgt tttctgtgtc cagacaaaga ctacaagaat ttcaacagta 300
acagcaacaa cagcaacaac aactttgatg atgactactg cttcgatgtc ttcgatggct 360
cctacccccg tttctcccac tggttgaaca ttccagcctc tgtctcctgc tctaggatcc 420
ccgactcatt aaagcaaaga ggcttaaaaa aaaaaaaaaa aaaaaaaa              468

<210> 6
<211> 111
<212> PRT
<213> Homo sapiens

<220> 
<223> human wild-type beta defensin 126 (DEFB-126,
      DEFB126, DEFB-26, DEFB26, hBD-26) preprotein,
      epididymal secretory protein ESP13.2, bA530N10.1,
      C20orf8

<400> 6
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly
            20                  25                  30          
Ile Cys Lys Lys Lys Cys Lys Pro Glu Glu Met His Val Lys Asn Gly
        35                  40                  45              
Trp Ala Met Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Arg
    50                  55                  60                  
Arg Ala Asn Tyr Pro Val Phe Cys Val Gln Thr Lys Thr Thr Arg Ile
65                  70                  75                  80  
Ser Thr Val Thr Ala Thr Thr Ala Thr Thr Thr Leu Met Met Thr Thr
                85                  90                  95      
Ala Ser Met Ser Ser Met Ala Pro Thr Pro Val Ser Pro Thr Gly
            100                 105                 110     


<210> 7
<211> 112
<212> PRT
<213> Hylobates lar

<220> 
<223> common gibbon wild-type beta defensin 126
      (DEFB-126, DEFB126, DEFB-26, DEFB26)

<400> 7
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly
            20                  25                  30          
Ile Cys Lys Lys Lys Cys Lys Pro Glu Glu Leu His Val Lys Asn Gly
        35                  40                  45              
Arg Ala Met Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Lys
    50                  55                  60                  
Arg Ala Asn Tyr Pro Ala Phe Cys Val Gln Thr Lys Thr Thr Arg Thr
65                  70                  75                  80  
Ser Thr Val Thr Ala Thr Ala Ala Thr Thr Thr Thr Leu Val Met Thr
                85                  90                  95      
Thr Ala Ser Met Ser Ser Met Ala Pro Thr Pro Val Ser Pro Thr Ser
            100                 105                 110         


<210> 8
<211> 111
<212> PRT
<213> Gorilla gorilla

<220> 
<223> Western lowland gorilla wild-type beta defensin
      126 (DEFB-126, DEFB126, DEFB-26, DEFB26)

<400> 8
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly
            20                  25                  30          
Ile Cys Lys Lys Lys Cys Lys Pro Glu Glu Met His Val Lys Asn Gly
        35                  40                  45              
Trp Ala Met Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Arg
    50                  55                  60                  
Arg Ala Asn Tyr Pro Ala Phe Cys Val Gln Thr Lys Thr Thr Arg Thr
65                  70                  75                  80  
Ser Thr Val Thr Ala Thr Thr Ala Thr Thr Thr Leu Met Met Thr Thr
                85                  90                  95      
Ala Ser Met Ser Leu Met Ala Pro Thr Pro Val Ser Pro Thr Gly
            100                 105                 110     


<210> 9
<211> 108
<212> PRT
<213> Pan troglodytes

<220> 
<223> chimpanzee wild-type beta defensin 126 (DEFB-126,
      DEFB126, DEFB-26, DEFB26)

<400> 9
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly
            20                  25                  30          
Ile Cys Lys Lys Lys Cys Lys Pro Gly Glu Met His Ile Lys Asn Gly
        35                  40                  45              
Trp Ala Thr Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Arg
    50                  55                  60                  
Arg Ala Asn Tyr Pro Ala Phe Cys Val Gln Thr Lys Thr Thr Arg Thr
65                  70                  75                  80  
Ser Thr Val Thr Ala Arg Thr Thr Leu Met Val Thr Thr Ala Ser Met
                85                  90                  95      
Ser Ser Met Ala Pro Thr Pro Val Ser Pro Thr Gly
            100                 105             


<210> 10
<211> 135
<212> PRT
<213> Macaca fascicularis

<220> 
<223> crab-eating macaque wild-type beta defensin 126
      (DEFB-126, DEFB126, DEFB-26, DEFB26)

<400> 10
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Asn Leu Tyr Val Lys Arg Cys Leu Asn Asp Ile Gly
            20                  25                  30          
Ile Cys Lys Lys Thr Cys Lys Pro Glu Glu Val Arg Ser Glu His Gly
        35                  40                  45              
Trp Val Met Cys Gly Lys Arg Lys Ala Cys Cys Val Pro Ala Asp Lys
    50                  55                  60                  
Arg Ser Ala Tyr Pro Ser Phe Cys Val His Ser Lys Thr Thr Lys Thr
65                  70                  75                  80  
Ser Thr Val Thr Ala Arg Ala Thr Ala Thr Thr Ala Thr Thr Ala Thr
                85                  90                  95      
Ala Ala Thr Pro Leu Met Ile Ser Asn Gly Leu Ile Ser Leu Met Ser
            100                 105                 110         
Tyr Asp Gly Arg Tyr Pro Cys Phe Ser His Tyr Leu Asn Ile Pro Ala
        115                 120                 125             
Ser Val Ser Cys Ser Arg Ser
    130                 135 


<210> 11
<211> 118
<212> PRT
<213> Pongo pygmaeus

<220> 
<223> Bornean orangutan wild-type beta defensin 126
      (DEFB-126, DEFB126, DEFB-26, DEFB26)

<400> 11
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Ser Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly
            20                  25                  30          
Ile Cys Lys Lys Lys Cys Lys Pro Glu Glu Leu His Val Lys Asn Gly
        35                  40                  45              
Trp Ala Met Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Lys
    50                  55                  60                  
Arg Ala Asn Tyr Pro Ala Phe Cys Val Gln Thr Lys Thr Thr Arg Thr
65                  70                  75                  80  
Ser Thr Val Thr Ala Thr Thr Ala Thr Arg Ala Thr Thr Ala Thr Thr
                85                  90                  95      
Thr Thr Leu Met Met Thr Thr Ala Ser Met Ser Ser Met Thr Pro Thr
            100                 105                 110         
Pro Val Ser Pro Thr Gly
        115             


<210> 12
<211> 129
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic wild-type DEFB-126 protein primate
      consensus sequence

<220> 
<221> VARIANT        
<222> (63)...(63)
<223> Xaa = Lys or Arg

<400> 12
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly
            20                  25                  30          
Ile Cys Lys Lys Lys Cys Lys Pro Glu Glu His Val Lys Asn Gly Trp
        35                  40                  45              
Ala Met Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Xaa Arg
    50                  55                  60                  
Ala Asn Tyr Pro Ala Phe Cys Val Gln Thr Lys Thr Thr Arg Thr Ser
65                  70                  75                  80  
Thr Val Thr Ala Thr Thr Ala Thr Thr Thr Ala Thr Thr Thr Leu Met
                85                  90                  95      
Met Thr Thr Ala Ser Met Ser Ser Met Ala Tyr Asp Gly Arg Tyr Pro
            100                 105                 110         
Cys Phe Ser His Tyr Leu Asn Ile Pro Thr Pro Val Ser Pro Thr Gly
        115                 120                 125             
Ser
    

<210> 13
<211> 461
<212> DNA
<213> Homo sapiens

<220> 
<223> human DEFB-126 with deletion polymorphism frame
      shift

<400> 13
atagagactt ctggactcta tagaacccac tgcctcctga tgaagtccct actgttcacc 60
cttgcagttt ttatgctcct ggcccaattg gtctcaggta attggtatgt gaaaaagtgt 120
ctaaacgacg ttggaatttg caagaagaag tgcaaacctg aagagatgca tgtaaagaat 180
ggttgggcaa tgtgcggcaa acaaagggac tgctgtgttc cagctgacag acgtgctaat 240
tatcctgttt tctgtgtcca gacaaagact acaagaattt caacagtaac agcaacaaca 300
gcaacaacaa ctttgatgat gactactgct tcgatgtctt cgatggctcc tacccgtttc 360
tcccactggt tgaacattcc agcctctgtc tcctgctcta ggatccccga ctcattaaag 420
caaagaggct taaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                     461

<210> 14
<211> 466
<212> DNA
<213> Homo sapiens

<220> 
<223> human DEFB-126 with deletion polymorphism frame
      shift

<220> 
<221> modified_base  
<222> (27)...(27)
<223> n = g, a, c or t

<400> 14
actcactata gggcggccgc gaattcngac cagagaaccc actgcctcct gatgaagtcc 60
ctactgttca cccttgcagt ttttatgctc ctggcccaat tggtctcagg taattggtat 120
gtgaaaaagt gtctaaacga cgttggaatt tgcaagaaga agtgcaaacc tgaagagatg 180
catgtaaaga atggttgggc aatgtgcggc aaacaaaggg actgctgtgt tccagctgac 240
agacgtgcta attatcctgt tttctgtgtc cagacaaaga ctacaagaat ttcaacagta 300
acagcaacaa cagcaacaac aactttgatg atgactactg cttcgatgtc ttcgatggct 360
cctacccgtt tctcccactg gttgaacatt ccagcctctg tctcctgctc taggatcccc 420
gactcattaa agcaaagagg cttaaaaaaa aaaaaaaaaa aaaaaa                466

<210> 15
<211> 431
<212> DNA
<213> Homo sapiens

<220> 
<223> human DEFB-126 with deletion polymorphism frame
      shift (reverse complement), EST00015

<400> 15
agacagaggc tggaatgtca accagtggga gaaacgggta ggagccatcg aagacatcga 60
agcagtagtc atcatcaaag ttgttgttgc tgttgttgct gttactgttg aaattcttgt 120
agtctttgtc tggacacaga aaacaggata attagcacgt ctgtcagctg gaacacagca 180
gtccctttgt ttgccgcaca ttgcccaacc attctttaca tgcatctctt caggtttgca 240
cttcttcttg caaattccaa cgtcgtttag acactttttc acataccaat tacctgagac 300
caattgggcc aggagcataa aaactgcaag ggtgaacagt agggacttca tcaggaggca 360
gtgggttcta tagagtccag aagtctctat tcagtatgac tctgaacaca gatctttatt 420
gtccttcccc c                                                      431

<210> 16
<211> 181
<212> PRT
<213> Homo sapiens

<220> 
<223> human DEFB-126 with deletion polymorphism frame
      shift, DEFB-126 variant polypeptide with extended
      C-terminal region

<220> 
<221> VARIANT        
<222> (133)...(181)
<223> Lys may be present or absent

<400> 16
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly
            20                  25                  30          
Ile Cys Lys Lys Lys Cys Lys Pro Glu Glu Met His Val Lys Asn Gly
        35                  40                  45              
Trp Ala Met Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Arg
    50                  55                  60                  
Arg Ala Asn Tyr Pro Val Phe Cys Val Gln Thr Lys Thr Thr Arg Ile
65                  70                  75                  80  
Ser Thr Val Thr Ala Thr Thr Ala Thr Thr Thr Leu Met Met Thr Thr
                85                  90                  95      
Ala Ser Met Ser Ser Met Ala Pro Thr Arg Phe Ser His Trp Leu Asn
            100                 105                 110         
Ile Pro Ala Ser Val Ser Cys Ser Arg Ile Pro Asp Ser Leu Lys Gln
        115                 120                 125             
Arg Gly Leu Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
    130                 135                 140                 
Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
145                 150                 155                 160 
Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
                165                 170                 175     
Lys Lys Lys Lys Lys
            180     


<210> 17
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic human DEFB-126 with deletion
      polymorphism frame shift C-terminal sequence,
      DEFB-126 variant polypeptide C-terminal sequence

<220> 
<221> VARIANT        
<222> (74)...(122)
<223> Lys may be present or absent

<400> 17
Val Pro Ala Asp Arg Arg Ala Asn Tyr Pro Val Phe Cys Val Gln Thr
 1               5                  10                  15      
Lys Thr Thr Arg Ile Ser Thr Val Thr Ala Thr Thr Ala Thr Thr Thr
            20                  25                  30          
Leu Met Met Thr Thr Ala Ser Met Ser Ser Met Ala Pro Thr Arg Phe
        35                  40                  45              
Ser His Trp Leu Asn Ile Pro Ala Ser Val Ser Cys Ser Arg Ile Pro
    50                  55                  60                  
Asp Ser Leu Lys Gln Arg Gly Leu Lys Lys Lys Lys Lys Lys Lys Lys
65                  70                  75                  80  
Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
                85                  90                  95      
Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
            100                 105                 110         
Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
        115                 120         


<210> 18
<211> 76
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic human DEFB-126 with deletion
      polymorphism frame shift C-terminal sequence,
      DEFB-126 variant polypeptide C-terminal sequence

<220> 
<221> VARIANT        
<222> (28)...(76)
<223> Lys may be present or absent

<400> 18
Arg Phe Ser His Trp Leu Asn Ile Pro Ala Ser Val Ser Cys Ser Arg
 1               5                  10                  15      
Ile Pro Asp Ser Leu Lys Gln Arg Gly Leu Lys Lys Lys Lys Lys Lys
            20                  25                  30          
Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
        35                  40                  45              
Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
    50                  55                  60                  
Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
65                  70                  75      


<210> 19
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic beta-defensin six-cysteine motif,
      canonical core of cysteine residues

<220> 
<221> VARIANT        
<222> (2)...(7)
<223> Xaa = any amino acid

<220> 
<221> VARIANT        
<222> (9)...(11)
<223> Xaa = any amino acid

<220> 
<221> VARIANT        
<222> (12)...(12)
<223> Xaa = any amino acid, may be present or absent

<220> 
<221> VARIANT        
<222> (14)...(22)
<223> Xaa = any amino acid

<220> 
<221> VARIANT        
<222> (23)...(25)
<223> Xaa = any amino acid, may be present or absent

<220> 
<221> VARIANT        
<222> (27)...(31)
<223> Xaa = any amino acid

<220> 
<221> VARIANT        
<222> (32)...(32)
<223> Xaa = any amino acid, may be present or absent

<400> 19
Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Cys Cys
        

<210> 20
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic human DEFB-126 with deletion polymorphism
      frame shift extended C-terminal sequence beginning motif,
      DEFB-126 variant polypeptide extended C-terminal sequence
      beginning motif

<220> 
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Ser or Leu

<220> 
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = Ala or Thr

<400> 20
Ser Met Ser Xaa Met Xaa
 1               5      


<210> 21
<211> 138
<212> PRT
<213> Homo sapiens

<220> 
<223> human DEFB-126 with deletion polymorphism frame
      shift, DEFB-126 variant polypeptide with extended
      C-terminal region

<400> 21
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly
            20                  25                  30          
Ile Cys Lys Lys Lys Cys Lys Pro Glu Glu Met His Val Lys Asn Gly
        35                  40                  45              
Trp Ala Met Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Arg
    50                  55                  60                  
Arg Ala Asn Tyr Pro Val Phe Cys Val Gln Thr Lys Thr Thr Arg Ile
65                  70                  75                  80  
Ser Thr Val Thr Ala Thr Thr Ala Thr Thr Thr Leu Met Met Thr Thr
                85                  90                  95      
Ala Ser Met Ser Ser Met Ala Pro Thr Arg Phe Ser His Trp Leu Asn
            100                 105                 110         
Ile Pro Ala Ser Val Ser Cys Ser Arg Ile Pro Asp Ser Leu Lys Gln
        115                 120                 125             
Arg Gly Leu Lys Lys Lys Lys Lys Lys Lys
    130                 135             


<210> 22
<211> 52
<212> PRT
<213> Artificial Sequence

<220> 
<223> human wild-type beta defensin 126 (DEFB-126,
      DEFB126, DEFB-26, DEFB26, hBD-26) C-terminal
      sequence

<400> 22
Val Pro Ala Asp Arg Arg Ala Asn Tyr Pro Val Phe Cys Val Gln Thr
 1               5                  10                  15      
Lys Thr Thr Arg Ile Ser Thr Val Thr Ala Thr Thr Ala Thr Thr Thr
            20                  25                  30          
Leu Met Met Thr Thr Ala Ser Met Ser Ser Met Ala Pro Thr Pro Val
        35                  40                  45              
Ser Pro Thr Gly
    50          


<210> 23
<211> 78
<212> PRT
<213> Artificial Sequence

<220> 
<223> human variant beta defensin 126 (DEFB-126) with deletion
      polymorphism frame shift C-terminal sequence

<400> 23
Val Pro Ala Asp Arg Arg Ala Asn Tyr Pro Val Phe Cys Val Gln Thr
 1               5                  10                  15      
Lys Thr Thr Arg Ile Ser Thr Val Thr Ala Thr Thr Ala Thr Thr Thr
            20                  25                  30          
Leu Met Met Thr Thr Ala Ser Met Ser Ser Met Ala Pro Thr Arg Phe
        35                  40                  45              
Ser His Trp Leu Asn Ile Pro Ala Ser Val Ser Cys Ser Arg Ile Pro
    50                  55                  60                  
Asp Ser Leu Lys Gln Arg Gly Leu Lys Lys Lys Lys Lys Lys
65                  70                  75              


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic wild-type human DEFB-126 nucleotide
      sequence spanning region encompassing DEFB-126
      deletion polymorphism, DEFB-126 subsequence

<400> 24
gctcctaccc ccgtttctcc                                             20

<210> 25
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic human variant DEFB-126 nucleotide sequence
      spanning region encompassing DEFB-126 deletion
      polymorphism, DEFB-126 subsequence with deletion
      polymorphism

<400> 25
gctcctaccc gtttctcc                                               18

<210> 26
<211> 46
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic wild-type human DEFB-126 polypeptide
      C-terminus sequence

<400> 26
Ala Asn Tyr Pro Val Phe Cys Val Gln Thr Lys Thr Thr Arg Ile Ser
 1               5                  10                  15      
Thr Val Thr Ala Thr Thr Ala Thr Thr Thr Leu Met Met Thr Thr Ala
            20                  25                  30          
Ser Met Ser Ser Met Ala Pro Thr Thr Val Ser Pro Thr Gly
        35                  40                  45      


<210> 27
<211> 74
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic human DEFB-126 with deletion
      polymorphism frame shift C-terminal sequence,
      DEFB-126 variant polypeptide C-terminal sequence

<400> 27
Ala Asn Tyr Pro Val Phe Cys Val Gln Thr Lys Thr Thr Arg Ile Ser
 1               5                  10                  15      
Thr Val Thr Ala Thr Thr Ala Thr Thr Thr Leu Met Met Thr Thr Ala
            20                  25                  30          
Ser Met Ser Ser Met Ala Pro Thr Arg Phe Ser His Trp Leu Asn Ile
        35                  40                  45              
Pro Ala Ser Val Ser Cys Ser Arg Ile Pro Asp Ser Leu Lys Gln Arg
    50                  55                  60                  
Gln Leu Lys Lys Lys Lys Lys Lys Lys Lys
65                  70                  


<210> 28
<211> 123
<212> PRT
<213> Macaca fascicularis

<220> 
<223> crab-eating macaque wild-type beta defensin 126
      (DEFB-126, DEFB126, DEFB-26, DEFB26)

<400> 28
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Asn Leu Tyr Val Lys Arg Cys Leu Asn Asp Ile Gly
            20                  25                  30          
Ile Cys Lys Lys Thr Cys Lys Pro Glu Glu Val Arg Ser Glu His Gly
        35                  40                  45              
Trp Val Met Cys Gly Lys Arg Lys Ala Cys Cys Val Pro Ala Asp Lys
    50                  55                  60                  
Arg Ser Ala Tyr Pro Ser Phe Cys Val His Ser Lys Thr Thr Lys Thr
65                  70                  75                  80  
Ser Thr Val Thr Ala Arg Ala Thr Ala Thr Thr Ala Thr Thr Ala Thr
                85                  90                  95      
Ala Ala Thr Pro Leu Met Ile Ser Asn Gly Leu Ile Ser Leu Met Thr
            100                 105                 110         
Thr Met Ala Ala Thr Pro Val Ser Pro Thr Thr
        115                 120             


<210> 29
<211> 134
<212> PRT
<213> Macaca fascicularis

<220> 
<223> crab-eating macaque wild-type beta defensin 126
      (DEFB-126, DEFB126, DEFB-26, DEFB26) amino acids
      1-134, cynomolgus macaque DEFB-126 amino acids 1-134 

<400> 29
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Asn Leu Tyr Val Lys Arg Cys Leu Asn Asp Ile Gly
            20                  25                  30          
Ile Cys Lys Lys Thr Cys Lys Pro Glu Glu Val Arg Ser Glu His Gly
        35                  40                  45              
Trp Val Met Cys Gly Lys Arg Lys Ala Cys Cys Val Pro Ala Asp Lys
    50                  55                  60                  
Arg Ser Ala Tyr Pro Ser Phe Cys Val His Ser Lys Thr Thr Lys Thr
65                  70                  75                  80  
Ser Thr Val Thr Ala Arg Ala Thr Ala Thr Thr Ala Thr Thr Ala Thr
                85                  90                  95      
Ala Ala Thr Pro Leu Met Ile Ser Asn Gly Leu Ile Ser Leu Met Ser
            100                 105                 110         
Tyr Asp Gly Arg Tyr Pro Cys Phe Ser His Tyr Leu Asn Ile Pro Ala
        115                 120                 125             
Ser Val Ser Cys Ser Arg
    130                 


<210> 30
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> human DEFB-126 variant polypeptide with extended
      C-terminal region residues 1-121

<400> 30
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly
            20                  25                  30          
Ile Cys Lys Lys Lys Cys Lys Pro Glu Glu Met His Val Lys Asn Gly
        35                  40                  45              
Trp Ala Met Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Arg
    50                  55                  60                  
Arg Ala Asn Tyr Pro Val Phe Cys Val Gln Thr Lys Thr Thr Arg Ile
65                  70                  75                  80  
Ser Thr Val Thr Ala Thr Thr Ala Thr Thr Thr Leu Met Met Thr Thr
                85                  90                  95      
Ala Ser Met Ser Ser Met Ala Pro Thr Arg Phe Ser His Trp Leu Asn
            100                 105                 110         
Ile Pro Ala Ser Val Ser Cys Ser Arg
        115                 120     


<210> 31
<211> 134
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic DEFB-126 polypeptide consensus sequence

<220> 
<221> VARIANT        
<222> (22)...(22)
<223> Xaa = Leu or Trp

<220> 
<221> VARIANT        
<222> (26)...(26)
<223> Xaa = Arg or Lys

<220> 
<221> VARIANT        
<222> (31)...(31)
<223> Xaa = Ile or Val

<220> 
<221> VARIANT        
<222> (37)...(37)
<223> Xaa = Thr or Lys

<220> 
<221> VARIANT        
<222> (43)...(43)
<223> Xaa = Val or Met

<220> 
<221> VARIANT        
<222> (44)...(44)
<223> Xaa = Arg or His

<220> 
<221> VARIANT        
<222> (45)...(45)
<223> Xaa = Ser or Val

<220> 
<221> VARIANT        
<222> (46)...(46)
<223> Xaa = Glu or Lys

<220> 
<221> VARIANT        
<222> (47)...(47)
<223> Xaa = His or Asn

<220> 
<221> VARIANT        
<222> (50)...(50)
<223> Xaa = Val or Ala

<220> 
<221> VARIANT        
<222> (55)...(55)
<223> Xaa = Arg or Gln

<220> 
<221> VARIANT        
<222> (56)...(56)
<223> Xaa = Lys or Arg

<220> 
<221> VARIANT        
<222> (57)...(57)
<223> Xaa = Ala or Asp

<220> 
<221> VARIANT        
<222> (64)...(64)
<223> Xaa = Lys or Arg

<220> 
<221> VARIANT        
<222> (66)...(66)
<223> Xaa = Ser or Ala

<220> 
<221> VARIANT        
<222> (67)...(67)
<223> Xaa = Ala or Asn

<220> 
<221> VARIANT        
<222> (70)...(70)
<223> Xaa = Ser or Val

<220> 
<221> VARIANT        
<222> (74)...(74)
<223> Xaa = His or Gln

<220> 
<221> VARIANT        
<222> (75)...(75)
<223> Xaa = Ser or Thr

<220> 
<221> VARIANT        
<222> (79)...(79)
<223> Xaa = Lys or Arg

<220> 
<221> VARIANT        
<222> (80)...(80)
<223> Xaa = Thr or Ile

<220> 
<221> VARIANT        
<222> (86)...(86)
<223> Xaa = Arg or Thr

<220> 
<221> VARIANT        
<222> (87)...(87)
<223> Xaa = Ala or Thr

<220> 
<221> VARIANT        
<222> (88)...(88)
<223> Xaa = Thr or Ala

<220> 
<221> VARIANT        
<222> (89)...(89)
<223> Xaa = Ala or Thr

<220> 
<221> VARIANT        
<222> (92)...(92)
<223> Xaa = Ala or Leu

<220> 
<221> VARIANT        
<222> (93)...(94)
<223> Xaa = Thr or Met

<220> 
<221> VARIANT        
<222> (95)...(95)
<223> Xaa = Ala or Thr

<220> 
<221> VARIANT        
<222> (98)...(98)
<223> Xaa = Ala or Ser

<220> 
<221> VARIANT        
<222> (99)...(99)
<223> Xaa = Thr or Met

<220> 
<221> VARIANT        
<222> (100)...(100)
<223> Xaa = Pro or Ser

<220> 
<221> VARIANT        
<222> (101)...(101)
<223> Xaa = Leu or Ser

<220> 
<221> VARIANT        
<222> (103)...(103)
<223> Xaa = Ile or Ala

<220> 
<221> VARIANT        
<222> (104)...(104)
<223> Xaa = Ser or Pro

<220> 
<221> VARIANT        
<222> (105)...(105)
<223> Xaa = Asn or Thr

<220> 
<221> VARIANT        
<222> (106)...(106)
<223> Xaa = Gly or Arg

<220> 
<221> VARIANT        
<222> (107)...(107)
<223> Xaa = Leu or absent

<220> 
<221> VARIANT        
<222> (108)...(108)
<223> Xaa = Ile or absent

<220> 
<221> VARIANT        
<222> (109)...(109)
<223> Xaa = Ser or absent

<220> 
<221> VARIANT        
<222> (110)...(110)
<223> Xaa = Leu or absent

<220> 
<221> VARIANT        
<222> (111)...(111)
<223> Xaa = Met or absent

<220> 
<221> VARIANT        
<222> (112)...(112)
<223> Xaa = Ser or absent

<220> 
<221> VARIANT        
<222> (113)...(113)
<223> Xaa = Tyr or absent

<220> 
<221> VARIANT        
<222> (114)...(114)
<223> Xaa = Asp or absent

<220> 
<221> VARIANT        
<222> (115)...(115)
<223> Xaa = Gly or absent

<220> 
<221> VARIANT        
<222> (116)...(116)
<223> Xaa = Arg or absent

<220> 
<221> VARIANT        
<222> (117)...(117)
<223> Xaa = Tyr or absent

<220> 
<221> VARIANT        
<222> (118)...(118)
<223> Xaa = Pro or absent

<220> 
<221> VARIANT        
<222> (119)...(119)
<223> Xaa = Cys or absent

<220> 
<221> VARIANT        
<222> (123)...(123)
<223> Xaa = Tyr or Trp

<400> 31
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly Asn Xaa Tyr Val Lys Xaa Cys Leu Asn Asp Xaa Gly
            20                  25                  30          
Ile Cys Lys Lys Xaa Cys Lys Pro Glu Glu Xaa Xaa Xaa Xaa Xaa Gly
        35                  40                  45              
Trp Xaa Met Cys Gly Lys Xaa Xaa Xaa Cys Cys Val Pro Ala Asp Xaa
    50                  55                  60                  
Arg Xaa Xaa Tyr Pro Xaa Phe Cys Val Xaa Xaa Lys Thr Thr Xaa Xaa
65                  70                  75                  80  
Ser Thr Val Thr Ala Xaa Xaa Xaa Xaa Thr Thr Xaa Xaa Xaa Xaa Thr
                85                  90                  95      
Ala Xaa Xaa Xaa Xaa Met Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Ser His Xaa Leu Asn Ile Pro Ala
        115                 120                 125             
Ser Val Ser Cys Ser Arg
    130                 


<210> 32
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic crab-eating macaque wild-type beta
      defensin 126 (DEFB-126, DEFB126, DEFB-26, DEFB26)
      excluding signal sequence, amino acids 21-134,
      cynomolgus macaque DEFB-126 amino acids 21-134

<400> 32
Asn Leu Tyr Val Lys Arg Cys Leu Asn Asp Ile Gly Ile Cys Lys Lys
 1               5                  10                  15      
Thr Cys Lys Pro Glu Glu Val Arg Ser Glu His Gly Trp Val Met Cys
            20                  25                  30          
Gly Lys Arg Lys Ala Cys Cys Val Pro Ala Asp Lys Arg Ser Ala Tyr
        35                  40                  45              
Pro Ser Phe Cys Val His Ser Lys Thr Thr Lys Thr Ser Thr Val Thr
    50                  55                  60                  
Ala Arg Ala Thr Ala Thr Thr Ala Thr Thr Ala Thr Ala Ala Thr Pro
65                  70                  75                  80  
Leu Met Ile Ser Asn Gly Leu Ile Ser Leu Met Ser Tyr Asp Gly Arg
                85                  90                  95      
Tyr Pro Cys Phe Ser His Tyr Leu Asn Ile Pro Ala Ser Val Ser Cys
            100                 105                 110         
Ser Arg
        

<210> 33
<211> 101
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic human DEFB-126 variant polypeptide with
      extended C-terminal region excluding signal
      sequence, residues 21-121

<400> 33
Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly Ile Cys Lys Lys
 1               5                  10                  15      
Lys Cys Lys Pro Glu Glu Met His Val Lys Asn Gly Trp Ala Met Cys
            20                  25                  30          
Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Arg Arg Ala Asn Tyr
        35                  40                  45              
Pro Val Phe Cys Val Gln Thr Lys Thr Thr Arg Ile Ser Thr Val Thr
    50                  55                  60                  
Ala Thr Thr Ala Thr Thr Thr Leu Met Met Thr Thr Ala Ser Met Ser
65                  70                  75                  80  
Ser Met Ala Pro Thr Arg Phe Ser His Trp Leu Asn Ile Pro Ala Ser
                85                  90                  95      
Val Ser Cys Ser Arg
            100     


<210> 34
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic DEFB-126 polypeptide consensus sequence

<220> 
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Leu or Trp

<220> 
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = Arg or Lys

<220> 
<221> VARIANT        
<222> (11)...(11)
<223> Xaa = Ile or Val

<220> 
<221> VARIANT        
<222> (17)...(17)
<223> Xaa = Thr or Lys

<220> 
<221> VARIANT        
<222> (23)...(23)
<223> Xaa = Val or Met

<220> 
<221> VARIANT        
<222> (24)...(24)
<223> Xaa = Arg or His

<220> 
<221> VARIANT        
<222> (25)...(25)
<223> Xaa = Ser or Val

<220> 
<221> VARIANT        
<222> (26)...(26)
<223> Xaa = Glu or Lys

<220> 
<221> VARIANT        
<222> (27)...(27)
<223> Xaa = His or Asn

<220> 
<221> VARIANT        
<222> (30)...(30)
<223> Xaa = Val or Ala

<220> 
<221> VARIANT        
<222> (35)...(35)
<223> Xaa = Arg or Gln

<220> 
<221> VARIANT        
<222> (36)...(36)
<223> Xaa = Lys or Arg

<220> 
<221> VARIANT        
<222> (37)...(37)
<223> Xaa = Ala or Asp

<220> 
<221> VARIANT        
<222> (44)...(44)
<223> Xaa = Lys or Arg

<220> 
<221> VARIANT        
<222> (46)...(46)
<223> Xaa = Ser or Ala

<220> 
<221> VARIANT        
<222> (47)...(47)
<223> Xaa = Ala or Asn

<220> 
<221> VARIANT        
<222> (50)...(50)
<223> Xaa = Ser or Val

<220> 
<221> VARIANT        
<222> (54)...(54)
<223> Xaa = His or Gln

<220> 
<221> VARIANT        
<222> (55)...(55)
<223> Xaa = Ser or Thr

<220> 
<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Lys or Arg

<220> 
<221> VARIANT        
<222> (60)...(60)
<223> Xaa = Thr or Ile

<220> 
<221> VARIANT        
<222> (66)...(66)
<223> Xaa = Arg or Thr

<220> 
<221> VARIANT        
<222> (67)...(67)
<223> Xaa = Ala or Thr

<220> 
<221> VARIANT        
<222> (68)...(68)
<223> Xaa = Thr or Ala

<220> 
<221> VARIANT        
<222> (69)...(69)
<223> Xaa = Ala or Thr

<220> 
<221> VARIANT        
<222> (72)...(72)
<223> Xaa = Ala or Leu

<220> 
<221> VARIANT        
<222> (73)...(74)
<223> Xaa = Thr or Met

<220> 
<221> VARIANT        
<222> (75)...(75)
<223> Xaa = Ala or Thr

<220> 
<221> VARIANT        
<222> (78)...(78)
<223> Xaa = Ala or Ser

<220> 
<221> VARIANT        
<222> (79)...(79)
<223> Xaa = Thr or Met

<220> 
<221> VARIANT        
<222> (80)...(80)
<223> Xaa = Pro or Ser

<220> 
<221> VARIANT        
<222> (81)...(81)
<223> Xaa = Leu or Ser

<220> 
<221> VARIANT        
<222> (83)...(83)
<223> Xaa = Ile or Ala

<220> 
<221> VARIANT        
<222> (84)...(84)
<223> Xaa = Ser or Pro

<220> 
<221> VARIANT        
<222> (85)...(85)
<223> Xaa = Asn or Thr

<220> 
<221> VARIANT        
<222> (86)...(86)
<223> Xaa = Gly or Arg

<220> 
<221> VARIANT        
<222> (87)...(87)
<223> Xaa = Leu or absent

<220> 
<221> VARIANT        
<222> (88)...(88)
<223> Xaa = Ile or absent

<220> 
<221> VARIANT        
<222> (89)...(89)
<223> Xaa = Ser or absent

<220> 
<221> VARIANT        
<222> (90)...(90)
<223> Xaa = Leu or absent

<220> 
<221> VARIANT        
<222> (91)...(91)
<223> Xaa = Met or absent

<220> 
<221> VARIANT        
<222> (92)...(92)
<223> Xaa = Ser or absent

<220> 
<221> VARIANT        
<222> (93)...(93)
<223> Xaa = Tyr or absent

<220> 
<221> VARIANT        
<222> (94)...(94)
<223> Xaa = Asp or absent

<220> 
<221> VARIANT        
<222> (95)...(95)
<223> Xaa = Gly or absent

<220> 
<221> VARIANT        
<222> (96)...(96)
<223> Xaa = Arg or absent

<220> 
<221> VARIANT        
<222> (97)...(97)
<223> Xaa = Tyr or absent

<220> 
<221> VARIANT        
<222> (98)...(98)
<223> Xaa = Pro or absent

<220> 
<221> VARIANT        
<222> (99)...(99)
<223> Xaa = Cys or absent

<220> 
<221> VARIANT        
<222> (103)...(103)
<223> Xaa = Tyr or Trp

<400> 34
Asn Xaa Tyr Val Lys Xaa Cys Leu Asn Asp Xaa Gly Ile Cys Lys Lys
 1               5                  10                  15      
Xaa Cys Lys Pro Glu Glu Xaa Xaa Xaa Xaa Xaa Gly Trp Xaa Met Cys
            20                  25                  30          
Gly Lys Xaa Xaa Xaa Cys Cys Val Pro Ala Asp Xaa Arg Xaa Xaa Tyr
        35                  40                  45              
Pro Xaa Phe Cys Val Xaa Xaa Lys Thr Thr Xaa Xaa Ser Thr Val Thr
    50                  55                  60                  
Ala Xaa Xaa Xaa Xaa Thr Thr Xaa Xaa Xaa Xaa Thr Ala Xaa Xaa Xaa
65                  70                  75                  80  
Xaa Met Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                85                  90                  95      
Xaa Xaa Xaa Phe Ser His Xaa Leu Asn Ile Pro Ala Ser Val Ser Cys
            100                 105                 110         
Ser Arg
        

<210> 35
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic wild-type human DEFB-126 polypeptide
      C-terminal sequence

<400> 35
Thr Val Ser Pro Thr Gly
 1               5      


<210> 36
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic forward primer DEFB126-154s
      polynucleotide

<400> 36
aagaatggtt gggcaatgtg c                                           21

<210> 37
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic forward primer DEFB126-199s
      polynucleotide

<400> 37
gcaaacaaag ggactgctgt gttcc                                       25

<210> 38
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic reverse primer DEFB126-330a
      polynucleotide

<400> 38
aggagccatc gaagacatcg aagc                                        24

<210> 39
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic reverse primer DEFB126-409a
      polynucleotide

<400> 39
ccacaatgct ttaatgagtc ggg                                         23

<210> 40
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic forward primer DEFB126-278s
      polynucleotide

<400> 40
cagcaacaac aactttgatg atgac                                       25

<210> 41
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic forward primer DEFB126-441s
      polynucleotide

<400> 41
ccatcagcac tatgacccca ggac                                        24

<210> 42
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic reverse primer DEFB126-546a
      polynucleotide

<400> 42
gttggcagta tgtttggtgg aggtg                                       25

<210> 43
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic crab-eating macaque wild-type beta
      defensin 126 (DEFB-126, DEFB126, DEFB-26, DEFB26)
      signal peptide, residues 1-20

<400> 43
Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln
 1               5                  10                  15      
Leu Val Ser Gly
            20  


<210> 44
<211> 44
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic crab-eating macaque wild-type beta
      defensin 126 (DEFB-126, DEFB126, DEFB-26, DEFB26)
      beta-defensin core domain region, residues 21-64

<400> 44
Asn Leu Tyr Val Lys Arg Cys Leu Asn Asp Ile Gly Ile Cys Lys Lys
 1               5                  10                  15      
Thr Cys Lys Pro Glu Glu Val Arg Ser Glu His Gly Trp Val Met Cys
            20                  25                  30          
Gly Lys Arg Lys Ala Cys Cys Val Pro Ala Asp Lys
        35                  40                  


<210> 45
<211> 59
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic crab-eating macaque wild-type beta
      defensin 126 (DEFB-126, DEFB126, DEFB-26, DEFB26)
      extended carboxyl tail, residues 65-123

<400> 45
Arg Ser Ala Tyr Pro Ser Phe Cys Val His Ser Lys Thr Thr Lys Thr
 1               5                  10                  15      
Ser Thr Val Thr Ala Arg Ala Thr Ala Thr Thr Ala Thr Thr Ala Thr
            20                  25                  30          
Ala Ala Thr Pro Leu Met Ile Ser Asn Gly Leu Ile Ser Leu Met Thr
        35                  40                  45              
Thr Met Ala Ala Thr Pro Val Ser Pro Thr Thr
    50                  55                  

<210> 146
<211> 53
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic human defensin core

<400> 46
Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly Ile Cys Lys Lys
 1               5                  10                  15      
Lys Cys Lys Pro Glu Glu Met His Val Lys Asn Gly Trp Ala Met Cys
            20                  25                  30          
Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Arg Arg Ala Asn Tyr
        35                  40                  45              
Pro Val Phe Cys Val
    50              


<210> 47
<211> 53
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic cynomolgus macaque defensin core

<400> 47
Asn Leu Tyr Val Lys Arg Cys Leu Asn Asp Ile Gly Ile Cys Lys Lys
 1               5                  10                  15      
Thr Cys Lys Pro Glu Glu Val Arg Ser Glu His Gly Trp Val Met Cys
            20                  25                  30          
Gly Lys Arg Lys Ala Cys Cys Val Pro Ala Asp Lys Arg Ser Ala Tyr
        35                  40                  45              
Pro Ser Phe Cys Val
    50              


<210> 3
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic mouse defensin core

<400> 3
Gly Trp Tyr Val Lys Lys Cys Ala Asn Thr Leu Gly Asn Cys Arg Lys
 1               5                  10                  15      
Met Cys Arg Asp Gly Glu Lys Gln Thr Glu Pro Ala Thr Ser Lys Cys
            20                  25                  30          
Pro Ile Gly Lys Leu Cys Cys Val Leu Asp Phe Lys Ile Ser Gly His
        35                  40                  45              
Cys Gly
    50  


<210> 4
<211> 53
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic defensin core consensus sequence

<220> 
<221> VARIANT        
<222> (11)...(11)
<223> Xaa = Val, Ile or Leu

<220> 
<221> VARIANT        
<222> (17)...(17)
<223> Xaa = Lys, Thr or Met

<220> 
<221> VARIANT        
<222> (23)...(23)
<223> Xaa = Met, Val or Lys

<220> 
<221> VARIANT        
<222> (24)...(24)
<223> Xaa = His, Arg or Gln

<220> 
<221> VARIANT        
<222> (25)...(25)
<223> Xaa = Val, Ser or Thr

<220> 
<221> VARIANT        
<222> (27)...(27)
<223> Xaa = Asn, His or Pro

<220> 
<221> VARIANT        
<222> (30)...(30)
<223> Xaa = Ala, Val or Ser

<220> 
<221> VARIANT        
<222> (35)...(35)
<223> Xaa = Gln, Arg or Gly

<220> 
<221> VARIANT        
<222> (37)...(37)
<223> Xaa = Asp, Ala or Leu

<220> 
<221> VARIANT        
<222> (47)...(47)
<223> Xaa = Asn, Ala or absent

<220> 
<221> VARIANT        
<222> (50)...(50)
<223> Xaa = Val, Ser or Gly

<400> 4
Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Xaa Gly Ile Cys Lys Lys
 1               5                  10                  15      
Xaa Cys Lys Pro Glu Glu Xaa Xaa Xaa Glu Xaa Gly Trp Xaa Met Cys
            20                  25                  30          
Gly Lys Xaa Lys Xaa Cys Cys Val Pro Ala Asp Lys Arg Ser Xaa Tyr
        35                  40                  45              
Pro Xaa Phe Cys Val
    50              

