                         SEQUENCE LISTING

<110>  The Salk Institute for Biological Studies
       joint Center for Biosciences
       Choe, Senyon
       Allendorph, George
       Isaacs, Mike
 
<120>  DESIGNER LIGANDS OF TGF-BETA SUPERFAMILY

<130>  00024-006WO1

<140>  Not yet known
<141>  2010-02-24

<150>  US 61/155,066
<151>  2009-02-24

<160>  97    

<170>  PatentIn version 3.5

<210>  1
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BMP-2 polynucleotide coding sequence


<220>
<221>  CDS
<222>  (4)..(345)

<400>  1
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
    Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
    1               5                   10                  15            

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
                20                  25                  30                

att gtg gct ccc ccg ggg tat cac gcc ttt tac tgc cac gga gaa tgc        144
Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys           
            35                  40                  45                    

cct ttt cct ctg gct gat cat ctg aac tcc act aat cat gcc att gtt        192
Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val           
        50                  55                  60                        

cag acg ttg gtc aac tct gtt aac tct aag att cct aag gca tgc tgt        240
Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys           
    65                  70                  75                            

gtc ccg aca gaa ctc agt gct atc tcg atg ctg tac ctt gac gag aat        288
Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn           
80                  85                  90                  95            

gaa aag gtt gta tta aag aac tat cag gac atg gtt gtg gag ggt tgt        336
Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys           
                100                 105                 110               

ggg tgt cgc                                                            345
Gly Cys Arg                                                               
                                                                          


<210>  2
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg 
1               5                   10                  15      


His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile 
            20                  25                  30          


Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro 
        35                  40                  45              


Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln 
    50                  55                  60                  


Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val 
65                  70                  75                  80  


Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu 
                85                  90                  95      


Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly 
            100                 105                 110         


Cys Arg 
        


<210>  3
<211>  1281
<212>  DNA
<213>  Homo Sapiens


<220>
<221>  CDS
<222>  (1)..(1281)

<400>  3
atg ccc ttg ctt tgg ctg aga gga ttt ctg ttg gca agt tgc tgg att         48
Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile           
1               5                   10                  15                

ata gtg agg agt tcc ccc acc cca gga tcc gag ggg cac agc gcg gcc         96
Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala           
            20                  25                  30                    

ccc gac tgt ccg tcc tgt gcg ctg gcc gcc ctc cca aag gat gta ccc        144
Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro           
        35                  40                  45                        

aac tct cag cca gag atg gtg gag gcc gtc aag aag cac att tta aac        192
Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn           
    50                  55                  60                            

atg ctg cac ttg aag aag aga ccc gat gtc acc cag ccg gta ccc aag        240
Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys           
65                  70                  75                  80            

gcg gcg ctt ctg aac gcg atc aga aag ctt cat gtg ggc aaa gtc ggg        288
Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly           
                85                  90                  95                

gag aac ggg tat gtg gag ata gag gat gac att gga agg agg gca gaa        336
Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu           
            100                 105                 110                   

atg aat gaa ctt atg gag cag acc tcg gag atc atc acg ttt gcc gag        384
Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu           
        115                 120                 125                       

tca gga aca gcc agg aag acg ctg cac ttc gag att tcc aag gaa ggc        432
Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly           
    130                 135                 140                           

agt gac ctg tca gtg gtg gag cgt gca gaa gtc tgg ctc ttc cta aaa        480
Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys           
145                 150                 155                 160           

gtc ccc aag gcc aac agg acc agg acc aaa gtc acc atc cgc ctc ttc        528
Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe           
                165                 170                 175               

cag cag cag aag cac ccg cag ggc agc ttg gac aca ggg gaa gag gcc        576
Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala           
            180                 185                 190                   

gag gaa gtg ggc tta aag ggg gag agg agt gaa ctg ttg ctc tct gaa        624
Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu           
        195                 200                 205                       

aaa gta gta gac gct cgg aag agc acc tgg cat gtc ttc cct gtc tcc        672
Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser           
    210                 215                 220                           

agc agc atc cag cgg ttg ctg gac cag ggc aag agc tcc ctg gac gtt        720
Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val           
225                 230                 235                 240           

cgg att gcc tgt gag cag tgc cag gag agt ggc gcc agc ttg gtt ctc        768
Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu           
                245                 250                 255               

ctg ggc aag aag aag aag aaa gaa gag gag ggg gaa ggg aaa aag aag        816
Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys           
            260                 265                 270                   

ggc gga ggt gaa ggt ggg gca gga gca gat gag gaa aag gag cag tcg        864
Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser           
        275                 280                 285                       

cac aga cct ttc ctc atg ctg cag gcc cgg cag tct gaa gac cac cct        912
His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro           
    290                 295                 300                           

cat cgc cgg cgt cgg cgg ggc ttg gag tgt gat ggc aag gtc aac atc        960
His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile           
305                 310                 315                 320           

tgc tgt aag aaa cag ttc ttt gtc agt ttc aag gac atc ggc tgg aat       1008
Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn           
                325                 330                 335               

gac tgg atc att gct ccc tct ggc tat cat gcc aac tac tgc gag ggt       1056
Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly           
            340                 345                 350                   

gag tgc ccg agc cat ata gca ggc acg tcc ggg tcc tca ctg tcc ttc       1104
Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe           
        355                 360                 365                       

cac tca aca gtc atc aac cac tac cgc atg cgg ggc cat agc ccc ttt       1152
His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe           
    370                 375                 380                           

gcc aac ctc aaa tcg tgc tgt gtg ccc acc aag ctg aga ccc atg tcc       1200
Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser           
385                 390                 395                 400           

atg ttg tac tat gat gat ggt caa aac atc atc aaa aag gac att cag       1248
Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln           
                405                 410                 415               

aac atg atc gtg gag gag tgt ggg tgc tca tag                           1281
Asn Met Ile Val Glu Glu Cys Gly Cys Ser                                   
            420                 425                                       


<210>  4
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  4

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  5
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature activin polypeptide homo sapiens

<400>  5

Gly Leu Glu Cys Asp Gly Lys Val Asn Ile Cys Cys Lys Lys Gln Phe 
1               5                   10                  15      


Phe Val Ser Phe Lys Asp Ile Gly Trp Asn Asp Trp Ile Ile Ala Pro 
            20                  25                  30          


Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys Pro Ser His Ile 
        35                  40                  45              


Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser Thr Val Ile Asn 
    50                  55                  60                  


His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn Leu Lys Ser Cys 
65                  70                  75                  80  


Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr Tyr Asp Asp 
                85                  90                  95      


Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu 
            100                 105                 110         


Cys Gly Cys Ser 
        115     


<210>  6
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(345)

<400>  6
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

att gtg gct ccc ccg ggg tat cac gcc ttt tac tgc cac gga gaa tgc        144
Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys           
        35                  40                  45                        

cct ttt cct ctg gct gat cat ctg aac tcc act aat cat gcc att gtt        192
Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val           
    50                  55                  60                            

cag acg ttg gtc aac tct gtt aac tct aag att cct aag gca tgc tgt        240
Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys           
65                  70                  75                  80            

gtc ccg aca gaa ctc agt gct atc tcg atg ttg tac tat gat gat ggt        288
Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Tyr Asp Asp Gly           
                85                  90                  95                

cga aac atc atc aaa aag gac att cag aac atg atc gtg gag gag tgt        336
Arg Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu Cys           
            100                 105                 110                   

ggg tgc tca                                                            345
Gly Cys Ser                                                               
        115                                                               


<210>  7
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys 
        35                  40                  45              


Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val 
    50                  55                  60                  


Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys 
65                  70                  75                  80  


Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Tyr Asp Asp Gly 
                85                  90                  95      


Arg Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu Cys 
            100                 105                 110         


Gly Cys Ser 
        115 


<210>  8
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(342)

<400>  8
atg caa gcc aaa cac caa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Gln Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

att gtg gct ccc ccg ggg tat cac gcc ttt tac tgc cac gga gaa tgc        144
Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys           
        35                  40                  45                        

cct ttt cct ctg gct gat cat ctg aac tcc act aat cat gcc att gtt        192
Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val           
    50                  55                  60                            

cag acg ttg gtc aac tct gtt aac tct aag att cct aag gca tgc tgt        240
Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys           
65                  70                  75                  80            

gtc ccg acc aag ctg aga ccc tcc atg ttg tac tat gat gat ggt caa        288
Val Pro Thr Lys Leu Arg Pro Ser Met Leu Tyr Tyr Asp Asp Gly Gln           
                85                  90                  95                

aac atc atc aaa aag gac att cag aac atg atc gtg gag gag tgt ggg        336
Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu Cys Gly           
            100                 105                 110                   

tgc tca                                                                342
Cys Ser                                                                   
                                                                          


<210>  9
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Met Gln Ala Lys His Gln Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys 
        35                  40                  45              


Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val 
    50                  55                  60                  


Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys 
65                  70                  75                  80  


Val Pro Thr Lys Leu Arg Pro Ser Met Leu Tyr Tyr Asp Asp Gly Gln 
                85                  90                  95      


Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu Cys Gly 
            100                 105                 110         


Cys Ser 
        


<210>  10
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(345)

<400>  10
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

att gtg gct ccc ccg ggg tat cac gcc ttt tac tgc cac gga gaa tgc        144
Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys           
        35                  40                  45                        

cct ttt cct ctg gct gat cat ctg aac tcc act aat cat gcc att gtt        192
Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val           
    50                  55                  60                            

cag acg ttg gtc aac tct gtt aac tct aag att cct aag gca tgc tgt        240
Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys           
65                  70                  75                  80            

gtc ccg acc aag ctg aga ccc atg tcc atg ttg tac tat gat gag aat        288
Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr Tyr Asp Glu Asn           
                85                  90                  95                

gaa aag gtt gta tta aag aac tat cag gac atg gtt gtg gag ggt tgt        336
Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys           
            100                 105                 110                   

ggg tgt cgc                                                            345
Gly Cys Arg                                                               
        115                                                               


<210>  11
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys 
        35                  40                  45              


Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val 
    50                  55                  60                  


Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys 
65                  70                  75                  80  


Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr Tyr Asp Glu Asn 
                85                  90                  95      


Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys 
            100                 105                 110         


Gly Cys Arg 
        115 


<210>  12
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(360)

<400>  12
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

att gtg gct ccc ccg ggg tat cac gcc ttt tac tgc cac gga gaa tgc        144
Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys           
        35                  40                  45                        

cct tct cat ata gca ggc acg tcc ggg tcc tca ctg tcc ttc cac tca        192
Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser           
    50                  55                  60                            

acg ttg gtc aac cac tac cgc atg cgg ggc cat agc ccc ttt gcc aac        240
Thr Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn           
65                  70                  75                  80            

ctc aaa tcg tgc tgt gtc ccg acc aag ctg aga ccc atg tcc atg ttg        288
Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu           
                85                  90                  95                

tac tat gat gat ggt caa aac atc atc aaa aag gac att cag aac atg        336
Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met           
            100                 105                 110                   

atc gtg gag gag tgt ggg tgc tca                                        360
Ile Val Glu Glu Cys Gly Cys Ser                                           
        115                 120                                           


<210>  13
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys 
        35                  40                  45              


Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser 
    50                  55                  60                  


Thr Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn 
65                  70                  75                  80  


Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu 
                85                  90                  95      


Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met 
            100                 105                 110         


Ile Val Glu Glu Cys Gly Cys Ser 
        115                 120 


<210>  14
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(360)

<400>  14
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

att gtg gct ccc ccg ggg tat cac gcc ttt tac tgc cac gga gaa tgc        144
Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys           
        35                  40                  45                        

cct tct cat ata gca ggc acg tcc ggg tcc tca ctg tcc tta cac tca        192
Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Leu His Ser           
    50                  55                  60                            

acg ttg gtc aac cac tac cgc atg cgg ggc cat agc ccc ttt gcc aac        240
Thr Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn           
65                  70                  75                  80            

ctc aaa tcg tgc tgt gtc ccg aca gag ctc agt gct atc tcg atg ttg        288
Leu Lys Ser Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu           
                85                  90                  95                

tac tat gat gat ggt caa aac atc atc aaa aag gac att cag aac atg        336
Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met           
            100                 105                 110                   

atc gtg gag gag tgt ggg tgc tca                                        360
Ile Val Glu Glu Cys Gly Cys Ser                                           
        115                 120                                           


<210>  15
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys 
        35                  40                  45              


Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Leu His Ser 
    50                  55                  60                  


Thr Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn 
65                  70                  75                  80  


Leu Lys Ser Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
                85                  90                  95      


Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met 
            100                 105                 110         


Ile Val Glu Glu Cys Gly Cys Ser 
        115                 120 


<210>  16
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(360)

<400>  16
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

atc att gct ccc tct ggc tat cat gcc aac tac tgc gag gga gaa tgc        144
Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys           
        35                  40                  45                        

cct tcc cat ata gca ggc acg tcc ggg tcc tca ctg tcc ttc cat tca        192
Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser           
    50                  55                  60                            

acg ttg gtc aac cac tac cgc atg cgg ggc cat agc ccc ttt gcc aac        240
Thr Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn           
65                  70                  75                  80            

ctc aaa tcg tgc tgt gtc ccg acc aag ctg aga ccc atg tcc atg ttg        288
Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu           
                85                  90                  95                

tac tat gat gat ggt caa aac atc atc aaa aag gac att cag aac atg        336
Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met           
            100                 105                 110                   

atc gtg gag gag tgt ggg tgc tca                                        360
Ile Val Glu Glu Cys Gly Cys Ser                                           
        115                 120                                           


<210>  17
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys 
        35                  40                  45              


Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser 
    50                  55                  60                  


Thr Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn 
65                  70                  75                  80  


Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu 
                85                  90                  95      


Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met 
            100                 105                 110         


Ile Val Glu Glu Cys Gly Cys Ser 
        115                 120 


<210>  18
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(360)

<400>  18
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

atc att gct ccc tct ggc tat cat gcc aac tac tgc gag gga gaa tgc        144
Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys           
        35                  40                  45                        

cct tcc cat ata gca ggc acg tcc ggg tcc tca ctg tcc ttc cat tca        192
Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser           
    50                  55                  60                            

acg gtg atc aac cac tac cgc atg cgg ggc cat agc ccc ttt gcc aac        240
Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn           
65                  70                  75                  80            

ctc aaa tcg tgc tgt gtc ccg acc aag ctg aga ccc atg tcc atg ttg        288
Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu           
                85                  90                  95                

tac tat gat gat ggt caa aac atc atc aaa aag gac att cag aac atg        336
Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met           
            100                 105                 110                   

atc gtg gag gag tgt ggg tgc tca                                        360
Ile Val Glu Glu Cys Gly Cys Ser                                           
        115                 120                                           


<210>  19
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys 
        35                  40                  45              


Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser 
    50                  55                  60                  


Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn 
65                  70                  75                  80  


Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu 
                85                  90                  95      


Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met 
            100                 105                 110         


Ile Val Glu Glu Cys Gly Cys Ser 
        115                 120 


<210>  20
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(357)

<400>  20
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aaa cag ttc ttt gtc agt ttc aag gac atc ggg tgg aat gac tgg atc         96
Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn Asp Trp Ile           
            20                  25                  30                    

att gct ccc tct ggc tat cat gcc aac tac tgc gag gga gaa tgc cct        144
Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys Pro           
        35                  40                  45                        

tcc cat ata gca ggc acg tcc ggg tcc tca ctg tcc ttc cat tca acg        192
Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser Thr           
    50                  55                  60                            

ttg gtc aac cac tac cgc atg cgg ggc cat agc ccc ttt gcc aac ctc        240
Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn Leu           
65                  70                  75                  80            

aaa tcg tgc tgt gtc ccg acc aag ctg aga ccc atg tcc atg ttg tac        288
Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr           
                85                  90                  95                

tat gat gat ggt caa aac atc atc aaa aag gac att cag aac atg atc        336
Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile           
            100                 105                 110                   

gtg gag gag tgt ggg tgc tca                                            357
Val Glu Glu Cys Gly Cys Ser                                               
        115                                                               


<210>  21
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn Asp Trp Ile 
            20                  25                  30          


Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys Pro 
        35                  40                  45              


Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser Thr 
    50                  55                  60                  


Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn Leu 
65                  70                  75                  80  


Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile 
            100                 105                 110         


Val Glu Glu Cys Gly Cys Ser 
        115                 


<210>  22
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(360)

<400>  22
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

atc att gct ccc tct ggc tat cat gcc aac tac tgc gag gga gaa tgc        144
Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys           
        35                  40                  45                        

cct tct cat ata gca ggc acg tcc ggg tcc tca ctg tcc ttc cac tca        192
Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser           
    50                  55                  60                            

acg ttg gtc aac cac tac cgc atg cgg ggc cat agc ccc ttt gcc aac        240
Thr Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn           
65                  70                  75                  80            

ctc aaa tcg tgc tgt gtc ccg acc aag ctg aga ccc atg tcc atg ttg        288
Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu           
                85                  90                  95                

tac ctt gac gag aat gaa aag gtt gta tta aag aac tat cag gac atg        336
Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met           
            100                 105                 110                   

gtt gtg gag ggt tgt ggg tgt cgc                                        360
Val Val Glu Gly Cys Gly Cys Arg                                           
        115                 120                                           


<210>  23
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys 
        35                  40                  45              


Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser 
    50                  55                  60                  


Thr Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn 
65                  70                  75                  80  


Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu 
                85                  90                  95      


Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met 
            100                 105                 110         


Val Val Glu Gly Cys Gly Cys Arg 
        115                 120 


<210>  24
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(360)

<400>  24
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

atc att gct ccc tct ggc tat cat gcc aac tac tgc gag gga gaa tgc        144
Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys           
        35                  40                  45                        

cct tct cat ata gca ggc acg tcc ggg tcc tca ctg tcc ttc cac tca        192
Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser           
    50                  55                  60                            

acg ttg gtc aac cac tac cgc atg cgg ggc cat agc ccc ttt gcc aac        240
Thr Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn           
65                  70                  75                  80            

ctc aaa tcg tgc tgt gtc ccg aca gaa ctc agt gct atc tcg atg ttg        288
Leu Lys Ser Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu           
                85                  90                  95                

tac ctt gac gag aat gaa aag gtt gta tta aag aac tat cag gac atg        336
Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met           
            100                 105                 110                   

gtt gtg gag ggt tgt ggg tgt cgc                                        360
Val Val Glu Gly Cys Gly Cys Arg                                           
        115                 120                                           


<210>  25
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys 
        35                  40                  45              


Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser 
    50                  55                  60                  


Thr Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn 
65                  70                  75                  80  


Leu Lys Ser Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
                85                  90                  95      


Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met 
            100                 105                 110         


Val Val Glu Gly Cys Gly Cys Arg 
        115                 120 


<210>  26
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(360)

<400>  26
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

atc att gct ccc tct ggc tat cat gcc aac tac tgc gag gga gaa tgc        144
Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys           
        35                  40                  45                        

cct tct cat ata gca ggc acg tcc ggg tcc tca ctg tcc ttc cac tca        192
Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser           
    50                  55                  60                            

acg ttg gtc aac cac tac cgc atg cgg ggc cat agc ccc ttt gcc aac        240
Thr Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn           
65                  70                  75                  80            

ctc aaa tcg tgc tgt gtc ccg aca gaa ctc agt gct atc tcg atg ttg        288
Leu Lys Ser Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu           
                85                  90                  95                

tac tat gat gat ggt caa aac atc atc aaa aag gac att cag aac atg        336
Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met           
            100                 105                 110                   

atc gtg gag gag tgt ggg tgc tca                                        360
Ile Val Glu Glu Cys Gly Cys Ser                                           
        115                 120                                           


<210>  27
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys 
        35                  40                  45              


Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser 
    50                  55                  60                  


Thr Leu Val Asn His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn 
65                  70                  75                  80  


Leu Lys Ser Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
                85                  90                  95      


Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met 
            100                 105                 110         


Ile Val Glu Glu Cys Gly Cys Ser 
        115                 120 


<210>  28
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(345)

<400>  28
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

atc att gct ccc tct ggc tat cat gcc aac tac tgc gac gga gaa tgc        144
Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Asp Gly Glu Cys           
        35                  40                  45                        

cct ttt cct ctg gct gat cat ctg aac tcc act aat cat gcc att gtt        192
Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val           
    50                  55                  60                            

cag acg ttg gtc aac tct gtt aac tct aag att cct aag gca tgc tgt        240
Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys           
65                  70                  75                  80            

gtc ccg aca gaa ctc agt gct atc tcg atg ttg tac tat gat gat ggt        288
Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Tyr Asp Asp Gly           
                85                  90                  95                

caa aac atc atc aaa aag gac att cag aac atg atc gtg gag gag tgt        336
Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu Cys           
            100                 105                 110                   

ggg tgc tca                                                            345
Gly Cys Ser                                                               
        115                                                               


<210>  29
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Asp Gly Glu Cys 
        35                  40                  45              


Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val 
    50                  55                  60                  


Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys 
65                  70                  75                  80  


Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Tyr Asp Asp Gly 
                85                  90                  95      


Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu Cys 
            100                 105                 110         


Gly Cys Ser 
        115 


<210>  30
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(345)

<400>  30
atg caa gcc aaa cac aaa cag cgg aag cgt ctt aag tcc agc tgc aaa         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

agg cac cct ttg tat gtg gac ttc agt gat gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

atc att gct ccc tct ggc tat cat gcc aac tac tgc gac gga gaa tgc        144
Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Asp Gly Glu Cys           
        35                  40                  45                        

cct ttt cct ctg gct gat cat ctg aac tcc act aat cat gcc att gtt        192
Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val           
    50                  55                  60                            

cag acg ttg gtc aac tct gtt aac tct aag att cct aag gca tgc tgt        240
Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys           
65                  70                  75                  80            

gtc ccg acc aag ctg aga ccc atg tcc atg ttg tac tat gat gat ggt        288
Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr Tyr Asp Asp Gly           
                85                  90                  95                

caa aac atc atc aaa aag gac att cag aac atg atc gtg gag gag tgt        336
Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu Cys           
            100                 105                 110                   

ggg tgc tca                                                            345
Gly Cys Ser                                                               
        115                                                               


<210>  31
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Asp Gly Glu Cys 
        35                  40                  45              


Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val 
    50                  55                  60                  


Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys 
65                  70                  75                  80  


Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr Tyr Asp Asp Gly 
                85                  90                  95      


Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu Cys 
            100                 105                 110         


Gly Cys Ser 
        115 


<210>  32
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(345)

<400>  32
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

atc att gct ccc tct ggc tat cat gcc aac tac tgc gac gga gaa tgc        144
Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Asp Gly Glu Cys           
        35                  40                  45                        

cct ttt cct ctg gct gat cat ctg aac tcc act aat cat gcc att gtt        192
Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val           
    50                  55                  60                            

cag acg ttg gtc aac tct gtt aac tct aag att cct aag gca tgc tgt        240
Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys           
65                  70                  75                  80            

gtc ccg acc aag ctg aga ccc atg tcc atg ttg tac ctt gac gag aat        288
Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr Leu Asp Glu Asn           
                85                  90                  95                

gaa aag gtt gta tta aag aac tat cag gac atg gtt gtg gag ggt tgt        336
Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys           
            100                 105                 110                   

ggg tgt cgc                                                            345
Gly Cys Arg                                                               
        115                                                               


<210>  33
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Asp Gly Glu Cys 
        35                  40                  45              


Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val 
    50                  55                  60                  


Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys 
65                  70                  75                  80  


Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr Leu Asp Glu Asn 
                85                  90                  95      


Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys 
            100                 105                 110         


Gly Cys Arg 
        115 


<210>  34
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(348)

<400>  34
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

att atc gcg cct gaa ggc tac gcc gcc tac tac tgt gag ggg gag tgt        144
Ile Ile Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys           
        35                  40                  45                        

gcc ttc cct ctg aac tcc tac atg aac gcc acc aac cac gcc atc gtg        192
Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val           
    50                  55                  60                            

cag acg ctg gtc cac ttc atc aac ccg gaa acg gtg ccc aag ccc tgc        240
Gln Thr Leu Val His Phe Ile Asn Pro Glu Thr Val Pro Lys Pro Cys           
65                  70                  75                  80            

tgt gcg ccc acg cag ctc aat gcc atc tcc gtc ctc tac ttc gat gac        288
Cys Ala Pro Thr Gln Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp           
                85                  90                  95                

agc tcc aac gtc atc ctg aag aaa tac aga aac atg gtg gtc cgg gcc        336
Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala           
            100                 105                 110                   

tgt ggc tgc cac                                                        348
Cys Gly Cys His                                                           
        115                                                               


<210>  35
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Ile Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys 
        35                  40                  45              


Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val 
    50                  55                  60                  


Gln Thr Leu Val His Phe Ile Asn Pro Glu Thr Val Pro Lys Pro Cys 
65                  70                  75                  80  


Cys Ala Pro Thr Gln Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp 
                85                  90                  95      


Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala 
            100                 105                 110         


Cys Gly Cys His 
        115     


<210>  36
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(351)

<400>  36
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

att att gcc cca aaa gag tac gag gca tac gag tgt aag ggc ggc tgt        144
Ile Ile Ala Pro Lys Glu Tyr Glu Ala Tyr Glu Cys Lys Gly Gly Cys           
        35                  40                  45                        

ttc ttt ccg ctg gcc gac gat gtc acc ccg acc aag cac gca att gtc        192
Phe Phe Pro Leu Ala Asp Asp Val Thr Pro Thr Lys His Ala Ile Val           
    50                  55                  60                            

caa acc tta gtg cac ctg aag ttc cca acg aaa gtg ggt aag gca tgt        240
Gln Thr Leu Val His Leu Lys Phe Pro Thr Lys Val Gly Lys Ala Cys           
65                  70                  75                  80            

tgt gtg cca acc aag tta tct cca att agc gtg ctg tat aag gat gat        288
Cys Val Pro Thr Lys Leu Ser Pro Ile Ser Val Leu Tyr Lys Asp Asp           
                85                  90                  95                

atg ggc gtg ccg acg tta aag tat cat tac gag ggc atg agc gtc gca        336
Met Gly Val Pro Thr Leu Lys Tyr His Tyr Glu Gly Met Ser Val Ala           
            100                 105                 110                   

gag tgt ggc tgc cgc                                                    351
Glu Cys Gly Cys Arg                                                       
        115                                                               


<210>  37
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Ile Ala Pro Lys Glu Tyr Glu Ala Tyr Glu Cys Lys Gly Gly Cys 
        35                  40                  45              


Phe Phe Pro Leu Ala Asp Asp Val Thr Pro Thr Lys His Ala Ile Val 
    50                  55                  60                  


Gln Thr Leu Val His Leu Lys Phe Pro Thr Lys Val Gly Lys Ala Cys 
65                  70                  75                  80  


Cys Val Pro Thr Lys Leu Ser Pro Ile Ser Val Leu Tyr Lys Asp Asp 
                85                  90                  95      


Met Gly Val Pro Thr Leu Lys Tyr His Tyr Glu Gly Met Ser Val Ala 
            100                 105                 110         


Glu Cys Gly Cys Arg 
        115         


<210>  38
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(348)

<400>  38
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

att atc gcg ccg ctg gac tac gag gcg tac cac tgc gag ggc cta tgc        144
Ile Ile Ala Pro Leu Asp Tyr Glu Ala Tyr His Cys Glu Gly Leu Cys           
        35                  40                  45                        

gat ttt cct ctg cgt tcg cac ctc gaa ccc acc aac cat gcc atc att        192
Asp Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn His Ala Ile Ile           
    50                  55                  60                            

cag acg ttg gtc aac tcc atg gca cca gac gcg gcg ccg gcc tcc tgc        240
Gln Thr Leu Val Asn Ser Met Ala Pro Asp Ala Ala Pro Ala Ser Cys           
65                  70                  75                  80            

tgt gtc ccg gcg cgc ctc agc ccc atc agc atc ttg tac tat gat gcc        288
Cys Val Pro Ala Arg Leu Ser Pro Ile Ser Ile Leu Tyr Tyr Asp Ala           
                85                  90                  95                

gcc aac aac gtt gtc tac aag caa tac gag gac atg gtg gtg gag gcc        336
Ala Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met Val Val Glu Ala           
            100                 105                 110                   

tgt ggg tgt cgc                                                        348
Cys Gly Cys Arg                                                           
        115                                                               


<210>  39
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Ile Ala Pro Leu Asp Tyr Glu Ala Tyr His Cys Glu Gly Leu Cys 
        35                  40                  45              


Asp Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn His Ala Ile Ile 
    50                  55                  60                  


Gln Thr Leu Val Asn Ser Met Ala Pro Asp Ala Ala Pro Ala Ser Cys 
65                  70                  75                  80  


Cys Val Pro Ala Arg Leu Ser Pro Ile Ser Ile Leu Tyr Tyr Asp Ala 
                85                  90                  95      


Ala Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met Val Val Glu Ala 
            100                 105                 110         


Cys Gly Cys Arg 
        115     


<210>  40
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric polypeptide


<220>
<221>  CDS
<222>  (1)..(330)

<400>  40
atg caa gcc aaa cac aaa cag cgg aaa cgc ctt aag tcc agc tgt aag         48
Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys           
1               5                   10                  15                

aga cac cct ttg tac gtg gac ttc agt gac gtg ggg tgg aat gac tgg         96
Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp           
            20                  25                  30                    

att att gca ccc aaa aga tat aag gcc aat tac tgc tct gga gag tgt        144
Ile Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu Cys           
        35                  40                  45                        

gaa ttt gta ttt tta caa aaa tac cct cac act cat ctt gtg cac caa        192
Glu Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln           
    50                  55                  60                            

gca aac ccc aga ggt tca gca ggc ccc tgc tgt act ccc aca aag atg        240
Ala Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met           
65                  70                  75                  80            

tct cca atc aat atg cta tat ttt aat ggc aaa gaa caa ata ata tat        288
Ser Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile Ile Tyr           
                85                  90                  95                

ggg aaa att cca gcc atg gta gta gat cgc tgt ggg tgc tca                330
Gly Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser                   
            100                 105                 110                   


<210>  41
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Met Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
1               5                   10                  15      


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
            20                  25                  30          


Ile Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu Cys 
        35                  40                  45              


Glu Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln 
    50                  55                  60                  


Ala Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met 
65                  70                  75                  80  


Ser Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile Ile Tyr 
                85                  90                  95      


Gly Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser 
            100                 105                 110 


<210>  42
<211>  330
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)

<400>  42
cag tgg att gaa cct cgg aat tgc gcc agg aga tac ctc aag gta gac         48
Gln Trp Ile Glu Pro Arg Asn Cys Ala Arg Arg Tyr Leu Lys Val Asp           
1               5                   10                  15                

ttt gca gat att ggc tgg agt gaa tgg att atc tcc ccc aag tcc ttt         96
Phe Ala Asp Ile Gly Trp Ser Glu Trp Ile Ile Ser Pro Lys Ser Phe           
            20                  25                  30                    

gat gcc tat tat tgc tct gga gca tgc cag ttc ccc atg cca aag tct        144
Asp Ala Tyr Tyr Cys Ser Gly Ala Cys Gln Phe Pro Met Pro Lys Ser           
        35                  40                  45                        

ttg aag cca tca aat cat gct acc atc cag agt ata gtg aga gct gtg        192
Leu Lys Pro Ser Asn His Ala Thr Ile Gln Ser Ile Val Arg Ala Val           
    50                  55                  60                            

ggg gtc gtt cct ggg att cct gag cct tgc tgt gta cca gaa aag atg        240
Gly Val Val Pro Gly Ile Pro Glu Pro Cys Cys Val Pro Glu Lys Met           
65                  70                  75                  80            

tcc tca ctc agt att tta ttc ttt gat gaa aat aag aat gta gtg ctt        288
Ser Ser Leu Ser Ile Leu Phe Phe Asp Glu Asn Lys Asn Val Val Leu           
                85                  90                  95                

aaa gta tac cct aac atg aca gta gag tct tgc gct tgc aga                330
Lys Val Tyr Pro Asn Met Thr Val Glu Ser Cys Ala Cys Arg                   
            100                 105                 110                   


<210>  43
<211>  110
<212>  PRT
<213>  homo sapiens

<400>  43

Gln Trp Ile Glu Pro Arg Asn Cys Ala Arg Arg Tyr Leu Lys Val Asp 
1               5                   10                  15      


Phe Ala Asp Ile Gly Trp Ser Glu Trp Ile Ile Ser Pro Lys Ser Phe 
            20                  25                  30          


Asp Ala Tyr Tyr Cys Ser Gly Ala Cys Gln Phe Pro Met Pro Lys Ser 
        35                  40                  45              


Leu Lys Pro Ser Asn His Ala Thr Ile Gln Ser Ile Val Arg Ala Val 
    50                  55                  60                  


Gly Val Val Pro Gly Ile Pro Glu Pro Cys Cys Val Pro Glu Lys Met 
65                  70                  75                  80  


Ser Ser Leu Ser Ile Leu Phe Phe Asp Glu Asn Lys Asn Val Val Leu 
                85                  90                  95      


Lys Val Tyr Pro Asn Met Thr Val Glu Ser Cys Ala Cys Arg 
            100                 105                 110 


<210>  44
<211>  348
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(348)

<400>  44
agc cct aag cat cac tca cag cgg gcc agg aag aag aat aag aac tgc         48
Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys Asn Lys Asn Cys           
1               5                   10                  15                

cgg cgc cac tcg ctc tat gtg gac ttc agc gat gtg ggc tgg aat gac         96
Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp           
            20                  25                  30                    

tgg att gtg gcc cca cca ggc tac cag gcc ttc tac tgc cat ggg gac        144
Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr Cys His Gly Asp           
        35                  40                  45                        

tgc ccc ttt cca ctg gct gac cac ctc aac tca acc aac cat gcc att        192
Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile           
    50                  55                  60                            

gtg cag acc ctg gtc aat tct gtc aat tcc agt atc ccc aaa gcc tgt        240
Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile Pro Lys Ala Cys           
65                  70                  75                  80            

tgt gtg ccc act gaa ctg agt gcc atc tcc atg ctg tac ctg gat gag        288
Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu           
                85                  90                  95                

tat gat aag gtg gta ctg aaa aat tat cag gag atg gta gta gag gga        336
Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met Val Val Glu Gly           
            100                 105                 110                   

tgt ggg tgc cgc                                                        348
Cys Gly Cys Arg                                                           
        115                                                               


<210>  45
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  45

Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys Asn Lys Asn Cys 
1               5                   10                  15      


Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
            20                  25                  30          


Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr Cys His Gly Asp 
        35                  40                  45              


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
    50                  55                  60                  


Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile Pro Lys Ala Cys 
65                  70                  75                  80  


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
                85                  90                  95      


Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met Val Val Glu Gly 
            100                 105                 110         


Cys Gly Cys Arg 
        115     


<210>  46
<211>  414
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(414)

<400>  46
gca gcc aac aaa cga aaa aat caa aac cgc aat aaa tcc agc tct cat         48
Ala Ala Asn Lys Arg Lys Asn Gln Asn Arg Asn Lys Ser Ser Ser His           
1               5                   10                  15                

cag gac tcc tcc aga atg tcc agt gtt gga gat tat aac aca agt gag         96
Gln Asp Ser Ser Arg Met Ser Ser Val Gly Asp Tyr Asn Thr Ser Glu           
            20                  25                  30                    

caa aaa caa gcc tgt aag aag cac gaa ctc tat gtg agc ttc cgg gat        144
Gln Lys Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg Asp           
        35                  40                  45                        

ctg gga tgg cag gac tgg att ata gca cca gaa gga tac gct gca ttt        192
Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Phe           
    50                  55                  60                            

tat tgt gat gga gaa tgt tct ttt cca ctt aac gcc cat atg aat gcc        240
Tyr Cys Asp Gly Glu Cys Ser Phe Pro Leu Asn Ala His Met Asn Ala           
65                  70                  75                  80            

acc aac cac gct ata gtt cag act ctg gtt cat ctg atg ttt cct gac        288
Thr Asn His Ala Ile Val Gln Thr Leu Val His Leu Met Phe Pro Asp           
                85                  90                  95                

cac gta cca aag cct tgt tgt gct cca acc aaa tta aat gcc atc tct        336
His Val Pro Lys Pro Cys Cys Ala Pro Thr Lys Leu Asn Ala Ile Ser           
            100                 105                 110                   

gtt ctg tac ttt gat gac agc tcc aat gtc att ttg aaa aaa tat aga        384
Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg           
        115                 120                 125                       

aat atg gta gta cgc tca tgt ggc tgc cac                                414
Asn Met Val Val Arg Ser Cys Gly Cys His                                   
    130                 135                                               


<210>  47
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  47

Ala Ala Asn Lys Arg Lys Asn Gln Asn Arg Asn Lys Ser Ser Ser His 
1               5                   10                  15      


Gln Asp Ser Ser Arg Met Ser Ser Val Gly Asp Tyr Asn Thr Ser Glu 
            20                  25                  30          


Gln Lys Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg Asp 
        35                  40                  45              


Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Phe 
    50                  55                  60                  


Tyr Cys Asp Gly Glu Cys Ser Phe Pro Leu Asn Ala His Met Asn Ala 
65                  70                  75                  80  


Thr Asn His Ala Ile Val Gln Thr Leu Val His Leu Met Phe Pro Asp 
                85                  90                  95      


His Val Pro Lys Pro Cys Cys Ala Pro Thr Lys Leu Asn Ala Ile Ser 
            100                 105                 110         


Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg 
        115                 120                 125             


Asn Met Val Val Arg Ser Cys Gly Cys His 
    130                 135             


<210>  48
<211>  396
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(396)

<400>  48
caa cag agt cgt aat cgc tct acc cag tcc cag gac gtg gcg cgg gtc         48
Gln Gln Ser Arg Asn Arg Ser Thr Gln Ser Gln Asp Val Ala Arg Val           
1               5                   10                  15                

tcc agt gct tca gat tac aac agc agt gaa ttg aaa aca gcc tgc agg         96
Ser Ser Ala Ser Asp Tyr Asn Ser Ser Glu Leu Lys Thr Ala Cys Arg           
            20                  25                  30                    

aag cat gag ctg tat gtg agt ttc caa gac ctg gga tgg cag gac tgg        144
Lys His Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp           
        35                  40                  45                        

atc att gca ccc aag ggc tat gct gcc aat tac tgt gat gga gaa tgc        192
Ile Ile Ala Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys           
    50                  55                  60                            

tcc ttc cca ctc aac gca cac atg aat gca acc aac cac gcg att gtg        240
Ser Phe Pro Leu Asn Ala His Met Asn Ala Thr Asn His Ala Ile Val           
65                  70                  75                  80            

cag acc ttg gtt cac ctt atg aac ccc gag tat gtc ccc aaa ccg tgc        288
Gln Thr Leu Val His Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys           
                85                  90                  95                

tgt gcg cca act aag cta aat gcc atc tcg gtt ctt tac ttt gat gac        336
Cys Ala Pro Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp           
            100                 105                 110                   

aac tcc aat gtc att ctg aaa aaa tac agg aat atg gtt gta aga gct        384
Asn Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala           
        115                 120                 125                       

tgt gga tgc cac                                                        396
Cys Gly Cys His                                                           
    130                                                                   


<210>  49
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Gln Ser Arg Asn Arg Ser Thr Gln Ser Gln Asp Val Ala Arg Val 
1               5                   10                  15      


Ser Ser Ala Ser Asp Tyr Asn Ser Ser Glu Leu Lys Thr Ala Cys Arg 
            20                  25                  30          


Lys His Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp 
        35                  40                  45              


Ile Ile Ala Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys 
    50                  55                  60                  


Ser Phe Pro Leu Asn Ala His Met Asn Ala Thr Asn His Ala Ile Val 
65                  70                  75                  80  


Gln Thr Leu Val His Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys 
                85                  90                  95      


Cys Ala Pro Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp 
            100                 105                 110         


Asn Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala 
        115                 120                 125             


Cys Gly Cys His 
    130         


<210>  50
<211>  417
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(417)

<400>  50
tcc acg ggg agc aaa cag cgc agc cag aac cgc tcc aag acg ccc aag         48
Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser Lys Thr Pro Lys           
1               5                   10                  15                

aac cag gaa gcc ctg cgg atg gcc aac gtg gca gag aac agc agc agc         96
Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu Asn Ser Ser Ser           
            20                  25                  30                    

gac cag agg cag gcc tgt aag aag cac gag ctg tat gtc agc ttc cga        144
Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg           
        35                  40                  45                        

gac ctg ggc tgg cag gac tgg atc atc gcg cct gaa ggc tac gcc gcc        192
Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala           
    50                  55                  60                            

tac tac tgt gag ggg gag tgt gcc ttc cct ctg aac tcc tac atg aac        240
Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn Ser Tyr Met Asn           
65                  70                  75                  80            

gcc acc aac cac gcc atc gtg cag acg ctg gtc cac ttc atc aac ccg        288
Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Phe Ile Asn Pro           
                85                  90                  95                

gaa acg gtg ccc aag ccc tgc tgt gcg ccc acg cag ctc aat gcc atc        336
Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln Leu Asn Ala Ile           
            100                 105                 110                   

tcc gtc ctc tac ttc gat gac agc tcc aac gtc atc ctg aag aaa tac        384
Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr           
        115                 120                 125                       

aga aac atg gtg gtc cgg gcc tgt ggc tgc cac                            417
Arg Asn Met Val Val Arg Ala Cys Gly Cys His                               
    130                 135                                               


<210>  51
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  51

Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser Lys Thr Pro Lys 
1               5                   10                  15      


Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu Asn Ser Ser Ser 
            20                  25                  30          


Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg 
        35                  40                  45              


Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala 
    50                  55                  60                  


Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn Ser Tyr Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Phe Ile Asn Pro 
                85                  90                  95      


Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln Leu Asn Ala Ile 
            100                 105                 110         


Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr 
        115                 120                 125             


Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
    130                 135                 


<210>  52
<211>  417
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(417)

<400>  52
gca gtg agg cca ctg agg agg agg cag ccg aag aaa agc aac gag ctg         48
Ala Val Arg Pro Leu Arg Arg Arg Gln Pro Lys Lys Ser Asn Glu Leu           
1               5                   10                  15                

ccg cag gcc aac cga ctc cca ggg atc ttt gat gac gtc cac ggc tcc         96
Pro Gln Ala Asn Arg Leu Pro Gly Ile Phe Asp Asp Val His Gly Ser           
            20                  25                  30                    

cac ggc cgg cag gtc tgc cgt cgg cac gag ctc tac gtc agc ttc cag        144
His Gly Arg Gln Val Cys Arg Arg His Glu Leu Tyr Val Ser Phe Gln           
        35                  40                  45                        

gac ctc ggc tgg ctg gac tgg gtc atc gct ccc caa ggc tac tcg gcc        192
Asp Leu Gly Trp Leu Asp Trp Val Ile Ala Pro Gln Gly Tyr Ser Ala           
    50                  55                  60                            

tat tac tgt gag ggg gag tgc tcc ttc cca ctg gac tcc tgc atg aat        240
Tyr Tyr Cys Glu Gly Glu Cys Ser Phe Pro Leu Asp Ser Cys Met Asn           
65                  70                  75                  80            

gcc acc aac cac gcc atc ctg cag tcc ctg gtg cac ctg atg atg cca        288
Ala Thr Asn His Ala Ile Leu Gln Ser Leu Val His Leu Met Met Pro           
                85                  90                  95                

gac gca gtc ccc aag gcg tgc tgt gca ccc acc aag ctg agc gcc acc        336
Asp Ala Val Pro Lys Ala Cys Cys Ala Pro Thr Lys Leu Ser Ala Thr           
            100                 105                 110                   

tct gtg ctc tac tat gac agc agc aac aat gtc atc ctg cgc aag cac        384
Ser Val Leu Tyr Tyr Asp Ser Ser Asn Asn Val Ile Leu Arg Lys His           
        115                 120                 125                       

cgc aac atg gtg gtc aag gcc tgc ggc tgc cac                            417
Arg Asn Met Val Val Lys Ala Cys Gly Cys His                               
    130                 135                                               


<210>  53
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Val Arg Pro Leu Arg Arg Arg Gln Pro Lys Lys Ser Asn Glu Leu 
1               5                   10                  15      


Pro Gln Ala Asn Arg Leu Pro Gly Ile Phe Asp Asp Val His Gly Ser 
            20                  25                  30          


His Gly Arg Gln Val Cys Arg Arg His Glu Leu Tyr Val Ser Phe Gln 
        35                  40                  45              


Asp Leu Gly Trp Leu Asp Trp Val Ile Ala Pro Gln Gly Tyr Ser Ala 
    50                  55                  60                  


Tyr Tyr Cys Glu Gly Glu Cys Ser Phe Pro Leu Asp Ser Cys Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Leu Gln Ser Leu Val His Leu Met Met Pro 
                85                  90                  95      


Asp Ala Val Pro Lys Ala Cys Cys Ala Pro Thr Lys Leu Ser Ala Thr 
            100                 105                 110         


Ser Val Leu Tyr Tyr Asp Ser Ser Asn Asn Val Ile Leu Arg Lys His 
        115                 120                 125             


Arg Asn Met Val Val Lys Ala Cys Gly Cys His 
    130                 135                 


<210>  54
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)

<400>  54
agc gcc ggg gct ggc agc cac tgt caa aag acc tcc ctg cgg gta aac         48
Ser Ala Gly Ala Gly Ser His Cys Gln Lys Thr Ser Leu Arg Val Asn           
1               5                   10                  15                

ttc gag gac atc ggc tgg gac agc tgg atc att gca ccc aag gag tat         96
Phe Glu Asp Ile Gly Trp Asp Ser Trp Ile Ile Ala Pro Lys Glu Tyr           
            20                  25                  30                    

gaa gcc tac gag tgt aag ggc ggc tgc ttc ttc ccc ttg gct gac gat        144
Glu Ala Tyr Glu Cys Lys Gly Gly Cys Phe Phe Pro Leu Ala Asp Asp           
        35                  40                  45                        

gtg acg ccg acg aaa cac gct atc gtg cag acc ctg gtg cat ctc aag        192
Val Thr Pro Thr Lys His Ala Ile Val Gln Thr Leu Val His Leu Lys           
    50                  55                  60                            

ttc ccc aca aag gtg ggc aag gcc tgc tgt gtg ccc acc aaa ctg agc        240
Phe Pro Thr Lys Val Gly Lys Ala Cys Cys Val Pro Thr Lys Leu Ser           
65                  70                  75                  80            

ccc atc tcc gtc ctc tac aag gat gac atg ggg gtg ccc acc ctc aag        288
Pro Ile Ser Val Leu Tyr Lys Asp Asp Met Gly Val Pro Thr Leu Lys           
                85                  90                  95                

tac cat tac gag ggc atg agc gtg gca gag tgt ggg tgc agg tag            333
Tyr His Tyr Glu Gly Met Ser Val Ala Glu Cys Gly Cys Arg                   
            100                 105                 110                   


<210>  55
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  55

Ser Ala Gly Ala Gly Ser His Cys Gln Lys Thr Ser Leu Arg Val Asn 
1               5                   10                  15      


Phe Glu Asp Ile Gly Trp Asp Ser Trp Ile Ile Ala Pro Lys Glu Tyr 
            20                  25                  30          


Glu Ala Tyr Glu Cys Lys Gly Gly Cys Phe Phe Pro Leu Ala Asp Asp 
        35                  40                  45              


Val Thr Pro Thr Lys His Ala Ile Val Gln Thr Leu Val His Leu Lys 
    50                  55                  60                  


Phe Pro Thr Lys Val Gly Lys Ala Cys Cys Val Pro Thr Lys Leu Ser 
65                  70                  75                  80  


Pro Ile Ser Val Leu Tyr Lys Asp Asp Met Gly Val Pro Thr Leu Lys 
                85                  90                  95      


Tyr His Tyr Glu Gly Met Ser Val Ala Glu Cys Gly Cys Arg 
            100                 105                 110 


<210>  56
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)

<400>  56
aac gcc aaa gga aac tac tgt aag agg acc ccg ctc tac atc gac ttc         48
Asn Ala Lys Gly Asn Tyr Cys Lys Arg Thr Pro Leu Tyr Ile Asp Phe           
1               5                   10                  15                

aag gag att ggg tgg gac tcc tgg atc atc gct ccg cct gga tac gaa         96
Lys Glu Ile Gly Trp Asp Ser Trp Ile Ile Ala Pro Pro Gly Tyr Glu           
            20                  25                  30                    

gcc tat gaa tgc cgt ggt gtt tgt aac tac ccc ctg gca gag cat ctc        144
Ala Tyr Glu Cys Arg Gly Val Cys Asn Tyr Pro Leu Ala Glu His Leu           
        35                  40                  45                        

aca ccc aca aag cat gca att atc cag gcc ttg gtc cac ctc aag aat        192
Thr Pro Thr Lys His Ala Ile Ile Gln Ala Leu Val His Leu Lys Asn           
    50                  55                  60                            

tcc cag aaa gct tcc aaa gcc tgc tgt gtg ccc aca aag cta gag ccc        240
Ser Gln Lys Ala Ser Lys Ala Cys Cys Val Pro Thr Lys Leu Glu Pro           
65                  70                  75                  80            

atc tcc atc ctc tat tta gac aaa ggc gtc gtc acc tac aag ttt aaa        288
Ile Ser Ile Leu Tyr Leu Asp Lys Gly Val Val Thr Tyr Lys Phe Lys           
                85                  90                  95                

tac gaa ggc atg gcc gtc tcc gaa tgt ggc tgt aga                        324
Tyr Glu Gly Met Ala Val Ser Glu Cys Gly Cys Arg                           
            100                 105                                       


<210>  57
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  57

Asn Ala Lys Gly Asn Tyr Cys Lys Arg Thr Pro Leu Tyr Ile Asp Phe 
1               5                   10                  15      


Lys Glu Ile Gly Trp Asp Ser Trp Ile Ile Ala Pro Pro Gly Tyr Glu 
            20                  25                  30          


Ala Tyr Glu Cys Arg Gly Val Cys Asn Tyr Pro Leu Ala Glu His Leu 
        35                  40                  45              


Thr Pro Thr Lys His Ala Ile Ile Gln Ala Leu Val His Leu Lys Asn 
    50                  55                  60                  


Ser Gln Lys Ala Ser Lys Ala Cys Cys Val Pro Thr Lys Leu Glu Pro 
65                  70                  75                  80  


Ile Ser Ile Leu Tyr Leu Asp Lys Gly Val Val Thr Tyr Lys Phe Lys 
                85                  90                  95      


Tyr Glu Gly Met Ala Val Ser Glu Cys Gly Cys Arg 
            100                 105             


<210>  58
<211>  375
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)

<400>  58
caa gca gat ggt atc tca gct gag gtt act gcc tct tcc tca aaa cat         48
Gln Ala Asp Gly Ile Ser Ala Glu Val Thr Ala Ser Ser Ser Lys His           
1               5                   10                  15                

agc ggg cct gaa aat aac cag tgt tcc ctc cac cct ttc caa atc agc         96
Ser Gly Pro Glu Asn Asn Gln Cys Ser Leu His Pro Phe Gln Ile Ser           
            20                  25                  30                    

ttc cgc cag ctg ggt tgg gat cac tgg atc att gct ccc cct ttc tac        144
Phe Arg Gln Leu Gly Trp Asp His Trp Ile Ile Ala Pro Pro Phe Tyr           
        35                  40                  45                        

acc cca aac tac tgt aaa gga act tgt ctc cga gta cta cgc gat ggt        192
Thr Pro Asn Tyr Cys Lys Gly Thr Cys Leu Arg Val Leu Arg Asp Gly           
    50                  55                  60                            

ctc aat tcc ccc aat cac gcc att att cag aac ctt atc aat cag ttg        240
Leu Asn Ser Pro Asn His Ala Ile Ile Gln Asn Leu Ile Asn Gln Leu           
65                  70                  75                  80            

gtg gac cag agt gtc ccc cgg ccc tcc tgt gtc ccg tat aag tat gtt        288
Val Asp Gln Ser Val Pro Arg Pro Ser Cys Val Pro Tyr Lys Tyr Val           
                85                  90                  95                

cca att agt gtc ctt atg att gag gca aat ggg agt att ttg tac aag        336
Pro Ile Ser Val Leu Met Ile Glu Ala Asn Gly Ser Ile Leu Tyr Lys           
            100                 105                 110                   

gag tat gag ggt atg att gct gag tct tgt aca tgc aga                    375
Glu Tyr Glu Gly Met Ile Ala Glu Ser Cys Thr Cys Arg                       
        115                 120                 125                       


<210>  59
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  59

Gln Ala Asp Gly Ile Ser Ala Glu Val Thr Ala Ser Ser Ser Lys His 
1               5                   10                  15      


Ser Gly Pro Glu Asn Asn Gln Cys Ser Leu His Pro Phe Gln Ile Ser 
            20                  25                  30          


Phe Arg Gln Leu Gly Trp Asp His Trp Ile Ile Ala Pro Pro Phe Tyr 
        35                  40                  45              


Thr Pro Asn Tyr Cys Lys Gly Thr Cys Leu Arg Val Leu Arg Asp Gly 
    50                  55                  60                  


Leu Asn Ser Pro Asn His Ala Ile Ile Gln Asn Leu Ile Asn Gln Leu 
65                  70                  75                  80  


Val Asp Gln Ser Val Pro Arg Pro Ser Cys Val Pro Tyr Lys Tyr Val 
                85                  90                  95      


Pro Ile Ser Val Leu Met Ile Glu Ala Asn Gly Ser Ile Leu Tyr Lys 
            100                 105                 110         


Glu Tyr Glu Gly Met Ile Ala Glu Ser Cys Thr Cys Arg 
        115                 120                 125 


<210>  60
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)

<400>  60
gac gcc gaa ccc gtg ttg ggc ggc ggc ccc ggg ggc gct tgt cgc gcg         48
Asp Ala Glu Pro Val Leu Gly Gly Gly Pro Gly Gly Ala Cys Arg Ala           
1               5                   10                  15                

cgg cgg ctg tac gtg agc ttc cgc gag gtg ggc tgg cac cgc tgg gtc         96
Arg Arg Leu Tyr Val Ser Phe Arg Glu Val Gly Trp His Arg Trp Val           
            20                  25                  30                    

atc gcg ccg cgc ggc ttc ctg gcc aac tac tgc cag ggt cag tgc gcg        144
Ile Ala Pro Arg Gly Phe Leu Ala Asn Tyr Cys Gln Gly Gln Cys Ala           
        35                  40                  45                        

ctg ccc gtc gcg ctg tcg ggg tcc ggg ggg ccg ccg gcg ctc aac cac        192
Leu Pro Val Ala Leu Ser Gly Ser Gly Gly Pro Pro Ala Leu Asn His           
    50                  55                  60                            

gct gtg ctg cgc gcg ctc atg cac gcg gcc gcc ccg gga gcc gcc gac        240
Ala Val Leu Arg Ala Leu Met His Ala Ala Ala Pro Gly Ala Ala Asp           
65                  70                  75                  80            

ctg ccc tgc tgc gtg ccc gcg cgc ctg tcg ccc atc tcc gtg ctc ttc        288
Leu Pro Cys Cys Val Pro Ala Arg Leu Ser Pro Ile Ser Val Leu Phe           
                85                  90                  95                

ttt gac aac agc gac aac gtg gtg ctg cgg cag tat gag gac atg gtg        336
Phe Asp Asn Ser Asp Asn Val Val Leu Arg Gln Tyr Glu Asp Met Val           
            100                 105                 110                   

gtg gac gag tgc ggc tgc cgc                                            357
Val Asp Glu Cys Gly Cys Arg                                               
        115                                                               


<210>  61
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  61

Asp Ala Glu Pro Val Leu Gly Gly Gly Pro Gly Gly Ala Cys Arg Ala 
1               5                   10                  15      


Arg Arg Leu Tyr Val Ser Phe Arg Glu Val Gly Trp His Arg Trp Val 
            20                  25                  30          


Ile Ala Pro Arg Gly Phe Leu Ala Asn Tyr Cys Gln Gly Gln Cys Ala 
        35                  40                  45              


Leu Pro Val Ala Leu Ser Gly Ser Gly Gly Pro Pro Ala Leu Asn His 
    50                  55                  60                  


Ala Val Leu Arg Ala Leu Met His Ala Ala Ala Pro Gly Ala Ala Asp 
65                  70                  75                  80  


Leu Pro Cys Cys Val Pro Ala Arg Leu Ser Pro Ile Ser Val Leu Phe 
                85                  90                  95      


Phe Asp Asn Ser Asp Asn Val Val Leu Arg Gln Tyr Glu Asp Met Val 
            100                 105                 110         


Val Asp Glu Cys Gly Cys Arg 
        115                 


<210>  62
<211>  342
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(342)

<400>  62
gca gcc atc cct gtc ccc aag ctt tct tgt aag aac ctc tgc cac cgt         48
Ala Ala Ile Pro Val Pro Lys Leu Ser Cys Lys Asn Leu Cys His Arg           
1               5                   10                  15                

cac cag cta ttc att aac ttc cgg gac ctg ggt tgg cac aag tgg atc         96
His Gln Leu Phe Ile Asn Phe Arg Asp Leu Gly Trp His Lys Trp Ile           
            20                  25                  30                    

att gcc ccc aag ggg ttc atg gca aat tac tgc cat gga gag tgt ccc        144
Ile Ala Pro Lys Gly Phe Met Ala Asn Tyr Cys His Gly Glu Cys Pro           
        35                  40                  45                        

ttc tca ctg acc atc tct ctc aac agc tcc aat tat gct ttc atg caa        192
Phe Ser Leu Thr Ile Ser Leu Asn Ser Ser Asn Tyr Ala Phe Met Gln           
    50                  55                  60                            

gcc ctg atg cat gcc gtt gac cca gag atc ccc cag gct gtg tgt atc        240
Ala Leu Met His Ala Val Asp Pro Glu Ile Pro Gln Ala Val Cys Ile           
65                  70                  75                  80            

ccc acc aag ctg tct ccc att tcc atg ctc tac cag gac aat aat gac        288
Pro Thr Lys Leu Ser Pro Ile Ser Met Leu Tyr Gln Asp Asn Asn Asp           
                85                  90                  95                

aat gtc att cta cga cat tat gaa gac atg gta gtc gat gaa tgt ggg        336
Asn Val Ile Leu Arg His Tyr Glu Asp Met Val Val Asp Glu Cys Gly           
            100                 105                 110                   

tgt ggg                                                                342
Cys Gly                                                                   
                                                                          


<210>  63
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  63

Ala Ala Ile Pro Val Pro Lys Leu Ser Cys Lys Asn Leu Cys His Arg 
1               5                   10                  15      


His Gln Leu Phe Ile Asn Phe Arg Asp Leu Gly Trp His Lys Trp Ile 
            20                  25                  30          


Ile Ala Pro Lys Gly Phe Met Ala Asn Tyr Cys His Gly Glu Cys Pro 
        35                  40                  45              


Phe Ser Leu Thr Ile Ser Leu Asn Ser Ser Asn Tyr Ala Phe Met Gln 
    50                  55                  60                  


Ala Leu Met His Ala Val Asp Pro Glu Ile Pro Gln Ala Val Cys Ile 
65                  70                  75                  80  


Pro Thr Lys Leu Ser Pro Ile Ser Met Leu Tyr Gln Asp Asn Asn Asp 
                85                  90                  95      


Asn Val Ile Leu Arg His Tyr Glu Asp Met Val Val Asp Glu Cys Gly 
            100                 105                 110         


Cys Gly 
        


<210>  64
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)

<400>  64
gcc cca ctg gcc act cgc cag ggc aag cga ccc agc aag aac ctt aag         48
Ala Pro Leu Ala Thr Arg Gln Gly Lys Arg Pro Ser Lys Asn Leu Lys           
1               5                   10                  15                

gct cgc tgc agt cgg aag gca ctg cat gtc aac ttc aag gac atg ggc         96
Ala Arg Cys Ser Arg Lys Ala Leu His Val Asn Phe Lys Asp Met Gly           
            20                  25                  30                    

tgg gac gac tgg atc atc gca ccc ctt gag tac gag gct ttc cac tgc        144
Trp Asp Asp Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Phe His Cys           
        35                  40                  45                        

gag ggg ctg tgc gag ttc cca ttg cgc tcc cac ctg gag ccc acg aat        192
Glu Gly Leu Cys Glu Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn           
    50                  55                  60                            

cat gca gtc atc cag acc ctg atg aac tcc atg gac ccc gag tcc aca        240
His Ala Val Ile Gln Thr Leu Met Asn Ser Met Asp Pro Glu Ser Thr           
65                  70                  75                  80            

cca ccc acc tgc tgt gtg ccc acg cgg ctg agt ccc atc agc atc ctc        288
Pro Pro Thr Cys Cys Val Pro Thr Arg Leu Ser Pro Ile Ser Ile Leu           
                85                  90                  95                

ttc att gac tct gcc aac aac gtg gtg tat aag cag tat gag gac atg        336
Phe Ile Asp Ser Ala Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met           
            100                 105                 110                   

gtc gtg gag tcg tgt ggc tgc agg                                        360
Val Val Glu Ser Cys Gly Cys Arg                                           
        115                 120                                           


<210>  65
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  65

Ala Pro Leu Ala Thr Arg Gln Gly Lys Arg Pro Ser Lys Asn Leu Lys 
1               5                   10                  15      


Ala Arg Cys Ser Arg Lys Ala Leu His Val Asn Phe Lys Asp Met Gly 
            20                  25                  30          


Trp Asp Asp Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Phe His Cys 
        35                  40                  45              


Glu Gly Leu Cys Glu Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn 
    50                  55                  60                  


His Ala Val Ile Gln Thr Leu Met Asn Ser Met Asp Pro Glu Ser Thr 
65                  70                  75                  80  


Pro Pro Thr Cys Cys Val Pro Thr Arg Leu Ser Pro Ile Ser Ile Leu 
                85                  90                  95      


Phe Ile Asp Ser Ala Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met 
            100                 105                 110         


Val Val Glu Ser Cys Gly Cys Arg 
        115                 120 


<210>  66
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)

<400>  66
acg gcc ttc gcc agt cgc cat ggc aag cgg cac ggc aag aag tcc agg         48
Thr Ala Phe Ala Ser Arg His Gly Lys Arg His Gly Lys Lys Ser Arg           
1               5                   10                  15                

cta cgc tgc agc aag aag ccc ctg cac gtg aac ttc aag gag ctg ggc         96
Leu Arg Cys Ser Lys Lys Pro Leu His Val Asn Phe Lys Glu Leu Gly           
            20                  25                  30                    

tgg gac gac tgg att atc gcg ccc ctg gag tac gag gcc tat cac tgc        144
Trp Asp Asp Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Tyr His Cys           
        35                  40                  45                        

gag ggt gta tgc gac ttc ccg ctg cgc tcg cac ctg gag ccc acc aac        192
Glu Gly Val Cys Asp Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn           
    50                  55                  60                            

cac gcc atc atc cag acg ctg atg aac tcc atg gac ccc ggc tcc acc        240
His Ala Ile Ile Gln Thr Leu Met Asn Ser Met Asp Pro Gly Ser Thr           
65                  70                  75                  80            

ccg ccc agc tgc tgc gtg ccc acc aaa ttg act ccc atc agc att cta        288
Pro Pro Ser Cys Cys Val Pro Thr Lys Leu Thr Pro Ile Ser Ile Leu           
                85                  90                  95                

tac atc gac gcg ggc aat aat gtg gtc tac aag cag tac gag gac atg        336
Tyr Ile Asp Ala Gly Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met           
            100                 105                 110                   

gtg gtg gag tcg tgc ggc tgc agg                                        360
Val Val Glu Ser Cys Gly Cys Arg                                           
        115                 120                                           


<210>  67
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  67

Thr Ala Phe Ala Ser Arg His Gly Lys Arg His Gly Lys Lys Ser Arg 
1               5                   10                  15      


Leu Arg Cys Ser Lys Lys Pro Leu His Val Asn Phe Lys Glu Leu Gly 
            20                  25                  30          


Trp Asp Asp Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Tyr His Cys 
        35                  40                  45              


Glu Gly Val Cys Asp Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn 
    50                  55                  60                  


His Ala Ile Ile Gln Thr Leu Met Asn Ser Met Asp Pro Gly Ser Thr 
65                  70                  75                  80  


Pro Pro Ser Cys Cys Val Pro Thr Lys Leu Thr Pro Ile Ser Ile Leu 
                85                  90                  95      


Tyr Ile Asp Ala Gly Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met 
            100                 105                 110         


Val Val Glu Ser Cys Gly Cys Arg 
        115                 120 


<210>  68
<211>  387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(387)

<400>  68
acg gcg ttg gcc ggg acg cgg aca tcg cag ggc agc ggc ggg ggc gcg         48
Thr Ala Leu Ala Gly Thr Arg Thr Ser Gln Gly Ser Gly Gly Gly Ala           
1               5                   10                  15                

ggc cgg ggc cac ggg cgc agg ggc cgg agc cgc tgc agc cgc aag ccg         96
Gly Arg Gly His Gly Arg Arg Gly Arg Ser Arg Cys Ser Arg Lys Pro           
            20                  25                  30                    

ttg cac gtg gac ttc aag gag ctc ggc tgg gac gac tgg atc atc gcg        144
Leu His Val Asp Phe Lys Glu Leu Gly Trp Asp Asp Trp Ile Ile Ala           
        35                  40                  45                        

ccg ctg gac tac gag gcg tac cac tgc gag ggc ctt tgc gac ttc cct        192
Pro Leu Asp Tyr Glu Ala Tyr His Cys Glu Gly Leu Cys Asp Phe Pro           
    50                  55                  60                            

ttg cgt tcg cac ctc gag ccc acc aac cat gcc atc att cag acg ctg        240
Leu Arg Ser His Leu Glu Pro Thr Asn His Ala Ile Ile Gln Thr Leu           
65                  70                  75                  80            

ctc aac tcc atg gca cca gac gcg gcg ccg gcc tcc tgc tgt gtg cca        288
Leu Asn Ser Met Ala Pro Asp Ala Ala Pro Ala Ser Cys Cys Val Pro           
                85                  90                  95                

gcg cgc ctc agc ccc atc agc atc ctc tac atc gac gcc gcc aac aac        336
Ala Arg Leu Ser Pro Ile Ser Ile Leu Tyr Ile Asp Ala Ala Asn Asn           
            100                 105                 110                   

gtt gtc tac aag caa tac gag gac atg gtg gtg gag gcc tgc ggc tgc        384
Val Val Tyr Lys Gln Tyr Glu Asp Met Val Val Glu Ala Cys Gly Cys           
        115                 120                 125                       

agg                                                                    387
Arg                                                                       
                                                                          


<210>  69
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  69

Thr Ala Leu Ala Gly Thr Arg Thr Ser Gln Gly Ser Gly Gly Gly Ala 
1               5                   10                  15      


Gly Arg Gly His Gly Arg Arg Gly Arg Ser Arg Cys Ser Arg Lys Pro 
            20                  25                  30          


Leu His Val Asp Phe Lys Glu Leu Gly Trp Asp Asp Trp Ile Ile Ala 
        35                  40                  45              


Pro Leu Asp Tyr Glu Ala Tyr His Cys Glu Gly Leu Cys Asp Phe Pro 
    50                  55                  60                  


Leu Arg Ser His Leu Glu Pro Thr Asn His Ala Ile Ile Gln Thr Leu 
65                  70                  75                  80  


Leu Asn Ser Met Ala Pro Asp Ala Ala Pro Ala Ser Cys Cys Val Pro 
                85                  90                  95      


Ala Arg Leu Ser Pro Ile Ser Ile Leu Tyr Ile Asp Ala Ala Asn Asn 
            100                 105                 110         


Val Val Tyr Lys Gln Tyr Glu Asp Met Val Val Glu Ala Cys Gly Cys 
        115                 120                 125             


Arg 
    


<210>  70
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)

<400>  70
gat ttt ggt ctt gac tgt gat gag cac tca aca gaa tca cga tgc tgt         48
Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys Cys           
1               5                   10                  15                

cgt tac cct cta act gtg gat ttt gaa gct ttt gga tgg gat tgg att         96
Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile           
            20                  25                  30                    

atc gct cct aaa aga tat aag gcc aat tac tgc tct gga gag tgt gaa        144
Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu           
        35                  40                  45                        

ttt gta ttt tta caa aaa tat cct cat act cat ctg gta cac caa gca        192
Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala           
    50                  55                  60                            

aac ccc aga ggt tca gca ggc cct tgc tgt act ccc aca aag atg tct        240
Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser           
65                  70                  75                  80            

cca att aat atg cta tat ttt aat ggc aaa gaa caa ata ata tat ggg        288
Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly           
                85                  90                  95                

aaa att cca gcg atg gta gta gac cgc tgt ggg tgc tca                    327
Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser                       
            100                 105                                       


<210>  71
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  71

Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys Cys 
1               5                   10                  15      


Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile 
            20                  25                  30          


Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu 
        35                  40                  45              


Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala 
    50                  55                  60                  


Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser 
65                  70                  75                  80  


Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly 
                85                  90                  95      


Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser 
            100                 105                 


<210>  72
<211>  405
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(405)

<400>  72
ggt cag gaa act gtc agt tct gaa ttg aag aag ccc ttg ggc cca gct         48
Gly Gln Glu Thr Val Ser Ser Glu Leu Lys Lys Pro Leu Gly Pro Ala           
1               5                   10                  15                

tcc ttc aat ctg agt gaa tac ttc aga caa ttt ctt ctt ccc caa aat         96
Ser Phe Asn Leu Ser Glu Tyr Phe Arg Gln Phe Leu Leu Pro Gln Asn           
            20                  25                  30                    

gag tgt gag ctc cat gac ttt aga ctt agc ttt agt cag ctg aag tgg        144
Glu Cys Glu Leu His Asp Phe Arg Leu Ser Phe Ser Gln Leu Lys Trp           
        35                  40                  45                        

gac aac tgg att gtg gct ccg cac agg tac aac cct cga tac tgt aaa        192
Asp Asn Trp Ile Val Ala Pro His Arg Tyr Asn Pro Arg Tyr Cys Lys           
    50                  55                  60                            

ggg gac tgt cca agg gca gtt gga cat cgg tat ggc tct cca gtt cac        240
Gly Asp Cys Pro Arg Ala Val Gly His Arg Tyr Gly Ser Pro Val His           
65                  70                  75                  80            

acc atg gta cag aac atc atc tat gag aag ctg gac tcc tca gtg cca        288
Thr Met Val Gln Asn Ile Ile Tyr Glu Lys Leu Asp Ser Ser Val Pro           
                85                  90                  95                

aga ccg tca tgt gta cct gcc aaa tac agc ccc ttg agt gtt ttg acc        336
Arg Pro Ser Cys Val Pro Ala Lys Tyr Ser Pro Leu Ser Val Leu Thr           
            100                 105                 110                   

att gag ccc gat ggc tca att gcc tat aaa gag tac gaa gat atg ata        384
Ile Glu Pro Asp Gly Ser Ile Ala Tyr Lys Glu Tyr Glu Asp Met Ile           
        115                 120                 125                       

gct aca aag tgc acc tgt cgt                                            405
Ala Thr Lys Cys Thr Cys Arg                                               
    130                 135                                               


<210>  73
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  73

Gly Gln Glu Thr Val Ser Ser Glu Leu Lys Lys Pro Leu Gly Pro Ala 
1               5                   10                  15      


Ser Phe Asn Leu Ser Glu Tyr Phe Arg Gln Phe Leu Leu Pro Gln Asn 
            20                  25                  30          


Glu Cys Glu Leu His Asp Phe Arg Leu Ser Phe Ser Gln Leu Lys Trp 
        35                  40                  45              


Asp Asn Trp Ile Val Ala Pro His Arg Tyr Asn Pro Arg Tyr Cys Lys 
    50                  55                  60                  


Gly Asp Cys Pro Arg Ala Val Gly His Arg Tyr Gly Ser Pro Val His 
65                  70                  75                  80  


Thr Met Val Gln Asn Ile Ile Tyr Glu Lys Leu Asp Ser Ser Val Pro 
                85                  90                  95      


Arg Pro Ser Cys Val Pro Ala Lys Tyr Ser Pro Leu Ser Val Leu Thr 
            100                 105                 110         


Ile Glu Pro Asp Gly Ser Ile Ala Tyr Lys Glu Tyr Glu Asp Met Ile 
        115                 120                 125             


Ala Thr Lys Cys Thr Cys Arg 
    130                 135 


<210>  74
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)

<400>  74
aag acg atg cag aaa gcc cgg agg aag cag tgg gat gag ccg agg gtg         48
Lys Thr Met Gln Lys Ala Arg Arg Lys Gln Trp Asp Glu Pro Arg Val           
1               5                   10                  15                

tgc tcc cgg agg tac ctg aag gtg gac ttc gca gac atc ggc tgg aat         96
Cys Ser Arg Arg Tyr Leu Lys Val Asp Phe Ala Asp Ile Gly Trp Asn           
            20                  25                  30                    

gaa tgg ata atc tca ccg aaa tct ttt gat gcc tac tac tgc gcg gga        144
Glu Trp Ile Ile Ser Pro Lys Ser Phe Asp Ala Tyr Tyr Cys Ala Gly           
        35                  40                  45                        

gca tgt gag ttc ccc atg cct aag atc gtt cgt cca tcc aac cat gcc        192
Ala Cys Glu Phe Pro Met Pro Lys Ile Val Arg Pro Ser Asn His Ala           
    50                  55                  60                            

acc atc cag agc att gtc agg gct gtg ggc atc atc cct ggc atc cca        240
Thr Ile Gln Ser Ile Val Arg Ala Val Gly Ile Ile Pro Gly Ile Pro           
65                  70                  75                  80            

gag ccc tgc tgt gtt ccc gat aag atg aac tcc ctt ggg gtc ctc ttc        288
Glu Pro Cys Cys Val Pro Asp Lys Met Asn Ser Leu Gly Val Leu Phe           
                85                  90                  95                

ctg gat gag aat cgg aat gtg gtt ctg aag gtg tac ccc aac atg tcc        336
Leu Asp Glu Asn Arg Asn Val Val Leu Lys Val Tyr Pro Asn Met Ser           
            100                 105                 110                   

gtg gac acc tgt gcc tgc cgg tga                                        360
Val Asp Thr Cys Ala Cys Arg                                               
        115                                                               


<210>  75
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  75

Lys Thr Met Gln Lys Ala Arg Arg Lys Gln Trp Asp Glu Pro Arg Val 
1               5                   10                  15      


Cys Ser Arg Arg Tyr Leu Lys Val Asp Phe Ala Asp Ile Gly Trp Asn 
            20                  25                  30          


Glu Trp Ile Ile Ser Pro Lys Ser Phe Asp Ala Tyr Tyr Cys Ala Gly 
        35                  40                  45              


Ala Cys Glu Phe Pro Met Pro Lys Ile Val Arg Pro Ser Asn His Ala 
    50                  55                  60                  


Thr Ile Gln Ser Ile Val Arg Ala Val Gly Ile Ile Pro Gly Ile Pro 
65                  70                  75                  80  


Glu Pro Cys Cys Val Pro Asp Lys Met Asn Ser Leu Gly Val Leu Phe 
                85                  90                  95      


Leu Asp Glu Asn Arg Asn Val Val Leu Lys Val Tyr Pro Asn Met Ser 
            100                 105                 110         


Val Asp Thr Cys Ala Cys Arg 
        115                 


<210>  76
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)

<400>  76
aac ctg ggt ctg gac tgc gac gag cac tca agc gag tcc cgc tgc tgc         48
Asn Leu Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys           
1               5                   10                  15                

cga tat ccc ctc aca gtg gac ttt gag gct ttc ggc tgg gac tgg atc         96
Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile           
            20                  25                  30                    

atc gca cct aag cgc tac aag gcc aac tac tgc tcc ggc cag tgc gag        144
Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu           
        35                  40                  45                        

tac atg ttc atg caa aaa tat ccg cat acc cat ttg gtg cag cag gcc        192
Tyr Met Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala           
    50                  55                  60                            

aat cca aga ggc tct gct ggg ccc tgt tgt acc ccc acc aag atg tcc        240
Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser           
65                  70                  75                  80            

cca atc aac atg ctc tac ttc aat gac aag cag cag att atc tac ggc        288
Pro Ile Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly           
                85                  90                  95                

aag atc cct ggc atg gtg gtg gat cgc tgt ggc tgc tct                    327
Lys Ile Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser                       
            100                 105                                       


<210>  77
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  77

Asn Leu Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys 
1               5                   10                  15      


Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile 
            20                  25                  30          


Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu 
        35                  40                  45              


Tyr Met Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala 
    50                  55                  60                  


Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser 
65                  70                  75                  80  


Pro Ile Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly 
                85                  90                  95      


Lys Ile Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser 
            100                 105                 


<210>  78
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)

<400>  78
gcg cgc aac ggg gac cac tgt ccg ctc ggg ccc ggg cgt tgc tgc cgt         48
Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg           
1               5                   10                  15                

ctg cac acg gtc cgc gcg tcg ctg gaa gac ctg ggc tgg gcc gat tgg         96
Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp           
            20                  25                  30                    

gtg ctg tcg cca cgg gag gtg caa gtg acc atg tgc atc ggc gcg tgc        144
Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys           
        35                  40                  45                        

ccg agc cag ttc cgg gcg gca aac atg cac gcg cag atc aag acg agc        192
Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser           
    50                  55                  60                            

ctg cac cgc ctg aag ccc gac acg gtg cca gcg ccc tgc tgc gtg ccc        240
Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro           
65                  70                  75                  80            

gcc agc tac aat ccc atg gtg ctc att caa aag acc gac acc ggg gtg        288
Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val           
                85                  90                  95                

tcg ctc cag acc tat gat gac ttg tta gcc aaa gac tgc cac tgc ata        336
Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile           
            100                 105                 110                   


<210>  79
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  80
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)

<400>  80
cat cac ttg cca gac aga agt caa ctg tgt cgg aag gtc aag ttc cag         48
His His Leu Pro Asp Arg Ser Gln Leu Cys Arg Lys Val Lys Phe Gln           
1               5                   10                  15                

gtg gac ttc aac ctg atc gga tgg ggc tcc tgg atc atc tac ccc aag         96
Val Asp Phe Asn Leu Ile Gly Trp Gly Ser Trp Ile Ile Tyr Pro Lys           
            20                  25                  30                    

cag tac aac gcc tat cgc tgt gag ggc gag tgt cct aat cct gtt ggg        144
Gln Tyr Asn Ala Tyr Arg Cys Glu Gly Glu Cys Pro Asn Pro Val Gly           
        35                  40                  45                        

gag gag ttt cat ccg acc aac cat gca tac atc cag agt ctg ctg aaa        192
Glu Glu Phe His Pro Thr Asn His Ala Tyr Ile Gln Ser Leu Leu Lys           
    50                  55                  60                            

cgt tac cag ccc cac cga gtc cct tcc act tgt tgt gcc cca gtg aag        240
Arg Tyr Gln Pro His Arg Val Pro Ser Thr Cys Cys Ala Pro Val Lys           
65                  70                  75                  80            

acc aag ccg ctg agc atg ctg tat gtg gat aat ggc aga gtg ctc cta        288
Thr Lys Pro Leu Ser Met Leu Tyr Val Asp Asn Gly Arg Val Leu Leu           
                85                  90                  95                

gat cac cat aaa gac atg atc gtg gaa gaa tgt ggg tgc ctc                330
Asp His His Lys Asp Met Ile Val Glu Glu Cys Gly Cys Leu                   
            100                 105                 110                   


<210>  81
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  81

His His Leu Pro Asp Arg Ser Gln Leu Cys Arg Lys Val Lys Phe Gln 
1               5                   10                  15      


Val Asp Phe Asn Leu Ile Gly Trp Gly Ser Trp Ile Ile Tyr Pro Lys 
            20                  25                  30          


Gln Tyr Asn Ala Tyr Arg Cys Glu Gly Glu Cys Pro Asn Pro Val Gly 
        35                  40                  45              


Glu Glu Phe His Pro Thr Asn His Ala Tyr Ile Gln Ser Leu Leu Lys 
    50                  55                  60                  


Arg Tyr Gln Pro His Arg Val Pro Ser Thr Cys Cys Ala Pro Val Lys 
65                  70                  75                  80  


Thr Lys Pro Leu Ser Met Leu Tyr Val Asp Asn Gly Arg Val Leu Leu 
                85                  90                  95      


Asp His His Lys Asp Met Ile Val Glu Glu Cys Gly Cys Leu 
            100                 105                 110 


<210>  82
<211>  345
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(345)

<400>  82
ggc ctg gag tgc gac ggc aag gtc aac atc tgc tgt aag aaa cag ttc         48
Gly Leu Glu Cys Asp Gly Lys Val Asn Ile Cys Cys Lys Lys Gln Phe           
1               5                   10                  15                

ttt gtc agt ttc aag gac atc ggc tgg aat gac tgg atc att gct ccc         96
Phe Val Ser Phe Lys Asp Ile Gly Trp Asn Asp Trp Ile Ile Ala Pro           
            20                  25                  30                    

tct ggc tat cat gcc aac tac tgc gag ggt gag tgc ccg agc cat ata        144
Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys Pro Ser His Ile           
        35                  40                  45                        

gca ggc acg tcc ggg tcc tca ctg tcc ttc cac tca aca gtc atc aac        192
Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser Thr Val Ile Asn           
    50                  55                  60                            

cac tac gca tgc ggc cat agc ccc ttt gcc aac ctc aaa tcg tgc tgt        240
His Tyr Ala Cys Gly His Ser Pro Phe Ala Asn Leu Lys Ser Cys Cys           
65                  70                  75                  80            

gtg ccc acc aag ctg aga ccc atg tcc atg ttg tac tat gat gat ggt        288
Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr Tyr Asp Asp Gly           
                85                  90                  95                

caa aac atc atc aaa aag gac att cag aac atg atc gtg gag gag tgc        336
Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu Cys           
            100                 105                 110                   

ggg tgc tcc                                                            345
Gly Cys Ser                                                               
        115                                                               


<210>  83
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  83

Gly Leu Glu Cys Asp Gly Lys Val Asn Ile Cys Cys Lys Lys Gln Phe 
1               5                   10                  15      


Phe Val Ser Phe Lys Asp Ile Gly Trp Asn Asp Trp Ile Ile Ala Pro 
            20                  25                  30          


Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys Pro Ser His Ile 
        35                  40                  45              


Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser Thr Val Ile Asn 
    50                  55                  60                  


His Tyr Ala Cys Gly His Ser Pro Phe Ala Asn Leu Lys Ser Cys Cys 
65                  70                  75                  80  


Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr Tyr Asp Asp Gly 
                85                  90                  95      


Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu Cys 
            100                 105                 110         


Gly Cys Ser 
        115 


<210>  84
<211>  345
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(345)

<400>  84
ggc ctg gag tgc gat ggc cgg acc aac ctc tgt tgc agg caa cag ttc         48
Gly Leu Glu Cys Asp Gly Arg Thr Asn Leu Cys Cys Arg Gln Gln Phe           
1               5                   10                  15                

ttc att gac ttc cgc ctc atc ggc tgg aac gac tgg atc ata gca ccc         96
Phe Ile Asp Phe Arg Leu Ile Gly Trp Asn Asp Trp Ile Ile Ala Pro           
            20                  25                  30                    

acc ggc tac tac ggc aac tac tgt gag ggc agc tgc cca gcc tac ctg        144
Thr Gly Tyr Tyr Gly Asn Tyr Cys Glu Gly Ser Cys Pro Ala Tyr Leu           
        35                  40                  45                        

gca ggg gtc ccc ggc tct gcc tcc tcc ttc cac acg gct gtg gtg aac        192
Ala Gly Val Pro Gly Ser Ala Ser Ser Phe His Thr Ala Val Val Asn           
    50                  55                  60                            

cag tac cgc atg cgg ggt ctg aac ccc ggc acg gtg aac tcc tgc tgc        240
Gln Tyr Arg Met Arg Gly Leu Asn Pro Gly Thr Val Asn Ser Cys Cys           
65                  70                  75                  80            

att ccc acc aag ctg agc acc atg tcc atg ctg tac ttc gat gat gag        288
Ile Pro Thr Lys Leu Ser Thr Met Ser Met Leu Tyr Phe Asp Asp Glu           
                85                  90                  95                

tac aac atc gtc aag cgg gac gtg ccc aac atg att gtg gag gag tgc        336
Tyr Asn Ile Val Lys Arg Asp Val Pro Asn Met Ile Val Glu Glu Cys           
            100                 105                 110                   

ggc tgc gcc                                                            345
Gly Cys Ala                                                               
        115                                                               


<210>  85
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  85

Gly Leu Glu Cys Asp Gly Arg Thr Asn Leu Cys Cys Arg Gln Gln Phe 
1               5                   10                  15      


Phe Ile Asp Phe Arg Leu Ile Gly Trp Asn Asp Trp Ile Ile Ala Pro 
            20                  25                  30          


Thr Gly Tyr Tyr Gly Asn Tyr Cys Glu Gly Ser Cys Pro Ala Tyr Leu 
        35                  40                  45              


Ala Gly Val Pro Gly Ser Ala Ser Ser Phe His Thr Ala Val Val Asn 
    50                  55                  60                  


Gln Tyr Arg Met Arg Gly Leu Asn Pro Gly Thr Val Asn Ser Cys Cys 
65                  70                  75                  80  


Ile Pro Thr Lys Leu Ser Thr Met Ser Met Leu Tyr Phe Asp Asp Glu 
                85                  90                  95      


Tyr Asn Ile Val Lys Arg Asp Val Pro Asn Met Ile Val Glu Glu Cys 
            100                 105                 110         


Gly Cys Ala 
        115 


<210>  86
<211>  348
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(348)

<400>  86
ggc atc gac tgc caa gga ggg tcc agg atg tgc tgt cga caa gag ttt         48
Gly Ile Asp Cys Gln Gly Gly Ser Arg Met Cys Cys Arg Gln Glu Phe           
1               5                   10                  15                

ttt gtg gac ttc cgt gag att ggc tgg cac gac tgg atc atc cag cct         96
Phe Val Asp Phe Arg Glu Ile Gly Trp His Asp Trp Ile Ile Gln Pro           
            20                  25                  30                    

gag ggc tac gcc atg aac ttc tgc ata ggg cag tgc cca cta cac ata        144
Glu Gly Tyr Ala Met Asn Phe Cys Ile Gly Gln Cys Pro Leu His Ile           
        35                  40                  45                        

gca ggc atg cct ggt att gct gcc tcc ttt cac act gca gtg ctc aat        192
Ala Gly Met Pro Gly Ile Ala Ala Ser Phe His Thr Ala Val Leu Asn           
    50                  55                  60                            

ctt ctc aag gcc aac aca gct gca ggc acc act gga ggg ggc tca tgc        240
Leu Leu Lys Ala Asn Thr Ala Ala Gly Thr Thr Gly Gly Gly Ser Cys           
65                  70                  75                  80            

tgt gta ccc acg gcc cgg cgc ccc ctg tct ctg ctc tat tat gac agg        288
Cys Val Pro Thr Ala Arg Arg Pro Leu Ser Leu Leu Tyr Tyr Asp Arg           
                85                  90                  95                

gac agc aac att gtc aag act gac ata cct gac atg gta gta gag gcc        336
Asp Ser Asn Ile Val Lys Thr Asp Ile Pro Asp Met Val Val Glu Ala           
            100                 105                 110                   

tgt ggg tgc agt                                                        348
Cys Gly Cys Ser                                                           
        115                                                               


<210>  87
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  87

Gly Ile Asp Cys Gln Gly Gly Ser Arg Met Cys Cys Arg Gln Glu Phe 
1               5                   10                  15      


Phe Val Asp Phe Arg Glu Ile Gly Trp His Asp Trp Ile Ile Gln Pro 
            20                  25                  30          


Glu Gly Tyr Ala Met Asn Phe Cys Ile Gly Gln Cys Pro Leu His Ile 
        35                  40                  45              


Ala Gly Met Pro Gly Ile Ala Ala Ser Phe His Thr Ala Val Leu Asn 
    50                  55                  60                  


Leu Leu Lys Ala Asn Thr Ala Ala Gly Thr Thr Gly Gly Gly Ser Cys 
65                  70                  75                  80  


Cys Val Pro Thr Ala Arg Arg Pro Leu Ser Leu Leu Tyr Tyr Asp Arg 
                85                  90                  95      


Asp Ser Asn Ile Val Lys Thr Asp Ile Pro Asp Met Val Val Glu Ala 
            100                 105                 110         


Cys Gly Cys Ser 
        115     


<210>  88
<211>  342
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(342)

<400>  88
acc ccc acc tgt gag cct gcg acc ccc tta tgt tgc agg cga gac cat         48
Thr Pro Thr Cys Glu Pro Ala Thr Pro Leu Cys Cys Arg Arg Asp His           
1               5                   10                  15                

tac gta gac ttc cag gaa ctg gga tgg cgg gac tgg ata ctg cag ccc         96
Tyr Val Asp Phe Gln Glu Leu Gly Trp Arg Asp Trp Ile Leu Gln Pro           
            20                  25                  30                    

gag ggg tac cag ctg aat tac tgc agt ggg cag tgc cct ccc cac ctg        144
Glu Gly Tyr Gln Leu Asn Tyr Cys Ser Gly Gln Cys Pro Pro His Leu           
        35                  40                  45                        

gct ggc agc cca ggc att gct gcc tct ttc cat tct gcc gtc ttc agc        192
Ala Gly Ser Pro Gly Ile Ala Ala Ser Phe His Ser Ala Val Phe Ser           
    50                  55                  60                            

ctc ctc aaa gcc aac aat cct tgg cct gcc agt acc tcc tgt tgt gtc        240
Leu Leu Lys Ala Asn Asn Pro Trp Pro Ala Ser Thr Ser Cys Cys Val           
65                  70                  75                  80            

cct act gcc cga agg ccc ctc tct ctc ctc tac ctg gat cat aat ggc        288
Pro Thr Ala Arg Arg Pro Leu Ser Leu Leu Tyr Leu Asp His Asn Gly           
                85                  90                  95                

aat gtg gtc aag acg gat gtg cca gat atg gtg gtg gag gcc tgt ggc        336
Asn Val Val Lys Thr Asp Val Pro Asp Met Val Val Glu Ala Cys Gly           
            100                 105                 110                   

tgc agc                                                                342
Cys Ser                                                                   
                                                                          


<210>  89
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  89

Thr Pro Thr Cys Glu Pro Ala Thr Pro Leu Cys Cys Arg Arg Asp His 
1               5                   10                  15      


Tyr Val Asp Phe Gln Glu Leu Gly Trp Arg Asp Trp Ile Leu Gln Pro 
            20                  25                  30          


Glu Gly Tyr Gln Leu Asn Tyr Cys Ser Gly Gln Cys Pro Pro His Leu 
        35                  40                  45              


Ala Gly Ser Pro Gly Ile Ala Ala Ser Phe His Ser Ala Val Phe Ser 
    50                  55                  60                  


Leu Leu Lys Ala Asn Asn Pro Trp Pro Ala Ser Thr Ser Cys Cys Val 
65                  70                  75                  80  


Pro Thr Ala Arg Arg Pro Leu Ser Leu Leu Tyr Leu Asp His Asn Gly 
                85                  90                  95      


Asn Val Val Lys Thr Asp Val Pro Asp Met Val Val Glu Ala Cys Gly 
            100                 105                 110         


Cys Ser 
        


<210>  90
<211>  402
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(402)

<400>  90
tca act ccc ctg atg tcc tgg cct tgg tct ccc tct gct ctg cgc ctg         48
Ser Thr Pro Leu Met Ser Trp Pro Trp Ser Pro Ser Ala Leu Arg Leu           
1               5                   10                  15                

ctg cag agg cct ccg gag gaa ccg gct gcc cat gcc aac tgc cac aga         96
Leu Gln Arg Pro Pro Glu Glu Pro Ala Ala His Ala Asn Cys His Arg           
            20                  25                  30                    

gta gca ctg aac atc tcc ttc cag gag ctg ggc tgg gaa cgg tgg atc        144
Val Ala Leu Asn Ile Ser Phe Gln Glu Leu Gly Trp Glu Arg Trp Ile           
        35                  40                  45                        

gtg tac cct ccc agt ttc atc ttc cac tac tgt cat ggt ggt tgt ggg        192
Val Tyr Pro Pro Ser Phe Ile Phe His Tyr Cys His Gly Gly Cys Gly           
    50                  55                  60                            

ctg cac atc cca cca aac ctg tcc ctt cca gtc cct ggg gct ccc cct        240
Leu His Ile Pro Pro Asn Leu Ser Leu Pro Val Pro Gly Ala Pro Pro           
65                  70                  75                  80            

acc cca gcc cag ccc tac tcc ttg ctg cca ggg gcc cag ccc tgc tgt        288
Thr Pro Ala Gln Pro Tyr Ser Leu Leu Pro Gly Ala Gln Pro Cys Cys           
                85                  90                  95                

gct gct ctc cca ggg acc atg agg ccc cta cat gtc cgc acc acc tcg        336
Ala Ala Leu Pro Gly Thr Met Arg Pro Leu His Val Arg Thr Thr Ser           
            100                 105                 110                   

gat gga ggt tac tct ttc aag tat gag aca gtg ccc aac ctt ctc acg        384
Asp Gly Gly Tyr Ser Phe Lys Tyr Glu Thr Val Pro Asn Leu Leu Thr           
        115                 120                 125                       

cag cac tgt gct tgt atc                                                402
Gln His Cys Ala Cys Ile                                                   
    130                                                                   


<210>  91
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  91

Ser Thr Pro Leu Met Ser Trp Pro Trp Ser Pro Ser Ala Leu Arg Leu 
1               5                   10                  15      


Leu Gln Arg Pro Pro Glu Glu Pro Ala Ala His Ala Asn Cys His Arg 
            20                  25                  30          


Val Ala Leu Asn Ile Ser Phe Gln Glu Leu Gly Trp Glu Arg Trp Ile 
        35                  40                  45              


Val Tyr Pro Pro Ser Phe Ile Phe His Tyr Cys His Gly Gly Cys Gly 
    50                  55                  60                  


Leu His Ile Pro Pro Asn Leu Ser Leu Pro Val Pro Gly Ala Pro Pro 
65                  70                  75                  80  


Thr Pro Ala Gln Pro Tyr Ser Leu Leu Pro Gly Ala Gln Pro Cys Cys 
                85                  90                  95      


Ala Ala Leu Pro Gly Thr Met Arg Pro Leu His Val Arg Thr Thr Ser 
            100                 105                 110         


Asp Gly Gly Tyr Ser Phe Lys Tyr Glu Thr Val Pro Asn Leu Leu Thr 
        115                 120                 125             


Gln His Cys Ala Cys Ile 
    130                 


<210>  92
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)

<400>  92
gcc ctg gac acc aac tat tgc ttc agc tcc acg gag aag aac tgc tgc         48
Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys           
1               5                   10                  15                

gtg cgg cag ctg tac att gac ttc cgc aag gac ctc ggc tgg aag tgg         96
Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp           
            20                  25                  30                    

atc cac gag ccc aag ggc tac cat gcc aac ttc tgc ctc ggg ccc tgc        144
Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys           
        35                  40                  45                        

ccc tac att tgg agc ctg gac acg cag tac agc aag gtc ctg gcc ctg        192
Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu           
    50                  55                  60                            

tac aac cag cat aac ccg ggc gcc tcg gcg gcg ccg tgc tgc gtg ccg        240
Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro           
65                  70                  75                  80            

cag gcg ctg gag ccg ctg ccc atc gtg tac tac gtg ggc cgc aag ccc        288
Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro           
                85                  90                  95                

aag gtg gag cag ctg tcc aac atg atc gtg cgc tcc tgc aag tgc agc        336
Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser           
            100                 105                 110                   


<210>  93
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  93

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  94
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)

<400>  94
gct ttg gat gcg gcc tat tgc ttt aga aat gtg cag gat aat tgc tgc         48
Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys           
1               5                   10                  15                

cta cgt cca ctt tac att gat ttc aag agg gat cta ggg tgg aaa tgg         96
Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp           
            20                  25                  30                    

ata cac gaa ccc aaa ggg tac aat gcc aac ttc tgt gct gga gca tgc        144
Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys           
        35                  40                  45                        

ccg tat tta tgg agt tca gac act cag cac agc agg gtc ctg agc tta        192
Pro Tyr Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu           
    50                  55                  60                            

tat aat acc ata aat cca gaa gca tct gct tct cct tgc tgc gtg tcc        240
Tyr Asn Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser           
65                  70                  75                  80            

caa gat tta gaa cct cta acc att ctc tac tac att ggc aaa aca ccc        288
Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro           
                85                  90                  95                

aag att gaa cag ctt tct aat atg att gta aag tct tgc aaa tgc agc        336
Lys Ile Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser           
            100                 105                 110                   


<210>  95
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  95

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu 
    50                  55                  60                  


Tyr Asn Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro 
                85                  90                  95      


Lys Ile Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  96
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)

<400>  96
gct ttg gac acc aat tac tgc ttc cgc aac ttg gag gag aac tgc tgt         48
Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys           
1               5                   10                  15                

gtg cgc ccc ctc tac att gac ttc cga cag gat ctg ggc tgg aag tgg         96
Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp           
            20                  25                  30                    

gtc cat gaa cct aag ggc tac tat gcc aac ttc tgc tca ggc cct tgc        144
Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys           
        35                  40                  45                        

cca tac ctc cgc agt gca gac aca acc cac agc acg gtg ctg gga ctg        192
Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu           
    50                  55                  60                            

tac aac act ctg aac cct gaa gca tct gcc tcg cct tgc tgc gtg ccc        240
Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro           
65                  70                  75                  80            

cag gac ctg gag ccc ctg acc atc ctg tac tat gtt ggg agg acc ccc        288
Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro           
                85                  90                  95                

aaa gtg gag cag ctc tcc aac atg gtg gtg aag tct tgt aaa tgt agc        336
Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser           
            100                 105                 110                   


<210>  97
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  97

Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                  55                  60                  


Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


