                         SEQUENCE LISTING

<110>  ALEXION PHARMACEUTICALS, INC.

<120>  Antibodies Containing Therapeutic Peptides

<130>  ALXN-146-WO1

<140>
<141>

<150>  61/208,487
<151>  2009-02-24

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mimetic

<400>  1

Ile Glu Gly Pro Thr Leu Arg Gln Trp Leu Ala Ala Arg Ala 
1               5                   10                  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mimetic

<400>  2

Ile Glu Gly Pro Thr Leu Arg Gln Trp Leu Ala Ala Arg Ala Pro 
1               5                   10                  15  


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mimetic

<400>  3

Asp Tyr His Cys Arg Met Gly Pro Leu Thr Trp Val Cys Lys Pro Leu 
1               5                   10                  15      


Gly Gly 
        


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mimetic

<400>  4

Ala Phe Leu Ala Arg Ala Ala 
1               5           


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  5

Ala Arg Ser Leu 
1               


<210>  6
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  6

Pro Ile 
1       


<210>  7
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  7

Asn Pro 
1       


<210>  8
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  8

Leu Val Gly 
1           


<210>  9
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding a recombinant light chain 
       polypeptide


<220>
<221>  CDS
<222>  (1)..(705)

<400>  9
gac atc cag atg acc cag tct cca tcc tcc ctg tcc gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc ctc act tgc cgg gca agt cag ggc gtt aga aat gct         96
Asp Arg Val Thr Leu Thr Cys Arg Ala Ser Gln Gly Val Arg Asn Ala           
            20                  25                  30                    

tta gtc tgg tat cag cag aaa cca gga aaa gcc cct gag cgc ctg atc        144
Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Arg Leu Ile           
        35                  40                  45                        

tac gct gca tcc att ttg caa agt ggg gtc cca tca agg ttc agc ggc        192
Tyr Ala Ala Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gaa ttc act ctc aca atc ggc ggc ctg cag cct        240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Gly Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttc gca act tat tac tgt cta cag cat aat agt tac ccg tgg        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp           
                85                  90                  95                

acg ttc ggc caa ggg acc aag gtg gaa atc aag cga act gtg gct gca        336
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala           
            100                 105                 110                   

cca tct gtc ttc atc ttc ccg cca tcc gat gag cag ttg aaa tct gga        384
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly           
        115                 120                 125                       

act gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc        432
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala           
    130                 135                 140                           

aaa gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag        480
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln           
145                 150                 155                 160           

gag agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc        528
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser           
                165                 170                 175               

agc acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac        576
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr           
            180                 185                 190                   

gcc tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc        624
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser           
        195                 200                 205                       

ttc aac agg gga gag tgt gcg aga tca ctg att gaa ggg ccg acg ctg        672
Phe Asn Arg Gly Glu Cys Ala Arg Ser Leu Ile Glu Gly Pro Thr Leu           
    210                 215                 220                           

cgg caa tgg ctg gcg gcg cgc gcg ccc atc taa                            705
Arg Gln Trp Leu Ala Ala Arg Ala Pro Ile                                   
225                 230                                                   


<210>  10
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Arg Ala Ser Gln Gly Val Arg Asn Ala 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Arg Leu Ile 
        35                  40                  45              



Tyr Ala Ala Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Arg Ser Leu Ile Glu Gly Pro Thr Leu 
    210                 215                 220                 


Arg Gln Trp Leu Ala Ala Arg Ala Pro Ile 
225                 230                 











<210>  11
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding a recombinant heavy chain 
       polypeptide


<220>
<221>  CDS
<222>  (1)..(1389)

<400>  11
cag gtc cag ctt gtg cag tct ggg gct gag gtg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tcc tgc aag gcc tct gga tac acc ttc act tac tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Tyr           
            20                  25                  30                    

gct atg cat tgg gtg cgc cag gcc ccc gga caa aga cct gag tgg atg        144
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac ggt ggc gat gga aaa aca aaa tat gca cag aag ttc        192
Gly Trp Ile Asn Gly Gly Asp Gly Lys Thr Lys Tyr Ala Gln Lys Phe           
    50                  55                  60                            

cag ggc aga ctc gcc att acc agg gac aca tcc gcg agg acc gcc tac        240
Gln Gly Arg Leu Ala Ile Thr Arg Asp Thr Ser Ala Arg Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg atc agc ctg aca tct gaa gac acg gct gtg tat tac tgt        288
Met Glu Leu Ile Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aaa ggg gcc gag atg acc gtg ggc tcc tgg ggc ccg gga acc ctg        336
Ala Lys Gly Ala Glu Met Thr Val Gly Ser Trp Gly Pro Gly Thr Leu           
            100                 105                 110                   

gtc acc gtc tcc tca gcc tcc acc aag ggc cca tcc gtc ttc ccc ctg        384
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu           
        115                 120                 125                       

gcg ccc tgc tcc agg agc acc tcc gag agc aca gcc gcc ctg ggc tgc        432
Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys           
    130                 135                 140                           

ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca        480
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser           
145                 150                 155                 160           



ggc gcc ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc        528
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser           
                165                 170                 175               

tca gga ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc aac        576
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn           
            180                 185                 190                   

ttc ggc acc cag acc tac acc tgc aac gta gat cac aag ccc agc aac        624
Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn           
        195                 200                 205                       

acc aag gtg gac aag aca gtt gag cgc aaa tgt tgt gtc gag tgc cca        672
Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro           
    210                 215                 220                           

ccg tgc cca gca cca cct gtg gca aat ccg atc gaa ggc cca acc ctg        720
Pro Cys Pro Ala Pro Pro Val Ala Asn Pro Ile Glu Gly Pro Thr Leu           
225                 230                 235                 240           

cgc cag tgg ctg gct gct cgc gct cgt ggg gga ccg tca gtc ttc ctc        768
Arg Gln Trp Leu Ala Ala Arg Ala Arg Gly Gly Pro Ser Val Phe Leu           
                245                 250                 255               

ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag        816
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu           
            260                 265                 270                   

gtc acg tgc gtg gtg gtg gac gtg agc cag gaa gac ccc gag gtc cag        864
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln           
        275                 280                 285                       

ttc aac tgg tac gtg gat ggc gtg gag gtg cat aat gcc aag aca aag        912
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys           
    290                 295                 300                           

ccg cgg gag gag cag ttc aac agc acg tac cgt gtg gtc agc gtc ctc        960
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu           
305                 310                 315                 320           

acc gtc ctg cac cag gac tgg ctg aac ggc aag gag tac aag tgc aag       1008
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys           
                325                 330                 335               

gtc tcc aac aaa ggc ctc ccg tcc tcc atc gag aaa acc atc tcc aaa       1056
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys           
            340                 345                 350                   

gcc aaa ggg cag ccc cga gag cca cag gtg tac acc ctg ccc cca tcc       1104
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser           
        355                 360                 365                       

cag gag gag atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa       1152
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys           
    370                 375                 380                           


ggc ttc tac ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag       1200
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln           
385                 390                 395                 400           

ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc       1248
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly           
                405                 410                 415               

tcc ttc ttc ctc tac agc agg cta acc gtg gac aag agc agg tgg cag       1296
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln           
            420                 425                 430                   

gag ggg aat gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac       1344
Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn           
        435                 440                 445                       

cac tac aca cag aag agc ctc tcc ctg tct ctg ggt aaa tga tga           1389
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys                       
    450                 455                 460                           


<210>  12
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Gly Gly Asp Gly Lys Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Ala Ile Thr Arg Asp Thr Ser Ala Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ile Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Glu Met Thr Val Gly Ser Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
            180                 185                 190         


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Pro Val Ala Asn Pro Ile Glu Gly Pro Thr Leu 
225                 230                 235                 240 


Arg Gln Trp Leu Ala Ala Arg Ala Arg Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460     


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Gln Trp Lys Ser His Lys 
1               5           


<210>  14
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Ala Glu Cys Ser 
1               5   





<210>  15
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Asp Glu Gln Leu Lys Ser 
1               5           


<210>  16
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Asp Tyr Glu Lys His 
1               5       

