                         SEQUENCE LISTING

<110>  Massachusetts Institute of Technology
       Massachusetts General Hospital
       Broad Institute, Inc.
       Haggarty, Stephen
       Fass, Daniel
       Pan, Jennifer
       Ketterman, Josh
       Petryshen, Tracey
       Lewis, Michael
       Holson, Edward
 
<120>  USES OF CHEMICALS TO MODULATE GSK-3 SIGNALING FOR TREATMENT OF 
       BIPOLAR DISORDER AND OTHER BRAIN DISORDERS

<130>  M0656.70175

<140>  not yet assigned
<141>  2010-02-26

<150>  US 61/156,460
<151>  2009-02-27

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2200
<212>  DNA
<213>  Homo sapiens

<400>  1
cccaagccag agcggcgcgg cctggaagag gccagggccc gggggaggcg gcggcagcgg       60

cggcggctgg ggcagcccgg gcagcccgag ccccgcagcc tgggcctgtg ctcggcgcca      120

tgagcggcgg cgggccttcg ggaggcggcc ctgggggctc gggcagggcg cggactagct      180

cgttcgcgga gcccggcggc ggaggcggag gaggcggcgg cggccccgga ggctcggcct      240

ccggcccagg cggcaccggc ggcggaaagg catctgtcgg ggccatgggt gggggcgtcg      300

gggcctcgag ctccgggggt ggacccggcg gcagcggcgg aggaggcagc ggaggccccg      360

gcgcaggcac tagcttcccg ccgcccgggg tgaagctggg ccgtgacagc gggaaggtga      420

ccacagtcgt agccactcta ggccaaggcc cagagcgctc ccaagaagtg gcttacacgg      480

acatcaaagt gattggcaat ggctcatttg gggtcgtgta ccaggcacgg ctggcagaga      540

ccagggaact agtcgccatc aagaaggttc tccaggacaa gaggttcaag aaccgagagc      600

tgcagatcat gcgtaagctg gaccactgca atattgtgag gctgagatac tttttctact      660

ccagtggcga gaagaaagac gagctttacc taaatctggt gctggaatat gtgcccgaga      720

cagtgtaccg ggtggcccgc cacttcacca aggccaagtt gaccatccct atcctctatg      780

tcaaggtgta catgtaccag ctcttccgca gcttggccta catccactcc cagggcgtgt      840

gtcaccgcga catcaagccc cagaacctgc tggtggaccc tgacactgct gtcctcaagc      900

tctgcgattt tggcagtgca aagcagttgg tccgagggga gcccaatgtc tcctacatct      960

gttctcgcta ctaccgggcc ccagagctca tctttggagc cactgattac acctcatcca     1020

tcgatgtttg gtcagctggc tgtgtactgg cagagctcct cttgggccag cccatcttcc     1080

ctggggacag tggggtggac cagctggtgg agatcatcaa ggtgctggga acaccaaccc     1140

gggaacaaat ccgagagatg aaccccaact acacggagtt caagttccct cagattaaag     1200

ctcacccctg gacaaaggtg ttcaaatctc gaacgccgcc agaggccatc gcgctctgct     1260

ctagcctgct ggagtacacc ccatcctcaa ggctctcccc actagaggcc tgtgcgcaca     1320

gcttctttga tgaactgcga tgtctgggaa cccagctgcc taacaaccgc ccacttcccc     1380

ctctcttcaa cttcagtgct ggtgaactct ccatccaacc gtctctcaac gccattctca     1440

tccctcctca cttgaggtcc ccagcgggca ctaccaccct caccccgtcc tcacaagctt     1500

taactgagac tccgaccagc tcagactggc agtcgaccga tgccacacct accctcacta     1560

actcctcctg agggccccac caagcaccct tccacttcca tctgggagcc ccaagagggg     1620

ctgggaaggg gggccatagc ccatcaagct cctgccctgg ctgggcccct agactagagg     1680

gcagaggtaa atgagtccct gtccccacct ccagtccctc cctcaccagc ctcacccctg     1740

tggtgggctt tttaagagga ttttaactgg ttgtggggag ggaagagaag gacagggtgt     1800

tggggggatg aggacctcct acccccttgg ccccctcccc tcccccagac ctccacctcc     1860

tccagacccc ctcccctcct gtgtcccttg taaatagaac cagcccagcc cgtctcctct     1920

tcccttccct ggcccccggg tgtaaataga ttgttataat ttttttctta aagaaaacgt     1980

cgattcgcac cgtccaacct ggccccgccc ctcctacagc tgtaactccc ctcctgtcct     2040

ctgcccccaa ggtctactcc ctcctcaccc caccctggag ggccagggga gtggagagag     2100

ctcctgatgt cttagtttcc acagtaaggt ttgcctgtgt acagacctcc gttcaataaa     2160

ttattggcat gaaaacctga aaaaaaaaaa aaaaaaaaaa                           2200


<210>  2
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Gly Gly Gly Pro Ser Gly Gly Gly Pro Gly Gly Ser Gly Arg 
1               5                   10                  15      


Ala Arg Thr Ser Ser Phe Ala Glu Pro Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Pro Gly Gly Ser Ala Ser Gly Pro Gly Gly Thr Gly Gly 
        35                  40                  45              


Gly Lys Ala Ser Val Gly Ala Met Gly Gly Gly Val Gly Ala Ser Ser 
    50                  55                  60                  


Ser Gly Gly Gly Pro Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Phe Pro Pro Pro Gly Val Lys Leu Gly Arg Asp 
                85                  90                  95      


Ser Gly Lys Val Thr Thr Val Val Ala Thr Leu Gly Gln Gly Pro Glu 
            100                 105                 110         


Arg Ser Gln Glu Val Ala Tyr Thr Asp Ile Lys Val Ile Gly Asn Gly 
        115                 120                 125             


Ser Phe Gly Val Val Tyr Gln Ala Arg Leu Ala Glu Thr Arg Glu Leu 
    130                 135                 140                 


Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg Glu 
145                 150                 155                 160 


Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu Arg 
                165                 170                 175     


Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Leu Tyr Leu Asn 
            180                 185                 190         


Leu Val Leu Glu Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg His 
        195                 200                 205             


Phe Thr Lys Ala Lys Leu Thr Ile Pro Ile Leu Tyr Val Lys Val Tyr 
    210                 215                 220                 


Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Gln Gly Val 
225                 230                 235                 240 


Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Val Asp Pro Asp Thr 
                245                 250                 255     


Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val Arg 
            260                 265                 270         


Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala Pro 
        275                 280                 285             


Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val Trp 
    290                 295                 300                 


Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile Phe 
305                 310                 315                 320 


Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val Leu 
                325                 330                 335     


Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr Thr 
            340                 345                 350         


Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val Phe 
        355                 360                 365             


Lys Ser Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Ser Leu Leu 
    370                 375                 380                 


Glu Tyr Thr Pro Ser Ser Arg Leu Ser Pro Leu Glu Ala Cys Ala His 
385                 390                 395                 400 


Ser Phe Phe Asp Glu Leu Arg Cys Leu Gly Thr Gln Leu Pro Asn Asn 
                405                 410                 415     


Arg Pro Leu Pro Pro Leu Phe Asn Phe Ser Ala Gly Glu Leu Ser Ile 
            420                 425                 430         


Gln Pro Ser Leu Asn Ala Ile Leu Ile Pro Pro His Leu Arg Ser Pro 
        435                 440                 445             


Ala Gly Thr Thr Thr Leu Thr Pro Ser Ser Gln Ala Leu Thr Glu Thr 
    450                 455                 460                 


Pro Thr Ser Ser Asp Trp Gln Ser Thr Asp Ala Thr Pro Thr Leu Thr 
465                 470                 475                 480 


Asn Ser Ser 
            


<210>  3
<211>  1639
<212>  DNA
<213>  Homo sapiens

<400>  3
atcatctata tgttaaatat ccgtgccgat ctgtcttgaa ggagaaatat atcgcttgtt       60

ttgtttttta tagtatacaa aaggagtgaa aagccaagag gacgaagtct ttttcttttt      120

cttctgtggg agaacttaat gctgcattta tcgttaacct aacaccccaa cataaagaca      180

aaaggaagaa aaggaggaag gaaggaaaag gtgattcgcg aagagagtga tcatgtcagg      240

gcggcccaga accacctcct ttgcggagag ctgcaagccg gtgcagcagc cttcagcttt      300

tggcagcatg aaagttagca gagacaagga cggcagcaag gtgacaacag tggtggcaac      360

tcctgggcag ggtccagaca ggccacaaga agtcagctat acagacacta aagtgattgg      420

aaatggatca tttggtgtgg tatatcaagc caaactttgt gattcaggag aactggtcgc      480

catcaagaaa gtattgcagg acaagagatt taagaatcga gagctccaga tcatgagaaa      540

gctagatcac tgtaacatag tccgattgcg ttatttcttc tactccagtg gtgagaagaa      600

agatgaggtc tatcttaatc tggtgctgga ctatgttccg gaaacagtat acagagttgc      660

cagacactat agtcgagcca aacagacgct ccctgtgatt tatgtcaagt tgtatatgta      720

tcagctgttc cgaagtttag cctatatcca ttcctttgga atctgccatc gggatattaa      780

accgcagaac ctcttgttgg atcctgatac tgctgtatta aaactctgtg actttggaag      840

tgcaaagcag ctggtccgag gagaacccaa tgtttcgtat atctgttctc ggtactatag      900

ggcaccagag ttgatctttg gagccactga ttatacctct agtatagatg tatggtctgc      960

tggctgtgtg ttggctgagc tgttactagg acaaccaata tttccagggg atagtggtgt     1020

ggatcagttg gtagaaataa tcaaggtcct gggaactcca acaagggagc aaatcagaga     1080

aatgaaccca aactacacag aatttaaatt ccctcaaatt aaggcacatc cttggactaa     1140

ggattcgtca ggaacaggac atttcacctc aggagtgcgg gtcttccgac cccgaactcc     1200

accggaggca attgcactgt gtagccgtct gctggagtat acaccaactg cccgactaac     1260

accactggaa gcttgtgcac attcattttt tgatgaatta cgggacccaa atgtcaaact     1320

accaaatggg cgagacacac ctgcactctt caacttcacc actcaagaac tgtcaagtaa     1380

tccacctctg gctaccatcc ttattcctcc tcatgctcgg attcaagcag ctgcttcaac     1440

ccccacaaat gccacagcag cgtcagatgc taatactgga gaccgtggac agaccaataa     1500

tgctgcttct gcatcagctt ccaactccac ctgaacagtc ccgagcagcc agctgcacag     1560

gaaaaaccac cagttacttg agtgtcactc agcaacactg gtcacgtttg gaaagaatat     1620

taaaaaaaaa aaaaaaaaa                                                  1639


<210>  4
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Asp 
    290                 295                 300                 


Ser Ser Gly Thr Gly His Phe Thr Ser Gly Val Arg Val Phe Arg Pro 
305                 310                 315                 320 


Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu Leu Glu Tyr 
                325                 330                 335     


Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala His Ser Phe 
            340                 345                 350         


Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn Gly Arg Asp 
        355                 360                 365             


Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser Ser Asn Pro 
    370                 375                 380                 


Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile Gln Ala Ala 
385                 390                 395                 400 


Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala Asn Thr Gly 
                405                 410                 415     


Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala Ser Asn Ser 
            420                 425                 430         


Thr 
    


