                         SEQUENCE LISTING

<110>  Universitt fr Bodenkultur Wien
 
<120>  Biotin-prototrophic yeasts

<130>  BK1/EP

<160>  15    

<170>  PatentIn version 3.3

<210>  1
<211>  3561
<212>  DNA
<213>  artificial

<220>
<223>  pPM2d_ZeoloxP_pTPI

<400>  1
ccggtgaatt cgtgatctga agcttcgtac gctgcaggtc gacaaccctt aatataactt     60

cgtataatgt atgctatacg aagttattag gtctagatcg gtaccacaca ccatagcttc    120

aaaatgtttc tactcctttt ttactcttcc agattttctc ggactccgcg catcgccgta    180

ccacttcaaa acacccaagc acagcatact aaattttccc tctttcttcc tctagggtgt    240

cgttaattac ccgtactaaa ggtttggaaa agaaaaaaga gaccgcctcg tttctttttc    300

ttcgtcgaaa aaggcaataa aaatttttat cacgtttctt tttcttgaaa tttttttttt    360

tagttttttt ctctttcagt gacctccatt gatatttaag ttaataaacg gtcttcaatt    420

tctcaagttt cagtttcatt tttcttgttc tattacaact ttttttactt cttgttcatt    480

agaaagaaag catagcaatc taatctaagg gcggtgttga caattaatca tcggcatagt    540

atatcggcat agtataatac gacaaggtga ggaactaaac catggccaag ttgaccagtg    600

ccgttccggt gctcaccgcg cgcgacgtcg ccggagcggt cgagttctgg accgaccggc    660

tcgggttctc ccgggacttc gtggaggacg acttcgccgg tgtggtccgg gacgacgtga    720

ccctgttcat cagcgcggtc caggaccagg tggtgccgga caacaccctg gcctgggtgt    780

gggtgcgcgg cctggacgag ctgtacgccg agtggtcgga ggtcgtgtcc acgaacttcc    840

gggacgcctc cgggccggcc atgaccgaga tcggcgagca gccgtggggg cgggagttcg    900

ccctgcgcga cccggccggc aactgcgtgc acttcgtggc cgaggagcag gactgacacg    960

tccgacggcg gcccacgggt cccaggcctc ggagatccgt cccccttttc ctttgtcgat   1020

atcatgtaat tagttatgtc acgcttacat tcacgccctc cccccacatc cgctctaacc   1080

gaaaaggaag gagttagaca acctgaagtc taggtcccta tttatttttt tatagttatg   1140

ttagtattaa gaacgttatt tatatttcaa atttttcttt tttttctgta cagacgcgtg   1200

tacgcatgta acattatact gaaaaccttg cttgagaagg ttttgggacg ctcgaaggct   1260

ttaatttgca agctggagac caacatgtga gcaaggtacc attcgagaac ccttaatata   1320

acttcgtata atgtatgcta tacgaagtta ttaggtgata tcagatccac tagatctgaa   1380

ttcgagctct gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg   1440

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag   1500

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc   1560

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg   1620

ggaagcgtgg cgctttctca atgctcacgc tgtaggtatc tcagttcggt gtaggtcgtt   1680

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc   1740

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc   1800

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg   1860

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca   1920

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc   1980

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat   2040

cctttgatct tttctacggg agctcttaat taagcggccg cttaattaag ggcccaagcc   2100

acgccggcgc caaggccctt caacgagaca ctcttccgtc agttccaaaa ccataagttt   2160

gccgatgtgt tggtccttgt aacgcatgga atttgggcca gggtattttt gatgaaatgg   2220

ttcagatggt ctgtggagga gtttgaaggc ttacgaaata taccacattg ccagtttata   2280

cagatggtta agggtgaaaa tcaacgttac accttgacga ccccattatt acgatggcgt   2340

gaaggagatg aagaccgggt agaagaaata agaaaagcgg tacagtttag gtccggagat   2400

ctagggaagg aggccttagc ttatattgta gctgctgaga gagaggcagc tgctggaaga   2460

tctgaaggcc ctatcacgta tgatgatggt gatgaccatt agagaacgcc cagagattga   2520

tagccagttc ttggacaaca attcggaact ttattcacgg tgcaaacatg atttgtgtgg   2580

atagcttcaa gtcagacatt tcatctcatc ccccctttta ctgctgctaa tcaccgttag   2640

tccgacagtt actctaatca atatttatta gtgttttagt tgcgcaaaac tcgagcctct   2700

tttccttatc tcttgacact tcctggagtc gaagtttttc agcgcaaatt cactctacaa   2760

tgtctaccga tactagaccg cctatcttcc ccctctaaat agcctattgg aagggtgcaa   2820

taaggtatat aaatctggcg cgattccccc ggacttttat gatccacatc acctcatctt   2880

actgccctca ctctctttcc tgatcctccc aggtccaccg atttcctcac tatcgtcgga   2940

tttctccttc cagcgcccta gagaattccg taaccaccgc aaaaatagca gcccccccct   3000

cacccatttt tttatttaaa agaacacctt actggcccgt tttcgtttct cctttactac   3060

aattgatttt taattttcag ttttttttca ttgatataca agatctatca caaacacaca   3120

cctgcaggcc atgactagtt ctgcacctta agtctagaga acaaaaactc atctcagaag   3180

aggatctgaa tagcgccgtc gaccatcatc atcatcatca ttgaggccgc ctcggccgga   3240

tccacgtccg acggcggccc acgggtccca ggcctcggag atccgtcccc cttttccttt   3300

gtcgatatca tgtaattagt tatgtcacgc ttacattcac gccctccccc cacatccgct   3360

ctaaccgaaa aggaaggagt tagacaacct gaagtctagg tccctattta tttttttata   3420

gttatgttag tattaagaac gttatttata tttcaaattt ttcttttttt tctgtacaga   3480

cgcgtgtacg catgtaacat tatactgaaa accttgcttg agaaggtttt gggacgctcg   3540

aaggctttaa tttgcaagct a                                             3561


<210>  2
<211>  6705
<212>  DNA
<213>  artificial

<220>
<223>  pPM2d_pPGI_BIO6_pPGK_BIO1 expression vector

<400>  2
ccggtgaatt cgtgatctga agcttcgtac cgagctctga gcaaaaggcc agcaaaaggc     60

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga    120

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata    180

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac    240

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcaat gctcacgctg    300

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc    360

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag    420

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt    480

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt    540

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg    600

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac    660

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacgggag ctcttaatta    720

agcggccgct taattaaggg cccaagccac gccggcgcca aggcccagca ctttctctgg    780

agattagtaa tcgatggtca ggatgggaac cgaatgtctt tggctggcct ttccccaaat    840

ttgagaacaa aattcaattg ctgaggtaat acttttttcc ccatacaaga aaggccatcg    900

tgtaattatc tcttaccttc tactattcga gaagttgtaa ccaaatggct gataacatcg    960

aaaccatccg tcctggaatc aactaccagg acaaactatt gaccgaaata gacattcttg   1020

atgatgttaa acaactgtca acgcagatgg aacaggaagg gaaaggattc gtcttcccta   1080

aagatcatta ctccaagata aaatcactaa aggggttgca agtgaagctg ttgaaagaaa   1140

tgcaagagtt ggctgaaatt cagcagtcta ggcatcaaga cgaaactgca tacaggcaga   1200

agcttcaaga cttggaagat actacatcag aacttagaaa cgttgctttg acgtaatagg   1260

tcacctgtgt tactagatgt cggatgtctg tgattgcagt aacacccggc attcggtcag   1320

ctgtctacct ttcaggatat cctcccccca ccgagctcgg acgcctttct cgcccaccca   1380

ccacgcaaag ttccgcccac cttatacttt gtggaagtct tttcgccgcg caccacactt   1440

gcccgttcgc agaaaaagaa attccaggta gcccttattc cgtcaggcaa taaatatata   1500

agcgattgca gacaatctga cgtcccatcc ccttgtctat ttaaacctcc taggttgctt   1560

aaatttaaaa tctattcgag tcccaacctt tccattcttc cggaataatt caactccaac   1620

caattgataa acacctgcag gatgcttgaa catcaattaa cccaagaaga tctcgaattt   1680

gataaaaaac acatatggca cccgtacaca tcaataacta ctccattgaa agtgtaccct   1740

attaccaaag cagaaggtag ttatttgtac ctcgataatg gtaccaaggt agtagatggt   1800

atggcaagct ggtggtgcgt tcagcaagga tacaacaatc atcgcctaaa tgcagccgcc   1860

atttcacaga ttaataaaat gtcacatgtg atgtttggtg gaattactca taaggctgga   1920

attgattttt gtaaaaagtt gctcgctttg ttaccagata ccctggaatg tgctttactg   1980

gcggattctg ggtctatttc tgtcgacatt gcaatgaaga tggctttaag atatcatcat   2040

tcattgggga atacaacgaa aaaaagattc ttgacaatta agaagggcta ccacggtgac   2100

gcttttggag ccgtatcagt ttgtgaccct gtcaattcaa ggcataatac ttataacggg   2160

tttctcgctg aaaacatatt ctgcaaggct ccagaagtcc gctttgattg tcgtgaaaag   2220

gacgttgaga aactggtaga ggaactcgac gtaaagccat ttgctgagat tattgataaa   2280

caccacagtg aaatttctgg tgttgtgatg gaaagcatcg tacagggcgc tggtggtcta   2340

agaatgtatc atccatattt cctgaaacgt gtccgtgcac tctgcaacga ctttaatatt   2400

ttgttgattc ttgatgaagt tgcagtgggg cttggaagaa cgggtatgct gtttggattt   2460

gagcatgcag ggatagtgcc tgacatagtc tgtctaggta agactttgac ggccggttat   2520

ttgacgttat ctgcaacagt taccaccaga gagattggtg atcagatttc cagtggacct   2580

gagggttgct tcatgcacgg acaaacctat atggcaaatc cgttagcatg cgctgttgca   2640

agtgaaaact tgtcgatctt aatggaaggt aaatggaaat ctcaagttcg gcaaatagaa   2700

gtccagctga agaaagagct ggtgccctta ctggaacacc ccatcgtggc tgatgtaaga   2760

attctagggg ctattggtgt tgtcgaggtt acaaaacgtg tgaacgtcga agtcttacaa   2820

gagaaattta ttaaggcagg tgcgtggatt agacctttcg gtaacataat ctacattcta   2880

cctccataca taattacttc cgaggagttg accgtcttaa cagaagctat cagatctgtt   2940

ctagacttta tttagggccg cctcggccgg atccacgtcc gacggcggcc cacgggtccc   3000

aggcctcgga gatccgtccc ccttttcctt tgtcgatatc atgtaattag ttatgtcacg   3060

cttacattca cgccctcccc ccacatccgc tctaaccgaa aaggaaggag ttagacaacc   3120

tgaagtctag gtccctattt atttttttat agttatgtta gtattaagaa cgttatttat   3180

atttcaaatt tttctttttt ttctgtacag acgcgtgtac gcatgtaaca ttatactgaa   3240

aaccttgctt gagaaggttt tgggacgctc gaaggcttta atttgcaagc taccggcgcc   3300

aaggcccaag ttggtaccca gccgatcacg cctgctctga gtttggctgg agcagcaaat   3360

ctcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt   3420

aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt   3480

gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc   3540

gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg   3600

cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc   3660

gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg   3720

gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctgca   3780

ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga   3840

tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct   3900

ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg   3960

cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca   4020

accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaaca   4080

cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct   4140

tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact   4200

cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa   4260

acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc   4320

atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgataacc   4380

gaggtttaaa ttaaggtaca taacaaaaat tcaatgttca aagacgcaca taccaagact   4440

tactaatcgc agaatgttgg tgcagtattt gtcgtaagcc aaaaccatcg atgttgactt   4500

cctaattcag tctttaaacc gcaaaaggat tctgattcgc agatggcctg atctccaaac   4560

tcaggctggg gctctaactc gagcaagtgt cctatgctgt aggccgcagc ccttttggtt   4620

cgacgacgtg cgtggttatg agacgctcgg ctgttttgcg ctaagctggc cgtatcgagt   4680

aaattctaca ggcacctgcg aggcaagcaa tctactaatg tttatttttc gtccaaccta   4740

attgtggttt caaagcgcta tcaggtgggg ggtaagagga atgtgagtgg aaagcgaaaa   4800

taactggcag ctggggtcag atcccgtgat gccacctctt gtggtatttt gaaacgcgtg   4860

ttgcgattgg ccgcgagaac ggaaaggaat atatttactg ccgatcgcat tttggcctca   4920

aataaatctt gagcttttgg acatagatta tatgttcttt cttggaagct ctttcagcta   4980

atagtgaagt gtttcctact aaggatcgcc tccaaacgtt ccaactacgg gcggaggttg   5040

caaagaaaac gggtctctca gcgaattgtt ctcatccatg agtgagtcct ctccgtcctt   5100

tcctcgcgcc tggcaataaa gcctccttcg gaggagctcc gtctagagaa taattgctgc   5160

ctttctgact ttcggactag cgccaaccgc gaaccacacc accacaccat cactgtcacc   5220

cgtcatagtt catccctctc tccttataaa gcatctaata ggttccacaa ttgtttgcca   5280

aaaaatctct tagcatagcc caattgatta cgaaacacct gcaggccatg aacacaaaat   5340

cactcgactt ttatgaacca cttgaaattg atggtcaaaa atacattaag atgactaaga   5400

aggaagacct aggcgtatat gaggccggag tgacacagga agcatttact gccaaggata   5460

agtatgatta caaaggaatt gtagagaatt tggaaaggta tgggctttgt atagttccaa   5520

gctttataga accatccaaa tgtgatcaga tcttagagga gctcgatccc catttctaca   5580

gacacgacgc atggcagggt tcaccattcc caaaggaaac aacggtggtg acaagagcag   5640

tcctccactc tcctactgtc ttgaaggagg ttgtgtctga ccgtctgttt tgcgatatgg   5700

caaaccattt tttaaatgag gaaaattact tcttgactgg aaatgtcatc aggaagtgtt   5760

caagtggtat tcagctaaac tctggtattg tttacaaggt tggtgctggt gctggtgatc   5820

agggctacca tcgagaagac catatccatc ataccattca tcaagcacgt gacagtttcc   5880

aatacggaaa ggaaacgcta ctcggagtag gggttgcttt cacggatatg aacaaagcta   5940

atggggctac gcgtgtgatt atcggttcgc acttgtgggg cccacatgat tcgtgtggga   6000

aattcgacaa gaggatggag tttcatgtaa atgctgccaa gggtgacgcg gttttgtttt   6060

taggcagcct ttaccatgcc gcaagtgcga accataccct agaagataga attgcgggat   6120

atttctttat gtcacagggc tacttgaaac aagaggaaaa tcttcacttt ggaacagacc   6180

ctgaattctt caaagacatg ccactagaga ccttgaaact cttgggattg acgaccagtg   6240

agccatattg tggtcacata gattacaaaa gtccaggaca tattgcgaac cccaacttgt   6300

ttgaaaatga agttgagaaa ggatactacg gtgagacaat caagattatt tatgacgata   6360

aagagtaagg ccgcctcggc cggatccacg tccgacggcg gcccacgggt cccaggcctc   6420

ggagatccgt cccccttttc ctttgtcgat atcatgtaat tagttatgtc acgcttacat   6480

tcacgccctc cccccacatc cgctctaacc gaaaaggaag gagttagaca acctgaagtc   6540

taggtcccta tttatttttt tatagttatg ttagtattaa gaacgttatt tatatttcaa   6600

atttttcttt tttttctgta cagacgcgtg tacgcatgta acattatact gaaaaccttg   6660

cttgagaagg ttttgggacg ctcgaaggct ttaatttgca agcta                   6705


<210>  3
<211>  6509
<212>  DNA
<213>  artificial

<220>
<223>  pPM2d_pPGK_BIO3_pPGI_BIO4 expression vector

<400>  3
ccggtgaatt cgtgatctga agcttcgtac cgagctctga gcaaaaggcc agcaaaaggc     60

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga    120

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata    180

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac    240

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcaat gctcacgctg    300

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc    360

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag    420

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt    480

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt    540

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg    600

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac    660

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacgggag ctcttaatta    720

agcggccgct taattaaggg cccaagccac gccggcgcca aggcccaagt tggtacccag    780

ccgatcacgc ctgctctgag tttggctgga gcagcaaatc tcatgagatt atcaaaaagg    840

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat    900

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc    960

tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg   1020

gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct   1080

ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca   1140

actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg   1200

ccagttaata gtttgcgcaa cgttgttgcc attgctgcag gcatcgtggt gtcacgctcg   1260

tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc   1320

cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag   1380

ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg   1440

ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag   1500

tgtatgcggc gaccgagttg ctcttgcccg gcgtcaacac gggataatac cgcgccacat   1560

agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg   1620

atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca   1680

gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca   1740

aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat   1800

tattgaagca tttatcaggg ttattgtctc atgataaccg aggtttaaat taaggtacat   1860

aacaaaaatt caatgttcaa agacgcacat accaagactt actaatcgca gaatgttggt   1920

gcagtatttg tcgtaagcca aaaccatcga tgttgacttc ctaattcagt ctttaaaccg   1980

caaaaggatt ctgattcgca gatggcctga tctccaaact caggctgggg ctctaactcg   2040

agcaagtgtc ctatgctgta ggccgcagcc cttttggttc gacgacgtgc gtggttatga   2100

gacgctcggc tgttttgcgc taagctggcc gtatcgagta aattctacag gcacctgcga   2160

ggcaagcaat ctactaatgt ttatttttcg tccaacctaa ttgtggtttc aaagcgctat   2220

caggtggggg gtaagaggaa tgtgagtgga aagcgaaaat aactggcagc tggggtcaga   2280

tcccgtgatg ccacctcttg tggtattttg aaacgcgtgt tgcgattggc cgcgagaacg   2340

gaaaggaata tatttactgc cgatcgcatt ttggcctcaa ataaatcttg agcttttgga   2400

catagattat atgttctttc ttggaagctc tttcagctaa tagtgaagtg tttcctacta   2460

aggatcgcct ccaaacgttc caactacggg cggaggttgc aaagaaaacg ggtctctcag   2520

cgaattgttc tcatccatga gtgagtcctc tccgtccttt cctcgcgcct ggcaataaag   2580

cctccttcgg aggagctccg tctagagaat aattgctgcc tttctgactt tcggactagc   2640

gccaaccgcg aaccacacca ccacaccatc actgtcaccc gtcatagttc atccctctct   2700

ccttataaag catctaatag gttccacaat tgtttgccaa aaaatctctt agcatagccc   2760

aattgattac gaaacacctg caggccatgt cccaagaaat ttcatataca ccagatgtcg   2820

cggaactgct agactttgat aaaaaacata tttggcatcc ttatacgtca ttgagttcac   2880

cattgaacgt ttatccggta aagagtgctc acggatgcaa gctggtgttg gataccgact   2940

caccagtgga cgtcgaggtg atcgacgcca tgtcgtcgtg gtggtgtgtt attcacgggt   3000

acaataatcc agaattaaat gaggccctta ccaagcagat gttaaagttt tctcacgtcc   3060

ttcttggtgg attcacccat aaaggagctg tgaatctagt ccaaaaactt ttaaaagtga   3120

ttgacgaacc ctctttgcag tactgtttcc tcgcagattc tggctcagta gcagtggaag   3180

tagctttgaa gatggcttta caatcaaaca tgtcagggga agctactaaa aatagaacaa   3240

aatttttgac aatcaagaac gggtatcatg gtgatacatt tggcgctatg agtgtttgtg   3300

atcctgagaa ttctatgcat catatctaca acgatcgact cagtgagaac atcttcgccc   3360

aagctccctc tattgtcgat ggtcttccaa ccagccagaa cggtttcgag gaccattgga   3420

atgcagaaga agttaccgat ctcaagaagc aatttgaatt gcatagtgat gagatctgtg   3480

ctgtgatttt ggagcctatc ttacagggtg caggaggttt gcgaccatac catccacagt   3540

tcctaatcga agttcagaaa ctatgtaacc aatacgacgt tttattcatc atggacgaga   3600

ttgctacggg atttggtaga acaggtgaga ttttcgcatt caagcactgt caaaaatacc   3660

aggaccaacg tggcatcagt ccttccgatc agatcaaagt tgttcctgac atattgtgcg   3720

ttgggaaggg cttaaccagt ggatatatga ctatgagtgc agtggtagtc aacgacaaag   3780

ttgcttccag aatctcttct ccaaatagcc ctactggtgg ctgcttcatg catggcccca   3840

ccttcatggg caatgccctg gcatgcagtg tggcagaaaa gtctatggat atactactgc   3900

gtggcgagtg gagaaaacaa gtgtctgcaa ttgaagacca aatttataga gaactatacc   3960

agtacatcaa gaacccagat aatgggctca ttggaactgt tgttaagcgt gtgtcagtta   4020

ttggagctgt aggtatcgta gagctataca agaagacaga tcccgagtgg ttccagaaaa   4080

agtttatatc caagggagta catatccgac ctttcaactg cctgtgttac attatgccac   4140

catatgtgat cacgacagag gaattgacga aggttaatca agtcttgatt gaagtattac   4200

atgagtggaa atcccacata aaccaatgag gccgcctcgg ccggatccac gtccgacggc   4260

ggcccacggg tcccaggcct cggagatccg tccccctttt cctttgtcga tatcatgtaa   4320

ttagttatgt cacgcttaca ttcacgccct ccccccacat ccgctctaac cgaaaaggaa   4380

ggagttagac aacctgaagt ctaggtccct atttattttt ttatagttat gttagtatta   4440

agaacgttat ttatatttca aatttttctt ttttttctgt acagacgcgt gtacgcatgt   4500

aacattatac tgaaaacctt gcttgagaag gttttgggac gctcgaaggc tttaatttgc   4560

aagctaccgg cgccaaggcc cagcactttc tctggagatt agtaatcgat ggtcaggatg   4620

ggaaccgaat gtctttggct ggcctttccc caaatttgag aacaaaattc aattgctgag   4680

gtaatacttt tttccccata caagaaaggc catcgtgtaa ttatctctta ccttctacta   4740

ttcgagaagt tgtaaccaaa tggctgataa catcgaaacc atccgtcctg gaatcaacta   4800

ccaggacaaa ctattgaccg aaatagacat tcttgatgat gttaaacaac tgtcaacgca   4860

gatggaacag gaagggaaag gattcgtctt ccctaaagat cattactcca agataaaatc   4920

actaaagggg ttgcaagtga agctgttgaa agaaatgcaa gagttggctg aaattcagca   4980

gtctaggcat caagacgaaa ctgcatacag gcagaagctt caagacttgg aagatactac   5040

atcagaactt agaaacgttg ctttgacgta ataggtcacc tgtgttacta gatgtcggat   5100

gtctgtgatt gcagtaacac ccggcattcg gtcagctgtc tacctttcag gatatcctcc   5160

ccccaccgag ctcggacgcc tttctcgccc acccaccacg caaagttccg cccaccttat   5220

actttgtgga agtcttttcg ccgcgcacca cacttgcccg ttcgcagaaa aagaaattcc   5280

aggtagccct tattccgtca ggcaataaat atataagcga ttgcagacaa tctgacgtcc   5340

catccccttg tctatttaaa cctcctaggt tgcttaaatt taaaatctat tcgagtccca   5400

acctttccat tcttccggaa taattcaact ccaaccaatt gataaacacc tgcaggccat   5460

gaacagcaaa tctcaacaac aagaacaaca accaattgta ttcgtcaccg gtacagacac   5520

tgatgttggt aaaacctttg tatcaacatt attggtacac aaatggaaag ctgcatactg   5580

gaaacccgta caaactggaa ttgagtcaga tcaaggtgac tccgagacat tgaaaaattt   5640

caaaatagcc gcatcaactt ggcaaccacc tatattcacg cccacttatg cgctgcagaa   5700

gcctctatct ccgctccagg ccatggagta cgaacctaat gtcgacatca ggttgttgga   5760

tttcgtagtt cctgaagagt ggagcgcaga gaatccattg gtcgtagaag gagccggcgg   5820

ggtttgcgtt cccatcactc gtaaattgga aattacgacg gatctaatta aacatctgat   5880

tgagactagc ggccatccag tgtacgtagt tgtcgtggca cgcagcgggc tagggactct   5940

gaatcataca ttgctgactt ggaatcatct ttgcgataat ggcttgagaa gccacctttt   6000

tggggtcatt ctcaatgggg aaccgaatga aggcaacgtg caggccctga agaagttcgg   6060

tgtcaatatt atggcacagg ttgcacaatg tactacggca catgatcagg atatggcgtt   6120

gcatgaactg ccatcggtgg agtcattaat gacccaacaa gacgtagaat agggccgcct   6180

cggccggatc cacgtccgac ggcggcccac gggtcccagg cctcggagat ccgtccccct   6240

tttcctttgt cgatatcatg taattagtta tgtcacgctt acattcacgc cctcccccca   6300

catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc cctatttatt   6360

tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt cttttttttc   6420

tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag aaggttttgg   6480

gacgctcgaa ggctttaatt tgcaagcta                                     6509


<210>  4
<211>  1041
<212>  DNA
<213>  artificial

<220>
<223>  BIO1 gene

<400>  4
atgaacacaa aatcactcga cttttatgaa ccacttgaaa ttgatggtca aaaatacatt     60

aagatgacta agaaggaaga cctaggcgta tatgaggccg gagtgacaca ggaagcattt    120

actgccaagg ataagtatga ttacaaagga attgtagaga atttggaaag gtatgggctt    180

tgtatagttc caagctttat agaaccatcc aaatgtgatc agatcttaga ggagctcgat    240

ccccatttct acagacacga cgcatggcag ggttcaccat tcccaaagga aacaacggtg    300

gtgacaagag cagtcctcca ctctcctact gtcttgaagg aggttgtgtc tgaccgtctg    360

ttttgcgata tggcaaacca ttttttaaat gaggaaaatt acttcttgac tggaaatgtc    420

atcaggaagt gttcaagtgg tattcagcta aactctggta ttgtttacaa ggttggtgct    480

ggtgctggtg atcagggcta ccatcgagaa gaccatatcc atcataccat tcatcaagca    540

cgtgacagtt tccaatacgg aaaggaaacg ctactcggag taggggttgc tttcacggat    600

atgaacaaag ctaatggggc tacgcgtgtg attatcggtt cgcacttgtg gggcccacat    660

gattcgtgtg ggaaattcga caagaggatg gagtttcatg taaatgctgc caagggtgac    720

gcggttttgt ttttaggcag cctttaccat gccgcaagtg cgaaccatac cctagaagat    780

agaattgcgg gatatttctt tatgtcacag ggctacttga aacaagagga aaatcttcac    840

tttggaacag accctgaatt cttcaaagac atgccactag agaccttgaa actcttggga    900

ttgacgacca gtgagccata ttgtggtcac atagattaca aaagtccagg acatattgcg    960

aaccccaact tgtttgaaaa tgaagttgag aaaggatact acggtgagac aatcaagatt   1020

atttatgacg ataaagagta a                                             1041


<210>  5
<211>  1191
<212>  DNA
<213>  artificial

<220>
<223>  BIO2 gene

<400>  5
atgaacagac agtcgttgat ggcaggcagg agactcttct ccaaagtcag agtggtcaga     60

aaaccatcca cgttggccaa cgagttgggg tctttgtacg agcataacca accaattttt    120

gagcctccat cccctgaaaa aaaggtgtcc gctttagact atgcattttc tttgaaatct    180

ccggtttcaa cttggactaa agaacagctt agagagattt acaacactcc tctgatggaa    240

cttgttcacc gtgctcagat atatcatcgc aattttcaca atccttcgga agttcaaatt    300

tgcaacttgg tgaatatcaa gtcgggaggt tgtactgagg actgcaagta ctgttcccaa    360

tcggtgaaca atgacaccaa cttgaaagct gaaaagctta tgaccgtgga tgaggttgtt    420

gagcaggcta agattgccaa atccaacggc gcaacaagag tctgtttagg agcagcatac    480

agaactgtta gcaccagaaa gagagcgtta gaaagaatca ccacaatggt gaaggaagtc    540

aacaagctcg gcctggaaag ttgtgtcaca ctcggaatga ttgaagaaga acatgctaga    600

aagcttaagg acgcaggatt gaccgcatac aaccacaaca tcgacacctc aagagaacac    660

tatcctaaca tcattactac gagaacttat gatgatagac tgaagacgat tgacaacgtc    720

cagaaggccg gaatcagtgc ttgtaccggt ggaattctag gtcttggaga gacagtggaa    780

gaccacattg gatttctgta caccctgtgt accatgaaac agcaccctga atcactgccg    840

atcaacagat tggttccaat taaaggaact cccatcgcag acgagttggc ccgtgacaac    900

tccaagaagc ttaaattcga gtcaatgttg agaaccattg ccactgccag aatggtgatg    960

ccaaccagta ttatcagatt ggcagctggt agatacacta tgaaagagac agagcaattc   1020

ttatgcttta tggctggatg caatgcaatc tttagcggaa agaagatgtt gactactatg   1080

tgcaatgggt ttgatgagga taaagaactt ttagccaaat ggggtatgaa accgatgcag   1140

agtttcgcta gtaaacgtcc ttcgtcaatc gtggaaactt gccatatatg a            1191


<210>  6
<211>  1443
<212>  DNA
<213>  artificial

<220>
<223>  BIO3 gene

<400>  6
atgtcccaag aaatttcata tacaccagat gtcgcggaac tgctagactt tgataaaaaa     60

catatttggc atccttatac gtcattgagt tcaccattga acgtttatcc ggtaaagagt    120

gctcacggat gcaagctggt gttggatacc gactcaccag tggacgtcga ggtgatcgac    180

gccatgtcgt cgtggtggtg tgttattcac gggtacaata atccagaatt aaatgaggcc    240

cttaccaagc agatgttaaa gttttctcac gtccttcttg gtggattcac ccataaagga    300

gctgtgaatc tagtccaaaa acttttaaaa gtgattgacg aaccctcttt gcagtactgt    360

ttcctcgcag attctggctc agtagcagtg gaagtagctt tgaagatggc tttacaatca    420

aacatgtcag gggaagctac taaaaataga acaaaatttt tgacaatcaa gaacgggtat    480

catggtgata catttggcgc tatgagtgtt tgtgatcctg agaattctat gcatcatatc    540

tacaacgatc gactcagtga gaacatcttc gcccaagctc cctctattgt cgatggtctt    600

ccaaccagcc agaacggttt cgaggaccat tggaatgcag aagaagttac cgatctcaag    660

aagcaatttg aattgcatag tgatgagatc tgtgctgtga ttttggagcc tatcttacag    720

ggtgcaggag gtttgcgacc ataccatcca cagttcctaa tcgaagttca gaaactatgt    780

aaccaatacg acgttttatt catcatggac gagattgcta cgggatttgg tagaacaggt    840

gagattttcg cattcaagca ctgtcaaaaa taccaggacc aacgtggcat cagtccttcc    900

gatcagatca aagttgttcc tgacatattg tgcgttggga agggcttaac cagtggatat    960

atgactatga gtgcagtggt agtcaacgac aaagttgctt ccagaatctc ttctccaaat   1020

agccctactg gtggctgctt catgcatggc cccaccttca tgggcaatgc cctggcatgc   1080

agtgtggcag aaaagtctat ggatatacta ctgcgtggcg agtggagaaa acaagtgtct   1140

gcaattgaag accaaattta tagagaacta taccagtaca tcaagaaccc agataatggg   1200

ctcattggaa ctgttgttaa gcgtgtgtca gttattggag ctgtaggtat cgtagagcta   1260

tacaagaaga cagatcccga gtggttccag aaaaagttta tatccaaggg agtacatatc   1320

cgacctttca actgcctgtg ttacattatg ccaccatatg tgatcacgac agaggaattg   1380

acgaaggtta atcaagtctt gattgaagta ttacatgagt ggaaatccca cataaaccaa   1440

tga                                                                 1443


<210>  7
<211>  714
<212>  DNA
<213>  artificial

<220>
<223>  BIO4 gene

<400>  7
atgaacagca aatctcaaca acaagaacaa caaccaattg tattcgtcac cggtacagac     60

actgatgttg gtaaaacctt tgtatcaaca ttattggtac acaaatggaa agctgcatac    120

tggaaacccg tacaaactgg aattgagtca gatcaaggtg actccgagac attgaaaaat    180

ttcaaaatag ccgcatcaac ttggcaacca cctatattca cgcccactta tgcgctgcag    240

aagcctctat ctccgctcca ggccatggag tacgaaccta atgtcgacat caggttgttg    300

gatttcgtag ttcctgaaga gtggagcgca gagaatccat tggtcgtaga aggagccggc    360

ggggtttgcg ttcccatcac tcgtaaattg gaaattacga cggatctaat taaacatctg    420

attgagacta gcggccatcc agtgtacgta gttgtcgtgg cacgcagcgg gctagggact    480

ctgaatcata cattgctgac ttggaatcat ctttgcgata atggcttgag aagccacctt    540

tttggggtca ttctcaatgg ggaaccgaat gaaggcaacg tgcaggccct gaagaagttc    600

ggtgtcaata ttatggcaca ggttgcacaa tgtactacgg cacatgatca ggatatggcg    660

ttgcatgaac tgccatcggt ggagtcatta atgacccaac aagacgtaga atag          714


<210>  8
<211>  1686
<212>  DNA
<213>  artificial

<220>
<223>  BIO5 gene

<400>  8
atgaacagag taggggcagt gttcctattt gtatatgaaa gaaatttttt tttgtctatt     60

gttccagatc gtcacaggac ggaaataaga atgtctagtt cagaaaggtc agaagtcaag    120

tttgacaagc actttaattg gtggtcccta ttaggtatcg cgttctcatt aagttgctca    180

tgggtcggta tctcagcgtc gatggccgtt ggtattgcca gtggagggcc actgcttatc    240

atctatgggt tgataattgc tgcttttttc agtctcatgt gtggtatatc tctgggagat    300

tttgctgcta tcctgccaaa cagcagcggt ggttcatttt gggttcttaa aatgttggaa    360

caagaatcag tcactttgaa aacccctgag tacgaggacc cttctgacga tgatgaagaa    420

gtgttcctcg agaattattg tcaaactttc aacgtggaag tttcttctaa atttcaaaag    480

gtttcttcca tggttgtagg gttgctgaac tatttcggtg ccatttttac taccgcaagt    540

atctgctcat ctttgtcaat gagctgtatc ggtattcata agttgttgca tccggactac    600

gagttaaagc actggcatgt ttttgtgggt tacgagtgta tcaatgccgt tttgacactt    660

ttcaacattt attcaactcc gttgccctat atctctcagt ttgggctcta tacgtctcta    720

ttgtctttcg ccatgacttt cattatttgt attgtttcaa gatctgacaa caccgtagac    780

ccatggccca aagcttctaa tatatttggg agctttgata atcaaacagg ctggaattcg    840

tctggaatgg cgtttgttgt cggtttggtc aatccgatct gggcatttgt tggcattgac    900

tctgctacgc acatgattga tgaagtgggt tatagtaagt cacgtttctt agttcccaaa    960

gttattatca ctaccatcat tgtgggcttt gtaactagtt ttatttattg cgttggtttg   1020

tttttctgca tcactgacca aacggcagtc gttgagtcta ttttacctat cgtagaaata   1080

ttttaccagg ccactggtaa taggaatctc agtgtcttcc tgcaatgtat gtgtatcaca   1140

acaggttttg tttcaggcat tgcaagtgga acctggcaaa gtcgaatcct ccaatcattc   1200

gggaaaagtt acgcaccatt ttataaagag ggttccttgg gaaacaaatc cttgaagaag   1260

ctagcagtgt tgacacctgg gtttaagtct ccattatatg cccatttttt gtcacaaata   1320

tgtgtaacga taattggctg tatatttatg ggatctagta ccgctttcaa cgcaattatc   1380

actgcatgca tcaccctgtt actaatgtcg tacgcagttc cttcttttat attcctgttc   1440

gttattaaaa aggaaaaatt cattcataga atcgagagtg acgtaaattg tgtcagcagg   1500

cctaaccgtc gtcgtatgtc tatgattcct catattatat gtattctatg gaccttgttc   1560

tgcctggtat ttttatcttt cccatataca ctaccggtta ctgcaggaaa catgaattac   1620

acctcagtag tgtatgcagt agttttctgc attatcagca tcgttgtttt ccctacatgc   1680

atctaa                                                              1686


<210>  9
<211>  1314
<212>  DNA
<213>  artificial

<220>
<223>  BIO6 gene

<400>  9
atgcttgaac atcaattaac ccaagaagat ctcgaatttg ataaaaaaca catatggcac     60

ccgtacacat caataactac tccattgaaa gtgtacccta ttaccaaagc agaaggtagt    120

tatttgtacc tcgataatgg taccaaggta gtagatggta tggcaagctg gtggtgcgtt    180

cagcaaggat acaacaatca tcgcctaaat gcagccgcca tttcacagat taataaaatg    240

tcacatgtga tgtttggtgg aattactcat aaggctggaa ttgatttttg taaaaagttg    300

ctcgctttgt taccagatac cctggaatgt gctttactgg cggattctgg gtctatttct    360

gtcgacattg caatgaagat ggctttaaga tatcatcatt cattggggaa tacaacgaaa    420

aaaagattct tgacaattaa gaagggctac cacggtgacg cttttggagc cgtatcagtt    480

tgtgaccctg tcaattcaag gcataatact tataacgggt ttctcgctga aaacatattc    540

tgcaaggctc cagaagtccg ctttgattgt cgtgaaaagg acgttgagaa actggtagag    600

gaactcgacg taaagccatt tgctgagatt attgataaac accacagtga aatttctggt    660

gttgtgatgg aaagcatcgt acagggcgct ggtggtctaa gaatgtatca tccatatttc    720

ctgaaacgtg tccgtgcact ctgcaacgac tttaatattt tgttgattct tgatgaagtt    780

gcagtggggc ttggaagaac gggtatgctg tttggatttg agcatgcagg gatagtgcct    840

gacatagtct gtctaggtaa gactttgacg gccggttatt tgacgttatc tgcaacagtt    900

accaccagag agattggtga tcagatttcc agtggacctg agggttgctt catgcacgga    960

caaacctata tggcaaatcc gttagcatgc gctgttgcaa gtgaaaactt gtcgatctta   1020

atggaaggta aatggaaatc tcaagttcgg caaatagaag tccagctgaa gaaagagctg   1080

gtgcccttac tggaacaccc catcgtggct gatgtaagaa ttctaggggc tattggtgtt   1140

gtcgaggtta caaaacgtgt gaacgtcgaa gtcttacaag agaaatttat taaggcaggt   1200

gcgtggatta gacctttcgg taacataatc tacattctac ctccatacat aattacttcc   1260

gaggagttga ccgtcttaac agaagctatc agatctgttc tagactttat ttag         1314


<210>  10
<211>  346
<212>  PRT
<213>  artificial

<220>
<223>  BIO1 protein

<400>  10

Met Asn Thr Lys Ser Leu Asp Phe Tyr Glu Pro Leu Glu Ile Asp Gly 
1               5                   10                  15      


Gln Lys Tyr Ile Lys Met Thr Lys Lys Glu Asp Leu Gly Val Tyr Glu 
            20                  25                  30          


Ala Gly Val Thr Gln Glu Ala Phe Thr Ala Lys Asp Lys Tyr Asp Tyr 
        35                  40                  45              


Lys Gly Ile Val Glu Asn Leu Glu Arg Tyr Gly Leu Cys Ile Val Pro 
    50                  55                  60                  


Ser Phe Ile Glu Pro Ser Lys Cys Asp Gln Ile Leu Glu Glu Leu Asp 
65                  70                  75                  80  


Pro His Phe Tyr Arg His Asp Ala Trp Gln Gly Ser Pro Phe Pro Lys 
                85                  90                  95      


Glu Thr Thr Val Val Thr Arg Ala Val Leu His Ser Pro Thr Val Leu 
            100                 105                 110         


Lys Glu Val Val Ser Asp Arg Leu Phe Cys Asp Met Ala Asn His Phe 
        115                 120                 125             


Leu Asn Glu Glu Asn Tyr Phe Leu Thr Gly Asn Val Ile Arg Lys Cys 
    130                 135                 140                 


Ser Ser Gly Ile Gln Leu Asn Ser Gly Ile Val Tyr Lys Val Gly Ala 
145                 150                 155                 160 


Gly Ala Gly Asp Gln Gly Tyr His Arg Glu Asp His Ile His His Thr 
                165                 170                 175     


Ile His Gln Ala Arg Asp Ser Phe Gln Tyr Gly Lys Glu Thr Leu Leu 
            180                 185                 190         


Gly Val Gly Val Ala Phe Thr Asp Met Asn Lys Ala Asn Gly Ala Thr 
        195                 200                 205             


Arg Val Ile Ile Gly Ser His Leu Trp Gly Pro His Asp Ser Cys Gly 
    210                 215                 220                 


Lys Phe Asp Lys Arg Met Glu Phe His Val Asn Ala Ala Lys Gly Asp 
225                 230                 235                 240 


Ala Val Leu Phe Leu Gly Ser Leu Tyr His Ala Ala Ser Ala Asn His 
                245                 250                 255     


Thr Leu Glu Asp Arg Ile Ala Gly Tyr Phe Phe Met Ser Gln Gly Tyr 
            260                 265                 270         


Leu Lys Gln Glu Glu Asn Leu His Phe Gly Thr Asp Pro Glu Phe Phe 
        275                 280                 285             


Lys Asp Met Pro Leu Glu Thr Leu Lys Leu Leu Gly Leu Thr Thr Ser 
    290                 295                 300                 


Glu Pro Tyr Cys Gly His Ile Asp Tyr Lys Ser Pro Gly His Ile Ala 
305                 310                 315                 320 


Asn Pro Asn Leu Phe Glu Asn Glu Val Glu Lys Gly Tyr Tyr Gly Glu 
                325                 330                 335     


Thr Ile Lys Ile Ile Tyr Asp Asp Lys Glu 
            340                 345     


<210>  11
<211>  396
<212>  PRT
<213>  artificial

<220>
<223>  BIO2 protein

<400>  11

Met Asn Arg Gln Ser Leu Met Ala Gly Arg Arg Leu Phe Ser Lys Val 
1               5                   10                  15      


Arg Val Val Arg Lys Pro Ser Thr Leu Ala Asn Glu Leu Gly Ser Leu 
            20                  25                  30          


Tyr Glu His Asn Gln Pro Ile Phe Glu Pro Pro Ser Pro Glu Lys Lys 
        35                  40                  45              


Val Ser Ala Leu Asp Tyr Ala Phe Ser Leu Lys Ser Pro Val Ser Thr 
    50                  55                  60                  


Trp Thr Lys Glu Gln Leu Arg Glu Ile Tyr Asn Thr Pro Leu Met Glu 
65                  70                  75                  80  


Leu Val His Arg Ala Gln Ile Tyr His Arg Asn Phe His Asn Pro Ser 
                85                  90                  95      


Glu Val Gln Ile Cys Asn Leu Val Asn Ile Lys Ser Gly Gly Cys Thr 
            100                 105                 110         


Glu Asp Cys Lys Tyr Cys Ser Gln Ser Val Asn Asn Asp Thr Asn Leu 
        115                 120                 125             


Lys Ala Glu Lys Leu Met Thr Val Asp Glu Val Val Glu Gln Ala Lys 
    130                 135                 140                 


Ile Ala Lys Ser Asn Gly Ala Thr Arg Val Cys Leu Gly Ala Ala Tyr 
145                 150                 155                 160 


Arg Thr Val Ser Thr Arg Lys Arg Ala Leu Glu Arg Ile Thr Thr Met 
                165                 170                 175     


Val Lys Glu Val Asn Lys Leu Gly Leu Glu Ser Cys Val Thr Leu Gly 
            180                 185                 190         


Met Ile Glu Glu Glu His Ala Arg Lys Leu Lys Asp Ala Gly Leu Thr 
        195                 200                 205             


Ala Tyr Asn His Asn Ile Asp Thr Ser Arg Glu His Tyr Pro Asn Ile 
    210                 215                 220                 


Ile Thr Thr Arg Thr Tyr Asp Asp Arg Leu Lys Thr Ile Asp Asn Val 
225                 230                 235                 240 


Gln Lys Ala Gly Ile Ser Ala Cys Thr Gly Gly Ile Leu Gly Leu Gly 
                245                 250                 255     


Glu Thr Val Glu Asp His Ile Gly Phe Leu Tyr Thr Leu Cys Thr Met 
            260                 265                 270         


Lys Gln His Pro Glu Ser Leu Pro Ile Asn Arg Leu Val Pro Ile Lys 
        275                 280                 285             


Gly Thr Pro Ile Ala Asp Glu Leu Ala Arg Asp Asn Ser Lys Lys Leu 
    290                 295                 300                 


Lys Phe Glu Ser Met Leu Arg Thr Ile Ala Thr Ala Arg Met Val Met 
305                 310                 315                 320 


Pro Thr Ser Ile Ile Arg Leu Ala Ala Gly Arg Tyr Thr Met Lys Glu 
                325                 330                 335     


Thr Glu Gln Phe Leu Cys Phe Met Ala Gly Cys Asn Ala Ile Phe Ser 
            340                 345                 350         


Gly Lys Lys Met Leu Thr Thr Met Cys Asn Gly Phe Asp Glu Asp Lys 
        355                 360                 365             


Glu Leu Leu Ala Lys Trp Gly Met Lys Pro Met Gln Ser Phe Ala Ser 
    370                 375                 380                 


Lys Arg Pro Ser Ser Ile Val Glu Thr Cys His Ile 
385                 390                 395     


<210>  12
<211>  480
<212>  PRT
<213>  artificial

<220>
<223>  BIO3 protein


<220>
<221>  misc_feature
<222>  (229)..(229)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (384)..(384)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Met Ser Gln Glu Ile Ser Tyr Thr Pro Asp Val Ala Glu Leu Leu Asp 
1               5                   10                  15      


Phe Asp Lys Lys His Ile Trp His Pro Tyr Thr Ser Leu Ser Ser Pro 
            20                  25                  30          


Leu Asn Val Tyr Pro Val Lys Ser Ala His Gly Cys Lys Leu Val Leu 
        35                  40                  45              


Asp Thr Asp Ser Pro Val Asp Val Glu Val Ile Asp Ala Met Ser Ser 
    50                  55                  60                  


Trp Trp Cys Val Ile His Gly Tyr Asn Asn Pro Glu Leu Asn Glu Ala 
65                  70                  75                  80  


Leu Thr Lys Gln Met Leu Lys Phe Ser His Val Leu Leu Gly Gly Phe 
                85                  90                  95      


Thr His Lys Gly Ala Val Asn Leu Val Gln Lys Leu Leu Lys Val Ile 
            100                 105                 110         


Asp Glu Pro Ser Leu Gln Tyr Cys Phe Leu Ala Asp Ser Gly Ser Val 
        115                 120                 125             


Ala Val Glu Val Ala Leu Lys Met Ala Leu Gln Ser Asn Met Ser Gly 
    130                 135                 140                 


Glu Ala Thr Lys Asn Arg Thr Lys Phe Leu Thr Ile Lys Asn Gly Tyr 
145                 150                 155                 160 


His Gly Asp Thr Phe Gly Ala Met Ser Val Cys Asp Pro Glu Asn Ser 
                165                 170                 175     


Met His His Ile Tyr Asn Asp Arg Leu Ser Glu Asn Ile Phe Ala Gln 
            180                 185                 190         


Ala Pro Ser Ile Val Asp Gly Leu Pro Thr Ser Gln Asn Gly Phe Glu 
        195                 200                 205             


Asp His Trp Asn Ala Glu Glu Val Thr Asp Leu Lys Lys Gln Phe Glu 
    210                 215                 220                 


Leu His Ser Asp Xaa Ile Cys Ala Val Ile Leu Glu Pro Ile Leu Gln 
225                 230                 235                 240 


Gly Ala Gly Gly Leu Arg Pro Tyr His Pro Gln Phe Leu Ile Glu Val 
                245                 250                 255     


Gln Lys Leu Cys Asn Gln Tyr Asp Val Leu Phe Ile Met Asp Glu Ile 
            260                 265                 270         


Ala Thr Gly Phe Gly Arg Thr Gly Glu Ile Phe Ala Phe Lys His Cys 
        275                 280                 285             


Gln Lys Tyr Gln Asp Gln Arg Gly Ile Ser Pro Ser Asp Gln Ile Lys 
    290                 295                 300                 


Val Val Pro Asp Ile Leu Cys Val Gly Lys Gly Leu Thr Ser Gly Tyr 
305                 310                 315                 320 


Met Thr Met Ser Ala Val Val Val Asn Asp Lys Val Ala Ser Arg Ile 
                325                 330                 335     


Ser Ser Pro Asn Ser Pro Thr Gly Gly Cys Phe Met His Gly Pro Thr 
            340                 345                 350         


Phe Met Gly Asn Ala Leu Ala Cys Ser Val Ala Glu Lys Ser Met Asp 
        355                 360                 365             


Ile Leu Leu Arg Gly Glu Trp Arg Lys Gln Val Ser Ala Ile Glu Xaa 
    370                 375                 380                 


Gln Ile Tyr Arg Glu Leu Tyr Gln Tyr Ile Lys Asn Pro Asp Asn Gly 
385                 390                 395                 400 


Leu Ile Gly Thr Val Val Lys Arg Val Ser Val Ile Gly Ala Val Gly 
                405                 410                 415     


Ile Val Glu Leu Tyr Lys Lys Thr Asp Pro Glu Trp Phe Gln Lys Lys 
            420                 425                 430         


Phe Ile Ser Lys Gly Val His Ile Arg Pro Phe Asn Cys Leu Cys Tyr 
        435                 440                 445             


Ile Met Pro Pro Tyr Val Ile Thr Thr Glu Glu Leu Thr Lys Val Asn 
    450                 455                 460                 


Gln Val Leu Ile Glu Val Leu His Glu Trp Lys Ser His Ile Asn Gln 
465                 470                 475                 480 


<210>  13
<211>  237
<212>  PRT
<213>  artificial

<220>
<223>  BIO4 protein

<400>  13

Met Asn Ser Lys Ser Gln Gln Gln Glu Gln Gln Pro Ile Val Phe Val 
1               5                   10                  15      


Thr Gly Thr Asp Thr Asp Val Gly Lys Thr Phe Val Ser Thr Leu Leu 
            20                  25                  30          


Val His Lys Trp Lys Ala Ala Tyr Trp Lys Pro Val Gln Thr Gly Ile 
        35                  40                  45              


Glu Ser Asp Gln Gly Asp Ser Glu Thr Leu Lys Asn Phe Lys Ile Ala 
    50                  55                  60                  


Ala Ser Thr Trp Gln Pro Pro Ile Phe Thr Pro Thr Tyr Ala Leu Gln 
65                  70                  75                  80  


Lys Pro Leu Ser Pro Leu Gln Ala Met Glu Tyr Glu Pro Asn Val Asp 
                85                  90                  95      


Ile Arg Leu Leu Asp Phe Val Val Pro Glu Glu Trp Ser Ala Glu Asn 
            100                 105                 110         


Pro Leu Val Val Glu Gly Ala Gly Gly Val Cys Val Pro Ile Thr Arg 
        115                 120                 125             


Lys Leu Glu Ile Thr Thr Asp Leu Ile Lys His Leu Ile Glu Thr Ser 
    130                 135                 140                 


Gly His Pro Val Tyr Val Val Val Val Ala Arg Ser Gly Leu Gly Thr 
145                 150                 155                 160 


Leu Asn His Thr Leu Leu Thr Trp Asn His Leu Cys Asp Asn Gly Leu 
                165                 170                 175     


Arg Ser His Leu Phe Gly Val Ile Leu Asn Gly Glu Pro Asn Glu Gly 
            180                 185                 190         


Asn Val Gln Ala Leu Lys Lys Phe Gly Val Asn Ile Met Ala Gln Val 
        195                 200                 205             


Ala Gln Cys Thr Thr Ala His Asp Gln Asp Met Ala Leu His Glu Leu 
    210                 215                 220                 


Pro Ser Val Glu Ser Leu Met Thr Gln Gln Asp Val Glu 
225                 230                 235         


<210>  14
<211>  561
<212>  PRT
<213>  artificial

<220>
<223>  BIO5 protein

<400>  14

Met Asn Arg Val Gly Ala Val Phe Leu Phe Val Tyr Glu Arg Asn Phe 
1               5                   10                  15      


Phe Leu Ser Ile Val Pro Asp Arg His Arg Thr Glu Ile Arg Met Ser 
            20                  25                  30          


Ser Ser Glu Arg Ser Glu Val Lys Phe Asp Lys His Phe Asn Trp Trp 
        35                  40                  45              


Ser Leu Leu Gly Ile Ala Phe Ser Leu Ser Cys Ser Trp Val Gly Ile 
    50                  55                  60                  


Ser Ala Ser Met Ala Val Gly Ile Ala Ser Gly Gly Pro Leu Leu Ile 
65                  70                  75                  80  


Ile Tyr Gly Leu Ile Ile Ala Ala Phe Phe Ser Leu Met Cys Gly Ile 
                85                  90                  95      


Ser Leu Gly Asp Phe Ala Ala Ile Leu Pro Asn Ser Ser Gly Gly Ser 
            100                 105                 110         


Phe Trp Val Leu Lys Met Leu Glu Gln Glu Ser Val Thr Leu Lys Thr 
        115                 120                 125             


Pro Glu Tyr Glu Asp Pro Ser Asp Asp Asp Glu Glu Val Phe Leu Glu 
    130                 135                 140                 


Asn Tyr Cys Gln Thr Phe Asn Val Glu Val Ser Ser Lys Phe Gln Lys 
145                 150                 155                 160 


Val Ser Ser Met Val Val Gly Leu Leu Asn Tyr Phe Gly Ala Ile Phe 
                165                 170                 175     


Thr Thr Ala Ser Ile Cys Ser Ser Leu Ser Met Ser Cys Ile Gly Ile 
            180                 185                 190         


His Lys Leu Leu His Pro Asp Tyr Glu Leu Lys His Trp His Val Phe 
        195                 200                 205             


Val Gly Tyr Glu Cys Ile Asn Ala Val Leu Thr Leu Phe Asn Ile Tyr 
    210                 215                 220                 


Ser Thr Pro Leu Pro Tyr Ile Ser Gln Phe Gly Leu Tyr Thr Ser Leu 
225                 230                 235                 240 


Leu Ser Phe Ala Met Thr Phe Ile Ile Cys Ile Val Ser Arg Ser Asp 
                245                 250                 255     


Asn Thr Val Asp Pro Trp Pro Lys Ala Ser Asn Ile Phe Gly Ser Phe 
            260                 265                 270         


Asp Asn Gln Thr Gly Trp Asn Ser Ser Gly Met Ala Phe Val Val Gly 
        275                 280                 285             


Leu Val Asn Pro Ile Trp Ala Phe Val Gly Ile Asp Ser Ala Thr His 
    290                 295                 300                 


Met Ile Asp Glu Val Gly Tyr Ser Lys Ser Arg Phe Leu Val Pro Lys 
305                 310                 315                 320 


Val Ile Ile Thr Thr Ile Ile Val Gly Phe Val Thr Ser Phe Ile Tyr 
                325                 330                 335     


Cys Val Gly Leu Phe Phe Cys Ile Thr Asp Gln Thr Ala Val Val Glu 
            340                 345                 350         


Ser Ile Leu Pro Ile Val Glu Ile Phe Tyr Gln Ala Thr Gly Asn Arg 
        355                 360                 365             


Asn Leu Ser Val Phe Leu Gln Cys Met Cys Ile Thr Thr Gly Phe Val 
    370                 375                 380                 


Ser Gly Ile Ala Ser Gly Thr Trp Gln Ser Arg Ile Leu Gln Ser Phe 
385                 390                 395                 400 


Gly Lys Ser Tyr Ala Pro Phe Tyr Lys Glu Gly Ser Leu Gly Asn Lys 
                405                 410                 415     


Ser Leu Lys Lys Leu Ala Val Leu Thr Pro Gly Phe Lys Ser Pro Leu 
            420                 425                 430         


Tyr Ala His Phe Leu Ser Gln Ile Cys Val Thr Ile Ile Gly Cys Ile 
        435                 440                 445             


Phe Met Gly Ser Ser Thr Ala Phe Asn Ala Ile Ile Thr Ala Cys Ile 
    450                 455                 460                 


Thr Leu Leu Leu Met Ser Tyr Ala Val Pro Ser Phe Ile Phe Leu Phe 
465                 470                 475                 480 


Val Ile Lys Lys Glu Lys Phe Ile His Arg Ile Glu Ser Asp Val Asn 
                485                 490                 495     


Cys Val Ser Arg Pro Asn Arg Arg Arg Met Ser Met Ile Pro His Ile 
            500                 505                 510         


Ile Cys Ile Leu Trp Thr Leu Phe Cys Leu Val Phe Leu Ser Phe Pro 
        515                 520                 525             


Tyr Thr Leu Pro Val Thr Ala Gly Asn Met Asn Tyr Thr Ser Val Val 
    530                 535                 540                 


Tyr Ala Val Val Phe Cys Ile Ile Ser Ile Val Val Phe Pro Thr Cys 
545                 550                 555                 560 


Ile 
    


<210>  15
<211>  437
<212>  PRT
<213>  artificial

<220>
<223>  BIO6 protein

<400>  15

Met Leu Glu His Gln Leu Thr Gln Glu Asp Leu Glu Phe Asp Lys Lys 
1               5                   10                  15      


His Ile Trp His Pro Tyr Thr Ser Ile Thr Thr Pro Leu Lys Val Tyr 
            20                  25                  30          


Pro Ile Thr Lys Ala Glu Gly Ser Tyr Leu Tyr Leu Asp Asn Gly Thr 
        35                  40                  45              


Lys Val Val Asp Gly Met Ala Ser Trp Trp Cys Val Gln Gln Gly Tyr 
    50                  55                  60                  


Asn Asn His Arg Leu Asn Ala Ala Ala Ile Ser Gln Ile Asn Lys Met 
65                  70                  75                  80  


Ser His Val Met Phe Gly Gly Ile Thr His Lys Ala Gly Ile Asp Phe 
                85                  90                  95      


Cys Lys Lys Leu Leu Ala Leu Leu Pro Asp Thr Leu Glu Cys Ala Leu 
            100                 105                 110         


Leu Ala Asp Ser Gly Ser Ile Ser Val Asp Ile Ala Met Lys Met Ala 
        115                 120                 125             


Leu Arg Tyr His His Ser Leu Gly Asn Thr Thr Lys Lys Arg Phe Leu 
    130                 135                 140                 


Thr Ile Lys Lys Gly Tyr His Gly Asp Ala Phe Gly Ala Val Ser Val 
145                 150                 155                 160 


Cys Asp Pro Val Asn Ser Arg His Asn Thr Tyr Asn Gly Phe Leu Ala 
                165                 170                 175     


Glu Asn Ile Phe Cys Lys Ala Pro Glu Val Arg Phe Asp Cys Arg Glu 
            180                 185                 190         


Lys Asp Val Glu Lys Leu Val Glu Glu Leu Asp Val Lys Pro Phe Ala 
        195                 200                 205             


Glu Ile Ile Asp Lys His His Ser Glu Ile Ser Gly Val Val Met Glu 
    210                 215                 220                 


Ser Ile Val Gln Gly Ala Gly Gly Leu Arg Met Tyr His Pro Tyr Phe 
225                 230                 235                 240 


Leu Lys Arg Val Arg Ala Leu Cys Asn Asp Phe Asn Ile Leu Leu Ile 
                245                 250                 255     


Leu Asp Glu Val Ala Val Gly Leu Gly Arg Thr Gly Met Leu Phe Gly 
            260                 265                 270         


Phe Glu His Ala Gly Ile Val Pro Asp Ile Val Cys Leu Gly Lys Thr 
        275                 280                 285             


Leu Thr Ala Gly Tyr Leu Thr Leu Ser Ala Thr Val Thr Thr Arg Glu 
    290                 295                 300                 


Ile Gly Asp Gln Ile Ser Ser Gly Pro Glu Gly Cys Phe Met His Gly 
305                 310                 315                 320 


Gln Thr Tyr Met Ala Asn Pro Leu Ala Cys Ala Val Ala Ser Glu Asn 
                325                 330                 335     


Leu Ser Ile Leu Met Glu Gly Lys Trp Lys Ser Gln Val Arg Gln Ile 
            340                 345                 350         


Glu Val Gln Leu Lys Lys Glu Leu Val Pro Leu Leu Glu His Pro Ile 
        355                 360                 365             


Val Ala Asp Val Arg Ile Leu Gly Ala Ile Gly Val Val Glu Val Thr 
    370                 375                 380                 


Lys Arg Val Asn Val Glu Val Leu Gln Glu Lys Phe Ile Lys Ala Gly 
385                 390                 395                 400 


Ala Trp Ile Arg Pro Phe Gly Asn Ile Ile Tyr Ile Leu Pro Pro Tyr 
                405                 410                 415     


Ile Ile Thr Ser Glu Glu Leu Thr Val Leu Thr Glu Ala Ile Arg Ser 
            420                 425                 430         


Val Leu Asp Phe Ile 
        435         


