                         SEQUENCE LISTING

<110>  UCB Pharma S.A.
       LAWSON, Alastair
       NESBITT, Andrew       
       POPPLEWELL, Andrew
       SHAW, Stevan
       SHPEKTOR, Diana
       ZHANG, Yi
 
<120>  Antibody molecules having specificity for human OX40

<130>  G0088-WO01

<150>  US61/153038
<151>  2009-02-17

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1

<400>  1

Asn Tyr Gly Ile His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2

<400>  2

Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3

<400>  3

Gly Gly Glu Gly Ile Phe Asp Tyr 
1               5               


<210>  4
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL1

<400>  4

Arg Ala Thr Gln Ser Ile Tyr Asn Ala Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL2

<400>  5

Asn Ala Asn Thr Leu His Thr 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL3

<400>  6

Gln Gln Tyr Tyr Asp Tyr Pro Leu Thr 
1               5                   


<210>  7
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Light Chain variable region of antibody A26

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  8
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding Light chain variable region of antibody A26

<400>  8
gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgtc gtgcaaccca gagcatctac aacgctctgg cttggtatca gcagaaaccg      120

ggtaaagcgc caaaactcct gatctacaac gcgaacactc tgcataccgg tgttccgtct      180

cgtttctctg cgtctggttc tggtacggac tctactctga ccatctcctc tctgcagccg      240

gaagatttcg cgacctacta ctgccagcag tactacgatt acccactgac gtttggtggt      300

ggtaccaaag ttgagatcaa acgt                                             324


<210>  9
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable region of antibody A26

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding Heavy chain variable region of antibody A26

<400>  10
gaggttcagc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag caagcggttt cacgttcacc aactacggta tccactggat tcgtcaggca      120

ccaggtaaag gtctggaatg ggtagcctct atctctccgt ctggtggtct gacgtactac      180

cgtgactctg tcaaaggtcg tttcaccatc tctcgtgatg acgcgaaaaa ctctccgtac      240

ctgcagatga actctctgcg tgcagaagat accgcagtgt actactgcgc tactggtggt      300

gaaggtatct tcgactactg gggtcagggt accctggtaa ctgtctcgag c               351


<210>  11
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of antibody A26

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  12
<211>  235
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of antibody A26 including signal sequence

<400>  12

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln 
        35                  40                  45              


Ser Ile Tyr Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Tyr Asp Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  13
<211>  645
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding Light chain of antibody A26

<400>  13
gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgtc gtgcaaccca gagcatctac aacgctctgg cttggtatca gcagaaaccg      120

ggtaaagcgc caaaactcct gatctacaac gcgaacactc tgcataccgg tgttccgtct      180

cgtttctctg cgtctggttc tggtacggac tctactctga ccatctcctc tctgcagccg      240

gaagatttcg cgacctacta ctgccagcag tactacgatt acccactgac gtttggtggt      300

ggtaccaaag ttgagatcaa acgtacggtt gcagctccat ccgtcttcat ctttccaccg      360

tctgacgaac agctcaaatc tggtactgct tctgtcgttt gcctcctgaa caacttctat      420

ccgcgtgaag cgaaagtcca gtggaaagtc gacaacgcac tccagtctgg taactctcag      480

gaatctgtga ccgaacagga ctccaaagac tccacctact ctctgtctag caccctgact      540

ctgtccaaag cagactacga gaaacacaaa gtgtacgctt gcgaagttac ccatcagggt      600

ctgtcttctc cggttaccaa aagctttaat agaggggagt gttaa                      645


<210>  14
<211>  708
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding Light chain of antibody A26 including signal 
       sequence

<400>  14
atgaaaaaga cagctatcgc aattgcagtg gccttggctg gtttcgctac cgtagcgcaa       60

gctgatatcc agatgaccca gagtccaagc agtctctccg ccagcgtagg cgatcgtgtg      120

actattacct gtcgtgcaac ccagagcatc tacaacgctc tggcttggta tcagcagaaa      180

ccgggtaaag cgccaaaact cctgatctac aacgcgaaca ctctgcatac cggtgttccg      240

tctcgtttct ctgcgtctgg ttctggtacg gactctactc tgaccatctc ctctctgcag      300

ccggaagatt tcgcgaccta ctactgccag cagtactacg attacccact gacgtttggt      360

ggtggtacca aagttgagat caaacgtacg gttgcagctc catccgtctt catctttcca      420

ccgtctgacg aacagctcaa atctggtact gcttctgtcg tttgcctcct gaacaacttc      480

tatccgcgtg aagcgaaagt ccagtggaaa gtcgacaacg cactccagtc tggtaactct      540

caggaatctg tgaccgaaca ggactccaaa gactccacct actctctgtc tagcaccctg      600

actctgtcca aagcagacta cgagaaacac aaagtgtacg cttgcgaagt tacccatcag      660

ggtctgtctt ctccggttac caaaagcttt aatagagggg agtgttaa                   708


<210>  15
<211>  228
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of antibody A26

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Ala Ala 
225             


<210>  16
<211>  248
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of antibody A26 including signal sequence

<400>  16

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Thr Asn Tyr Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr 
65                  70                  75                  80  


Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                85                  90                  95      


Lys Asn Ser Pro Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Ala 
                245             


<210>  17
<211>  687
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding Heavy chain of antibody A26

<400>  17
gaggttcagc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag caagcggttt cacgttcacc aactacggta tccactggat tcgtcaggca      120

ccaggtaaag gtctggaatg ggtagcctct atctctccgt ctggtggtct gacgtactac      180

cgtgactctg tcaaaggtcg tttcaccatc tctcgtgatg acgcgaaaaa ctctccgtac      240

ctgcagatga actctctgcg tgcagaagat accgcagtgt actactgcgc tactggtggt      300

gaaggtatct tcgactactg gggtcagggt accctggtaa ctgtctcgag cgcttctacc      360

aaaggtccga gcgttttccc actggctccg agctctaaat ccacctctgg tggtacggct      420

gcactgggtt gcctggtgaa agactacttc ccagaaccag ttaccgtgtc ttggaactct      480

ggtgcactga cctctggtgt tcacaccttt ccagcagttc tgcagtcttc tggtctgtac      540

tccctgtcta gcgtggttac cgttccgtct tcttctctgg gtactcagac ctacatctgc      600

aacgtcaacc acaaaccgtc caacacgaaa gtggacaaaa aagtcgagcc gaaatcctgt      660

gacaaaaccc atacctgcgc tgcgtaa                                          687


<210>  18
<211>  750
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding Heavy chain of antibody A26 including signal 
       sequence

<400>  18
atgaagaaga ctgctatagc aattgcagtg gcgctagctg gtttcgccac cgtggcgcaa       60

gctgaggttc agctggtcga gtctggaggc gggcttgtcc agcctggagg gagcctgcgt      120

ctctcttgtg cagcaagcgg tttcacgttc accaactacg gtatccactg gattcgtcag      180

gcaccaggta aaggtctgga atgggtagcc tctatctctc cgtctggtgg tctgacgtac      240

taccgtgact ctgtcaaagg tcgtttcacc atctctcgtg atgacgcgaa aaactctccg      300

tacctgcaga tgaactctct gcgtgcagaa gataccgcag tgtactactg cgctactggt      360

ggtgaaggta tcttcgacta ctggggtcag ggtaccctgg taactgtctc gagcgcttct      420

accaaaggtc cgagcgtttt cccactggct ccgagctcta aatccacctc tggtggtacg      480

gctgcactgg gttgcctggt gaaagactac ttcccagaac cagttaccgt gtcttggaac      540

tctggtgcac tgacctctgg tgttcacacc tttccagcag ttctgcagtc ttctggtctg      600

tactccctgt ctagcgtggt taccgttccg tcttcttctc tgggtactca gacctacatc      660

tgcaacgtca accacaaacc gtccaacacg aaagtggaca aaaaagtcga gccgaaatcc      720

tgtgacaaaa cccatacctg cgctgcgtaa                                       750


<210>  19
<211>  1459
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding heavy and light chain of antibody A26 including 
       intergenic sequence IGS2

<400>  19
atgaaaaaga cagctatcgc aattgcagtg gccttggctg gtttcgctac cgtagcgcaa       60

gctgatatcc agatgaccca gagtccaagc agtctctccg ccagcgtagg cgatcgtgtg      120

actattacct gtcgtgcaac ccagagcatc tacaacgctc tggcttggta tcagcagaaa      180

ccgggtaaag cgccaaaact cctgatctac aacgcgaaca ctctgcatac cggtgttccg      240

tctcgtttct ctgcgtctgg ttctggtacg gactctactc tgaccatctc ctctctgcag      300

ccggaagatt tcgcgaccta ctactgccag cagtactacg attacccact gacgtttggt      360

ggtggtacca aagttgagat caaacgtacg gttgcagctc catccgtctt catctttcca      420

ccgtctgacg aacagctcaa atctggtact gcttctgtcg tttgcctcct gaacaacttc      480

tatccgcgtg aagcgaaagt ccagtggaaa gtcgacaacg cactccagtc tggtaactct      540

caggaatctg tgaccgaaca ggactccaaa gactccacct actctctgtc tagcaccctg      600

actctgtcca aagcagacta cgagaaacac aaagtgtacg cttgcgaagt tacccatcag      660

ggtctgtctt ctccggttac caaaagcttt aatagagggg agtgttaaaa tgaagaagac      720

tgctatagca attgcagtgg cgctagctgg tttcgccacc gtggcgcaag ctgaggttca      780

gctggtcgag tctggaggcg ggcttgtcca gcctggaggg agcctgcgtc tctcttgtgc      840

agcaagcggt ttcacgttca ccaactacgg tatccactgg attcgtcagg caccaggtaa      900

aggtctggaa tgggtagcct ctatctctcc gtctggtggt ctgacgtact accgtgactc      960

tgtcaaaggt cgtttcacca tctctcgtga tgacgcgaaa aactctccgt acctgcagat     1020

gaactctctg cgtgcagaag ataccgcagt gtactactgc gctactggtg gtgaaggtat     1080

cttcgactac tggggtcagg gtaccctggt aactgtctcg agcgcttcta ccaaaggtcc     1140

gagcgttttc ccactggctc cgagctctaa atccacctct ggtggtacgg ctgcactggg     1200

ttgcctggtg aaagactact tcccagaacc agttaccgtg tcttggaact ctggtgcact     1260

gacctctggt gttcacacct ttccagcagt tctgcagtct tctggtctgt actccctgtc     1320

tagcgtggtt accgttccgt cttcttctct gggtactcag acctacatct gcaacgtcaa     1380

ccacaaaccg tccaacacga aagtggacaa aaaagtcgag ccgaaatcct gtgacaaaac     1440

ccatacctgc gctgcgtaa                                                  1459


<210>  20
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2

<400>  20

Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL1

<400>  21

Arg Ala Thr Glu Asp Ile Tyr Asn Ala Leu Ala 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  human JH4

<400>  22

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  23
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  JK1 sequence

<400>  23

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


