
                                SEQUENCE LISTING

<110> Bianchi, Elisabetta
      Carrington, Paul E.
      Eiermann, George J.
      Ingallinella, Paolo
      Marsh, Donald J.
      Metzger, Joseph M.
      Pessi, Antonello
      Pocai, Alessandro
      Sinha Roy, Ranabir
      Dimarchi, Richard
      Ward, Brian
      
      

<120> OXYNTOMODULIN ANALOGS
  

<130> MRL-DOB-22547X

<150> PCT/US2009/034448   
<151> 2009-02-19  

<160> 121

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 2
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<400> 2
His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 3
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<400> 3
His Ser Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 4
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aminoisobutyric acid

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 4
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Cys
        35              


<210> 5
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(mPEG)5kDa

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 5
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 6
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(mPEG)20kDa

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 6
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 7
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(mPEG)2 40kDa

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 7
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 8
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(9cholest-5-en-3-yl{[(2R)-3-amino-2-(amino)
      -3-oxopropyl]thio}acetate)

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 8
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 9
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aminoisobutyric acid

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(mPEG)5kDa

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 9
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 10
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=aminoisobutyric acid

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(mPEG)20kDa

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 10
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 11
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> X=aminoisobutyric acid

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(mPEG)2 40kDa

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 11
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 12
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=aminoisobutyric acid

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(cholest-5-en-3-yl{[(2R)-3-amino-2-(amino)-
      3-oxopropyl]thio}acetate)

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 12
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 13
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=aminoisobutyric acid

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(mPEG)240kDa

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<221> MOD_RES        
<222> 27
<223> Xaa=methionine sulfoxide

<400> 13
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 14
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(mPEG)260kDa

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<221> MOD_RES        
<222> 27
<223> Xaa=methionine sulfoxide

<400> 14
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 15
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 20
<223> Xaa=Cys(mPEG)240kDa

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 15
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 16
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 21
<223> Xaa=Cys(mPEG)240kDa

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 16
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 17
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Aib

<221> MOD_RES        
<222> 24
<223> Xaa=Cys(mPEG)240kDa

<221> MOD_RES        
<222> 27
<223> Xaa=metionine sulfoxide

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 17
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 18
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 28
<223> Xaa=Cys(mPEG)240kDa

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 18
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 19
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 38
<223> Xaa=Lys(palmitoyl)

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 19
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 20
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 1
<223> Xaa=desamino-His (deltaNH2-H)

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 27
<223> Xaa=mrtionine sulfoxide

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(mPEG)240kDa

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 20
Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 21
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> xaa=D-serine

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol))

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 21
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 22
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 11
<223> Xaa=Cys(mPEG)240kDa

<221> MOD_RES        
<222> 27
<223> Xaa=methionine sulfoxide

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 22
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Xaa Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 23
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 12
<223> Xaa=Cys(mPEG)240kDa

<221> MOD_RES        
<222> 27
<223> Xaa=Methionine sulfoxide

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 23
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 24
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 38
<223> Xaa=Lys(palmitoyl)

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 24
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 25
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 27
<223> Xaa=Nle

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 25
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Cys
        35              


<210> 26
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 27
<223> Xaa=O-methyl-L-homoserine

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 26
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Cys
        35              


<210> 27
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 27
<223> Xaa=Nle

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(cholest-5-en-3-yl{[(2R)-3-amino-2-(amino)-
      3-oxopropyl]thio}acetate)

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 27
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 28
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(cholest-5-en-3-yl{[(2R)-3-amino-2-(amino)-
      3-oxopropyl]thio}acetate)

<221> MOD_RES        
<222> 27
<223> Xaa=O-methyl-L-homoserine

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 28
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 29
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol))

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 29
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 30
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 30
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Cys
        35              


<210> 31
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 27
<223> Xaa=metionine sulfoxide

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol))

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 31
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 32
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 27
<223> Xaa=methionine sulfoxide

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(CH2CONH2)

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 32
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 33
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=1-Amino-1-cyclohexane carboxylic acid

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 33
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 34
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Abu

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 34
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 35
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-abu

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 35
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 36
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Nva (Aminovaleric acid)

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 36
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 37
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa= beta-cyclopropyl-alanine

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 37
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 38
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=propargylglycine

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 38
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 39
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Allylglycine

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 39
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 40
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=2-Amino-2-cyclohexyl-propanoic acid

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 40
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 41
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-tertbutylglycine

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 41
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 42
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Vinylglycine

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 42
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 43
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=1-Amino-1-cyclopropane carboxylic acid

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 43
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 44
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=1-Amino-1-cyclobutane carboxylic acid

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 44
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 45
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=1-Amino-1-cyclopentane carboxylic acid

<221> AMIDATION      
<222> 37
<223> C-terminal amidation

<400> 45
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 46
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 46
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Cys
        35              


<210> 47
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 47
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Cys
            20                  25                  30      


<210> 48
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 48
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Cys
            20                  25                  30      


<210> 49
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 49
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Cys
            20                  25                  30      


<210> 50
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 50
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Cys
            20                  25                  30      


<210> 51
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol))

<221> AMIDATION      
<222> 38
<223> C-terminal amidation

<400> 51
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 52
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol))

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 52
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 53
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> X=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol))

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 53
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 54
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol))

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 54
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 55
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol))

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 55
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 56
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=Lys(Palmitoyl)

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 56
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 57
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=Lys(palmitoyl)

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 57
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 58
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=Ttds

<221> MOD_RES        
<222> 32
<223> Xaa=Lys(Palmitoyl)

<221> AMIDATION      
<222> 32
<223> C-terminal amidation

<400> 58
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 59
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=Ttds

<221> MOD_RES        
<222> 32
<223> Xaa=Lys(Palmitoyl)

<221> AMIDATION      
<222> 32
<223> C-terminal amidation

<400> 59
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 60
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 32
<223> Xaa=Cys(cholest-5-en-3-yl{[(2R)-3-amino-2-(amino)-
      3-oxopropyl]thio}acetate)

<221> AMIDATION      
<222> 32
<223> C-terminal amidation

<400> 60
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 61
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 32
<223> Xaa=Cys(cholest-5-en-3-yl{[(2R)-3-amino-2-(amino)-
      3-oxopropyl]thio}acetate)

<221> AMIDATION      
<222> 32
<223> C-terminal amidation

<400> 61
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 62
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 31
<223> Xaa= Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol))

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 62
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 63
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 38
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 39
<223> Xaa=Cys(cholest-5-en-3-yl{[(2R)-3-amino-2-(amino)-
      3-oxopropyl]thio}acetate)

<221> AMIDATION      
<222> 39
<223> C-terminal amidation

<400> 63
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa Xaa
        35                  


<210> 64
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 32
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol))

<221> AMIDATION      
<222> 32
<223> C-terminal amidation

<400> 64
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Xaa
            20                  25                  30          


<210> 65
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 38
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol))

<400> 65
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa
        35              


<210> 66
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 31
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol))

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 66
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 67
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 31
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 32
<223> Xaa=Cys(cholest-5-en-3-yl{[(2R)-3-amino-2-(amino)-
      3-oxopropyl]thio}acetate)

<400> 67
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 68
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 38
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 39
<223> Xaa=Lys(Palmitoyl)

<221> AMIDATION      
<222> 39
<223> C-terminal amidation

<400> 68
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Glu Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala Xaa Xaa
        35                  


<210> 69
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=Cys(cholest-5-en-3-yl{[(2R)-3-amino-2-(amino)-
      3-oxopropyl]thio}acetate)

<400> 69
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 70
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 32
<223> Xaa=Cys(cholest-5-en-3-yl
      1{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}acetate
      )

<400> 70
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ser Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 71
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 32
<223> Xaa=Cys(cholest-5-en-3-yl
      1{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}acetate
      );

<400> 71
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 72
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 32
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol)

<400> 72
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ser Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 73
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 32
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol)

<400> 73
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 74
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 32
<223> Xaa=Cys(cholest-5-en-3-yl
      1{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}acetate
      )

<400> 74
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 75
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 31
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 32
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol)

<400> 75
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 76
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol)

<400> 76
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 77
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=S-{1-[46-(cholest-5-en-3-yloxy)-3,43,46-trioxo
      -7,10,13,16,19,22,25,28,31,34,37,40-dodecaoxa-4,44
      -diazahexatetracont-1-yl]-2,5-dioxopyrrolidin-3-yl
      }-L-cysteine or Cys (mal-oxa12-cholesterol)

<400> 77
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 78
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa== Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol)

<400> 78
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 79
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=1-Amino-1-cyclobutane carboxylic acid

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=Cys(cholest-5-en-3-yl
      1-{[(2R)-3-amino-2-(amino)-3-oxopropyl]thio}-2-oxo
      -6,9,12,15-tetraoxa-3-azaoctadecan-18-oate]) or
      Cys(Oxa4-cholesterol)

<400> 79
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 80
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=S-[42-(cholest-5-en-3-yloxy)-2,42-dioxo-6,9,12
      ,15,18,21,24,27,30,33,36,39-dodecaoxa-3-azadotetra
      cont-1-yl]-L-cysteine or Cys (oxa12-cholesterol)

<223> Lactam bridge between side chains at positions 16
      and 20

<400> 80
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 81
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=S-[42-(cholest-5-en-3-yloxy)-2,42-dioxo-6,9,12
      ,15,18,21,24,27,30,33,36,39-dodecaoxa-3-azadotetra
      cont-1-yl]-L-cysteine or Cys (oxa12-cholesterol)

<223> Lactam bridge between the side chains at positions
      16 and 20

<400> 81
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 82
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=1-Amino-1-cyclobutane carboxylic acid

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=S-[42-(cholest-5-en-3-yloxy)-2,42-dioxo-6,9,12
      ,15,18,21,24,27,30,33,36,39-dodecaoxa-3-azadotetra
      cont-1-yl]-L-cysteine or Cys (oxa12-cholesterol)

<223> Lactam bridge bewteen the side chains at positions
      16 and 20

<400> 82
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 83
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=S-[42-(cholest-5-en-3-yloxy)-2,42-dioxo-6,9,12
      ,15,18,21,24,27,30,33,36,39-dodecaoxa-3-azadotetra
      cont-1-yl]-L-cysteine or Cys (oxa12-cholesterol)

<400> 83
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 84
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=S-[42-(cholest-5-en-3-yloxy)-2,42-dioxo-6,9,12
      ,15,18,21,24,27,30,33,36,39-dodecaoxa-3-azadotetra
      cont-1-yl]-L-cysteine or Cys (oxa12-cholesterol)

<400> 84
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 85
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=1-Amino-1-cyclobutane carboxylic acid

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=S-[42-(cholest-5-en-3-yloxy)-2,42-dioxo-6,9,12
      ,15,18,21,24,27,30,33,36,39-dodecaoxa-3-azadotetra
      cont-1-yl]-L-cysteine or Cys (oxa12-cholesterol)

<400> 85
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 86
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=Lys(gamma-glutamic acid-palmitoyl)

<221> AMIDATION      
<222> 33
<223> C-terminal amidation

<400> 86
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 87
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=S-[42-(cholest-5-en-3-yloxy)-2,42-dioxo-6,9,12
      ,15,18,21,24,27,30,33,36,39-dodecaoxa-3-azadotetra
      cont-1-yl]-L-cysteine or Cys (oxa12-cholesterol)

<221> AMIDATION      
<222> 33
<223> C-terminal amidation

<400> 87
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 88
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 20
<223> Xaa=Lys(gamma-glutamic acid-palmitoyl)

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> AMIDATION      
<222> 32
<223> C-terminal amidation

<400> 88
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 89
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 20
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-palmitoyl)

<221> MOD_RES        
<222> 31
<223> Xaa=gamma glutamic acid

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 89
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 90
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-palmitoyl)

<221> AMIDATION      
<222> 30
<223> C-terminal amidation

<400> 90
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys
            20                  25                  30  


<210> 91
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 20
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-palmitoyl)

<221> AMIDATION      
<222> 30
<223> C-terminal amidation

<400> 91
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr Lys
            20                  25                  30  


<210> 92
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-palmitoyl)

<221> AMIDATION      
<222> 30
<223> C-terminal amidation

<400> 92
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys
            20                  25                  30  


<210> 93
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=S-[78-(cholest-5-en-3-yloxy)-2,78-dioxo-6,9,12
      ,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,6
      3,66,69,72,75-tetracosaoxa-3-azaoctaheptacont-1-yl
      ]-L-cysteine or Cys (oxa24-cholesterol)

<400> 93
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 94
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=Aib

<221> MOD_RES        
<222> 24
<223> Xaa=Lys(DOTA)

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=S-[42-(cholest-5-en-3-yloxy)-2,42-dioxo-6,9,12
      ,15,18,21,24,27,30,33,36,39-dodecaoxa-3-azadotetra
      cont-1-yl]-L-cysteine or Cys (oxa12-cholesterol)

<221> AMIDATION      
<222> 33
<223> C-terminal amidation

<221> MOD_RES        
<222> (27)...(27)
<223> Xaa=methionine sulfoxide

<400> 94
His Xaa Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 95
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma glutamic acid-palmitoyl)

<221> MOD_RES        
<222> 31
<223> Xaa=gamma glutamic acid

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 95
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 96
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(palmitoyl)

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> AMIDATION      
<222> 32
<223> C-terminal amidation

<400> 96
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 97
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=aib

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma-glutamic acid-gamma glutamic
      acid-palmitoyl)

<221> AMIDATION      
<222> 30
<223> C-terminal amidation

<400> 97
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys
            20                  25                  30  


<210> 98
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=acb

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-palmitoyl

<221> AMIDATION      
<222> 30
<223> C-terminal amidation

<400> 98
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys
            20                  25                  30  


<210> 99
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> VARIANT        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-palmitoyl

<221> MOD_RES        
<222> 16
<223> Xaa=Aib

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 99
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Xaa
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 100
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=aib

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=Lys(gamma glutamic acid-palmitoyl)

<221> AMIDATION      
<222> 33
<223> C-terminal amidation

<400> 100
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 101
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=acb

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=Lys(gamma glutamic acid-palmitoyl)

<221> AMIDATION      
<222> 33
<223> C-terminal amidation

<400> 101
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 102
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> (31)...(32)
<223> Xaa=gamma glutamic acid

<221> MOD_RES        
<222> 33
<223> Xaa=S-[38-(cholest-5-en-3-yloxy)-2-oxo-6,9,12,15,1
      8,21,24,27,30,33,36-undecaoxa-3-azaoctatriacont-1-
      yl]-L-cysteine or Cys (oxa12-O-cholesterol)

<400> 102
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 103
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> VARIANT        
<222> 2
<223> Xaa=D-serine or Aib;

<221> VARIANT        
<222> 17
<223> Xaa=Arg or Glu

<221> VARIANT        
<222> 18
<223> Xaa=Arg or Ala

<221> VARIANT        
<222> 27
<223> Xaa=methionine, norleucine, or
      O-methyl-L-homoserine

<400> 103
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Xaa Xaa Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys
            20                  25                  30  


<210> 104
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM peptide

<400> 104
Arg Asn Arg Asn Asn Ile Ala
 1               5          


<210> 105
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> VARIANT        
<222> 2
<223> Xaa=D-serine; Aib; Acb; 1-Amino-1-cyclohexane
      carboxylic acid (Acx); alpha-aminobutyric
      acid(Abu); D- alpha-aminobutyric acid (D-Abu);
      Aminovaleric acid Nva); beta-cyclopropyl-alanine
      (Cpa); propargylglycine (Prg); Allylglycine (Alg);
      2-Amino-2-cyclohexyl-propanoic acid (2-Cha);
      D-tertbutylglycine (D-tbg); Vinylglycine (Vg);
      1-Amino-1-cyclopropane carboxylic acid (Acp); or
      1-Amino-1-cyclopentane carboxylic acid (Acpe)

<221> VARIANT        
<222> 17
<223> Xaa=Arg or Glu

<221> VARIANT        
<222> 18
<223> Xaa=Arg or Ala

<221> VARIANT        
<222> 27
<223> Xaa=methionine (M), norleucine (Nle), methionine
      sulfoxide (m) or O-methyl-L-homoserine (o)

<400> 105
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Xaa Xaa Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 106
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> VARIANT        
<222> 2
<223> Xaa=D-serine, alpha-aminoisobutyric acid (aib),
      1-Amino-1-cyclobutane carboxylic acid (Acb)
      residue, 1-Amino-1-cyclohexane carboxylic acid
      (Acx); alpha-aminobutyric acid(Abu); D-
      alpha-aminobutyric acid (D-Abu); Aminovaleric acid
      Nva); beta-cyclopropyl-alanine (Cpa);
      propargylglycine (Prg); Allylglycine (Alg);
      2-Amino-2-cyclohexyl-propanoic acid (2-Cha);
      D-tertbutylglycine (D-tbg); Vinylglycine (Vg);
      1-Amino-1-cyclopropane carboxylic acid (Acp); or
      1-Amino-1-cyclopentane carboxylic acid (Acpe)

<221> VARIANT        
<222> 12
<223> Xaa=Ser or Lys

<221> VARIANT        
<222> 16
<223> Xaa=Ser or Glu

<221> VARIANT        
<222> 17
<223> Xaa=Arg or Glu

<221> VARIANT        
<222> 18
<223> Xaa=Arg or Ala

<221> VARIANT        
<222> (20)...(20)
<223> Xaa=Gln or Lys

<221> VARIANT        
<222> (27)...(27)
<223> Xaa=a methionine, norleucine, methionine
      sulfoxide, or O-methyl-L-homoserine

<400> 106
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Xaa
 1               5                  10                  15      
Xaa Xaa Ala Xaa Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn
            20                  25                  30          
Arg Asn Asn Ile Ala
        35          


<210> 107
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> VARIANT        
<222> 2
<223> Xaa=D-serine, alpha-aminoisobutyric acid (aib),
      1-Amino-1-cyclobutane carboxylic acid (Acb)
      residue, 1-Amino-1-cyclohexane carboxylic acid
      (Acx); alpha-aminobutyric acid(Abu); D-
      alpha-aminobutyric acid (D-Abu); Aminovaleric acid
      Nva); beta-cyclopropyl-alanine (Cpa);
      propargylglycine (Prg); Allylglycine (Alg);
      2-Amino-2-cyclohexyl-propanoic acid (2-Cha);
      D-tertbutylglycine (D-tbg); Vinylglycine (Vg);
      1-Amino-1-cyclopropane carboxylic acid (Acp); or
      1-Amino-1-cyclopentane carboxylic acid (Acpe)

<221> VARIANT        
<222> 10
<223> Xaa=Tyr or Lys

<221> VARIANT        
<222> 12
<223> Xaa=Ser or Lys

<221> VARIANT        
<222> 16
<223> Xaa=Ser or Glu

<221> VARIANT        
<222> 17
<223> Xaa=Arg or Glu

<221> VARIANT        
<222> (18)...(18)
<223> Xaa=Arg or Ala

<221> VARIANT        
<222> (20)...(20)
<223> Xaa=Gln or Lys

<221> VARIANT        
<222> (27)...(27)
<223> Xaa=methionine, norleucine, methionine sulfoxide,
      or O-methyl-L-homoserine

<221> VARIANT        
<222> (31)...(31)
<223> Xaa=optional, but when present is one or more
      gamma glutamic acid residues

<400> 107
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Asp Xaa
 1               5                  10                  15      
Xaa Xaa Ala Xaa Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Xaa
            20                  25                  30      


<210> 108
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine, alpha-aminoisobutyric acid (aib),
      1-Amino-1-cyclobutane carboxylic acid (Acb)
      residue, 1-Amino-1-cyclohexane carboxylic acid
      (Acx); alpha-aminobutyric acid(Abu); D-
      alpha-aminobutyric acid (D-Abu); Aminovaleric acid
      Nva); beta-cyclopropyl-alanine (Cpa);
      propargylglycine (Prg); Allylglycine (Alg);
      2-Amino-2-cyclohexyl-propanoic acid (2-Cha);
      D-tertbutylglycine (D-tbg); Vinylglycine (Vg);
      1-Amino-1-cyclopropane carboxylic acid (Acp); or
      1-Amino-1-cyclopentane carboxylic acid (Acpe)

<221> MOD_RES        
<222> 10
<223> Xaa=Tyr or Lys

<221> MOD_RES        
<222> 12
<223> Xaa=Ser or Lys

<221> MOD_RES        
<222> 16
<223> Xaa=Ser or Lys

<221> MOD_RES        
<222> 17
<223> Xaa=Arg or Glu

<221> MOD_RES        
<222> (18)...(18)
<223> Xaa=Arg or Ala

<221> MOD_RES        
<222> (20)...(20)
<223> Xaa=Gln or Lys

<221> MOD_RES        
<222> (27)...(27)
<223> Xaa=methionine, norleucine, methionine sulfoxide,
      or O-methyl-L-homoserine

<221> MOD_RES        
<222> (31)...(31)
<223> optional, but when present one or more gamma
      glutamic acid residues

<400> 108
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Asp Xaa
 1               5                  10                  15      
Xaa Xaa Ala Xaa Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Xaa
            20                  25                  30      


<210> 109
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<400> 109
His Ser Gln Gly Thr Phe Thr Ser Asp Ser Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys
            20                  25                  30  


<210> 110
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine, ?-aminoisobutyric acid (aib),
      1-Amino-1-cyclobutane carboxylic acid (Acb)
      residue, 1-Amino-1-cyclohexane carboxylic acid
      (Acx); alpha-aminobutyric acid(Abu); D-
      alpha-aminobutyric acid (D-Abu); Aminovaleric acid
      Nva); beta-cyclopropyl-alanine (Cpa);
      propargylglycine (Prg); Allylglycine (Alg);
      2-Amino-2-cyclohexyl-propanoic acid (2-Cha);
      D-tertbutylglycine (D-tbg); Vinylglycine (Vg);
      1-Amino-1-cyclopropane carboxylic acid (Acp); or
      1-Amino-1-cyclopentane carboxylic acid (Acpe)
      residue

<221> MOD_RES        
<222> 10
<223> Xaa=Tyr or Lys

<221> MOD_RES        
<222> 12
<223> Xaa=Ser or Lys

<221> MOD_RES        
<222> 16
<223> Xaa=Ser, aib,  or Glu

<221> MOD_RES        
<222> 17
<223> Xaa=Arg or Glu

<221> MOD_RES        
<222> (18)...(18)
<223> Xaa=Arg or Ala

<221> MOD_RES        
<222> (20)...(20)
<223> Xaa=Glu or Lys

<221> MOD_RES        
<222> (27)...(27)
<223> Xaa=Met, norleucine, methionine sulfoxide, or
      O-methyl-L-homoserine

<221> MOD_RES        
<222> (31)...(31)
<223> Xaa=gamma-glutamic acid

<221> MOD_RES        
<222> (32)...(32)
<223> Xaa=is optional but when present, it is
      gamma-glutamic acid

<400> 110
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Asp Xaa
 1               5                  10                  15      
Xaa Xaa Ala Xaa Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Xaa Xaa
            20                  25                  30          


<210> 111
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-palmitoyl)

<221> MOD_RES        
<222> 16
<223> Xaa=Aib

<221> MOD_RES        
<222> 31
<223> Xaa=gamma-glutamic acid

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 111
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Xaa
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Xaa
            20                  25                  30      


<210> 112
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-palmitoyl)

<221> MOD_RES        
<222> 16
<223> Xaa=aib

<221> MOD_RES        
<222> 30
<223> Xaa=D-Lys

<221> MOD_RES        
<222> 31
<223> Xaa=gamma-glutamic acid

<221> AMIDATION      
<222> (31)...(31)
<223> C-terminal amidation

<400> 112
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Xaa
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa Xaa
            20                  25                  30      


<210> 113
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-palmitoyl)

<221> MOD_RES        
<222> 31
<223> Xaa=gamma-glutamic acid

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 113
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 114
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-palmitoyl)

<221> MOD_RES        
<222> 16
<223> Xaa=aib

<221> MOD_RES        
<222> 31
<223> Xaa=gamma-D-glutamic acid

<400> 114
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Xaa
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Xaa
            20                  25                  30      


<210> 115
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(glutamic acid-glutamic acid-palmitoyl)

<221> MOD_RES        
<222> 31
<223> Xaa=gamma-glutamic acid

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 115
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 116
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(Arg-Arg-palmitoyl)

<221> MOD_RES        
<222> 31
<223> Xaa=gamma-glutamic acid

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 116
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 117
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-Serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(homocysteic acid-homocysteic
      acid-palmitoyl)

<221> MOD_RES        
<222> 31
<223> Xaa=gamma-glutamic acid

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 117
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 118
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-Serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(D-glutamic acid-D-glutamic acid-palmitoyl)

<221> MOD_RES        
<222> 31
<223> Xaa=gamma-glutamic acid

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 118
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 119
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-Serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-myristoyl)

<221> MOD_RES        
<222> 16
<223> Xaa=aib

<221> MOD_RES        
<222> 31
<223> Xaa=gamma-glutamic acid

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 119
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Xaa
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      


<210> 120
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-Serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-palmitoyl)

<221> MOD_RES        
<222> 16
<223> Xaa=aib

<221> MOD_RES        
<222> 31
<223> Xaa=gamma-glutamic acid

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 120
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Xaa
 1               5                  10                  15      
Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Xaa
            20                  25                  30      


<210> 121
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> OXM analog

<221> MOD_RES        
<222> 2
<223> Xaa=D-Serine

<221> MOD_RES        
<222> 10
<223> Xaa=Lys(gamma-glutamic acid-gamma-glutamic
      acid-stearoyl)

<221> MOD_RES        
<222> 16
<223> Xaa=aib

<221> MOD_RES        
<222> 31
<223> Xaa=gamma-glutamic acid

<221> AMIDATION      
<222> 31
<223> C-terminal amidation

<400> 121
His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Xaa
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Xaa
            20                  25                  30      

