                         SEQUENCE LISTING

<110>  The Rockefeller University
       Friedman, Jeffrey
       Hedbacker, Kristina
 
<120>  Methods And Kits For Treating Disease By Administering IGFBP2

<130>  49248-85872

<150>  US 61/109,417
<151>  2008-10-29

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  1

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  2
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  3
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  3

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  4
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  5
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  5

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  6
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  7
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  7

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  8
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  9
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  9

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  10
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  11
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  11

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  12
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  13
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  13

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  14
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  15
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  15

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  16
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  17
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  17

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  18
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  19
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  19

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  20
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  21
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  21

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  22
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  23
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  23

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Cys 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  24
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Cys Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  25
<211>  329
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  25

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Cys Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln Leu 
                325                 


<210>  26
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Cys Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln Leu 
    290 


<210>  27
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(39)

<400>  27

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Arg Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val Asp Thr Gln Arg Met Gln 
                325             


<210>  28
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Arg Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val Asp Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  29
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  X can be any naturally occurring amino acid

<220>
<221>  SIGNAL
<222>  (1)..(39)

<220>
<221>  misc_feature
<222>  (137)..(137)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (139)..(139)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (323)..(323)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Xaa Arg Xaa Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val Xaa Thr Gln Arg Met Gln 
                325             


<210>  30
<211>  289
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  X can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (284)..(284)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Xaa Arg Xaa Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val Xaa Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


