                         SEQUENCE LISTING

<110>  SANOFI-AVENTIS
 
<120>  Use of Vgll3 activity modulator for the modulation of 
       adipogenesis

<130>  FR2008-129

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  3334
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(981)

<400>  1
atg agt tgt gcg gag gtg atg tat cac ccc cag ccg tat gga gcg ccc       48
Met Ser Cys Ala Glu Val Met Tyr His Pro Gln Pro Tyr Gly Ala Pro         
1               5                   10                  15              

cag tat ctg ccc aac cct gtg gca gct gca acc tgc cct aca gcc tgc       96
Gln Tyr Leu Pro Asn Pro Val Ala Ala Ala Thr Cys Pro Thr Ala Cys         
            20                  25                  30                  

tat cat ccg gct ccc caa cct ggc cag cag aag aag tta gcg gta tac      144
Tyr His Pro Ala Pro Gln Pro Gly Gln Gln Lys Lys Leu Ala Val Tyr         
        35                  40                  45                      

agc aag atg cag gac tct ctg gaa gtc acg ctt ccc agc aaa caa gag      192
Ser Lys Met Gln Asp Ser Leu Glu Val Thr Leu Pro Ser Lys Gln Glu         
    50                  55                  60                          

gag gag gag gag gag gag gag gat gag gag gag gag gag aaa gac cag      240
Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Lys Asp Gln         
65                  70                  75                  80          

cct gcc gag atg gag tac ctt aac tct cgc tgt gtc ctt ttc act tat      288
Pro Ala Glu Met Glu Tyr Leu Asn Ser Arg Cys Val Leu Phe Thr Tyr         
                85                  90                  95              

ttc cag gga gac att ggg tca gta gtg gat gaa cac ttc tca aga gct      336
Phe Gln Gly Asp Ile Gly Ser Val Val Asp Glu His Phe Ser Arg Ala         
            100                 105                 110                 

ttg ggc caa gcc aac acc ttg cat ccc gaa tct gcc att tca aaa agc      384
Leu Gly Gln Ala Asn Thr Leu His Pro Glu Ser Ala Ile Ser Lys Ser         
        115                 120                 125                     

aag atg ggg cta acc ccc cta tgg cga gac agc tca gct ctt tcg agc      432
Lys Met Gly Leu Thr Pro Leu Trp Arg Asp Ser Ser Ala Leu Ser Ser         
    130                 135                 140                         

cag cgg agt aat ttt cca act tcc ttt tgg acc agc tct tac caa ccc      480
Gln Arg Ser Asn Phe Pro Thr Ser Phe Trp Thr Ser Ser Tyr Gln Pro         
145                 150                 155                 160         

cca ccc gcg cct tgt ttg ggg gga gtt cat cct gac ttc caa gtc act      528
Pro Pro Ala Pro Cys Leu Gly Gly Val His Pro Asp Phe Gln Val Thr         
                165                 170                 175             

gca ccc cac ggc acc ttt act aca gca gat ccc aac tct tgg cca gga      576
Ala Pro His Gly Thr Phe Thr Thr Ala Asp Pro Asn Ser Trp Pro Gly         
            180                 185                 190                 

cat ggc ctg cat cag act ggc ccc gcc cca ccc ccc act gcg tct gag      624
His Gly Leu His Gln Thr Gly Pro Ala Pro Pro Pro Thr Ala Ser Glu         
        195                 200                 205                     

tct tgg cac tat cct ctg gca tct cag gtg agc ccg tcc tac agc cac      672
Ser Trp His Tyr Pro Leu Ala Ser Gln Val Ser Pro Ser Tyr Ser His         
    210                 215                 220                         

atg cat gac atg tac ctg cgc cat cat cac cct cac gct cac gtg cac      720
Met His Asp Met Tyr Leu Arg His His His Pro His Ala His Val His         
225                 230                 235                 240         

cat cgc cac cac cac cac cac cac cca act gct ggc tct gcc ttg gat      768
His Arg His His His His His His Pro Thr Ala Gly Ser Ala Leu Asp         
                245                 250                 255             

ccc gcc tat ggc cac ctg cta atg cca tca gtg cga gct gcc agg att      816
Pro Ala Tyr Gly His Leu Leu Met Pro Ser Val Arg Ala Ala Arg Ile         
            260                 265                 270                 

cct gct ccc cag tgc gac atc acc aag aca gat ctg act aca gtc acc      864
Pro Ala Pro Gln Cys Asp Ile Thr Lys Thr Asp Leu Thr Thr Val Thr         
        275                 280                 285                     

acg gct acc tca gca tgg gcc gga gcc ttt cat ggg aca gtg gac atc      912
Thr Ala Thr Ser Ala Trp Ala Gly Ala Phe His Gly Thr Val Asp Ile         
    290                 295                 300                         

gtg cca agt gtg ggc ttc gat aca ggt ctt cag cat cag gac aag agc      960
Val Pro Ser Val Gly Phe Asp Thr Gly Leu Gln His Gln Asp Lys Ser         
305                 310                 315                 320         

aaa gaa tca act tgg tac tga agcatggtat cagcagatca tatggcagca        1011
Lys Glu Ser Thr Trp Tyr                                                 
                325                                                     

tgaatccaag agcccactgg gaaaagatgc cattgggata tcccatccag aaatgggaca   1071

caggaaatgt ggagtgagaa gagaacatag aaggccattg tctttcgatt tgaacctttt   1131

ctggagaaaa catagagggc tctcctagtc cttgaggaag agcctttggg tttcttttcc   1191

ctcatctgag cctttgtcat ctgtgcaacg tcttgtttta cttgccttgt accagtacct   1251

gggctagctt ttgtatgcct ttttattttt ctttttgaac cagtaacctt gtaaaaagat   1311

gatctaccaa atgaaaatgc tcatttcttc aggaaaaact attaactcca tcttcatcta   1371

tttttataga aatacaaaat ggttggttta gcatggaggg gatatttttg aagatgtaat   1431

ttttttttta atgttgtaac agtcgttgag ttctgtttaa agaacttgct ctcagaaaag   1491

cactggccaa aatgctgaag cgctgatcca tctttagagt ctgtgatgcg ctgtgtctgt   1551

gcttccgagg gtacctcaag ggtttcatcc ttcctccaac agtggcactg ccgtagacaa   1611

accctgcaac attgtgttca tgttgaaact cagtgaagac ttaattcgat gatagctctc   1671

ttagtttgct gttatatatg tctgtgcatc ttgaaagggg cattttcctt taaagggaca   1731

caaagggaag gggacttctc cgaaatagtt cttggaggtt gactaacaag aaaaaaattg   1791

gttaatgaac aatacttctc tatatagtcc agcttatctt aacatttagg tggagagctt   1851

acacatggct tcaaaatagg gaaaaaaaaa tcaatgcatt tagccatgat aactgtggac   1911

atcacggctg aattttccta atttctaacc attcgttcat ggatgacttt ggatgactgt   1971

gttttctgaa tacaaatgag tagtatcagg aaaggaagga gacacgtgtc aaaatgctga   2031

ctgttcctca tctttgtaaa agtgatgtat tctttatgca atgttttcac ttgatcattt   2091

ttgcaagatt ttcatttgct tttaagtgta attagtttct aaaaaattag agcaaaataa   2151

aagtggtaat ggatttaagt ttatgcttca attacacaaa ctggttgaaa gactcaaagc   2211

ttgagaaatg aacttaacat ggcccacaag ataaaaaaaa tgaagttgga attaacttta   2271

agagaaaatt ggacaaagtt tgggattatg aaggtagcga tgagtggcaa gtcaaagaca   2331

caacctattt tttcctttta gttgctccca gccacacagg gcattagtgt agtatagatg   2391

cttttattta ataatgtttc tcaaattctt ccattcttct caggccacac aaaacagaag   2451

gttaagtcac gtgctatgtt ctgtttttaa ttgtgaactt catgggtgag aatattttac   2511

acattaacaa cacaacaagc agctacacag aattctcaca actcatttcc aaacatttca   2571

cttggctgta tcttagacat tcgtttctct tcctgctgtg ttttgaatta taaacccact   2631

tcatctcttg tagtcacaga ctcccatcat ttttttcatc ttgatttttc tttaacacag   2691

tcttcacatt tttatcaata taatctagac ttaaggaagc tcccactcac cagtttagga   2751

actttagcat ccagataatg ggcctcatta aattctgtgc atatttatct ggattttgat   2811

aacatataaa gttgttttat ttgttatctg tatctgcata aatatgtgga gcatagagtt   2871

gaatgaatct atcaaattca tgatgtcttg agtcttctta agttgtaaga attgagtact   2931

tagcaactct catgagggaa acactttggc tgttgtcaca tccttccttg agatatatta   2991

acttgcattg ccgtgtctct tagaacagta ccacacttcc aatcactgag ctcactccat   3051

taattttttc cagataaggg aggataagag gactaacttg ttttctttcc ttatttacca   3111

tcattctgga ttgaaaatga aagtagttaa tttcgtggtt ttgctgtgat atccttgtaa   3171

ctatggccaa aacatgattt ggttcaagat caaaggaaag tgaagaatct gaattctatt   3231

gcatgcaaca tgcaacatgc tctctcttta agaacaggca taggtatcag tggcacattg   3291

tcatcaaagg aggagaccaa aatctaataa aaggaaaaag aac                     3334


<210>  2
<211>  326
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ser Cys Ala Glu Val Met Tyr His Pro Gln Pro Tyr Gly Ala Pro 
1               5                   10                  15      


Gln Tyr Leu Pro Asn Pro Val Ala Ala Ala Thr Cys Pro Thr Ala Cys 
            20                  25                  30          


Tyr His Pro Ala Pro Gln Pro Gly Gln Gln Lys Lys Leu Ala Val Tyr 
        35                  40                  45              


Ser Lys Met Gln Asp Ser Leu Glu Val Thr Leu Pro Ser Lys Gln Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Lys Asp Gln 
65                  70                  75                  80  


Pro Ala Glu Met Glu Tyr Leu Asn Ser Arg Cys Val Leu Phe Thr Tyr 
                85                  90                  95      


Phe Gln Gly Asp Ile Gly Ser Val Val Asp Glu His Phe Ser Arg Ala 
            100                 105                 110         


Leu Gly Gln Ala Asn Thr Leu His Pro Glu Ser Ala Ile Ser Lys Ser 
        115                 120                 125             


Lys Met Gly Leu Thr Pro Leu Trp Arg Asp Ser Ser Ala Leu Ser Ser 
    130                 135                 140                 


Gln Arg Ser Asn Phe Pro Thr Ser Phe Trp Thr Ser Ser Tyr Gln Pro 
145                 150                 155                 160 


Pro Pro Ala Pro Cys Leu Gly Gly Val His Pro Asp Phe Gln Val Thr 
                165                 170                 175     


Ala Pro His Gly Thr Phe Thr Thr Ala Asp Pro Asn Ser Trp Pro Gly 
            180                 185                 190         


His Gly Leu His Gln Thr Gly Pro Ala Pro Pro Pro Thr Ala Ser Glu 
        195                 200                 205             


Ser Trp His Tyr Pro Leu Ala Ser Gln Val Ser Pro Ser Tyr Ser His 
    210                 215                 220                 


Met His Asp Met Tyr Leu Arg His His His Pro His Ala His Val His 
225                 230                 235                 240 


His Arg His His His His His His Pro Thr Ala Gly Ser Ala Leu Asp 
                245                 250                 255     


Pro Ala Tyr Gly His Leu Leu Met Pro Ser Val Arg Ala Ala Arg Ile 
            260                 265                 270         


Pro Ala Pro Gln Cys Asp Ile Thr Lys Thr Asp Leu Thr Thr Val Thr 
        275                 280                 285             


Thr Ala Thr Ser Ala Trp Ala Gly Ala Phe His Gly Thr Val Asp Ile 
    290                 295                 300                 


Val Pro Ser Val Gly Phe Asp Thr Gly Leu Gln His Gln Asp Lys Ser 
305                 310                 315                 320 


Lys Glu Ser Thr Trp Tyr 
                325     


<210>  3
<211>  10396
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (365)..(1345)

<400>  3
cgggcctggg ctgtggctgt gactggcgct gccgtgggcg ccgcagccct cgcgggagcc     60

ggacgcggta atgccccagc ggcgcagcgg gcggctgcgt ccctgagccg ctatataagc    120

gcggcaggga acatccggag gggctgaaga tgaaggtgcc cgcgcatggg cccccgctga    180

ttgccagtcc ctcccgaccc cgcgccccgc gcggagcccg aggccgccga ggacccgcct    240

tcgccgcagt agcagctgga gcagcgacag aggcggcagc tgcggcggcg gcggcgcccg    300

cgcccctcgc gccagcgcgt agagcggcgg cggcagctcg ggggccgcca ctgccccggc    360

tgcc atg agt tgt gcg gag gtg atg tat cac ccc cag cct tat gga gcg     409
     Met Ser Cys Ala Glu Val Met Tyr His Pro Gln Pro Tyr Gly Ala        
     1               5                   10                  15         

tcc cag tat ctg ccc aac ccc atg gca gcg aca acc tgc ccc aca gcc      457
Ser Gln Tyr Leu Pro Asn Pro Met Ala Ala Thr Thr Cys Pro Thr Ala         
                20                  25                  30              

tac tat cag ccg gcg ccc caa cct ggc cag cag aag aag tta gcg gta      505
Tyr Tyr Gln Pro Ala Pro Gln Pro Gly Gln Gln Lys Lys Leu Ala Val         
            35                  40                  45                  

ttc agc aag atg cag gac tct ctg gaa gtc acc ctt ccc agc aaa caa      553
Phe Ser Lys Met Gln Asp Ser Leu Glu Val Thr Leu Pro Ser Lys Gln         
        50                  55                  60                      

gag gag gag gat gag gag gag gag gag gag gag aaa gac cag cct gcc      601
Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Lys Asp Gln Pro Ala         
    65                  70                  75                          

gag atg gag tac ctt aac tct cgc tgt gtc ctt ttc act tat ttc cag      649
Glu Met Glu Tyr Leu Asn Ser Arg Cys Val Leu Phe Thr Tyr Phe Gln         
80                  85                  90                  95          

gga gac att ggg tca gta gtg gat gaa cac ttc tca aga gct ttg ggc      697
Gly Asp Ile Gly Ser Val Val Asp Glu His Phe Ser Arg Ala Leu Gly         
                100                 105                 110             

caa gcc atc acc ctc cat cca gaa tct gcc att tca aaa agc aag atg      745
Gln Ala Ile Thr Leu His Pro Glu Ser Ala Ile Ser Lys Ser Lys Met         
            115                 120                 125                 

ggg cta acc ccc cta tgg cga gac agc tca gct ctc tca agc cag cgg      793
Gly Leu Thr Pro Leu Trp Arg Asp Ser Ser Ala Leu Ser Ser Gln Arg         
        130                 135                 140                     

aat agt ttc cca act tcc ttt tgg acc agc tct tac cag ccc cca cct      841
Asn Ser Phe Pro Thr Ser Phe Trp Thr Ser Ser Tyr Gln Pro Pro Pro         
    145                 150                 155                         

gca cct tgt ttg ggg gga gtt cat cct gac ttc cag gtc act gga ccc      889
Ala Pro Cys Leu Gly Gly Val His Pro Asp Phe Gln Val Thr Gly Pro         
160                 165                 170                 175         

cct ggc acc ttt tct gca gct gat ccc agt cct tgg ccg gga cac aac      937
Pro Gly Thr Phe Ser Ala Ala Asp Pro Ser Pro Trp Pro Gly His Asn         
                180                 185                 190             

ctg cat cag act ggc cca gcc cct ccc cct gct gtg tct gag tcc tgg      985
Leu His Gln Thr Gly Pro Ala Pro Pro Pro Ala Val Ser Glu Ser Trp         
            195                 200                 205                 

cct tat cct ttg aca tct cag gtg agc cca tcc tac agc cat atg cat     1033
Pro Tyr Pro Leu Thr Ser Gln Val Ser Pro Ser Tyr Ser His Met His         
        210                 215                 220                     

gac gtg tac atg cgg cac cac cac cct cat gcc cac atg cac cac cgc     1081
Asp Val Tyr Met Arg His His His Pro His Ala His Met His His Arg         
    225                 230                 235                         

cac cgc cac cat cat cac cat cac cac cct cct gct ggc tct gcc ctg     1129
His Arg His His His His His His His Pro Pro Ala Gly Ser Ala Leu         
240                 245                 250                 255         

gat cca tcc tat ggg cct ctg ctg atg cct tca gtg cat gcg gcc agg     1177
Asp Pro Ser Tyr Gly Pro Leu Leu Met Pro Ser Val His Ala Ala Arg         
                260                 265                 270             

att cct gct ccc cag tgt gac atc aca aag aca gaa cca act aca gtc     1225
Ile Pro Ala Pro Gln Cys Asp Ile Thr Lys Thr Glu Pro Thr Thr Val         
            275                 280                 285                 

acc tct gct acc tca gca tgg gct gga gcc ttt cat gga aca gta gac     1273
Thr Ser Ala Thr Ser Ala Trp Ala Gly Ala Phe His Gly Thr Val Asp         
        290                 295                 300                     

ata gtg ccc agc gtg gga ttc gat aca ggt cta cag cat caa gac aag     1321
Ile Val Pro Ser Val Gly Phe Asp Thr Gly Leu Gln His Gln Asp Lys         
    305                 310                 315                         

agt aag gaa tca ccg tgg tac tga aacacacaat cttagtgagt taagttgcag    1375
Ser Lys Glu Ser Pro Trp Tyr                                             
320                 325                                                 

cataaatcca agggcccact gggaaaagat actgtcgggt ttttccattc agcaatagga   1435

cacgaaaggc atagaaggag aagacaaagt gtcacgcagt tgactggttt tcggcctttc   1495

ttgagaaagc aaagtgggtc ccagacattg aagaaaagca tttttatttg tttatttcct   1555

catctgagcc tttgccaact gtgcaactct ctccttttgt tatcttgctt ttatcaatat   1615

atagctaagt ttttgtttca ttttgatttt tttttttagc caaccacctt gtcaggaaag   1675

gatgaaccac acattaaaat gttcattctt tcaggaatac aagtttgtag ctctatgtgc   1735

atctattttt gtagaaatac aaaaagtttg gtttagcatt gatgggctat ttttgaggga   1795

tgtatttttt ttaaaattgt aaaaattgtt gagttctgtt taaagaactt gctctcagag   1855

aagcactggc aaaaatgttt aaaatgctta tctctaagat gtctattata tgctctgtct   1915

gtgctttcta ggttacctca aatgttttgt ttttttcctt cttacaaaag tagctatacc   1975

gtagtcaaac caatgcagta ttgtttttac attgaatctc agtaaagatt taattccatg   2035

ctagctcaat tagttttgaa ttatatgtat agcttgaaaa gttttttttt aatgactgtg   2095

ctaaagaaat gatattttat tgctttgatt tctcccaaag aataacttgg aggttgacta   2155

ataagaaagt tggcataaac tttcaatcaa atgaagagtt tgcctagagg agactaattc   2215

tctttctagc ccatccaaat ttgataaatg gaaccagagg ttatatacaa ctacaaggaa   2275

aaaaatgcat ttaaccatgc cacctatgag tgccagtgac ttattttact tgtttttaat   2335

tattcattca tggcaattta aaaagtcata ttttaagtgg gatttgtttt tcctgaaggg   2395

catttgaagg aacaatatct gggaaggtac tagagaaatt acaaagcccg agctctttct   2455

tataatgcca cctatccctg taagctaaac aaacaaacaa acaaacaaac aaacagttct   2515

atatataata gtttcaacac agaacttaac aagtctcttt ttttgtttgt ttaaatctgg   2575

ctttacttga tttaattcct ttttagaaag aaatttaggg caaaataaag tgtatattag   2635

gatttaaatt tatgccacaa tttaaaaata aaaccagagg ttatatacaa tttaaattgg   2695

gctaaaaatt aaaaatttga ggatttaact tgatatagct ctcaggatct aaataaagtt   2755

taaattatca ttaagacact gctaggagaa gattaagatt atgaaagtaa cagttattga   2815

tactgctgga cttcaaaggc aaagttcatt tcttccatta actgcttcca gagatgtcat   2875

gtaaaaaagt tagtgtatta gagaagtttt ttagctttat aaagaggttt tttcaaattt   2935

ctcccatttt tctctccacc cacataaaat agtatgttca gtgaaatgcc actttctatc   2995

tttaattgtt cgtatcatat atgcgaactt tttagacatg aacatgacat gttcagctag   3055

gcagagttct catagataat tttcaaatat tttccttggc tgtaatttat gtattcattt   3115

atatcctatc cgtcttttga gcttcagatc tatatactct tttgtactct catcactccg   3175

cactttgctg tttcttacct agactctctt ttacacaata tgcacatttt taccattgtg   3235

gggtccaaat ttaagatacc ttccactcac taataatatg aacttatatt tcctgggagt   3295

agccaggtta aattttctat actttggtcc ataatttgat ttgatatgat tgtttcattt   3355

ataatttgcc caaatacatg gagcacaaaa tttagtgaat ttataaatct ggatttgcct   3415

tgtgtccttc tgagttttca aaggcaagta ttcaacagtc cctgtgtgat gactgacagg   3475

gttatttgcc tcatccacat ccaccttcgg aatacattaa cttcctttgt aatttatttg   3535

aaagtagtgt taaactcatt cagatcattc agttggattt tcccaatgaa gaggaaaagg   3595

aaagtagtta ttcctagctc catttcttat tttccaccaa atttaattga agggcattaa   3655

ttagatgtct tcaccctgaa tttagacttt gctctgtgtt ctcccggtaa ctgtcagaca   3715

aaaagtttat tggctctgag gaactgagaa atgttgggaa cctggtttct gctgtacaca   3775

ggaaagattt gtaagtgagc tctctctttg aaaacaggac ccaggctggg cacagcagct   3835

catgcctgta atcctagtat tataggaggc agaggctcgg gaggattgct tgagcccagg   3895

agttcaagat cagcctaggc aacataggga gaccctatcc ctacaaaaaa tttctgaaaa   3955

attacctggg cattgtgggg cacacctgtt gtcccagcta ctctggaggc tgagtccgga   4015

ggaacgtttg agcctgggag tttgagtttg cagcttgcag tgagctgtga ttgcaccact   4075

gtactccagc ttgggcaaca gagcaagatc ctgtctcaaa aggaaaaaga aaacaggacc   4135

taggtgtttg gggtacactg ccacccaggg agtggatcaa aaatatacat agaaagagaa   4195

tgagcatgtc tctataattg tcttctagga ccatattgct gttagaagtc ctaaaagagg   4255

atgggttgta atttagcata atattctgaa ttcattccaa gtttaaaatc ctgtcattct   4315

ctggctcttc ttttttcaca tcaaaatgat gctgttggac ttagaggctt ccgaactgtt   4375

ttattgaggg ctactatctg cctccacaat tttattaaaa ccactccacc tttagacaaa   4435

ggtgactttt gtctgatttt acaaatcaga ttttattcaa gctttctaaa tatctgtgaa   4495

gtagacccta gaaaattgtc tcgtttattt taaatagaat ctatgcttcc accaataaac   4555

catcgggagc taagaaacaa cataatgttg acaaatcagg aacctaacag attattttgt   4615

ctctcattat taatttgaaa gagcctctaa acttttgaga aatcaatgtg tcttcttaag   4675

aaagttaagc accctctctt aactttcccc tctatttgct ctcctttttc tttcttctta   4735

agagtattta tattattttg ttaagcaaaa atggctaaga ttgctctaaa atttgcaaaa   4795

tgaggagtgg attgcaaata attgagggat ttatttcttt aactttataa gactttaaaa   4855

aaaaaaccca aattctaagc actgacatga aagttgcctt tgagaagctt gttattcatt   4915

atacaaaaag tatttgccca ttcctattct aagatttgca gaatatgtca ccctatctag   4975

cttttgagtt tgctatctgg tttaatgttg tatttataat ttaaagtgga aatcagaaac   5035

tgtttcaaga acctgtattc tattccttac tgagtgtccc ttctttaaat agtgtttgct   5095

gaattaagcc gatgggggca gtggcgttaa gtggtggaaa aaggaaagta tatatgttag   5155

agttttgaat gagggataaa tagaaagcag aatgaattaa tggaaaagaa ctcggctgtt   5215

aggccattct ctaaattcta gtttagccaa aagtttatgt gtggtttggg gcttcattta   5275

tttatctcat gagtaaaatg gaataatacc taacaggcag gctctggaag ttggaaatca   5335

catacacaca cacacacaca cagacacaca cacacacgat caatcatgta gctcatatta   5395

gatgttcaat aaataacagc tactacagat gcctatcagt tgagtaagta gttcattaaa   5455

ttgagctccc aaaggtctct tctcttcaca tccatatccg tttctgcagc aatcaaatag   5515

atacatgatt gtttttctgt aagaaattac tgcaaagaga atctttttct cctactaact   5575

gttccttcta cctggtatag gagataaatg tacgtttctt aattagctga ctttttagta   5635

tgtcatttct gaaggaaaaa taaattaacc ttaaagtggc atgtaggtcc aattcagttt   5695

tcctacatgt tccaaaattt tatttaaatt actgtgtcca aaattatgag gacagtgtca   5755

ttcattcacc atagtttata tttttagtta tatatcaaac ttccttggca cctaggataa   5815

gaacatttct tttgaagtta tccaattttt ttttattttt acttgacttg aaggaaagtt   5875

ggaaaatatg gtggaaaaaa tcttccgcat taaaaggggg aaaaacacaa ccatttacga   5935

tctcagtcag cagatttact ctactcaagg aaaaaaagaa acaatcttat tggaagcaga   5995

tgttgacact gtgtcagtta ttgaagacgg aaggagttca cttgagccat tgcagttaca   6055

aaggggtatt gatggcagtt tggattcctg attgatcacc tttgcagcca agggaaagac   6115

agcagaaact gtatgggatc agaaatgaaa tcagcctgcc agtttaatgg agaggctcct   6175

agaaactcat tttttttctt tcctgtaaga taaaagacat ctttcagaat aagaaaggct   6235

tgtttgagag agaaattaca gtttattctc tgaaaatatt taaaggccaa agtgcccttt   6295

aaatctatta ttaaagcatt gaaactgtta ttaaaatcat tatagaaaaa ttaggtaaaa   6355

attttagcct aactttcaac atccattcaa aaacgaatgt tgaaaacaaa catataacct   6415

ataaaaaagt gaatggctct ggcaagtggg ggcatgggtg gagtccataa ggaaacctca   6475

gtctcaataa cttcaaaatg ttacttttca tggtaacttg gtcatggaga ttggtcacag   6535

cacagacatt tagaattttt tagcaggttt tttttttctt ttgaatcttg tagtgctctc   6595

tgggaattgc accatgtaca cttttacaac ctacagaaat cgtcattatt gttaaagtat   6655

ctcaactttt ctatttcttt tattgtctat tgtgcttttt tgtttaaaaa tacttttata   6715

gttttaaagt attggtcaaa gtagtattct cttgaagttc tagtcaattt aatttgatcc   6775

aataagtttt tctgaatctc ctttttaagt tccaagaaat tctattataa ataagtgtac   6835

ttttaccaat tccattgtat aagcaaacag acacctttta gaaaaggata agtaatcatc   6895

aatttgtttt tttaaaaaaa aaaacaattt ctagactact aaatttggca taagaataat   6955

tcttttaaaa tgcaacatac tttaattagt ttttttggta tatgcataag atgtgaactt   7015

tcctattgat atcactttat attaatagag atgtacattt ctttctatgc cgtggctaga   7075

gcaaaagtta ataatgatta tttacacaat tgatttaatt tcttaggata tgtataatat   7135

tggatattat atctgattta aaaatactat tccatacatt ttttttttca ggagataaaa   7195

catagggaaa ggttttcatg tgaattcttt gtatcacttt gaagtacata tatttaaagg   7255

gaagatggat acaatttgtt tttattatat aaatctaggt aaggtgaaat gcttttgtca   7315

acaaaaatac agtgtagtga attttatatt tgtcacttga ttaggtaaac tgaaaactaa   7375

caatagaaat attattttac tgcattgaaa taccatgaac tttcagactt gttagttcta   7435

caagaagttg tgctacctta attttgtgtt tccagaaata aaaattaacc ttagttatgc   7495

tgtcattttt aactaataaa aaaagtataa ttcataaaac ttttggcttt ataagataat   7555

tataaaatta tatatttttt tctgtttttg tggggttggg aaaacatttt cttatttcta   7615

ttcactcttc aaatgcaggt ctcataatat gtgtcaatga tataagatga tggaagactt   7675

tgtaataaaa acatatgtca ttatcttcaa tttgttcaat aaataattta atgtgaattg   7735

aatgtttgta ttttaacata gcatttggat ttggtctgca tttcttgaga atttaaagct   7795

ctttttgttt cctccttatt caattaagca tcttataaat attttggaaa ttacaacatc   7855

ttaggtgtta ttaattaaga agttaatttc tagggccaag aagtctatat gttacagcaa   7915

ggaatagatt ataaaataca tgtttataat ggaaaagaaa atgaaatggg gtatattaat   7975

tacataacag caagagtctt gagaatttta taatacaatg cttctaagga tattggttga   8035

ccaaggtgta ttttattgtt tttacatttg ttgacaggga ctctgccata agtagtatga   8095

aaaaacaaac aaaaactttt ctacgattca ttaacattga aaagagaatt ccaagacctt   8155

gtattctgaa gaaagctaga gtttctctaa gtgggccttc aattttctta ttacacgtat   8215

ctttaatgtg aaagtactaa agtctgaaaa tcagcattta aataatagac tttccagcat   8275

tacagatgaa ataatttggc gcaggctttt taactgtcta ccatatttag aatgtggtgt   8335

caaaatgaga tttttagaac tgctgtaaaa tattactaca ttactacaac gataacggcc   8395

taaaacaaca caaatttatt atcttacagc tctgtcagtc agacattcag caaagatctt   8455

agtcttggtg ggctacagaa tgtaggaggc atttcctgga tgcttccaag agagaatctt   8515

gctgttccct gcttctagag tcctttgctt agtttccttc catcttcaaa tccagcaacc   8575

tggtcaagac cttctcacat gacatcactg acttcctctt cttcctctcc cttacatatt   8635

taaggactca tgtgattaca atagctgcat ctgtgtaatc cagaataatc tcttcatctc   8695

aaggtttttg ttctgttttg tttttttgtt ttgttttgtt ttgttttgtt ttgatggagt   8755

cttgctctgt cgtcaggctg gagtgcagtg gcgcgatctc ggctcactcc aacctccacc   8815

tcccgggttc aaaggattcc cctgcctcag cctctcgagt agctgggact acagatgcgt   8875

gctaccacac aaggctaata ttttgtattt tagtagagac gggatttcac catgttggcc   8935

aggatggtct ccgtctcctg acctcgtgat ctgcctgcct tggcctccca aagtgttggg   8995

attacaggca taagccattg cgccatgctc aaggttctta attacatctt taaaggccct   9055

ttttccatgt acagtaacat attcaatggt tctggggatt aggacttgga gccattattc   9115

tacctacaac aattagtatt ggacttccat cattttctat cactcttgta atcgagaagg   9175

actatttcac tgggagtagc aagtcataat gtttgcgttg gcatttgtgt gggggtttat   9235

cttcattcat taaataattg catgtaaaga aaattcctgt cactatttca aatgtttcat   9295

gtagttatta tagtgcttca gaatccaaag ggttatgtgt tacttatgta agatgagcag   9355

tctagggggt ggagaacagg tcatctagtg cagattcttc ctagctgaag tgtgttttct   9415

ctggggacaa ccaagtagga tttaattgtt ttgcttcctt ttttgggaac ttagacccat   9475

cttgcgatgt cctaagtctc caagcatctt atttgacctg cttatacaca tttgactaaa   9535

tagctaaata tgaccacatt gacgtggtaa agctttaaca cttttgtcca gattgaatca   9595

ctccatctgc tatcagttaa gcagtggaaa actgttatgg aaaagcaaac atgttttgat   9655

agatttaatg tgtaaagaag gtatccatac tctggaatgc tgctgatcaa taaatgagct   9715

gcaagacttt gttcgaaaca acactcaagc acaactgttt tactttccat accaagtttg   9775

gctgtgactg aatgaagaac atcagcattg atctttgctt tgcacttgta caagagacta   9835

tttgcagaga gccaaatata gcaacagagg atttaatatc ttgccaaaaa atacaaaatc   9895

tgttcccctt taagcatgac actctatcct ttcttgtgga tcttgctaaa aggaaaatat   9955

agctttaaac tcccctattc cttctgttga aagcttaaga atctttttca aatgagctat  10015

gtatggtttt gtggtatttt atgtttccaa aagaaaatgg ctacatgaaa aatctgtcca  10075

gtgttatcat ttttcttaca aaaaatactt ctagttatgg ttgtattaat taatttgatt  10135

gtgataatga ttacacaatg tttacctata tcaaatcatc atatcgtata ccttaaatat  10195

atataacttt tatgtgtcaa ttataactca gtaagtctgg gaaaatatcg ttaagtcaaa  10255

gattagagtc aacagaaata aagaaaaatc atactttgat aacttcagga ctaatcaagg  10315

atcaatgggt gacatgatat catgctatgt gccattttgt gttaaacaaa ttacaccaac  10375

aataaaaaaa attggcttca a                                            10396


<210>  4
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Cys Ala Glu Val Met Tyr His Pro Gln Pro Tyr Gly Ala Ser 
1               5                   10                  15      


Gln Tyr Leu Pro Asn Pro Met Ala Ala Thr Thr Cys Pro Thr Ala Tyr 
            20                  25                  30          


Tyr Gln Pro Ala Pro Gln Pro Gly Gln Gln Lys Lys Leu Ala Val Phe 
        35                  40                  45              


Ser Lys Met Gln Asp Ser Leu Glu Val Thr Leu Pro Ser Lys Gln Glu 
    50                  55                  60                  


Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Lys Asp Gln Pro Ala Glu 
65                  70                  75                  80  


Met Glu Tyr Leu Asn Ser Arg Cys Val Leu Phe Thr Tyr Phe Gln Gly 
                85                  90                  95      


Asp Ile Gly Ser Val Val Asp Glu His Phe Ser Arg Ala Leu Gly Gln 
            100                 105                 110         


Ala Ile Thr Leu His Pro Glu Ser Ala Ile Ser Lys Ser Lys Met Gly 
        115                 120                 125             


Leu Thr Pro Leu Trp Arg Asp Ser Ser Ala Leu Ser Ser Gln Arg Asn 
    130                 135                 140                 


Ser Phe Pro Thr Ser Phe Trp Thr Ser Ser Tyr Gln Pro Pro Pro Ala 
145                 150                 155                 160 


Pro Cys Leu Gly Gly Val His Pro Asp Phe Gln Val Thr Gly Pro Pro 
                165                 170                 175     


Gly Thr Phe Ser Ala Ala Asp Pro Ser Pro Trp Pro Gly His Asn Leu 
            180                 185                 190         


His Gln Thr Gly Pro Ala Pro Pro Pro Ala Val Ser Glu Ser Trp Pro 
        195                 200                 205             


Tyr Pro Leu Thr Ser Gln Val Ser Pro Ser Tyr Ser His Met His Asp 
    210                 215                 220                 


Val Tyr Met Arg His His His Pro His Ala His Met His His Arg His 
225                 230                 235                 240 


Arg His His His His His His His Pro Pro Ala Gly Ser Ala Leu Asp 
                245                 250                 255     


Pro Ser Tyr Gly Pro Leu Leu Met Pro Ser Val His Ala Ala Arg Ile 
            260                 265                 270         


Pro Ala Pro Gln Cys Asp Ile Thr Lys Thr Glu Pro Thr Thr Val Thr 
        275                 280                 285             


Ser Ala Thr Ser Ala Trp Ala Gly Ala Phe His Gly Thr Val Asp Ile 
    290                 295                 300                 


Val Pro Ser Val Gly Phe Asp Thr Gly Leu Gln His Gln Asp Lys Ser 
305                 310                 315                 320 


Lys Glu Ser Pro Trp Tyr 
                325     


<210>  5
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer VgII3-F

<400>  5
ggccacacaa aacagaaggt taag                                            24


<210>  6
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Primer VgII3-R

<400>  6
tcacccatga agttcacaat taaaa                                           25


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer hVgII3-F

<400>  7
tccccctgct gtgtctgagt                                                 20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer hVgII3-R

<400>  8
ggatgggctc acctgagatc                                                 20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Cyclophilin A-F

<400>  9
ttttgacttg cgggcatttt                                                 20


<210>  10
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Cyclophilin A-R

<400>  10
ggacgctctc ctgagctaca ga                                              22


<210>  11
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer hCyclophilin A-F

<400>  11
ttcatctgca ctgccaagac                                                 20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer hCyclophilin A-R

<400>  12
tcgagttgtc cacagtcagc                                                 20


<210>  13
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Ap2-F

<400>  13
ccgcagacga caggaaggt                                                  19


<210>  14
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Ap2-R

<400>  14
agggccccgc catct                                                      15


<210>  15
<211>  2491
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (377)..(1339)

<400>  15
ggctgcccga cccgggcctg ggctgtggct gtgactggcg ctgccgtggg cgccgcagcc     60

ctcgcgggag ccggacgcgg taatgcccca gcggcgcagc gggcggctgc gtccctgagc    120

cgctatataa gcgcggcagg gaacatccgg aggggctgaa gatgaaggtg cccgcgcatg    180

ggcccccgct gattgccagt ccctcccgac cccgcgcccc gcgcggagcc cgaggccgcc    240

gaggacccgc cttcgccgca gtagcagctg gagcagcgac agaggcggca gctgcggcgg    300

cggcggcgcc cgcgcccctc gcgccagcgc gtagagcggc ggcggcagct cgggggccgc    360

cactgccccg gctgcc atg agt tgt gcg gag gtg atg tat cac ccc cag cct    412
                  Met Ser Cys Ala Glu Val Met Tyr His Pro Gln Pro       
                  1               5                   10                

tat gga gcg tcc cag tat ctg ccc aac ccc atg gca gcg aca acc tgc      460
Tyr Gly Ala Ser Gln Tyr Leu Pro Asn Pro Met Ala Ala Thr Thr Cys         
        15                  20                  25                      

ccc aca gcc tac tat cag ccg gcg ccc caa cct ggc cag cag aag aag      508
Pro Thr Ala Tyr Tyr Gln Pro Ala Pro Gln Pro Gly Gln Gln Lys Lys         
    30                  35                  40                          

tta gcg gta ttc agc aag atg cag gac tct ctg gaa gtc acc ctt ccc      556
Leu Ala Val Phe Ser Lys Met Gln Asp Ser Leu Glu Val Thr Leu Pro         
45                  50                  55                  60          

agc aaa caa gag gag gag gat gag gag gag gag gag gag gag aaa gac      604
Ser Lys Gln Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Lys Asp         
                65                  70                  75              

cag cct gcc gag atg gag tac ctt aac tct cgc tgt gtc ctt ttc act      652
Gln Pro Ala Glu Met Glu Tyr Leu Asn Ser Arg Cys Val Leu Phe Thr         
            80                  85                  90                  

tat ttc cag gga gac att ggg tca gta gtg gat gaa cac ttc tca aga      700
Tyr Phe Gln Gly Asp Ile Gly Ser Val Val Asp Glu His Phe Ser Arg         
        95                  100                 105                     

gct ttg ggc caa gcc atc acc ctc cat cca gaa tct gcc att tca aaa      748
Ala Leu Gly Gln Ala Ile Thr Leu His Pro Glu Ser Ala Ile Ser Lys         
    110                 115                 120                         

agc aag atg ggg cta acc ccc cta tgg cga gac agc tca gct ctc tca      796
Ser Lys Met Gly Leu Thr Pro Leu Trp Arg Asp Ser Ser Ala Leu Ser         
125                 130                 135                 140         

agc cag cgg aat agt ttc cca act tcc ttt tgg acc agc tct tac cag      844
Ser Gln Arg Asn Ser Phe Pro Thr Ser Phe Trp Thr Ser Ser Tyr Gln         
                145                 150                 155             

ccc cca cct gca cct tgt ttg ggg gga gtt cat cct gac ttc cag gtc      892
Pro Pro Pro Ala Pro Cys Leu Gly Gly Val His Pro Asp Phe Gln Val         
            160                 165                 170                 

act gga ccc cct ggc acc ttt tct gca gct gat ccc agt cct tgg ccg      940
Thr Gly Pro Pro Gly Thr Phe Ser Ala Ala Asp Pro Ser Pro Trp Pro         
        175                 180                 185                     

gga cac aac ctg cat cag act ggc cca gcc cct ccc cct gct gtg tct      988
Gly His Asn Leu His Gln Thr Gly Pro Ala Pro Pro Pro Ala Val Ser         
    190                 195                 200                         

gag tcc tgg cct tat cct ttg aca tct cag gtg agc cca tcc tac agc     1036
Glu Ser Trp Pro Tyr Pro Leu Thr Ser Gln Val Ser Pro Ser Tyr Ser         
205                 210                 215                 220         

cat atg cat gac gtg tac atg cgg cac cac cac cct cat gcc cac atg     1084
His Met His Asp Val Tyr Met Arg His His His Pro His Ala His Met         
                225                 230                 235             

cac cac cgc cac cgc cac cat cat cac cat cac cac cct cct gct ggc     1132
His His Arg His Arg His His His His His His His Pro Pro Ala Gly         
            240                 245                 250                 

tct gcc ctg gat cca tcc tat ggg cct ctg ctg atg cct tca gtg cat     1180
Ser Ala Leu Asp Pro Ser Tyr Gly Pro Leu Leu Met Pro Ser Val His         
        255                 260                 265                     

gcg gcc agg att cct gct ccc cag tgt gac atc aca aag aca gaa cca     1228
Ala Ala Arg Ile Pro Ala Pro Gln Cys Asp Ile Thr Lys Thr Glu Pro         
    270                 275                 280                         

act aca gtc acc tct gct acc tca gca tgg gct gga gcc ttt cat gga     1276
Thr Thr Val Thr Ser Ala Thr Ser Ala Trp Ala Gly Ala Phe His Gly         
285                 290                 295                 300         

aca gta gac ata gtg ccc agc gtg gga ttc gat aca ggc tgg agt gca     1324
Thr Val Asp Ile Val Pro Ser Val Gly Phe Asp Thr Gly Trp Ser Ala         
                305                 310                 315             

atg gcg aga tct tga ctcactgcaa cctctgcctc ccgagttcaa ccaattgtcc     1379
Met Ala Arg Ser                                                         
            320                                                         

tgcctcagcc acctgagtag ctggaattac aggcatctgc caccacgccc ggctaatttt   1439

ttgtattttt agtagatagt cactattttg aatagtgaag gctggcttcc ctattttgaa   1499

tagtgaaggc tggcttccct attttgaata gtgaaggctg gcttccctat tttggccagg   1559

ctggtctcaa actcctgacc tcgtgatcca cctgcctcgg actcccaagg tgctgggatt   1619

acaggtgtga gccactgtgt ccagccctca tgtacaaatt tttaagtaaa tgtgtgttta   1679

attctcttgg aaatatatct aggagtagaa ctgtggggtt aagagaacct cactttttat   1739

tttatgtatt tctatatttt ttgaattttt ttcaaagagc atatatatgc aatttttaaa   1799

atatttaaat ttaaattttt gttttttaaa ttttttttta gtatttaaat tgttaagatt   1859

cattacaaca tattatagta gagtttgagg tttggtaggc aaaactgcca taggaatgaa   1919

gtaaggtggt ccattttttc cgaagggctg agtggtggtg aggacagtga ggtgcctctg   1979

gcacaaaatt taaaaggatc catactgtga gggctgtgca agtgtatgcc accccatatt   2039

ttgcacccag ggctccttat tcctctaacc tctgtcttgg tgttgctttg ctgtcatgcg   2099

agctcactct tactttttgc tccctctgtt gaacaggtat tacatacagg taccttgaaa   2159

tgatcagtat ggtatgatca taagtcattt gtatttgccc tccacgtgaa aaatgctcat   2219

ctttaccaag aggctgttat cacaaatctc acattaggct ttttcccttt cctttatcag   2279

tctttaaact gagtttcatg ggttccatag gaaaaatact cagaatgtga taataagggc   2339

ttaattgaaa aaagaaaaga tctattatca aatgaattta tttacattgc ctaccatata   2399

cctcttagag atcacagttc cctatagcat ataaaatgtt ttatatattc ttcagtaaaa   2459

aagcatttta aattgtaaaa aaaaaaaaaa aa                                 2491


<210>  16
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Cys Ala Glu Val Met Tyr His Pro Gln Pro Tyr Gly Ala Ser 
1               5                   10                  15      


Gln Tyr Leu Pro Asn Pro Met Ala Ala Thr Thr Cys Pro Thr Ala Tyr 
            20                  25                  30          


Tyr Gln Pro Ala Pro Gln Pro Gly Gln Gln Lys Lys Leu Ala Val Phe 
        35                  40                  45              


Ser Lys Met Gln Asp Ser Leu Glu Val Thr Leu Pro Ser Lys Gln Glu 
    50                  55                  60                  


Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Lys Asp Gln Pro Ala Glu 
65                  70                  75                  80  


Met Glu Tyr Leu Asn Ser Arg Cys Val Leu Phe Thr Tyr Phe Gln Gly 
                85                  90                  95      


Asp Ile Gly Ser Val Val Asp Glu His Phe Ser Arg Ala Leu Gly Gln 
            100                 105                 110         


Ala Ile Thr Leu His Pro Glu Ser Ala Ile Ser Lys Ser Lys Met Gly 
        115                 120                 125             


Leu Thr Pro Leu Trp Arg Asp Ser Ser Ala Leu Ser Ser Gln Arg Asn 
    130                 135                 140                 


Ser Phe Pro Thr Ser Phe Trp Thr Ser Ser Tyr Gln Pro Pro Pro Ala 
145                 150                 155                 160 


Pro Cys Leu Gly Gly Val His Pro Asp Phe Gln Val Thr Gly Pro Pro 
                165                 170                 175     


Gly Thr Phe Ser Ala Ala Asp Pro Ser Pro Trp Pro Gly His Asn Leu 
            180                 185                 190         


His Gln Thr Gly Pro Ala Pro Pro Pro Ala Val Ser Glu Ser Trp Pro 
        195                 200                 205             


Tyr Pro Leu Thr Ser Gln Val Ser Pro Ser Tyr Ser His Met His Asp 
    210                 215                 220                 


Val Tyr Met Arg His His His Pro His Ala His Met His His Arg His 
225                 230                 235                 240 


Arg His His His His His His His Pro Pro Ala Gly Ser Ala Leu Asp 
                245                 250                 255     


Pro Ser Tyr Gly Pro Leu Leu Met Pro Ser Val His Ala Ala Arg Ile 
            260                 265                 270         


Pro Ala Pro Gln Cys Asp Ile Thr Lys Thr Glu Pro Thr Thr Val Thr 
        275                 280                 285             


Ser Ala Thr Ser Ala Trp Ala Gly Ala Phe His Gly Thr Val Asp Ile 
    290                 295                 300                 


Val Pro Ser Val Gly Phe Asp Thr Gly Trp Ser Ala Met Ala Arg Ser 
305                 310                 315                 320 


<210>  17
<211>  2000
<212>  DNA
<213>  Homo sapiens


<220>
<221>  promoter
<222>  (1)..(2000)

<400>  17
atctgcatta gtgtgctagg gctgtcataa ataccacaaa ctaggtggcc taaaaaaaca     60

aattaagctg ggcataccgt ggctcacgcc tgtaatccca gtactttggg aggccgaggt    120

gggcggatca cctgaagtca ggagttcaag atcatcctgg ccaacatggt gaaaccctgt    180

ctctacaaaa gtacaaaaat tagccgggca tgatggcggg tgcctgtaat cccagctact    240

cgggaggctg gggcggaaga atcacttgaa ccgggaggag gttgcagtga gccgagatcg    300

tgacattgca ctccagcctg ggcaacagag cgatactccg tctcaaaaaa aaaaaaaaaa    360

aaaaaaagtt aattttttca tagttctgga ggatagaagc acaagataag gtgtggtcag    420

tgttggtttc aaggtgagac ctttcttctt ggcttgtagg taactcacta tgacttcaga    480

tggtctttcc tctttgacag agcagagaga cagggagtgg ggtttggggg agacatagat    540

atctctggcg tgttttctct tcttataagg aacctagtcc tattagatta gggcccaacc    600

ttttaaatct catttaacct tatcacctcc ttatatgtcc tgtcttcaaa tacagccata    660

ttgtgggtta gggcttcaat atatacattt ttgggaagac ataattcaaa ctataaaaac    720

attagtgcat ttgactttca aactgacttt ttctctgaga aaagatagac tgtaaaaatg    780

agagattgct gtgagtcata aaagaggatg cctacgtata aggagagata tgtttgctga    840

atctcagagc tagagtttgc tcatttataa aatgaggccc agtgcggtgc ctcatgcctg    900

ttatcccagc actttgggag accgaggcag aaggatcact tgaggccagg agttggagac    960

cagcctaggt aacatagcaa gaccccttct ctataaaaaa aaaaattaaa aaaattacct   1020

gggcgtggta atgcacgcct gtagtcccag ctactccaga ggctgagatg ggaggatctc   1080

ttgagcgtgg gggtggtagc tgcagtgagc tgtgctcatg tcactgtact ctagcttggg   1140

cggcagaagg aaaccctatc tcaaaataaa taaaataatg tgagtataat tatttctact   1200

gattatgtca gaatacaagt atattctcac agacgttttt ttccccattt tggagagggt   1260

cagatccaat tgcaaagaga taaaccttta ttagcgaatg ggcttaatca actacccttt   1320

attgctctgt gaaaaccagg ctgtaaaagc cagaaatggt ggacgtctca cagcagtgtc   1380

ataccatgaa gatgtaaact taaagcagag attgcttgtg gaaaactgtg ttgcattctt   1440

ggcatgtggg cacttgcaga gatgttaact ttcacttatg attattttaa tgtaggagct   1500

aatccccgtg tattctgcgc ctgctctgtt ttaccccttt gtacactcgg cttttgtttg   1560

gtcccagcct ctgagttggt gttccctgta aaatctcctt ggagtaggga agccctcgcc   1620

ctggcggcca ggtgacagag acagggtggg aacctgccga gccttgaggg cgcggagcct   1680

ctgcatacca ttcccctccc accaccatcc catgctggga ggcggagagg gctgcaaact   1740

tcgctccaat ccgcagccag ccttccccgg ggtccccctg cagggtgacc cgcccgctgc   1800

aaagcgagtt ggagaaactt tgcaaagttc cgcgtcagag cctggggagg caaagtgctc   1860

ccccttctcc ccggcgttcc ccctccctct gcccccgcct ccctgtcctc gcacagccgg   1920

gagcacccgt gataggacga gccccgggcg tgcattgtgt atatgcaaac cggagctggg   1980

ctccccacgg ctgcccgacc                                               2000


<210>  18
<211>  1957
<212>  DNA
<213>  Mus sp.


<220>
<221>  promoter
<222>  (1)..(1957)

<400>  18
cattctctct ctctctctct ctctctctct ctctctctct ctctctctct ctctgtctcc     60

cctccctccc tctctccctc cctctctccc tccctccttc tctccatctc ccccttctgt    120

ctcaaaaaaa gaaacaacaa caacaaaata caacaaacaa gacacaagta agataaaaaa    180

aattccagaa caaaacaaaa agcccaccag aagcacagtg tctgtgttgt tagccaagta    240

cttcttcctg gtcatgtggc ttgccctgta atgtggttga gagaccgagt gactacactg    300

gagaaagtgg atttctcctt tgccaacaga taacaaaaat actttaaagg tctatcctgt    360

cagttttaat tcataactga tctgaagtaa agaaaaataa taaacctggt ttaaaaaaat    420

gatacgaaac ctactccaat tctattcttt aaccttgtat tggcaaattt cagtctttaa    480

acttatgtat aaaataagaa cccatgttac ttatgtgttt ttattatatg ttttaatatc    540

aggtttcata actcatctga gttcttcagt cccaagacta gtcaggttga acagtccatt    600

ttatgtgaca aatttgttta aatatcacca tgaaacacac cagttacttg gactgaagca    660

gggtccttta aaaatgtcag gaagaaaagt gacttttatg ttttatcgtt atttgaaaat    720

ggtacaaagt tcgccaaact ttcttcacat aaaagcagtt taaaaaatta gaacattggc    780

aacagcctat ggagtgaaaa gaaaatgggt ttcagtgaaa ataaagtgcc ccagtgttct    840

agggtggccc agaagctccc gaagcgagag tggctcacag tatatcatcc tcacagagct    900

aacacacttc ttggttgata atcatttata attgcatcgc agttcttttc agttgttaca    960

gggtttcctc tccacacaac ctttggataa ttgctttcaa ttttctacaa ttagtatttt   1020

ttttaaaaca ttttaaaagg aatctacatc aatatttacc ataggctttc tatttttttg   1080

gggggggggt tgttggtttt tcgagacaga gtttctctgt gtagccctgg ctgtcctgga   1140

actcactttg tagaccaggc tggcctcgaa ctcagaaatc cacctgcctc tgcctcccga   1200

gtgctgggat taaaggcgag cgccaccatg cccggctacc ataggctttc ttacagaagg   1260

tattctaaat tagacaagct catatttttt aatcaacctt gaaggacaac ttttttgaaa   1320

tatgacagaa agtgcagact ccacaaagac ggttcaaaca cttccagtat agattaagag   1380

cctgcagaaa tcccatactc taccactgca tcattataga taaataaatc tcttgtgcac   1440

ccggatctta taaagtctat caaaatagaa ctgctgatta ttttaaactt gaaagtcatg   1500

tcccaattat tattttacac ttctgttttt aatatcttca tcaagctctc tcttactttt   1560

ccccattaac cttttgtttt tctcctccct ggtgcttgtc caggttgctg cttcatttaa   1620

agttctcagc ccgttgttga ctcctgaacc atctgtgaca gacaccatcg cactgtcagc   1680

cagctgcact gaagtgtgac agcattgctt tccttcctgc aattaggttt ttctctctta   1740

aagagttaag ggcatttgct gtttatctat gctggggtga ttgtaaggac caggtcgatt   1800

tagctgtcag tgaactaaaa catttataaa tagcacagga taaaagaatg ttacagtttt   1860

attttatttc ggtcacctta aagacaaata tcaattgcag tcacctgcag tcacatctgc   1920

tttgctcctg aggatgaggg ctagtaactg cagggct                            1957


