                         SEQUENCE LISTING

<110>  Biofocus DPI BV
       Glaxo Group Ltd
       Janssen, Richard AJ
       De Groot, Anton
       Lekkerkerker, Annemarie N
       Meldrum, Eric C
       Thompson, Nicola
 
<120>  METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS 
       AND TREATMENT OF DISEASES INVOLVING INFLAMMATION

<130>  GAL-P1066PCT

<150>  US 61/208,267
<151>  2009-02-19

<160>  86    

<170>  PatentIn version 3.5

<210>  1
<211>  2067
<212>  DNA
<213>  Homo sapiens

<400>  1
aagacctgga gtacctcgga gctgcgacct ccagttcaca ataccacctg cctcacaccc       60

gggctcatct tttcatccca cacccaccac ccccctctcc gttcacggtg tcccgggagg      120

ctgcgacctg cgtagatgat ttagcagact gcccctgccc atgctcctgc tcctgctcct      180

cctcctcctc ttccccgctc tctccctctc gcctcctctt ccagtccagg cgcccagact      240

cggcgaagcg cagcgcctgc caccagcggt gcctcgggct gcccggcgcg ccgcgctccc      300

aggttctgtc tcgccgcacc ccggcgggca ctggcgcggg caaggacgct ggcggggaga      360

acgccctggg ctcaacgtac tccagaatcg aatgttgaga gaagcagtgc tctgatccag      420

ctcaggagaa aaaggagcgg gttccgagtg agacttctgg agccagctgg acgtgccggt      480

ttgcccagtg cggcgcggct gcacgcaccg tccacaagga accttcactc agaagaaatg      540

ctgtggccct tccctttacc aacagaaaat ggaacacaag agaccacata gctgaacaaa      600

ttatagcctc cttacaagtg agaaaccttc gaggctacat agttttcagc caaaggaaaa      660

taaccaacag cttctccaca gtgtagactg aaacaaggga aacatgaaca tcacaaactg      720

taccacagag gccagcatgg ctataagacc caagaccatc actgagaaga tgctcatttg      780

catgactctg gtggtcatca ccaccctcac cacgttgctg aacttggctg tgatcatggc      840

tattggcacc accaagaagc tccaccagcc tgccaactac ctaatctgtt ctctggccgt      900

gacggacctc ctggtggcag tgctcgtcat gcccctgagc atcatctaca ttgtcatgga      960

tcgctggaag cttgggtact tcctctgtga ggtgtggctg agtgtggaca tgacctgctg     1020

cacctgctcc atcctccacc tctgtgtcat tgccctggac aggtactggg ccatcaccaa     1080

tgctattgaa tacgccagga agaggacggc caagagggcc gcgctgatga tccttaccgt     1140

ctggaccatc tccattttca tctccatgcc ccctctgttc tggagaagcc accgccgcct     1200

aagccctccc cctagtcagt gcaccatcca gcacgaccat gttatctaca ccatttactc     1260

cacgctgggt gcgttttata tccccttgac tttgatactg attctctatt accggattta     1320

ccacgcggcc aagagccttt accagaaaag gggatcaagt cggcacttaa gcaacagaag     1380

cacagatagc cagaattctt ttgcaagttg taaacttaca cagactttct gtgtgtctga     1440

cttctccacc tcagacccta ccacagagtt tgaaaagttc catgcctcca tcaggatccc     1500

ccccttcgac aatgatctag atcacccagg agaacgtcag cagatctcta gcaccaggga     1560

acggaaggca gcacgcatcc tggggctgat tctgggtgca ttcattttat cctggctgcc     1620

atttttcatc aaagagttga ttgtgggtct gagcatctac accgtgtcct cggaagtggc     1680

cgactttctg acgtggctcg gttatgtgaa ttctctgatc aaccctctgc tctatacgag     1740

ttttaatgaa gactttaagc tggcttttaa aaagctcatt agatgccgag agcatactta     1800

gactgtaaaa agctaaaagg cacgactttt tccagagcct catgagtgga tgggggtaag     1860

gggtgcaact tattaattct tgaacatact tggttcagga gagtttgtaa gtatgtgtgg     1920

tcttgtttcc ttgtttgttt gtttgttttg ttctgttttg tttgaggatt gttatttggc     1980

gtgctgtttt ctacctctgg tcttatctgt gatacataat ttcaaataaa cattatcata     2040

caaaaacaaa aaaaaaaaaa aaaaaaa                                         2067


<210>  2
<211>  2357
<212>  DNA
<213>  Homo sapiens

<400>  2
ggctcgcccg ggggccatgg cagcagcggc tactgcagcc gagggggtcc ccagtcgggg       60

gcctcccggg gaagtcatcc atctgaatgt gggaggcaag agattcagta cctctcgcca      120

gactctcacc tggatcccag actccttctt ctccagtctt ctgagcggac gcatctcgac      180

gctgaaagat gagaccggag caatcttcat cgacagggac cctacagtct tcgcccccat      240

cctcaacttc ctgcgcacca aagagttgga tcccaggggt gtccacggtt ccagcctcct      300

ccatgaagcc cagttctatg ggctcactcc tctggttcgt cgcctgcagc ttcgagagga      360

gttggatcga tcttcttgtg gaaacgtcct cttcaatggt tacctgccgc caccagtgtt      420

cccagtgaag cggcggaacc ggcacagcct agtggggcct cagcagctag gaggacggcc      480

agcccctgtc cgacggagca acacgatgcc ccccaacctt ggcaatgcag ggctgctggg      540

ccgaatgctg gatgagaaaa cccctccctc accctcagga caacctgagg agccggggat      600

ggtgcgcctg gtgtgtggac accataattg gatcgctgtg gcctataccc agtttctagt      660

ctgctacagg ttgaaggaag cctctggctg gcagctggtg ttttccagcc cccgcctgga      720

ctggcccatc gaacgactgg cgctcacagc ccgggtgcat ggtggggctt tgggtgaaca      780

tgacaagatg gtggcagcag ccaccggcag cgagatcctg ctatgggctc tgcaggcgga      840

aggcggtggc tccgagatag gggtctttca tctgggggtg cctgtggagg ccttgttctt      900

cgtcgggaac cagctcattg ctacaagcca cacagggcgc atcggggtgt ggaatgccgt      960

caccaagcac tggcaggtcc aggaggtgca gcccatcacc agttatgacg cggcaggctc     1020

cttcctcctc ctgggctgca acaacggctc catttactac gtggatgtgc agaagttccc     1080

cttgcgcatg aaagacaacg acctccttgt cagcgagctc tatcgggacc cagcggagga     1140

tggggtcacc gccctcagtg tctacctcac ccccaagacc agtgacagtg ggaactggat     1200

cgagatcgcc tatggcacca gctcaggggg cgtgcgggtc atcgtgcagc acccggagac     1260

tgtgggctcg gggcctcagc tcttccagac cttcactgtg caccgcagcc ctgtcaccaa     1320

gatcatgctg tcggagaagc acctcatctc agtctgtgcc gacaacaacc acgtgcggac     1380

atggtctgtg actcgcttcc gcggcatgat ttccacccag cccggctcca ccccactcgc     1440

ttcctttaag atcctggctc tggagtcggc agatgggcat ggcggctgca gtgctggcaa     1500

tgacattggc ccctacggtg agcgggacga ccagctagtg ttcatccaga aggtggtgcc     1560

cagtgccagc cagctcttcg tgcgtctctc atctactggg cagcgggtgt gctccgtgcg     1620

ctccgtggac ggctcaccca cgacggcctt cacagtgctg gagtgcgagg gctcccggcg     1680

gctcggctct cggccccggc gctacctgct cactggccag gccaacggca gcttggccat     1740

gtgggaccta accaccgcca tggacggcct cggccaggcc cctgcaggtg gcctgacgga     1800

gcaagagctg atggaacagc tggaacactg tgagctggcc ccgccggctc cttcagctcc     1860

ctcatggggc tgtctcccca gcccctcacc ccgcatctcc ctcaccagcc tccactcagc     1920

ctccagcaac acctccttgt ctggccaccg tgggagccca agccccccgc aggctgaggc     1980

ccggcgccgt ggtgggggca gctttgtgga acgctgccag gaactggtgc ggagtgggcc     2040

agacctccga cggccaccca caccagcccc gtggccctcc agcggtctcg gcactcccct     2100

cacacctccc aagatgaagc tcaatgaaac ttccttttga acaacgcagc tgccatgatg     2160

ccttgggatg ccctggtcct gggggactca ggtgcctccc tgattcctgt gggaaccccg     2220

ggttcagggc cagggcctcc ttggaataaa tggttattgt tactaggtcc ccaccttccc     2280

tcttttctgg aagccaaagt cagcctcccc aataaagtcc tcactgccta aaaaaaaaaa     2340

aaaaaaaaaa aaaaaaa                                                    2357


<210>  3
<211>  2560
<212>  DNA
<213>  Homo sapiens

<400>  3
ctcaaaaggg gccggatttc cttctcctgg aggcagatgt tgcctctctc tctcgctcgg       60

attggttcag tgcactctag aaacactgct gtggtggaga aactggaccc caggtctgga      120

gcgaattcca gcctgcaggg ctgataagcg aggcattagt gagattgaga gagactttac      180

cccgccgtgg tggttggagg gcgcgcagta gagcagcagc acaggcgcgg gtcccgggag      240

gccggctctg ctcgcgccga gatgtggaat ctccttcacg aaaccgactc ggctgtggcc      300

accgcgcgcc gcccgcgctg gctgtgcgct ggggcgctgg tgctggcggg tggcttcttt      360

ctcctcggct tcctcttcgg gtggtttata aaatcctcca atgaagctac taacattact      420

ccaaagcata atatgaaagc atttttggat gaattgaaag ctgagaacat caagaagttc      480

ttatataatt ttacacagat accacattta gcaggaacag aacaaaactt tcagcttgca      540

aagcaaattc aatcccagtg gaaagaattt ggcctggatt ctgttgagct agcacattat      600

gatgtcctgt tgtcctaccc aaataagact catcccaact acatctcaat aattaatgaa      660

gatggaaatg agattttcaa cacatcatta tttgaaccac ctcctccagg atatgaaaat      720

gtttcggata ttgtaccacc tttcagtgct ttctctcctc aaggaatgcc agagggcgat      780

ctagtgtatg ttaactatgc acgaactgaa gacttcttta aattggaacg ggacatgaaa      840

atcaattgct ctgggaaaat tgtaattgcc agatatggga aagttttcag aggaaataag      900

gttaaaaatg cccagctggc aggggccaaa ggagtcattc tctactccga ccctgctgac      960

tactttgctc ctggggtgaa gtcctatcca gatggttgga atcttcctgg aggtggtgtc     1020

cagcgtggaa atatcctaaa tctgaatggt gcaggagacc ctctcacacc aggttaccca     1080

gcaaatgaat atgcttatag gcgtggaatt gcagaggctg ttggtcttcc aagtattcct     1140

gttcatccaa ttggatacta tgatgcacag aagctcctag aaaaaatggg tggctcagca     1200

ccaccagata gcagctggag aggaagtctc aaagtgccct acaatgttgg acctggcttt     1260

actggaaact tttctacaca aaaagtcaag atgcacatcc actctaccaa tgaagtgaca     1320

agaatttaca atgtgatagg tactctcaga ggagcagtgg aaccagacag atatgtcatt     1380

ctgggaggtc accgggactc atgggtgttt ggtggtattg accctcagag tggagcagct     1440

gttgttcatg aaattgtgag gagctttgga acactgaaaa aggaagggtg gagacctaga     1500

agaacaattt tgtttgcaag ctgggatgca gaagaatttg gtcttcttgg ttctactgag     1560

tgggcagagg agaattcaag actccttcaa gagcgtggcg tggcttatat taatgctgac     1620

tcatctatag aaggaaacta cactctgaga gttgattgta caccgctgat gtacagcttg     1680

gtacacaacc taacaaaaga gctgaaaagc cctgatgaag gctttgaagg caaatctctt     1740

tatgaaagtt ggactaaaaa aagtccttcc ccagagttca gtggcatgcc caggataagc     1800

aaattgggat ctggaaatga ttttgaggtg ttcttccaac gacttggaat tgcttcaggc     1860

agagcacggt atactaaaaa ttgggaaaca aacaaattca gcggctatcc actgtatcac     1920

agtgtctatg aaacatatga gttggtggaa aagttttatg atccaatgtt taaatatcac     1980

ctcactgtgg cccaggttcg aggagggatg gtgtttgagc tagccaattc catagtgctc     2040

ccttttgatt gtcgagatta tgctgtagtt ttaagaaagt atgctgacaa aatctacagt     2100

atttctatga aacatccaca ggaaatgaag acatacagtg tatcatttga ttcacttttt     2160

tctgcagtaa agaattttac agaaattgct tccaagttca gtgagagact ccaggacttt     2220

gacaaaagca agcatgtcat ctatgctcca agcagccaca acaagtatgc aggggagtca     2280

ttcccaggaa tttatgatgc tctgtttgat attgaaagca aagtggaccc ttccaaggcc     2340

tggggagaag tgaagagaca gatttatgtt gcagccttca cagtgcaggc agctgcagag     2400

actttgagtg aagtagccta agaggattct ttagagaatc cgtattgaat ttgtgtggta     2460

tgtcactcag aaagaatcgt aatgggtata ttgataaatt ttaaaattgg tatatttgaa     2520

ataaagttga atattatata taaaaaaaaa aaaaaaaaaa                           2560


<210>  4
<211>  2653
<212>  DNA
<213>  Homo sapiens

<400>  4
ctcaaaaggg gccggatttc cttctcctgg aggcagatgt tgcctctctc tctcgctcgg       60

attggttcag tgcactctag aaacactgct gtggtggaga aactggaccc caggtctgga      120

gcgaattcca gcctgcaggg ctgataagcg aggcattagt gagattgaga gagactttac      180

cccgccgtgg tggttggagg gcgcgcagta gagcagcagc acaggcgcgg gtcccgggag      240

gccggctctg ctcgcgccga gatgtggaat ctccttcacg aaaccgactc ggctgtggcc      300

accgcgcgcc gcccgcgctg gctgtgcgct ggggcgctgg tgctggcggg tggcttcttt      360

ctcctcggct tcctcttcgg gtggtttata aaatcctcca atgaagctac taacattact      420

ccaaagcata atatgaaagc atttttggat gaattgaaag ctgagaacat caagaagttc      480

ttatataatt ttacacagat accacattta gcaggaacag aacaaaactt tcagcttgca      540

aagcaaattc aatcccagtg gaaagaattt ggcctggatt ctgttgagct agcacattat      600

gatgtcctgt tgtcctaccc aaataagact catcccaact acatctcaat aattaatgaa      660

gatggaaatg agattttcaa cacatcatta tttgaaccac ctcctccagg atatgaaaat      720

gtttcggata ttgtaccacc tttcagtgct ttctctcctc aaggaatgcc agagggcgat      780

ctagtgtatg ttaactatgc acgaactgaa gacttcttta aattggaacg ggacatgaaa      840

atcaattgct ctgggaaaat tgtaattgcc agatatggga aagttttcag aggaaataag      900

gttaaaaatg cccagctggc aggggccaaa ggagtcattc tctactccga ccctgctgac      960

tactttgctc ctggggtgaa gtcctatcca gatggttgga atcttcctgg aggtggtgtc     1020

cagcgtggaa atatcctaaa tctgaatggt gcaggagacc ctctcacacc aggttaccca     1080

gcaaatgaat atgcttatag gcgtggaatt gcagaggctg ttggtcttcc aagtattcct     1140

gttcatccaa ttggatacta tgatgcacag aagctcctag aaaaaatggg tggctcagca     1200

ccaccagata gcagctggag aggaagtctc aaagtgccct acaatgttgg acctggcttt     1260

actggaaact tttctacaca aaaagtcaag atgcacatcc actctaccaa tgaagtgaca     1320

agaatttaca atgtgatagg tactctcaga ggagcagtgg aaccagacag atatgtcatt     1380

ctgggaggtc accgggactc atgggtgttt ggtggtattg accctcagag tggagcagct     1440

gttgttcatg aaattgtgag gagctttgga acactgaaaa aggaagggtg gagacctaga     1500

agaacaattt tgtttgcaag ctgggatgca gaagaatttg gtcttcttgg ttctactgag     1560

tgggcagagg agaattcaag actccttcaa gagcgtggcg tggcttatat taatgctgac     1620

tcatctatag aaggaaacta cactctgaga gttgattgta caccgctgat gtacagcttg     1680

gtacacaacc taacaaaaga gctgaaaagc cctgatgaag gctttgaagg caaatctctt     1740

tatgaaagtt ggactaaaaa aagtccttcc ccagagttca gtggcatgcc caggataagc     1800

aaattgggat ctggaaatga ttttgaggtg ttcttccaac gacttggaat tgcttcaggc     1860

agagcacggt atactaaaaa ttgggaaaca aacaaattca gcggctatcc actgtatcac     1920

agtgtctatg aaacatatga gttggtggaa aagttttatg atccaatgtt taaatatcac     1980

ctcactgtgg cccaggttcg aggagggatg gtgtttgagc tagccaattc catagtgctc     2040

ccttttgatt gtcgagatta tgctgtagtt ttaagaaagt atgctgacaa aatctacagt     2100

atttctatga aacatccaca ggaaatgaag acatacagtg tatcatttga ttcacttttt     2160

tctgcagtaa agaattttac agaaattgct tccaagttca gtgagagact ccaggacttt     2220

gacaaaagca acccaatagt attaagaatg atgaatgatc aactcatgtt tctggaaaga     2280

gcatttattg atccattagg gttaccagac aggccttttt ataggcatgt catctatgct     2340

ccaagcagcc acaacaagta tgcaggggag tcattcccag gaatttatga tgctctgttt     2400

gatattgaaa gcaaagtgga cccttccaag gcctggggag aagtgaagag acagatttat     2460

gttgcagcct tcacagtgca ggcagctgca gagactttga gtgaagtagc ctaagaggat     2520

tctttagaga atccgtattg aatttgtgtg gtatgtcact cagaaagaat cgtaatgggt     2580

atattgataa attttaaaat tggtatattt gaaataaagt tgaatattat atataaaaaa     2640

aaaaaaaaaa aaa                                                        2653


<210>  5
<211>  1992
<212>  DNA
<213>  Homo sapiens

<400>  5
agcaaatact cactaccaca aataagaaca tttccaaatc tgatgttctg aggattttta       60

gagcttatag tagcaaaaag aaaagggaaa ttctctctga gatgtccttt tttgtaggcc      120

taatgacaaa aggttgaaga taaagttcta gtactcattt aagtgtaata ttgaaaattg      180

atattaccaa atctggaaca accaatttaa aataaggaaa gaaagacact gtgttttcta      240

ggttaaaaat gcccagctgg caggggccaa aggagtcatt ctctactcag accctgctga      300

ctactttgct cctggggtga agtcctatcc agacggttgg aatcttcctg gaggtggtgt      360

ccagcgtgga aatatcctaa atctgaatgg tgcaggagac cctctcacac caggttaccc      420

agcaaatgaa tacgcttata ggcatggaat tgcagaggct gttggtcttc caagtattcc      480

tgttcatcca gttggatact atgatgcaca gaagctccta gaaaaaatgg gtggctcagc      540

accaccagat agcagctgga gaggaagtct caaagtgtcc tacaatgttg gacctggctt      600

tactggaaac ttttctacac aaaaagtcaa gatgcacatc cactctacca atgaagtgac      660

gagaatttac aatgtgatag gtactctcag aggagcagtg gaaccagaca gatatgtcat      720

tctgggaggt caccgggact catgggtgtt tggtggtatt gaccctcaga gtggagcagc      780

tgttgttcat gaaactgtga ggagctttgg aacactgaaa aaggaagggt ggagacctag      840

aagaacaatt ttgtttgcaa gctgggatgc agaagaattt ggtcttcttg gttctactga      900

gtgggcagag gataattcaa gactccttca agagcgtggc gtggcttata ttaatgctga      960

ctcatctata gaaggaaact acactctgag agttgattgt acaccactga tgtacagctt     1020

ggtatacaac ctaacaaaag agctgaaaag ccctgatgaa ggctttgaag gcaaatctct     1080

ttatgaaagt tggactaaaa aaagtccttc cccagagttc agtggcatgc ccaggataag     1140

caaattggga tctggaaatg attttgaggt gttcttccaa cgacttggaa ttgcttcagg     1200

cagagcacgg tatactaaaa attgggaaac aaacaaattc agcggctatc cactgtatca     1260

cagtgtctat gaaacatatg agttggtgga aaagttttat gatccaatgt ttaaatatca     1320

cctcactgtg gcccaggttc gaggagggat ggtgtttgag ctagccaatt ccatagtgct     1380

cccttttgat tgtcgagatt atgctgtagt tttaagaaag tatgctgaca aaatctacaa     1440

tatttctatg aaacatccac aggaaatgaa gacatacagt ttatcatttg attcactttt     1500

ttctgcagta aaaaatttta cagaaattgc ttccaagttc agcgagagac tccaggactt     1560

tgacaaaagc aacccaatat tgttaagaat gatgaatgat caactcatgt ttctggaaag     1620

agcatttatt gatccattag ggttaccaga cagacctttt tataggcatg tcatctatgc     1680

tccaagcagc cacaacaagt atgcagggga gtcattccca ggaatttatg atgctctgtt     1740

tgatattgaa agcaaagtgg acccttccaa ggcctgggga gatgtgaaga gacagatttc     1800

tgttgcagcc ttcacagtgc aggcagctgc agagactttg agtgaagtag cctaagagga     1860

ttctttagag actctgtatt gaatttgtgt ggtatgtcac tcaaagaata ataatgggta     1920

tattgataaa ttttaaaatt ggtatatttg aaataaagtt gaatattata tataaaaaaa     1980

aaaaaaaaaa aa                                                         1992


<210>  6
<211>  7391
<212>  DNA
<213>  Homo sapiens

<400>  6
gctgcgcagc gctggctgct ggctggcctc gcggagacgc cgaacggacg cggccggcgc       60

cggcttgtgg gctcgccgcc tgcagccatg accctcgcag cctgtccctc ggcctcggcc      120

cgggacgtct aaaatcccac acagtcgcgc gcagctgctg gagagccggc cgctgccccc      180

tcgtcgccgc atcacactcc cgtcccggga gctgggagca gcgcgggcag ccggcgcccc      240

cgtgcaaact gggggtgtct gccagagcag ccccagccgc tgccgctgct acccccgatg      300

ctggccatgg cctggcgggg cgcagggccg agcgtcccgg gggcgcccgg gggcgtcggt      360

ctcagtctgg ggttgctcct gcagttgctg ctgctcctgg ggccggcgcg gggcttcggg      420

gacgaggaag agcggcgctg cgaccccatc cgcatctcca tgtgccagaa cctcggctac      480

aacgtgacca agatgcccaa cctggttggg cacgagctgc agacggacgc cgagctgcag      540

ctgacaactt tcacaccgct catccagtac ggctgctcca gccagctgca gttcttcctt      600

tgttctgttt atgtgccaat gtgcacagag aagatcaaca tccccattgg cccatgcggc      660

ggcatgtgtc tttcagtcaa gagacgctgt gaacccgtcc tgaaggaatt tggatttgcc      720

tggccagaga gtctgaactg cagcaaattc ccaccacaga acgaccacaa ccacatgtgc      780

atggaagggc caggtgatga agaggtgccc ttacctcaca aaacccccat ccagcctggg      840

gaagagtgtc actctgtggg aaccaattct gatcagtaca tctgggtgaa aaggagcctg      900

aactgtgtgc tcaagtgtgg ctatgatgct ggcttataca gccgctcagc caaggagttc      960

actgatatct ggatggctgt gtgggccagc ctgtgtttca tctccactgc cttcacagta     1020

ctgaccttcc tgatcgattc ttctaggttt tcctaccctg agcgccccat catatttctc     1080

agtatgtgct ataatattta tagcattgct tatattgtca ggctgactgt aggccgggaa     1140

aggatatcct gtgattttga agaggcagca gaacctgttc tcatccaaga aggacttaag     1200

aacacaggat gtgcaataat tttcttgctg atgtactttt ttggaatggc cagctccatt     1260

tggtgggtta ttctgacact cacttggttt ttggcagcag gactcaaatg gggtcatgaa     1320

gccattgaaa tgcacagctc ttatttccac attgcagcct gggccatccc cgcagtgaaa     1380

accattgtca tcttgattat gagactggtg gatgcagatg aactgactgg cttgtgctat     1440

gttggaaacc aaaatctcga tgccctcacc gggttcgtgg tggctcccct ctttacttat     1500

ttggtcattg gaactttgtt cattgctgca ggtttggtgg ccttgttcaa aattcggtca     1560

aatcttcaaa aggatgggac aaagacagac aagttagaaa gactgatggt caagattggg     1620

gtgttctcag tactgtacac agttcctgca acgtgtgtga ttgcctgtta tttttatgaa     1680

atctccaact gggcactttt tcggtattct gcagatgatt ccaacatggc tgttgaaatg     1740

ttgaaaattt ttatgtcttt gttggtgggc atcacttcag gcatgtggat ttggtctgcc     1800

aaaactcttc acacgtggca gaagtgttcc aacagattgg tgaattctgg aaaggtaaag     1860

agagagaaga gaggaaatgg ttgggtgaag cctggaaaag gcagtgagac tgtggtataa     1920

ggctagtcag cctccatgct ttcttcattt tgaagggggg aatgccagca ttttggagga     1980

aattctacta aaagttttat gcagtgaatc tcagtttgaa caaactagca acaattaagt     2040

gacccccgtc aacccactgc ctcccacccc gaccccagca tcaaaaaacc aatgattttg     2100

ctgcagactt tggaatgatc caaaatggaa aagccagtta gaggctttca aagctgtgaa     2160

aaatcaaaac gttgatcact ttagcaggtt gcagcttgga gcgtggaggt cctgcctaga     2220

ttccaggaag tccagggcga tactgttttc ccctgcaggg tgggatttga gctgtgagtt     2280

ggtaactagc agggagaaat attaactttt ttaacccttt accattttaa atactaactg     2340

ggtctttcag atagcaaagc aatctataaa cactggaaac gctgggttca gaaaagtgtt     2400

acaagagttt tatagtttgg ctgatgtaac ataaacatct tctgtggtgc gctgtctgct     2460

gtttagaact ttgtggactg cactcccaag aagtggtgtt agaatctttc agtgcctttg     2520

tcataaaaca gttatttgaa caaacaaaag tactgtactc acacacataa ggtatccagt     2580

ggatttttct tctctgtctt cctctcttaa atttcaacat ctctcttctt ggctgctgct     2640

gttttcttca ttttatgtta atgactcaaa aaaggtattt ttatagaatt tttgtactgc     2700

agcatgctta aagaggggaa aaggaagggt gattcacttt ctgacaatca cttaattcag     2760

aggaaaatga gatttactaa gttgacttac ctgacggacc ccagagacct attgcattga     2820

gcagtgggga cttaatatat tttacttgtg tgattgcatc tatgcagacg ccagtctgga     2880

agagctgaaa tgttaagttt cttggcaact ttgcattcac acagattagc tgtgtaattt     2940

ttgtgtgtca attacaatta aaagcacatt gttggaccat gacatagtat actcaactga     3000

ctttaaaact atggtcaact tcaacttgca ttctcagaat gatagtgcct ttaaaaattt     3060

ttttattttt taaagcataa gaatgttatc agaatctggt ctacttagga caatggagac     3120

tttttcagtt ttataaaggg aactgaggac agctaatcca actacttggt gcgtaattgt     3180

ttcctagtaa ttggcaaagg ctccttgtaa gatttcactg gaggcagtgt ggcctggagt     3240

atttatatgg tgcttaatga atctccagaa tgccagccag aagcctgatt ggttagtagg     3300

gaataaagtg tagaccatat gaaatgaact gcaaactcta atagcccagg tcttaattgc     3360

ctttagcaga ggtatccaaa gcttttaaaa tttatgcata cgttcttcac aagggggtac     3420

ccccagcagc ctctcgaaaa ttgcacttct cttaaaactg taactggcct ttctcttacc     3480

ttgccttagg ccttctaatc atgagatctt ggggacaaat tgactatgtc acaggttgct     3540

ctccttgtaa ctcatacctg tctgcttcag caactgcttt gcaatgacat ttatttatta     3600

attcatgcct taaaaaaata ggaagggaag cttttttttt tctttttttt tttttcaatc     3660

acactttgtg gaaaaacatt tccagggact caaaattcca aaaaggtggt caaattctgg     3720

aagtaagcat ttcctctttt ttaaaaattt ggtttgagcc ttatgcccat agtttgacat     3780

ttccctttct tctttccttt ttgtttttgt gtggttcttg agctctctga catcaagatg     3840

catgtaaagt cgattgtatg ttttggaagg caaagtcttg gcttttgaga ctgaagttaa     3900

gtgggcacag gtggcccctg ctgctgtgcc cagtctgagt accttggcta gactctaggt     3960

caggctccag gagcatgaga attgatcccc agaagaacca ttttaactcc atctgatact     4020

ccattgccta tgaaatgtaa aatgtgaact ccctgtgctg cttgtagaca gttcccataa     4080

ctgtccacgg ccctggagca cgcacccagg ggcagagcct gcccttactc acgctctgct     4140

ctggtgtctt gggagttgtg cagggactct ggcccaggca ggggaaggaa gaccaggcgg     4200

taggggactg gtcttgctgt tagagtatag aggtttgtaa tgcagttttc ttcataatgt     4260

gtcagtgatt gtgtgaccaa ggcagcatct agcagaaagc caggcatgga gtaggtgatc     4320

gatacttgtc aatgactaaa taataacaat aaaagagcac ttgggtgaat ctgggcacct     4380

gatttctgag ttttgagttc tggagctagt gttttgacaa tgctttgggt tttgacatgc     4440

cttttccaca aatctcttgc cttttcaggg caaagtgtat ttgatcagaa gtggccattt     4500

ggattagtag ccttagcaat gctacagggt tataggcctc tcctttcaca ttccagacaa     4560

tggagagtgt ttatggtttc aggaaaagaa ctttgtggct gaggggtcag ttaccagtga     4620

ccttcaatca actccatcac ttcttaaatc ggtatttgtt aaaaaaatca gttattttat     4680

ttattgagtg ccgactgtag taaagccctg aaatagataa tctctgttct tctaactgat     4740

ctaggatggg gacgcaccca ggtctgctga actttactgt tcctctggga aaggagcagg     4800

gacctctgga attcccatct gtttcactgt ctccattcca taaatctctt cctgtgtgag     4860

ccaccacacc cagcctgggt ctctctactt ttaacacatc tctcatccct ttcccaggat     4920

tccttccaag tcagttacag gtggttttaa cagaaagcat cagctctgct tcgtgacagt     4980

ctctggagaa atcccttagg aagactatga gagtaggcca caaggacatg ggcccacaca     5040

tctgctttgg ctttgccggc aattcagggc ttggggtatt ccatgtgact tgtataggta     5100

tatttgagga cagcatcttg ctagagaaaa ggtgagggtt gtttttcttt ctctgaaacc     5160

tacagtaaat gggtatgatt gtagcttcct cagaaatccc ttggcctcca gagattaaac     5220

atggtgcaat ggcacctctg tccaacctcc tttctggtag attcctttct cctgcttcat     5280

ataggccaaa cctcagggca agggaacatg ggggtagagt ggtgctggcc agaaccatct     5340

gcttgagcta cttggttgat tcatatcctc tttcctttat ggagacccat ttcctgatct     5400

ctgagactgt tgctgaactg gcaacttact tgggcctgaa actggagaag gggtgacatt     5460

tttttaattt cagagatgct ttctgatttt cctctcccag gtcactgtct cacctgcact     5520

ctccaaactc aggttccggg aagcttgtgt gtctagatac tgaattgaga ttctgttcag     5580

caccttttag ctctatactc tctggctccc ctcatcctca tggtcactga attaaatgct     5640

tattgtattg agaaccaaga tgggacctga ggacacaaag atgagctcaa cagtctcagc     5700

cctagaggaa tagactcagg gatttcacca ggtcggtgca gtatttgatt tctggtgagg     5760

tgaccacagc tgcagttagg gaagggagcc attgagcaca gactttggaa ggaacctttt     5820

ttttgttgtt tgtttgtttg tttgtttgtt tgtttgtttg agacagggtc ttgctctgtc     5880

acccaggctg gggcgcaatg gcacgatctt ggctcactgc aacctctgcc tcctgggttc     5940

aagtgattct cctgccacag cctcctgagg agctgggact acaggtgcgt gctaccacgc     6000

ccagctactt ctgtattttt agtagagacg gggtttcact gtgttggcca ggctggtctc     6060

gaactcctga cctcatgatc tgcccgcctc agcctcccaa agtgctggga ttacaagtgt     6120

gagccaccac acctggcctg gaaggaacct cttaaaatca gtttacgtct tgtattttgt     6180

tctgtgatgg aggacactgg agagagttgc tattccagtc aatcatgtcg agtcactgga     6240

ctctgaaaat cctattggtt cctttatttt atttgagttt agagttccct tctgggtttg     6300

tattatgtct ggcaaatgac ctgggttatc acttttcctc cagggttaga tcatagatct     6360

tggaaactcc ttagagagca ttttgctcct accaaggatc agatactgga gccccacata     6420

atagatttca tttcactcta gcctacatag agctttctgt tgctgtctct tgccatgcac     6480

ttgtgcggtg attacacact tgacagtacc aggagacaaa tgacttacag atcccccgac     6540

atgcctcttc cccttggcaa gctcagttgc cctgatagta gcatgtttct gtttctgatg     6600

tacctttttt ctcttcttct ttgcatcagc caattcccag aatttcccca ggcaatttgt     6660

agaggacctt tttggggtcc tatatgagcc atgtcctcaa agcttttaaa cctccttgct     6720

ctcctacaat attcagtaca tgaccactgt catcctagaa ggcttctgaa aagaggggca     6780

agagccactc tgcgccacaa aggttgggtc catcttctct ccgaggttgt gaaagttttc     6840

aaattgtact aataggctgg ggccctgact tggctgtggg ctttgggagg ggtaagctgc     6900

tttctagatc tctcccagtg aggcatggag gtgtttctga attttgtcta cctcacaggg     6960

atgttgtgag gcttgaaaag gtcaaaaaat gatggcccct tgagctcttt gtaagaaagg     7020

tagatgaaat atcggatgta atctgaaaaa aagataaaat gtgacttccc ctgctctgtg     7080

cagcagtcgg gctggatgct ctgtggcctt tcttgggtcc tcatgccacc ccacagctcc     7140

aggaaccttg aagccaatct gggggacttt cagatgtttg acaaagaggt accaggcaaa     7200

cttcctgcta cacatgccct gaatgaattg ctaaatttca aaggaaatgg accctgcttt     7260

taaggatgta caaaagtatg tctgcatcga tgtctgtact gtaaatttct aatttatcac     7320

tgtacaaaga aaaccccttg ctatttaatt ttgtattaaa ggaaaataaa gttttgtttg     7380

ttaaaaaaaa a                                                          7391


<210>  7
<211>  2304
<212>  DNA
<213>  Homo sapiens

<400>  7
tggctggcaa tggccttgct gacctcgagc cgggcccacg tggggacctt tggagcacag       60

cctacgatcc tggtgcaagg ccggtggatg cagaggccag tccatatacc acccaggcct      120

gcgaggagcg tggtccccac ccatccagcc catatgtgca agtgcccttg acagagaggc      180

tggtcatatc catggtgacc atttatgggc cacaacaggt ccccatctgc gcagtgaacc      240

ctgtgctgag caccttgcag acgtgatctt gcttcgtcct gcagcactgt gcggggcagg      300

aaaatccaag aggaagaagg atctacggat atcctgcatg tccaagccac ccgcacccaa      360

ccccacaccc ccccggaacc tggactcccg gaccttcatc accattggag acagaaactt      420

tgaggtggag gctgatgact tggtgaccat ctcagaactg ggccgtggag cctatggggt      480

ggtagagaag gtgcggcacg cccagagcgg caccatcatg gccgtgaagc ggatccgggc      540

caccgtgaac tcacaggagc agaagcggct gctcatggac ctggacatca acatgcgcac      600

ggtcgactgt ttctacactg tcaccttcta cggggcacta ttcagagagg gagacgtgtg      660

gatctgcatg gagctcatgg acacatcctt ggacaagttc taccggaagg tgctggataa      720

aaacatgaca attccagagg acatccttgg ggagattgct gtgtctatcg tgcgggccct      780

ggagcatctg cacagcaagc tgtcggtgat ccacagagat gtgaagccct ccaatgtcct      840

tatcaacaag gagggccatg tgaagatgtg tgactttggc atcagtggct acttggtgga      900

ctctgtggcc aagacgatgg atgccggctg caagccctac atggcccctg agaggatcaa      960

cccagagctg aaccagaagg gctacaatgt caagtccgac gtctggagcc tgggcatcac     1020

catgattgag atggccatcc tgcggttccc ttacgagtcc tgggggaccc cgttccagca     1080

gctgaagcag gtggtggagg agccgtcccc ccagctccca gccgaccgtt tctcccccga     1140

gtttgtggac ttcactgctc agtgcctgag gaagaacccc gcagagcgta tgagctacct     1200

ggagctgatg gagcacccct tcttcacctt gcacaaaacc aagaagacgg acattgctgc     1260

cttcgtgaag gagatcctgg gagaagactc ataggggctg ggcctcggac cccactccgg     1320

ccctccagag ccccacagcc ccatctgcgg gggcagtgct cacccacacc ataagctact     1380

gccatcctgg cccagggcat ctgggaggaa ccgagggggc tgctcccacc tggctctgtg     1440

gcgagccatt tgtcccaagt gccaaagaag cagaccattg gggctcccag ccaggccctt     1500

gtcggcccca ccagtgcctc tccctgctgc tcctaggacc cgtctccagc tgctgagatc     1560

ctggactgag ggggcctgga tgccccctgt ggatgctgct gcccctgcac agcaggctgc     1620

cagtgcctgg gtggatgggc caccgccttg cccagcctgg atgccatcca agttgtatat     1680

ttttttaatc tctcgactga atggactttg cacactttgg cccagggtgg ccacacctct     1740

atcccggctt tggtgcgggg tacacaagag gggatgagtt gtgtgaatac cccaagactc     1800

ccatgaggga gatgccatga gccgcccaag gccttcccct ggcactggca aacagggcct     1860

ctgcggagca cactggctca cccagtcctg cccgccaccg ttatcggtgt cattcacctt     1920

tcgtgttttt tttaatttat cctctgttga ttttttcttt tgctttatgg gtttggcttg     1980

tttttcttgc atggtttgga gctgatcgct tctcccccac cccctagggt accagcaggc     2040

agagccttgc cctctgctca ggctggggtc cagtgggagg ggcccaagat ctctgctcag     2100

agaagtgcag ggggagcctt ccagctcact ctccctgagg actggcttga caggggctat     2160

gggtttgctt tggtgttgtt tttaaaaaaa gaaaatatat ttttttgaaa aaacgactgc     2220

ccatcccggg tcctttccct gatgggttgg ggcagttacc tggttgctgt tttaattaaa     2280

aaaaaaaaaa aaaaaaggac taaa                                            2304


<210>  8
<211>  2319
<212>  DNA
<213>  Homo sapiens

<400>  8
gcaggggcgg ggcctgagtc agcgcagttc ggccggggtc tccccggcgc tgcccagtct       60

gtctccggcg ccgcccgtcg cggactcgtc cttgctgcag tcgccgccgc agtcctcgcc      120

gcagtcgccg ccgccgccgc cgccgccgcc gctgctcctc cgcctggcct gggccgtctg      180

cccgcagcca tgagcgtgct cggccccggt ggagcccgca gtcctctaga ttagtctcca      240

ccgccgtcca ggacccactt gcagcatgga gtcgcccgcc tcgagccagc ccgccagcat      300

gccccagtcc aaaggaaaat ccaagaggaa gaaggatcta cggatatcct gcatgtccaa      360

gccacccgca cccaacccca cacccccccg gaacctggac tcccggacct tcatcaccat      420

tggagacaga aactttgagg tggaggctga tgacttggtg accatctcag aactgggccg      480

tggagcctat ggggtggtag agaaggtgcg gcacgcccag agcggcacca tcatggccgt      540

gaagcggatc cgggccaccg tgaactcaca ggagcagaag cggctgctca tggacctgga      600

catcaacatg cgcacggtcg actgtttcta cactgtcacc ttctacgggg cactattcag      660

agagggagac gtgtggatct gcatggagct catggacaca tccttggaca agttctaccg      720

gaaggtgctg gataaaaaca tgacaattcc agaggacatc cttggggaga ttgctgtgtc      780

tatcgtgcgg gccctggagc atctgcacag caagctgtcg gtgatccaca gagatgtgaa      840

gccctccaat gtccttatca acaaggaggg ccatgtgaag atgtgtgact ttggcatcag      900

tggctacttg gtggactctg tggccaagac gatggatgcc ggctgcaagc cctacatggc      960

ccctgagagg atcaacccag agctgaacca gaagggctac aatgtcaagt ccgacgtctg     1020

gagcctgggc atcaccatga ttgagatggc catcctgcgg ttcccttacg agtcctgggg     1080

gaccccgttc cagcagctga agcaggtggt ggaggagccg tccccccagc tcccagccga     1140

ccgtttctcc cccgagtttg tggacttcac tgctcagtgc ctgaggaaga accccgcaga     1200

gcgtatgagc tacctggagc tgatggagca ccccttcttc accttgcaca aaaccaagaa     1260

gacggacatt gctgccttcg tgaaggagat cctgggagaa gactcatagg ggctgggcct     1320

cggaccccac tccggccctc cagagcccca cagccccatc tgcgggggca gtgctcaccc     1380

acaccataag ctactgccat cctggcccag ggcatctggg aggaaccgag ggggctgctc     1440

ccacctggct ctgtggcgag ccatttgtcc caagtgccaa agaagcagac cattggggct     1500

cccagccagg cccttgtcgg ccccaccagt gcctctccct gctgctccta ggacccgtct     1560

ccagctgctg agatcctgga ctgagggggc ctggatgccc cctgtggatg ctgctgcccc     1620

tgcacagcag gctgccagtg cctgggtgga tgggccaccg ccttgcccag cctggatgcc     1680

atccaagttg tatatttttt taatctctcg actgaatgga ctttgcacac tttggcccag     1740

ggtggccaca cctctatccc ggctttggtg cggggtacac aagaggggat gagttgtgtg     1800

aataccccaa gactcccatg agggagatgc catgagccgc ccaaggcctt cccctggcac     1860

tggcaaacag ggcctctgcg gagcacactg gctcacccag tcctgcccgc caccgttatc     1920

ggtgtcattc acctttcgtg ttttttttaa tttatcctct gttgattttt tcttttgctt     1980

tatgggtttg gcttgttttt cttgcatggt ttggagctga tcgcttctcc cccaccccct     2040

agggtaccag caggcagagc cttgccctct gctcaggctg gggtccagtg ggaggggccc     2100

aagatctctg ctcagagaag tgcaggggga gccttccagc tcactctccc tgaggactgg     2160

cttgacaggg gctatgggtt tgctttggtg ttgtttttaa aaaaagaaaa tatatttttt     2220

tgaaaaaacg actgcccatc ccgggtcctt tccctgatgg gttggggcag ttacctggtt     2280

gctgttttaa ttaaaaaaaa aaaaaaaaaa aggactaaa                            2319


<210>  9
<211>  4109
<212>  DNA
<213>  Homo sapiens

<400>  9
gcaaaatggt ccctcacctc ttgctgctct gtctcctccc cttggtgcga gccaccgagc       60

cccacgaggg ccgggccgac gagcagagcg cggaggcggc cctggccgtg cccaatgcct      120

cgcacttctt ctcttggaac aactacacct tctccgactg gcagaacttt gtgggcagga      180

ggcgctacgg cgctgagtcc cagaacccca cggtgaaagc cctgctcatt gtggcttact      240

ccttcatcat tgtcttctca ctctttggca acgtcctggt ctgtcatgtc atcttcaaga      300

accagcgaat gcactcggcc accagcctct tcatcgtcaa cctggcagtt gccgacataa      360

tgatcacgct gctcaacacc cccttcactt tggttcgctt tgtgaacagc acatggatat      420

ttgggaaggg catgtgccat gtcagccgct ttgcccagta ctgctcactg cacgtctcag      480

cactgacact gacagccatt gcggtggatc gccaccaggt catcatgcac cccttgaaac      540

cccggatctc aatcacaaag ggtgtcatct acatcgctgt catctggacc atggctacgt      600

tcttttcact cccacatgct atctgccaga aattatttac cttcaaatac agtgaggaca      660

ttgtgcgctc cctctgcctg ccagacttcc ctgagccagc tgacctcttc tggaagtacc      720

tggacttggc caccttcatc ctgctctaca tcctgcccct cctcatcatc tctgtggcct      780

acgctcgtgt ggccaagaaa ctgtggctgt gtaatatgat tggcgatgtg accacagagc      840

agtactttgc cctgcggcgc aaaaagaaga agaccatcaa gatgttgatg ctggtggtag      900

tcctctttgc cctctgctgg ttccccctca actgctacgt cctcctcctg tccagcaagg      960

tcatccgcac caacaatgcc ctctactttg ccttccactg gtttgccatg agcagcacct     1020

gctataaccc cttcatatac tgctggctga acgagaactt caggattgag ctaaaggcat     1080

tactgagcat gtgtcaaaga cctcccaagc ctcaggagga caggcaaccc tccccagttc     1140

cttccttcag ggtggcctgg acagagaaga atgatggcca gagggctccc cttgccaata     1200

acctcctgcc cacctcccaa ctccagtctg ggaagacaga cctgtcatct gtggaaccca     1260

ttgtgacgat gagttagaag aggttgggaa gagggagtgg gaggggtctg tctccacctg     1320

aggcagggaa agagagccta ttctcacaca tgatcttcag agtgctggaa acacactcct     1380

gcagaagctg taggactctt gaattcctag gaaactgtcc agcctcctag ccccatgtga     1440

tgtgaaaact aaaaggcacc accaactaga catgtgttca taaattccca tctaagaaac     1500

actgggaggc acagcagcct gtatctctga ggaagaggag cgaggacaac gttggcccag     1560

atgggggctg aatcattcaa ctgcctccat ctgtggggca gctgctgcct tacagccctt     1620

cctactgctg agcatcccga agggagacct aaatcatact ttgggtgtgg tgacccagat     1680

gcacagagct ctgcttgaaa caggtacacg ggccagggaa atgccagcaa gccagagcgg     1740

gcgtggagat ttttatgcct cactttctgg agtcactggg ccatgatgaa tcataagtct     1800

tcagtggcct agcaatatcc agataagaaa ggaccaactt gggttcctta aaacaaaggg     1860

aaattattat tgccacttag aaaaattcag aaaagcacac actcacatac acacacacaa     1920

aatcactctc ttatcccatc catttgtgat aacatctgtg aacatgctgt ggctctattt     1980

gcaacatttt ccttcgtgtg tgtgattgtg tgcatgtgtg catgaccttt ttttttcttt     2040

tttttttttt tttttgagat ggaatctcgc tctgtcaccc aggttggagt tcagtggcac     2100

aatctcggct cactgcaagc tctgcctccc aggttcatgc cgttctcctg cctcagcctc     2160

cctagtagct gggactacag gtgcccgcca ccatgcccgg ctaatctttt gcatttttag     2220

tagagacggg gtttcaccgt gttagccagg atggtctcga tctcctgacc tcgtgatcca     2280

cctgcctagg cctcccaaag tgttgggatt acaggcgtga gccaccccgc ccggcccttt     2340

tttttcattt atactttttc atttagattg taatgattaa cagaaacagg ggtacctttc     2400

ccaggggtgt ccaccagaag agttgaagaa gaggtgagaa gatcccaagg tgaagcctgt     2460

caccacgcag acagaactgc cccctattgt agacagtggt gggaagggcc tggctcacat     2520

gcccctcctt agaggcagcc tcaagatgaa ccagggaatc aaactcaacc aggaggcatg     2580

attccttctc tcctgcaatt gcacaaaaac aagtggtggt gaaacattgt tctgttttca     2640

caagagatga gggagcaggc tttccaatat gctggaagta attgtgctta gacacctcat     2700

cctcccaagc tgtctagaaa ggccatttcg ctgtgttgtc taaataatga gggttttttc     2760

acaccatttc tcaaaaggag attcgctgtc aacatcattt tggtggttca ggtgtcactt     2820

tcacttacag aaacttatgc atccttaaga gatctcaatt cttaagggtc taacttgcca     2880

gagaaatctc attccaggga ctgattgttt ttatcacctt ctgtctggtc ctgagtgact     2940

cactgtgtca cccagaaaag agacctgtca ggcagaatcg agcttaattc acctgctcta     3000

aacaattgtt actgacacac tgcttttagg ttttcttcta gcaccagata aactctgaaa     3060

tcaaagcatg gatatgagct cagtaggaaa ctaaggtttg agggagaaag agtttgtcac     3120

ttagacctct tggctgttaa ctgaaactga acttgctcac atcatctgct tccctgtaat     3180

gaactatgag ggttctttat cctagtttct atttatgaag atggttgaaa attttcaaga     3240

cacaagattt tgaaaactca ctgaattatg ggcaaaacca tgactttcat tgggcagaca     3300

gagtcttcta agcccacagg gatccccaga tggatttttc aggacaaatg gctcatgtgc     3360

ctgtacttat tgtctctgtg gtgtgtcaag aagtagctaa tggtttcatc tgaaagctgc     3420

catagaaatt ctgtgaacca gaatgagaca aggcagcagg catacagaag gtttgtcctg     3480

ctctgggaag catggaggat gttgtacttc actcctctct gagggtgtct aggaatacag     3540

aagctccttg acttacatct caataaaccc atcgtaagtc caaaatattg gaagttgaaa     3600

atgcattgaa tacacccaac ctactgaaca tcgtagctta gccaagccta ccttaaatgc     3660

tctgagaaca cttatattag cctacagctg ggaaaaatca tttaacacaa agcctatctt     3720

ctaatgaagt atggaatatc tcatgtaatt tattgaatac tgtactgaag gtgaaaacca     3780

gaatggttgt atggatatgc gaagtatggt ttctactgaa tgtgtattgc tttcccatca     3840

tcataaaatt tttaaaaatc ctaagttgaa tcattgttag tccgggacct tcagtactgc     3900

caagtcccag agaaaaccct tttactctgg ggagaaccca ctgatggctc attagatctg     3960

tcccttcccc gaggtccgtg tgtgactttg agcaaaaagt gacttctttt tgtgaatgta     4020

aaatttgtga aacttgagtt tttccaatgt gctgtaaagt gttttattgt aaattgctca     4080

tctcaataaa atttacttca ggtttgtgg                                       4109


<210>  10
<211>  3288
<212>  DNA
<213>  Homo sapiens

<400>  10
gctccctccc ctcctagctg gcttcggcgg ggacggcggc ggcggcggcg ggcggggagg       60

gcgtgcgccg gccgagaggt gtcggcggcg aggcaaagga agtttcaagt ggaaggtcgt      120

ccgtcggccg gcgcgtcctc ctgctctcct ccgcagcatc atggcggagc cgagcggctc      180

gcccgtgcac gtccagcttc cccagcaggc ggccccggtg acagcggcgg cggcggcggc      240

cccggcggcc gcgacagcag cgccggcccc ggcagctccc gcggccccgg ccccggcccc      300

ggccccggcg gcacaggctg tcggctggcc catctgcagg gacgcgtacg agctgcagga      360

ggttatcggc agtggagcta ctgctgtggt tcaggcagcc ctatgcaaac ccaggcaaga      420

acgtgtagca ataaaacgga tcaacttgga aaaatgccag accagtatgg atgaactatt      480

aaaagaaatt caagccatga gtcagtgcag ccatcccaac gtagtgacct attacacctc      540

ttttgtggtc aaagatgaac tttggctggt catgaaatta ctaagtggag gttcaatgtt      600

ggatatcata aaatacattg tcaaccgagg agaacacaag aatggagttc tggaagaggc      660

aataatagca acaattctta aagaggtttt ggaaggctta gactatctac acagaaacgg      720

tcagattcac agggatttga aagctggtaa tattcttctg ggtgaggatg gttcagtaca      780

aatagcagat tttggggtaa gtgcgttcct agcaacaggg ggtgatgtta cccgaaataa      840

agtaagaaaa acattcgttg gcaccccatg ttggatggct cctgaagtca tggaacaggt      900

gagaggctat gacttcaagg ctgacatgtg gagttttgga ataactgcca ttgaattagc      960

aacaggagca gcgccttatc acaaatatcc tcccatgaaa gtgttaatgt tgactttgca     1020

aaatgatcca cccactttgg aaacaggggt agaggataaa gaaatgatga aaaagtacgg     1080

caagtccttt agaaaattac tttcactgtg tcttcagaaa gatccttcca aaaggcccac     1140

agcagcagaa cttttaaaat gcaaattctt ccagaaagcc aagaacagag agtacctgat     1200

tgagaagctg cttacaagaa caccagacat agcccaaaga gccaaaaagg taagaagagt     1260

tcctgggtca agtggtcacc ttcataaaac cgaagacggg gactgggagt ggagtgacga     1320

cgagatggat gagaagagcg aagaagggaa agcagctttt tctcaggaaa agtcacgaag     1380

agtaaaagaa gaaaatccag agattgcagt gagtgccagc accatccccg aacaaataca     1440

gtccctctct gtgcacgact ctcagggccc acccaatgct aatgaagact acagagaagc     1500

ttcttcttgt gccgtgaacc tcgttttgag attaagaaac tccagaaagg aacttaatga     1560

catacgattt gagtttactc caggaagaga tacagcagat ggtgtatctc aggagctctt     1620

ctctgctggc ttggtggatg gtcacgatgt agttatagtg gctgctaatt tacagaagat     1680

tgtagatgat cccaaagctt taaaaacatt gacatttaag ttggcttctg gctgtgatgg     1740

gtcggagatt cctgatgaag tgaagctgat tgggtttgct cagttgagtg tcagctgatg     1800

tatgtccctt gatgtcaccc tgatctgtca tgccccaccg ccacccctac tcccttcaac     1860

cctccctctt tctgcccatt tcctcccacc ccctcactcc catttcctag caaaatcaga     1920

agattgtgaa gaggccggct tcaacaaaat gggataaaaa aataattttt taaaacttac     1980

aacactccga gttctgcttt attctctagc aatccacagt acaagaacaa gcaaatgcca     2040

cagctgcacg actgttgctc atttttccaa aagctattta atattcttag caatcaattt     2100

ggatatccct taagtgaaaa gaatctgaaa tacactcagg tggtcttatt tattggcaac     2160

aaaaggaatt ttctatccag aagcctattt ctcctttcat tgttgttatt tctgttataa     2220

tactttaatt gtacatctga caatactgcc tcttttatgt tgtatttaga aattaatata     2280

cttataaaat taagatttat tagccaaact tgaattctag ttttaaaact gactgtgaat     2340

tttatttttc atatatttat gcattacaca ccttagctat aagaaaaaaa gggttttgat     2400

tatatgcttc ttgcagttaa tctcgttatt taaacaaaaa gttttgggtc tgtctttgga     2460

gtatttgtaa cttctaaatt ttgaaatgac tgaattagga atttggatgc ttattctttt     2520

agtctgtttg cctaaaaacc aatttacaat ctgactgtct cttgggagag ggaggtgcct     2580

tgcaaacttt cacattaaga atgtgcctga ggctgcttta ctctggaata gtctcagatc     2640

taaaatttcc tctatataag gtggcatatg ttaagttttg cttcattgga ccgtttagaa     2700

tgctatgtaa aatgttgcca ttctgttaga ttgctaacta tatacccatc tctgatttgg     2760

ctctccttaa gtgataggat ttgttattct aaaggtgata aacttgaaaa tatcagaatc     2820

tgagttttac ttgaaatttt gcagaatacc caggtggagt gaaaattgga agggttttgt     2880

gcaatgacta aaaggtaaaa cgctgttaag gttcaagaat caatactttc aacccaagta     2940

gccctctgct tgactgtata ttatggaact agtaaacctt aggattttga aaattggagt     3000

ctaatctttc aaggaggtgg gctcccagga tggtaccatt gctctttcct agctaaccct     3060

agatatggca gctctttaat gtacttcaaa aagcaaatat atattactaa ggaaaaaaag     3120

ttatttataa ttgccttgtc ataattgtta aggtgttcta gagccatttg catacaattt     3180

aatgtaattt cattccattc tattgtttac acaacgatta ctcgaagatg actgcaaagg     3240

taaaaggaaa ataaaagtgt attgcacaat gagaaaaaaa aaaaaaaa                  3288


<210>  11
<211>  5807
<212>  DNA
<213>  Homo sapiens

<400>  11
gcgcgcgcga gggcgttggg cgccgccgcg aggcggggaa gcgcggggcc gcggcggtgc       60

gggttctagg gcggcggccg tcgccgtcgc agcagcgccc cgagcgggga gggccgagga      120

ggcccgacga gctggggatg gagagtaccg ggcccctcac tgcctcagag cgcgtgtgcg      180

gctctgggcg cgcacagtga cggtgacggc acccctggcc cggcagcgcc gaggccgctt      240

cgccagacag ccagcggccg gcggcaggcc gggccatgag cggcaggggc cgggccgggc      300

ctcgctgacc ctggctccgc gcggcagctt ccccagtttc cgctccggtc tctcggcatg      360

agagtccgcc cgggcccggg gctgcggctg ccccagaccc gccgcacgct ggcgcgctcc      420

gggcccgcgg agccgcggtg ctgatacctg cgccgcactg cgccgcccgc ccgtccgctg      480

tgtgccccgg gggcgcggcc atggaggtgg tgggtgactt cgagtacagc aagagggatc      540

tcgtgggaca cggggccttc gccgtggtct tccgggggcg gcaccgccag aaaactgatt      600

gggaggtagc tattaaaagt attaataaaa agaacttgtc aaaatcacaa atactgcttg      660

gaaaggaaat taaaatctta aaggaacttc agcatgaaaa tattgtagca ctctatgatg      720

ttcaggaatt acccaactct gtctttttgg tgatggagta ttgcaatggt ggagacctcg      780

cagattattt gcaagcgaaa gggactctca gtgaagacac gatcagagtg tttctgcatc      840

agattgctgc tgccatgcga atcctgcaca gcaaaggaat catccacaga gatctcaaac      900

cacagaacat cttgctgtcc tatgccaatc gcagaaaatc aagtgtcagt ggtattcgca      960

tcaaaatagc ggattttggt tttgctcgtt acctacatag taacatgatg gctgcaacac     1020

tgtgtggatc cccgatgtac atggctcctg aggttattat gtctcaacat tatgatgcta     1080

aggctgactt gtggagcata ggaacagtga tataccaatg cctagttgga aaaccacctt     1140

ttcaggccaa tagtcctcaa gacttaagga tgttttatga aaaaaacagg agcttaatgc     1200

ctagtattcc cagagaaaca tcaccttatt tggctaatct ccttttgggt ttgcttcaga     1260

gaaaccaaaa agatagaatg gactttgaag cgttttttag ccatcctttt cttgagcaag     1320

gtccagtaaa aaaatcttgc ccagttccag tgcccatgta ttctggttct gtctctggaa     1380

gctcctgtgg cagctctcca tcttgtcgtt ttgcttctcc accatccctt ccagatatgc     1440

agcatattca ggaagaaaac ttatcttccc caccattggg tcctcccaac tatctacaag     1500

tttccaaaga ttctgccagt actagtagca agaactcttc ttgtgacacg gatgactttg     1560

ttttggtgcc acacaacatc tcgtcagacc actcatgtga tatgccaatg gggactgctg     1620

gcagacgtgc ttcaaatgaa ttcttggtgt gtggagggca gtgtcagcct actgtgtcac     1680

ctcacagcga aacagcacca attccagttc ctactcaaat aaggaattat cagcgcatag     1740

agcagaatct tacatctact gccagctcag gcacaaatgt acatggttct ccaagatctg     1800

cagtggtacg aaggtccaac accagcccca tgggcttcct ccggccggga tcatgctccc     1860

cagtaccagc agacacagca cagacagttg gacgaaggct ctccactggg tcttctaggc     1920

cttactcacc ttcccctttg gttggtacca ttcctgagca attcagtcag tgctgctgtg     1980

ggcatcctca gggccatgac tccaggagta gaaactcctc aggttctcca gtgccacaag     2040

ctcagtcccc acagtctctc ttatcgggtg ctagactgca gagcgccccc accctcactg     2100

acatctatca gaacaagcag aagctcagaa aacagcactc tgaccccgtg tgcccatccc     2160

atactggggc tgggtacagc tactcgcctc agcccagtcg gcctggcagc cttggaactt     2220

ctcccaccaa gcacttgggg tcctctccac ggagttctga ctggttcttt aaaactcctt     2280

tgccaacaat cattggctct cctactaaga ccacagctcc tttcaaaatc cctaaaactc     2340

aagcatcttc caacctgtta gccttggtta ctcgtcatgg gcctgctgaa gaacagtcga     2400

aagatgggaa tgagccacgg gaatgtgccc attgcctctt agtgcaagga agtgagaggc     2460

agcgggccga gcagcagagc aaggcagtgt ttggcagatc tgtcagtacc gggaagttat     2520

cagatcaaca aggaaagact cctatatgtc gacatcaggg cagcacagac agtttaaata     2580

cagaacgacc aatggatata gctccggcag gagcctgtgg tggtgttctg gcacctcctg     2640

caggtacagc agcaagttcc aaggctgtcc tcttcactgt agggtctcct ccacacagtg     2700

cggcagcccc cacttgtacc cacatgttcc ttcgaacaag aacaacctca gtggggccca     2760

gcaactccgg gggctctctt tgtgccatga gtggccgcgt gtgcgtgggg tccccgcctg     2820

gcccaggctt cggctcttcc cctccaggag cagaggcagc tcccagcctg agatacgtgc     2880

cttacggtgc ttcacccccc agcctagagg ggctcatcac ctttgaagcc cctgaactgc     2940

cggaggagac gctgatggag cgggaacaca cagacacctt acgccatctg aatgtgatgc     3000

tgatgttcac tgagtgtgtg ctggacctga cagccatgag gggaggaaac cctgagctgt     3060

gcacatctgc tgtgtccttg taccagatcc aggagagtgt ggtggtggac cagatcagtc     3120

agctgagcaa agactggggg tgggtggagc agctggtgtt gtacatgaaa gcagcacagc     3180

tgcttgcggc ttctctgcat cttgccaaag cccagatcaa gtccgggaaa ctgagcccat     3240

ccacagctgt gaaacaagtt gtcaagaatc tgaacgaacg atataaattc tgcatcacca     3300

tgtgcaagaa acttacagaa aagctgaatc gattcttctc tgacaaacag aggtttattg     3360

atgaaatcaa cagtgtgact gcagagaaac tcatctataa ttgtgctgta gaaatggttc     3420

agtctgcagc cctggatgag atgtttcagc agaccgaaga tattgtttat cgctatcata     3480

aggcagccct tcttttggaa ggcctaagta ggattctaca ggaccctgca gatattgaaa     3540

atgtgcataa atataaatgt agtattgaga gaagactgtc ggcgctctgc catagcaccg     3600

caaccgtgtg agcagcaggc tcatcccgtg gaccggtggt gggaacgtga ggtgatgcct     3660

ttgggattac agcttgagtt ctgtcacccc atccccagga aactgtagct tcttaactgg     3720

tgactaccaa agaacaagca gtgatttgaa aaaggaaaaa caatccaaaa actacatatt     3780

tgtaggaaat ctgccttatt ggagaaaatc accctttccc tttttctttg tagaagcagg     3840

agcaagagtg tttggctccc agtttggact tggtgaataa atgtacctta gaactaggat     3900

aatcggtaca gttattctta aagataatta aaaatgaaac aaagtgagtg ctcgtcactg     3960

ggttcatcag agcagtgtgt gaaattccat gtgtttgctg aggtgtaaag gtaaatgtat     4020

tcacccctca tccaggcagt ttgatatttg gagtaagttt gtttaaatct gagcatgcat     4080

ctttaaacag ctcaggaaga aatagcttaa gaagaagtga aacatggatc ttggaagaaa     4140

ttttgaaatc ttcaatttga tcctaatatg gatacatgtt aatcttccaa aatctttcat     4200

attgcactaa tttattaaaa caactgtgta ttggattttg taatttaact aaggcacaat     4260

ggacttgttt aaaatatttt acttgattgt atacatagac cctttccaga attcacatgt     4320

aatctccagt gaacttttaa gtggttaaaa cttgtattca tgtgaacctt tgcacatttt     4380

ttttttttac ttctttatct acacctacag attttctcag taatgttttt gttagctttt     4440

ggttccattt tttattgtgc atgcagaatg tacattgatg cctgtgacct taggtttatt     4500

aaaggctagg tttatttggg cagtattaga aacaaaatca tggatcaaga gatactcttg     4560

ataatttgaa tagggccaaa acaaagttgg tgacctaaag gcttgttagt gatgtggagt     4620

tcctacatgc agtgagtgga aaatgaagtt cgttttctct taggaaaatg ggcagctgtc     4680

ttctgcctaa tgtgtatttt tcatgttaat tctgacagtt caccaaatag ctagtcatgg     4740

agaatgcagg cagttaactt aatatccctc caggaatggt tcctacgttg tgtattattt     4800

ggtttctttt acttacctgc ttgaatactt gaataaacca ttcaccaatt ttaatccttt     4860

tattttaatc cttttacata aaataatctg aactctttga caaattgcac agagctcttt     4920

ggcattaatc taattttaat gtactgataa aaacaaacat ggttgtcctt tactttgaca     4980

aagtaatgta atttttacct tatttatctg tatgaaattc cagtagttaa tttgaacatt     5040

tatttatatg acgtttgtat ttttaggtct ttaatacagt gtttctacct ctcatttgta     5100

actgcatgca ttattcttga aactaggtaa aactcactga attgttgtgt aatagccttt     5160

ttattattgc ctgtacaaat gtatattaag gtaaaataaa actgacaaag tgtttctagg     5220

gtgtagctgg gtacatatta agtggcttgt tgagccaggt acttccttag tgagtttaga     5280

gacttggcca tgaatatcct ttgtcctgcc ccaggattta gatcttggct actgtcatgc     5340

aggcttccag gaacatagac tgttttacct ccacaaccct atttgttatt agtgatactt     5400

tattttatat aatatttttt attcacagtg aaatttcatt catgttcttt cagttatcac     5460

ctgtgttatc tcagttgtag gtttattcta tcctctcctc ttcctctccc atttcttttt     5520

taacacagga tgaaacaggt tcagagaggg gaagtgattg gcctaaagtc aggaactagg     5580

caagtggtca agccatgctt tgtgactttc aagttaattc ttcttgttct tgtatattaa     5640

aggtcttggg gtagatggtg tgtgtgaaac agtgaagtct caacagcaga aaagaacaaa     5700

atgtaaattc atgaataatg gttctggtta tacttccatt atcaaggcta attaagagat     5760

tttgccttga gtatagcaat aataaacaaa tgctttatgt ttccctg                   5807


<210>  12
<211>  2589
<212>  DNA
<213>  Homo sapiens

<400>  12
atgttgagga acagcacctt caaaaacatg cagcgccggc acacaacgct gagggagaag       60

ggccgtcgcc aggccatccg gggtcccgcc tacatgttca acgagaaggg caccagtctg      120

acgcccgagg aggagcgctt cctggactcg gctgagtatg gcaacatccc ggtggtccgg      180

aaaatgctgg aggagtccaa gacccttaac ttcaactgtg tggactacat ggggcagaac      240

gctctgcagc tggccgtggg caacgagcac ctagaggtca cggagctgct gctgaagaag      300

gagaacctgg cacgggtggg ggacgcgctg ctgctggcca tcagcaaggg ctatgtgcgc      360

atcgtggagg ccatcctcaa ccacccggcc ttcgcgcagg gccagcgcct gacgctcagc      420

ccgctggaac aggagctgcg cgacgacgac ttctatgcct acgacgagga cggcacgcgc      480

ttctcccacg acatcacgcc catcatcctg gcggcgcact gccaggagta tgagatcgtg      540

cacatcctgc tgctcaaggg cgcccgcatc gagcggcccc acgactactt ctgcaagtgc      600

aatgagtgca ccgagaaaca gcggaaagac tccttcagcc actcgcgctc gcgcatgaac      660

gcctacaaag gactggcgag tgctgcctac ttgtccctgt ccagcgaaga ccctgtcctc      720

accgccctgg agctcagcaa cgagttagcc agactagcca acattgagac tgaatttaag      780

aacgattaca ggaagttatc tatgcaatgc aaggattttg tagtgggcgt gctggacctg      840

tgccgagaca cagaagaggt ggaagcaatt ttaaacggtg atgtgaactt ccaagtctgg      900

tccgaccacc accgtccaag tctgagccgg atcaaactcg ccattaaata tgaagtcaag      960

aagttcgttg ctcatcctaa ctgtcagcag caattgctta ccatgtggta tgaaaatctc     1020

tcaggcttac gtcaacagtc tatcgctgtg aaattcctgg ctgtctttgg agtctccata     1080

ggcctccctt ttctcgccat agcctattgg attgctccgt gcagcaagct aggacgaacc     1140

ctgaggagcc ctttcatgaa gtttgtagct catgcagttt cttttacaat cttcttggga     1200

ttattagttg tgaatgcatc tgaccgattt gaaggtgtta aaaccctgcc aaacgaaacc     1260

ttcacagact acccaaaaca aatcttcaga gtgaaaacca cacagttctc ctggacagaa     1320

atgctcatta tgaagtgggt cttaggaatg atttggtccg aatgcaagga aatctgggag     1380

gaggggccac gggagtacgt gctgcacttg tggaacctgc tagatttcgg gatgctgtcc     1440

atcttcgtgg cctccttcac agcacgcttc atggccttcc tgaaggccac ggaggcacag     1500

ctgtacgtgg accagcacgt gcaggacgac acgctgcaca atgtctcgct tccgccggaa     1560

gtggcatact tcacctacgc cagggacaag tggtggcctt cagaccctca gatcatatcg     1620

gaagggctct acgcgatagc cgtcgtgctg agcttctctc gcattgcata cattctgcca     1680

gccaacgaga gttttgggcc cctgcagatc tcgctaggga gaactgtgaa agatatcttc     1740

aagttcatgg tcattttcat catggtattt gtggccttca tgattgggat gttcaacctg     1800

tactcttact accgaggtgc caaatacaac ccagcgttta caacggttga agaaagtttt     1860

aaaactttgt tttggtccat attcggctta tctgaagtaa tctcagtggt gctgaaatac     1920

gaccacaaat tcatcgagaa cattggctac gttctctacg gcgtttataa cgtcaccatg     1980

gtggtagtgt tgctcaacat gctaatagcc atgataaaca actcctatca ggaaattgag     2040

gaggatgcag atgtggaatg gaagttcgcc cgagcaaaac tctggctgtc ttactttgat     2100

gaaggaagaa ctctacctgc tccttttaat ctagtgccaa gtcctaaatc attttattat     2160

ctcataatga gaatcaagat gtgcctcata aaactctgca aatctaaggc caaaagctgt     2220

gaaaatgacc ttgaaatggg catgctgaat tccaaattca agaagactcg ctaccaggct     2280

ggcatgagga attctgaaaa tctgacagca aataacactt tgagcaagcc caccagatac     2340

cagaaaatca tgaaacggct cataaaaaga tacgtcctga aagcccaggt ggacagagaa     2400

aatgacgaag tcaatgaagg cgagctgaag gaaatcaagc aagatatctc cagcctgcgc     2460

tatgagcttc ttgaggaaaa atctcaagct actggtgagc tggcagacct gattcaacaa     2520

ctcagcgaga agtttggaaa gaacttaaac aaagaccacc tgagggtgaa caagggcaaa     2580

gacatttag                                                             2589


<210>  13
<211>  3548
<212>  DNA
<213>  Homo sapiens

<400>  13
gggaagactg cactgccgcg aaggcggagg aggccggcag ccggcacccc cacactcgga       60

ccgcagccgg cgcgatgtcc accaaggtca ggaagtgcaa agaacaagca agggtgacct      120

tcccggcgcc ggaggaggag gaagacgagg gcgaggacga gggcgcggag ccgcagcgcc      180

gccgccgggg ctggaggggc gtcaacgggg ggctggagcc gcgctcggcg ccctcgcagc      240

gggagccgca cggctactgc ccgccgccct tctcccacgg gccggacctg tccatggagg      300

gaagcccatc cctgagacgc atgacagtga tgcgggagaa gggccggcgc caggctgtca      360

ggggcccggc cttcatgttc aatgaccgcg gcaccagcct caccgccgag gaggagcgct      420

tcctcgacgc cgccgagtac ggcaacatcc cagtggtgcg caagatgctg gaggagtcca      480

agacgctgaa cgtcaactgc gtggactaca tgggccagaa cgcgctgcag ctggctgtgg      540

gcaacgagca cctggaggtg accgagctgc tgctcaagaa ggagaacctg gcgcgcattg      600

gcgacgccct gctgctcgcc atcagcaagg gctacgtgcg catcgtagag gccatcctca      660

accaccctgg cttcgcggcc agcaagcgtc tcactctgag cccctgtgag caggagctgc      720

aggacgacga cttctacgct tacgacgagg acggcacgcg cttctcgccg gacatcaccc      780

ccatcatcct ggcggcgcac tgccagaaat acgaagtggt gcacatgctg ctgatgaagg      840

gtgccaggat cgagcggccg cacgactatt tctgcaagtg cggggactgc atggagaagc      900

agaggcacga ctccttcagc cactcacgct cgaggatcaa tgcctacaag gggctggcca      960

gcccggctta cctctcattg tccagcgagg acccggtgct tacggcccta gagctcagca     1020

acgagctggc caagctggcc aacatagaga aggagttcaa gaatgactat cggaagctct     1080

ccatgcaatg caaagacttt gtagtgggtg tgctggatct ctgccgagac tcagaagagg     1140

tagaagccat tctgaatgga gatctggaat cagcagagcc tctggaggta cacaggcaca     1200

aagcttcatt aagtcgtgtc aaacttgcca ttaagtatga agtcaaaaag tttgtggctc     1260

atcccaactg ccagcagcag ctcttgacga tctggtatga gaacctctca ggcctaaggg     1320

agcagaccat agctatcaag tgtctcgttg tgctggtcgt ggccctgggc cttccattcc     1380

tggccattgg ctactggatc gcaccttgca gcaggctggg gaaaattctg cgaagccctt     1440

ttatgaagtt tgtagcacat gcagcttctt tcatcatctt cctgggtctg cttgtgttca     1500

atgcctcaga caggttcgaa ggcatcacca cgctgcccaa tatcacagtt actgactatc     1560

ccaaacagat cttcagggtg aaaaccaccc agtttacatg gactgaaatg ctaattatgg     1620

tctgggttct tggaatgatg tggtctgaat gtaaagagct ctggctggaa ggacctaggg     1680

aatacatttt gcagttgtgg aatgtgcttg actttgggat gctgtccatc ttcattgctg     1740

ctttcacagc cagattccta gctttccttc aggcaacgaa ggcacaacag tatgtggaca     1800

gttacgtcca agagagtgac ctcagtgaag tgacactccc accagagata cagtatttca     1860

cttatgctag agataaatgg ctcccttctg accctcagat tatatctgaa ggcctttatg     1920

ccatagctgt tgtgctcagc ttctctcgga ttgcgtacat cctccctgca aatgagagct     1980

ttggccccct gcagatctct cttggaagga ctgtaaagga catattcaag ttcatggtcc     2040

tctttattat ggtgtttttt gcctttatga ttggcatgtt catactttat tcttactacc     2100

ttggggctaa agttaatgct gcttttacca ctgtagaaga aagtttcaag actttatttt     2160

ggtcaatatt tgggttgtct gaagtgactt ccgttgtgct caaatatgat cacaaattca     2220

tagaaaatat tggatacgtt ctttatggaa tatacaatgt aactatggtg gtcgttttac     2280

tcaacatgct aattgctatg attaatagct catatcaaga aattgaggat gacagtgatg     2340

tagaatggaa gtttgctcgt tcaaaacttt ggttatccta ttttgatgat ggaaaaacat     2400

tacctccacc tttcagtcta gttcctagtc caaaatcatt tgtttatttc atcatgcgaa     2460

ttgttaactt tcccaaatgc agaaggagaa ggcttcagaa ggatatagaa atgggaatgg     2520

gtaactcaaa gtccaggtta aacctcttca ctcagtctaa ctcaagagtt tttgaatcac     2580

acagttttaa cagcattctc aatcagccaa cacgttatca gcagataatg aaaagactta     2640

taaagcggta tgttttgaaa gcacaagtag acaaagaaaa tgatgaagtt aatgaaggtg     2700

aattaaaaga aatcaagcaa gatatctcca gccttcgtta tgaacttttg gaagacaaga     2760

gccaagcaac tgaggaatta gccattctaa ttcataaact tagtgagaaa ctgaatccca     2820

gcatgctgag atgtgaatga tgcagcaacc tggatttggc tttgactata gcacaaatgt     2880

gggcaataat atttctaagt atgaaatact tgaaaaacta tgatgtaaat ttttagtatt     2940

aactaccttt atcatgtgaa cctttaaaag ttagctctta atggttttat tgttttatca     3000

catgaaaatg cattttattt gtctgctttg acattacagt ggcataccat tgtgttgaaa     3060

agcccaatat tactatatta ttgaaacttt tattcatttt agagtaaact ccacatcttt     3120

gcactacctg tttgcctcca agagactatc agttccttgg ggacagggac catgtcttat     3180

tcatctttgt gtctccagca tctagtacag tgcctggtat atagtaggtg ctcaataaat     3240

gttgaaacca actgaactgc caacaaaata aaaataaaaa gtcttcacta tgtagcatac     3300

cttcccttgt ccaagttctg aagaggtttt tttttttttt ttttaataga aactgaagac     3360

attttacaac cagctatgac ttggtaagac attcttagaa ttttaggtgt cactgataat     3420

cctagaacca ctgagcccca agtgaagaat ttaacaacaa aatgggttaa tgaaaaatat     3480

aattacattg tatatttaag tttcatagaa ttatttaaaa caacacatta aagatttttc     3540

taaaatat                                                              3548


<210>  14
<211>  3330
<212>  DNA
<213>  Homo sapiens

<400>  14
gggccctgac atgtgaaagg aaggaatgtg ccctaatatt ctacagttgt tttatcgttg       60

ctactgatta ggtccatgga gggaagccca tccctgagac gcatgacagt gatgcgggag      120

aagggccggc gccaggctgt caggggcccg gccttcatgt tcaatgaccg cggcaccagc      180

ctcaccgccg aggaggagcg cttcctcgac gccgccgagt acggcaacat cccagtggtg      240

cgcaagatgc tggaggagtc caagacgctg aacgtcaact gcgtggacta catgggccag      300

aacgcgctgc agctggctgt gggcaacgag cacctggagg tgaccgagct gctgctcaag      360

aaggagaacc tggcgcgcat tggcgacgcc ctgctgctcg ccatcagcaa gggctacgtg      420

cgcatcgtag aggccatcct caaccaccct ggcttcgcgg ccagcaagcg tctcactctg      480

agcccctgtg agcaggagct gcaggacgac gacttctacg cttacgacga ggacggcacg      540

cgcttctcgc cggacatcac ccccatcatc ctggcggcgc actgccagaa atacgaagtg      600

gtgcacatgc tgctgatgaa gggtgccagg atcgagcggc cgcacgacta tttctgcaag      660

tgcggggact gcatggagaa gcagaggcac gactccttca gccactcacg ctcgaggatc      720

aatgcctaca aggggctggc cagcccggct tacctctcat tgtccagcga ggacccggtg      780

cttacggccc tagagctcag caacgagctg gccaagctgg ccaacataga gaaggagttc      840

aagaatgact atcggaagct ctccatgcaa tgcaaagact ttgtagtggg tgtgctggat      900

ctctgccgag actcagaaga ggtagaagcc attctgaatg gagatctgga atcagcagag      960

cctctggagg tacacaggca caaagcttca ttaagtcgtg tcaaacttgc cattaagtat     1020

gaagtcaaaa agtttgtggc tcatcccaac tgccagcagc agctcttgac gatctggtat     1080

gagaacctct caggcctaag ggagcagacc atagctatca agtgtctcgt tgtgctggtc     1140

gtggccctgg gccttccatt cctggccatt ggctactgga tcgcaccttg cagcaggctg     1200

gggaaaattc tgcgaagccc ttttatgaag tttgtagcac atgcagcttc tttcatcatc     1260

ttcctgggtc tgcttgtgtt caatgcctca gacaggttcg aaggcatcac cacgctgccc     1320

aatatcacag ttactgacta tcccaaacag atcttcaggg tgaaaaccac ccagtttaca     1380

tggactgaaa tgctaattat ggtctgggtt cttggaatga tgtggtctga atgtaaagag     1440

ctctggctgg aaggacctag ggaatacatt ttgcagttgt ggaatgtgct tgactttggg     1500

atgctgtcca tcttcattgc tgctttcaca gccagattcc tagctttcct tcaggcaacg     1560

aaggcacaac agtatgtgga cagttacgtc caagagagtg acctcagtga agtgacactc     1620

ccaccagaga tacagtattt cacttatgct agagataaat ggctcccttc tgaccctcag     1680

attatatctg aaggccttta tgccatagct gttgtgctca gcttctctcg gattgcgtac     1740

atcctccctg caaatgagag ctttggcccc ctgcagatct ctcttggaag gactgtaaag     1800

gacatattca agttcatggt cctctttatt atggtgtttt ttgcctttat gattggcatg     1860

ttcatacttt attcttacta ccttggggct aaagttaatg ctgcttttac cactgtagaa     1920

gaaagtttca agactttatt ttggtcaata tttgggttgt ctgaagtgac ttccgttgtg     1980

ctcaaatatg atcacaaatt catagaaaat attggatacg ttctttatgg aatatacaat     2040

gtaactatgg tggtcgtttt actcaacatg ctaattgcta tgattaatag ctcatatcaa     2100

gaaattgagg atgacagtga tgtagaatgg aagtttgctc gttcaaaact ttggttatcc     2160

tattttgatg atggaaaaac attacctcca cctttcagtc tagttcctag tccaaaatca     2220

tttgtttatt tcatcatgcg aattgttaac tttcccaaat gcagaaggag aaggcttcag     2280

aaggatatag aaatgggaat gggtaactca aagtccaggt taaacctctt cactcagtct     2340

aactcaagag tttttgaatc acacagtttt aacagcattc tcaatcagcc aacacgttat     2400

cagcagataa tgaaaagact tataaagcgg tatgttttga aagcacaagt agacaaagaa     2460

aatgatgaag ttaatgaagg tgaattaaaa gaaatcaagc aagatatctc cagccttcgt     2520

tatgaacttt tggaagacaa gagccaagca actgaggaat tagccattct aattcataaa     2580

cttagtgaga aactgaatcc cagcatgctg agatgtgaat gatgcagcaa cctggatttg     2640

gctttgacta tagcacaaat gtgggcaata atatttctaa gtatgaaata cttgaaaaac     2700

tatgatgtaa atttttagta ttaactacct ttatcatgtg aacctttaaa agttagctct     2760

taatggtttt attgttttat cacatgaaaa tgcattttat ttgtctgctt tgacattaca     2820

gtggcatacc attgtgttga aaagcccaat attactatat tattgaaact tttattcatt     2880

ttagagtaaa ctccacatct ttgcactacc tgtttgcctc caagagacta tcagttcctt     2940

ggggacaggg accatgtctt attcatcttt gtgtctccag catctagtac agtgcctggt     3000

atatagtagg tgctcaataa atgttgaaac caactgaact gccaacaaaa taaaaataaa     3060

aagtcttcac tatgtagcat accttccctt gtccaagttc tgaagaggtt tttttttttt     3120

ttttttaata gaaactgaag acattttaca accagctatg acttggtaag acattcttag     3180

aattttaggt gtcactgata atcctagaac cactgagccc caagtgaaga atttaacaac     3240

aaaatgggtt aatgaaaaat ataattacat tgtatattta agtttcatag aattatttaa     3300

aacaacacat taaagatttt tctaaaatat                                      3330


<210>  15
<211>  2769
<212>  DNA
<213>  Homo sapiens

<400>  15
gctcatttgt aggctgaact aatgactgcc gccataagaa gacagagaga actgagtatc       60

ctcccaaagg tgacactgga agcaatgaac accacagtga tgcaaggctt caacagatct      120

gagcggtgcc ccagagacac tcggatagta cagctggtat tcccagccct ctacacagtg      180

gttttcttga ccggcatcct gctgaatact ttggctctgt gggtgtttgt tcacatcccc      240

agctcctcca ccttcatcat ctacctcaaa aacactttgg tggccgactt gataatgaca      300

ctcatgcttc ctttcaaaat cctctctgac tcacacctgg caccctggca gctcagagct      360

tttgtgtgtc gtttttcttc ggtgatattt tatgagacca tgtatgtggg catcgtgctg      420

ttagggctca tagcctttga cagattcctc aagatcatca gacctttgag aaatattttt      480

ctaaaaaaac ctgtttttgc aaaaacggtc tcaatcttca tctggttctt tttgttcttc      540

atctccctgc caaatacgat cttgagcaac aaggaagcaa caccatcgtc tgtgaaaaag      600

tgtgcttcct taaaggggcc tctggggctg aaatggcatc aaatggtaaa taacatatgc      660

cagtttattt tctggactgt ttttatccta atgcttgtgt tttatgtggt tattgcaaaa      720

aaagtatatg attcttatag aaagtccaaa agtaaggaca gaaaaaacaa caaaaagctg      780

gaaggcaaag tatttgttgt cgtggctgtc ttctttgtgt gttttgctcc atttcatttt      840

gccagagttc catatactca cagtcaaacc aacaataaga ctgactgtag actgcaaaat      900

caactgttta ttgctaaaga aacaactctc tttttggcag caactaacat ttgtatggat      960

cccttaatat acatattctt atgtaaaaaa ttcacagaaa agctaccatg tatgcaaggg     1020

agaaagacca cagcatcaag ccaagaaaat catagcagtc agacagacaa cataacctta     1080

ggctgacaac tgtacatagg gttaacttct atttattgat gagacttccg tagataatgt     1140

ggaaatcaaa tttaaccaag aaaaaaagat tggaacaaat gctctcttac attttattat     1200

cctcgtgtac agaaaagatt atataaaatt taaatccaca tagatctatt cataagctga     1260

atgaaccatt actaagagaa tgcaacagga tacaaatggc cactagaggt cattatttct     1320

ttctttcttt tttttttttt ttaatttcaa gagcatttca ctttaacatt ttggaaaaga     1380

ctaaggagaa acgtatatcc ctacaaacct cccctccaaa caccttctca cattcttttc     1440

cacaattcac ataacactac tgcttttgtg ccccttaaat gtagatatgt gctgaaagaa     1500

aaaaaaaacg cccaactctt gaagtccatt gctgaaaact gcagccaggg gttgaaaggg     1560

atgcagactt gaagagtctg aggaactgaa gtgggtcagc aagacctctg aaatcctggg     1620

taaaggattt tctccttaca attacaaaca gcctctttca cattacaata atataccata     1680

ggaggcacaa gcaccattat taagccactt tgcttacacc ttaagtgtgt acaattcaag     1740

tgtgagaatg ctgtgttaac tattctttgg aattctcctt ctgtccagca aatactctaa     1800

tgatggttaa acatggcacc tactcagcaa tgccttcctg gaccacaacc cctatccccc     1860

tgccccaccc tcctcattaa aaacaaatac ttctactgtt tgggtgtgtg atagggttct     1920

caatgcagat ctcccttttc tagttagcta tattcttgac tgcatccgct aaaaatgtta     1980

aagcttcttg agagacagac atgccagatt ttcttggtat ctcccataat acgacctaca     2040

gtccatggtc tacagatgtt ttaaatagaa ttgctattct cgatacatac aaagacgtaa     2100

ttgctgaccc acaatcagta acatccatat tgagagattt ttcaaaggat ggtgaccctg     2160

cttgtattta tttaccttgg tattttttct tgcatccttc tgtgattcaa aaaagtaaaa     2220

tgtggctttc tgaaatgatg gataagagtc tacatcttct agaaaaaata cataaaggag     2280

tagttaagct ctgtaaatgt gccacgagct ccaacacgac catcgtaggg tgaagcccac     2340

gttttcttcc atggcctcaa aggccctaga acttgcctac ctttctggcc ttacctccta     2400

gctacttatc catctcttga actttatact cttgtataaa tttctaactt tcagaaaatg     2460

ccatactctg ttttggcacc acacatgtat atttccccct ggtacacttg gaagactctt     2520

atccatctgt gaaaccctat gttgtcatca cttggtccat gaaatattac ctggccaata     2580

tcccaccatc acctcaaacc caatcacccc ctcctctgta tgctgtcaca cctatattat     2640

taaacttatc acattgcatt gtaattactt cctgaccttt gtatctactc ttttagtaac     2700

tgatgtatat atctgaaagg agagattgtt tcattgtgca atcaataaat gtttgataaa     2760

ataaagccc                                                             2769


<210>  16
<211>  2858
<212>  DNA
<213>  Homo sapiens

<400>  16
aacagtattt tccttttcaa cacatctatt gaaagtgttg gataaatgca ggatgttaat       60

atgctataaa cataaagtct gtttttaaaa aatagcattt gaaaatcatg aagggctttt      120

tgttttcttt tgtttgtata tatgtttatt ggtaacaggt gacactggaa gcaatgaaca      180

ccacagtgat gcaaggcttc aacagatctg agcggtgccc cagagacact cggatagtac      240

agctggtatt cccagccctc tacacagtgg ttttcttgac cggcatcctg ctgaatactt      300

tggctctgtg ggtgtttgtt cacatcccca gctcctccac cttcatcatc tacctcaaaa      360

acactttggt ggccgacttg ataatgacac tcatgcttcc tttcaaaatc ctctctgact      420

cacacctggc accctggcag ctcagagctt ttgtgtgtcg tttttcttcg gtgatatttt      480

atgagaccat gtatgtgggc atcgtgctgt tagggctcat agcctttgac agattcctca      540

agatcatcag acctttgaga aatatttttc taaaaaaacc tgtttttgca aaaacggtct      600

caatcttcat ctggttcttt ttgttcttca tctccctgcc aaatacgatc ttgagcaaca      660

aggaagcaac accatcgtct gtgaaaaagt gtgcttcctt aaaggggcct ctggggctga      720

aatggcatca aatggtaaat aacatatgcc agtttatttt ctggactgtt tttatcctaa      780

tgcttgtgtt ttatgtggtt attgcaaaaa aagtatatga ttcttataga aagtccaaaa      840

gtaaggacag aaaaaacaac aaaaagctgg aaggcaaagt atttgttgtc gtggctgtct      900

tctttgtgtg ttttgctcca tttcattttg ccagagttcc atatactcac agtcaaacca      960

acaataagac tgactgtaga ctgcaaaatc aactgtttat tgctaaagaa acaactctct     1020

ttttggcagc aactaacatt tgtatggatc ccttaatata catattctta tgtaaaaaat     1080

tcacagaaaa gctaccatgt atgcaaggga gaaagaccac agcatcaagc caagaaaatc     1140

atagcagtca gacagacaac ataaccttag gctgacaact gtacataggg ttaacttcta     1200

tttattgatg agacttccgt agataatgtg gaaatcaaat ttaaccaaga aaaaaagatt     1260

ggaacaaatg ctctcttaca ttttattatc ctcgtgtaca gaaaagatta tataaaattt     1320

aaatccacat agatctattc ataagctgaa tgaaccatta ctaagagaat gcaacaggat     1380

acaaatggcc actagaggtc attatttctt tctttctttt tttttttttt taatttcaag     1440

agcatttcac tttaacattt tggaaaagac taaggagaaa cgtatatccc tacaaacctc     1500

ccctccaaac accttctcac attcttttcc acaattcaca taacactact gcttttgtgc     1560

cccttaaatg tagatatgtg ctgaaagaaa aaaaaaacgc ccaactcttg aagtccattg     1620

ctgaaaactg cagccagggg ttgaaaggga tgcagacttg aagagtctga ggaactgaag     1680

tgggtcagca agacctctga aatcctgggt aaaggatttt ctccttacaa ttacaaacag     1740

cctctttcac attacaataa tataccatag gaggcacaag caccattatt aagccacttt     1800

gcttacacct taagtgtgta caattcaagt gtgagaatgc tgtgttaact attctttgga     1860

attctccttc tgtccagcaa atactctaat gatggttaaa catggcacct actcagcaat     1920

gccttcctgg accacaaccc ctatccccct gccccaccct cctcattaaa aacaaatact     1980

tctactgttt gggtgtgtga tagggttctc aatgcagatc tcccttttct agttagctat     2040

attcttgact gcatccgcta aaaatgttaa agcttcttga gagacagaca tgccagattt     2100

tcttggtatc tcccataata cgacctacag tccatggtct acagatgttt taaatagaat     2160

tgctattctc gatacataca aagacgtaat tgctgaccca caatcagtaa catccatatt     2220

gagagatttt tcaaaggatg gtgaccctgc ttgtatttat ttaccttggt attttttctt     2280

gcatccttct gtgattcaaa aaagtaaaat gtggctttct gaaatgatgg ataagagtct     2340

acatcttcta gaaaaaatac ataaaggagt agttaagctc tgtaaatgtg ccacgagctc     2400

caacacgacc atcgtagggt gaagcccacg ttttcttcca tggcctcaaa ggccctagaa     2460

cttgcctacc tttctggcct tacctcctag ctacttatcc atctcttgaa ctttatactc     2520

ttgtataaat ttctaacttt cagaaaatgc catactctgt tttggcacca cacatgtata     2580

tttccccctg gtacacttgg aagactctta tccatctgtg aaaccctatg ttgtcatcac     2640

ttggtccatg aaatattacc tggccaatat cccaccatca cctcaaaccc aatcaccccc     2700

tcctctgtat gctgtcacac ctatattatt aaacttatca cattgcattg taattacttc     2760

ctgacctttg tatctactct tttagtaact gatgtatata tctgaaagga gagattgttt     2820

cattgtgcaa tcaataaatg tttgataaaa taaagccc                             2858


<210>  17
<211>  5621
<212>  DNA
<213>  Homo sapiens

<400>  17
aagaaaatcc tgcttgacaa aaaccgtcac ttaggaaaag atgtcctttc gggcagccag       60

gctcagcatg aggaacagaa ggaatgacac tctggacagc acccggaccc tgtactccag      120

cgcgtctcgg agcacagact tgtcttacag tgaaagcgac ttggtgaatt ttattcaagc      180

aaattttaag aaacgagaat gtgtcttctt taccaaagat tccaaggcca cggagaatgt      240

gtgcaagtgt ggctatgccc agagccagca catggaaggc acccagatca accaaagtga      300

gaaatggaac tacaagaaac acaccaagga atttcctacc gacgcctttg gggatattca      360

gtttgagaca ctggggaaga aagggaagta tatacgtctg tcctgcgaca cggacgcgga      420

aatcctttac gagctgctga cccagcactg gcacctgaaa acacccaacc tggtcatttc      480

tgtgaccggg ggcgccaaga acttcgccct gaagccgcgc atgcgcaaga tcttcagccg      540

gctcatctac atcgcgcagt ccaaaggtgc ttggattctc acgggaggca cccattatgg      600

cctgatgaag tacatcgggg aggtggtgag agataacacc atcagcagga gttcagagga      660

gaatattgtg gccattggca tagcagcttg gggcatggtc tccaaccggg acaccctcat      720

caggaattgc gatgctgagg gctatttttt agcccagtac cttatggatg acttcacaag      780

agatccactg tatatcctgg acaacaacca cacacatttg ctgctcgtgg acaatggctg      840

tcatggacat cccactgtcg aagcaaagct ccggaatcag ctagagaagt atatctctga      900

gcgcactatt caagattcca actatggtgg caagatcccc attgtgtgtt ttgcccaagg      960

aggtggaaaa gagactttga aagccatcaa tacctccatc aaaaataaaa ttccttgtgt     1020

ggtggtggaa ggctcgggcc agatcgctga tgtgatcgct agcctggtgg aggtggagga     1080

tgccctgaca tcttctgccg tcaaggagaa gctggtgcgc tttttacccc gcacggtgtc     1140

ccggctgcct gaggaggaga ctgagagttg gatcaaatgg ctcaaagaaa ttctcgaatg     1200

ttctcaccta ttaacagtta ttaaaatgga agaagctggg gatgaaattg tgagcaatgc     1260

catctcctac gctctataca aagccttcag caccagtgag caagacaagg ataactggaa     1320

tgggcagctg aagcttctgc tggagtggaa ccagctggac ttagccaatg atgagatttt     1380

caccaatgac cgccgatggg agtctgctga ccttcaagaa gtcatgttta cggctctcat     1440

aaaggacaga cccaagtttg tccgcctctt tctggagaat ggcttgaacc tacggaagtt     1500

tctcacccat gatgtcctca ctgaactctt ctccaaccac ttcagcacgc ttgtgtaccg     1560

gaatctgcag atcgccaaga attcctataa tgatgccctc ctcacgtttg tctggaaact     1620

ggttgcgaac ttccgaagag gcttccggaa ggaagacaga aatggccggg acgagatgga     1680

catagaactc cacgacgtgt ctcctattac tcggcacccc ctgcaagctc tcttcatctg     1740

ggccattctt cagaataaga aggaactctc caaagtcatt tgggagcaga ccaggggctg     1800

cactctggca gccctgggag ccagcaagct tctgaagact ctggccaaag tgaagaacga     1860

catcaatgct gctggggagt ccgaggagct ggctaatgag tacgagaccc gggctgttga     1920

gctgttcact gagtgttaca gcagcgatga agacttggca gaacagctgc tggtctattc     1980

ctgtgaagct tggggtggaa gcaactgtct ggagctggcg gtggaggcca cagaccagca     2040

tttcatcgcc cagcctgggg tccagaattt tctttctaag caatggtatg gagagatttc     2100

ccgagacacc aagaactgga agattatcct gtgtctgttt attataccct tggtgggctg     2160

tggctttgta tcatttagga agaaacctgt cgacaagcac aagaagctgc tttggtacta     2220

tgtggcgttc ttcacctccc ccttcgtggt cttctcctgg aatgtggtct tctacatcgc     2280

cttcctcctg ctgtttgcct acgtgctgct catggatttc cattcggtgc cacacccccc     2340

cgagctggtc ctgtactcgc tggtctttgt cctcttctgt gatgaagtga gacagtggta     2400

cgtaaatggg gtgaattatt ttactgacct gtggaatgtg atggacacgc tggggctttt     2460

ttacttcata gcaggaattg tatttcggct ccactcttct aataaaagct ctttgtattc     2520

tggacgagtc attttctgtc tggactacat tattttcact ctaagattga tccacatttt     2580

tactgtaagc agaaacttag gacccaagat tataatgctg cagaggatgc tgatcgatgt     2640

gttcttcttc ctgttcctct ttgcggtgtg gatggtggcc tttggcgtgg ccaggcaagg     2700

gatccttagg cagaatgagc agcgctggag gtggatattc cgttcggtca tctacgagcc     2760

ctacctggcc atgttcggcc aggtgcccag tgacgtggat ggtaccacgt atgactttgc     2820

ccactgcacc ttcactggga atgagtccaa gccactgtgt gtggagctgg atgagcacaa     2880

cctgccccgg ttccccgagt ggatcaccat ccccctggtg tgcatctaca tgttatccac     2940

caacatcctg ctggtcaacc tgctggtcgc catgtttggc tacacggtgg gcaccgtcca     3000

ggagaacaat gaccaggtct ggaagttcca gaggtacttc ctggtgcagg agtactgcag     3060

ccgcctcaat atccccttcc ccttcatcgt cttcgcttac ttctacatgg tggtgaagaa     3120

gtgcttcaag tgttgctgca aggagaaaaa catggagtct tctgtctgct gtttcaaaaa     3180

tgaagacaat gagactctgg catgggaggg tgtcatgaag gaaaactacc ttgtcaagat     3240

caacacaaaa gccaacgaca cctcagagga aatgaggcat cgatttagac aactggatac     3300

aaagcttaat gatctcaagg gtcttctgaa agagattgct aataaaatca aataaaactg     3360

tatgaactct aatggagaaa aatctaatta tagcaagatc atattaagga atgctgatga     3420

acaattttgc tatcgactac taaatgagag attttcagac ccctgggtac atggtggatg     3480

attttaaatc accctagtgt gctgagacct tgagaataaa gtgtgtgatt ggtttcatac     3540

ttgaagacgg atataaagga agaatatttc ctttatgtgt ttctccagaa tggtgcctgt     3600

ttctctctgt gtctcaatgc ctgggactgg aggttgatag tttaagtgtg ttcttaccgc     3660

ctcctttttc ctttaatctt atttttgatg aacacatata taggagaaca tctatcctat     3720

gaataagaac ctggtcatgc tttactcctg tattgttatt ttgttcattt ccaattgatt     3780

ctctactttt cccttttttg tattatgtga ctaattagtt ggcatattgt taaaagtctc     3840

tcaaattagg ccagattcta aaacatgctg cagcaagagg accccgctct cttcaggaaa     3900

agtgttttca tttctcagga tgcttcttac ctgtcagagg aggtgacaag gcagtctctt     3960

gctctcttgg actcaccagg ctcctattga aggaaccacc cccattccta aatatgtgaa     4020

aagtcgccca aaatgcaacc ttgaaaggca ctactgactt tgttcttatt ggatactcct     4080

cttattattt ttccattaaa aataatagct ggctattata gaaaatttag accatacaga     4140

gatgtagaaa gaacataaat tgtccccatt accttaaggt aatcactgct aacaatttct     4200

ggatggtttt tcaagtctat tttttttcta tgtatgtctc aattctcttt caaaatttta     4260

cagaatgtta tcatactaca tatatacttt ttatgtaagc tttttcactt agtattttat     4320

caaatatgtt tttattatat tcatagcctt cttaaacatt atatcaataa ttgcataata     4380

ggcaacctct agcgattacc ataattttgc tcattgaagg ctatctccag ttgatcattg     4440

ggatgagcat ctttgtgcat gaatcctatt gctgtatttg ggaaaatttt ccaaggttag     4500

attccaataa atatctattt attattaaat attaaaatat ctatttatta ttaaaaccat     4560

ttataaggct ttttcataaa tgtatagcaa ataggaatta ttaacttgag cataagatat     4620

gagatacatg aacctgaact attaaaataa aatattatat ttaaccctta gtttaagaag     4680

aagtcaatat gcttatttaa atattatgga tggtgggcag atcacttgag gtcaggagtt     4740

cgagaccagc ctggccaaca tggcaaaacc acatctctac taaaaataaa aaaattagct     4800

gggtgtggtg gtgcactcct gtaatcccag ctactcagaa ggctgaggta caagaattgc     4860

tggaacctgg gaggcggagg ttgcagtgaa ccaagattgc accactgcac tccagccggg     4920

gtgacagagt gagactccga ctgaaaataa ataaataaat aaataaataa ataaataaat     4980

attatggatg gtgaagggaa tggtatagaa ttggagagat tatcttactg aacacctgta     5040

gtcccagctt tctctggaag tggtcgtatt tgagcaggat gtgcacaagg caattgaaat     5100

gcccataatt agtttctcag ctttgaatac actataaact cactggctga aggaggaaat     5160

tttagaagga agctactaaa agatctaatt tgaaaaacta caaaagcatt aactaaaaaa     5220

gtttattttc cttttgtctg ggcagtagtg aaaataacta ctcacaacat tcactatgtt     5280

tgcaaggaat taacacaaat aaaagatgcc tttttactta aacaccaaga cagaaaactt     5340

gcccaatact gagaagcaac ttgcattaga gagggaactg ttaaatgttt tcaacccagt     5400

tcatctggtg gatgtttttg caggttactc tgagaatttt gcttatgaaa aatcattatt     5460

tttagtgtag ttcacaataa tgtattgaac atacttctaa tcaaaggtgc tatgtccttg     5520

tgtatggtac taaatgtgtc ctgtgtactt ttgcacaact gagaatcctg cagcttggtt     5580

taatgagtgt gttcatgaaa taaataatgg aggaattgtc a                         5621


<210>  18
<211>  6364
<212>  DNA
<213>  Homo sapiens

<400>  18
ctgggataga agcggcagga gcagcgttgg caccggcgaa ccatggctgg gattttctat       60

ttcgccctat tttcgtgtct cttcgggatt tgcgacgctg tcacaggttc cagggtatac      120

cccgcgaatg aagttacctt attggattcc agatctgttc agggagaact tgggtggata      180

gcaagccctc tggaaggagg gtgggaggaa gtgagtatca tggatgaaaa aaatacacca      240

atccgaacct accaagtgtg caatgtgatg gaacccagcc agaataactg gctacgaact      300

gattggatca cccgagaagg ggctcagagg gtgtatattg agattaaatt caccttgagg      360

gactgcaata gtcttccggg cgtcatgggg acttgcaagg agacgtttaa cctgtactac      420

tatgaatcag acaacgacaa agagcgtttc atcagagaga accagtttgt caaaattgac      480

accattgctg ctgatgagag cttcacccaa gtggacattg gtgacagaat catgaagctg      540

aacaccgaga tccgggatgt agggccatta agcaaaaagg ggttttacct ggcttttcag      600

gatgtggggg cctgcatcgc cctggtatca gtccgtgtgt tctataaaaa gtgtccactc      660

acagtccgca atctggccca gtttcctgac accatcacag gggctgatac gtcttccctg      720

gtggaagttc gaggctcctg tgtcaacaac tcagaagaga aagatgtgcc aaaaatgtac      780

tgtggggcag atggtgaatg gctggtaccc attggcaact gcctatgcaa cgctgggcat      840

gaggagcgga gcggagaatg ccaagcttgc aaaattggat attacaaggc tctctccacg      900

gatgccacct gtgccaagtg cccaccccac agctactctg tctgggaagg agccacctcg      960

tgcacctgtg accgaggctt tttcagagct gacaacgatg ctgcctctat gccctgcacc     1020

cgtccaccat ctgctcccct gaacttgatt tcaaatgtca acgagacatc tgtgaacttg     1080

gaatggagta gccctcagaa tacaggtggc cgccaggaca tttcctataa tgtggtatgc     1140

aagaaatgtg gagctggtga ccccagcaag tgccgaccct gtggaagtgg ggtccactac     1200

accccacagc agaatggctt gaagaccacc aaagtctcca tcactgacct cctagctcat     1260

accaattaca cctttgaaat ctgggctgtg aatggagtgt ccaaatataa ccctaaccca     1320

gaccaatcag tttctgtcac tgtgaccacc aaccaagcag caccatcatc cattgctttg     1380

gtccaggcta aagaagtcac aagatacagt gtggcactgg cttggctgga accagatcgg     1440

cccaatgggg taatcctgga atatgaagtc aagtattatg agaaggatca gaatgagcga     1500

agctatcgta tagttcggac agctgccagg aacacagata tcaaaggcct gaaccctctc     1560

acttcctatg ttttccacgt gcgagccagg acagcagctg gctatggaga cttcagtgag     1620

cccttggagg ttacaaccaa cacagtgcct tcccggatca ttggagatgg ggctaactcc     1680

acagtccttc tggtctctgt ctcgggcagt gtggtgctgg tggtaattct cattgcagct     1740

tttgtcatca gccggagacg gagtaaatac agtaaagcca aacaagaagc ggatgaagag     1800

aaacatttga atcaaggtgt aagaacatat gtggacccct ttacgtacga agatcccaac     1860

caagcagtgc gagagtttgc caaagaaatt gacgcatcct gcattaagat tgaaaaagtt     1920

ataggagttg gtgaatttgg tgaggtatgc agtgggcgtc tcaaagtgcc tggcaagaga     1980

gagatctgtg tggctatcaa gactctgaaa gctggttata cagacaaaca gaggagagac     2040

ttcctgagtg aggccagcat catgggacag tttgaccatc cgaacatcat tcacttggaa     2100

ggcgtggtca ctaaatgtaa accagtaatg atcataacag agtacatgga gaatggctcc     2160

ttggatgcat tcctcaggaa aaatgatggc agatttacag tcattcagct ggtgggcatg     2220

cttcgtggca ttgggtctgg gatgaagtat ttatctgata tgagctatgt gcatcgtgat     2280

ctggccgcac ggaacatcct ggtgaacagc aacttggtct gcaaagtgtc tgattttggc     2340

atgtcccgag tgcttgagga tgatccggaa gcagcttaca ccaccagggg tggcaagatt     2400

cctatccggt ggactgcgcc agaagcaatt gcctatcgta aattcacatc agcaagtgat     2460

gtatggagct atggaatcgt tatgtgggaa gtgatgtcgt acggggagag gccctattgg     2520

gatatgtcca atcaagatgt gattaaagcc attgaggaag gctatcggtt accccctcca     2580

atggactgcc ccattgcgct ccaccagctg atgctagact gctggcagaa ggagaggagc     2640

gacaggccta aatttgggca gattgtcaac atgttggaca aactcatccg caaccccaac     2700

agcttgaaga ggacagggac ggagagctcc agacctaaca ctgccttgtt ggatccaagc     2760

tcccctgaat tctctgctgt ggtatcagtg ggcgattggc tccaggccat taaaatggac     2820

cggtataagg ataacttcac agctgctggt tataccacac tagaggctgt ggtgcacgtg     2880

aaccaggagg acctggcaag aattggtatc acagccatca cgcaccagaa taagattttg     2940

agcagtgtcc aggcaatgcg aacccaaatg cagcagatgc acggcagaat ggttcccgtc     3000

tgagccagta ctgaataaac tcaaaactct tgaaattagt ttacctcatc catgcacttt     3060

aattgaagaa ctgcactttt tttacttcgt cttcgccctc tgaaattaaa gaaatgaaaa     3120

aaaaaaacaa tatctgcagc gttgcttggt gcacagattg ctgaaactgt ggggcttaca     3180

gaaatgactg ccggtcattt gaatgagacc tggaacaaat cgtttctcag aagtactttt     3240

ctgttcatca ccagtctgta aaatacatgt acctatagaa atagaacact gcctctgagt     3300

tttgatgctg tatttgctgc cagacactga gcttctgaga catccctgat tctctctcca     3360

tttggaatta caaccattgt attttgtttg tggcataaat tacagtcatc tgtctttcac     3420

tggaatgaag accatgccta ggaacatttt ttaaggactc agctgtggct tttagggctt     3480

ggttcatacc atgggggaaa aaaaagtcct aggagaaagc gacgtggctc attagtgttg     3540

cctcttcagt gctcaagccg cctggtggat tcctatgaca cagggggcct ggaaagaaag     3600

ggaaagtgga tttaaaatat atatatacgt aacccaagcc ccataacccc taactggaca     3660

aatgaggtct gtttctttgg gcctgaggct gtgccatata aagtcttatt ttgggacttt     3720

acaaacttgt cctaactatc ttgtggatag tgggctgtga caatctggaa tagagaacgt     3780

tcacacttcg ctcctttaaa gaagcgaccc cagatctgca agggagtaga ttctgctatc     3840

ttggcctcac agcccttcct gttgattaca aagcccgtgg aagaaaacag aacacaccct     3900

cctcagttcc gtctaaatgt gtttcttctg cttcaattac accagttctg gggcaaagac     3960

actgatgaaa caacacccat acctgaaaag aataaatgtg tgactttcaa atcccctttc     4020

gcagtgaaag aaacagcaaa cacttaagat tcagcatctg ttctccagtt gcactgagga     4080

atgcactgtc tcgcagcacc agctctgcag agcccttgcc ccagactctt tgcggtttta     4140

tttatatgta tttccatatt tcattcctgt gtgtcactgc tgcattggtg tggcagcaag     4200

tgaccaaatg ctacaggtct tactatggac accaggtcag gtgcaaccac acaaaacaaa     4260

gccagttcca tgagctgcct atgatatgca ttgcggaagt aacattttac ccagggtgtg     4320

ccattgcagt gatataaata tatttttttc ttagactaaa tatgagctga ctatctcttt     4380

tgatgtgtgt acataggtgt gagtgtgtgt gtatgcgtgc ctgtctgtgt gcgggtgtgt     4440

gtatgtgcat agcctcatgc ttaggactac ccatgaatgt tgtggaatgc tacacctgga     4500

gagttctggt tttccaccag tttcaagatg aagaactaca tgatacagtg gacctggaga     4560

ccatcccctt ggaaagacaa cccagagatg ttcagcatcc tgtatctaca cgcatcctgt     4620

atctacacgt gtattttgta gctgtcacac taaccttaat aagaattcta cagctttgga     4680

cagaggcatt ttcaccttaa tggtgaagta atttaaaata taaatccatt caggtgacaa     4740

cccatcatca aaattacaaa ttttctgatt gaactcatct gaatcatcag ttccttgatg     4800

gagagagaga aggagatgga atgtgtctgg taaccccaaa tggagtacaa gtagcctttg     4860

ttttcctgca taaatggact tgttgaatgc gaacgaatat atgcaattca tatacttttg     4920

gagatgaacg tagatatgtg tgtcagcttt gagatggtgt gtcctggatt aatactttgt     4980

ctcccaatat cacagaaaaa tacatgccag tgactcttga ggttaaggta gttgggatga     5040

aatggcctca ggcaatttca cattccctaa ttacctggaa agttctacag taattaatat     5100

gcagctaact cctgttgccc tcacaagagc atcagccttc tagaatcgga gctccggagt     5160

gtgaagattc agtattgata tgatatgtat accaaactcc agccaactta ctgccatttt     5220

tcataatctg agtggctgcc ttgcttatcc taagctgtgg ttgcagaaac cgtggccatt     5280

tatataagct ataacatcaa atcagggaaa aatgaggaaa aaaaatagat tctgaaccat     5340

ttattgttga ataagtagag aaaatcatca ataaatattt attacattct gacagggtgt     5400

gtggcattgt gttctatgcc agagtgacaa agttgattca cccctttttg gggaccttaa     5460

tatatttttt aagggatgtg cctatgcatt gatgcctgaa aaatatgtat aaagaaatga     5520

ggttgactct tctgagcagt tcatcttttc cagaggtaag ggtaggaggc caacttcagg     5580

gtctgggtct gagcccgtgg gcaagccctg gccgagtgag ctccaatgct aactcatgtg     5640

ccgatctcta gagcagtggg aaactacccc gctgcaccaa atcaagtagc ttcaccttgt     5700

gtatgcaggc cccaagttat tttttagcaa tcttacgagt gaaatgttct ggtgggttga     5760

aaaacgttct tattttaaag aaaggttgtg ctcgctacac tgctggtgtg tgcattctga     5820

gacctcttgt attcaatctg tgaaggatat gtgtattaat ccgtacaccc gtatagcctc     5880

aatatttgtc tgaagacact taaattctga cccataaagg aaagttctag aagcaatatt     5940

ttcacttatt taacattctc caaacaacat caagcattga tacacactga agagtgcgtt     6000

tattttttgt atcactctaa gtatgttgga atatgcaagg actgtggttc aaattagaat     6060

gtataaggca tattataatt tagttcatac tgaataagaa attaacagaa cattgttcgg     6120

ttcacacgtt ccaaactttg agtgatttct ggagttagac atagattttc tattttgttt     6180

taatttgtca aggtattttt cttcccttca tgaactttag gtacacataa cttatgtcat     6240

ttatttatgg tcttttatac ctagtttgta aaattgtaaa atagcaaact aaatgcaaag     6300

agtttgcatt tgaaaataat aaagtagttg ccgtatacaa ccctgcaaaa aaaaaaaaaa     6360

aaaa                                                                  6364


<210>  19
<211>  1892
<212>  DNA
<213>  Homo sapiens

<400>  19
gaggctcagg aaaaagatga actggtccca ttcctgcatc tccttttgct ggatctactt       60

tgctgcttcc agactgagag ctgcagagac ggcagatgga aaatatgctc agaagttgtt      120

taatgacctt tttgaagatt attctaatgc tcttcgtcca gtggaagata cagataaagt      180

cctgaatgtg accctgcaga ttacgctctc tcagattaag gatatggatg aaagaaacca      240

aattctgact gcttatttgt ggatccgcca aatctggcac gatgcctatc tcacgtggga      300

ccgagatcag tacgatggcc tagactccat caggatcccc agtgacctcg tgtggaggcc      360

agacatcgtc ttatataaca aggctgatga tgaatcttca gagcctgtga acaccaatgt      420

ggtcctgcgg tatgatgggc tgatcacctg ggatgcaccg gccatcacca aaagctcctg      480

tgtggtggat gtcacctact tcccttttga caaccagcag tgcaacctga cttttggttc      540

ctggacctac aatggcaatc aggtggacat attcaacgcc ttggacagcg gagatctctc      600

tgacttcatt gaagatgtgg aatgggaggt ccatggcatg cccgctgtga agaatgtgat      660

ctcctatggc tgctgctctg agccttaccc ggatgtcaca ttcaccctcc ttctgaagag      720

gaggtcctcg ttctatatcg tcaacctcct catcccatgc gtcctcatat cttttctggc      780

tcctctgagt ttttatctcc cagcagcctc cggagaaaag gtctccctgg gagtgaccat      840

cctgttggcc atgactgtat ttcagctaat ggtggcagaa atcatgccgg cctcagaaaa      900

tgtgcccctg ataggtaaat actacatagc cacgatggcc ctgatcacag cctccactgc      960

gttgaccatc atggtgatga atatccactt ctgtggggcc gaggcccggc cggtgccaca     1020

ctgggccagg gtggtcatcc tgaaatacat gtccagggtc ttgtttgtct atgatgtggg     1080

tgaaagctgc ctcagcccgc accacagtag agagcgggac cacctcacga aagtttatag     1140

caaactccca gagtctaacc tgaaagcagc caggaacaaa gacctttcca gaaagaagga     1200

catgaacaaa cgcttaaaga acgacctggg ctgccagggt aagaaccctc aggaggccga     1260

gagttactgt gcacagtaca aagtgctgac gaggaatatt gagtacatcg ccaagtgcct     1320

caaagaccac aaggccacca attccaaggg gagtgaatgg aagaaggtgg cgaaagtcat     1380

agaccgattc ttcatgtgga tttttttcat tatggtgttt gtgatgacta ttttgatcat     1440

agcaagagcg gattagtcac agatattggc tttgctatct gggtagaaat taatacaatt     1500

ccctgtgatc tattccaatg ttcttccaag atttttgttc atctataatt taggggttat     1560

gttgtctgtg ctttttattt ttagcttcaa atgaatgtcg aagctatctg ctctgttaaa     1620

ttaagcagaa gatccaaaat ttcaagggta ggaagatgga agaaataggg aaagagccct     1680

tttatagccc accgtagtgg tgggtgactg gcctctagtt tatataatta tttacctctt     1740

tggcagtaca gataacaaaa tacactttac tggtaaaatt taaaacaaaa aaggcaaaac     1800

aaaacaaact cattttcccc ttagttccca ttaaaatatg catttgaaaa atgaaatagt     1860

catatatata ttagtgtgat ttaagtctca at                                   1892


<210>  20
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asn Ile Thr Asn Cys Thr Thr Glu Ala Ser Met Ala Ile Arg Pro 
1               5                   10                  15      


Lys Thr Ile Thr Glu Lys Met Leu Ile Cys Met Thr Leu Val Val Ile 
            20                  25                  30          


Thr Thr Leu Thr Thr Leu Leu Asn Leu Ala Val Ile Met Ala Ile Gly 
        35                  40                  45              


Thr Thr Lys Lys Leu His Gln Pro Ala Asn Tyr Leu Ile Cys Ser Leu 
    50                  55                  60                  


Ala Val Thr Asp Leu Leu Val Ala Val Leu Val Met Pro Leu Ser Ile 
65                  70                  75                  80  


Ile Tyr Ile Val Met Asp Arg Trp Lys Leu Gly Tyr Phe Leu Cys Glu 
                85                  90                  95      


Val Trp Leu Ser Val Asp Met Thr Cys Cys Thr Cys Ser Ile Leu His 
            100                 105                 110         


Leu Cys Val Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asn Ala Ile 
        115                 120                 125             


Glu Tyr Ala Arg Lys Arg Thr Ala Lys Arg Ala Ala Leu Met Ile Leu 
    130                 135                 140                 


Thr Val Trp Thr Ile Ser Ile Phe Ile Ser Met Pro Pro Leu Phe Trp 
145                 150                 155                 160 


Arg Ser His Arg Arg Leu Ser Pro Pro Pro Ser Gln Cys Thr Ile Gln 
                165                 170                 175     


His Asp His Val Ile Tyr Thr Ile Tyr Ser Thr Leu Gly Ala Phe Tyr 
            180                 185                 190         


Ile Pro Leu Thr Leu Ile Leu Ile Leu Tyr Tyr Arg Ile Tyr His Ala 
        195                 200                 205             


Ala Lys Ser Leu Tyr Gln Lys Arg Gly Ser Ser Arg His Leu Ser Asn 
    210                 215                 220                 


Arg Ser Thr Asp Ser Gln Asn Ser Phe Ala Ser Cys Lys Leu Thr Gln 
225                 230                 235                 240 


Thr Phe Cys Val Ser Asp Phe Ser Thr Ser Asp Pro Thr Thr Glu Phe 
                245                 250                 255     


Glu Lys Phe His Ala Ser Ile Arg Ile Pro Pro Phe Asp Asn Asp Leu 
            260                 265                 270         


Asp His Pro Gly Glu Arg Gln Gln Ile Ser Ser Thr Arg Glu Arg Lys 
        275                 280                 285             


Ala Ala Arg Ile Leu Gly Leu Ile Leu Gly Ala Phe Ile Leu Ser Trp 
    290                 295                 300                 


Leu Pro Phe Phe Ile Lys Glu Leu Ile Val Gly Leu Ser Ile Tyr Thr 
305                 310                 315                 320 


Val Ser Ser Glu Val Ala Asp Phe Leu Thr Trp Leu Gly Tyr Val Asn 
                325                 330                 335     


Ser Leu Ile Asn Pro Leu Leu Tyr Thr Ser Phe Asn Glu Asp Phe Lys 
            340                 345                 350         


Leu Ala Phe Lys Lys Leu Ile Arg Cys Arg Glu His Thr 
        355                 360                 365 


<210>  21
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Ala Ala Ala Thr Ala Ala Glu Gly Val Pro Ser Arg Gly Pro 
1               5                   10                  15      


Pro Gly Glu Val Ile His Leu Asn Val Gly Gly Lys Arg Phe Ser Thr 
            20                  25                  30          


Ser Arg Gln Thr Leu Thr Trp Ile Pro Asp Ser Phe Phe Ser Ser Leu 
        35                  40                  45              


Leu Ser Gly Arg Ile Ser Thr Leu Lys Asp Glu Thr Gly Ala Ile Phe 
    50                  55                  60                  


Ile Asp Arg Asp Pro Thr Val Phe Ala Pro Ile Leu Asn Phe Leu Arg 
65                  70                  75                  80  


Thr Lys Glu Leu Asp Pro Arg Gly Val His Gly Ser Ser Leu Leu His 
                85                  90                  95      


Glu Ala Gln Phe Tyr Gly Leu Thr Pro Leu Val Arg Arg Leu Gln Leu 
            100                 105                 110         


Arg Glu Glu Leu Asp Arg Ser Ser Cys Gly Asn Val Leu Phe Asn Gly 
        115                 120                 125             


Tyr Leu Pro Pro Pro Val Phe Pro Val Lys Arg Arg Asn Arg His Ser 
    130                 135                 140                 


Leu Val Gly Pro Gln Gln Leu Gly Gly Arg Pro Ala Pro Val Arg Arg 
145                 150                 155                 160 


Ser Asn Thr Met Pro Pro Asn Leu Gly Asn Ala Gly Leu Leu Gly Arg 
                165                 170                 175     


Met Leu Asp Glu Lys Thr Pro Pro Ser Pro Ser Gly Gln Pro Glu Glu 
            180                 185                 190         


Pro Gly Met Val Arg Leu Val Cys Gly His His Asn Trp Ile Ala Val 
        195                 200                 205             


Ala Tyr Thr Gln Phe Leu Val Cys Tyr Arg Leu Lys Glu Ala Ser Gly 
    210                 215                 220                 


Trp Gln Leu Val Phe Ser Ser Pro Arg Leu Asp Trp Pro Ile Glu Arg 
225                 230                 235                 240 


Leu Ala Leu Thr Ala Arg Val His Gly Gly Ala Leu Gly Glu His Asp 
                245                 250                 255     


Lys Met Val Ala Ala Ala Thr Gly Ser Glu Ile Leu Leu Trp Ala Leu 
            260                 265                 270         


Gln Ala Glu Gly Gly Gly Ser Glu Ile Gly Val Phe His Leu Gly Val 
        275                 280                 285             


Pro Val Glu Ala Leu Phe Phe Val Gly Asn Gln Leu Ile Ala Thr Ser 
    290                 295                 300                 


His Thr Gly Arg Ile Gly Val Trp Asn Ala Val Thr Lys His Trp Gln 
305                 310                 315                 320 


Val Gln Glu Val Gln Pro Ile Thr Ser Tyr Asp Ala Ala Gly Ser Phe 
                325                 330                 335     


Leu Leu Leu Gly Cys Asn Asn Gly Ser Ile Tyr Tyr Val Asp Val Gln 
            340                 345                 350         


Lys Phe Pro Leu Arg Met Lys Asp Asn Asp Leu Leu Val Ser Glu Leu 
        355                 360                 365             


Tyr Arg Asp Pro Ala Glu Asp Gly Val Thr Ala Leu Ser Val Tyr Leu 
    370                 375                 380                 


Thr Pro Lys Thr Ser Asp Ser Gly Asn Trp Ile Glu Ile Ala Tyr Gly 
385                 390                 395                 400 


Thr Ser Ser Gly Gly Val Arg Val Ile Val Gln His Pro Glu Thr Val 
                405                 410                 415     


Gly Ser Gly Pro Gln Leu Phe Gln Thr Phe Thr Val His Arg Ser Pro 
            420                 425                 430         


Val Thr Lys Ile Met Leu Ser Glu Lys His Leu Ile Ser Val Cys Ala 
        435                 440                 445             


Asp Asn Asn His Val Arg Thr Trp Ser Val Thr Arg Phe Arg Gly Met 
    450                 455                 460                 


Ile Ser Thr Gln Pro Gly Ser Thr Pro Leu Ala Ser Phe Lys Ile Leu 
465                 470                 475                 480 


Ala Leu Glu Ser Ala Asp Gly His Gly Gly Cys Ser Ala Gly Asn Asp 
                485                 490                 495     


Ile Gly Pro Tyr Gly Glu Arg Asp Asp Gln Leu Val Phe Ile Gln Lys 
            500                 505                 510         


Val Val Pro Ser Ala Ser Gln Leu Phe Val Arg Leu Ser Ser Thr Gly 
        515                 520                 525             


Gln Arg Val Cys Ser Val Arg Ser Val Asp Gly Ser Pro Thr Thr Ala 
    530                 535                 540                 


Phe Thr Val Leu Glu Cys Glu Gly Ser Arg Arg Leu Gly Ser Arg Pro 
545                 550                 555                 560 


Arg Arg Tyr Leu Leu Thr Gly Gln Ala Asn Gly Ser Leu Ala Met Trp 
                565                 570                 575     


Asp Leu Thr Thr Ala Met Asp Gly Leu Gly Gln Ala Pro Ala Gly Gly 
            580                 585                 590         


Leu Thr Glu Gln Glu Leu Met Glu Gln Leu Glu His Cys Glu Leu Ala 
        595                 600                 605             


Pro Pro Ala Pro Ser Ala Pro Ser Trp Gly Cys Leu Pro Ser Pro Ser 
    610                 615                 620                 


Pro Arg Ile Ser Leu Thr Ser Leu His Ser Ala Ser Ser Asn Thr Ser 
625                 630                 635                 640 


Leu Ser Gly His Arg Gly Ser Pro Ser Pro Pro Gln Ala Glu Ala Arg 
                645                 650                 655     


Arg Arg Gly Gly Gly Ser Phe Val Glu Arg Cys Gln Glu Leu Val Arg 
            660                 665                 670         


Ser Gly Pro Asp Leu Arg Arg Pro Pro Thr Pro Ala Pro Trp Pro Ser 
        675                 680                 685             


Ser Gly Leu Gly Thr Pro Leu Thr Pro Pro Lys Met Lys Leu Asn Glu 
    690                 695                 700                 


Thr Ser Phe 
705         


<210>  22
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Lys His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu 
            660                 665                 670         


Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val 
        675                 680                 685             


Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala 
    690                 695                 700                 


Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
705                 710                 715                 


<210>  23
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  24
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg Gly Ser Leu Lys 
1               5                   10                  15      


Val Ser Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn Phe Ser Thr Gln 
            20                  25                  30          


Lys Val Lys Met His Ile His Ser Thr Asn Glu Val Thr Arg Ile Tyr 
        35                  40                  45              


Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro Asp Arg Tyr Val 
    50                  55                  60                  


Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly Gly Ile Asp Pro 
65                  70                  75                  80  


Gln Ser Gly Ala Ala Val Val His Glu Thr Val Arg Ser Phe Gly Thr 
                85                  90                  95      


Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile Leu Phe Ala Ser 
            100                 105                 110         


Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu 
        115                 120                 125             


Asp Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala Tyr Ile Asn Ala 
    130                 135                 140                 


Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro 
145                 150                 155                 160 


Leu Met Tyr Ser Leu Val Tyr Asn Leu Thr Lys Glu Leu Lys Ser Pro 
                165                 170                 175     


Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser Trp Thr Lys Lys 
            180                 185                 190         


Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile Ser Lys Leu Gly 
        195                 200                 205             


Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu Gly Ile Ala Ser 
    210                 215                 220                 


Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn Lys Phe Ser Gly 
225                 230                 235                 240 


Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu Leu Val Glu Lys 
                245                 250                 255     


Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val Ala Gln Val Arg 
            260                 265                 270         


Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val Leu Pro Phe Asp 
        275                 280                 285             


Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala Asp Lys Ile Tyr 
    290                 295                 300                 


Asn Ile Ser Met Lys His Pro Gln Glu Met Lys Thr Tyr Ser Leu Ser 
305                 310                 315                 320 


Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr Glu Ile Ala Ser 
                325                 330                 335     


Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser Asn Pro Ile Leu 
            340                 345                 350         


Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu Arg Ala Phe Ile 
        355                 360                 365             


Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg His Val Ile Tyr 
    370                 375                 380                 


Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile 
385                 390                 395                 400 


Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp Pro Ser Lys Ala 
                405                 410                 415     


Trp Gly Asp Val Lys Arg Gln Ile Ser Val Ala Ala Phe Thr Val Gln 
            420                 425                 430         


Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
        435                 440         


<210>  25
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Trp Arg Gly Ala Gly Pro Ser Val Pro Gly Ala Pro Gly Gly 
1               5                   10                  15      


Val Gly Leu Ser Leu Gly Leu Leu Leu Gln Leu Leu Leu Leu Leu Gly 
            20                  25                  30          


Pro Ala Arg Gly Phe Gly Asp Glu Glu Glu Arg Arg Cys Asp Pro Ile 
        35                  40                  45              


Arg Ile Ser Met Cys Gln Asn Leu Gly Tyr Asn Val Thr Lys Met Pro 
    50                  55                  60                  


Asn Leu Val Gly His Glu Leu Gln Thr Asp Ala Glu Leu Gln Leu Thr 
65                  70                  75                  80  


Thr Phe Thr Pro Leu Ile Gln Tyr Gly Cys Ser Ser Gln Leu Gln Phe 
                85                  90                  95      


Phe Leu Cys Ser Val Tyr Val Pro Met Cys Thr Glu Lys Ile Asn Ile 
            100                 105                 110         


Pro Ile Gly Pro Cys Gly Gly Met Cys Leu Ser Val Lys Arg Arg Cys 
        115                 120                 125             


Glu Pro Val Leu Lys Glu Phe Gly Phe Ala Trp Pro Glu Ser Leu Asn 
    130                 135                 140                 


Cys Ser Lys Phe Pro Pro Gln Asn Asp His Asn His Met Cys Met Glu 
145                 150                 155                 160 


Gly Pro Gly Asp Glu Glu Val Pro Leu Pro His Lys Thr Pro Ile Gln 
                165                 170                 175     


Pro Gly Glu Glu Cys His Ser Val Gly Thr Asn Ser Asp Gln Tyr Ile 
            180                 185                 190         


Trp Val Lys Arg Ser Leu Asn Cys Val Leu Lys Cys Gly Tyr Asp Ala 
        195                 200                 205             


Gly Leu Tyr Ser Arg Ser Ala Lys Glu Phe Thr Asp Ile Trp Met Ala 
    210                 215                 220                 


Val Trp Ala Ser Leu Cys Phe Ile Ser Thr Ala Phe Thr Val Leu Thr 
225                 230                 235                 240 


Phe Leu Ile Asp Ser Ser Arg Phe Ser Tyr Pro Glu Arg Pro Ile Ile 
                245                 250                 255     


Phe Leu Ser Met Cys Tyr Asn Ile Tyr Ser Ile Ala Tyr Ile Val Arg 
            260                 265                 270         


Leu Thr Val Gly Arg Glu Arg Ile Ser Cys Asp Phe Glu Glu Ala Ala 
        275                 280                 285             


Glu Pro Val Leu Ile Gln Glu Gly Leu Lys Asn Thr Gly Cys Ala Ile 
    290                 295                 300                 


Ile Phe Leu Leu Met Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp 
305                 310                 315                 320 


Val Ile Leu Thr Leu Thr Trp Phe Leu Ala Ala Gly Leu Lys Trp Gly 
                325                 330                 335     


His Glu Ala Ile Glu Met His Ser Ser Tyr Phe His Ile Ala Ala Trp 
            340                 345                 350         


Ala Ile Pro Ala Val Lys Thr Ile Val Ile Leu Ile Met Arg Leu Val 
        355                 360                 365             


Asp Ala Asp Glu Leu Thr Gly Leu Cys Tyr Val Gly Asn Gln Asn Leu 
    370                 375                 380                 


Asp Ala Leu Thr Gly Phe Val Val Ala Pro Leu Phe Thr Tyr Leu Val 
385                 390                 395                 400 


Ile Gly Thr Leu Phe Ile Ala Ala Gly Leu Val Ala Leu Phe Lys Ile 
                405                 410                 415     


Arg Ser Asn Leu Gln Lys Asp Gly Thr Lys Thr Asp Lys Leu Glu Arg 
            420                 425                 430         


Leu Met Val Lys Ile Gly Val Phe Ser Val Leu Tyr Thr Val Pro Ala 
        435                 440                 445             


Thr Cys Val Ile Ala Cys Tyr Phe Tyr Glu Ile Ser Asn Trp Ala Leu 
    450                 455                 460                 


Phe Arg Tyr Ser Ala Asp Asp Ser Asn Met Ala Val Glu Met Leu Lys 
465                 470                 475                 480 


Ile Phe Met Ser Leu Leu Val Gly Ile Thr Ser Gly Met Trp Ile Trp 
                485                 490                 495     


Ser Ala Lys Thr Leu His Thr Trp Gln Lys Cys Ser Asn Arg Leu Val 
            500                 505                 510         


Asn Ser Gly Lys Val Lys Arg Glu Lys Arg Gly Asn Gly Trp Val Lys 
        515                 520                 525             


Pro Gly Lys Gly Ser Glu Thr Val Val 
    530                 535         


<210>  26
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ser Lys Pro Pro Ala Pro Asn Pro Thr Pro Pro Arg Asn Leu Asp 
1               5                   10                  15      


Ser Arg Thr Phe Ile Thr Ile Gly Asp Arg Asn Phe Glu Val Glu Ala 
            20                  25                  30          


Asp Asp Leu Val Thr Ile Ser Glu Leu Gly Arg Gly Ala Tyr Gly Val 
        35                  40                  45              


Val Glu Lys Val Arg His Ala Gln Ser Gly Thr Ile Met Ala Val Lys 
    50                  55                  60                  


Arg Ile Arg Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu Leu Met 
65                  70                  75                  80  


Asp Leu Asp Ile Asn Met Arg Thr Val Asp Cys Phe Tyr Thr Val Thr 
                85                  90                  95      


Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys Met Glu 
            100                 105                 110         


Leu Met Asp Thr Ser Leu Asp Lys Phe Tyr Arg Lys Val Leu Asp Lys 
        115                 120                 125             


Asn Met Thr Ile Pro Glu Asp Ile Leu Gly Glu Ile Ala Val Ser Ile 
    130                 135                 140                 


Val Arg Ala Leu Glu His Leu His Ser Lys Leu Ser Val Ile His Arg 
145                 150                 155                 160 


Asp Val Lys Pro Ser Asn Val Leu Ile Asn Lys Glu Gly His Val Lys 
                165                 170                 175     


Met Cys Asp Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val Ala Lys 
            180                 185                 190         


Thr Met Asp Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg Ile Asn 
        195                 200                 205             


Pro Glu Leu Asn Gln Lys Gly Tyr Asn Val Lys Ser Asp Val Trp Ser 
    210                 215                 220                 


Leu Gly Ile Thr Met Ile Glu Met Ala Ile Leu Arg Phe Pro Tyr Glu 
225                 230                 235                 240 


Ser Trp Gly Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu Glu Pro 
                245                 250                 255     


Ser Pro Gln Leu Pro Ala Asp Arg Phe Ser Pro Glu Phe Val Asp Phe 
            260                 265                 270         


Thr Ala Gln Cys Leu Arg Lys Asn Pro Ala Glu Arg Met Ser Tyr Leu 
        275                 280                 285             


Glu Leu Met Glu His Pro Phe Phe Thr Leu His Lys Thr Lys Lys Thr 
    290                 295                 300                 


Asp Ile Ala Ala Phe Val Lys Glu Ile Leu Gly Glu Asp Ser 
305                 310                 315             


<210>  27
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Glu Ser Pro Ala Ser Ser Gln Pro Ala Ser Met Pro Gln Ser Lys 
1               5                   10                  15      


Gly Lys Ser Lys Arg Lys Lys Asp Leu Arg Ile Ser Cys Met Ser Lys 
            20                  25                  30          


Pro Pro Ala Pro Asn Pro Thr Pro Pro Arg Asn Leu Asp Ser Arg Thr 
        35                  40                  45              


Phe Ile Thr Ile Gly Asp Arg Asn Phe Glu Val Glu Ala Asp Asp Leu 
    50                  55                  60                  


Val Thr Ile Ser Glu Leu Gly Arg Gly Ala Tyr Gly Val Val Glu Lys 
65                  70                  75                  80  


Val Arg His Ala Gln Ser Gly Thr Ile Met Ala Val Lys Arg Ile Arg 
                85                  90                  95      


Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu Leu Met Asp Leu Asp 
            100                 105                 110         


Ile Asn Met Arg Thr Val Asp Cys Phe Tyr Thr Val Thr Phe Tyr Gly 
        115                 120                 125             


Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys Met Glu Leu Met Asp 
    130                 135                 140                 


Thr Ser Leu Asp Lys Phe Tyr Arg Lys Val Leu Asp Lys Asn Met Thr 
145                 150                 155                 160 


Ile Pro Glu Asp Ile Leu Gly Glu Ile Ala Val Ser Ile Val Arg Ala 
                165                 170                 175     


Leu Glu His Leu His Ser Lys Leu Ser Val Ile His Arg Asp Val Lys 
            180                 185                 190         


Pro Ser Asn Val Leu Ile Asn Lys Glu Gly His Val Lys Met Cys Asp 
        195                 200                 205             


Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val Ala Lys Thr Met Asp 
    210                 215                 220                 


Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg Ile Asn Pro Glu Leu 
225                 230                 235                 240 


Asn Gln Lys Gly Tyr Asn Val Lys Ser Asp Val Trp Ser Leu Gly Ile 
                245                 250                 255     


Thr Met Ile Glu Met Ala Ile Leu Arg Phe Pro Tyr Glu Ser Trp Gly 
            260                 265                 270         


Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu Glu Pro Ser Pro Gln 
        275                 280                 285             


Leu Pro Ala Asp Arg Phe Ser Pro Glu Phe Val Asp Phe Thr Ala Gln 
    290                 295                 300                 


Cys Leu Arg Lys Asn Pro Ala Glu Arg Met Ser Tyr Leu Glu Leu Met 
305                 310                 315                 320 


Glu His Pro Phe Phe Thr Leu His Lys Thr Lys Lys Thr Asp Ile Ala 
                325                 330                 335     


Ala Phe Val Lys Glu Ile Leu Gly Glu Asp Ser 
            340                 345         


<210>  28
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Val Pro His Leu Leu Leu Leu Cys Leu Leu Pro Leu Val Arg Ala 
1               5                   10                  15      


Thr Glu Pro His Glu Gly Arg Ala Asp Glu Gln Ser Ala Glu Ala Ala 
            20                  25                  30          


Leu Ala Val Pro Asn Ala Ser His Phe Phe Ser Trp Asn Asn Tyr Thr 
        35                  40                  45              


Phe Ser Asp Trp Gln Asn Phe Val Gly Arg Arg Arg Tyr Gly Ala Glu 
    50                  55                  60                  


Ser Gln Asn Pro Thr Val Lys Ala Leu Leu Ile Val Ala Tyr Ser Phe 
65                  70                  75                  80  


Ile Ile Val Phe Ser Leu Phe Gly Asn Val Leu Val Cys His Val Ile 
                85                  90                  95      


Phe Lys Asn Gln Arg Met His Ser Ala Thr Ser Leu Phe Ile Val Asn 
            100                 105                 110         


Leu Ala Val Ala Asp Ile Met Ile Thr Leu Leu Asn Thr Pro Phe Thr 
        115                 120                 125             


Leu Val Arg Phe Val Asn Ser Thr Trp Ile Phe Gly Lys Gly Met Cys 
    130                 135                 140                 


His Val Ser Arg Phe Ala Gln Tyr Cys Ser Leu His Val Ser Ala Leu 
145                 150                 155                 160 


Thr Leu Thr Ala Ile Ala Val Asp Arg His Gln Val Ile Met His Pro 
                165                 170                 175     


Leu Lys Pro Arg Ile Ser Ile Thr Lys Gly Val Ile Tyr Ile Ala Val 
            180                 185                 190         


Ile Trp Thr Met Ala Thr Phe Phe Ser Leu Pro His Ala Ile Cys Gln 
        195                 200                 205             


Lys Leu Phe Thr Phe Lys Tyr Ser Glu Asp Ile Val Arg Ser Leu Cys 
    210                 215                 220                 


Leu Pro Asp Phe Pro Glu Pro Ala Asp Leu Phe Trp Lys Tyr Leu Asp 
225                 230                 235                 240 


Leu Ala Thr Phe Ile Leu Leu Tyr Ile Leu Pro Leu Leu Ile Ile Ser 
                245                 250                 255     


Val Ala Tyr Ala Arg Val Ala Lys Lys Leu Trp Leu Cys Asn Met Ile 
            260                 265                 270         


Gly Asp Val Thr Thr Glu Gln Tyr Phe Ala Leu Arg Arg Lys Lys Lys 
        275                 280                 285             


Lys Thr Ile Lys Met Leu Met Leu Val Val Val Leu Phe Ala Leu Cys 
    290                 295                 300                 


Trp Phe Pro Leu Asn Cys Tyr Val Leu Leu Leu Ser Ser Lys Val Ile 
305                 310                 315                 320 


Arg Thr Asn Asn Ala Leu Tyr Phe Ala Phe His Trp Phe Ala Met Ser 
                325                 330                 335     


Ser Thr Cys Tyr Asn Pro Phe Ile Tyr Cys Trp Leu Asn Glu Asn Phe 
            340                 345                 350         


Arg Ile Glu Leu Lys Ala Leu Leu Ser Met Cys Gln Arg Pro Pro Lys 
        355                 360                 365             


Pro Gln Glu Asp Arg Gln Pro Ser Pro Val Pro Ser Phe Arg Val Ala 
    370                 375                 380                 


Trp Thr Glu Lys Asn Asp Gly Gln Arg Ala Pro Leu Ala Asn Asn Leu 
385                 390                 395                 400 


Leu Pro Thr Ser Gln Leu Gln Ser Gly Lys Thr Asp Leu Ser Ser Val 
                405                 410                 415     


Glu Pro Ile Val Thr Met Ser 
            420             


<210>  29
<211>  545
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Glu Pro Ser Gly Ser Pro Val His Val Gln Leu Pro Gln Gln 
1               5                   10                  15      


Ala Ala Pro Val Thr Ala Ala Ala Ala Ala Ala Pro Ala Ala Ala Thr 
            20                  25                  30          


Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Ala Gln Ala Val Gly Trp Pro Ile Cys Arg Asp Ala Tyr Glu 
    50                  55                  60                  


Leu Gln Glu Val Ile Gly Ser Gly Ala Thr Ala Val Val Gln Ala Ala 
65                  70                  75                  80  


Leu Cys Lys Pro Arg Gln Glu Arg Val Ala Ile Lys Arg Ile Asn Leu 
                85                  90                  95      


Glu Lys Cys Gln Thr Ser Met Asp Glu Leu Leu Lys Glu Ile Gln Ala 
            100                 105                 110         


Met Ser Gln Cys Ser His Pro Asn Val Val Thr Tyr Tyr Thr Ser Phe 
        115                 120                 125             


Val Val Lys Asp Glu Leu Trp Leu Val Met Lys Leu Leu Ser Gly Gly 
    130                 135                 140                 


Ser Met Leu Asp Ile Ile Lys Tyr Ile Val Asn Arg Gly Glu His Lys 
145                 150                 155                 160 


Asn Gly Val Leu Glu Glu Ala Ile Ile Ala Thr Ile Leu Lys Glu Val 
                165                 170                 175     


Leu Glu Gly Leu Asp Tyr Leu His Arg Asn Gly Gln Ile His Arg Asp 
            180                 185                 190         


Leu Lys Ala Gly Asn Ile Leu Leu Gly Glu Asp Gly Ser Val Gln Ile 
        195                 200                 205             


Ala Asp Phe Gly Val Ser Ala Phe Leu Ala Thr Gly Gly Asp Val Thr 
    210                 215                 220                 


Arg Asn Lys Val Arg Lys Thr Phe Val Gly Thr Pro Cys Trp Met Ala 
225                 230                 235                 240 


Pro Glu Val Met Glu Gln Val Arg Gly Tyr Asp Phe Lys Ala Asp Met 
                245                 250                 255     


Trp Ser Phe Gly Ile Thr Ala Ile Glu Leu Ala Thr Gly Ala Ala Pro 
            260                 265                 270         


Tyr His Lys Tyr Pro Pro Met Lys Val Leu Met Leu Thr Leu Gln Asn 
        275                 280                 285             


Asp Pro Pro Thr Leu Glu Thr Gly Val Glu Asp Lys Glu Met Met Lys 
    290                 295                 300                 


Lys Tyr Gly Lys Ser Phe Arg Lys Leu Leu Ser Leu Cys Leu Gln Lys 
305                 310                 315                 320 


Asp Pro Ser Lys Arg Pro Thr Ala Ala Glu Leu Leu Lys Cys Lys Phe 
                325                 330                 335     


Phe Gln Lys Ala Lys Asn Arg Glu Tyr Leu Ile Glu Lys Leu Leu Thr 
            340                 345                 350         


Arg Thr Pro Asp Ile Ala Gln Arg Ala Lys Lys Val Arg Arg Val Pro 
        355                 360                 365             


Gly Ser Ser Gly His Leu His Lys Thr Glu Asp Gly Asp Trp Glu Trp 
    370                 375                 380                 


Ser Asp Asp Glu Met Asp Glu Lys Ser Glu Glu Gly Lys Ala Ala Phe 
385                 390                 395                 400 


Ser Gln Glu Lys Ser Arg Arg Val Lys Glu Glu Asn Pro Glu Ile Ala 
                405                 410                 415     


Val Ser Ala Ser Thr Ile Pro Glu Gln Ile Gln Ser Leu Ser Val His 
            420                 425                 430         


Asp Ser Gln Gly Pro Pro Asn Ala Asn Glu Asp Tyr Arg Glu Ala Ser 
        435                 440                 445             


Ser Cys Ala Val Asn Leu Val Leu Arg Leu Arg Asn Ser Arg Lys Glu 
    450                 455                 460                 


Leu Asn Asp Ile Arg Phe Glu Phe Thr Pro Gly Arg Asp Thr Ala Asp 
465                 470                 475                 480 


Gly Val Ser Gln Glu Leu Phe Ser Ala Gly Leu Val Asp Gly His Asp 
                485                 490                 495     


Val Val Ile Val Ala Ala Asn Leu Gln Lys Ile Val Asp Asp Pro Lys 
            500                 505                 510         


Ala Leu Lys Thr Leu Thr Phe Lys Leu Ala Ser Gly Cys Asp Gly Ser 
        515                 520                 525             


Glu Ile Pro Asp Glu Val Lys Leu Ile Gly Phe Ala Gln Leu Ser Val 
    530                 535                 540                 


Ser 
545 


<210>  30
<211>  1036
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Glu Val Val Gly Asp Phe Glu Tyr Ser Lys Arg Asp Leu Val Gly 
1               5                   10                  15      


His Gly Ala Phe Ala Val Val Phe Arg Gly Arg His Arg Gln Lys Thr 
            20                  25                  30          


Asp Trp Glu Val Ala Ile Lys Ser Ile Asn Lys Lys Asn Leu Ser Lys 
        35                  40                  45              


Ser Gln Ile Leu Leu Gly Lys Glu Ile Lys Ile Leu Lys Glu Leu Gln 
    50                  55                  60                  


His Glu Asn Ile Val Ala Leu Tyr Asp Val Gln Glu Leu Pro Asn Ser 
65                  70                  75                  80  


Val Phe Leu Val Met Glu Tyr Cys Asn Gly Gly Asp Leu Ala Asp Tyr 
                85                  90                  95      


Leu Gln Ala Lys Gly Thr Leu Ser Glu Asp Thr Ile Arg Val Phe Leu 
            100                 105                 110         


His Gln Ile Ala Ala Ala Met Arg Ile Leu His Ser Lys Gly Ile Ile 
        115                 120                 125             


His Arg Asp Leu Lys Pro Gln Asn Ile Leu Leu Ser Tyr Ala Asn Arg 
    130                 135                 140                 


Arg Lys Ser Ser Val Ser Gly Ile Arg Ile Lys Ile Ala Asp Phe Gly 
145                 150                 155                 160 


Phe Ala Arg Tyr Leu His Ser Asn Met Met Ala Ala Thr Leu Cys Gly 
                165                 170                 175     


Ser Pro Met Tyr Met Ala Pro Glu Val Ile Met Ser Gln His Tyr Asp 
            180                 185                 190         


Ala Lys Ala Asp Leu Trp Ser Ile Gly Thr Val Ile Tyr Gln Cys Leu 
        195                 200                 205             


Val Gly Lys Pro Pro Phe Gln Ala Asn Ser Pro Gln Asp Leu Arg Met 
    210                 215                 220                 


Phe Tyr Glu Lys Asn Arg Ser Leu Met Pro Ser Ile Pro Arg Glu Thr 
225                 230                 235                 240 


Ser Pro Tyr Leu Ala Asn Leu Leu Leu Gly Leu Leu Gln Arg Asn Gln 
                245                 250                 255     


Lys Asp Arg Met Asp Phe Glu Ala Phe Phe Ser His Pro Phe Leu Glu 
            260                 265                 270         


Gln Gly Pro Val Lys Lys Ser Cys Pro Val Pro Val Pro Met Tyr Ser 
        275                 280                 285             


Gly Ser Val Ser Gly Ser Ser Cys Gly Ser Ser Pro Ser Cys Arg Phe 
    290                 295                 300                 


Ala Ser Pro Pro Ser Leu Pro Asp Met Gln His Ile Gln Glu Glu Asn 
305                 310                 315                 320 


Leu Ser Ser Pro Pro Leu Gly Pro Pro Asn Tyr Leu Gln Val Ser Lys 
                325                 330                 335     


Asp Ser Ala Ser Thr Ser Ser Lys Asn Ser Ser Cys Asp Thr Asp Asp 
            340                 345                 350         


Phe Val Leu Val Pro His Asn Ile Ser Ser Asp His Ser Cys Asp Met 
        355                 360                 365             


Pro Met Gly Thr Ala Gly Arg Arg Ala Ser Asn Glu Phe Leu Val Cys 
    370                 375                 380                 


Gly Gly Gln Cys Gln Pro Thr Val Ser Pro His Ser Glu Thr Ala Pro 
385                 390                 395                 400 


Ile Pro Val Pro Thr Gln Ile Arg Asn Tyr Gln Arg Ile Glu Gln Asn 
                405                 410                 415     


Leu Thr Ser Thr Ala Ser Ser Gly Thr Asn Val His Gly Ser Pro Arg 
            420                 425                 430         


Ser Ala Val Val Arg Arg Ser Asn Thr Ser Pro Met Gly Phe Leu Arg 
        435                 440                 445             


Pro Gly Ser Cys Ser Pro Val Pro Ala Asp Thr Ala Gln Thr Val Gly 
    450                 455                 460                 


Arg Arg Leu Ser Thr Gly Ser Ser Arg Pro Tyr Ser Pro Ser Pro Leu 
465                 470                 475                 480 


Val Gly Thr Ile Pro Glu Gln Phe Ser Gln Cys Cys Cys Gly His Pro 
                485                 490                 495     


Gln Gly His Asp Ser Arg Ser Arg Asn Ser Ser Gly Ser Pro Val Pro 
            500                 505                 510         


Gln Ala Gln Ser Pro Gln Ser Leu Leu Ser Gly Ala Arg Leu Gln Ser 
        515                 520                 525             


Ala Pro Thr Leu Thr Asp Ile Tyr Gln Asn Lys Gln Lys Leu Arg Lys 
    530                 535                 540                 


Gln His Ser Asp Pro Val Cys Pro Ser His Thr Gly Ala Gly Tyr Ser 
545                 550                 555                 560 


Tyr Ser Pro Gln Pro Ser Arg Pro Gly Ser Leu Gly Thr Ser Pro Thr 
                565                 570                 575     


Lys His Leu Gly Ser Ser Pro Arg Ser Ser Asp Trp Phe Phe Lys Thr 
            580                 585                 590         


Pro Leu Pro Thr Ile Ile Gly Ser Pro Thr Lys Thr Thr Ala Pro Phe 
        595                 600                 605             


Lys Ile Pro Lys Thr Gln Ala Ser Ser Asn Leu Leu Ala Leu Val Thr 
    610                 615                 620                 


Arg His Gly Pro Ala Glu Glu Gln Ser Lys Asp Gly Asn Glu Pro Arg 
625                 630                 635                 640 


Glu Cys Ala His Cys Leu Leu Val Gln Gly Ser Glu Arg Gln Arg Ala 
                645                 650                 655     


Glu Gln Gln Ser Lys Ala Val Phe Gly Arg Ser Val Ser Thr Gly Lys 
            660                 665                 670         


Leu Ser Asp Gln Gln Gly Lys Thr Pro Ile Cys Arg His Gln Gly Ser 
        675                 680                 685             


Thr Asp Ser Leu Asn Thr Glu Arg Pro Met Asp Ile Ala Pro Ala Gly 
    690                 695                 700                 


Ala Cys Gly Gly Val Leu Ala Pro Pro Ala Gly Thr Ala Ala Ser Ser 
705                 710                 715                 720 


Lys Ala Val Leu Phe Thr Val Gly Ser Pro Pro His Ser Ala Ala Ala 
                725                 730                 735     


Pro Thr Cys Thr His Met Phe Leu Arg Thr Arg Thr Thr Ser Val Gly 
            740                 745                 750         


Pro Ser Asn Ser Gly Gly Ser Leu Cys Ala Met Ser Gly Arg Val Cys 
        755                 760                 765             


Val Gly Ser Pro Pro Gly Pro Gly Phe Gly Ser Ser Pro Pro Gly Ala 
    770                 775                 780                 


Glu Ala Ala Pro Ser Leu Arg Tyr Val Pro Tyr Gly Ala Ser Pro Pro 
785                 790                 795                 800 


Ser Leu Glu Gly Leu Ile Thr Phe Glu Ala Pro Glu Leu Pro Glu Glu 
                805                 810                 815     


Thr Leu Met Glu Arg Glu His Thr Asp Thr Leu Arg His Leu Asn Val 
            820                 825                 830         


Met Leu Met Phe Thr Glu Cys Val Leu Asp Leu Thr Ala Met Arg Gly 
        835                 840                 845             


Gly Asn Pro Glu Leu Cys Thr Ser Ala Val Ser Leu Tyr Gln Ile Gln 
    850                 855                 860                 


Glu Ser Val Val Val Asp Gln Ile Ser Gln Leu Ser Lys Asp Trp Gly 
865                 870                 875                 880 


Trp Val Glu Gln Leu Val Leu Tyr Met Lys Ala Ala Gln Leu Leu Ala 
                885                 890                 895     


Ala Ser Leu His Leu Ala Lys Ala Gln Ile Lys Ser Gly Lys Leu Ser 
            900                 905                 910         


Pro Ser Thr Ala Val Lys Gln Val Val Lys Asn Leu Asn Glu Arg Tyr 
        915                 920                 925             


Lys Phe Cys Ile Thr Met Cys Lys Lys Leu Thr Glu Lys Leu Asn Arg 
    930                 935                 940                 


Phe Phe Ser Asp Lys Gln Arg Phe Ile Asp Glu Ile Asn Ser Val Thr 
945                 950                 955                 960 


Ala Glu Lys Leu Ile Tyr Asn Cys Ala Val Glu Met Val Gln Ser Ala 
                965                 970                 975     


Ala Leu Asp Glu Met Phe Gln Gln Thr Glu Asp Ile Val Tyr Arg Tyr 
            980                 985                 990         


His Lys Ala Ala Leu Leu Leu Glu  Gly Leu Ser Arg Ile  Leu Gln Asp 
        995                 1000                 1005             


Pro Ala  Asp Ile Glu Asn Val  His Lys Tyr Lys Cys  Ser Ile Glu 
    1010                 1015                 1020             


Arg Arg  Leu Ser Ala Leu Cys  His Ser Thr Ala Thr  Val 
    1025                 1030                 1035     


<210>  31
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Leu Arg Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr 
1               5                   10                  15      


Leu Arg Glu Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met 
            20                  25                  30          


Phe Asn Glu Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu 
        35                  40                  45              


Asp Ser Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu 
    50                  55                  60                  


Glu Ser Lys Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn 
65                  70                  75                  80  


Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu 
                85                  90                  95      


Leu Leu Lys Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Leu Leu 
            100                 105                 110         


Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His 
        115                 120                 125             


Pro Ala Phe Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln 
    130                 135                 140                 


Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg 
145                 150                 155                 160 


Phe Ser His Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu 
                165                 170                 175     


Tyr Glu Ile Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg 
            180                 185                 190         


Pro His Asp Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg 
        195                 200                 205             


Lys Asp Ser Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly 
    210                 215                 220                 


Leu Ala Ser Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu 
225                 230                 235                 240 


Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu 
                245                 250                 255     


Thr Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp 
            260                 265                 270         


Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Thr Glu Glu Val Glu 
        275                 280                 285             


Ala Ile Leu Asn Gly Asp Val Asn Phe Gln Val Trp Ser Asp His His 
    290                 295                 300                 


Arg Pro Ser Leu Ser Arg Ile Lys Leu Ala Ile Lys Tyr Glu Val Lys 
305                 310                 315                 320 


Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Met Trp 
                325                 330                 335     


Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Ser Ile Ala Val Lys Phe 
            340                 345                 350         


Leu Ala Val Phe Gly Val Ser Ile Gly Leu Pro Phe Leu Ala Ile Ala 
        355                 360                 365             


Tyr Trp Ile Ala Pro Cys Ser Lys Leu Gly Arg Thr Leu Arg Ser Pro 
    370                 375                 380                 


Phe Met Lys Phe Val Ala His Ala Val Ser Phe Thr Ile Phe Leu Gly 
385                 390                 395                 400 


Leu Leu Val Val Asn Ala Ser Asp Arg Phe Glu Gly Val Lys Thr Leu 
                405                 410                 415     


Pro Asn Glu Thr Phe Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys 
            420                 425                 430         


Thr Thr Gln Phe Ser Trp Thr Glu Met Leu Ile Met Lys Trp Val Leu 
        435                 440                 445             


Gly Met Ile Trp Ser Glu Cys Lys Glu Ile Trp Glu Glu Gly Pro Arg 
    450                 455                 460                 


Glu Tyr Val Leu His Leu Trp Asn Leu Leu Asp Phe Gly Met Leu Ser 
465                 470                 475                 480 


Ile Phe Val Ala Ser Phe Thr Ala Arg Phe Met Ala Phe Leu Lys Ala 
                485                 490                 495     


Thr Glu Ala Gln Leu Tyr Val Asp Gln His Val Gln Asp Asp Thr Leu 
            500                 505                 510         


His Asn Val Ser Leu Pro Pro Glu Val Ala Tyr Phe Thr Tyr Ala Arg 
        515                 520                 525             


Asp Lys Trp Trp Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr 
    530                 535                 540                 


Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro 
545                 550                 555                 560 


Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val 
                565                 570                 575     


Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala 
            580                 585                 590         


Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Arg Gly Ala Lys 
        595                 600                 605             


Tyr Asn Pro Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe 
    610                 615                 620                 


Trp Ser Ile Phe Gly Leu Ser Glu Val Ile Ser Val Val Leu Lys Tyr 
625                 630                 635                 640 


Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr 
                645                 650                 655     


Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile 
            660                 665                 670         


Asn Asn Ser Tyr Gln Glu Ile Glu Glu Asp Ala Asp Val Glu Trp Lys 
        675                 680                 685             


Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Glu Gly Arg Thr 
    690                 695                 700                 


Leu Pro Ala Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Phe Tyr Tyr 
705                 710                 715                 720 


Leu Ile Met Arg Ile Lys Met Cys Leu Ile Lys Leu Cys Lys Ser Lys 
                725                 730                 735     


Ala Lys Ser Cys Glu Asn Asp Leu Glu Met Gly Met Leu Asn Ser Lys 
            740                 745                 750         


Phe Lys Lys Thr Arg Tyr Gln Ala Gly Met Arg Asn Ser Glu Asn Leu 
        755                 760                 765             


Thr Ala Asn Asn Thr Leu Ser Lys Pro Thr Arg Tyr Gln Lys Ile Met 
    770                 775                 780                 


Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Arg Glu 
785                 790                 795                 800 


Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile 
                805                 810                 815     


Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser Gln Ala Thr Gly 
            820                 825                 830         


Glu Leu Ala Asp Leu Ile Gln Gln Leu Ser Glu Lys Phe Gly Lys Asn 
        835                 840                 845             


Leu Asn Lys Asp His Leu Arg Val Asn Lys Gly Lys Asp Ile 
    850                 855                 860         


<210>  32
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Thr Lys Val Arg Lys Cys Lys Glu Gln Ala Arg Val Thr Phe 
1               5                   10                  15      


Pro Ala Pro Glu Glu Glu Glu Asp Glu Gly Glu Asp Glu Gly Ala Glu 
            20                  25                  30          


Pro Gln Arg Arg Arg Arg Gly Trp Arg Gly Val Asn Gly Gly Leu Glu 
        35                  40                  45              


Pro Arg Ser Ala Pro Ser Gln Arg Glu Pro His Gly Tyr Cys Pro Pro 
    50                  55                  60                  


Pro Phe Ser His Gly Pro Asp Leu Ser Met Glu Gly Ser Pro Ser Leu 
65                  70                  75                  80  


Arg Arg Met Thr Val Met Arg Glu Lys Gly Arg Arg Gln Ala Val Arg 
                85                  90                  95      


Gly Pro Ala Phe Met Phe Asn Asp Arg Gly Thr Ser Leu Thr Ala Glu 
            100                 105                 110         


Glu Glu Arg Phe Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val 
        115                 120                 125             


Arg Lys Met Leu Glu Glu Ser Lys Thr Leu Asn Val Asn Cys Val Asp 
    130                 135                 140                 


Tyr Met Gly Gln Asn Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu 
145                 150                 155                 160 


Glu Val Thr Glu Leu Leu Leu Lys Lys Glu Asn Leu Ala Arg Ile Gly 
                165                 170                 175     


Asp Ala Leu Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu 
            180                 185                 190         


Ala Ile Leu Asn His Pro Gly Phe Ala Ala Ser Lys Arg Leu Thr Leu 
        195                 200                 205             


Ser Pro Cys Glu Gln Glu Leu Gln Asp Asp Asp Phe Tyr Ala Tyr Asp 
    210                 215                 220                 


Glu Asp Gly Thr Arg Phe Ser Pro Asp Ile Thr Pro Ile Ile Leu Ala 
225                 230                 235                 240 


Ala His Cys Gln Lys Tyr Glu Val Val His Met Leu Leu Met Lys Gly 
                245                 250                 255     


Ala Arg Ile Glu Arg Pro His Asp Tyr Phe Cys Lys Cys Gly Asp Cys 
            260                 265                 270         


Met Glu Lys Gln Arg His Asp Ser Phe Ser His Ser Arg Ser Arg Ile 
        275                 280                 285             


Asn Ala Tyr Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser 
    290                 295                 300                 


Glu Asp Pro Val Leu Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Lys 
305                 310                 315                 320 


Leu Ala Asn Ile Glu Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser 
                325                 330                 335     


Met Gln Cys Lys Asp Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp 
            340                 345                 350         


Ser Glu Glu Val Glu Ala Ile Leu Asn Gly Asp Leu Glu Ser Ala Glu 
        355                 360                 365             


Pro Leu Glu Val His Arg His Lys Ala Ser Leu Ser Arg Val Lys Leu 
    370                 375                 380                 


Ala Ile Lys Tyr Glu Val Lys Lys Phe Val Ala His Pro Asn Cys Gln 
385                 390                 395                 400 


Gln Gln Leu Leu Thr Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Glu 
                405                 410                 415     


Gln Thr Ile Ala Ile Lys Cys Leu Val Val Leu Val Val Ala Leu Gly 
            420                 425                 430         


Leu Pro Phe Leu Ala Ile Gly Tyr Trp Ile Ala Pro Cys Ser Arg Leu 
        435                 440                 445             


Gly Lys Ile Leu Arg Ser Pro Phe Met Lys Phe Val Ala His Ala Ala 
    450                 455                 460                 


Ser Phe Ile Ile Phe Leu Gly Leu Leu Val Phe Asn Ala Ser Asp Arg 
465                 470                 475                 480 


Phe Glu Gly Ile Thr Thr Leu Pro Asn Ile Thr Val Thr Asp Tyr Pro 
                485                 490                 495     


Lys Gln Ile Phe Arg Val Lys Thr Thr Gln Phe Thr Trp Thr Glu Met 
            500                 505                 510         


Leu Ile Met Val Trp Val Leu Gly Met Met Trp Ser Glu Cys Lys Glu 
        515                 520                 525             


Leu Trp Leu Glu Gly Pro Arg Glu Tyr Ile Leu Gln Leu Trp Asn Val 
    530                 535                 540                 


Leu Asp Phe Gly Met Leu Ser Ile Phe Ile Ala Ala Phe Thr Ala Arg 
545                 550                 555                 560 


Phe Leu Ala Phe Leu Gln Ala Thr Lys Ala Gln Gln Tyr Val Asp Ser 
                565                 570                 575     


Tyr Val Gln Glu Ser Asp Leu Ser Glu Val Thr Leu Pro Pro Glu Ile 
            580                 585                 590         


Gln Tyr Phe Thr Tyr Ala Arg Asp Lys Trp Leu Pro Ser Asp Pro Gln 
        595                 600                 605             


Ile Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser 
    610                 615                 620                 


Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln 
625                 630                 635                 640 


Ile Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Leu 
                645                 650                 655     


Phe Ile Met Val Phe Phe Ala Phe Met Ile Gly Met Phe Ile Leu Tyr 
            660                 665                 670         


Ser Tyr Tyr Leu Gly Ala Lys Val Asn Ala Ala Phe Thr Thr Val Glu 
        675                 680                 685             


Glu Ser Phe Lys Thr Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu Val 
    690                 695                 700                 


Thr Ser Val Val Leu Lys Tyr Asp His Lys Phe Ile Glu Asn Ile Gly 
705                 710                 715                 720 


Tyr Val Leu Tyr Gly Ile Tyr Asn Val Thr Met Val Val Val Leu Leu 
                725                 730                 735     


Asn Met Leu Ile Ala Met Ile Asn Ser Ser Tyr Gln Glu Ile Glu Asp 
            740                 745                 750         


Asp Ser Asp Val Glu Trp Lys Phe Ala Arg Ser Lys Leu Trp Leu Ser 
        755                 760                 765             


Tyr Phe Asp Asp Gly Lys Thr Leu Pro Pro Pro Phe Ser Leu Val Pro 
    770                 775                 780                 


Ser Pro Lys Ser Phe Val Tyr Phe Ile Met Arg Ile Val Asn Phe Pro 
785                 790                 795                 800 


Lys Cys Arg Arg Arg Arg Leu Gln Lys Asp Ile Glu Met Gly Met Gly 
                805                 810                 815     


Asn Ser Lys Ser Arg Leu Asn Leu Phe Thr Gln Ser Asn Ser Arg Val 
            820                 825                 830         


Phe Glu Ser His Ser Phe Asn Ser Ile Leu Asn Gln Pro Thr Arg Tyr 
        835                 840                 845             


Gln Gln Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln 
    850                 855                 860                 


Val Asp Lys Glu Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile 
865                 870                 875                 880 


Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Asp Lys Ser 
                885                 890                 895     


Gln Ala Thr Glu Glu Leu Ala Ile Leu Ile His Lys Leu Ser Glu Lys 
            900                 905                 910         


Leu Asn Pro Ser Met Leu Arg Cys Glu 
        915                 920     


<210>  33
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Glu Gly Ser Pro Ser Leu Arg Arg Met Thr Val Met Arg Glu Lys 
1               5                   10                  15      


Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met Phe Asn Asp Arg 
            20                  25                  30          


Gly Thr Ser Leu Thr Ala Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu 
        35                  40                  45              


Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu Glu Ser Lys Thr 
    50                  55                  60                  


Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu 
65                  70                  75                  80  


Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu Leu Leu Lys Lys 
                85                  90                  95      


Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys 
            100                 105                 110         


Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His Pro Gly Phe Ala 
        115                 120                 125             


Ala Ser Lys Arg Leu Thr Leu Ser Pro Cys Glu Gln Glu Leu Gln Asp 
    130                 135                 140                 


Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg Phe Ser Pro Asp 
145                 150                 155                 160 


Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Lys Tyr Glu Val Val 
                165                 170                 175     


His Met Leu Leu Met Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr 
            180                 185                 190         


Phe Cys Lys Cys Gly Asp Cys Met Glu Lys Gln Arg His Asp Ser Phe 
        195                 200                 205             


Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro 
    210                 215                 220                 


Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu Thr Ala Leu Glu 
225                 230                 235                 240 


Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu Lys Glu Phe Lys 
                245                 250                 255     


Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly 
            260                 265                 270         


Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu Ala Ile Leu Asn 
        275                 280                 285             


Gly Asp Leu Glu Ser Ala Glu Pro Leu Glu Val His Arg His Lys Ala 
    290                 295                 300                 


Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu Val Lys Lys Phe 
305                 310                 315                 320 


Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Ile Trp Tyr Glu 
                325                 330                 335     


Asn Leu Ser Gly Leu Arg Glu Gln Thr Ile Ala Ile Lys Cys Leu Val 
            340                 345                 350         


Val Leu Val Val Ala Leu Gly Leu Pro Phe Leu Ala Ile Gly Tyr Trp 
        355                 360                 365             


Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile Leu Arg Ser Pro Phe Met 
    370                 375                 380                 


Lys Phe Val Ala His Ala Ala Ser Phe Ile Ile Phe Leu Gly Leu Leu 
385                 390                 395                 400 


Val Phe Asn Ala Ser Asp Arg Phe Glu Gly Ile Thr Thr Leu Pro Asn 
                405                 410                 415     


Ile Thr Val Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys Thr Thr 
            420                 425                 430         


Gln Phe Thr Trp Thr Glu Met Leu Ile Met Val Trp Val Leu Gly Met 
        435                 440                 445             


Met Trp Ser Glu Cys Lys Glu Leu Trp Leu Glu Gly Pro Arg Glu Tyr 
    450                 455                 460                 


Ile Leu Gln Leu Trp Asn Val Leu Asp Phe Gly Met Leu Ser Ile Phe 
465                 470                 475                 480 


Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala Phe Leu Gln Ala Thr Lys 
                485                 490                 495     


Ala Gln Gln Tyr Val Asp Ser Tyr Val Gln Glu Ser Asp Leu Ser Glu 
            500                 505                 510         


Val Thr Leu Pro Pro Glu Ile Gln Tyr Phe Thr Tyr Ala Arg Asp Lys 
        515                 520                 525             


Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr Ala Ile 
    530                 535                 540                 


Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro Ala Asn 
545                 550                 555                 560 


Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val Lys Asp 
                565                 570                 575     


Ile Phe Lys Phe Met Val Leu Phe Ile Met Val Phe Phe Ala Phe Met 
            580                 585                 590         


Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr Leu Gly Ala Lys Val Asn 
        595                 600                 605             


Ala Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe Trp Ser 
    610                 615                 620                 


Ile Phe Gly Leu Ser Glu Val Thr Ser Val Val Leu Lys Tyr Asp His 
625                 630                 635                 640 


Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Ile Tyr Asn Val 
                645                 650                 655     


Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile Asn Ser 
            660                 665                 670         


Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp Val Glu Trp Lys Phe Ala 
        675                 680                 685             


Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp Asp Gly Lys Thr Leu Pro 
    690                 695                 700                 


Pro Pro Phe Ser Leu Val Pro Ser Pro Lys Ser Phe Val Tyr Phe Ile 
705                 710                 715                 720 


Met Arg Ile Val Asn Phe Pro Lys Cys Arg Arg Arg Arg Leu Gln Lys 
                725                 730                 735     


Asp Ile Glu Met Gly Met Gly Asn Ser Lys Ser Arg Leu Asn Leu Phe 
            740                 745                 750         


Thr Gln Ser Asn Ser Arg Val Phe Glu Ser His Ser Phe Asn Ser Ile 
        755                 760                 765             


Leu Asn Gln Pro Thr Arg Tyr Gln Gln Ile Met Lys Arg Leu Ile Lys 
    770                 775                 780                 


Arg Tyr Val Leu Lys Ala Gln Val Asp Lys Glu Asn Asp Glu Val Asn 
785                 790                 795                 800 


Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr 
                805                 810                 815     


Glu Leu Leu Glu Asp Lys Ser Gln Ala Thr Glu Glu Leu Ala Ile Leu 
            820                 825                 830         


Ile His Lys Leu Ser Glu Lys Leu Asn Pro Ser Met Leu Arg Cys Glu 
        835                 840                 845             


<210>  34
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Thr Ala Ala Ile Arg Arg Gln Arg Glu Leu Ser Ile Leu Pro Lys 
1               5                   10                  15      


Val Thr Leu Glu Ala Met Asn Thr Thr Val Met Gln Gly Phe Asn Arg 
            20                  25                  30          


Ser Glu Arg Cys Pro Arg Asp Thr Arg Ile Val Gln Leu Val Phe Pro 
        35                  40                  45              


Ala Leu Tyr Thr Val Val Phe Leu Thr Gly Ile Leu Leu Asn Thr Leu 
    50                  55                  60                  


Ala Leu Trp Val Phe Val His Ile Pro Ser Ser Ser Thr Phe Ile Ile 
65                  70                  75                  80  


Tyr Leu Lys Asn Thr Leu Val Ala Asp Leu Ile Met Thr Leu Met Leu 
                85                  90                  95      


Pro Phe Lys Ile Leu Ser Asp Ser His Leu Ala Pro Trp Gln Leu Arg 
            100                 105                 110         


Ala Phe Val Cys Arg Phe Ser Ser Val Ile Phe Tyr Glu Thr Met Tyr 
        115                 120                 125             


Val Gly Ile Val Leu Leu Gly Leu Ile Ala Phe Asp Arg Phe Leu Lys 
    130                 135                 140                 


Ile Ile Arg Pro Leu Arg Asn Ile Phe Leu Lys Lys Pro Val Phe Ala 
145                 150                 155                 160 


Lys Thr Val Ser Ile Phe Ile Trp Phe Phe Leu Phe Phe Ile Ser Leu 
                165                 170                 175     


Pro Asn Thr Ile Leu Ser Asn Lys Glu Ala Thr Pro Ser Ser Val Lys 
            180                 185                 190         


Lys Cys Ala Ser Leu Lys Gly Pro Leu Gly Leu Lys Trp His Gln Met 
        195                 200                 205             


Val Asn Asn Ile Cys Gln Phe Ile Phe Trp Thr Val Phe Ile Leu Met 
    210                 215                 220                 


Leu Val Phe Tyr Val Val Ile Ala Lys Lys Val Tyr Asp Ser Tyr Arg 
225                 230                 235                 240 


Lys Ser Lys Ser Lys Asp Arg Lys Asn Asn Lys Lys Leu Glu Gly Lys 
                245                 250                 255     


Val Phe Val Val Val Ala Val Phe Phe Val Cys Phe Ala Pro Phe His 
            260                 265                 270         


Phe Ala Arg Val Pro Tyr Thr His Ser Gln Thr Asn Asn Lys Thr Asp 
        275                 280                 285             


Cys Arg Leu Gln Asn Gln Leu Phe Ile Ala Lys Glu Thr Thr Leu Phe 
    290                 295                 300                 


Leu Ala Ala Thr Asn Ile Cys Met Asp Pro Leu Ile Tyr Ile Phe Leu 
305                 310                 315                 320 


Cys Lys Lys Phe Thr Glu Lys Leu Pro Cys Met Gln Gly Arg Lys Thr 
                325                 330                 335     


Thr Ala Ser Ser Gln Glu Asn His Ser Ser Gln Thr Asp Asn Ile Thr 
            340                 345                 350         


Leu Gly 
        


<210>  35
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Asn Thr Thr Val Met Gln Gly Phe Asn Arg Ser Glu Arg Cys Pro 
1               5                   10                  15      


Arg Asp Thr Arg Ile Val Gln Leu Val Phe Pro Ala Leu Tyr Thr Val 
            20                  25                  30          


Val Phe Leu Thr Gly Ile Leu Leu Asn Thr Leu Ala Leu Trp Val Phe 
        35                  40                  45              


Val His Ile Pro Ser Ser Ser Thr Phe Ile Ile Tyr Leu Lys Asn Thr 
    50                  55                  60                  


Leu Val Ala Asp Leu Ile Met Thr Leu Met Leu Pro Phe Lys Ile Leu 
65                  70                  75                  80  


Ser Asp Ser His Leu Ala Pro Trp Gln Leu Arg Ala Phe Val Cys Arg 
                85                  90                  95      


Phe Ser Ser Val Ile Phe Tyr Glu Thr Met Tyr Val Gly Ile Val Leu 
            100                 105                 110         


Leu Gly Leu Ile Ala Phe Asp Arg Phe Leu Lys Ile Ile Arg Pro Leu 
        115                 120                 125             


Arg Asn Ile Phe Leu Lys Lys Pro Val Phe Ala Lys Thr Val Ser Ile 
    130                 135                 140                 


Phe Ile Trp Phe Phe Leu Phe Phe Ile Ser Leu Pro Asn Thr Ile Leu 
145                 150                 155                 160 


Ser Asn Lys Glu Ala Thr Pro Ser Ser Val Lys Lys Cys Ala Ser Leu 
                165                 170                 175     


Lys Gly Pro Leu Gly Leu Lys Trp His Gln Met Val Asn Asn Ile Cys 
            180                 185                 190         


Gln Phe Ile Phe Trp Thr Val Phe Ile Leu Met Leu Val Phe Tyr Val 
        195                 200                 205             


Val Ile Ala Lys Lys Val Tyr Asp Ser Tyr Arg Lys Ser Lys Ser Lys 
    210                 215                 220                 


Asp Arg Lys Asn Asn Lys Lys Leu Glu Gly Lys Val Phe Val Val Val 
225                 230                 235                 240 


Ala Val Phe Phe Val Cys Phe Ala Pro Phe His Phe Ala Arg Val Pro 
                245                 250                 255     


Tyr Thr His Ser Gln Thr Asn Asn Lys Thr Asp Cys Arg Leu Gln Asn 
            260                 265                 270         


Gln Leu Phe Ile Ala Lys Glu Thr Thr Leu Phe Leu Ala Ala Thr Asn 
        275                 280                 285             


Ile Cys Met Asp Pro Leu Ile Tyr Ile Phe Leu Cys Lys Lys Phe Thr 
    290                 295                 300                 


Glu Lys Leu Pro Cys Met Gln Gly Arg Lys Thr Thr Ala Ser Ser Gln 
305                 310                 315                 320 


Glu Asn His Ser Ser Gln Thr Asp Asn Ile Thr Leu Gly 
                325                 330             


<210>  36
<211>  1104
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Phe Arg Ala Ala Arg Leu Ser Met Arg Asn Arg Arg Asn Asp 
1               5                   10                  15      


Thr Leu Asp Ser Thr Arg Thr Leu Tyr Ser Ser Ala Ser Arg Ser Thr 
            20                  25                  30          


Asp Leu Ser Tyr Ser Glu Ser Asp Leu Val Asn Phe Ile Gln Ala Asn 
        35                  40                  45              


Phe Lys Lys Arg Glu Cys Val Phe Phe Thr Lys Asp Ser Lys Ala Thr 
    50                  55                  60                  


Glu Asn Val Cys Lys Cys Gly Tyr Ala Gln Ser Gln His Met Glu Gly 
65                  70                  75                  80  


Thr Gln Ile Asn Gln Ser Glu Lys Trp Asn Tyr Lys Lys His Thr Lys 
                85                  90                  95      


Glu Phe Pro Thr Asp Ala Phe Gly Asp Ile Gln Phe Glu Thr Leu Gly 
            100                 105                 110         


Lys Lys Gly Lys Tyr Ile Arg Leu Ser Cys Asp Thr Asp Ala Glu Ile 
        115                 120                 125             


Leu Tyr Glu Leu Leu Thr Gln His Trp His Leu Lys Thr Pro Asn Leu 
    130                 135                 140                 


Val Ile Ser Val Thr Gly Gly Ala Lys Asn Phe Ala Leu Lys Pro Arg 
145                 150                 155                 160 


Met Arg Lys Ile Phe Ser Arg Leu Ile Tyr Ile Ala Gln Ser Lys Gly 
                165                 170                 175     


Ala Trp Ile Leu Thr Gly Gly Thr His Tyr Gly Leu Met Lys Tyr Ile 
            180                 185                 190         


Gly Glu Val Val Arg Asp Asn Thr Ile Ser Arg Ser Ser Glu Glu Asn 
        195                 200                 205             


Ile Val Ala Ile Gly Ile Ala Ala Trp Gly Met Val Ser Asn Arg Asp 
    210                 215                 220                 


Thr Leu Ile Arg Asn Cys Asp Ala Glu Gly Tyr Phe Leu Ala Gln Tyr 
225                 230                 235                 240 


Leu Met Asp Asp Phe Thr Arg Asp Pro Leu Tyr Ile Leu Asp Asn Asn 
                245                 250                 255     


His Thr His Leu Leu Leu Val Asp Asn Gly Cys His Gly His Pro Thr 
            260                 265                 270         


Val Glu Ala Lys Leu Arg Asn Gln Leu Glu Lys Tyr Ile Ser Glu Arg 
        275                 280                 285             


Thr Ile Gln Asp Ser Asn Tyr Gly Gly Lys Ile Pro Ile Val Cys Phe 
    290                 295                 300                 


Ala Gln Gly Gly Gly Lys Glu Thr Leu Lys Ala Ile Asn Thr Ser Ile 
305                 310                 315                 320 


Lys Asn Lys Ile Pro Cys Val Val Val Glu Gly Ser Gly Gln Ile Ala 
                325                 330                 335     


Asp Val Ile Ala Ser Leu Val Glu Val Glu Asp Ala Leu Thr Ser Ser 
            340                 345                 350         


Ala Val Lys Glu Lys Leu Val Arg Phe Leu Pro Arg Thr Val Ser Arg 
        355                 360                 365             


Leu Pro Glu Glu Glu Thr Glu Ser Trp Ile Lys Trp Leu Lys Glu Ile 
    370                 375                 380                 


Leu Glu Cys Ser His Leu Leu Thr Val Ile Lys Met Glu Glu Ala Gly 
385                 390                 395                 400 


Asp Glu Ile Val Ser Asn Ala Ile Ser Tyr Ala Leu Tyr Lys Ala Phe 
                405                 410                 415     


Ser Thr Ser Glu Gln Asp Lys Asp Asn Trp Asn Gly Gln Leu Lys Leu 
            420                 425                 430         


Leu Leu Glu Trp Asn Gln Leu Asp Leu Ala Asn Asp Glu Ile Phe Thr 
        435                 440                 445             


Asn Asp Arg Arg Trp Glu Ser Ala Asp Leu Gln Glu Val Met Phe Thr 
    450                 455                 460                 


Ala Leu Ile Lys Asp Arg Pro Lys Phe Val Arg Leu Phe Leu Glu Asn 
465                 470                 475                 480 


Gly Leu Asn Leu Arg Lys Phe Leu Thr His Asp Val Leu Thr Glu Leu 
                485                 490                 495     


Phe Ser Asn His Phe Ser Thr Leu Val Tyr Arg Asn Leu Gln Ile Ala 
            500                 505                 510         


Lys Asn Ser Tyr Asn Asp Ala Leu Leu Thr Phe Val Trp Lys Leu Val 
        515                 520                 525             


Ala Asn Phe Arg Arg Gly Phe Arg Lys Glu Asp Arg Asn Gly Arg Asp 
    530                 535                 540                 


Glu Met Asp Ile Glu Leu His Asp Val Ser Pro Ile Thr Arg His Pro 
545                 550                 555                 560 


Leu Gln Ala Leu Phe Ile Trp Ala Ile Leu Gln Asn Lys Lys Glu Leu 
                565                 570                 575     


Ser Lys Val Ile Trp Glu Gln Thr Arg Gly Cys Thr Leu Ala Ala Leu 
            580                 585                 590         


Gly Ala Ser Lys Leu Leu Lys Thr Leu Ala Lys Val Lys Asn Asp Ile 
        595                 600                 605             


Asn Ala Ala Gly Glu Ser Glu Glu Leu Ala Asn Glu Tyr Glu Thr Arg 
    610                 615                 620                 


Ala Val Glu Leu Phe Thr Glu Cys Tyr Ser Ser Asp Glu Asp Leu Ala 
625                 630                 635                 640 


Glu Gln Leu Leu Val Tyr Ser Cys Glu Ala Trp Gly Gly Ser Asn Cys 
                645                 650                 655     


Leu Glu Leu Ala Val Glu Ala Thr Asp Gln His Phe Ile Ala Gln Pro 
            660                 665                 670         


Gly Val Gln Asn Phe Leu Ser Lys Gln Trp Tyr Gly Glu Ile Ser Arg 
        675                 680                 685             


Asp Thr Lys Asn Trp Lys Ile Ile Leu Cys Leu Phe Ile Ile Pro Leu 
    690                 695                 700                 


Val Gly Cys Gly Phe Val Ser Phe Arg Lys Lys Pro Val Asp Lys His 
705                 710                 715                 720 


Lys Lys Leu Leu Trp Tyr Tyr Val Ala Phe Phe Thr Ser Pro Phe Val 
                725                 730                 735     


Val Phe Ser Trp Asn Val Val Phe Tyr Ile Ala Phe Leu Leu Leu Phe 
            740                 745                 750         


Ala Tyr Val Leu Leu Met Asp Phe His Ser Val Pro His Pro Pro Glu 
        755                 760                 765             


Leu Val Leu Tyr Ser Leu Val Phe Val Leu Phe Cys Asp Glu Val Arg 
    770                 775                 780                 


Gln Trp Tyr Val Asn Gly Val Asn Tyr Phe Thr Asp Leu Trp Asn Val 
785                 790                 795                 800 


Met Asp Thr Leu Gly Leu Phe Tyr Phe Ile Ala Gly Ile Val Phe Arg 
                805                 810                 815     


Leu His Ser Ser Asn Lys Ser Ser Leu Tyr Ser Gly Arg Val Ile Phe 
            820                 825                 830         


Cys Leu Asp Tyr Ile Ile Phe Thr Leu Arg Leu Ile His Ile Phe Thr 
        835                 840                 845             


Val Ser Arg Asn Leu Gly Pro Lys Ile Ile Met Leu Gln Arg Met Leu 
    850                 855                 860                 


Ile Asp Val Phe Phe Phe Leu Phe Leu Phe Ala Val Trp Met Val Ala 
865                 870                 875                 880 


Phe Gly Val Ala Arg Gln Gly Ile Leu Arg Gln Asn Glu Gln Arg Trp 
                885                 890                 895     


Arg Trp Ile Phe Arg Ser Val Ile Tyr Glu Pro Tyr Leu Ala Met Phe 
            900                 905                 910         


Gly Gln Val Pro Ser Asp Val Asp Gly Thr Thr Tyr Asp Phe Ala His 
        915                 920                 925             


Cys Thr Phe Thr Gly Asn Glu Ser Lys Pro Leu Cys Val Glu Leu Asp 
    930                 935                 940                 


Glu His Asn Leu Pro Arg Phe Pro Glu Trp Ile Thr Ile Pro Leu Val 
945                 950                 955                 960 


Cys Ile Tyr Met Leu Ser Thr Asn Ile Leu Leu Val Asn Leu Leu Val 
                965                 970                 975     


Ala Met Phe Gly Tyr Thr Val Gly Thr Val Gln Glu Asn Asn Asp Gln 
            980                 985                 990         


Val Trp Lys Phe Gln Arg Tyr Phe  Leu Val Gln Glu Tyr  Cys Ser Arg 
        995                 1000                 1005             


Leu Asn  Ile Pro Phe Pro Phe  Ile Val Phe Ala Tyr  Phe Tyr Met 
    1010                 1015                 1020             


Val Val  Lys Lys Cys Phe Lys  Cys Cys Cys Lys Glu  Lys Asn Met 
    1025                 1030                 1035             


Glu Ser  Ser Val Cys Cys Phe  Lys Asn Glu Asp Asn  Glu Thr Leu 
    1040                 1045                 1050             


Ala Trp  Glu Gly Val Met Lys  Glu Asn Tyr Leu Val  Lys Ile Asn 
    1055                 1060                 1065             


Thr Lys  Ala Asn Asp Thr Ser  Glu Glu Met Arg His  Arg Phe Arg 
    1070                 1075                 1080             


Gln Leu  Asp Thr Lys Leu Asn  Asp Leu Lys Gly Leu  Leu Lys Glu 
    1085                 1090                 1095             


Ile Ala  Asn Lys Ile Lys 
    1100                 


<210>  37
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr 
            20                  25                  30          


Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser 
        35                  40                  45              


Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn 
    50                  55                  60                  


Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg 
                85                  90                  95      


Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro 
            100                 105                 110         


Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu 
        115                 120                 125             


Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Val Asp Ile Gly 
145                 150                 155                 160 


Asp Arg Ile Met Lys Leu Asn Thr Glu Ile Arg Asp Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Leu Thr Val 
        195                 200                 205             


Arg Asn Leu Ala Gln Phe Pro Asp Thr Ile Thr Gly Ala Asp Thr Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Ser Cys Val Asn Asn Ser Glu Glu Lys 
225                 230                 235                 240 


Asp Val Pro Lys Met Tyr Cys Gly Ala Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Asn Cys Leu Cys Asn Ala Gly His Glu Glu Arg Ser Gly Glu 
            260                 265                 270         


Cys Gln Ala Cys Lys Ile Gly Tyr Tyr Lys Ala Leu Ser Thr Asp Ala 
        275                 280                 285             


Thr Cys Ala Lys Cys Pro Pro His Ser Tyr Ser Val Trp Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Thr Cys Asp Arg Gly Phe Phe Arg Ala Asp Asn Asp Ala 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro Leu Asn Leu Ile 
                325                 330                 335     


Ser Asn Val Asn Glu Thr Ser Val Asn Leu Glu Trp Ser Ser Pro Gln 
            340                 345                 350         


Asn Thr Gly Gly Arg Gln Asp Ile Ser Tyr Asn Val Val Cys Lys Lys 
        355                 360                 365             


Cys Gly Ala Gly Asp Pro Ser Lys Cys Arg Pro Cys Gly Ser Gly Val 
    370                 375                 380                 


His Tyr Thr Pro Gln Gln Asn Gly Leu Lys Thr Thr Lys Val Ser Ile 
385                 390                 395                 400 


Thr Asp Leu Leu Ala His Thr Asn Tyr Thr Phe Glu Ile Trp Ala Val 
                405                 410                 415     


Asn Gly Val Ser Lys Tyr Asn Pro Asn Pro Asp Gln Ser Val Ser Val 
            420                 425                 430         


Thr Val Thr Thr Asn Gln Ala Ala Pro Ser Ser Ile Ala Leu Val Gln 
        435                 440                 445             


Ala Lys Glu Val Thr Arg Tyr Ser Val Ala Leu Ala Trp Leu Glu Pro 
    450                 455                 460                 


Asp Arg Pro Asn Gly Val Ile Leu Glu Tyr Glu Val Lys Tyr Tyr Glu 
465                 470                 475                 480 


Lys Asp Gln Asn Glu Arg Ser Tyr Arg Ile Val Arg Thr Ala Ala Arg 
                485                 490                 495     


Asn Thr Asp Ile Lys Gly Leu Asn Pro Leu Thr Ser Tyr Val Phe His 
            500                 505                 510         


Val Arg Ala Arg Thr Ala Ala Gly Tyr Gly Asp Phe Ser Glu Pro Leu 
        515                 520                 525             


Glu Val Thr Thr Asn Thr Val Pro Ser Arg Ile Ile Gly Asp Gly Ala 
    530                 535                 540                 


Asn Ser Thr Val Leu Leu Val Ser Val Ser Gly Ser Val Val Leu Val 
545                 550                 555                 560 


Val Ile Leu Ile Ala Ala Phe Val Ile Ser Arg Arg Arg Ser Lys Tyr 
                565                 570                 575     


Ser Lys Ala Lys Gln Glu Ala Asp Glu Glu Lys His Leu Asn Gln Gly 
            580                 585                 590         


Val Arg Thr Tyr Val Asp Pro Phe Thr Tyr Glu Asp Pro Asn Gln Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ala Ser Cys Ile Lys Ile Glu 
    610                 615                 620                 


Lys Val Ile Gly Val Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Val Pro Gly Lys Arg Glu Ile Cys Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ala Gly Tyr Thr Asp Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Cys Lys Pro Val Met Ile Ile Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ala Phe Leu Arg Lys Asn Asp Gly Arg Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Gly Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Met Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Ile Glu Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ile Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu 
    850                 855                 860                 


Arg Ser Asp Arg Pro Lys Phe Gly Gln Ile Val Asn Met Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Asn Ser Leu Lys Arg Thr Gly Thr Glu Ser Ser 
                885                 890                 895     


Arg Pro Asn Thr Ala Leu Leu Asp Pro Ser Ser Pro Glu Phe Ser Ala 
            900                 905                 910         


Val Val Ser Val Gly Asp Trp Leu Gln Ala Ile Lys Met Asp Arg Tyr 
        915                 920                 925             


Lys Asp Asn Phe Thr Ala Ala Gly Tyr Thr Thr Leu Glu Ala Val Val 
    930                 935                 940                 


His Val Asn Gln Glu Asp Leu Ala Arg Ile Gly Ile Thr Ala Ile Thr 
945                 950                 955                 960 


His Gln Asn Lys Ile Leu Ser Ser Val Gln Ala Met Arg Thr Gln Met 
                965                 970                 975     


Gln Gln Met His Gly Arg Met Val Pro Val 
            980                 985     


<210>  38
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asn Trp Ser His Ser Cys Ile Ser Phe Cys Trp Ile Tyr Phe Ala 
1               5                   10                  15      


Ala Ser Arg Leu Arg Ala Ala Glu Thr Ala Asp Gly Lys Tyr Ala Gln 
            20                  25                  30          


Lys Leu Phe Asn Asp Leu Phe Glu Asp Tyr Ser Asn Ala Leu Arg Pro 
        35                  40                  45              


Val Glu Asp Thr Asp Lys Val Leu Asn Val Thr Leu Gln Ile Thr Leu 
    50                  55                  60                  


Ser Gln Ile Lys Asp Met Asp Glu Arg Asn Gln Ile Leu Thr Ala Tyr 
65                  70                  75                  80  


Leu Trp Ile Arg Gln Ile Trp His Asp Ala Tyr Leu Thr Trp Asp Arg 
                85                  90                  95      


Asp Gln Tyr Asp Gly Leu Asp Ser Ile Arg Ile Pro Ser Asp Leu Val 
            100                 105                 110         


Trp Arg Pro Asp Ile Val Leu Tyr Asn Lys Ala Asp Asp Glu Ser Ser 
        115                 120                 125             


Glu Pro Val Asn Thr Asn Val Val Leu Arg Tyr Asp Gly Leu Ile Thr 
    130                 135                 140                 


Trp Asp Ala Pro Ala Ile Thr Lys Ser Ser Cys Val Val Asp Val Thr 
145                 150                 155                 160 


Tyr Phe Pro Phe Asp Asn Gln Gln Cys Asn Leu Thr Phe Gly Ser Trp 
                165                 170                 175     


Thr Tyr Asn Gly Asn Gln Val Asp Ile Phe Asn Ala Leu Asp Ser Gly 
            180                 185                 190         


Asp Leu Ser Asp Phe Ile Glu Asp Val Glu Trp Glu Val His Gly Met 
        195                 200                 205             


Pro Ala Val Lys Asn Val Ile Ser Tyr Gly Cys Cys Ser Glu Pro Tyr 
    210                 215                 220                 


Pro Asp Val Thr Phe Thr Leu Leu Leu Lys Arg Arg Ser Ser Phe Tyr 
225                 230                 235                 240 


Ile Val Asn Leu Leu Ile Pro Cys Val Leu Ile Ser Phe Leu Ala Pro 
                245                 250                 255     


Leu Ser Phe Tyr Leu Pro Ala Ala Ser Gly Glu Lys Val Ser Leu Gly 
            260                 265                 270         


Val Thr Ile Leu Leu Ala Met Thr Val Phe Gln Leu Met Val Ala Glu 
        275                 280                 285             


Ile Met Pro Ala Ser Glu Asn Val Pro Leu Ile Gly Lys Tyr Tyr Ile 
    290                 295                 300                 


Ala Thr Met Ala Leu Ile Thr Ala Ser Thr Ala Leu Thr Ile Met Val 
305                 310                 315                 320 


Met Asn Ile His Phe Cys Gly Ala Glu Ala Arg Pro Val Pro His Trp 
                325                 330                 335     


Ala Arg Val Val Ile Leu Lys Tyr Met Ser Arg Val Leu Phe Val Tyr 
            340                 345                 350         


Asp Val Gly Glu Ser Cys Leu Ser Pro His His Ser Arg Glu Arg Asp 
        355                 360                 365             


His Leu Thr Lys Val Tyr Ser Lys Leu Pro Glu Ser Asn Leu Lys Ala 
    370                 375                 380                 


Ala Arg Asn Lys Asp Leu Ser Arg Lys Lys Asp Met Asn Lys Arg Leu 
385                 390                 395                 400 


Lys Asn Asp Leu Gly Cys Gln Gly Lys Asn Pro Gln Glu Ala Glu Ser 
                405                 410                 415     


Tyr Cys Ala Gln Tyr Lys Val Leu Thr Arg Asn Ile Glu Tyr Ile Ala 
            420                 425                 430         


Lys Cys Leu Lys Asp His Lys Ala Thr Asn Ser Lys Gly Ser Glu Trp 
        435                 440                 445             


Lys Lys Val Ala Lys Val Ile Asp Arg Phe Phe Met Trp Ile Phe Phe 
    450                 455                 460                 


Ile Met Val Phe Val Met Thr Ile Leu Ile Ile Ala Arg Ala Asp 
465                 470                 475                 


<210>  39
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  39
ggctgagtgt ggacatgac                                                    19


<210>  40
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  40
tctgttctct ggccgtgac                                                    19


<210>  41
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  41
acctcccaag atgaagctc                                                    19


<210>  42
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  42
ctatacccag tttctagtc                                                    19


<210>  43
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  43
tgtttgagct agccaattc                                                    19


<210>  44
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  44
atccacagga aatgaagac                                                    19


<210>  45
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  45
aatgatgaat gatcaactc                                                    19


<210>  46
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  46
ataggcatgt catctatgc                                                    19


<210>  47
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  47
tgtttgagct agccaattc                                                    19


<210>  48
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  48
aatgatgaat gatcaactc                                                    19


<210>  49
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  49
ataggcatgt catctatgc                                                    19


<210>  50
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  50
atccacagga aatgaagac                                                    19


<210>  51
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  51
tgaccttcct gatcgattc                                                    19


<210>  52
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  52
ctatgatgct ggcttatac                                                    19


<210>  53
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  53
ggatgggaca aagacagac                                                    19


<210>  54
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  54
ggacttcact gctcagtgc                                                    19


<210>  55
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  55
cgtatgagct acctggagc                                                    19


<210>  56
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  56
tgtgaagccc tccaatgtc                                                    19


<210>  57
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  57
ccagaagggc tacaatgtc                                                    19


<210>  58
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  58
tacagtgagg acattgtgc                                                    19


<210>  59
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  59
tgatcacgct gctcaacac                                                    19


<210>  60
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  60
tgacactgac agccattgc                                                    19


<210>  61
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  61
atacagtccc tctctgtgc                                                    19


<210>  62
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  62
gcaataatag caacaattc                                                    19


<210>  63
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  63
caatcattgg ctctcctac                                                    19


<210>  64
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  64
gaaggcctaa gtaggattc                                                    19


<210>  65
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  65
ttcaggaatt acccaactc                                                    19


<210>  66
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  66
tcaccttatt tggctaatc                                                    19


<210>  67
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  67
gttcgttgct catcctaac                                                    19


<210>  68
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  68
caagaccctt aacttcaac                                                    19


<210>  69
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  69
cggcttatct gaagtaatc                                                    19


<210>  70
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  70
aagtggtggc cttcagacc                                                    19


<210>  71
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  71
gtccaggtta aacctcttc                                                    19


<210>  72
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  72
taagggagca gaccatagc                                                    19


<210>  73
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  73
tgacagattc ctcaagatc                                                    19


<210>  74
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  74
tatggatccc ttaatatac                                                    19


<210>  75
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  75
acgcccaact cttgaagtc                                                    19


<210>  76
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  76
tggaagatta tcctgtgtc                                                    19


<210>  77
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  77
aggcatcgat ttagacaac                                                    19


<210>  78
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  78
tgaagaacga catcaatgc                                                    19


<210>  79
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  79
cttgggtgga tagcaagcc                                                    19


<210>  80
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  80
aagttacctt attggattc                                                    19


<210>  81
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  81
gaacttgatt tcaaatgtc                                                    19


<210>  82
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  82
tggtggcaga aatcatgcc                                                    19


<210>  83
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  83
ttcgtccagt ggaagatac                                                    19


<210>  84
<211>  12
<212>  RNA
<213>  artificial

<220>
<223>  Loop Sequence

<400>  84
guuugcuaua ac                                                           12


<210>  85
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  85
ccgtttacgt ggagactcgc c                                                 21


<210>  86
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  86
cccccacctt atatatattc tttcc                                             25


