<110> Migone et al.
<120> Use of B Lymphocyte Stimulator Protein Antagonists to Promote Transplantation Tolerance
<130> 706005
<150> 61/152,155 
<151> 2009-02-12
<160> 61
<210> 1
<211> 1100
<212> DNA
<213> Homo sapiens
<220>  
<221> CDS
<222> (147)..(1001)
<400> 1
      aaattcagga taactctcct gaggggtgag ccaagccctg ccatgtagtg cacgcaggac 60
      atcaacaaac acagataaca ggaaatgatc cattccctgt ggtcacttat tctaaaggcc 120
      ccaaccttca aagttcaagt agtgat atg gat gac tcc aca gaa agg gag cag  173
                                   Met Asp Asp Ser Thr Glu Arg Glu Gln
                                     1               5
      tca cgc ctt act tct tgc ctt aag aaa aga gaa gaa atg aaa ctg aag   221
      Ser Arg Leu Thr Ser Cys Leu Lys Lys Arg Glu Glu Met Lys Leu Lys
       10                  15                  20                  25
      gag tgt gtt tcc atc ctc cca cgg aag gaa agc ccc tct gtc cga tcc   269
      Glu Cys Val Ser Ile Leu Pro Arg Lys Glu Ser Pro Ser Val Arg Ser
                       30                  35                  40
      tcc aaa gac gga aag ctg ctg gct gca acc ttg ctg ctg gca ctg ctg   317
      Ser Lys Asp Gly Lys Leu Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu
                   45                  50                  55
      tct tgc tgc ctc acg gtg gtg tct ttc tac cag gtg gcc gcc ctg caa   365
      Ser Cys Cys Leu Thr Val Val Ser Phe Tyr Gln Val Ala Ala Leu Gln
               60                  65                  70
      ggg gac ctg gcc agc ctc cgg gca gag ctg cag ggc cac cac gcg gag   413
      Gly Asp Leu Ala Ser Leu Arg Ala Glu Leu Gln Gly His His Ala Glu
           75                  80                  85
      aag ctg cca gca gga gca gga gcc ccc aag gcc ggc ctg gag gaa gct   461
      Lys Leu Pro Ala Gly Ala Gly Ala Pro Lys Ala Gly Leu Glu Glu Ala
       90                  95                 100                 105
      cca gct gtc acc gcg gga ctg aaa atc ttt gaa cca cca gct cca gga   509
      Pro Ala Val Thr Ala Gly Leu Lys Ile Phe Glu Pro Pro Ala Pro Gly
                      110                 115                 120
      gaa ggc aac tcc agt cag aac agc aga aat aag cgt gcc gtt cag ggt   557
      Glu Gly Asn Ser Ser Gln Asn Ser Arg Asn Lys Arg Ala Val Gln Gly
                  125                 130                 135
      cca gaa gaa aca gtc act caa gac tgc ttg caa ctg att gca gac agt   605
      Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp Ser
              140                 145                 150
      gaa aca cca act ata caa aaa gga tct tac aca ttt gtt cca tgg ctt   653
      Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp Leu
          155                 160                 165
      ctc agc ttt aaa agg gga agt gcc cta gaa gaa aaa gag aat aaa ata   701
      Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys Ile
      170                 175                 180                 185
      ttg gtc aaa gaa act ggt tac ttt ttt ata tat ggt cag gtt tta tat   749
      Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu Tyr
                      190                 195                 200
      act gat aag acc tac gcc atg gga cat cta att cag agg aag aag gtc   797
      Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg Lys Lys Val
                  205                 210                 215
      cat gtc ttt ggg gat gaa ttg agt ctg gtg act ttg ttt cga tgt att   845
      His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile
              220                 225                 230
      caa aat atg cct gaa aca cta ccc aat aat tcc tgc tat tca gct ggc   893
      Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly
          235                 240                 245
      att gca aaa ctg gaa gaa gga gat gaa ctc caa ctt gca ata cca aga   941
      Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro Arg
      250                 255                 260                 265
      gaa aat gca caa ata tca ctg gat gga gat gtc aca ttt ttt ggt gca   989
      Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe Phe Gly Ala
                      270                 275                 280
      ttg aaa ctg ctg tgacctactt acaccatgtc tgtagctatt ttcctccctt       1041
      Leu Lys Leu Leu
                  285
      tctctgtacc tctaagaaga aagaatctaa ctgaaaatac caaaaaaaaa aaaaaaaaa  1100

<210> 2
<211> 285
<212> PRT
<213> Homo sapiens
<400> 2
      Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu
        1               5                  10                  15
      Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro
                   20                  25                  30
      Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu
               35                  40                  45
      Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val
           50                  55                  60
      Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg
       65                  70                  75                  80
      Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly
                       85                  90                  95
      Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu
                  100                 105                 110
      Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn
              115                 120                 125
      Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln
          130                 135                 140
      Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys
      145                 150                 155                 160
      Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser
                      165                 170                 175
      Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr
                  180                 185                 190
      Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met
              195                 200                 205
      Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu
          210                 215                 220
      Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu
      225                 230                 235                 240
      Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly
                      245                 250                 255
      Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu
                  260                 265                 270
      Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu
              275                 280                 285

<210> 3
<211> 233
<212> PRT
<213> Homo sapiens
<400> 3
      Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala
        1               5                  10                  15
      Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe
                   20                  25                  30
      Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe
               35                  40                  45
      Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro
           50                  55                  60
      Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser
       65                  70                  75                  80
      Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro
                       85                  90                  95
      Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu
                  100                 105                 110
      Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser
              115                 120                 125
      Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly
          130                 135                 140
      Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala
      145                 150                 155                 160
      Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro
                      165                 170                 175
      Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu
                  180                 185                 190
      Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu
              195                 200                 205
      Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly
          210                 215                 220
      Gln Val Tyr Phe Gly Ile Ile Ala Leu
      225                 230

<210> 4
<211> 205
<212> PRT
<213> Homo sapiens
<400> 4
      Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Arg Gly Thr Thr
        1               5                  10                  15
      Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala
                   20                  25                  30
      Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala
               35                  40                  45
      Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala
           50                  55                  60
      Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg
       65                  70                  75                  80
      Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn
                       85                  90                  95
      Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln
                  100                 105                 110
      Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro
              115                 120                 125
      Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe
          130                 135                 140
      His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln
      145                 150                 155                 160
      Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr
                      165                 170                 175
      Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val
                  180                 185                 190
      Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu
              195                 200                 205

<210> 5
<211> 244
<212> PRT
<213> Homo sapiens
<400> 5
      Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg
        1               5                  10                  15
      Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu
                   20                  25                  30
      Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro
               35                  40                  45
      Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln
           50                  55                  60
      Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu
       65                  70                  75                  80
      Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro
                       85                  90                  95
      Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe
                  100                 105                 110
      Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro
              115                 120                 125
      Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg
          130                 135                 140
      Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg
      145                 150                 155                 160
      Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu
                      165                 170                 175
      Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala
                  180                 185                 190
      Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly
              195                 200                 205
      Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser
          210                 215                 220
      His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala
      225                 230                 235                 240
      Val Met Val Gly

<210> 6
<211> 281
<212> PRT
<213> Homo sapiens
<400> 6
      Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp
        1               5                  10                  15
      Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys
                   20                  25                  30
      Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro
               35                  40                  45
      Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro
           50                  55                  60
      Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly
       65                  70                  75                  80
      Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly
                       85                  90                  95
      Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala
                  100                 105                 110
      Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu
              115                 120                 125
      Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg
          130                 135                 140
      Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu
      145                 150                 155                 160
      Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr
                      165                 170                 175
      Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr
                  180                 185                 190
      Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser
              195                 200                 205
      His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met
          210                 215                 220
      Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala
      225                 230                 235                 240
      Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His
                      245                 250                 255
      Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser
                  260                 265                 270
      Gln Thr Phe Phe Gly Leu Tyr Lys Leu
              275                 280

<210> 7
<211> 338
<212> DNA
<213> Homo sapiens
<220>  
<223> Description of Combined DNA/RNA Molecule: n equals
      a, t, g, or c
<220>  
<221> misc_feature
<222> (3)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (58)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (67)..(71)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (212)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (255)
<223> n equals a, t, g or c
<220>  
<221> misc_feature
<222> (297)
<223> n equals a, t, g or c
<220>  
<221> misc_feature
<222> (300)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (320)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (335)
<223> n equals a, t, g, or c
<400> 7
      aggntaactc tcctgagggg tgagccaagc cctgccatgt agtgcacgca ggacatcanc 60
      aaacacannn nncaggaaat aatccattcc ctgtggtcac ttattctaaa ggccccaacc 120
      ttcaaagttc aagtagtgat atggatgact ccacagaaag ggagcagtca cgccttactt 180
      cttgccttaa gaaaagagaa gaaatgaaac tgnaaggagt gtgtttccat cctcccacgg 240
      aaggaaagcc cctctntccg atcctccaaa gacggaaagc tgctggctgc aaccttgntg 300
      ntggcattgt gttcttgctg nctcaaggtg gtgttntt                         338

<210> 8
<211> 509
<212> DNA
<213> Homo sapiens
<220>  
<223> Description of Combined DNA/RNA Molecule: n equals
      a, t, g, or c
<220>  
<221> misc_feature
<222> (10)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (13)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (209)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (315)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (322)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (325)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (334)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (343)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (347)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (351)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (356)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (409)..(410)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (416)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (422)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (424)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (426)..(427)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (429)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (431)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (433)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (438)..(439)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (443)..(444)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (446)..(447)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (449)..(450)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (452)..(453)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (458)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (461)..(462)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (466)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (469)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (471)..(472)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (474)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (478)..(481)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (496)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (498)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (504)
<223> n equals a, t, g, or c
<400> 8
      aattcggcan agnaaactgg ttactttttt atatatggtc aggttttata tactgataag 60
      acctacgcca tgggacatct agttcagagg aagaaggtcc atgtctttgg ggatgaattg 120
      agtctggtga ctttgtttcg atgtattcaa aatatgcctg aaacactacc caataattcc 180
      tgctattcag ctggcattgc aaaactggna ggaaggagat gaactccaac ttgcaatacc 240
      aggggaaaat gcacaattat cactgggatg gagatgttca cattttttgg gtgccattga 300
      aactgctgtg acctncttac ancangtgct gttngctatt ttncctncct nttctntggt 360
      aacctcttag gaaggaagga ttcttaactg ggaaataacc caaaaaaann ttaaangggt 420
      angngnnana ngnggggnng ttnncnngnn gnnttttngg nntatnttnt nntngggnnn 480
      ngtaaaaatg gggccnangg gggnttttt                                   509

<210> 9
<211> 497
<212> DNA
<213> Homo sapiens
<220>  
<221> misc_feature
<222> (168)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (213)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (288)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (325)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (346)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (406)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (415)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (419)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (437)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (442)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (467)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (473)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (476)
<223> n equals a, t, g, or c
<220>  
<221> misc_feature
<222> (481)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (483)..(484)
<223> n equals a, t, g, or c
<220> 
<221> misc_feature
<222> (494)
<223> n equals a, t, g, or c
<400> 9
      aattcggcac gagcaaggcc ggcctggagg aagctccagc tgtcaccgcg ggactgaaaa 60
      tctttgaacc accagctcca ggagaaggca actccagtca gaacagcaga aataagcgtg 120
      ccgttcaggg tccagaagaa acagtcactc aagactgctt gcaactgntt gcagacagtg 180
      aaacaccaac tatacaaaaa ggctcccttc tgntgccaca tttgggccaa ggaatggaga 240
      gatttcttcg tctggaaaca ttttgccaaa ctcttcagat actctttnct ctctgggaat 300
      caaaggaaaa tctctactta gattnacaca tttgttccca tgggtntctt aagttttaaa 360
      aggggagtgc ccttaggagg aaaaggggat aaatattggc caaggnactg gttantttnt 420
      aaatatggtc aggtttntat anctggtagg cctcgccatg ggcattnatt canggngagg 480
      ncnntctttt gggntga                                                497

<210> 10
<211> 27
<212> DNA
<213> Homo sapiens
<220>  
<223> Neutrokine-alpha forward primer containing BamHI
      restriction site
<400> 10
      gtgggatcca gcctccgggc agagctg                                     27

<210> 11
<211> 33
<212> DNA
<213> Homo sapiens
<220>  
<223> Neutrokine-alpha reverse primer containing HindIII
      restriction site and sequence complementary to two
      stop codons
<400> 11
      gtgaagcttt tattacagca gtttcaatgc acc                              33

<210> 12
<211> 26
<212> DNA
<213> Homo sapiens
<220>  
<223> Neutrokine-alpha forward primer containing BspHI
      restriction site
<400> 12
      gtgtcatgag cctccgggca gagctg                                      26

<210> 13
<211> 33
<212> DNA
<213> Homo sapiens
<220> 
<223> Neutrokine-alpha reverse primer containing HindIII
      restriction site and sequence complementary to two
      stop codons
<400> 13
      gtgaagcttt tattacagca gtttcaatgc acc                              33

<210> 14
<211> 28
<212> DNA
<213> Homo sapiens
<220> 
<223> Neutrokine-alpha forward primer containing
      BamHI restriction site
<400> 14
      gtgggatccc cgggcagagc tgcagggc                                    28

<210> 15
<211> 33
<212> DNA
<213> Homo sapiens
<220> 
<223> Neutrokine-alpha reverse primer containing BamHI
      restriction site and sequence complementary to two
      stop codons
<400> 15
      gtgggatcct tattacagca gtttcaatgc acc                              33

<210> 16
<211> 129
<212> DNA
<213> Homo sapiens
<220> 
<223> Neutrokine-alpha forward primer containing a Bam HI
      restriction site, Kozak sequence, AUG start codon,
      and sequence encoding the secretory leader peptide of
      human IL-6 gene
<400> 16
      gcgggatccg ccaccatgaa ctccttctcc acaagcgcct tcggtccagt tgccttctcc 60
      ctggggctgc tcctggtgtt gcctgctgcc ttccctgccc cagttgtgag acaaggggac 120
      ctggccagc                                                         129

<210> 17
<211> 30
<212> DNA
<213> Homo sapiens
<220> 
<223> Neutrokine-alpha reverse primerconating BamHI
      restriction site
<400> 17
      gtgggatcct tacagcagtt tcaatgcacc                                  30

<210> 18
<211> 903
<212> DNA
<213> Homo sapiens
<220>  
<221> CDS
<222> (1)..(798)
<400> 18
      atg gat gac tcc aca gaa agg gag cag tca cgc ctt act tct tgc ctt   48
      Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu
        1               5                  10                  15
      aag aaa aga gaa gaa atg aaa ctg aag gag tgt gtt tcc atc ctc cca   96
      Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro
                   20                  25                  30
      cgg aag gaa agc ccc tct gtc cga tcc tcc aaa gac gga aag ctg ctg   144
      Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu
               35                  40                  45
      gct gca acc ttg ctg ctg gca ctg ctg tct tgc tgc ctc acg gtg gtg   192
      Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val
           50                  55                  60
      tct ttc tac cag gtg gcc gcc ctg caa ggg gac ctg gcc agc ctc cgg   240
      Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg
       65                  70                  75                  80
      gca gag ctg cag ggc cac cac gcg gag aag ctg cca gca gga gca gga   288
      Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly
                       85                  90                  95
      gcc ccc aag gcc ggc ctg gag gaa gct cca gct gtc acc gcg gga ctg   336
      Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu
                  100                 105                 110
      aaa atc ttt gaa cca cca gct cca gga gaa ggc aac tcc agt cag aac   384
      Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn
              115                 120                 125
      agc aga aat aag cgt gcc gtt cag ggt cca gaa gaa aca gga tct tac   432
      Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Gly Ser Tyr
          130                 135                 140
      aca ttt gtt cca tgg ctt ctc agc ttt aaa agg gga agt gcc cta gaa   480
      Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu
      145                 150                 155                 160
      gaa aaa gag aat aaa ata ttg gtc aaa gaa act ggt tac ttt ttt ata   528
      Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile
                      165                 170                 175
      tat ggt cag gtt tta tat act gat aag acc tac gcc atg gga cat cta   576
      Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu
                  180                 185                 190
      att cag agg aag aag gtc cat gtc ttt ggg gat gaa ttg agt ctg gtg   624
      Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val
              195                 200                 205
      act ttg ttt cga tgt att caa aat atg cct gaa aca cta ccc aat aat   672
      Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn
          210                 215                 220
      tcc tgc tat tca gct ggc att gca aaa ctg gaa gaa gga gat gaa ctc   720
      Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu
      225                 230                 235                 240
      caa ctt gca ata cca aga gaa aat gca caa ata tca ctg gat gga gat   768
      Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp
                      245                 250                 255
      gtc aca ttt ttt ggt gca ttg aaa ctg ctg tgacctactt acaccatgtc     818
      Val Thr Phe Phe Gly Ala Leu Lys Leu Leu
                  260                 265
      tgtagctatt ttcctccctt tctctgtacc tctaagaaga aagaatctaa ctgaaaatac 878
      caaaaaaaaa aaaaaaaaaa aaaaa                                       903

<210> 19
<211> 266
<212> PRT
<213> Homo sapiens
<400> 19
      Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu
        1               5                  10                  15
      Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro
                   20                  25                  30
      Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu
               35                  40                  45
      Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val
           50                  55                  60
      Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg
       65                  70                  75                  80
      Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly
                       85                  90                  95
      Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu
                  100                 105                 110
      Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn
              115                 120                 125
      Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Gly Ser Tyr
          130                 135                 140
      Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu
      145                 150                 155                 160
      Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile
                      165                 170                 175
      Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu
                  180                 185                 190
      Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val
              195                 200                 205
      Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn
          210                 215                 220
      Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu
      225                 230                 235                 240
      Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp
                      245                 250                 255
      Val Thr Phe Phe Gly Ala Leu Lys Leu Leu
                  260                 265

<210> 20
<211> 136
<212> PRT
<213> Homo sapiens
<400> 20
      His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp Asp
        1               5                  10                  15
      Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly Arg
                   20                  25                  30
      Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly Val
               35                  40                  45
      Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr Met
           50                  55                  60
      Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe
       65                  70                  75                  80
      Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn Ser
                       85                  90                  95
      Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu Ser
                  100                 105                 110
      Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His Gly
              115                 120                 125
      Thr Phe Leu Gly Phe Val Lys Leu
          130                 135

<210> 21
<211> 462
<212> DNA
<213> Homo sapiens
<400> 21
      atggctgttc agggtccgga agaaaccgtt actcaggact gccttcagct gatcgcagac 60
      tctgaaactc cgaccatcca gaaaggttct tacacctttg ttccttggct gctttctttc 120
      aaacgtggtt ctgccctgga agagaaagaa aacaaaatcc tggttaaaga aactggttac 180
      ttctttatct acggtcaggt tctttacact gataagacct acgccatggg tcacctgatt 240
      cagcgtaaga aagttcacgt tttcggtgac gagctgtctc tggttactct gtttcgctgc 300
      attcagaaca tgccggaaac tcttcctaac aactcctgct actctgctgg catcgcaaaa 360
      ctggaagagg gtgatgaact gcagctggca attcctcgtg aaaacgcaca aatttctctg 420
      gacggtgatg taaccttctt tggtgcactg aaacttctgt aa                    462

<210> 22
<211> 1040
<212> DNA
<213> Mus musculus
<220>  
<221> CDS
<222> (1)..(468)
<400> 22
      cgc gtg gta gac ctc tca gct cct cct gca cca tgc ctg cct gga tgc   48
      Arg Val Val Asp Leu Ser Ala Pro Pro Ala Pro Cys Leu Pro Gly Cys
        1               5                  10                  15
      cgc cat tct caa cat gat gat aat gga atg aac ctc aga aac aga act   96
      Arg His Ser Gln His Asp Asp Asn Gly Met Asn Leu Arg Asn Arg Thr
                   20                  25                  30
      tac aca ttt gtt cca tgg ctt ctc agc ttt aaa aga gga aat gcc ttg   144
      Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu
               35                  40                  45
      gag gag aaa gag aac aaa ata gtg gtg agg caa aca ggc tat ttc ttc   192
      Glu Glu Lys Glu Asn Lys Ile Val Val Arg Gln Thr Gly Tyr Phe Phe
           50                  55                  60
      atc tac agc cag gtt cta tac acg gac ccc atc ttt gct atg ggt cat   240
      Ile Tyr Ser Gln Val Leu Tyr Thr Asp Pro Ile Phe Ala Met Gly His
       65                  70                  75                  80
      gtc atc cag agg aag aaa gta cac gtc ttt ggg gac gag ctg agc ctg   288
      Val Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu
                       85                  90                  95
      gtg acc ctg ttc cga tgt att cag aat atg ccc aaa aca ctg ccc aac   336
      Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Lys Thr Leu Pro Asn
                  100                 105                 110
      aat tcc tgc tac tcg gct ggc atc gcg agg ctg gaa gaa gga gat gag   384
      Asn Ser Cys Tyr Ser Ala Gly Ile Ala Arg Leu Glu Glu Gly Asp Glu
              115                 120                 125
      att cag ctt gca att cct cgg gag aat gca cag att tca cgc aac gga   432
      Ile Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly
          130                 135                 140
      gac gac acc ttc ttt ggt gcc cta aaa ctg ctg taa ctcacttgct        478
      Asp Asp Thr Phe Phe Gly Ala Leu Lys Leu Leu
      145                 150                 155
      ggagtgcgtg atccccttcc ctcgtcttct ctgtacctcc gagggagaaa cagacgactg 538
      gaaaaactaa aagatgggga aagccgtcag cgaaagtttt ctcgtgaccc gttgaatctg 598
      atccaaacca ggaaatataa cagacagcca caaccgaagt gtgccatgtg agttatgaga 658
      aacggagccc gcgctcagaa agaccggatg aggaagaccg ttttctccag tcctttgcca 718
      acacgcaccg caaccttgct ttttgccttg ggtgacacat gttcagaatg cagggagatt 778
      tccttgtttt gcgatttgcc atgagaagag ggcccacaac tgcaggtcac tgaagcattc 838
      acgctaagtc tcaggattta ctctcccttc tcatgctaag tacacacacg ctcttttcca 898
      ggtaatacta tgggatacta tggaaaggtt gtttgttttt aaatctagaa gtcttgaact 958
      ggcaatagac aaaaatcctt ataaattcaa gtgtaaaata aacttaatta aaaaggttta 1018
      agtgtgaaaa aaaaaaaaaa aa                                          1040

<210> 23
<211> 155
<212> PRT
<213> Mus musculus
<400> 23
      Arg Val Val Asp Leu Ser Ala Pro Pro Ala Pro Cys Leu Pro Gly Cys
        1               5                  10                  15
      Arg His Ser Gln His Asp Asp Asn Gly Met Asn Leu Arg Asn Arg Thr
                   20                  25                  30
      Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu
               35                  40                  45
      Glu Glu Lys Glu Asn Lys Ile Val Val Arg Gln Thr Gly Tyr Phe Phe
           50                  55                  60
      Ile Tyr Ser Gln Val Leu Tyr Thr Asp Pro Ile Phe Ala Met Gly His
       65                  70                  75                  80
      Val Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu
                       85                  90                  95
      Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Lys Thr Leu Pro Asn
                  100                 105                 110
      Asn Ser Cys Tyr Ser Ala Gly Ile Ala Arg Leu Glu Glu Gly Asp Glu
              115                 120                 125
      Ile Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly
          130                 135                 140
      Asp Asp Thr Phe Phe Gly Ala Leu Lys Leu Leu
      145                 150                 155

<210> 24
<211> 26
<212> DNA
<213> Homo sapiens
<400> 24
      ccaccagctc caggagaagg caactc                                      26

<210> 25
<211> 19
<212> DNA
<213> Homo sapiens
<400> 25
      accgcgggac tgaaaatct                                              19

<210> 26
<211> 23
<212> DNA
<213> Homo sapiens
<400> 26
      cacgcttatt tctgctgttc tga                                         23

<210> 27
<211> 657
<212> DNA
<213> Macaca irus
<400> 27
      taccaggtgg cggccgtgca aggggacctg gccagcctcc gggcagagct gcagggccac 60
      cacgcggaga agctgccagc aagagcaaga gcccccaagg ccggtctggg ggaagctcca 120
      gctgtcaccg caggactgaa aatctttgaa ccaccagctc caggagaagg caactccagt 180
      cagagcagca gaaataagcg tgctattcag ggtgcagaag aaacagtcat tcaagactgc 240
      ttgcaactga ttgcagacag tgaaacacca actatacaaa aaggatctta cacatttgtt 300
      ccatggcttc tcagctttaa aaggggaagt gccctagaag aaaaagagaa taaaatattg 360
      gtcaaagaaa ctggttactt ttttatatat ggtcaggttt tatacactga taagacctat 420
      gccatgggac atctaattca gaggaaaaaa gtccatgtct ttggggatga attgagtctg 480
      gtgactttgt ttcgatgtat tcaaaatatg cctgaaacac tacccaataa ttcctgctat 540
      tcagctggca ttgcaaaact ggaagaagga gatgaacttc aacttgcaat accacgagaa 600
      aatgcacaaa tatcactgga tggagatgtc acattttttg gtgccctcaa actgctg    657

<210> 28
<211> 219
<212> PRT
<213> Macaca irus
<400> 28
      Tyr Gln Val Ala Ala Val Gln Gly Asp Leu Ala Ser Leu Arg Ala Glu
        1               5                  10                  15
      Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Arg Ala Arg Ala Pro
                   20                  25                  30
      Lys Ala Gly Leu Gly Glu Ala Pro Ala Val Thr Ala Gly Leu Lys Ile
               35                  40                  45
      Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Ser Ser Arg
           50                  55                  60
      Asn Lys Arg Ala Ile Gln Gly Ala Glu Glu Thr Val Ile Gln Asp Cys
       65                  70                  75                  80
      Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser
                       85                  90                  95
      Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu
                  100                 105                 110
      Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe
              115                 120                 125
      Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His
          130                 135                 140
      Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu
      145                 150                 155                 160
      Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn
                      165                 170                 175
      Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu
                  180                 185                 190
      Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly
              195                 200                 205
      Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu
          210                 215

<210> 29
<211> 657
<212> DNA
<213> Macaca mulatta (Rhesus Monkey)
<400> 29
      taccaggtgg cggccgtgca aggggacctg gccagcctcc gggcagagct gcagagccac 60
      cacgcggaga agctgccagc aagagcaaga gcccccaagg ccggtctggg ggaagctcca 120
      gctgtcaccg cgggactgaa aatctttgaa ccaccagctc caggagaagg caactccagt 180
      cagagcagca gaaataagcg tgctattcag ggtgcagaag aaacagtcat tcaagactgc 240
      ttgcaactga ttgcagacag tgaaacacca actatacaaa aaggatctta cacatttgtt 300
      ccatggcttc tcagctttaa aaggggaagt gccctagaag aaaaagagaa taaaatattg 360
      gtcaaagaaa ctggttactt ttttatatat ggtcaggttt tatacactga taagacctat 420
      gccatgggac atctaattca gaggaaaaaa gtccatgtct ttggggatga attgagtctg 480
      gtgactttgt ttcgatgtat tcaaaatatg cctgaaacac tacccaataa ttcctgctat 540
      tcagctggca ttgcaaaact ggaagaaggg gatgaacttc aacttgcaat accacgagaa 600
      aatgcacaaa tatcactgga tggagatgtc acattttttg gtgccctcaa actgctg    657

<210> 30
<211> 219
<212> PRT
<213> Macaca mulatta (Rhesus Monkey)
<400> 30
      Tyr Gln Val Ala Ala Val Gln Gly Asp Leu Ala Ser Leu Arg Ala Glu
        1               5                  10                  15
      Leu Gln Ser His His Ala Glu Lys Leu Pro Ala Arg Ala Arg Ala Pro
                   20                  25                  30
      Lys Ala Gly Leu Gly Glu Ala Pro Ala Val Thr Ala Gly Leu Lys Ile
               35                  40                  45
      Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Ser Ser Arg
           50                  55                  60
      Asn Lys Arg Ala Ile Gln Gly Ala Glu Glu Thr Val Ile Gln Asp Cys
       65                  70                  75                  80
      Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser
                       85                  90                  95
      Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu
                  100                 105                 110
      Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe
              115                 120                 125
      Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His
          130                 135                 140
      Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu
      145                 150                 155                 160
      Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn
                      165                 170                 175
      Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu
                  180                 185                 190
      Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly
              195                 200                 205
      Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu
          210                 215

<210> 31
<211> 38
<212> DNA
<213> Homo sapiens
<220>  
<223> Neutrokine-alpha forward primer containing sequence
      encoding PSC signal peptide C-terminus
<400> 31
      ggtcgccgtt tctaacgcgg ccgttcaggg tccagaag                         38

<210> 32
<211> 49
<212> DNA
<213> Homo sapiens
<220>  
<223> Reverse primer for amplifying Neutrokine-alpha containing
      reverse complement sequence of the pA2GP vectorand Kpn I
      restriction site
<400> 32
      ctggttcggc ccaaggtacc aagcttgtac cttagatctt ttctagatc             49

<210> 33
<211> 21
<212> DNA
<213> Homo sapiens
<220> 
<223> forward primer that anneals to PSC baculovirus transfer
      plasmid pMGS12
<400> 33
      ctggtagttc ttcggagtgt g                                           21

<210> 34
<211> 19
<212> DNA
<213> Homo sapiens
<220>  
<223> reverse primer that anneals to PSC baculovirus transfer
      plasmid pMGS12
<400> 34
      cgcgttagaa acggcgacc                                              19

<210> 35
<211> 22
<212> DNA
<213> Homo sapiens
<220>  
<221> misc_feature
<222> (7)
<223> n equals deoxyinosine or dideoxyinosine
<220> 
<221> misc_feature
<222> (12)
<223> n equals deoxyinosine or dideoxyinosine
<220> 
<221> misc_feature
<222> (16)
<223> n equals deoxyinosine or dideoxyinosine
<220>  
<223> Neutrokine-alpha degenerate oligonucleotide forward
      primer
<400> 35
      taccagntgg cngccntgca ag                                          22

<210> 36
<211> 22
<212> DNA
<213> Homo sapiens
<220> 
<221> misc_feature
<222> (3)
<223> n equals deoxyinosine or dideoxyinosine
<220>  
<221> misc_feature
<222> (14)
<223> n equals deoxyinosine or dideoxyinosine
<220>  
<221> misc_feature
<222> (16)..(17)
<223> n equals deoxyinosine or dideoxyinosine
<220> 
<223> Neutrokine-alpha degenerate oligonucleotide reverse
      primer
<400> 36
      gtnacagcag tttnanngca cc                                          22

<210> 37
<211> 867
<212> DNA
<213> Mus musculus
<400> 37
      atggatgagt ctgcaaagac cctgccacca ccgtgcctct gtttttgctc cgagaaagga 60
      gaagatatga aagtgggata tgatcccatc actccgcaga aggaggaggg tgcctggttt 120
      gggatctgca gggatggaag gctgctggct gctaccctcc tgctggccct gttgtccagc 180
      agtttcacag cgatgtcctt gtaccagttg gctgccttgc aagcagacct gatgaacctg 240
      cgcatggagc tgcagagcta ccgaggttca gcaacaccag ccgccgcggg tgctccagag 300
      ttgaccgctg gagtcaaact cctgacaccg gcagctcctc gaccccacaa ctccagccgc 360
      ggccacagga acagacgcgc cttccaggga ccagaggaaa cagaacaaga tgtagacctc 420
      tcagctcctc ctgcaccatg cctgcctgga tgccgccatt ctcaacatga tgataatgga 480
      atgaacctca gaaacatcat tcaagactgt ctgcagctga ttgcagacag cgacacgccg 540
      gccttggagg agaaagagaa caaaatagtg gtgaggcaaa caggctattt cttcatctac 600
      agccaggttc tatacacgga ccccatcttt gctatgggtc atgtcatcca gaggaagaaa 660
      gtacacgtct ttggggacga gctgagcctg gtgaccctgt tccgatgtat tcagaatatg 720
      cccaaaacac tgcccaacaa ttcctgctac tcggctggca tcgcgaggct ggaagaagga 780
      gatgagattc agcttgcaat tcctcgggag aatgcacaga tttcacgcaa cggagacgac 840
      accttctttg gtgccctaaa actgctg                                     867

<210> 38
<211> 289
<212> PRT
<213> Mus musculus
<400> 38
      Met Asp Glu Ser Ala Lys Thr Leu Pro Pro Pro Cys Leu Cys Phe Cys
        1               5                  10                  15
      Ser Glu Lys Gly Glu Asp Met Lys Val Gly Tyr Asp Pro Ile Thr Pro
                   20                  25                  30
      Gln Lys Glu Glu Gly Ala Trp Phe Gly Ile Cys Arg Asp Gly Arg Leu
               35                  40                  45
      Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Ser Ser Phe Thr Ala
           50                  55                  60
      Met Ser Leu Tyr Gln Leu Ala Ala Leu Gln Ala Asp Leu Met Asn Leu
       65                  70                  75                  80
      Arg Met Glu Leu Gln Ser Tyr Arg Gly Ser Ala Thr Pro Ala Ala Ala
                       85                  90                  95
      Gly Ala Pro Glu Leu Thr Ala Gly Val Lys Leu Leu Thr Pro Ala Ala
                  100                 105                 110
      Pro Arg Pro His Asn Ser Ser Arg Gly His Arg Asn Arg Arg Ala Phe
              115                 120                 125
      Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala Pro Pro
          130                 135                 140
      Ala Pro Cys Leu Pro Gly Cys Arg His Ser Gln His Asp Asp Asn Gly
      145                 150                 155                 160
      Met Asn Leu Arg Asn Ile Ile Gln Asp Cys Leu Gln Leu Ile Ala Asp
                      165                 170                 175
      Ser Asp Thr Pro Ala Leu Glu Glu Lys Glu Asn Lys Ile Val Val Arg
                  180                 185                 190
      Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu Tyr Thr Asp Pro
              195                 200                 205
      Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys Val His Val Phe
          210                 215                 220
      Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met
      225                 230                 235                 240
      Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Arg
                      245                 250                 255
      Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro Arg Glu Asn Ala
                  260                 265                 270
      Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly Ala Leu Lys Leu
              275                 280                 285
      Leu

<210> 39
<211> 309
<212> PRT
<213> Mus musculus
<400> 39
      Met Asp Glu Ser Ala Lys Thr Leu Pro Pro Pro Cys Leu Cys Phe Cys
        1               5                  10                  15
      Ser Glu Lys Gly Glu Asp Met Lys Val Gly Tyr Asp Pro Ile Thr Pro
                   20                  25                  30
      Gln Lys Glu Glu Gly Ala Trp Phe Gly Ile Cys Arg Asp Gly Arg Leu
               35                  40                  45
      Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Ser Ser Phe Thr Ala
           50                  55                  60
      Met Ser Leu Tyr Gln Leu Ala Ala Leu Gln Ala Asp Leu Met Asn Leu
       65                  70                  75                  80
      Arg Met Glu Leu Gln Ser Tyr Arg Gly Ser Ala Thr Pro Ala Ala Ala
                       85                  90                  95
      Gly Ala Pro Glu Leu Thr Ala Gly Val Lys Leu Leu Thr Pro Ala Ala
                  100                 105                 110
      Pro Arg Pro His Asn Ser Ser Arg Gly His Arg Asn Arg Arg Ala Phe
              115                 120                 125
      Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala Pro Pro
          130                 135                 140
      Ala Pro Cys Leu Pro Gly Cys Arg His Ser Gln His Asp Asp Asn Gly
      145                 150                 155                 160
      Met Asn Leu Arg Asn Ile Ile Gln Asp Cys Leu Gln Leu Ile Ala Asp
                      165                 170                 175
      Ser Asp Thr Pro Thr Ile Arg Lys Gly Thr Tyr Thr Phe Val Pro Trp
                  180                 185                 190
      Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys Glu Asn Lys
              195                 200                 205
      Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu
          210                 215                 220
      Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys
      225                 230                 235                 240
      Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys
                      245                 250                 255
      Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala
                  260                 265                 270
      Gly Ile Ala Arg Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro
              275                 280                 285
      Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly
          290                 295                 300
      Ala Leu Lys Leu Leu
      305

<210> 40
<211> 290
<212> PRT
<213> Mus musculus
<400> 40
      Met Asp Glu Ser Ala Lys Thr Leu Pro Pro Pro Cys Leu Cys Phe Cys
        1               5                  10                  15
      Ser Glu Lys Gly Glu Asp Met Lys Val Gly Tyr Asp Pro Ile Thr Pro
                   20                  25                  30
      Gln Lys Glu Glu Gly Ala Trp Phe Gly Ile Cys Arg Asp Gly Arg Leu
               35                  40                  45
      Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Ser Ser Phe Thr Ala
           50                  55                  60
      Met Ser Leu Tyr Gln Leu Ala Ala Leu Gln Ala Asp Leu Met Asn Leu
       65                  70                  75                  80
      Arg Met Glu Leu Gln Ser Tyr Arg Gly Ser Ala Thr Pro Ala Ala Ala
                       85                  90                  95
      Gly Ala Pro Glu Leu Thr Ala Gly Val Lys Leu Leu Thr Pro Ala Ala
                  100                 105                 110
      Pro Arg Pro His Asn Ser Ser Arg Gly His Arg Asn Arg Arg Ala Phe
              115                 120                 125
      Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala Pro Pro
          130                 135                 140
      Ala Pro Cys Leu Pro Gly Cys Arg His Ser Gln His Asp Asp Asn Gly
      145                 150                 155                 160
      Met Asn Leu Arg Asn Arg Thr Tyr Thr Phe Val Pro Trp Leu Leu Ser
                      165                 170                 175
      Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys Glu Asn Lys Ile Val Val
                  180                 185                 190
      Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu Tyr Thr Asp
              195                 200                 205
      Pro Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys Val His Val
          210                 215                 220
      Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn
      225                 230                 235                 240
      Met Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala
                      245                 250                 255
      Arg Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro Arg Glu Asn
                  260                 265                 270
      Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly Ala Leu Lys
              275                 280                 285
      Leu Leu
          290

<210> 41
<211> 152
<212> PRT
<213> Rattus sp
<400> 41
      Ala Phe Gln Gly Pro Glu Glu Thr Val Ile Gln Asp Cys Leu Gln Leu
        1               5                  10                  15
      Ile Ala Asp Ser Asn Thr Pro Thr Ile Arg Lys Gly Thr Tyr Thr Phe
                   20                  25                  30
      Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys
               35                  40                  45
      Glu Asn Lys Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser
           50                  55                  60
      Gln Val Leu Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln
       65                  70                  75                  80
      Arg Lys Lys Ile His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu
                       85                  90                  95
      Phe Arg Cys Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys
                  100                 105                 110
      Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Val Gln Leu
              115                 120                 125
      Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr
          130                 135                 140
      Phe Phe Gly Ala Leu Lys Leu Leu
      145                 150

<210> 42
<211> 165
<212> PRT
<213> Rattus sp
<400> 42
      Ala Phe Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala
        1               5                  10                  15
      Thr Pro Val Pro Ser Leu Pro Gly Asn Cys His Ala Ser His His Asp
                   20                  25                  30
      Glu Asn Gly Leu Asn Leu Arg Thr Arg Thr Tyr Thr Phe Val Pro Trp
               35                  40                  45
      Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys Glu Asn Lys
           50                  55                  60
      Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu
       65                  70                  75                  80
      Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys
                       85                  90                  95
      Ile His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys
                  100                 105                 110
      Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala
              115                 120                 125
      Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro
          130                 135                 140
      Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly
      145                 150                 155                 160
      Ala Leu Lys Leu Leu
                      165

<210> 43
<211> 184
<212> PRT
<213> Rattus sp
<400> 43
      Ala Phe Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala
        1               5                  10                  15
      Thr Pro Ala Pro Ser Leu Pro Gly Asn Cys His Ala Ser His His Asp
                   20                  25                  30
      Glu Asn Gly Leu Asn Leu Arg Thr Ile Ile Gln Asp Cys Leu Gln Leu
               35                  40                  45
      Ile Ala Asp Ser Asn Thr Pro Thr Ile Arg Lys Gly Thr Tyr Thr Phe
           50                  55                  60
      Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys
       65                  70                  75                  80
      Glu Asn Lys Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser
                       85                  90                  95
      Gln Val Leu Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln
                  100                 105                 110
      Arg Lys Lys Ile His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu
              115                 120                 125
      Phe Arg Cys Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys
          130                 135                 140
      Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Ile Gln Leu
      145                 150                 155                 160
      Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr
                      165                 170                 175
      Phe Phe Gly Ala Leu Lys Leu Leu
                  180

<210> 44
<211> 133
<212> PRT
<213>  Rattus sp
<400> 44
      Ala Phe Gln Gly Pro Glu Glu Thr Gly Thr Tyr Thr Phe Val Pro Trp
        1               5                  10                  15
      Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys Glu Asn Lys
                   20                  25                  30
      Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu
               35                  40                  45
      Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys
           50                  55                  60
      Ile His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys
       65                  70                  75                  80
      Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala
                       85                  90                  95
      Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro
                  100                 105                 110
      Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly
              115                 120                 125
      Ala Leu Lys Leu Leu
          130

<210> 45
<211> 17
<212> PRT
<213> Homo sapiens
<400> 45
      Met Leu Gln Asn Ser Ala Val Leu Leu Leu Leu Val Ile Ser Ala Ser
        1               5                  10                  15
      Ala

<210> 46
<211> 22
<212> PRT
<213> Artificial Sequence
<220> 
<221> SIGNAL
<222> (1)..(22)
<223> consensus signal sequence
<400> 46
      Met Pro Thr Trp Ala Trp Trp Leu Phe Leu Val Leu Leu Leu Ala Leu
        1               5                  10                  15
      Trp Ala Pro Ala Arg Gly
                   20

<210> 47
<211> 250
<212> PRT
<213> Homo sapiens
<400> 47
      Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly
        1               5                  10                  15
      Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp
                   20                  25                  30
      Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu
               35                  40                  45
      Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg
           50                  55                  60
      Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp
       65                  70                  75                  80
      Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn
                       85                  90                  95
      Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys
                  100                 105                 110
      Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys
              115                 120                 125
      Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg
          130                 135                 140
      Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala
      145                 150                 155                 160
      Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe
                      165                 170                 175
      Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr
                  180                 185                 190
      Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr
              195                 200                 205
      Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile
          210                 215                 220
      Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro
      225                 230                 235                 240
      His Gly Thr Phe Leu Gly Phe Val Lys Leu
                      245                 250

<210> 48
<211> 38
<212> DNA
<213> Artificial Sequence
<220>  
<223> Oligonucleotide primer
<400> 48
      cagactggat ccgccaccat ggatgactcc acagaaag                             38

<210> 49
<211> 33
<212> DNA
<213> Artificial Sequence
<220>  
<223> Oligonucleotide Primer
<400> 49
      cagactggta ccgtcctgcg tgcactacat ggc                                  33

<210> 50
<211> 21
<212> DNA
<213> Artificial Sequence
<220> 
<223> Oligonucleotide Primer
<400> 50
      tggtgtcttt ctaccaggtg g                                               21

<210> 51
<211> 21
<212> DNA
<213> Artificial Sequence
<220>  
<223> Oligonucleotide primer
<400> 51
      tttcttctgg accctgaacg g                                               21

<210> 52
<211> 4458
<212> DNA
<213> Artificial
<220> 
<223> pML124
<400> 52
      gaattcaact tctccatact ttggataagg aaatacagac atgaaaaatc tcattgctga     60
      gttgttattt aagcttgccc aaaaagaaga agagtcgaat gaactgtgtg cgcaggtaga    120
      agctttggag attatcgtca ctgcaatgct tcgcaatatg gcgcaaaatg accaacagcg    180
      gttgattgat caggtagagg gggcgctgta cgaggtaaag cccgatgcca gcattcctga    240
      cgacgatacg gagctgctgc gcgattacgt aaagaagtta ttgaagcatc ctcgtcagta    300
      aaaagttaat cttttcaaca gctgtcataa agttgtcacg gccgagactt atagtcgctt    360
      tgtttttatt ttttaatgta tttgtaacta gtacgcaagt tcacgtaaag gaagtatctc    420
      atatgcagat cttcgtgtaa accggtaccg gcaaaaccat cactctagaa gtggatcctc    480
      tacgccggac gcatcgtggc cggcatcacc ggcgccacag gtgcggttgc tggcgcctat    540
      atcgccgaca tcaccgatgg ggaagatcgg gctcgccact tcgggctcat gagcgcttgt    600
      ttcggcgtgg gtatggtggc aggccccgtg gccgggggac tgttgggcgc catctccttg    660
      catgcaccat tccttgcggc ggcggtgctc aacggcctca acctactact gggctgcttc    720
      ctaatgcagg agtcgcataa gggagagcgt cgaccgatgc ccttgagagc cttcaaccca    780
      gtcagctcct tccggtgggc gcggggcatg actatcgtcg ccgcacttat gactgtcttc    840
      tttatcatgc aactcgtagg acaggtgccg gcagcgctct gggtcatttt cggcgaggac    900
      cgctttcgct ggagcgcgac gatgatcggc ctgtcgcttg cggtattcgg aatcttgcac    960
      gccctcgctc aagccttcgt cactggtccc gccaccaaac gtttcggcga gaagcaggcc   1020
      attatcgccg gcatggcggc cgacgcgctg ggctacgtct tgctggcgtt cgcgacgcga   1080
      ggctggatgg ccttccccat tatgattctt ctcgcttccg gcggcatcgg gatgcccgcg   1140
      ttgcaggcca tgctgtccag gcaggtagat gacgaccatc agggacagct tcaaggatcg   1200
      ctcgcggctc ttaccagcct aacttcgatc actggaccgc tgatcgtcac ggcgatttat   1260
      gccgcctcgg cgagcacatg gaacgggttg gcatggattg taggcgccgc cctatacctt   1320
      gtctgcctcc ccgcgttgcg tcgcggtgca tggagccggg ccacctcgac ctgaatggaa   1380
      gccggcggca cctcgctaac ggattcacca ctccaagaat tggagccaat caattcttgc   1440
      ggagaactgt gaatgcgcaa accaaccctt ggcagaacat atccatcgcg tccgccatct   1500
      ccagcagccg cacgcggcgc atctcgggca gcgttgggtc ctggccacgg gtgcgcatga   1560
      tcgtgctcct gtcgttgagg acccggctag gctggcgggg ttgccttact ggttagcaga   1620
      atgaatcacc gatacgcgag cgaacgtgaa gcgactgctg ctgcaaaacg tctgcgacct   1680
      gagcaacaac atgaatggtc ttcggtttcc gtgtttcgta aagtctggaa acgcggaagt   1740
      cagcgccctg caccattatg ttccggatct gcatcgcagg atgctgctgg ctaccctgtg   1800
      gaacacctac atctgtatta acgaagcgct ggcattgacc ctgagtgatt tttctctggt   1860
      cccgccgcat ccataccgcc agttgtttac cctcacaacg ttccagtaac cgggcatgtt   1920
      catcatcagt aacccgtatc gtgagcatcc tctctcgttt catcggtatc attaccccca   1980
      tgaacagaaa tcccccttac acggaggcat cagtgaccaa acaggaaaaa accgccctta   2040
      acatggcccg ctttatcaga agccagacat taacgcttct ggagaaactc aacgagctgg   2100
      acgcggatga acaggcagac atctgtgaat cgcttcacga ccacgctgat gagctttacc   2160
      gcagctgcct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg   2220
      agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt   2280
      cagcgggtgt tggcgggtgt cggggcgcag ccatgaccca gtcacgtagc gatagcggag   2340
      tgtatactgg cttaactatg cggcatcaga gcagattgta ctgagagtgc accatatatg   2400
      cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct   2460
      tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac   2520
      tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga   2580
      gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat   2640
      aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac   2700
      ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct   2760
      gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg   2820
      ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg   2880
      ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt   2940
      cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg   3000
      attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac   3060
      ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga   3120
      aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt   3180
      gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt   3240
      tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga   3300
      ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc   3360
      taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct   3420
      atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata   3480
      actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca   3540
      cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga   3600
      agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga   3660
      gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctgc aggcatcgtg   3720
      gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga   3780
      gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt   3840
      gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct   3900
      cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca   3960
      ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaac acgggataat   4020
      accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga   4080
      aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc   4140
      aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg   4200
      caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc   4260
      ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt   4320
      gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca   4380
      cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg   4440
      aggccctttc gtcttcaa                                                 4458

<210> 53
<211> 4980
<212> DNA
<213> Artificial Sequence
<220> 
<223> pML124:MBPss-BLyS
<400> 53
      gaattcaact tctccatact ttggataagg aaatacagac atgaaaaatc tcattgctga     60
      gttgttattt aagcttgccc aaaaagaaga agagtcgaat gaactgtgtg cgcaggtaga    120
      agctttggag attatcgtca ctgcaatgct tcgcaatatg gcgcaaaatg accaacagcg    180
      gttgattgat caggtagagg gggcgctgta cgaggtaaag cccgatgcca gcattcctga    240
      cgacgatacg gagctgctgc gcgattacgt aaagaagtta ttgaagcatc ctcgtcagta    300
      aaaagttaat cttttcaaca gctgtcataa agttgtcacg gccgagactt atagtcgctt    360
      tgtttttatt ttttaatgta tttgtaacta gtacgcaagt tcacgtaaag gaagtatctc    420
      atatgaaaat aaaaacaggt gcacgcatcc tcgcattatc cgcattaacg acgatgatgt    480
      tttccgcctc ggctctcgcc gctgttcagg gtccggaaga aaccgttact caggactgcc    540
      ttcagctgat cgcagactct gaaactccga ccatccagaa aggttcttac acctttgttc    600
      cttggctgct ttctttcaaa cgtggttctg ccctggaaga gaaagaaaac aaaatcctgg    660
      ttaaagaaac tggttacttc tttatctacg gtcaggttct ttacactgat aagacctacg    720
      ccatgggtca cctgattcag cgtaagaaag ttcacgtttt cggtgacgag ctgtctctgg    780
      ttactctgtt tcgctgcatt cagaacatgc cggaaactct tcctaacaac tcctgctact    840
      ctgctggcat cgcaaaactg gaagagggtg atgaactgca gctggcaatt cctcgtgaaa    900
      acgcacaaat ttctctggac ggtgatgtaa ccttctttgg tgcactgaaa cttctgtaat    960
      aataaggtac cggcaaaacc atcactctag aagtggatcc tctacgccgg acgcatcgtg   1020
      gccggcatca ccggcgccac aggtgcggtt gctggcgcct atatcgccga catcaccgat   1080
      ggggaagatc gggctcgcca cttcgggctc atgagcgctt gtttcggcgt gggtatggtg   1140
      gcaggccccg tggccggggg actgttgggc gccatctcct tgcatgcacc attccttgcg   1200
      gcggcggtgc tcaacggcct caacctacta ctgggctgct tcctaatgca ggagtcgcat   1260
      aagggagagc gtcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg   1320
      gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta   1380
      ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg   1440
      acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc   1500
      gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg   1560
      gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc   1620
      attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc   1680
      aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc   1740
      ctaacttcga tcactggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca   1800
      tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg   1860
      cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta   1920
      acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc   1980
      aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc   2040
      gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga   2100
      ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg   2160
      agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg   2220
      tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta   2280
      tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat   2340
      taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg   2400
      ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta   2460
      tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt   2520
      acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca   2580
      gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag   2640
      acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt   2700
      tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc   2760
      tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt   2820
      gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta   2880
      tgcggcatca gagcagattg tactgagagt gcaccatata tgcggtgtga aataccgcac   2940
      agatgcgtaa ggagaaaata ccgcatcagg cgctcttccg cttcctcgct cactgactcg   3000
      ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg   3060
      ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag   3120
      gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac   3180
      gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga   3240
      taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt   3300
      accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc   3360
      tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc   3420
      cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta   3480
      agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat   3540
      gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca   3600
      gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct   3660
      tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt   3720
      acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct   3780
      cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc   3840
      acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa   3900
      acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta   3960
      tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc   4020
      ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat   4080
      ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta   4140
      tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt   4200
      aatagtttgc gcaacgttgt tgccattgct gcaggcatcg tggtgtcacg ctcgtcgttt   4260
      ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg   4320
      ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc   4380
      gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc   4440
      gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg   4500
      cggcgaccga gttgctcttg cccggcgtca acacgggata ataccgcgcc acatagcaga   4560
      actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta   4620
      ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct   4680
      tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag   4740
      ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca atattattga   4800
      agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat   4860
      aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc   4920
      attattatca tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtcttcaa   4980

<210> 54
<211> 26
<212> PRT
<213> Artificial Sequence
<220> 
<223> MBP signal sequence
<400> 54
      Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr
      1               5                   10                  15
      Thr Met Met Phe Ser Ala Ser Ala Leu Ala
                  20                  25

<210> 55
<211> 178
<212> PRT
<213> Artificial Sequence
<220> 
<223> MBPss-Neutrokine-alpha
<400> 55
      Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr
      1               5                   10                  15
      Thr Met Met Phe Ser Ala Ser Ala Leu Ala Ala Val Gln Gly Pro Glu
                  20                  25                  30
      Glu Thr Val Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr
              35                  40                  45
      Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser
          50                  55                  60
      Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val
      65                  70                  75                  80
      Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp
                      85                  90                  95
      Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg Lys Lys Val His Val
                  100                 105                 110
      Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn
              115                 120                 125
      Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala
          130                 135                 140
      Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn
      145                 150                 155                 160
      Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys
                      165                 170                 175
      Leu Leu

<210> 56
<211> 21
<212> DNA
<213> Artificial Sequence
<220> 
<223> wild-type Shine Dalgarno box and its adjacent sequence
<400> 56
      tttgtacatg gagaaaataa a                                               21

<210> 57
<211> 21
<212> DNA
<213> Artificial Sequence
<220> 
<223> optimized Shine Dalgarno box and its adjacent sequence
<400> 57
      cacgtaaagg aagtatctca t                                               21

<210> 58
<211> 120
<212> PRT
<213> Mus musculus
<400> 58
      Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
      1               5                   10                  15
      Ser Val Lys Met Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
                  20                  25                  30
      Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
              35                  40                  45
      Gly Tyr Ile Ile Pro Arg Asn Thr Tyr Thr Thr Phe Asn Gln Lys Phe
          50                  55                  60
      Lys Asn Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr
      65                  70                  75                  80
      Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                      85                  90                  95
      Ala Arg His Tyr Gly Gly Gly Tyr Trp Phe Phe Asp Val Trp Gly Ala
                  100                 105                 110
      Gly Thr Thr Val Thr Val Ser Ser
              115                 120

<210> 59
<211> 113
<212> PRT
<213> Mus musculus
<400> 59
      Glu Leu Val Met Thr Gln Thr Pro Ala Ser Leu Ala Val Ser Leu Gly
      1               5                   10                  15
      Gln Arg Ala Thr Ile Ser Cys Arg Gly Ser Glu Ser Val Asp Ser Tyr
                  20                  25                  30
      Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
              35                  40                  45
      Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
          50                  55                  60
      Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Tyr
      65                  70                  75                  80
      Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
                      85                  90                  95
      Asp Asp Pro Met Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
                  100                 105                 110
      Arg

<210> 60
<211> 249
<212> PRT
<213> Homo sapiens

<400> 60
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
  1               5                  10                  15     


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
             20                  25                  30         


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45             


Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Lys Tyr Ser Gln Asn Phe 
     50                  55                  60                 


Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
 65                  70                  75                  80 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95     


Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
    130                 135                 140                 


Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Val 
145                 150                 155                 160 


Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn 
            180                 185                 190         


Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Glu Leu Thr Val Leu Gly 
                245                 

<210> 61
<211> 249
<212> PRT
<213> Homo sapiens

<400> 61
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
  1               5                  10                  15     


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
             20                  25                  30         


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45             


Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Lys Tyr Ser Gln Asn Phe 
     50                  55                  60                 


Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 
 65                  70                  75                  80 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95     


Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ala Leu Ser Pro 
            100                 105                 110         


Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
    130                 135                 140                 


Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Val 
145                 150                 155                 160 


Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn 
            180                 185                 190         


Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ser Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Glu Leu Thr Val Leu Gly 
                245                 