                         SEQUENCE LISTING


<110>  University of North Carolina, Chapel Hill
       Borras, Teresa
       Spiga, Maria-Grazia
 
<120>  GENE THERAPY VECTOR FOR TREATMENT OF STEROID GLAUCOMA

<130>  421-247 PCT

<150>  61/151,654
<151>  2009-02-11

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  2069
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette

<400>  1
ggccgcaata aaatatcttt attttcatta catctgtgtg ttggtttttt gtgtgaatcg       60

atagtactaa catacgctct ccatcaaaac aaaacgaaac aaaacaaact agcaaaatag      120

gctgtcccca gtgcaagtgc aggtgccaga acatttctct atcgataggt accgagctct      180

tacgcgtgct agcggtacat tttgttctag aacaaaatgt accggtacat tttgttctag      240

atctgccgcc ccgactgcat ctgcgtgttc gaattcgcca atgacaagac gctgggcggg      300

gtttgtgtca tcatagaact aaagacatgc aaatatattt cttccgggga caccgccagc      360

aaacgcgagc aacgggccac ggggatgaag cagaagcttc caccatgcac agctttcctc      420

cactgctgct gctgctgttc tggggtgtgg tgtctcacag cttcccagcg actctagaaa      480

cacaagagca agatgtggac ttagtccaga aatacctgga aaaatactac aacctgaaga      540

atgatgggag gcaagttgaa aagcggagaa atagtggccc agtggttgaa aaattgaagc      600

aaatgcagga attctttggg ctgaaagtga ctgggaaacc agatgctgaa accctgaagg      660

tgatgaagca gcccagatgt ggagtgcctg atgtggctca gtttgtcctc actgagggga      720

accctcgctg ggagcaaaca catctgacct acaggattga aaattacacg ccagatttgc      780

caagagcaga tgtggaccat gccattgaga aagccttcca actctggagt aatgtcacac      840

ctctgacatt caccaaggtc tctgagggtc aagcagacat catgatatct tttgtcaggg      900

gagatcatcg ggacaactct ccttttgatg gacctggagg aaatcttgct catgcttttc      960

aaccaggccc aggtattgga ggggatgctc attttgatga agatgaaagg tggaccaaca     1020

atttcagaga gtacaactta catcgtgttg cggctcatga actcggccat tctcttggac     1080

tctcccattc tactgatatc ggggctttga tgtaccctag ctacaccttc agtggtgatg     1140

ttcagctagc tcaggatgac attgatggca tccaagccat atatggacgt tcccaaaatc     1200

ctgtccagcc catcggccca caaaccccaa aagcgtgtga cagtaagcta acctttgatg     1260

ctataactac gattcgggga gaagtgatgt tctttaaaga cagattctac atgcgcacaa     1320

atcccttcta cccggaagtt gagctcaatt tcatttctgt tttctggcca caactgccaa     1380

atgggcttga agctgcttac gaatttgccg acagagatga agtccggttt ttcaaaggga     1440

ataagtactg ggctgttcag ggacagaatg tgctacacgg ataccccaag gacatctaca     1500

gctcctttgg cttccctaga actgtgaagc atatcgatgc tgctctttct gaggaaaaca     1560

ctggaaaaac ctacttcttt gttgctaaca aatactggag gtatgatgaa tataaacgat     1620

ctatggatcc aggttatccc aaaatgatag cacatgactt tcctggaatt ggccacaaag     1680

ttgatgcagt tttcatgaaa gatggatttt tctatttctt tcatggaaca agacaataca     1740

aatttgatcc taaaacgaag agaattttga ctctccagaa agctaatagc tggttcaact     1800

gcaggaaaaa ttgaggccgg ccgcttcgag cagacatgat aagatacatt gatgagtttg     1860

gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta     1920

ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc     1980

attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag taaaacctct     2040

acaaatgtgg taaaatcgat aaggatccg                                       2069


<210>  2
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  2
ggtacatttt gttctagaac aaaatgtacc ggtacatttt gttct                       45


<210>  3
<211>  1410
<212>  DNA
<213>  Homo sapiens

<400>  3
atgcacagct ttcctccact gctgctgctg ctgttctggg gtgtggtgtc tcacagcttc       60

ccagcgactc tagaaacaca agagcaagat gtggacttag tccagaaata cctggaaaaa      120

tactacaacc tgaagaatga tgggaggcaa gttgaaaagc ggagaaatag tggcccagtg      180

gttgaaaaat tgaagcaaat gcaggaattc tttgggctga aagtgactgg gaaaccagat      240

gctgaaaccc tgaaggtgat gaagcagccc agatgtggag tgcctgatgt ggctcagttt      300

gtcctcactg aggggaaccc tcgctgggag caaacacatc tgacctacag gattgaaaat      360

tacacgccag atttgccaag agcagatgtg gaccatgcca ttgagaaagc cttccaactc      420

tggagtaatg tcacacctct gacattcacc aaggtctctg agggtcaagc agacatcatg      480

atatcttttg tcaggggaga tcatcgggac aactctcctt ttgatggacc tggaggaaat      540

cttgctcatg cttttcaacc aggcccaggt attggagggg atgctcattt tgatgaagat      600

gaaaggtgga ccaacaattt cagagagtac aacttacatc gtgttgcggc tcatgaactc      660

ggccattctc ttggactctc ccattctact gatatcgggg ctttgatgta ccctagctac      720

accttcagtg gtgatgttca gctagctcag gatgacattg atggcatcca agccatatat      780

ggacgttccc aaaatcctgt ccagcccatc ggcccacaaa ccccaaaagc gtgtgacagt      840

aagctaacct ttgatgctat aactacgatt cggggagaag tgatgttctt taaagacaga      900

ttctacatgc gcacaaatcc cttctacccg gaagttgagc tcaatttcat ttctgttttc      960

tggccacaac tgccaaatgg gcttgaagct gcttacgaat ttgccgacag agatgaagtc     1020

cggtttttca aagggaataa gtactgggct gttcagggac agaatgtgct acacggatac     1080

cccaaggaca tctacagctc ctttggcttc cctagaactg tgaagcatat cgatgctgct     1140

ctttctgagg aaaacactgg aaaaacctac ttctttgttg ctaacaaata ctggaggtat     1200

gatgaatata aacgatctat ggatccaggt tatcccaaaa tgatagcaca tgactttcct     1260

ggaattggcc acaaagttga tgcagttttc atgaaagatg gatttttcta tttctttcat     1320

ggaacaagac aatacaaatt tgatcctaaa acgaagagaa ttttgactct ccagaaagct     1380

aatagctggt tcaactgcag gaaaaattga                                      1410


<210>  4
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  4

Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 
1               5                   10                  15      


Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 
        35                  40                  45              


Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 
    50                  55                  60                  


Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 
65                  70                  75                  80  


Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 
        115                 120                 125             


Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 
        195                 200                 205             


Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 
225                 230                 235                 240 


Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 
                245                 250                 255     


Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 
            260                 265                 270         


Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 
        275                 280                 285             


Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 
    290                 295                 300                 


Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 
305                 310                 315                 320 


Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 
                325                 330                 335     


Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 
            340                 345                 350         


Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 
        355                 360                 365             


Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 
    370                 375                 380                 


Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 
385                 390                 395                 400 


Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 
                405                 410                 415     


His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 
            420                 425                 430         


Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 
        435                 440                 445             


Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 
    450                 455                 460                 


Asn Cys Arg Lys Asn 
465                 


<210>  5
<211>  1828
<212>  DNA
<213>  Homo sapiens

<400>  5
ctacaaggag gcaggcaaga cagcaaggca tagagacaac atagagctaa gtaaagccag       60

tggaaatgaa gagtcttcca atcctactgt tgctgtgcgt ggcagtttgc tcagcctatc      120

cattggatgg agctgcaagg ggtgaggaca ccagcatgaa ccttgttcag aaatatctag      180

aaaactacta cgacctcaaa aaagatgtga aacagtttgt taggagaaag gacagtggtc      240

ctgttgttaa aaaaatccga gaaatgcaga agttccttgg attggaggtg acggggaagc      300

tggactccga cactctggag gtgatgcgca agcccaggtg tggagttcct gatgttggtc      360

acttcagaac ctttcctggc atcccgaagt ggaggaaaac ccaccttaca tacaggattg      420

tgaattatac accagatttg ccaaaagatg ctgttgattc tgctgttgag aaagctctga      480

aagtctggga agaggtgact ccactcacat tctccaggct gtatgaagga gaggctgata      540

taatgatctc ttttgcagtt agagaacatg gagactttta cccttttgat ggacctggaa      600

atgttttggc ccatgcctat gcccctgggc cagggattaa tggagatgcc cactttgatg      660

atgatgaaca atggacaaag gatacaacag ggaccaattt atttctcgtt gctgctcatg      720

aaattggcca ctccctgggt ctctttcact cagccaacac tgaagctttg atgtacccac      780

tctatcactc actcacagac ctgactcggt tccgcctgtc tcaagatgat ataaatggca      840

ttcagtccct ctatggacct ccccctgact cccctgagac ccccctggta cccacggaac      900

ctgtccctcc agaacctggg acgccagcca actgtgatcc tgctttgtcc tttgatgctg      960

tcagcactct gaggggagaa atcctgatct ttaaagacag gcacttttgg cgcaaatccc     1020

tcaggaagct tgaacctgaa ttgcatttga tctcttcatt ttggccatct cttccttcag     1080

gcgtggatgc cgcatatgaa gttactagca aggacctcgt tttcattttt aaaggaaatc     1140

aattctgggc tatcagagga aatgaggtac gagctggata cccaagaggc atccacaccc     1200

taggtttccc tccaaccgtg aggaaaatcg atgcagccat ttctgataag gaaaagaaca     1260

aaacatattt ctttgtagag gacaaatact ggagatttga tgagaagaga aattccatgg     1320

agccaggctt tcccaagcaa atagctgaag actttccagg gattgactca aagattgatg     1380

ctgtttttga agaatttggg ttcttttatt tctttactgg atcttcacag ttggagtttg     1440

acccaaatgc aaagaaagtg acacacactt tgaagagtaa cagctggctt aattgttgaa     1500

agagatatgt agaaggcaca atatgggcac tttaaatgaa gctaataatt cttcacctaa     1560

gtctctgtga attgaaatgt tcgttttctc ctgcctgtgc tgtgactcga gtcacactca     1620

agggaacttg agcgtgaatc tgtatcttgc cggtcatttt tatgttatta cagggcattc     1680

aaatgggctg ctgcttagct tgcaccttgt cacatagagt gatctttccc aagagaaggg     1740

gaagcactcg tgtgcaacag acaagtgact gtatctgtgt agactatttg cttatttaat     1800

aaagacgatt tgtcagttat tttatctt                                        1828


<210>  6
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Ser Leu Pro Ile Leu Leu Leu Leu Cys Val Ala Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Asp Gly Ala Ala Arg Gly Glu Asp Thr Ser Met Asn 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Asn Tyr Tyr Asp Leu Lys Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Val Arg Arg Lys Asp Ser Gly Pro Val Val Lys Lys Ile 
    50                  55                  60                  


Arg Glu Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp 
65                  70                  75                  80  


Ser Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Gly His Phe Arg Thr Phe Pro Gly Ile Pro Lys Trp Arg Lys Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Lys Asp 
        115                 120                 125             


Ala Val Asp Ser Ala Val Glu Lys Ala Leu Lys Val Trp Glu Glu Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Ala Val Arg Glu His Gly Asp Phe Tyr Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Asn Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Ile Asn 
            180                 185                 190         


Gly Asp Ala His Phe Asp Asp Asp Glu Gln Trp Thr Lys Asp Thr Thr 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Val Ala Ala His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr 
225                 230                 235                 240 


His Ser Leu Thr Asp Leu Thr Arg Phe Arg Leu Ser Gln Asp Asp Ile 
                245                 250                 255     


Asn Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Asp Ser Pro Glu Thr 
            260                 265                 270         


Pro Leu Val Pro Thr Glu Pro Val Pro Pro Glu Pro Gly Thr Pro Ala 
        275                 280                 285             


Asn Cys Asp Pro Ala Leu Ser Phe Asp Ala Val Ser Thr Leu Arg Gly 
    290                 295                 300                 


Glu Ile Leu Ile Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu Arg 
305                 310                 315                 320 


Lys Leu Glu Pro Glu Leu His Leu Ile Ser Ser Phe Trp Pro Ser Leu 
                325                 330                 335     


Pro Ser Gly Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val 
            340                 345                 350         


Phe Ile Phe Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val 
        355                 360                 365             


Arg Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr 
    370                 375                 380                 


Val Arg Lys Ile Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr 
385                 390                 395                 400 


Tyr Phe Phe Val Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn 
                405                 410                 415     


Ser Met Glu Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly 
            420                 425                 430         


Ile Asp Ser Lys Ile Asp Ala Val Phe Glu Glu Phe Gly Phe Phe Tyr 
        435                 440                 445             


Phe Phe Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Lys Lys 
    450                 455                 460                 


Val Thr His Thr Leu Lys Ser Asn Ser Trp Leu Asn Cys 
465                 470                 475         


<210>  7
<211>  1743
<212>  DNA
<213>  Homo sapiens

<400>  7
aaagaaggta agggcagtga gaatgatgca tcttgcattc cttgtgctgt tgtgtctgcc       60

agtctgctct gcctatcctc tgagtggggc agcaaaagag gaggactcca acaaggatct      120

tgcccagcaa tacctagaaa agtactacaa cctcgaaaag gatgtgaaac agtttagaag      180

aaaggacagt aatctcattg ttaaaaaaat ccaaggaatg cagaagttcc ttgggttgga      240

ggtgacaggg aagctagaca ctgacactct ggaggtgatg cgcaagccca ggtgtggagt      300

tcctgacgtt ggtcacttca gctcctttcc tggcatgccg aagtggagga aaacccacct      360

tacatacagg attgtgaatt atacaccaga tttgccaaga gatgctgttg attctgccat      420

tgagaaagct ctgaaagtct gggaagaggt gactccactc acattctcca ggctgtatga      480

aggagaggct gatataatga tctctttcgc agttaaagaa catggagact tttactcttt      540

tgatggccca ggacacagtt tggctcatgc ctacccacct ggacctgggc tttatggaga      600

tattcacttt gatgatgatg aaaaatggac agaagatgca tcaggcacca atttattcct      660

cgttgctgct catgaacttg gccactccct ggggctcttt cactcagcca acactgaagc      720

tttgatgtac ccactctaca actcattcac agagctcgcc cagttccgcc tttcgcaaga      780

tgatgtgaat ggcattcagt ctctctacgg acctccccct gcctctactg aggaacccct      840

ggtgcccaca aaatctgttc cttcgggatc tgagatgcca gccaagtgtg atcctgcttt      900

gtccttcgat gccatcagca ctctgagggg agaatatctg ttctttaaag acagatattt      960

ttggcgaaga tcccactgga accctgaacc tgaatttcat ttgatttctg cattttggcc     1020

ctctcttcca tcatatttgg atgctgcata tgaagttaac agcagggaca ccgtttttat     1080

ttttaaagga aatgagttct gggccatcag aggaaatgag gtacaagcag gttatccaag     1140

aggcatccat accctgggtt ttcctccaac cataaggaaa attgatgcag ctgtttctga     1200

caaggaaaag aagaaaacat acttctttgc agcggacaaa tactggagat ttgatgaaaa     1260

tagccagtcc atggagcaag gcttccctag actaatagct gatgactttc caggagttga     1320

gcctaaggtt gatgctgtat tacaggcatt tggatttttc tacttcttca gtggatcatc     1380

acagtttgag tttgacccca atgccaggat ggtgacacac atattaaaga gtaacagctg     1440

gttacattgc taggcgagat agggggaaga cagatatggg tgtttttaat aaatctaata     1500

attattcatc taatgtatta tgagccaaaa tggttaattt ttcctgcatg ttctgtgact     1560

gaagaagatg agccttgcag atatctgcat gtgtcatgaa gaatgtttct ggaattcttc     1620

acttgctttt gaattgcact gaacagaatt aagaaatact catgtgcaat aggtgagaga     1680

atgtattttc atagatgtgt tattacttcc tcaataaaaa gttttatttt gggcctgttc     1740

ctt                                                                   1743


<210>  8
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Met His Leu Ala Phe Leu Val Leu Leu Cys Leu Pro Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Ser Gly Ala Ala Lys Glu Glu Asp Ser Asn Lys Asp 
            20                  25                  30          


Leu Ala Gln Gln Tyr Leu Glu Lys Tyr Tyr Asn Leu Glu Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Arg Arg Lys Asp Ser Asn Leu Ile Val Lys Lys Ile Gln 
    50                  55                  60                  


Gly Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp Thr 
65                  70                  75                  80  


Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp Val 
                85                  90                  95      


Gly His Phe Ser Ser Phe Pro Gly Met Pro Lys Trp Arg Lys Thr His 
            100                 105                 110         


Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Arg Asp Ala 
        115                 120                 125             


Val Asp Ser Ala Ile Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr 
    130                 135                 140                 


Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile 
145                 150                 155                 160 


Ser Phe Ala Val Lys Glu His Gly Asp Phe Tyr Ser Phe Asp Gly Pro 
                165                 170                 175     


Gly His Ser Leu Ala His Ala Tyr Pro Pro Gly Pro Gly Leu Tyr Gly 
            180                 185                 190         


Asp Ile His Phe Asp Asp Asp Glu Lys Trp Thr Glu Asp Ala Ser Gly 
        195                 200                 205             


Thr Asn Leu Phe Leu Val Ala Ala His Glu Leu Gly His Ser Leu Gly 
    210                 215                 220                 


Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr Asn 
225                 230                 235                 240 


Ser Phe Thr Glu Leu Ala Gln Phe Arg Leu Ser Gln Asp Asp Val Asn 
                245                 250                 255     


Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Ala Ser Thr Glu Glu Pro 
            260                 265                 270         


Leu Val Pro Thr Lys Ser Val Pro Ser Gly Ser Glu Met Pro Ala Lys 
        275                 280                 285             


Cys Asp Pro Ala Leu Ser Phe Asp Ala Ile Ser Thr Leu Arg Gly Glu 
    290                 295                 300                 


Tyr Leu Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg Ser His Trp Asn 
305                 310                 315                 320 


Pro Glu Pro Glu Phe His Leu Ile Ser Ala Phe Trp Pro Ser Leu Pro 
                325                 330                 335     


Ser Tyr Leu Asp Ala Ala Tyr Glu Val Asn Ser Arg Asp Thr Val Phe 
            340                 345                 350         


Ile Phe Lys Gly Asn Glu Phe Trp Ala Ile Arg Gly Asn Glu Val Gln 
        355                 360                 365             


Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr Ile 
    370                 375                 380                 


Arg Lys Ile Asp Ala Ala Val Ser Asp Lys Glu Lys Lys Lys Thr Tyr 
385                 390                 395                 400 


Phe Phe Ala Ala Asp Lys Tyr Trp Arg Phe Asp Glu Asn Ser Gln Ser 
                405                 410                 415     


Met Glu Gln Gly Phe Pro Arg Leu Ile Ala Asp Asp Phe Pro Gly Val 
            420                 425                 430         


Glu Pro Lys Val Asp Ala Val Leu Gln Ala Phe Gly Phe Phe Tyr Phe 
        435                 440                 445             


Phe Ser Gly Ser Ser Gln Phe Glu Phe Asp Pro Asn Ala Arg Met Val 
    450                 455                 460                 


Thr His Ile Leu Lys Ser Asn Ser Trp Leu His Cys 
465                 470                 475     


<210>  9
<211>  1877
<212>  DNA
<213>  Homo sapiens

<400>  9
cagaacccgg actaagggct atataaagag gaacagttca ggaacttagg ctagaaagga       60

acacagtaaa ctgaattgat ccgtttagaa gtttacaatg aagtttcttc taatactgct      120

cctgcaggcc actgcttctg gagctcttcc cctgaacagc tctacaagcc tggaaaaaaa      180

taatgtgcta tttggtgaaa gatacttaga aaaattttat ggccttgaga taaacaaact      240

tccagtgaca aaaatgaaat atagtggaaa cttaatgaag gaaaaaatcc aagaaatgca      300

gcacttcttg ggtctgaaag tgaccgggca actggacaca tctaccctgg agatgatgca      360

cgcacctcga tgtggagtcc ccgatgtcca tcatttcagg gaaatgccag gggggcccgt      420

atggaggaaa cattatatca cctacagaat caataattac acacctgaca tgaaccgtga      480

ggatgttgac tacgcaatcc ggaaagcttt ccaagtatgg agtaatgtta cccccttgaa      540

attcagcaag attaacacag gcatggctga cattttggtg gtttttgccc gtggagctca      600

tggagacttc catgcttttg atggcaaagg tggaatccta gcccatgctt ttggacctgg      660

atctggcatt ggaggggatg cacatttcga tgaggacgaa ttctggacta cacattcagg      720

aggcacaaac ttgttcctca ctgctgttca cgagattggc cattccttag gtcttggcca      780

ttctagtgat ccaaaggccg taatgttccc cacctacaaa tatgttgaca tcaacacatt      840

tcgcctctct gctgatgaca tacgtggcat tcagtccctg tatggagacc caaaagagaa      900

ccaacgcttg ccaaatcctg acaattcaga accagctctc tgtgacccca atttgagttt      960

tgatgctgtc actaccgtgg gaaataagat ctttttcttc aaagacaggt tcttctggct     1020

gaaggtttct gagagaccaa agaccagtgt taatttaatt tcttccttat ggccaacctt     1080

gccatctggc attgaagctg cttatgaaat tgaagccaga aatcaagttt ttctttttaa     1140

agatgacaaa tactggttaa ttagcaattt aagaccagag ccaaattatc ccaagagcat     1200

acattctttt ggttttccta actttgtgaa aaaaattgat gcagctgttt ttaacccacg     1260

tttttatagg acctacttct ttgtagataa ccagtattgg aggtatgatg aaaggagaca     1320

gatgatggac cctggttatc ccaaactgat taccaagaac ttccaaggaa tcgggcctaa     1380

aattgatgca gtcttctact ctaaaaacaa atactactat ttcttccaag gatctaacca     1440

atttgaatat gacttcctac tccaacgtat caccaaaaca ctgaaaagca atagctggtt     1500

tggttgttag aaatggtgta attaatggtt tttgttagtt cacttcagct taataagtat     1560

ttattgcata tttgctatgt cctcagtgta ccactactta gagatatgta tcataaaaat     1620

aaaatctgta aaccataggt aatgattata taaaatacat aatatttttc aattttgaaa     1680

actctaattg tccattcttg cttgactcta ctattaagtt tgaaaatagt taccttcaaa     1740

ggccaagaga attctatttg aagcatgctc tgtaagttgc ttcctaacat ccttggactg     1800

agaaattata cttacttctg gcataactaa aattaagtat atatattttg gctcaaataa     1860

aattgaaaaa aaaatca                                                    1877


<210>  10
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Phe Leu Leu Ile Leu Leu Leu Gln Ala Thr Ala Ser Gly Ala 
1               5                   10                  15      


Leu Pro Leu Asn Ser Ser Thr Ser Leu Glu Lys Asn Asn Val Leu Phe 
            20                  25                  30          


Gly Glu Arg Tyr Leu Glu Lys Phe Tyr Gly Leu Glu Ile Asn Lys Leu 
        35                  40                  45              


Pro Val Thr Lys Met Lys Tyr Ser Gly Asn Leu Met Lys Glu Lys Ile 
    50                  55                  60                  


Gln Glu Met Gln His Phe Leu Gly Leu Lys Val Thr Gly Gln Leu Asp 
65                  70                  75                  80  


Thr Ser Thr Leu Glu Met Met His Ala Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val His His Phe Arg Glu Met Pro Gly Gly Pro Val Trp Arg Lys His 
            100                 105                 110         


Tyr Ile Thr Tyr Arg Ile Asn Asn Tyr Thr Pro Asp Met Asn Arg Glu 
        115                 120                 125             


Asp Val Asp Tyr Ala Ile Arg Lys Ala Phe Gln Val Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Lys Phe Ser Lys Ile Asn Thr Gly Met Ala Asp Ile Leu 
145                 150                 155                 160 


Val Val Phe Ala Arg Gly Ala His Gly Asp Phe His Ala Phe Asp Gly 
                165                 170                 175     


Lys Gly Gly Ile Leu Ala His Ala Phe Gly Pro Gly Ser Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Phe Trp Thr Thr His Ser Gly 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Thr Ala Val His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Gly His Ser Ser Asp Pro Lys Ala Val Met Phe Pro Thr Tyr 
225                 230                 235                 240 


Lys Tyr Val Asp Ile Asn Thr Phe Arg Leu Ser Ala Asp Asp Ile Arg 
                245                 250                 255     


Gly Ile Gln Ser Leu Tyr Gly Asp Pro Lys Glu Asn Gln Arg Leu Pro 
            260                 265                 270         


Asn Pro Asp Asn Ser Glu Pro Ala Leu Cys Asp Pro Asn Leu Ser Phe 
        275                 280                 285             


Asp Ala Val Thr Thr Val Gly Asn Lys Ile Phe Phe Phe Lys Asp Arg 
    290                 295                 300                 


Phe Phe Trp Leu Lys Val Ser Glu Arg Pro Lys Thr Ser Val Asn Leu 
305                 310                 315                 320 


Ile Ser Ser Leu Trp Pro Thr Leu Pro Ser Gly Ile Glu Ala Ala Tyr 
                325                 330                 335     


Glu Ile Glu Ala Arg Asn Gln Val Phe Leu Phe Lys Asp Asp Lys Tyr 
            340                 345                 350         


Trp Leu Ile Ser Asn Leu Arg Pro Glu Pro Asn Tyr Pro Lys Ser Ile 
        355                 360                 365             


His Ser Phe Gly Phe Pro Asn Phe Val Lys Lys Ile Asp Ala Ala Val 
    370                 375                 380                 


Phe Asn Pro Arg Phe Tyr Arg Thr Tyr Phe Phe Val Asp Asn Gln Tyr 
385                 390                 395                 400 


Trp Arg Tyr Asp Glu Arg Arg Gln Met Met Asp Pro Gly Tyr Pro Lys 
                405                 410                 415     


Leu Ile Thr Lys Asn Phe Gln Gly Ile Gly Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Phe Tyr Ser Lys Asn Lys Tyr Tyr Tyr Phe Phe Gln Gly Ser Asn Gln 
        435                 440                 445             


Phe Glu Tyr Asp Phe Leu Leu Gln Arg Ile Thr Lys Thr Leu Lys Ser 
    450                 455                 460                 


Asn Ser Trp Phe Gly Cys 
465                 470 


<210>  11
<211>  3927
<212>  DNA
<213>  Homo sapiens

<400>  11
gcggcggcag gcctagcagc acgggaaccg tcccccgcgc gcatgcgcgc gcccctgaag       60

cgcctggggg acgggtatgg gcgggaggta ggggcgcggc tccgcgtgcc agttgggtgc      120

ccgcgcgtca cgtggtgagg aaggaggcgg aggtctgagt ttcgaaggag ggggggagag      180

aagagggaac gagcaaggga aggaaagcgg ggaaaggagg aaggaaacga acgaggggga      240

gggaggtccc tgttttggag gagctaggag cgttgccggc ccctgaagtg gagcgagagg      300

gaggtgcttc gccgtttctc ctgccagggg aggtcccggc ttcccgtgga ggctccggac      360

caagcccctt cagcttctcc ctccggatcg atgtgctgct gttaacccgt gaggaggcgg      420

cggcggcggc agcggcagcg gaagatggtg ttgctgagag tgttaattct gctcctctcc      480

tgggcggcgg ggatgggagg tcagtatggg aatcctttaa ataaatatat cagacattat      540

gaaggattat cttacaatgt ggattcatta caccaaaaac accagcgtgc caaaagagca      600

gtctcacatg aagaccaatt tttacgtcta gatttccatg cccatggaag acatttcaac      660

ctacgaatga agagggacac ttcccttttc agtgatgaat ttaaagtaga aacatcaaat      720

aaagtacttg attatgatac ctctcatatt tacactggac atatttatgg tgaagaagga      780

agttttagcc atgggtctgt tattgatgga agatttgaag gattcatcca gactcgtggt      840

ggcacatttt atgttgagcc agcagagaga tatattaaag accgaactct gccatttcac      900

tctgtcattt atcatgaaga tgatattaac tatccccata aatacggtcc tcaggggggc      960

tgtgcagatc attcagtatt tgaaagaatg aggaaatacc agatgactgg tgtagaggaa     1020

gtaacacaga tacctcaaga agaacatgct gctaatggtc cagaacttct gaggaaaaaa     1080

cgtacaactt cagctgaaaa aaatacttgt cagctttata ttcagactga tcatttgttc     1140

tttaaatatt acggaacacg agaagctgtg attgcccaga tatccagtca tgttaaagcg     1200

attgatacaa tttaccagac cacagacttc tccggaatcc gtaacatcag tttcatggtg     1260

aaacgcataa gaatcaatac aactgctgat gagaaggacc ctacaaatcc tttccgtttc     1320

ccaaatattg gtgtggagaa gtttctggaa ttgaattctg agcagaatca tgatgactac     1380

tgtttggcct atgtcttcac agaccgagat tttgatgatg gcgtacttgg tctggcttgg     1440

gttggagcac cttcaggaag ctctggagga atatgtgaaa aaagtaaact ctattcagat     1500

ggtaagaaga agtccttaaa cactggaatt attactgttc agaactatgg gtctcatgta     1560

cctcccaaag tctctcacat tacttttgct cacgaagttg gacataactt tggatcccca     1620

catgattctg gaacagagtg cacaccagga gaatctaaga atttgggtca aaaagaaaat     1680

ggcaattaca tcatgtatgc aagagcaaca tctggggaca aacttaacaa caataaattc     1740

tcactctgta gtattagaaa tataagccaa gttcttgaga agaagagaaa caactgtttt     1800

gttgaatctg gccaacctat ttgtggaaat ggaatggtag aacaaggtga agaatgtgat     1860

tgtggctata gtgaccagtg taaagatgaa tgctgcttcg atgcaaatca accagaggga     1920

agaaaatgca aactgaaacc tgggaaacag tgcagtccaa gtcaaggtcc ttgttgtaca     1980

gcacagtgtg cattcaagtc aaagtctgag aagtgtcggg atgattcaga ctgtgcaagg     2040

gaaggaatat gtaatggctt cacagctctc tgcccagcat ctgaccctaa accaaacttc     2100

acagactgta ataggcatac acaagtgtgc attaatgggc aatgtgcagg ttctatctgt     2160

gagaaatatg gcttagagga gtgtacgtgt gccagttctg atggcaaaga tgataaagaa     2220

ttatgccatg tatgctgtat gaagaaaatg gacccatcaa cttgtgccag tacagggtct     2280

gtgcagtgga gtaggcactt cagtggtcga accatcaccc tgcaacctgg atccccttgc     2340

aacgatttta gaggttactg tgatgttttc atgcggtgca gattagtaga tgctgatggt     2400

cctctagcta ggcttaaaaa agcaattttt agtccagagc tctatgaaaa cattgctgaa     2460

tggattgtgg ctcattggtg ggcagtatta cttatgggaa ttgctctgat catgctaatg     2520

gctggattta ttaagatatg cagtgttcat actccaagta gtaatccaaa gttgcctcct     2580

cctaaaccac ttccaggcac tttaaagagg aggagacctc cacagcccat tcagcaaccc     2640

cagcgtcagc ggccccgaga gagttatcaa atgggacaca tgagacgcta actgcagctt     2700

ttgccttggt tcttcctagt gcctacaatg ggaaaacttc actccaaaga gaaacctatt     2760

aagtcatcat ctccaaacta aaccctcaca agtaacagtt gaagaaaaaa tggcaagaga     2820

tcatatcctc agaccaggtg gaattactta aattttaaag cctgaaaatt ccaatttggg     2880

ggtgggaggt ggaaaaggaa cccaattttc ttatgaacag atatttttaa cttaatggca     2940

caaagtctta gaatattatt atgtgccccg tgttccctgt tcttcgttgc tgcattttct     3000

tcacttgcag gcaaacttgg ctctcaataa acttttacca caaattgaaa taaatatatt     3060

tttttcaact gccaatcaag gctaggaggc tcgaccacct caacattgga gacatcactt     3120

gccaatgtac ataccttgtt atatgcagac atgtatttct tacgtacact gtacttctgt     3180

gtgcaattgt aaacagaaat tgcaatatgg atgtttcttt gtattataaa atttttccgc     3240

tcttaattaa aaattactgt ttaattgaca tactcaggat aacagagaat ggtggtattc     3300

agtggtccag gattctgtaa tgctttacac aggcagtttt gaaatgaaaa tcaatttacc     3360

tttctgttac gatggagttg gttttgatac tcattttttc tttatcacat ggctgctacg     3420

ggcacaagtg actatactga agaacacagt taagtgttgt gcaaactgga catagcagca     3480

catactactt cagagttcat gatgtagatg tctggtttct gcttacgtct tttaaacttt     3540

ctaattcaat tccatttttc aattaatagg tgaaatttta ttcatgcttt gatagaaatt     3600

atgtcaatga aatgattctt tttatttgta gcctacttat ttgtgttttt catatatctg     3660

aaatatgcta attatgtttt ctgtctgata tggaaaagaa aagctgtgtc tttatcaaaa     3720

tatttaaacg gttttttcag catatcatca ctgatcattg gtaaccacta aagatgagta     3780

atttgcttaa gtagtagtta aaattgtaga taggccttct gacatttttt ttcctaaaat     3840

ttttaacagc attgaaggtg aaacagcaca atgtcccatt ccaaatttat ttttgaaaca     3900

gatgtaaata attggcattt taaagag                                         3927


<210>  12
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg His Phe Asn Leu Arg Met Lys Arg Asp Thr Ser 
65                  70                  75                  80  


Leu Phe Ser Asp Glu Phe Lys Val Glu Thr Ser Asn Lys Val Leu Asp 
                85                  90                  95      


Tyr Asp Thr Ser His Ile Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly 
            100                 105                 110         


Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe Glu Gly Phe Ile 
        115                 120                 125             


Gln Thr Arg Gly Gly Thr Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile 
    130                 135                 140                 


Lys Asp Arg Thr Leu Pro Phe His Ser Val Ile Tyr His Glu Asp Asp 
145                 150                 155                 160 


Ile Asn Tyr Pro His Lys Tyr Gly Pro Gln Gly Gly Cys Ala Asp His 
                165                 170                 175     


Ser Val Phe Glu Arg Met Arg Lys Tyr Gln Met Thr Gly Val Glu Glu 
            180                 185                 190         


Val Thr Gln Ile Pro Gln Glu Glu His Ala Ala Asn Gly Pro Glu Leu 
        195                 200                 205             


Leu Arg Lys Lys Arg Thr Thr Ser Ala Glu Lys Asn Thr Cys Gln Leu 
    210                 215                 220                 


Tyr Ile Gln Thr Asp His Leu Phe Phe Lys Tyr Tyr Gly Thr Arg Glu 
225                 230                 235                 240 


Ala Val Ile Ala Gln Ile Ser Ser His Val Lys Ala Ile Asp Thr Ile 
                245                 250                 255     


Tyr Gln Thr Thr Asp Phe Ser Gly Ile Arg Asn Ile Ser Phe Met Val 
            260                 265                 270         


Lys Arg Ile Arg Ile Asn Thr Thr Ala Asp Glu Lys Asp Pro Thr Asn 
        275                 280                 285             


Pro Phe Arg Phe Pro Asn Ile Gly Val Glu Lys Phe Leu Glu Leu Asn 
    290                 295                 300                 


Ser Glu Gln Asn His Asp Asp Tyr Cys Leu Ala Tyr Val Phe Thr Asp 
305                 310                 315                 320 


Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val Gly Ala Pro 
                325                 330                 335     


Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu Tyr Ser Asp 
            340                 345                 350         


Gly Lys Lys Lys Ser Leu Asn Thr Gly Ile Ile Thr Val Gln Asn Tyr 
        355                 360                 365             


Gly Ser His Val Pro Pro Lys Val Ser His Ile Thr Phe Ala His Glu 
    370                 375                 380                 


Val Gly His Asn Phe Gly Ser Pro His Asp Ser Gly Thr Glu Cys Thr 
385                 390                 395                 400 


Pro Gly Glu Ser Lys Asn Leu Gly Gln Lys Glu Asn Gly Asn Tyr Ile 
                405                 410                 415     


Met Tyr Ala Arg Ala Thr Ser Gly Asp Lys Leu Asn Asn Asn Lys Phe 
            420                 425                 430         


Ser Leu Cys Ser Ile Arg Asn Ile Ser Gln Val Leu Glu Lys Lys Arg 
        435                 440                 445             


Asn Asn Cys Phe Val Glu Ser Gly Gln Pro Ile Cys Gly Asn Gly Met 
    450                 455                 460                 


Val Glu Gln Gly Glu Glu Cys Asp Cys Gly Tyr Ser Asp Gln Cys Lys 
465                 470                 475                 480 


Asp Glu Cys Cys Phe Asp Ala Asn Gln Pro Glu Gly Arg Lys Cys Lys 
                485                 490                 495     


Leu Lys Pro Gly Lys Gln Cys Ser Pro Ser Gln Gly Pro Cys Cys Thr 
            500                 505                 510         


Ala Gln Cys Ala Phe Lys Ser Lys Ser Glu Lys Cys Arg Asp Asp Ser 
        515                 520                 525             


Asp Cys Ala Arg Glu Gly Ile Cys Asn Gly Phe Thr Ala Leu Cys Pro 
    530                 535                 540                 


Ala Ser Asp Pro Lys Pro Asn Phe Thr Asp Cys Asn Arg His Thr Gln 
545                 550                 555                 560 


Val Cys Ile Asn Gly Gln Cys Ala Gly Ser Ile Cys Glu Lys Tyr Gly 
                565                 570                 575     


Leu Glu Glu Cys Thr Cys Ala Ser Ser Asp Gly Lys Asp Asp Lys Glu 
            580                 585                 590         


Leu Cys His Val Cys Cys Met Lys Lys Met Asp Pro Ser Thr Cys Ala 
        595                 600                 605             


Ser Thr Gly Ser Val Gln Trp Ser Arg His Phe Ser Gly Arg Thr Ile 
    610                 615                 620                 


Thr Leu Gln Pro Gly Ser Pro Cys Asn Asp Phe Arg Gly Tyr Cys Asp 
625                 630                 635                 640 


Val Phe Met Arg Cys Arg Leu Val Asp Ala Asp Gly Pro Leu Ala Arg 
                645                 650                 655     


Leu Lys Lys Ala Ile Phe Ser Pro Glu Leu Tyr Glu Asn Ile Ala Glu 
            660                 665                 670         


Trp Ile Val Ala His Trp Trp Ala Val Leu Leu Met Gly Ile Ala Leu 
        675                 680                 685             


Ile Met Leu Met Ala Gly Phe Ile Lys Ile Cys Ser Val His Thr Pro 
    690                 695                 700                 


Ser Ser Asn Pro Lys Leu Pro Pro Pro Lys Pro Leu Pro Gly Thr Leu 
705                 710                 715                 720 


Lys Arg Arg Arg Pro Pro Gln Pro Ile Gln Gln Pro Gln Arg Gln Arg 
                725                 730                 735     


Pro Arg Glu Ser Tyr Gln Met Gly His Met Arg Arg 
            740                 745             


<210>  13
<211>  6466
<212>  DNA
<213>  Homo sapiens

<400>  13
gccgggcagt gggcaggtat ggctgagggc gtgtgagcgc cgagcgctaa gggccgccgc       60

caccatgcca gggggcgcag gcgccgcccg gctctgcttg ctggcgtttg ccctgcagcc      120

cctccggccg cgggcggcgc gggagcctgg atggacaaga ggaagtgagg aaggcagccc      180

caagctgcag catgaactta tcatacctca gtggaagact tcagaaagcc ccgtgagaga      240

aaagcatcca ctcaaagctg agctcagggt aatggctgag gggcgagaac tgatcctgga      300

cctggagaag aatgagcaac tttttgctcc ttcctacaca gaaacccatt atacttcaag      360

tggtaaccct caaaccacca cacggaaatt ggaggatcac tgcttttacc acggcacggt      420

gagggagaca gaactgtcca gcgtcacgct cagcacttgc cgaggaatta gaggactgat      480

tacggtgagc agcaacctca gctacgtcat cgagcccctc cctgacagca agggccaaca      540

ccttatttac agatctgaac atctcaagcc gcccccggga aactgtgggt tcgagcactc      600

caagcccacc accagggact gggctcttca gtttacacaa cagaccaaga agcgacctcg      660

caggatgaaa agggaagatt taaactccat gaagtatgtg gagctttacc tcgtggctga      720

ttatttagag tttcagaaga atcgacgaga ccaggacgcc accaaacaca agctcataga      780

gatcgccaac tatgttgata agttttaccg atccttgaac atccggattg ctctcgtggg      840

cttggaagtg tggacccacg ggaacatgtg tgaagtttca gagaatccat attctaccct      900

ctggtccttt ctcagttgga ggcgcaagct gcttgcccag aagtaccatg acaacgccca      960

attaatcacg ggcatgtcct tccacggcac caccatcggc ctggcccccc tcatggccat     1020

gtgctctgtg taccagtctg gaggagtcaa catggaccac tccgagaatg ccattggcgt     1080

ggctgccacc atggcccacg agatgggcca caactttggc atgacccatg attctgcaga     1140

ttgctgctcg gccagtgcgg ctgatggtgg gtgcatcatg gcagctgcca ctgggcaccc     1200

ctttcccaaa gtgttcaatg gatgcaacag gagggagctg gacaggtatc tgcagtcagg     1260

tggtggaatg tgtctctcca acatgccaga caccaggatg ttgtatggag gccggaggtg     1320

tgggaacggg tatctggaag atggggaaga gtgtgactgt ggagaagaag aggaatgtaa     1380

caacccctgc tgcaatgcct ctaattgtac cctgaggccg ggggcggagt gtgctcacgg     1440

ctcctgctgc caccagtgta agctgttggc tcctgggacc ctgtgccgcg agcaggccag     1500

gcagtgtgac ctcccggagt tctgtacggg caagtctccc cactgcccta ccaacttcta     1560

ccagatggat ggtaccccct gtgagggcgg ccaggcctac tgctacaacg gcatgtgcct     1620

cacctaccag gagcagtgcc agcagctgtg gggacccgga gcccgacctg cccctgacct     1680

ctgcttcgag aaggtgaatg tggcaggaga cacctttgga aactgtggaa aggacatgaa     1740

tggtgaacac aggaagtgca acatgagaga tgcgaagtgt gggaagatcc agtgtcagag     1800

ctctgaggcc cggcccctgg agtccaacgc ggtgcccatt gacaccacta tcatcatgaa     1860

tgggaggcag atccagtgcc ggggcaccca cgtctaccga ggtcctgagg aggagggtga     1920

catgctggac ccagggctgg tgatgactgg aaccaagtgt ggctacaacc atatttgctt     1980

tgaggggcag tgcaggaaca cctccttctt tgaaactgaa ggctgtggga agaagtgcaa     2040

tggccatggg gtctgtaaca acaaccagaa ctgccactgc ctgccgggct gggccccgcc     2100

cttctgcaac acaccgggcc acgggggcag tatcgacagt gggcctatgc cccctgagag     2160

tgtgggtcct gtggtagctg gagtgttggt ggccatcttg gtgctggcgg tcctcatgct     2220

gatgtactac tgctgcagac agaacaacaa actaggccaa ctcaagccct cagctctccc     2280

ttccaagctg aggcaacagt tcagttgtcc cttcagggtt tctcagaaca gcgggactgg     2340

tcatgccaac ccaactttca agctgcagac gccccagggc aagcgaaagg tgatcaacac     2400

tccggaaatc ctgcggaagc cctcccagcc tcctccccgg ccccctccag attatctgcg     2460

tggtgggtcc ccacctgcac cactgccagc tcacctgagc agggctgcta ggaactcccc     2520

agggcccggg tctcaaatag agaggacgga gtcgtccagg aggcctcctc caagccggcc     2580

aattcccccc gcaccaaatt gcatcgtttc ccaggacttc tccaggcctc ggccgcccca     2640

gaaggcactc ccggcaaacc cagtgccagg ccgcaggagc ctccccaggc caggaggtgc     2700

atccccactg cggccccctg gtgctggccc tcagcagtcc cggcctctgg cagcacttgc     2760

cccaaagttt ccagaataca gatcacagag ggctggaggg atgattagct cgaaaatcta     2820

gacctgtcca aggggcttct ccctttcctt gagctctctg gacactgcag aggacccatg     2880

gccatggaac cctgaagaag catgtctggc cgcctctgag ctcctcccac cctcctccag     2940

gaacctccac atctccaaaa atctccctgt tgactcagtg cctcctcggc ttccttggaa     3000

gcccagaggg actatgatct gatggcctct aggtgttgtt ttgtgcaata tacagcccca     3060

ggtagggagg ggagagtatg aggagggtga ctggcagctt ctcctccaga ctcctagccc     3120

cgaggtgctg atggagatgc tcaaggccag caagcccctc aggccagcac ttcgcttgca     3180

gaagccatcc attcactcct ggggtgcagg gcacgcaaga gagcttccca ttgcttctgc     3240

tctcctcaga ggtcccgggc tggatggagg ctggtactta cccacccctt ttagctttta     3300

gggattaagg aagggtcaag ccagccactg ctgtggccct gcccagggct tggttgaggg     3360

aacggcttct ggctgtatgg ctgcatgtga caagccacgt cccctcccac ctctccccaa     3420

acccctgcat ccctgtattc acacgggtca ctctgactca gacaggtact attcgtaggc     3480

agtgtagaca gcaggaggag caccgggctt gggcttcctc tgagccgtga tgccaaaggt     3540

tgcgactcct gactctggat aatttttagt tgctctttgt tttctctgcc gcactttcct     3600

ggtgccccac gcttttctct cttccttccc ctctcattct ccctctaatg tgtggtgctt     3660

tggtgagcaa accctcagca gtcctgacct tcgggtgacc aggtgcttgt gacctacaag     3720

tcagagtcct ctctcacagt cggccactgg atttccctca ctggctctca ggagtgtgac     3780

cagagtagac ttggggcatg gccattgggg tcatatgttt atttttcatt gtgttttgtg     3840

acctcagcag ggtgggggtc ttcctcctta ctctaagcta aatctaggtg aggtttcccc     3900

ttagggagcc cagctattta caaagtacac acgagggagc aggctggtca ttgacttcgg     3960

gctggaccgt tgccctctga gcagagaaca gacccatttc tgggagctgc ccgagatcac     4020

tggagaaggc agccagcagc agctgcactg gaacagtcag agcagggagc ctcttcctca     4080

acccagcttt ttgtcattca cttccttttg ttctctctct ggtcactgcc cttacctgac     4140

cctcacagaa agagagctct gagcaggtga gggggtctgc ggtggctcct gtcttccctg     4200

cagcagggaa ggagggccgt gtggtgcttt gctagatagg acggtttttg caaagcacct     4260

ggagatgttt gctgggagat agactcccac tccacaaagg tgctgggtgg ctctccggac     4320

aggagctggc ctgactctca ctcctctgag gctttcctgg ggcctcctcc catcctgcca     4380

tgagcaattg tttgctcttg aaaacctcac tgcaaggctg aggctgagct tctgattcac     4440

caccccaggg cctccttata gttctctgca cacaataggt gcttcttgga tgttcttggg     4500

tttggaaata agtggaaaat acgggatgta cccctggggg aaaagcctgg gttgggttta     4560

gaaagatctc aggaaaatga gtttctcttc cctcagggtg gctgtgatac aggttcccca     4620

tgtccttgcc gtgggtcatc cttgctgtgg gtcatccttg ctgtggagat ccattcccca     4680

cctttcctgt ggcccaacct tttatttaaa tgtgctaccc tctgcctcaa ggcttggttc     4740

ctggaaagta aaggtgaaaa catccccttt cacccctctg caaaacaaac aagcaacatc     4800

ctcaaaaccc aaccccatgc ctcacagagc ttcctgtggc ttctccagcc tttctccctc     4860

acatcaggag gtagatagct ctgaaatgac agcgccacag ccatagtgac tgcatgagcc     4920

atctgaacct gcagtccacc ctccctggaa ccacaccaga aagagacctg ggttgtcgtt     4980

ttcttgcttt ttgttttgtt ttgttttatt attttcatat cacctccatc ccataaagtt     5040

gtactgtgaa ctggaagatg gtggaatgtt ttggaatttg atagactttc ggcaaccagt     5100

tctactaatg cttcactcct ggctctgttc agggaggctg cccaggagga agactggcca     5160

ttatgcatcc ccttttcttt ccagtgccca gtatgctgtt ttgaggtgtc aaatacaaat     5220

aaatctgggc ttagggaagg agagacctta ttccaaagca cgattgcaga aggggaaagg     5280

gaatattgca aaagggagag gaaggggcct tatgggaata gtgaaaaggc tcagaccgac     5340

cgatggcaag atctgcaagc gtctcaaagc ccaggcagaa aaggactttt cttttattgg     5400

aagaagtaaa catggctaga aagaaccacg ttcagggaat gacgttgtgc ccagcctttt     5460

tttttttttt tttttttttg tctccagggg aggggctgtt tgctggctca ggctgaggat     5520

ggcccaaagt ccagggtctg gtggggagga gggaagctta actcaagttt gggttagtga     5580

gttagcaagc tctttgtgca gatggggatg taggtaaatc tttttaaaag tgaaattaac     5640

ctcctgccaa ttttacaacc caagaatttt tttttaaggg ccttggagcc atctctaaaa     5700

caaacctcaa gggatttagt gccctgtctc cctgtctcta gaagccttag cctgggcacc     5760

tggctcaatc ttgtaactgc ctgctagcca tagattcctt tcagccttgc tgacttctcc     5820

ctataaaagt aaagcctttt tctgccccag ctctgagaca cttgcagatc ttaaggtctg     5880

agacttgctg attttctggt tggagtgttt ttttgtattg ccatagtccc ttccccctga     5940

agcaatagcc cctccccacc tcctgcaata cgcctttcca atctttattg gaagtctctc     6000

cctgcctact tcctaattta ttcttatttg acagagggta tggaagactt gcaatttgaa     6060

aactggggac cagttccaaa gtcagtaatt gtgttaacca cgtgtataac agctctgctg     6120

gacacccaag aaagccatgg gaacgccaac tggaaaggtc cccttcccca ggggagcctg     6180

cgaaggagag gttctgtaga atccaagccc acatttccaa agtcaccccc aacgcgtcct     6240

ctcacaccgt ccactgtgcg tttgtatgtg tctgggatcc agggcaatgt gaattttctt     6300

tttatttggg agattgttca cggaaaacag atcttcttct ctcttgtcca cctattaatt     6360

gtttacaata tttgtacatc tatgcaaaat acttgaatgg gccatggtgc cttttttcct     6420

tgttagtatt taattaaaaa tgaattgttt gtcatttgca atgtta                    6466


<210>  14
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala 
1               5                   10                  15      


Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Arg 
            20                  25                  30          


Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile Pro 
        35                  40                  45              


Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu Lys 
    50                  55                  60                  


Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp Leu 
65                  70                  75                  80  


Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His Tyr 
                85                  90                  95      


Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp His 
            100                 105                 110         


Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val Thr 
        115                 120                 125             


Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser Asn 
    130                 135                 140                 


Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His Leu 
145                 150                 155                 160 


Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly Phe 
                165                 170                 175     


Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr Gln 
            180                 185                 190         


Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn Ser 
        195                 200                 205             


Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe Gln 
    210                 215                 220                 


Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu Ile 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile Ala 
                245                 250                 255     


Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val Ser 
            260                 265                 270         


Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg Lys 
        275                 280                 285             


Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly Met 
    290                 295                 300                 


Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met Cys 
305                 310                 315                 320 


Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn Ala 
                325                 330                 335     


Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe Gly 
            340                 345                 350         


Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp Gly 
        355                 360                 365             


Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val Phe 
    370                 375                 380                 


Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly Gly 
385                 390                 395                 400 


Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly Gly 
                405                 410                 415     


Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp Cys 
            420                 425                 430         


Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn Cys 
        435                 440                 445             


Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His Gln 
    450                 455                 460                 


Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg Gln 
465                 470                 475                 480 


Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro Thr 
                485                 490                 495     


Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala Tyr 
            500                 505                 510         


Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln Leu 
        515                 520                 525             


Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys Val 
    530                 535                 540                 


Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn Gly 
545                 550                 555                 560 


Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile Gln 
                565                 570                 575     


Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro Ile 
            580                 585                 590         


Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly Thr 
        595                 600                 605             


His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro Gly 
    610                 615                 620                 


Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe Glu 
625                 630                 635                 640 


Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly Lys 
                645                 650                 655     


Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His Cys 
            660                 665                 670         


Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly Gly 
        675                 680                 685             


Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val Val 
    690                 695                 700                 


Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu Met 
705                 710                 715                 720 


Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro Ser 
                725                 730                 735     


Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg Val 
            740                 745                 750         


Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu Gln 
        755                 760                 765             


Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu Arg 
    770                 775                 780                 


Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg Gly 
785                 790                 795                 800 


Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala Arg 
                805                 810                 815     


Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser Arg 
            820                 825                 830         


Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile Val 
        835                 840                 845             


Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro Ala 
    850                 855                 860                 


Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala Ser 
865                 870                 875                 880 


Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu Ala 
                885                 890                 895     


Ala Leu Ala Pro Lys Phe Pro Glu Tyr Arg Ser Gln Arg Ala Gly Gly 
            900                 905                 910         


Met Ile Ser Ser Lys Ile 
        915             


<210>  15
<211>  3220
<212>  DNA
<213>  Homo sapiens

<400>  15
tcactggaga ggaggcaggg acagacccag cagcacccac ctgagcgaga agagcagaca       60

ccgtgctcct ggaatcaccc agcatgttgc aaggtctcct gccagtcagt ctcctcctct      120

ctgttgcagt aagtgctata aaagaactcc ctggggtgaa gaagtatgaa gtggtttatc      180

ctataagact tcatccactg cataaaagag aggccaaaga gccagagcaa caggaacaat      240

ttgaaactga attaaagtat aaaatgacaa ttaatggaaa aattgcagtg ctttatttga      300

aaaaaaacaa gaacctcctt gcaccaggct acacggaaac atattataat tccactggaa      360

aggagatcac cacaagccca caaattatgg atgattgtta ttatcaagga catattctta      420

atgaaaaggt ttctgacgct agcatcagca catgtagggg tctaaggggc tacttcagtc      480

agggggatca aagatacttt attgaacctt taagccccat acatcgggat ggacaggagc      540

atgcactctt caagtataac cctgatgaaa agaattatga cagcacctgt gggatggatg      600

gtgtgttgtg ggcccacgat ttgcagcaga acattgccct acctgccacc aaactagtaa      660

aattgaaaga caggaaggtt caggaacatg agaaatacat agaatattat ttggtcctgg      720

ataatggtga gtttaaaagg tacaatgaga atcaagatga gatcagaaag agggtatttg      780

agatggctaa ttatgtcaac atgctttata aaaagctcaa tactcatgtg gccttagttg      840

gtatggaaat ctggactgac aaggataaga taaagataac cccaaatgca agcttcacct      900

tggagaattt ttctaaatgg agggggagtg ttctctcaag aagaaagcgt catgatattg      960

ctcagttaat cacagcaaca gaacttgctg gaacgactgt gggtcttgca tttatgtcta     1020

caatgtgttc tccttattct gttggcgttg ttcaggacca cagcgataat cttcttagag     1080

ttgcagggac aatggcacat gaaatgggcc acaactttgg aatgtttcat gacgactatt     1140

cttgcaagtg tccttctaca atatgtgtga tggacaaagc actgagcttc tatataccca     1200

cagacttcag ttcctgcagc cgtctcagct atgacaagtt ttttgaagat aaattatcaa     1260

attgcctctt taatgctcca ttgcctacag atatcatatc cactccaatt tgtgggaacc     1320

agttggtgga aatgggagag gactgtgatt gtgggacatc tgaggaatgt accaatattt     1380

gctgtgatgc taagacatgt aaaatcaaag caacttttca atgtgcatta ggagaatgtt     1440

gtgaaaaatg ccaatttaaa aaggctggga tggtgtgcag accagcaaaa gatgagtgcg     1500

acctgcctga aatgtgtaat ggtaaatctg gtaattgtcc tgatgataga ttccaagtca     1560

atggcttccc ttgccatcac gggaagggcc actgcttgat ggggacatgc cccacactgc     1620

aggagcagtg cacagagctg tggggaccag gaactgaggt tgcagataag tcatgttaca     1680

acaggaatga aggtgggtca aagtacgggt actgtcgcag agtggatgac acactcattc     1740

cctgcaaagc aaatgatacc atgtgtggga agttgttctg tcaaggtggg tcggataatt     1800

tgccctggaa aggacggata gtgactttcc tgacatgtaa aacatttgat cctgaagaca     1860

caagtcaaga aataggcatg gtggccaatg gaactaagtg tggcgataac aaggtttgca     1920

ttaatgcaga atgtgtggat attgagaaag cctacaaatc aaccaattgc tcatctaagt     1980

gcaaaggaca tgctgtgtgt gaccatgagc tccagtgtca atgtgaggaa ggatggatcc     2040

ctcccgactg cgatgactcc tcagtggtct tccacttctc cattgtggtt ggggtgctgt     2100

tcccaatggc ggtcattttt gtggtggttg ctatggtaat ccggcaccag agctccagag     2160

aaaagcagaa gaaagatcag aggccactat ctaccactgg caccaggcca cacaaacaga     2220

agaggaaacc ccagatggta aaggctgttc aaccccaaga gatgagtcag atgaagcccc     2280

atgtgtatga tctgccagta gaaggcaatg agcccccagc ctcttttcat aaagacacaa     2340

acgcacttcc ccctactgtt ttcaaggata atccagtgtc tacacctaag gactcaaatc     2400

caaaagcatg aagcaacagc taagcaagaa ctaatggcta aattatcaac ttggaaaact     2460

ggaaaatctg gatggcagag aaatatacta tctatctcac cagtatttgc tctcgactca     2520

agaaggttaa cattttctga ttcatgttag actttgaaga gactaaagaa aattttcaag     2580

aggaacatat gcctgagaac ctttgcatga atttaaaatt tcaattatcc attcttataa     2640

gaaggaagat gattgtaaag aaatatctcc gaagttaaaa tctgtaatag gaattgattc     2700

attctctaat gaaaacaaaa cataaaaaca tcacactaat cttggaggaa taagaaaaat     2760

tgtacatcca ttaaatgtac aattgattgc aacatcttga ttgttttaac cattaacttg     2820

tcaaattaca atcacagtta agaaaatgat gtaaaattct gttttgtgga tctctttcct     2880

agattagctt ctgaaatcat tattagctat atcatttgag gttttctaca atttggtata     2940

actaagaatt taaaaatgtt ttatcatata tatttgtata attaattact ggcatggtta     3000

aagtggtttt cactttttaa atggagaaaa tttcagttaa attaatagga taaaccaggt     3060

tgcgaactgg tgacctgtag gccatgtttg cactgcaaat atatttggtc tgaatgatat     3120

tgatattgga cacatagtac ttttacatgt tttgaatgta ttgctaatat ttaaaaattg     3180

agagatcttg cataaacaat agattcccag ctttgtcaga                           3220


<210>  16
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Leu Gln Gly Leu Leu Pro Val Ser Leu Leu Leu Ser Val Ala Val 
1               5                   10                  15      


Ser Ala Ile Lys Glu Leu Pro Gly Val Lys Lys Tyr Glu Val Val Tyr 
            20                  25                  30          


Pro Ile Arg Leu His Pro Leu His Lys Arg Glu Ala Lys Glu Pro Glu 
        35                  40                  45              


Gln Gln Glu Gln Phe Glu Thr Glu Leu Lys Tyr Lys Met Thr Ile Asn 
    50                  55                  60                  


Gly Lys Ile Ala Val Leu Tyr Leu Lys Lys Asn Lys Asn Leu Leu Ala 
65                  70                  75                  80  


Pro Gly Tyr Thr Glu Thr Tyr Tyr Asn Ser Thr Gly Lys Glu Ile Thr 
                85                  90                  95      


Thr Ser Pro Gln Ile Met Asp Asp Cys Tyr Tyr Gln Gly His Ile Leu 
            100                 105                 110         


Asn Glu Lys Val Ser Asp Ala Ser Ile Ser Thr Cys Arg Gly Leu Arg 
        115                 120                 125             


Gly Tyr Phe Ser Gln Gly Asp Gln Arg Tyr Phe Ile Glu Pro Leu Ser 
    130                 135                 140                 


Pro Ile His Arg Asp Gly Gln Glu His Ala Leu Phe Lys Tyr Asn Pro 
145                 150                 155                 160 


Asp Glu Lys Asn Tyr Asp Ser Thr Cys Gly Met Asp Gly Val Leu Trp 
                165                 170                 175     


Ala His Asp Leu Gln Gln Asn Ile Ala Leu Pro Ala Thr Lys Leu Val 
            180                 185                 190         


Lys Leu Lys Asp Arg Lys Val Gln Glu His Glu Lys Tyr Ile Glu Tyr 
        195                 200                 205             


Tyr Leu Val Leu Asp Asn Gly Glu Phe Lys Arg Tyr Asn Glu Asn Gln 
    210                 215                 220                 


Asp Glu Ile Arg Lys Arg Val Phe Glu Met Ala Asn Tyr Val Asn Met 
225                 230                 235                 240 


Leu Tyr Lys Lys Leu Asn Thr His Val Ala Leu Val Gly Met Glu Ile 
                245                 250                 255     


Trp Thr Asp Lys Asp Lys Ile Lys Ile Thr Pro Asn Ala Ser Phe Thr 
            260                 265                 270         


Leu Glu Asn Phe Ser Lys Trp Arg Gly Ser Val Leu Ser Arg Arg Lys 
        275                 280                 285             


Arg His Asp Ile Ala Gln Leu Ile Thr Ala Thr Glu Leu Ala Gly Thr 
    290                 295                 300                 


Thr Val Gly Leu Ala Phe Met Ser Thr Met Cys Ser Pro Tyr Ser Val 
305                 310                 315                 320 


Gly Val Val Gln Asp His Ser Asp Asn Leu Leu Arg Val Ala Gly Thr 
                325                 330                 335     


Met Ala His Glu Met Gly His Asn Phe Gly Met Phe His Asp Asp Tyr 
            340                 345                 350         


Ser Cys Lys Cys Pro Ser Thr Ile Cys Val Met Asp Lys Ala Leu Ser 
        355                 360                 365             


Phe Tyr Ile Pro Thr Asp Phe Ser Ser Cys Ser Arg Leu Ser Tyr Asp 
    370                 375                 380                 


Lys Phe Phe Glu Asp Lys Leu Ser Asn Cys Leu Phe Asn Ala Pro Leu 
385                 390                 395                 400 


Pro Thr Asp Ile Ile Ser Thr Pro Ile Cys Gly Asn Gln Leu Val Glu 
                405                 410                 415     


Met Gly Glu Asp Cys Asp Cys Gly Thr Ser Glu Glu Cys Thr Asn Ile 
            420                 425                 430         


Cys Cys Asp Ala Lys Thr Cys Lys Ile Lys Ala Thr Phe Gln Cys Ala 
        435                 440                 445             


Leu Gly Glu Cys Cys Glu Lys Cys Gln Phe Lys Lys Ala Gly Met Val 
    450                 455                 460                 


Cys Arg Pro Ala Lys Asp Glu Cys Asp Leu Pro Glu Met Cys Asn Gly 
465                 470                 475                 480 


Lys Ser Gly Asn Cys Pro Asp Asp Arg Phe Gln Val Asn Gly Phe Pro 
                485                 490                 495     


Cys His His Gly Lys Gly His Cys Leu Met Gly Thr Cys Pro Thr Leu 
            500                 505                 510         


Gln Glu Gln Cys Thr Glu Leu Trp Gly Pro Gly Thr Glu Val Ala Asp 
        515                 520                 525             


Lys Ser Cys Tyr Asn Arg Asn Glu Gly Gly Ser Lys Tyr Gly Tyr Cys 
    530                 535                 540                 


Arg Arg Val Asp Asp Thr Leu Ile Pro Cys Lys Ala Asn Asp Thr Met 
545                 550                 555                 560 


Cys Gly Lys Leu Phe Cys Gln Gly Gly Ser Asp Asn Leu Pro Trp Lys 
                565                 570                 575     


Gly Arg Ile Val Thr Phe Leu Thr Cys Lys Thr Phe Asp Pro Glu Asp 
            580                 585                 590         


Thr Ser Gln Glu Ile Gly Met Val Ala Asn Gly Thr Lys Cys Gly Asp 
        595                 600                 605             


Asn Lys Val Cys Ile Asn Ala Glu Cys Val Asp Ile Glu Lys Ala Tyr 
    610                 615                 620                 


Lys Ser Thr Asn Cys Ser Ser Lys Cys Lys Gly His Ala Val Cys Asp 
625                 630                 635                 640 


His Glu Leu Gln Cys Gln Cys Glu Glu Gly Trp Ile Pro Pro Asp Cys 
                645                 650                 655     


Asp Asp Ser Ser Val Val Phe His Phe Ser Ile Val Val Gly Val Leu 
            660                 665                 670         


Phe Pro Met Ala Val Ile Phe Val Val Val Ala Met Val Ile Arg His 
        675                 680                 685             


Gln Ser Ser Arg Glu Lys Gln Lys Lys Asp Gln Arg Pro Leu Ser Thr 
    690                 695                 700                 


Thr Gly Thr Arg Pro His Lys Gln Lys Arg Lys Pro Gln Met Val Lys 
705                 710                 715                 720 


Ala Val Gln Pro Gln Glu Met Ser Gln Met Lys Pro His Val Tyr Asp 
                725                 730                 735     


Leu Pro Val Glu Gly Asn Glu Pro Pro Ala Ser Phe His Lys Asp Thr 
            740                 745                 750         


Asn Ala Leu Pro Pro Thr Val Phe Lys Asp Asn Pro Val Ser Thr Pro 
        755                 760                 765             


Lys Asp Ser Asn Pro Lys Ala 
    770                 775 


<210>  17
<211>  4670
<212>  DNA
<213>  Homo sapiens

<400>  17
gcactcgctg gaaagcggct ccgagccagg ggctattgca aagccagggt gcgctaccgg       60

acggagaggg gagagccctg agcagagtga gcaacatcgc agccaaggcg gaggccgaag      120

aggggcgcca ggcaccaatc tccgcgttgc ctcagccccg gaggcgcccc agagcgcttc      180

ttgtcccagc agagccactc tgcctgcgcc tgcctctcag tgtctccaac tttgcgctgg      240

aagaaaaact tcccgcgcgc cggcagaact gcagcgcctc cttttagtga ctccgggagc      300

ttcggctgta gccggctctg cgcgcccttc caacgaataa tagaaattgt taattttaac      360

aatccagagc aggccaacga ggctttgctc tcccgacccg aactaaaggt ccctcgctcc      420

gtgcgctgct acgagcggtg tctcctgggg ctccaatgca gcgagctgtg cccgaggggt      480

tcggaaggcg caagctgggc agcgacatgg ggaacgcgga gcgggctccg gggtctcgga      540

gctttgggcc cgtacccacg ctgctgctgc tcgccgcggc gctactggcc gtgtcggacg      600

cactcgggcg cccctccgag gaggacgagg agctagtggt gccggagctg gagcgcgccc      660

cgggacacgg gaccacgcgc ctccgcctgc acgcctttga ccagcagctg gatctggagc      720

tgcggcccga cagcagcttt ttggcgcccg gcttcacgct ccagaacgtg gggcgcaaat      780

ccgggtccga gacgccgctt ccggaaaccg acctggcgca ctgcttctac tccggcaccg      840

tgaatggcga tcccagctcg gctgccgccc tcagcctctg cgagggcgtg cgcggcgcct      900

tctacctgct gggggaggcg tatttcatcc agccgctgcc cgccgccagc gagcgcctcg      960

ccaccgccgc cccaggggag aagccgccgg caccactaca gttccacctc ctgcggcgga     1020

atcggcaggg cgacgtcggc ggcacgtgcg gggtcgtgga cgacgagccc cggccgactg     1080

ggaaagcgga gaccgaagac gaggacgaag ggactgaggg cgaggacgaa ggggctcagt     1140

ggtcgccgca ggacccggca ctgcaaggcg taggacagcc cacaggaact ggaagcataa     1200

gaaagaagcg atttgtgtcc agtcaccgct atgtggaaac catgcttgtg gcagaccagt     1260

cgatggcaga attccacggc agtggtctaa agcattacct tctcacgttg ttttcggtgg     1320

cagccagatt gtacaaacac cccagcattc gtaattcagt tagcctggtg gtggtgaaga     1380

tcttggtcat ccacgatgaa cagaaggggc cggaagtgac ctccaatgct gccctcactc     1440

tgcggaactt ttgcaactgg cagaagcagc acaacccacc cagtgaccgg gatgcagagc     1500

actatgacac agcaattctt ttcaccagac aggacttgtg tgggtcccag acatgtgata     1560

ctcttgggat ggctgatgtt ggaactgtgt gtgatccgag cagaagctgc tccgtcatag     1620

aagatgatgg tttacaagct gccttcacca cagcccatga attaggccac gtgtttaaca     1680

tgccacatga tgatgcaaag cagtgtgcca gccttaatgg tgtgaaccag gattcccaca     1740

tgatggcgtc aatgctttcc aacctggacc acagccagcc ttggtctcct tgcagtgcct     1800

acatgattac atcatttctg gataatggtc atggggaatg tttgatggac aagcctcaga     1860

atcccataca gctcccaggc gatctccctg gcacctcgta cgatgccaac cggcagtgcc     1920

agtttacatt tggggaggac tccaaacact gccccgatgc agccagcaca tgtagcacct     1980

tgtggtgtac cggcacctct ggtggggtgc tggtgtgtca aaccaaacac ttcccgtggg     2040

cggatggcac cagctgtgga gaagggaaat ggtgtatcaa cggcaagtgt gtgaacaaaa     2100

ccgacagaaa gcattttgat acgccttttc atggaagctg gggaatgtgg gggccttggg     2160

gagactgttc gagaacgtgc ggtggaggag tccagtacac gatgagggaa tgtgacaacc     2220

cagtcccaaa gaatggaggg aagtactgtg aaggcaaacg agtgcgctac agatcctgta     2280

accttgagga ctgtccagac aataatggaa aaacctttag agaggaacaa tgtgaagcac     2340

acaacgagtt ttcaaaagct tcctttggga gtgggcctgc ggtggaatgg attcccaagt     2400

acgctggcgt ctcaccaaag gacaggtgca agctcatctg ccaagccaaa ggcattggct     2460

acttcttcgt tttgcagccc aaggttgtag atggtactcc atgtagccca gattccacct     2520

ctgtctgtgt gcaaggacag tgtgtaaaag ctggttgtga tcgcatcata gactccaaaa     2580

agaagtttga taaatgtggt gtttgcgggg gaaatggatc tacttgtaaa aaaatatcag     2640

gatcagttac tagtgcaaaa cctggatatc atgatatcat cacaattcca actggagcca     2700

ccaacatcga agtgaaacag cggaaccaga ggggatccag gaacaatggc agctttcttg     2760

ccatcaaagc tgctgatggc acatatattc ttaatggtga ctacactttg tccaccttag     2820

agcaagacat tatgtacaaa ggtgttgtct tgaggtacag cggctcctct gcggcattgg     2880

aaagaattcg cagctttagc cctctcaaag agcccttgac catccaggtt cttactgtgg     2940

gcaatgccct tcgacctaaa attaaataca cctacttcgt aaagaagaag aaggaatctt     3000

tcaatgctat ccccactttt tcagcatggg tcattgaaga gtggggcgaa tgttctaagt     3060

catgtgaatt gggttggcag agaagactgg tagaatgccg agacattaat ggacagcctg     3120

cttccgagtg tgcaaaggaa gtgaagccag ccagcaccag accttgtgca gaccatccct     3180

gcccccagtg gcagctgggg gagtggtcat catgttctaa gacctgtggg aagggttaca     3240

aaaaaagaag cttgaagtgt ctgtcccatg atggaggggt gttatctcat gagagctgtg     3300

atcctttaaa gaaacctaaa catttcatag acttttgcac aatggcagaa tgcagttaag     3360

tggtttaagt ggtgttagct ttgagggcaa ggcaaagtga ggaagggctg gtgcagggaa     3420

agcaagaagg ctggagggat ccagcgtatc ttgccagtaa ccagtgaggt gtatcagtaa     3480

ggtgggatta tgggggtaga tagaaaagga gttgaatcat cagagtaaac tgccagttgc     3540

aaatttgata ggatagttag tgaggattat taacctctga gcagtgatat agcataataa     3600

agccccgggc attattatta ttatttcttt tgttacatct attacaagtt tagaaaaaac     3660

aaagcaattg tcaaaaaaag ttagaactat tacaacccct gtttcctggt acttatcaaa     3720

tacttagtat catgggggtt gggaaatgaa aagtaggaga aaagtgagat tttactaaga     3780

cctgttttac tttacctcac taacaatggg gggagaaagg agtacaaata ggatctttga     3840

ccagcactgt ttatggctgc tatggtttca gagaatgttt atacattatt tctaccgaga     3900

attaaaactt cagattgttc aacatgagag aaaggctcag caacgtgaaa taacgcaaat     3960

ggcttcctct ttcctttttt ggaccatctc agtctttatt tgtgtaattc attttgagga     4020

aaaaacaact ccatgtattt attcaagtgc attaaagtct acaatggaaa aaaagcagtg     4080

aagcattaga tgctggtaaa agctagagga gacacaatga gcttagtacc tccaacttcc     4140

tttctttcct accatgtaac cctgctttgg gaatatggat gtaaagaagt aacttgtgtc     4200

tcatgaaaat cagtacaatc acacaaggag gatgaaacgc cggaacaaaa atgaggtgtg     4260

tagaacaggg tcccacaggt ttggggacat tgagatcact tgtcttgtgg tggggaggct     4320

gctgaggggt agcaggtcca tctccagcag ctggtccaac agtcgtatcc tggtgaatgt     4380

ctgttcagct cttctgtgag aatatgattt tttccatatg tatatagtaa aatatgttac     4440

tataaattac atgtacttta taagtattgg tttgggtgtt ccttccaaga aggactatag     4500

ttagtaataa atgcctataa taacatattt atttttatac atttatttct aatgaaaaaa     4560

acttttaaat tatatcgctt ttgtggaagt gcatataaaa tagagtattt atacaatata     4620

tgttactaga aataaaagaa cacttttgga aaaaaaaaaa aaaaaaaaaa                4670


<210>  18
<211>  967
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gln Arg Ala Val Pro Glu Gly Phe Gly Arg Arg Lys Leu Gly Ser 
1               5                   10                  15      


Asp Met Gly Asn Ala Glu Arg Ala Pro Gly Ser Arg Ser Phe Gly Pro 
            20                  25                  30          


Val Pro Thr Leu Leu Leu Leu Ala Ala Ala Leu Leu Ala Val Ser Asp 
        35                  40                  45              


Ala Leu Gly Arg Pro Ser Glu Glu Asp Glu Glu Leu Val Val Pro Glu 
    50                  55                  60                  


Leu Glu Arg Ala Pro Gly His Gly Thr Thr Arg Leu Arg Leu His Ala 
65                  70                  75                  80  


Phe Asp Gln Gln Leu Asp Leu Glu Leu Arg Pro Asp Ser Ser Phe Leu 
                85                  90                  95      


Ala Pro Gly Phe Thr Leu Gln Asn Val Gly Arg Lys Ser Gly Ser Glu 
            100                 105                 110         


Thr Pro Leu Pro Glu Thr Asp Leu Ala His Cys Phe Tyr Ser Gly Thr 
        115                 120                 125             


Val Asn Gly Asp Pro Ser Ser Ala Ala Ala Leu Ser Leu Cys Glu Gly 
    130                 135                 140                 


Val Arg Gly Ala Phe Tyr Leu Leu Gly Glu Ala Tyr Phe Ile Gln Pro 
145                 150                 155                 160 


Leu Pro Ala Ala Ser Glu Arg Leu Ala Thr Ala Ala Pro Gly Glu Lys 
                165                 170                 175     


Pro Pro Ala Pro Leu Gln Phe His Leu Leu Arg Arg Asn Arg Gln Gly 
            180                 185                 190         


Asp Val Gly Gly Thr Cys Gly Val Val Asp Asp Glu Pro Arg Pro Thr 
        195                 200                 205             


Gly Lys Ala Glu Thr Glu Asp Glu Asp Glu Gly Thr Glu Gly Glu Asp 
    210                 215                 220                 


Glu Gly Ala Gln Trp Ser Pro Gln Asp Pro Ala Leu Gln Gly Val Gly 
225                 230                 235                 240 


Gln Pro Thr Gly Thr Gly Ser Ile Arg Lys Lys Arg Phe Val Ser Ser 
                245                 250                 255     


His Arg Tyr Val Glu Thr Met Leu Val Ala Asp Gln Ser Met Ala Glu 
            260                 265                 270         


Phe His Gly Ser Gly Leu Lys His Tyr Leu Leu Thr Leu Phe Ser Val 
        275                 280                 285             


Ala Ala Arg Leu Tyr Lys His Pro Ser Ile Arg Asn Ser Val Ser Leu 
    290                 295                 300                 


Val Val Val Lys Ile Leu Val Ile His Asp Glu Gln Lys Gly Pro Glu 
305                 310                 315                 320 


Val Thr Ser Asn Ala Ala Leu Thr Leu Arg Asn Phe Cys Asn Trp Gln 
                325                 330                 335     


Lys Gln His Asn Pro Pro Ser Asp Arg Asp Ala Glu His Tyr Asp Thr 
            340                 345                 350         


Ala Ile Leu Phe Thr Arg Gln Asp Leu Cys Gly Ser Gln Thr Cys Asp 
        355                 360                 365             


Thr Leu Gly Met Ala Asp Val Gly Thr Val Cys Asp Pro Ser Arg Ser 
    370                 375                 380                 


Cys Ser Val Ile Glu Asp Asp Gly Leu Gln Ala Ala Phe Thr Thr Ala 
385                 390                 395                 400 


His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Ala Lys Gln 
                405                 410                 415     


Cys Ala Ser Leu Asn Gly Val Asn Gln Asp Ser His Met Met Ala Ser 
            420                 425                 430         


Met Leu Ser Asn Leu Asp His Ser Gln Pro Trp Ser Pro Cys Ser Ala 
        435                 440                 445             


Tyr Met Ile Thr Ser Phe Leu Asp Asn Gly His Gly Glu Cys Leu Met 
    450                 455                 460                 


Asp Lys Pro Gln Asn Pro Ile Gln Leu Pro Gly Asp Leu Pro Gly Thr 
465                 470                 475                 480 


Ser Tyr Asp Ala Asn Arg Gln Cys Gln Phe Thr Phe Gly Glu Asp Ser 
                485                 490                 495     


Lys His Cys Pro Asp Ala Ala Ser Thr Cys Ser Thr Leu Trp Cys Thr 
            500                 505                 510         


Gly Thr Ser Gly Gly Val Leu Val Cys Gln Thr Lys His Phe Pro Trp 
        515                 520                 525             


Ala Asp Gly Thr Ser Cys Gly Glu Gly Lys Trp Cys Ile Asn Gly Lys 
    530                 535                 540                 


Cys Val Asn Lys Thr Asp Arg Lys His Phe Asp Thr Pro Phe His Gly 
545                 550                 555                 560 


Ser Trp Gly Met Trp Gly Pro Trp Gly Asp Cys Ser Arg Thr Cys Gly 
                565                 570                 575     


Gly Gly Val Gln Tyr Thr Met Arg Glu Cys Asp Asn Pro Val Pro Lys 
            580                 585                 590         


Asn Gly Gly Lys Tyr Cys Glu Gly Lys Arg Val Arg Tyr Arg Ser Cys 
        595                 600                 605             


Asn Leu Glu Asp Cys Pro Asp Asn Asn Gly Lys Thr Phe Arg Glu Glu 
    610                 615                 620                 


Gln Cys Glu Ala His Asn Glu Phe Ser Lys Ala Ser Phe Gly Ser Gly 
625                 630                 635                 640 


Pro Ala Val Glu Trp Ile Pro Lys Tyr Ala Gly Val Ser Pro Lys Asp 
                645                 650                 655     


Arg Cys Lys Leu Ile Cys Gln Ala Lys Gly Ile Gly Tyr Phe Phe Val 
            660                 665                 670         


Leu Gln Pro Lys Val Val Asp Gly Thr Pro Cys Ser Pro Asp Ser Thr 
        675                 680                 685             


Ser Val Cys Val Gln Gly Gln Cys Val Lys Ala Gly Cys Asp Arg Ile 
    690                 695                 700                 


Ile Asp Ser Lys Lys Lys Phe Asp Lys Cys Gly Val Cys Gly Gly Asn 
705                 710                 715                 720 


Gly Ser Thr Cys Lys Lys Ile Ser Gly Ser Val Thr Ser Ala Lys Pro 
                725                 730                 735     


Gly Tyr His Asp Ile Ile Thr Ile Pro Thr Gly Ala Thr Asn Ile Glu 
            740                 745                 750         


Val Lys Gln Arg Asn Gln Arg Gly Ser Arg Asn Asn Gly Ser Phe Leu 
        755                 760                 765             


Ala Ile Lys Ala Ala Asp Gly Thr Tyr Ile Leu Asn Gly Asp Tyr Thr 
    770                 775                 780                 


Leu Ser Thr Leu Glu Gln Asp Ile Met Tyr Lys Gly Val Val Leu Arg 
785                 790                 795                 800 


Tyr Ser Gly Ser Ser Ala Ala Leu Glu Arg Ile Arg Ser Phe Ser Pro 
                805                 810                 815     


Leu Lys Glu Pro Leu Thr Ile Gln Val Leu Thr Val Gly Asn Ala Leu 
            820                 825                 830         


Arg Pro Lys Ile Lys Tyr Thr Tyr Phe Val Lys Lys Lys Lys Glu Ser 
        835                 840                 845             


Phe Asn Ala Ile Pro Thr Phe Ser Ala Trp Val Ile Glu Glu Trp Gly 
    850                 855                 860                 


Glu Cys Ser Lys Ser Cys Glu Leu Gly Trp Gln Arg Arg Leu Val Glu 
865                 870                 875                 880 


Cys Arg Asp Ile Asn Gly Gln Pro Ala Ser Glu Cys Ala Lys Glu Val 
                885                 890                 895     


Lys Pro Ala Ser Thr Arg Pro Cys Ala Asp His Pro Cys Pro Gln Trp 
            900                 905                 910         


Gln Leu Gly Glu Trp Ser Ser Cys Ser Lys Thr Cys Gly Lys Gly Tyr 
        915                 920                 925             


Lys Lys Arg Ser Leu Lys Cys Leu Ser His Asp Gly Gly Val Leu Ser 
    930                 935                 940                 


His Glu Ser Cys Asp Pro Leu Lys Lys Pro Lys His Phe Ile Asp Phe 
945                 950                 955                 960 


Cys Thr Met Ala Glu Cys Ser 
                965         


<210>  19
<211>  5821
<212>  DNA
<213>  Homo sapiens

<400>  19
gctttgccca gtagttggaa agtgaactcg actcgtgatg gttctcctgt cactttggtt       60

gatagcagcc gctctggtag aggttaggac ttcagctgat ggacaagctg gtaatgaaga      120

aatggtgcaa atagatttac caataaagag atatagagag tatgagctgg tgactccagt      180

cagcacaaat ctagaaggac gctatctctc ccatactctt tctgcgagtc acaaaaagag      240

gtcagcgagg gacgtgtctt ccaaccctga gcagttgttc tttaacatca cggcatttgg      300

aaaagatttt catctgcgac taaagcccaa cactcaacta gtagctcctg gggctgttgt      360

ggagtggcat gagacatctc tggtgcctgg gaatataacc gatcccatta acaaccatca      420

accaggaagt gctacgtata gaatccggaa aacagagcct ttgcagacta actgtgctta      480

tgttggtgac atcgtggaca ttccaggaac ctctgttgcc atcagcaact gtgatggtct      540

ggctggaatg ataaaaagtg ataatgaaga gtatttcatt gaacccttgg aaagaggtaa      600

acagatggag gaagaaaaag gaaggattca tgttgtctac aagagatcag ctgtagaaca      660

ggctcccata gacatgtcca aagacttcca ctacagagag tcggacctgg aaggccttga      720

tgatctaggt actgtttatg gcaacatcca ccagcagctg aatgaaacaa tgagacgccg      780

cagacacgcg ggagaaaacg attacaatat cgaggtactg ctgggagtgg atgactctgt      840

ggtccgtttc catggcaaag agcacgtcca aaactacctc ctgaccctaa tgaacattgt      900

gaatgaaatt taccatgatg agtccctcgg agtgcatata aatgtggtcc tggtgcgcat      960

gataatgctg ggatatgcaa agtccatcag cctcatagaa aggggaaacc catccagaag     1020

cttggagaat gtgtgtcgct gggcgtccca acagcaaaga tctgatctca accactctga     1080

acaccatgac catgcaattt ttttaaccag gcaagacttt ggacctgctg gaatgcaagg     1140

atatgctcca gtcaccggca tgtgtcatcc agtgagaagt tgtaccctga atcatgagga     1200

tggtttttca tctgcttttg tagtagccca tgaaacgggc catgtgttgg gaatggagca     1260

tgatggacaa ggcaacaggt gtggtgatga gactgctatg ggaagtgtca tggctccctt     1320

ggtacaagca gcattccatc gttaccactg gtcccgatgc agtggtcaag aactgaaaag     1380

atatatccat tcctatgact gtctccttga tgaccctttt gatcatgatt ggcctaaact     1440

cccagaactt cctggaatca attattctat ggatgagcaa tgtcgttttg attttggtgt     1500

tggctataaa atgtgcaccg cgttccgaac ctttgaccca tgtaaacagc tgtggtgtag     1560

ccatcctgat aatccctact tttgtaagac taaaaaggga cctccacttg atgggactga     1620

atgtgctgct ggaaaatggt gctataaggg tcattgcatg tggaagaatg ctaatcagca     1680

aaaacaagat ggcaattggg ggtcatggac taaatttggc tcctgttctc ggacatgtgg     1740

aactggtgtt cgtttcagaa cacgccagtg caataatccc atgcccatca atggtggtca     1800

ggattgtcct ggtgttaatt ttgagtacca gctttgtaac acagaagaat gccaaaaaca     1860

ctttgaggac ttcagagcac agcagtgtca gcagcgaaac tcccactttg aataccagaa     1920

taccaaacac cactggttgc catatgaaca tcctgacccc aagaaaagat gccaccttta     1980

ctgtcagtcc aaggagactg gagatgttgc ttacatgaaa caactggtgc atgatggaac     2040

gcactgttct tacaaagatc catatagcat atgtgtgcga ggagagtgtg tgaaagtggg     2100

ctgtgataaa gaaattggtt ctaataaggt tgaggataag tgtggtgtct gtggaggaga     2160

taattcccac tgccgaaccg tgaaggggac atttaccaga actcccagga agcttgggta     2220

ccttaagatg tttgatatac cccctggggc tagacatgtg ttaatccaag aagacgaggc     2280

ttctcctcat attcttgcta ttaagaacca ggctacaggc cattatattt taaatggcaa     2340

aggggaggaa gccaagtcgc ggaccttcat agatcttggt gtggagtggg attataacat     2400

tgaagatgac attgaaagtc ttcacaccga tggaccttta catgatcctg ttattgtttt     2460

gattatacct caagaaaatg atacccgctc tagcctgaca tataagtaca tcatccatga     2520

agactctgta cctacaatca acagcaacaa tgtcatccag gaagaattag atacttttga     2580

gtgggctttg aagagctggt ctcagtgttc caaaccctgt ggtggaggtt tccagtacac     2640

taaatatgga tgccgtagga aaagtgataa taaaatggtc catcgcagct tctgtgaggc     2700

caacaaaaag ccgaaaccta ttagacgaat gtgcaatatt caagagtgta cacatccact     2760

ctgggtagca gaagaatggg aacactgcac caaaacctgt ggaagttctg gctatcagct     2820

tcgcactgta cgctgccttc agccactcct tgatggcacc aaccgctctg tgcacagcaa     2880

atactgcatg ggtgaccgtc ccgagagccg ccggccctgt aacagagtgc cctgccctgc     2940

acagtggaaa acaggaccct ggagtgagtg ttcagtgacc tgcggtgaag gaacggaggt     3000

gaggcaggtc ctctgcaggg ctggggacca ctgtgatggt gaaaagcctg agtcggtcag     3060

agcctgtcaa ctgcctcctt gtaatgatga accatgtttg ggagacaagt ccatattctg     3120

tcaaatggaa gtgttggcac gatactgctc cataccaggt tataacaagt tatgttgtga     3180

gtcctgcagc aagcgcagta gcaccctgcc accaccatac cttctagaag ctgctgaaac     3240

tcatgatgat gtcatctcta accctagtga cctccctaga tctctagtga tgcctacatc     3300

tttggttcct tatcattcag agacccctgc aaagaagatg tctttgagta gcatctcttc     3360

agtgggaggt ccaaatgcat atgctgcttt caggccaaac agtaaacctg atggtgctaa     3420

tttacgccag aggagtgctc agcaagcagg aagtaagact gtgagactgg tcaccgtacc     3480

atcctcccca cccaccaaga gggtccacct cagttcagct tcacaaatgg ctgctgcttc     3540

cttctttgca gccagtgatt caataggtgc ttcttctcag gcaagaacct caaagaaaga     3600

tggaaagatc attgacaaca gacgtccgac aagatcatcc accttagaaa gatgagaaag     3660

tgaaccaaaa aggctagaaa ccagaggaaa acctggacaa cctctctctt cccatggtgc     3720

atatgcttgt ttaaagtgga aatctctata gatcgtcagc tcattttatc tgtaattgga     3780

agaacagaaa gtgctggctc actttctagt tgctttcatc ctccttttgt tctgcattga     3840

ctcatttacc agaattcatt ggaagaaatc accaaagatt attacaaaag aaaaatatgt     3900

tgctaagatt gtgttggtcg ctctctgaag cagaaaaggg actggaacca attgtgcata     3960

tcagctgact ttttgtttgt tttagaaaag ttacagtaaa aattaaaaag agataccaat     4020

ggtttacact ttaacaagaa attttggata tggaacaaag aattcttaga cttgtattcc     4080

tatttatcta tattagaaat attgtatgag caaatttgca gctgttgtgt aaatactgta     4140

tattgcaaaa atcagtatta ttttaagaga tgtgttctca aatgattgtt tactatatta     4200

catttctgga tgttctaggt gcctgtcgtt gagtattgcc ttgtttgaca ttctataggt     4260

taattttcaa agcagagtat tacaaaagag aagttagaat tacagctact gacaatataa     4320

agggttttgt tgaatcaaca atgtgatacg taaattatag aaaaagaaaa gaaacacaaa     4380

agctatagat atacagatat cagcttacct attgccttct atacttataa tttaaaggat     4440

tggtgtctta gtacacttgt ggtcacaggg atcaacgaat agtaaataat gaactcgtgc     4500

aagacaaaac tgaaaccctc tttccaggac ctcagtaggc accgttgagg tgtcctttgt     4560

ttttgtgtgt gtgtgttctt ttttaatttt cgcattgttg acagatacaa acagttatac     4620

tcaatgtact gtaataatcg caaaggaaaa agttttggga taacttattt gtatgttggt     4680

agctgagaaa aatatcatca gtctagaatt gatatttgag tatagtagag ctttggggct     4740

ttgaaggcag gttcaagaaa gcatatgtcg atggttgaga tatttatttt ccatatggtt     4800

catgttcaaa tgttcacaac cacaatgcat ctgactgcaa taatgtgcta ataatttatg     4860

tcagtagtca ccttgctcac agcaaagcca gaaatgctct ctccagggag tagatgtaaa     4920

gtacttgtac atagaattca gaactgaaga tatttattaa aagttgattt tttttcttga     4980

tagtattttt atgtactaaa tatttacact aatatcaatt acatattttg gtaaactaga     5040

gagacataat tagagatgca tgctttgttc tgtgcataga gacctttaag caaactacta     5100

cagccaactc aaaagctaaa actgaacaaa tttgatgtta tgcaaacatc ttgcattttt     5160

agtagttgat attaagttga tgacttgttt cccttcaagg aaacattaaa ttgtatggac     5220

tcagctagct gttcaatgaa attgtgaatt agaaacattt ttaaaagttt ttgaaagaga     5280

taagtgcatc atgaattaca tgtacatgag aggagatagt gatatcagca taatgatttt     5340

gaggtcagta cctgagctgt ctaaaaatat attatacaaa ctaaaatgta gatgaattaa     5400

cctctcaaag cacagaatgt gcaagaactt ttgcatttta atcgttgtaa actaacagct     5460

taaactattg actctatacc tctaaagaat tgctgctact ttgtgcaaga actttgaagg     5520

tcaaattagg caaattccag atagtaaaac aatccctaag ccttaagtct tttttttttc     5580

ctaaaaattc ccatagaata aaattctctc tagtttactt gtgtgtgcat acatctcatc     5640

cacaggggaa gataaagatg gtcacacaaa cagtttccat aaagatgtac atattcatta     5700

tacttctgac ctttgggctt tcttttctac taagctaaaa attccttttt atcaaagtgt     5760

acactactga tgctgtttgt tgtactgaga gcacgtacca ataaaaatgt taacaaaata     5820

t                                                                     5821


<210>  20
<211>  1205
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Val Leu Leu Ser Leu Trp Leu Ile Ala Ala Ala Leu Val Glu Val 
1               5                   10                  15      


Arg Thr Ser Ala Asp Gly Gln Ala Gly Asn Glu Glu Met Val Gln Ile 
            20                  25                  30          


Asp Leu Pro Ile Lys Arg Tyr Arg Glu Tyr Glu Leu Val Thr Pro Val 
        35                  40                  45              


Ser Thr Asn Leu Glu Gly Arg Tyr Leu Ser His Thr Leu Ser Ala Ser 
    50                  55                  60                  


His Lys Lys Arg Ser Ala Arg Asp Val Ser Ser Asn Pro Glu Gln Leu 
65                  70                  75                  80  


Phe Phe Asn Ile Thr Ala Phe Gly Lys Asp Phe His Leu Arg Leu Lys 
                85                  90                  95      


Pro Asn Thr Gln Leu Val Ala Pro Gly Ala Val Val Glu Trp His Glu 
            100                 105                 110         


Thr Ser Leu Val Pro Gly Asn Ile Thr Asp Pro Ile Asn Asn His Gln 
        115                 120                 125             


Pro Gly Ser Ala Thr Tyr Arg Ile Arg Lys Thr Glu Pro Leu Gln Thr 
    130                 135                 140                 


Asn Cys Ala Tyr Val Gly Asp Ile Val Asp Ile Pro Gly Thr Ser Val 
145                 150                 155                 160 


Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly Met Ile Lys Ser Asp Asn 
                165                 170                 175     


Glu Glu Tyr Phe Ile Glu Pro Leu Glu Arg Gly Lys Gln Met Glu Glu 
            180                 185                 190         


Glu Lys Gly Arg Ile His Val Val Tyr Lys Arg Ser Ala Val Glu Gln 
        195                 200                 205             


Ala Pro Ile Asp Met Ser Lys Asp Phe His Tyr Arg Glu Ser Asp Leu 
    210                 215                 220                 


Glu Gly Leu Asp Asp Leu Gly Thr Val Tyr Gly Asn Ile His Gln Gln 
225                 230                 235                 240 


Leu Asn Glu Thr Met Arg Arg Arg Arg His Ala Gly Glu Asn Asp Tyr 
                245                 250                 255     


Asn Ile Glu Val Leu Leu Gly Val Asp Asp Ser Val Val Arg Phe His 
            260                 265                 270         


Gly Lys Glu His Val Gln Asn Tyr Leu Leu Thr Leu Met Asn Ile Val 
        275                 280                 285             


Asn Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile Asn Val Val 
    290                 295                 300                 


Leu Val Arg Met Ile Met Leu Gly Tyr Ala Lys Ser Ile Ser Leu Ile 
305                 310                 315                 320 


Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Asn Val Cys Arg Trp Ala 
                325                 330                 335     


Ser Gln Gln Gln Arg Ser Asp Leu Asn His Ser Glu His His Asp His 
            340                 345                 350         


Ala Ile Phe Leu Thr Arg Gln Asp Phe Gly Pro Ala Gly Met Gln Gly 
        355                 360                 365             


Tyr Ala Pro Val Thr Gly Met Cys His Pro Val Arg Ser Cys Thr Leu 
    370                 375                 380                 


Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Val Ala His Glu Thr 
385                 390                 395                 400 


Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn Arg Cys Gly 
                405                 410                 415     


Asp Glu Thr Ala Met Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala 
            420                 425                 430         


Phe His Arg Tyr His Trp Ser Arg Cys Ser Gly Gln Glu Leu Lys Arg 
        435                 440                 445             


Tyr Ile His Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp His Asp 
    450                 455                 460                 


Trp Pro Lys Leu Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu 
465                 470                 475                 480 


Gln Cys Arg Phe Asp Phe Gly Val Gly Tyr Lys Met Cys Thr Ala Phe 
                485                 490                 495     


Arg Thr Phe Asp Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn 
            500                 505                 510         


Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Glu 
        515                 520                 525             


Cys Ala Ala Gly Lys Trp Cys Tyr Lys Gly His Cys Met Trp Lys Asn 
    530                 535                 540                 


Ala Asn Gln Gln Lys Gln Asp Gly Asn Trp Gly Ser Trp Thr Lys Phe 
545                 550                 555                 560 


Gly Ser Cys Ser Arg Thr Cys Gly Thr Gly Val Arg Phe Arg Thr Arg 
                565                 570                 575     


Gln Cys Asn Asn Pro Met Pro Ile Asn Gly Gly Gln Asp Cys Pro Gly 
            580                 585                 590         


Val Asn Phe Glu Tyr Gln Leu Cys Asn Thr Glu Glu Cys Gln Lys His 
        595                 600                 605             


Phe Glu Asp Phe Arg Ala Gln Gln Cys Gln Gln Arg Asn Ser His Phe 
    610                 615                 620                 


Glu Tyr Gln Asn Thr Lys His His Trp Leu Pro Tyr Glu His Pro Asp 
625                 630                 635                 640 


Pro Lys Lys Arg Cys His Leu Tyr Cys Gln Ser Lys Glu Thr Gly Asp 
                645                 650                 655     


Val Ala Tyr Met Lys Gln Leu Val His Asp Gly Thr His Cys Ser Tyr 
            660                 665                 670         


Lys Asp Pro Tyr Ser Ile Cys Val Arg Gly Glu Cys Val Lys Val Gly 
        675                 680                 685             


Cys Asp Lys Glu Ile Gly Ser Asn Lys Val Glu Asp Lys Cys Gly Val 
    690                 695                 700                 


Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys Gly Thr Phe Thr 
705                 710                 715                 720 


Arg Thr Pro Arg Lys Leu Gly Tyr Leu Lys Met Phe Asp Ile Pro Pro 
                725                 730                 735     


Gly Ala Arg His Val Leu Ile Gln Glu Asp Glu Ala Ser Pro His Ile 
            740                 745                 750         


Leu Ala Ile Lys Asn Gln Ala Thr Gly His Tyr Ile Leu Asn Gly Lys 
        755                 760                 765             


Gly Glu Glu Ala Lys Ser Arg Thr Phe Ile Asp Leu Gly Val Glu Trp 
    770                 775                 780                 


Asp Tyr Asn Ile Glu Asp Asp Ile Glu Ser Leu His Thr Asp Gly Pro 
785                 790                 795                 800 


Leu His Asp Pro Val Ile Val Leu Ile Ile Pro Gln Glu Asn Asp Thr 
                805                 810                 815     


Arg Ser Ser Leu Thr Tyr Lys Tyr Ile Ile His Glu Asp Ser Val Pro 
            820                 825                 830         


Thr Ile Asn Ser Asn Asn Val Ile Gln Glu Glu Leu Asp Thr Phe Glu 
        835                 840                 845             


Trp Ala Leu Lys Ser Trp Ser Gln Cys Ser Lys Pro Cys Gly Gly Gly 
    850                 855                 860                 


Phe Gln Tyr Thr Lys Tyr Gly Cys Arg Arg Lys Ser Asp Asn Lys Met 
865                 870                 875                 880 


Val His Arg Ser Phe Cys Glu Ala Asn Lys Lys Pro Lys Pro Ile Arg 
                885                 890                 895     


Arg Met Cys Asn Ile Gln Glu Cys Thr His Pro Leu Trp Val Ala Glu 
            900                 905                 910         


Glu Trp Glu His Cys Thr Lys Thr Cys Gly Ser Ser Gly Tyr Gln Leu 
        915                 920                 925             


Arg Thr Val Arg Cys Leu Gln Pro Leu Leu Asp Gly Thr Asn Arg Ser 
    930                 935                 940                 


Val His Ser Lys Tyr Cys Met Gly Asp Arg Pro Glu Ser Arg Arg Pro 
945                 950                 955                 960 


Cys Asn Arg Val Pro Cys Pro Ala Gln Trp Lys Thr Gly Pro Trp Ser 
                965                 970                 975     


Glu Cys Ser Val Thr Cys Gly Glu Gly Thr Glu Val Arg Gln Val Leu 
            980                 985                 990         


Cys Arg Ala Gly Asp His Cys Asp  Gly Glu Lys Pro Glu  Ser Val Arg 
        995                 1000                 1005             


Ala Cys  Gln Leu Pro Pro Cys  Asn Asp Glu Pro Cys  Leu Gly Asp 
    1010                 1015                 1020             


Lys Ser  Ile Phe Cys Gln Met  Glu Val Leu Ala Arg  Tyr Cys Ser 
    1025                 1030                 1035             


Ile Pro  Gly Tyr Asn Lys Leu  Cys Cys Glu Ser Cys  Ser Lys Arg 
    1040                 1045                 1050             


Ser Ser  Thr Leu Pro Pro Pro  Tyr Leu Leu Glu Ala  Ala Glu Thr 
    1055                 1060                 1065             


His Asp  Asp Val Ile Ser Asn  Pro Ser Asp Leu Pro  Arg Ser Leu 
    1070                 1075                 1080             


Val Met  Pro Thr Ser Leu Val  Pro Tyr His Ser Glu  Thr Pro Ala 
    1085                 1090                 1095             


Lys Lys  Met Ser Leu Ser Ser  Ile Ser Ser Val Gly  Gly Pro Asn 
    1100                 1105                 1110             


Ala Tyr  Ala Ala Phe Arg Pro  Asn Ser Lys Pro Asp  Gly Ala Asn 
    1115                 1120                 1125             


Leu Arg  Gln Arg Ser Ala Gln  Gln Ala Gly Ser Lys  Thr Val Arg 
    1130                 1135                 1140             


Leu Val  Thr Val Pro Ser Ser  Pro Pro Thr Lys Arg  Val His Leu 
    1145                 1150                 1155             


Ser Ser  Ala Ser Gln Met Ala  Ala Ala Ser Phe Phe  Ala Ala Ser 
    1160                 1165                 1170             


Asp Ser  Ile Gly Ala Ser Ser  Gln Ala Arg Thr Ser  Lys Lys Asp 
    1175                 1180                 1185             


Gly Lys  Ile Ile Asp Asn Arg  Arg Pro Thr Arg Ser  Ser Thr Leu 
    1190                 1195                 1200             


Glu Arg  
    1205 


<210>  21
<211>  9663
<212>  DNA
<213>  Homo sapiens

<400>  21
ataaattcat tgttccacct cctcgcatct tcacagcgct cgcgctgctc tcggcgctcg       60

cagctgccga ctggggatga cggcgggcag gaggagaccg cagccgaagg gacacagaca      120

cgccgcttca ccagctcgcc tcaggctgcc cccctgcatt tttgttttaa tttttacggc      180

tttttcccct ctctttcttc ccttcctcct ggtcccagca gagccaagga aacccacaaa      240

ataagaaagg aagtgggccc cggagcttgg aacctccaca gccggcttgt ccagcgcagc      300

gcgggggcgg gaggctgcgc gcaccagttg ccagcccggt gcgcggtacc tttccttact      360

tttcttgaaa cagcgatcgt gcctgcattt ggtggttttt tggtttttgt ttttttcctt      420

ttcccgtatt tgctgaatct ccactatccg actttttttt tttaatcttt tctttccccc      480

cccccccacc ccacctcttt ctggagcacg aatccaaaca ttttcccaag caacaaagaa      540

aagttcgcac gctggcaccg cagcccggac aggctggcgc tgctgccggg cccccctccc      600

tccgacactt gactcaatcc tgcaagcaag tgtgtgtgtg tccccatccc ccgccccgtt      660

aacttcatag caaataacaa atacccataa agtcccagtc gcgcagcccc tccccgcggg      720

cagcgcacta tgctgctcgg gtgggcgtcc ctgctgctgt gcgcgttccg cctgcccctg      780

gccgcggtcg gccccgccgc gacacctgcc caggataaag ccgggcagcc tccgactgct      840

gcagcagccg cccagccccg ccggcggcag ggggaggagg tgcaggagcg agccgagcct      900

cccggccacc cgcaccccct ggcgcagcgg cgcaggagca aggggctggt gcagaacatc      960

gaccaactct actccggcgg cggcaaggtg ggctacctcg tctacgcggg cggccggagg     1020

ttcctcttgg acctggagcg agatggttcg gtgggcattg ctggcttcgt gcccgcagga     1080

ggcgggacga gtgcgccctg gcgccaccgg agccactgct tctatcgggg cacagtggac     1140

ggtagtcccc gctctctggc tgtctttgac ctctgtgggg gtctcgacgg cttcttcgcg     1200

gtcaagcacg cgcgctacac cctaaagcca ctgctgcgcg gaccctgggc ggaggaagaa     1260

aaggggcgcg tgtacgggga tgggtccgca cggatcctgc acgtctacac ccgcgagggc     1320

ttcagcttcg aggccctgcc gccgcgcgcc agctgcgaaa cccccgcgtc cacaccggag     1380

gcccacgagc atgctccggc gcacagcaac ccgagcggac gcgcagcact ggcctcgcag     1440

ctcttggacc agtccgctct ctcgcccgct gggggctcag gaccgcagac gtggtggcgg     1500

cggcggcgcc gctccatctc ccgggcccgc caggtggagc tgcttctggt ggctgacgcg     1560

tccatggcgc ggttgtatgg ccggggcctg cagcattacc tgctgaccct ggcctccatc     1620

gccaataggc tgtacagcca tgctagcatc gagaaccaca tccgcctggc cgtggtgaag     1680

gtggtggtgc taggcgacaa ggacaagagc ctggaagtga gcaagaacgc tgccaccaca     1740

ctcaagaact tttgcaagtg gcagcaccaa cacaaccagc tgggagatga ccatgaggag     1800

cactacgatg cagctatcct gtttactcgg gaggatttat gtgggcatca ttcatgtgac     1860

accctgggaa tggcagacgt tgggaccata tgttctccag agcgcagctg tgctgtgatt     1920

gaagacgatg gcctccacgc agccttcact gtggctcacg aaatcggaca tttacttggc     1980

ctctcccatg acgattccaa attctgtgaa gagacctttg gttccacaga agataagcgc     2040

ttaatgtctt ccatccttac cagcattgat gcatctaagc cctggtccaa atgcacttca     2100

gccaccatca cagaattcct ggatgatggc catggtaact gtttgctgga cctaccacga     2160

aagcagatcc tgggccccga agaactccca ggacagacct acgatgccac ccagcagtgc     2220

aacctgacat tcgggcctga gtactccgtg tgtcccggca tggatgtctg tgctcgcctg     2280

tggtgtgctg tggtacgcca gggccagatg gtctgtctga ccaagaagct gcctgcggtg     2340

gaagggacgc cttgtggaaa ggggagaatc tgcctgcagg gcaaatgtgt ggacaaaacc     2400

aagaaaaaat attattcaac gtcaagccat ggcaactggg gatcttgggg atcctggggc     2460

cagtgttctc gctcatgtgg aggaggagtg cagtttgcct atcgtcactg taataaccct     2520

gctcccagaa acaacggacg ctactgcaca gggaagaggg ccatctaccg ctcctgcagt     2580

ctcatgccct gcccacccaa tggtaaatca tttcgtcatg aacagtgtga ggccaaaaat     2640

ggctatcagt ctgatgcaaa aggagtcaaa acttttgtgg aatgggttcc caaatatgca     2700

ggtgtcctgc cagcggatgt gtgcaagctg acctgcagag ccaagggcac tggctactat     2760

gtggtatttt ctccaaaggt gaccgatggc actgaatgta ggctgtacag taattccgtc     2820

tgcgtccggg ggaagtgtgt gagaactggc tgtgacggca tcattggctc aaagctgcag     2880

tatgacaagt gcggagtatg tggaggagac aactccagct gtacaaagat tgttggaacc     2940

tttaataaga aaagtaaggg ttacactgac gtggtgagga ttcctgaagg ggcaacccac     3000

ataaaagttc gacagttcaa agccaaagac cagactagat tcactgccta tttagccctg     3060

aaaaagaaaa acggtgagta ccttatcaat ggaaagtaca tgatctccac ttcagagact     3120

atcattgaca tcaatggaac agtcatgaac tatagcggtt ggagccacag ggatgacttc     3180

ctgcatggca tgggctactc tgccacgaag gaaattctaa tagtgcagat tcttgcaaca     3240

gaccccacta aaccattaga tgtccgttat agcttttttg ttcccaagaa gtccactcca     3300

aaagtaaact ctgtcactag tcatggcagc aataaagtgg gatcacacac ttcgcagccg     3360

cagtgggtca cgggcccatg gctcgcctgc tctaggacct gtgacacagg ttggcacacc     3420

agaacggtgc agtgccagga tggaaaccgg aagttagcaa aaggatgtcc tctctcccaa     3480

aggccttctg cgtttaagca atgcttgttg aagaaatgtt agcctgtggt tatgatctta     3540

tgcacaaaga taactggagg attcagcact gatgcagtcg tggtgaacag gaggtctacc     3600

taacgcacag aaagtcatgc ttcagtgaca ttgtcaacag gagtccaatt atgggcagaa     3660

tctgctctct gtgaccaaaa gaggatgtgc actgcttcac gtgacagtgg tgaccttgca     3720

atatagaaaa acttgggagt tattgaacat cccctgggct tacaagaaac actgatgaat     3780

gtaaaatcag gggacatttg aagatggcag aactgtctcc cccttgtcac ctacctctga     3840

tagaatgtct ttaatggtat cataatcatt ttcacccata atacacagta gcttcttctt     3900

actgtttgta aatacattct cccttggtat gtcactttat atcccctggt tctattaaaa     3960

tatccatata tatttctata aaaaaagtgt ttgaccaaag taggtctgca gctatttcaa     4020

cttccttccg tttccagaaa gagctgtgga tattttactg gaaattaaga acttgctgct     4080

gttttaataa gatgtagtat attttctgac tacaggagat aaaatttcag tcaaaaaacc     4140

attttgacag caagtatctt ctgagaaatt ttgaaaagta aatagatctc agtgtatcta     4200

gtcacttaaa tacatacacg ggttcattta cttaaacctt tgactgcctg tatttttttc     4260

aggtagctag ccaaattaat gcataatttc agatgtagaa gtagggtttg cgtgtgtgtg     4320

tgtgatcata ctcaagagtc taaaaactag tttccttgtg ttggaaattt aaaaggaaaa     4380

aaatcgtatt tcactgtgtt ttcaatttat attttcacaa ctactttctc tctccagagc     4440

tttcatctga tatctcacaa tgtatgatat acgtacaaaa cacacagcaa gttttctatc     4500

atgtccaaca cattcaacac tggtatacct cctaccagca agcctttaaa atgcatttgt     4560

gtttgcttat ttgttttgtt caagggttca gtaagaccta caatgttttg tatttcttga     4620

cttattttat tagaaacatt aaagatcact tggtagttag ccacattgag aagtggttat     4680

cattgttaat gtggttaatg ccaaaaagtg gttaatatta ataagactgt ttccacacca     4740

taggcaataa tttcttaatt taaaaaatct aagtatattc ctattgtact aaatattttt     4800

cccaactgga aagcacttga ttgtacccgt aagtgtttga gtgatgacat gtgatgattt     4860

tcagaaagtt gttgtttttg tttccatagc ctgtttaagt aggttgtaag tttgaatagt     4920

tagacatgga aattatttta taagcacaca cctaaagata tctttttaga tgataaaatg     4980

tacacccccc catcaccaac ctcacaactt agaaaatcta agttgtttga tttctttggg     5040

atttcttttg ttgtgaaaca ctgcaaagcc aatttttctt tataaaaatt catagtaatc     5100

ctgccaaatg tgcctattgt taaagatttg catgtgaaga tcttagggaa ccactgtttg     5160

agttctacaa gctcatgaga gtttattttt attataagat gtttttaata taaaagaatt     5220

atgtaactga tcactatatt acatcatttc agtgggccag gaaaatagat gtcttgctgt     5280

tttcagtatt ttcttaagaa attgctttta aaacaaataa ttgttttaca aaaccaataa     5340

ttatcctttg aattttcata gactgacttt gcttttgacg tagaaatttt ttttctcaat     5400

aaattatcac tttgagaaat gaggcctgta caaggctgat aacctatatg tgatggagat     5460

cacccaatgc caagggcaga aagcaaacct agttaaatag gtgagaaaaa aaataataat     5520

cccagtgcca tttgtctgtg caaagagaat taggagagag gttaatgtta cttttttcca     5580

ttttggaaat aattttaatc aagtaactca aatgtgacaa aatttatttt tattttttgt     5640

ggttatattc ccaacaacat taaaaaatac tcgaggcata aatgtagttg tctcctactc     5700

tgcttctctt actatactca tacattttta atatggttta tcaatgattc atgtttccct     5760

caaatagtga tggtttacac ctgtcatgga aacaatccta gagagctcag agcaattaaa     5820

ccactattcc atgcttttaa gtagttttct ccaccttttt cttatgagtc tcactagatt     5880

gactgaggaa tgtatgtcta aattcctgga gaagatgata tggattggaa actgaaattc     5940

agagaaatgg agtgttcaat agataccacg aattgtgaac aaagggaaaa ttctatacaa     6000

ctcaatctaa gtcagtccac tttgacttcg tactgtcttt cacctttcca ttgttgcatc     6060

ttgaattttt taaaatgtct agaattcagg atgctagggg ctacttcttt aaaaaaaaaa     6120

aaaaaaaaga attcgtctga aaatgctcag gtttgtaaga atctaatctc acttacataa     6180

ctaagcactc cataataagt tttattaagt acaaagggag ccagaaaaaa tgacatttat     6240

ttcttctaga tcagaaaaat ttaaattaag ccctgccttg ctgtttagaa atatgtgggc     6300

attgttataa tttattcaat aaatttatgt tcctttgcct tcctgtggaa acagttttat     6360

cccactaaac taggaattag gggataaatc acaaacaaaa aaaaagttgc agcactgaaa     6420

aaaagtaatt tattgttttt gcaactggta tgtgaatttg tgtgataaaa ttatttattc     6480

ttatttaaca aaaatatgtt caaatttttc tatatttaaa atgttttgct gttgtcctac     6540

tttttaattt atgcttcatg tttgtgtata aagtacactt ttacactttg tgagtttaca     6600

taatatacag cactggttgc ttttgtattt ttttacagaa agctttctgt gtgaagcagg     6660

tgtatatgta tatattcctc atgtattctt attctgatac tatcattttt ctttccaagg     6720

aaattttaat ctgtcatgac caatagtgtt cattacttgt gcctatgata ataggttttt     6780

tacatcacat taacactatt ttttccaagt cacaaataag aaaaacactt attcaatgaa     6840

acaaggtgca agttttaaat ttgggtacac aaatagccta gaagcttcct acagacgcta     6900

agacacagcc aataatcaga tcctttcact tcatcgagaa acttggacaa gtcgatattg     6960

atgtattaga tgaaagttgt ctacacacaa cttctgaggg atacaaacga taataaaacc     7020

aaatgttgtc tgtttctcct ttagaaacac ctcctaaaat taatatcatt tagtctctag     7080

tgtctgtagg attctacaga tgagcacaaa tagattgggt ttgtataaca aatgctaata     7140

gtcataactg tttctacaaa tatggggtgt ccattaagag aatgtgatgt tttcctactg     7200

ctgttgaatc ccatggggtg attataggac ttgaaatagg cagagtcacc tctgatgaca     7260

tcagcttgcc tctgtgattt cacagtctga tcctggcaac aagacaaagc acccttggac     7320

acacagccaa tctctggttg tgatatttcc ccattgattc cttccttgtt aacaaggtca     7380

ttttaatggt tcaggtgagg acagcagcca gattcaaagt ccagaatttg tgctgttaca     7440

tagagttcac actgtcaaat aacattgaat ttaataatga tcaaattttt ctagtagtct     7500

ttggcagagt gtataatctc attggcatga ttggtgaata ttactaatct ctttataatg     7560

aaagatgctt tacaaatacc ttatatttgc taacatttca aaactactaa ataaatgaaa     7620

tagccatgtg tacagaaatg gtcatttaaa gctttaatag aaccaaattc aagacaatgt     7680

atcatttaga cacacagaaa aggaacttgt atgttttccc tattattttt ctcatttgcc     7740

aacaatctat agttttaggt tatcaaacag atagatcaac ttaactggct agtacattga     7800

aaaatcttcc taagaatcct ttgttagcat aatctataga gataatttct caaattatat     7860

catcatgatg catataaact ctataatgta taattgtgtt tcatttattt aatgtatgag     7920

aacatattga aatacaaaac catgcattag ccaaaaaatt ggaatacagg tagtgttcag     7980

atcagcaaaa cattcagtct ggtaaatgcc tgcctggggc tatgatatca ttctcaatgc     8040

aggttttatg gaaaaactaa aagaatatgt tgttagatga tgttggtttt gaaaaaaaaa     8100

agacattaac atacacatta gttagcccag ttaattgcat tctactaata tagttgcaca     8160

ttagcaataa ttttgctgtc tctggtcttt attttgtggc ttcaactaac tggaccatgt     8220

ggactgtaaa ggtcaaatgg aaaaaacgag cagtggcccc tcatcctgta aggtactgct     8280

acatcagagt gacctaaaag tctaacactg tgaggaaaac tgtgatttgt aggaaaaaaa     8340

aaaaaaacaa ataaaaaaca gggcatgctt tttaattttt ttccactttc ctttggcaca     8400

cccaatgaac aattctaatt tttattgagg tgctaacatc tttcgtgacc gactgtcaaa     8460

tgtggtattt ttgagttact atttttctac atgattttac agtttgcaag aaagacctct     8520

aagctttgtg tcacggtagg gcacaacttg atactcaaaa tttgaaaaat aagcacatcc     8580

aatgattgtt ttgaccaaca gtggtcagtg acgtaaactg catgtgcatc tgaggacatt     8640

taaggggtca ttaaaatttg aggagcatca ggccggagta gcagactttt agatgagtca     8700

tatttcagca ttcactaagt cctcagcatt ccattcaaac tgtcgtgtat atttggcctg     8760

attttttttc aagctttgca ataatttatg ttattggtaa acacttggtg actatatctc     8820

agccttttct ttaacaactc acaatatatt agaaacacgt ctacctatac tgagagtata     8880

tttacaatag aagaacatac tgtatgtgac tttgtaaagc tagacttttg attaagaaat     8940

atataatctc tggatgctat ttttgcatta tacactcagg cacaacgtaa accttgatgg     9000

ctcatcttgc tacaattacg agttgaaaaa cactacttac gtatttgtat gacctattag     9060

tcagaggaaa tcatacatat gctttgtaaa tagactttgc agataactaa atagactgaa     9120

gaaatatgtt gcatttgata gaagcaattg cataaatatt tggtttctat attagagtct     9180

gtgagtaaag tcaagtaata aacctaagta ggtataacag atttttaaac cttgaaactt     9240

gctttgatgg tagagaaaat cattgaagat ttacatactg tatataagat gtaaaatgta     9300

cgctgcttat taccctcaat tttccagaag caatggtata taatgcagtt gaaaaaccaa     9360

aaatcttgga aaactaagac gggtcttgtt taaaatgtct ctcagctttg gcaaccttca     9420

aatcttaatc aactatttaa agcattactg tgtcttgtag cctgcattcc acaacagctc     9480

tgttattcag gtaaaagact tgaactgagc cgtttgggac ctatactgta atattttcat     9540

tgaggaacaa tatcctattt tgtaaagcat ttccctatgt gtgactttaa actgtaaaat     9600

taaacactgc ttttgtgggt tcagtgggca taataaatat aaattgtaaa ctaggttaaa     9660

gta                                                                   9663


<210>  22
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro 
1               5                   10                  15      


Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly 
            20                  25                  30          


Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly 
        35                  40                  45              


Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu 
    50                  55                  60                  


Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu 
65                  70                  75                  80  


Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg 
                85                  90                  95      


Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly 
            100                 105                 110         


Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser 
        115                 120                 125             


His Cys Phe Tyr Arg Gly Thr Val Asp Gly Ser Pro Arg Ser Leu Ala 
    130                 135                 140                 


Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His 
145                 150                 155                 160 


Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu 
                165                 170                 175     


Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val 
            180                 185                 190         


Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser 
        195                 200                 205             


Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala 
    210                 215                 220                 


His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp 
225                 230                 235                 240 


Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp 
                245                 250                 255     


Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu 
            260                 265                 270         


Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln 
        275                 280                 285             


His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His 
    290                 295                 300                 


Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val 
305                 310                 315                 320 


Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr 
                325                 330                 335     


Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly 
            340                 345                 350         


Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu 
        355                 360                 365             


Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val 
    370                 375                 380                 


Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp 
385                 390                 395                 400 


Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu 
                405                 410                 415     


Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser 
            420                 425                 430         


Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala 
        435                 440                 445             


Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu 
    450                 455                 460                 


Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile 
465                 470                 475                 480 


Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln 
                485                 490                 495     


Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp 
            500                 505                 510         


Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val 
        515                 520                 525             


Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys 
    530                 535                 540                 


Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys 
545                 550                 555                 560 


Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp 
                565                 570                 575     


Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg 
            580                 585                 590         


His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly 
        595                 600                 605             


Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn 
    610                 615                 620                 


Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln 
625                 630                 635                 640 


Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr 
                645                 650                 655     


Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys 
            660                 665                 670         


Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr 
        675                 680                 685             


Glu Cys Arg Leu Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val 
    690                 695                 700                 


Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys 
705                 710                 715                 720 


Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly 
                725                 730                 735     


Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro 
            740                 745                 750         


Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln 
        755                 760                 765             


Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr 
    770                 775                 780                 


Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp 
785                 790                 795                 800 


Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp 
                805                 810                 815     


Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val 
            820                 825                 830         


Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser 
        835                 840                 845             


Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser 
    850                 855                 860                 


His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val 
865                 870                 875                 880 


Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His 
                885                 890                 895     


Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly 
            900                 905                 910         


Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys 
        915                 920                 925             


Lys Cys 
    930 


<210>  23
<211>  2255
<212>  DNA
<213>  Homo sapiens

<400>  23
cttgtggagc attcgggctt ggaaggaaag ctataggcta cccattcagc tcccctgtca       60

gagactcaag ctttgagaaa ggctagcaaa gagcaaggaa agagagaaaa caacaaagtg      120

gcgaggccct cagagtgaaa gcgtaaggtt cagtcagcct gctgcagctt tgcagacctc      180

agctgggcat ctccagactc ccctgaagga agagccttcc tcacccaaac ccacaaaaga      240

tgctgaaaaa gcctctctca gctgtgacct ggctctgcat tttcatcgtg gcctttgtca      300

gccacccagc gtggctgcag aagctctcta agcacaagac accagcacag ccacagctca      360

aagcggccaa ctgctgtgag gaggtgaagg agctcaaggc ccaagttgcc aaccttagca      420

gcctgctgag tgaactgaac aagaagcagg agagggactg ggtcagcgtg gtcatgcagg      480

tgatggagct ggagagcaac agcaagcgca tggagtcgcg gctcacagat gctgagagca      540

agtactccga gatgaacaac caaattgaca tcatgcagct gcaggcagca cagacggtca      600

ctcagacctc cgcagatgcc atctacgact gctcttccct ctaccagaag aactaccgca      660

tctctggagt gtataagctt cctcctgatg acttcctggg cagccctgaa ctggaggtgt      720

tctgtgacat ggagacttca ggcggaggct ggaccatcat ccagagacga aaaagtggcc      780

ttgtctcctt ctaccgggac tggaagcagt acaagcaggg ctttggcagc atccgtgggg      840

acttctggct ggggaacgaa cacatccacc ggctctccag acagccaacc cggctgcgtg      900

tagagatgga ggactgggag ggcaacctgc gctacgctga gtatagccac tttgttttgg      960

gcaatgaact caacagctat cgcctcttcc tggggaacta cactggcaat gtggggaacg     1020

acgccctcca gtatcataac aacacagcct tcagcaccaa ggacaaggac aatgacaact     1080

gcttggacaa gtgtgcacag ctccgcaaag gtggctactg gtacaactgc tgcacagact     1140

ccaacctcaa tggagtgtac taccgcctgg gtgagcacaa taagcacctg gatggcatca     1200

cctggtatgg ctggcatgga tctacctact ccctcaaacg ggtggagatg aaaatccgcc     1260

cagaagactt caagccttaa aaggaggctg ccgtggagca cggatacaga aactgagaca     1320

cgtggagact ggatgagggc agatgaggac aggaagagag tgttagaaag ggtaggactg     1380

agaaacagcc tataatctcc aaagaaagaa taagtctcca aggagcacaa aaaaatcata     1440

tgtaccaagg atgttacagt aaacaggatg aactatttaa acccactggg tcctgccaca     1500

tccttctcaa ggtggtagac tgagtggggt ctctctgccc aagatccctg acatagcagt     1560

agcttgtctt ttccacatga tttgtctgtg aaagaaaata attttgagat cgttttatct     1620

attttctcta cggcttaggc tatgtgaggg caaaacacaa atccctttgc taaaaagaac     1680

catattattt tgattctcaa aggataggcc tttgagtgtt agagaaagga gtgaaggagg     1740

caggtgggaa atggtatttc tatttttaaa tccagtgaaa ttatcttgag tctacacatt     1800

atttttaaaa cacaaaaatt gttcggctgg aactgaccca ggctggactt gcggggagga     1860

aactccaggg cactgcatct ggcgatcaga ctctgagcac tgcccctgct cgccttggtc     1920

atgtacagca ctgaaaggaa tgaagcacca gcaggaggtg gacagagtct ctcatggatg     1980

ccggcacaaa actgccttaa aatattcata gttaatacag gtatatctat ttttatttac     2040

tttgtaagaa acaagctcaa ggagcttcct tttaaatttt gtctgtagga aatggttgaa     2100

aactgaaggt agatggtgtt atagttaata ataaatgctg taaataagca tctcactttg     2160

taaaaataaa atattgtggt tttgttttaa acattcaacg tttcttttcc ttctacaata     2220

aacactttca aaatgtgaaa aaaaaaaaaa aaaaa                                2255


<210>  24
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Leu Lys Lys Pro Leu Ser Ala Val Thr Trp Leu Cys Ile Phe Ile 
1               5                   10                  15      


Val Ala Phe Val Ser His Pro Ala Trp Leu Gln Lys Leu Ser Lys His 
            20                  25                  30          


Lys Thr Pro Ala Gln Pro Gln Leu Lys Ala Ala Asn Cys Cys Glu Glu 
        35                  40                  45              


Val Lys Glu Leu Lys Ala Gln Val Ala Asn Leu Ser Ser Leu Leu Ser 
    50                  55                  60                  


Glu Leu Asn Lys Lys Gln Glu Arg Asp Trp Val Ser Val Val Met Gln 
65                  70                  75                  80  


Val Met Glu Leu Glu Ser Asn Ser Lys Arg Met Glu Ser Arg Leu Thr 
                85                  90                  95      


Asp Ala Glu Ser Lys Tyr Ser Glu Met Asn Asn Gln Ile Asp Ile Met 
            100                 105                 110         


Gln Leu Gln Ala Ala Gln Thr Val Thr Gln Thr Ser Ala Asp Ala Ile 
        115                 120                 125             


Tyr Asp Cys Ser Ser Leu Tyr Gln Lys Asn Tyr Arg Ile Ser Gly Val 
    130                 135                 140                 


Tyr Lys Leu Pro Pro Asp Asp Phe Leu Gly Ser Pro Glu Leu Glu Val 
145                 150                 155                 160 


Phe Cys Asp Met Glu Thr Ser Gly Gly Gly Trp Thr Ile Ile Gln Arg 
                165                 170                 175     


Arg Lys Ser Gly Leu Val Ser Phe Tyr Arg Asp Trp Lys Gln Tyr Lys 
            180                 185                 190         


Gln Gly Phe Gly Ser Ile Arg Gly Asp Phe Trp Leu Gly Asn Glu His 
        195                 200                 205             


Ile His Arg Leu Ser Arg Gln Pro Thr Arg Leu Arg Val Glu Met Glu 
    210                 215                 220                 


Asp Trp Glu Gly Asn Leu Arg Tyr Ala Glu Tyr Ser His Phe Val Leu 
225                 230                 235                 240 


Gly Asn Glu Leu Asn Ser Tyr Arg Leu Phe Leu Gly Asn Tyr Thr Gly 
                245                 250                 255     


Asn Val Gly Asn Asp Ala Leu Gln Tyr His Asn Asn Thr Ala Phe Ser 
            260                 265                 270         


Thr Lys Asp Lys Asp Asn Asp Asn Cys Leu Asp Lys Cys Ala Gln Leu 
        275                 280                 285             


Arg Lys Gly Gly Tyr Trp Tyr Asn Cys Cys Thr Asp Ser Asn Leu Asn 
    290                 295                 300                 


Gly Val Tyr Tyr Arg Leu Gly Glu His Asn Lys His Leu Asp Gly Ile 
305                 310                 315                 320 


Thr Trp Tyr Gly Trp His Gly Ser Thr Tyr Ser Leu Lys Arg Val Glu 
                325                 330                 335     


Met Lys Ile Arg Pro Glu Asp Phe Lys Pro 
            340                 345     


<210>  25
<211>  3572
<212>  DNA
<213>  Homo sapiens

<400>  25
gcctttctgg ggcctggggg atcctcttgc actggtgggt ggagagaagc gcctgcagcc       60

aaccagggtc aggctgtgct cacagtttcc tctggcggca tgtaaaggct ccacaaagga      120

gttgggagtt caaatgaggc tgctgcggac ggcctgagga tggaccccaa gccctggacc      180

tgccgagcgt ggcactgagg cagcggctga cgctactgtg agggaaagaa ggttgtgagc      240

agccccgcag gacccctggc cagccctggc cccagcctct gccggagccc tctgtggagg      300

cagagccagt ggagcccagt gaggcagggc tgcttggcag ccaccggcct gcaactcagg      360

aacccctcca gaggccatgg acaggctgcc ccgctgacgg ccagggtgaa gcatgtgagg      420

agccgccccg gagccaagca ggagggaaga ggctttcata gattctattc acaaagaata      480

accaccattt tgcaaggacc atgaggccac tgtgcgtgac atgctggtgg ctcggactgc      540

tggctgccat gggagctgtt gcaggccagg aggacggttt tgagggcact gaggagggct      600

cgccaagaga gttcatttac ctaaacaggt acaagcgggc gggcgagtcc caggacaagt      660

gcacctacac cttcattgtg ccccagcagc gggtcacggg tgccatctgc gtcaactcca      720

aggagcctga ggtgcttctg gagaaccgag tgcataagca ggagctagag ctgctcaaca      780

atgagctgct caagcagaag cggcagatcg agacgctgca gcagctggtg gaggtggacg      840

gcggcattgt gagcgaggtg aagctgctgc gcaaggagag ccgcaacatg aactcgcggg      900

tcacgcagct ctacatgcag ctcctgcacg agatcatccg caagcgggac aacgcgttgg      960

agctctccca gctggagaac aggatcctga accagacagc cgacatgctg cagctggcca     1020

gcaagtacaa ggacctggag cacaagtacc agcacctggc cacactggcc cacaaccaat     1080

cagagatcat cgcgcagctt gaggagcact gccagagggt gccctcggcc aggcccgtcc     1140

cccagccacc ccccgctgcc ccgccccggg tctaccaacc acccacctac aaccgcatca     1200

tcaaccagat ctctaccaac gagatccaga gtgaccagaa cctgaaggtg ctgccacccc     1260

ctctgcccac tatgcccact ctcaccagcc tcccatcttc caccgacaag ccgtcgggcc     1320

catggagaga ctgcctgcag gccctggagg atggccacga caccagctcc atctacctgg     1380

tgaagccgga gaacaccaac cgcctcatgc aggtgtggtg cgaccagaga cacgaccccg     1440

ggggctggac cgtcatccag agacgcctgg atggctctgt taacttcttc aggaactggg     1500

agacgtacaa gcaagggttt gggaacattg acggcgaata ctggctgggc ctggagaaca     1560

tttactggct gacgaaccaa ggcaactaca aactcctggt gaccatggag gactggtccg     1620

gccgcaaagt ctttgcagaa tacgccagtt tccgcctgga acctgagagc gagtattata     1680

agctgcggct ggggcgctac catggcaatg cgggtgactc ctttacatgg cacaacggca     1740

agcagttcac caccctggac agagatcatg atgtctacac aggaaactgt gcccactacc     1800

agaagggagg ctggtggtat aacgcctgtg cccactccaa cctcaacggg gtctggtacc     1860

gcgggggcca ttaccggagc cgctaccagg acggagtcta ctgggctgag ttccgaggag     1920

gctcttactc actcaagaaa gtggtgatga tgatccgacc gaaccccaac accttccact     1980

aagccagctc cccctcctga cctctcgtgg ccattgccag gagcccaccc tggtcacgct     2040

ggccacagca caaagaacaa ctcctcacca gttcatcctg aggctgggag gaccgggatg     2100

ctggattctg ttttccgaag tcactgcagc ggatgatgga actgaatcga tacggtgttt     2160

tctgtccctc ctactttcct tcacaccaga cagcccctca tgtctccagg acaggacagg     2220

actacagaca actctttctt taaataaatt aagtctctac aataaaaaca caactgcaaa     2280

gtaccttcat aatatacatg tgtatgagcc tcccttgtgc acgtatgtgt ataccacata     2340

tatatgcatt tagatataca tcacatgtga tatatctaga tccatatata ggtttgcctt     2400

agatacctaa atacacatat attcagttct cagatgttga agctgtcacc agcagctttg     2460

ctcttaggag aaaagcattt cattagtgtt gtattacttg agtctaaggg tagatcacag     2520

actgtgtggt ctcaactgaa aggatcaccc ttggcatctg tgtgcctgga ttcttccaga     2580

atgtctacaa tgctaatctc tcacatagag gttcccagct tcttaagaac cccttttggc     2640

acctaatcaa atttcaaaat ccctcccccc acattttcat acttttcccc attctcagga     2700

cttttcacca tccatcaccc acttatccct tcatttgaca ccattcatta agtgccttct     2760

gtgtgtcagt ccctggccac tcactgcagt tcaaggcccc ctttccgctc tgctgtactc     2820

ctcgcctacc tactccttgc cttttctgtc gcacagcccc ttctttccag gcgagattcc     2880

tcagcttctg agtaggaaac actccgggct ccaggtttct ggttgggaag ggaaggccag     2940

gccaaaagct ccaccggccg tatagataat gtactcgcag ttttgtatct tccattcata     3000

ctttaaccta caggtcattt gagtcttcac acaaataata acctatctgg ccaggagaat     3060

tatctcagaa cagaagtcat cagatcatca gagcccccag atggctacag accagagatt     3120

ccacgctctc aggctgacta gagtccgcat ctcatctcca aactacactt ccctggagaa     3180

caagtgccac aaaaatgaaa acaggccact tctcaggagt tgaataatca ggggtcaccg     3240

gaccccttgg ttgatgcact gcagcatggt ggctttctga gtcctgttgg ccaccaagtg     3300

tcagcctcag cactcccggg actattgcca agaaggggca agggatgagt caagaaggtg     3360

agacccttcc cggtgggcac gtgggccagg ctgtgtgaga tgttggatgt ttggtactgt     3420

ccatgtctgg gtgtgtgcct attacctcag catttctcac aaagtgtacc atgtagcatg     3480

ttttgtgtat ataaaaggga gggttttttt aaaaatatat tcccagatta tccttgtaat     3540

gacacgaatc tgcaataaaa gccatcagtg ct                                   3572


<210>  26
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Arg Pro Leu Cys Val Thr Cys Trp Trp Leu Gly Leu Leu Ala Ala 
1               5                   10                  15      


Met Gly Ala Val Ala Gly Gln Glu Asp Gly Phe Glu Gly Thr Glu Glu 
            20                  25                  30          


Gly Ser Pro Arg Glu Phe Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Gln Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val Leu Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Tyr Gln His Leu Ala Thr Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Ile Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ser Ala Arg Pro Val Pro Gln Pro Pro Pro Ala Ala Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Pro Leu Pro 
                245                 250                 255     


Thr Met Pro Thr Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Asp Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


<210>  27
<211>  5270
<212>  DNA
<213>  Homo sapiens

<400>  27
aaagtgattg attcggatac tgacactgta ggatctgggg agagaggaac aaaggaccgt       60

gaaagctgct ctgtaaaagc tgacacagcc ctcccaagtg agcaggactg ttcttcccac      120

tgcaatctga cagtttactg catgcctgga gagaacacag cagtaaaaac caggtttgct      180

actggaaaaa gaggaaagag aagactttca ttgacggacc cagccatggc agcgtagcag      240

ccctgcgttt tagacggcag cagctcggga ctctggacgt gtgtttgccc tcaagtttgc      300

taagctgctg gtttattact gaagaaagaa tgtggcagat tgttttcttt actctgagct      360

gtgatcttgt cttggccgca gcctataaca actttcggaa gagcatggac agcataggaa      420

agaagcaata tcaggtccag catgggtcct gcagctacac tttcctcctg ccagagatgg      480

acaactgccg ctcttcctcc agcccctacg tgtccaatgc tgtgcagagg gacgcgccgc      540

tcgaatacga tgactcggtg cagaggctgc aagtgctgga gaacatcatg gaaaacaaca      600

ctcagtggct aatgaagctt gagaattata tccaggacaa catgaagaaa gaaatggtag      660

agatacagca gaatgcagta cagaaccaga cggctgtgat gatagaaata gggacaaacc      720

tgttgaacca aacagcggag caaacgcgga agttaactga tgtggaagcc caagtattaa      780

atcagaccac gagacttgaa cttcagctct tggaacactc cctctcgaca aacaaattgg      840

aaaaacagat tttggaccag accagtgaaa taaacaaatt gcaagataag aacagtttcc      900

tagaaaagaa ggtgctagct atggaagaca agcacatcat ccaactacag tcaataaaag      960

aagagaaaga tcagctacag gtgttagtat ccaagcaaaa ttccatcatt gaagaactag     1020

aaaaaaaaat agtgactgcc acggtgaata attcagttct tcagaagcag caacatgatc     1080

tcatggagac agttaataac ttactgacta tgatgtccac atcaaactca gctaaggacc     1140

ccactgttgc taaagaagaa caaatcagct tcagagactg tgctgaagta ttcaaatcag     1200

gacacaccac gaatggcatc tacacgttaa cattccctaa ttctacagaa gagatcaagg     1260

cctactgtga catggaagct ggaggaggcg ggtggacaat tattcagcga cgtgaggatg     1320

gcagcgttga ttttcagagg acttggaaag aatataaagt gggatttggt aacccttcag     1380

gagaatattg gctgggaaat gagtttgttt cgcaactgac taatcagcaa cgctatgtgc     1440

ttaaaataca ccttaaagac tgggaaggga atgaggctta ctcattgtat gaacatttct     1500

atctctcaag tgaagaactc aattatagga ttcaccttaa aggacttaca gggacagccg     1560

gcaaaataag cagcatcagc caaccaggaa atgattttag cacaaaggat ggagacaacg     1620

acaaatgtat ttgcaaatgt tcacaaatgc taacaggagg ctggtggttt gatgcatgtg     1680

gtccttccaa cttgaacgga atgtactatc cacagaggca gaacacaaat aagttcaacg     1740

gcattaaatg gtactactgg aaaggctcag gctattcgct caaggccaca accatgatga     1800

tccgaccagc agatttctaa acatcccagt ccacctgagg aactgtctcg aactattttc     1860

aaagacttaa gcccagtgca ctgaaagtca cggctgcgca ctgtgtcctc ttccaccaca     1920

gagggcgtgt gctcggtgct gacgggaccc acatgctcca gattagagcc tgtaaacttt     1980

atcacttaaa cttgcatcac ttaacggacc aaagcaagac cctaaacatc cataattgtg     2040

attagacaga acacctatgc aaagatgaac ccgaggctga gaatcagact gacagtttac     2100

agacgctgct gtcacaacca agaatgttat gtgcaagttt atcagtaaat aactggaaaa     2160

cagaacactt atgttataca atacagatca tcttggaact gcattcttct gagcactgtt     2220

tatacactgt gtaaataccc atatgtcctg aattcaccat cactatcaca attaaaagga     2280

agaaaaaaac tctctaagcc ataaaaagac atattcaggg atattctgag aaggggttac     2340

tagaagttta atatttggaa aaacagttag tgcattttta ctccatctct taggtgcttt     2400

aaatttttat ttcaaaaaca gcgtatttac atttatgttg acagcttagt tataagttaa     2460

tgctcaaata cgtatttcaa atttatatgg tagaaacttc cagaatctct gaaattatca     2520

acagaaacgt gccattttag tttatatgca gaccgtacta tttttttctg cctgattgtt     2580

aaatatgaag gtatttttag taattaaata taacttatta ggggatatgc ctatgtttaa     2640

cttttatgat aatatttaca attttataat ttgtttccaa aagacctaat tgtgccttgt     2700

gataaggaaa cttcttactt ttaatgatga ggaaaattat acatttcatt ctatgacaaa     2760

gaaactttac tatcttctca ctattctaaa acagaggtct gttttctttc ctagtaagat     2820

atatttttat agaactagac tacaatttaa tttctggttg agaaaagcct tctatttaag     2880

aaatttacaa agctatatgt ctcaagattc acccttaaat ttacttaagg aaaaaaataa     2940

ttgacactag taagtttttt tatgtcaatc agcaaactga aaaaaaaaaa agggtttcaa     3000

agtgcaaaaa caaaatctga tgttcataat atatttaaat atttaccaaa aatttgagaa     3060

cacagggctg ggcgcagtgg ctcacaccta taatcccagt acattggtag gcaaggtggg     3120

cagatcacct gaggtcagga gttcaagacc agcctggaca acatggtgaa accctgtctc     3180

tactaaataa tacaaaaatt agccaggcgt gctggcgggc acctgtaatc ccagctactc     3240

gggaggctga ggcagggaga attgcttgca ccagggaggt agaggttgca gtgagccaag     3300

atcgcaccac tgcactccag ccggggcaac agagcaagac tccatctcaa aaaaaaaaaa     3360

aaaaaaagaa agaaaagaaa atttgagaac acagctttat actcgggact acaaaaccat     3420

aaactcctgg agttttaact ccttttgaaa ttttcatagt acaattaata ctaatgaaca     3480

tttgtgtaaa gctttataat ttaaaggcaa tttctcatat attcttttct gaatcatttg     3540

caaggaagtt cagagtccag tctgtaacta gcatctacta tatgtctgtc ttcaccttac     3600

agtgttctac cattattttt tctttattcc atttcaaaat ctaatttatt ttaccccaac     3660

ttctccccac cacttgacgt agttttagaa cacacaggtg ttgctacata tttggagtca     3720

atgatggact ctggcaaagt caaggctctg ttttatttcc accaaggtgc acttttccaa     3780

caactattta actagttaag aacctcccta tcttagaact gtatctactt tatatttaag     3840

aaggttttat gaattcaaca acggtatcat ggccttgtat caagttgaaa aacaactgaa     3900

aataagaaaa tttcacagcc tcgaaagaca acaacaagtt tctaggatat ctcaatgaca     3960

agagtgatgg atacttaggt agggaaacgc taatgcagga aaaactggca acaacacaat     4020

ttatatcaat tctctttgta ggcaggtgat aaaaaattca aggacaaatc tcattatgtc     4080

attgtgcatc atatataatc tcttatgagc gagaatgggg ggaatttgtg tttttacttt     4140

acacttcaat tccttacacg gtatttcaaa caaacagttt tgctgagagg agcttttgtc     4200

tctccttaag aaaatgttta taaagctgaa aggaaatcaa acagtaatct taaaaatgaa     4260

aacaaaacaa cccaacaacc tagataacta cagtgatcag ggagcacagt tcaactcctt     4320

gttatgtttt agtcatatgg cctactcaaa cagctaaata acaacaccag tggcagataa     4380

aaatcaccat ttatctttca gctattaatc ttttgaatga ataaactgtg acaaacaaat     4440

taacattttt gaacatgaaa ggcaacttct gcacaatcct gtatccaagc aaactttaaa     4500

ttatccactt aattattact taatcttaaa aaaaattaga acccagaact tttcaatgaa     4560

gcatttgaaa gttgaagtgg aatttaggaa agccataaaa atataaatac tgttatcaca     4620

gcaccagcaa gccataatct ttatacctat cagttctatt tctattaaca gtaaaaacat     4680

taagcaagat ataagactac ctgcccaaga attcagtctt ttttcatttt tgtttttctc     4740

agttctgagg atgttaatcg tcaaattttc tttggactgc attcctcact actttttgca     4800

caatggtctc acgttctcac atttgttctc gcgaataaat tgataaaagg tgttaagttc     4860

tgtgaatgtc tttttaatta tgggcataat tgtgcttgac tggataaaaa cttaagtcca     4920

cccttatgtt tataataatt tcttgagaac agcaaactgc atttaccatc gtaaaacaac     4980

atctgactta cgggagctgc agggaagtgg tgagacagtt cgaacggctc ctcagaaatc     5040

cagtgaccca attctaaaga ccatagcacc tgcaagtgac acaacaagca gatttattat     5100

acatttatta gccttagcag gcaataaacc aagaatcact ttgaagacac agcaaaaagt     5160

gatacactcc gcagatctga aatagatgtg ttctcagaca acaaagtccc ttcagaatct     5220

tcatgttgca taaatgttat gaatattaat aaaaagttga ttgagaaaaa                5270


<210>  28
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Thr Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Thr Asn Leu Leu Asn Gln Thr Ala Glu Gln Thr Arg Lys Leu Thr Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Thr Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn 
                245                 250                 255     


Asn Leu Leu Thr Met Met Ser Thr Ser Asn Ser Ala Lys Asp Pro Thr 
            260                 265                 270         


Val Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe 
        275                 280                 285             


Lys Ser Gly His Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn 
    290                 295                 300                 


Ser Thr Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly 
305                 310                 315                 320 


Gly Trp Thr Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln 
                325                 330                 335     


Arg Thr Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu 
            340                 345                 350         


Tyr Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg 
        355                 360                 365             


Tyr Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr 
    370                 375                 380                 


Ser Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg 
385                 390                 395                 400 


Ile His Leu Lys Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile 
                405                 410                 415     


Ser Gln Pro Gly Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys 
            420                 425                 430         


Cys Ile Cys Lys Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp 
        435                 440                 445             


Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln 
    450                 455                 460                 


Asn Thr Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser 
465                 470                 475                 480 


Gly Tyr Ser Leu Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
                485                 490                 495     


<210>  29
<211>  1726
<212>  DNA
<213>  Homo sapiens

<400>  29
cttggcttct ggccccctta tctgcccccg ccccacgcgc cctggcagca ccatgagccg       60

ccagcttctg cctgtactgc tgctgctgct gctcagggct tcgtgcccat ggggtcagga      120

acagggagcg aggagcccct cggaggagcc tccagaggag gaaatcccca aggaggatgg      180

gatcttggtg ctgagccgcc acaccctggg cctggccctg cgggagcacc ctgccctgct      240

ggtggaattc tatgccccgt ggtgtgggca ctgccaggcc ctggcccccg agtacagcaa      300

ggcagctgcc gtgctcgcgg ccgagtcaat ggtggtcacg ctggccaagg tggatgggcc      360

cgcgcagcgc gagctggctg aggagtttgg tgtgacggag taccctacgc tcaagttctt      420

ccgcaatggg aaccgcacgc acccggagga gtacacagga ccacgggacg ctgagggcat      480

tgccgagtgg ctgcgacggc gggtggggcc cagtgccatg cggctggagg acgaggcggc      540

cgcccaggcg ctgatcggtg gccgggacct agtggtcatt ggcttcttcc aggacctgca      600

ggacgaggac gtggccacct tcttggcctt ggcccaggac gccctggaca tgacctttgg      660

cctcacagac cggccgcggc tctttcagca gtttggcctc accaaggaca ctgtggttct      720

cttcaagaag tttgatgagg ggcgggcaga cttccccgtg gacgaggagc ttggcctgga      780

cctgggggat ctgtcgcgct tcctggtcac acacagcatg cgcctggtca cggagttcaa      840

cagccagacg tctgccaaga tcttcgcggc caggatcctc aaccacctgc tgctgtttgt      900

caaccagacg ctggctgcgc accgggagct cctagcgggc tttggggagg cagctccccg      960

cttccggggg caggtgctgt tcgtggtggt ggacgtggcg gccgacaatg agcacgtgct     1020

gcagtacttt ggactcaagg ctgaggcagc ccccactctg cgcttggtca accttgaaac     1080

cactaagaag tatgcgcctg tggatggggg ccctgtcacc gcagcgtcca tcactgcttt     1140

ctgccatgca gtcctcaacg gccaagtcaa gccctatctc ctgagccagg agataccccc     1200

tgattgggat cagcggccag ttaagaccct cgtgggcaag aattttgagc aggtggcttt     1260

tgacgaaacc aagaatgtgt ttgtcaagtt ctatgccccg tggtgcaccc actgcaagga     1320

gatggcccct gcctgggagg cattggctga gaagtaccaa gaccacgagg acatcatcat     1380

tgctgagctg gatgccacgg ccaacgagct ggatgccttc gctgtgcacg gcttccctac     1440

tctcaagtac ttcccagcag ggccaggtcg gaaggtgatt gaatacaaaa gcaccaggga     1500

cctggagact ttctccaagt tcctggacaa cgggggcgtg ctgcccacgg aggagccccc     1560

ggaggagcca gcagccccgt tcccggagcc accggccaac tccactatgg ggtccaagga     1620

ggaactgtag ctgcccccgt gtcacccccg ccatcactgc tggacaggag ccaccccctt     1680

gggtaccaga gggagctgtg cattgtgaat aaagagtgag cttggt                    1726


<210>  30
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Arg Gln Leu Leu Pro Val Leu Leu Leu Leu Leu Leu Arg Ala 
1               5                   10                  15      


Ser Cys Pro Trp Gly Gln Glu Gln Gly Ala Arg Ser Pro Ser Glu Glu 
            20                  25                  30          


Pro Pro Glu Glu Glu Ile Pro Lys Glu Asp Gly Ile Leu Val Leu Ser 
        35                  40                  45              


Arg His Thr Leu Gly Leu Ala Leu Arg Glu His Pro Ala Leu Leu Val 
    50                  55                  60                  


Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln Ala Leu Ala Pro Glu 
65                  70                  75                  80  


Tyr Ser Lys Ala Ala Ala Val Leu Ala Ala Glu Ser Met Val Val Thr 
                85                  90                  95      


Leu Ala Lys Val Asp Gly Pro Ala Gln Arg Glu Leu Ala Glu Glu Phe 
            100                 105                 110         


Gly Val Thr Glu Tyr Pro Thr Leu Lys Phe Phe Arg Asn Gly Asn Arg 
        115                 120                 125             


Thr His Pro Glu Glu Tyr Thr Gly Pro Arg Asp Ala Glu Gly Ile Ala 
    130                 135                 140                 


Glu Trp Leu Arg Arg Arg Val Gly Pro Ser Ala Met Arg Leu Glu Asp 
145                 150                 155                 160 


Glu Ala Ala Ala Gln Ala Leu Ile Gly Gly Arg Asp Leu Val Val Ile 
                165                 170                 175     


Gly Phe Phe Gln Asp Leu Gln Asp Glu Asp Val Ala Thr Phe Leu Ala 
            180                 185                 190         


Leu Ala Gln Asp Ala Leu Asp Met Thr Phe Gly Leu Thr Asp Arg Pro 
        195                 200                 205             


Arg Leu Phe Gln Gln Phe Gly Leu Thr Lys Asp Thr Val Val Leu Phe 
    210                 215                 220                 


Lys Lys Phe Asp Glu Gly Arg Ala Asp Phe Pro Val Asp Glu Glu Leu 
225                 230                 235                 240 


Gly Leu Asp Leu Gly Asp Leu Ser Arg Phe Leu Val Thr His Ser Met 
                245                 250                 255     


Arg Leu Val Thr Glu Phe Asn Ser Gln Thr Ser Ala Lys Ile Phe Ala 
            260                 265                 270         


Ala Arg Ile Leu Asn His Leu Leu Leu Phe Val Asn Gln Thr Leu Ala 
        275                 280                 285             


Ala His Arg Glu Leu Leu Ala Gly Phe Gly Glu Ala Ala Pro Arg Phe 
    290                 295                 300                 


Arg Gly Gln Val Leu Phe Val Val Val Asp Val Ala Ala Asp Asn Glu 
305                 310                 315                 320 


His Val Leu Gln Tyr Phe Gly Leu Lys Ala Glu Ala Ala Pro Thr Leu 
                325                 330                 335     


Arg Leu Val Asn Leu Glu Thr Thr Lys Lys Tyr Ala Pro Val Asp Gly 
            340                 345                 350         


Gly Pro Val Thr Ala Ala Ser Ile Thr Ala Phe Cys His Ala Val Leu 
        355                 360                 365             


Asn Gly Gln Val Lys Pro Tyr Leu Leu Ser Gln Glu Ile Pro Pro Asp 
    370                 375                 380                 


Trp Asp Gln Arg Pro Val Lys Thr Leu Val Gly Lys Asn Phe Glu Gln 
385                 390                 395                 400 


Val Ala Phe Asp Glu Thr Lys Asn Val Phe Val Lys Phe Tyr Ala Pro 
                405                 410                 415     


Trp Cys Thr His Cys Lys Glu Met Ala Pro Ala Trp Glu Ala Leu Ala 
            420                 425                 430         


Glu Lys Tyr Gln Asp His Glu Asp Ile Ile Ile Ala Glu Leu Asp Ala 
        435                 440                 445             


Thr Ala Asn Glu Leu Asp Ala Phe Ala Val His Gly Phe Pro Thr Leu 
    450                 455                 460                 


Lys Tyr Phe Pro Ala Gly Pro Gly Arg Lys Val Ile Glu Tyr Lys Ser 
465                 470                 475                 480 


Thr Arg Asp Leu Glu Thr Phe Ser Lys Phe Leu Asp Asn Gly Gly Val 
                485                 490                 495     


Leu Pro Thr Glu Glu Pro Pro Glu Glu Pro Ala Ala Pro Phe Pro Glu 
            500                 505                 510         


Pro Pro Ala Asn Ser Thr Met Gly Ser Lys Glu Glu Leu 
        515                 520                 525 


<210>  31
<211>  1873
<212>  DNA
<213>  Homo sapiens

<400>  31
ctgcgcatgc tttggcagac gtggcaccgg gaactcggag gcggggagcg gctgggaagt       60

ggccgtggtg gttggccgcg gtggagctag caggcgggcg ggcgggagcg ggcgccggag      120

tggagaaagg agccagcggt gggcagcgct gctgggatgg cgcgggccgg gccggcgtgg      180

ctgctgctgg caatctgggt ggtcctgcca tcatggctgt cctctgcaaa ggtctcctcg      240

ctcattgaga gaatctctga ccccaaggac ttgaaaaaac tgctcagaac ccggaataat      300

gtactggtgc tttactccaa atctgaggtg gcagctgaaa atcatctcag gttactgtcc      360

acagtggccc aggcggtgaa aggacaaggg accatctgct gggtggactg tggtgatgca      420

gagagtagaa aattgtgcaa gaagatgaaa gttgacctga gcccgaagga caaaaaggtt      480

gaattattcc attaccagga tggtgcattt catactgaat ataaccgagc tgtgacattt      540

aagtccatag tggccttttt gaaggatcca aaagggcccc cactgtggga ggaagatcct      600

ggagccaaag atgttgtcca ccttgacagt gaaaaggact tcagacggct cctgaagaag      660

gaagagaagc cgctcctgat catgttttat gccccctggt gcagcatgtg caagaggatg      720

atgccgcatt tccagaaggc tgcgactcag ctgcgaggcc acgccgtgct ggccgggatg      780

aatgtctact cctctgaatt tgaaaacatc aaggaggagt acagcgtgcg cggcttcccc      840

accatctgct attttgagaa aggacggttc ttgttccagt atgacaacta tgggtccaca      900

gctgaggaca ttgtggagtg gctgaagaat ccgcagccgc cacagcccca ggtccctgag      960

actccctggg cagatgaggg cggctccgtt tatcacctga ccgatgaaga ctttgaccag     1020

tttgtgaagg aacactcctc tgtcctcgtc atgttccacg ccccatggtg tggccactgt     1080

aagaaaatga agccggagtt tgagaaggca gcagaagccc tccatggaga agcggatagc     1140

tctggtgtcc ttgcagctgt cgatgccact gtcaacaagg ccctggcaga aagattccac     1200

atctcagagt ttcctacgtt gaagtatttt aagaatggag agaaatacgc agtgcctgtg     1260

ctcaggacaa agaagaagtt tctcgagtgg atgcaaaacc ctgaggcccc cccgccccca     1320

gagcccacgt gggaagagca gcagacaagc gtgttgcacc tggtggggga caacttccgg     1380

gagaccctga agaagaagaa acacaccttg gtcatgttct acgccccttg gtgcccacac     1440

tgtaagaagg tcattccgca ctttactgct actgctgatg ccttcaaaga tgaccgaaag     1500

attgcctgtg ccgctgttga ctgtgtcaaa gacaagaacc aagacctgtg ccagcaggag     1560

gcggtcaagg gctaccccac tttccactac taccactatg ggaagttcgc agaaaagtat     1620

gacagcgacc gcacagaatt gggatttacc aattatattc gagccctccg ggagggagac     1680

catgaaagac tagggaaaaa gaaggaagag ttataattcc tgcctcagaa aaagcttttc     1740

cattacactg tgaatgatac ctgttttgtt gtttctgaat ttccacatgt tctgaagaca     1800

aattttttat agccgcttat ggccattttg tacaattttg aaataaaatt aaaccattta     1860

ttaaaaaaaa aaa                                                        1873


<210>  32
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Arg Ala Gly Pro Ala Trp Leu Leu Leu Ala Ile Trp Val Val 
1               5                   10                  15      


Leu Pro Ser Trp Leu Ser Ser Ala Lys Val Ser Ser Leu Ile Glu Arg 
            20                  25                  30          


Ile Ser Asp Pro Lys Asp Leu Lys Lys Leu Leu Arg Thr Arg Asn Asn 
        35                  40                  45              


Val Leu Val Leu Tyr Ser Lys Ser Glu Val Ala Ala Glu Asn His Leu 
    50                  55                  60                  


Arg Leu Leu Ser Thr Val Ala Gln Ala Val Lys Gly Gln Gly Thr Ile 
65                  70                  75                  80  


Cys Trp Val Asp Cys Gly Asp Ala Glu Ser Arg Lys Leu Cys Lys Lys 
                85                  90                  95      


Met Lys Val Asp Leu Ser Pro Lys Asp Lys Lys Val Glu Leu Phe His 
            100                 105                 110         


Tyr Gln Asp Gly Ala Phe His Thr Glu Tyr Asn Arg Ala Val Thr Phe 
        115                 120                 125             


Lys Ser Ile Val Ala Phe Leu Lys Asp Pro Lys Gly Pro Pro Leu Trp 
    130                 135                 140                 


Glu Glu Asp Pro Gly Ala Lys Asp Val Val His Leu Asp Ser Glu Lys 
145                 150                 155                 160 


Asp Phe Arg Arg Leu Leu Lys Lys Glu Glu Lys Pro Leu Leu Ile Met 
                165                 170                 175     


Phe Tyr Ala Pro Trp Cys Ser Met Cys Lys Arg Met Met Pro His Phe 
            180                 185                 190         


Gln Lys Ala Ala Thr Gln Leu Arg Gly His Ala Val Leu Ala Gly Met 
        195                 200                 205             


Asn Val Tyr Ser Ser Glu Phe Glu Asn Ile Lys Glu Glu Tyr Ser Val 
    210                 215                 220                 


Arg Gly Phe Pro Thr Ile Cys Tyr Phe Glu Lys Gly Arg Phe Leu Phe 
225                 230                 235                 240 


Gln Tyr Asp Asn Tyr Gly Ser Thr Ala Glu Asp Ile Val Glu Trp Leu 
                245                 250                 255     


Lys Asn Pro Gln Pro Pro Gln Pro Gln Val Pro Glu Thr Pro Trp Ala 
            260                 265                 270         


Asp Glu Gly Gly Ser Val Tyr His Leu Thr Asp Glu Asp Phe Asp Gln 
        275                 280                 285             


Phe Val Lys Glu His Ser Ser Val Leu Val Met Phe His Ala Pro Trp 
    290                 295                 300                 


Cys Gly His Cys Lys Lys Met Lys Pro Glu Phe Glu Lys Ala Ala Glu 
305                 310                 315                 320 


Ala Leu His Gly Glu Ala Asp Ser Ser Gly Val Leu Ala Ala Val Asp 
                325                 330                 335     


Ala Thr Val Asn Lys Ala Leu Ala Glu Arg Phe His Ile Ser Glu Phe 
            340                 345                 350         


Pro Thr Leu Lys Tyr Phe Lys Asn Gly Glu Lys Tyr Ala Val Pro Val 
        355                 360                 365             


Leu Arg Thr Lys Lys Lys Phe Leu Glu Trp Met Gln Asn Pro Glu Ala 
    370                 375                 380                 


Pro Pro Pro Pro Glu Pro Thr Trp Glu Glu Gln Gln Thr Ser Val Leu 
385                 390                 395                 400 


His Leu Val Gly Asp Asn Phe Arg Glu Thr Leu Lys Lys Lys Lys His 
                405                 410                 415     


Thr Leu Val Met Phe Tyr Ala Pro Trp Cys Pro His Cys Lys Lys Val 
            420                 425                 430         


Ile Pro His Phe Thr Ala Thr Ala Asp Ala Phe Lys Asp Asp Arg Lys 
        435                 440                 445             


Ile Ala Cys Ala Ala Val Asp Cys Val Lys Asp Lys Asn Gln Asp Leu 
    450                 455                 460                 


Cys Gln Gln Glu Ala Val Lys Gly Tyr Pro Thr Phe His Tyr Tyr His 
465                 470                 475                 480 


Tyr Gly Lys Phe Ala Glu Lys Tyr Asp Ser Asp Arg Thr Glu Leu Gly 
                485                 490                 495     


Phe Thr Asn Tyr Ile Arg Ala Leu Arg Glu Gly Asp His Glu Arg Leu 
            500                 505                 510         


Gly Lys Lys Lys Glu Glu Leu 
        515                 


<210>  33
<211>  1593
<212>  DNA
<213>  Homo sapiens

<400>  33
gcggtgccct tgcggcgcag ctggggtcgc ggccctgctc cccgcgcttt cttaaggccc       60

gcgggcggcg caggagcggc actcgtggct gtggtggctt cggcagcggc ttcagcagat      120

cggcggcatc agcggtagca ccagcactag cagcatgttg agccgggcag tgtgcggcac      180

cagcaggcag ctggctccgg ttttggggta tctgggctcc aggcagaagc acagcctccc      240

cgacctgccc tacgactacg gcgccctgga acctcacatc aacgcgcaga tcatgcagct      300

gcaccacagc aagcaccacg cggcctacgt gaacaacctg aacgtcaccg aggagaagta      360

ccaggaggcg ttggccaagg gagatgttac agcccagata gctcttcagc ctgcactgaa      420

gttcaatggt ggtggtcata tcaatcatag cattttctgg acaaacctca gccctaacgg      480

tggtggagaa cccaaagggg agttgctgga agccatcaaa cgtgactttg gttcctttga      540

caagtttaag gagaagctga cggctgcatc tgttggtgtc caaggctcag gttggggttg      600

gcttggtttc aataaggaac ggggacactt acaaattgct gcttgtccaa atcaggatcc      660

actgcaagga acaacaggcc ttattccact gctggggatt gatgtgtggg agcacgctta      720

ctaccttcag tataaaaatg tcaggcctga ttatctaaaa gctatttgga atgtaatcaa      780

ctgggagaat gtaactgaaa gatacatggc ttgcaaaaag taaaccacga tcgttatgct      840

gagtatgtta agctctttat gactgttttt gtagtggtat agagtactgc agaatacagt      900

aagctgctct attgtagcat ttcttgatgt tgcttagtca cttatttcat aaacaactta      960

atgttctgaa taatttctta ctaaacattt tgttattggg caagtgattg aaaatagtaa     1020

atgctttgtg tgattgaatc tgattggaca ttttcttcag agagctaaat tacaattgtc     1080

atttataaaa ccatcaaaaa tattccatcc atatactttg gggacttgta gggatgcctt     1140

tctagtccta ttctattgca gttatagaaa atctagtctt ttgccccagt tacttaaaaa     1200

taaaatatta acactttccc aagggaaaca ctcggctttc tatagaaaat tgcacttttt     1260

gtcgagtaat cctctgcagt gatacttctg gtagatgtca cccagtggtt tttgttaggt     1320

caaatgttcc tgtatagttt ttgcaaatag agctgtatac tgtttaaatg tagcaggtga     1380

actgaactgg ggtttgctca cctgcacagt aaaggcaaac ttcaacagca aaactgcaaa     1440

aaggtggttt ttgcagtagg agaaaggagg atgtttattt gcagggcgcc aagcaaggag     1500

aattgggcag ctcatgcttg agacccaatc tccatgatga cctacaagct agagtattta     1560

aaggcagtgg taaatttcag gaaagcagaa gtt                                  1593


<210>  34
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Val 
1               5                   10                  15      


Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro 
            20                  25                  30          


Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln 
        35                  40                  45              


Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val 
    50                  55                  60                  


Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Asp Val Thr Ala 
65                  70                  75                  80  


Gln Ile Ala Leu Gln Pro Ala Leu Lys Phe Asn Gly Gly Gly His Ile 
                85                  90                  95      


Asn His Ser Ile Phe Trp Thr Asn Leu Ser Pro Asn Gly Gly Gly Glu 
            100                 105                 110         


Pro Lys Gly Glu Leu Leu Glu Ala Ile Lys Arg Asp Phe Gly Ser Phe 
        115                 120                 125             


Asp Lys Phe Lys Glu Lys Leu Thr Ala Ala Ser Val Gly Val Gln Gly 
    130                 135                 140                 


Ser Gly Trp Gly Trp Leu Gly Phe Asn Lys Glu Arg Gly His Leu Gln 
145                 150                 155                 160 


Ile Ala Ala Cys Pro Asn Gln Asp Pro Leu Gln Gly Thr Thr Gly Leu 
                165                 170                 175     


Ile Pro Leu Leu Gly Ile Asp Val Trp Glu His Ala Tyr Tyr Leu Gln 
            180                 185                 190         


Tyr Lys Asn Val Arg Pro Asp Tyr Leu Lys Ala Ile Trp Asn Val Ile 
        195                 200                 205             


Asn Trp Glu Asn Val Thr Glu Arg Tyr Met Ala Cys Lys Lys 
    210                 215                 220         


<210>  35
<211>  1546
<212>  DNA
<213>  Homo sapiens

<400>  35
ggggaggtct ggcctgcttt tcctccctga actggcccaa tgactggctc cctcacgctg       60

accactcctc tgggctggcc tcctgcactc gcgctaacag cccaggctcc agggacagcc      120

tgcgttcctg ggctggctgg gtgcagctct cttttcagga gagaaagctc tcttggagga      180

gctggaaagg tgcccgactc cagccatgct ggcgctactg tgttcctgcc tgctcctggc      240

agccggtgcc tcggacgcct ggacgggcga ggactcggcg gagcccaact ctgactcggc      300

ggagtggatc cgagacatgt acgccaaggt cacggagatc tggcaggagg tcatgcagcg      360

gcgggacgac gacggcgcgc tccacgccgc ctgccaggtg cagccgtcgg ccacgctgga      420

cgccgcgcag ccccgggtga ccggcgtcgt cctcttccgg cagcttgcgc cccgcgccaa      480

gctcgacgcc ttcttcgccc tggagggctt cccgaccgag ccgaacagct ccagccgcgc      540

catccacgtg caccagttcg gggacctgag ccagggctgc gagtccaccg ggccccacta      600

caacccgctg gccgtgccgc acccgcagca cccgggcgac ttcggcaact tcgcggtccg      660

cgacggcagc ctctggaggt accgcgccgg cctggccgcc tcgctcgcgg gcccgcactc      720

catcgtgggc cgggccgtgg tcgtccacgc tggcgaggac gacctgggcc gcggcggcaa      780

ccaggccagc gtggagaacg ggaacgcggg ccggcggctg gcctgctgcg tggtgggcgt      840

gtgcgggccc gggctctggg agcgccaggc gcgggagcac tcagagcgca agaagcggcg      900

gcgcgagagc gagtgcaagg ccgcctgagc gcggccccca cccggcggcg gccagggacc      960

cccgaggccc ccctctgcct ttgagcttct cctctgctcc aacagacacc ctccactctg     1020

aggtctcacc ttcgcctttg ctgaagtctc cccgcagccc tctccaccca gaggtctccc     1080

tataccgaga cccaccatcc ttccatcctg aggaccgccc caaccctcgg agccccccac     1140

tcagtaggtc tgaaggcctc catttgtacc gaaacacccc gctcacgctg acagcctcct     1200

aggctccctg aggtaccttt ccacccagac cctccttccc caccccataa gccctgagac     1260

tcccgccttt gacctgacga tcttccccct tcccgccttc aggttcctcc taggcgctca     1320

gaggccgctc tggggggttg cctcgagtcc ccccacccct ccccacccac caccgctccc     1380

gcggcaagcc agcccgtgca acggaagcca ggccaactgc cccgcgtctt cagctgtttc     1440

gcatccaccg ccaccccact gagagctgct cctttggggg aatgtttggc aacctttgtg     1500

ttacagatta aaaattcagc aattcagtaa aaaaaaaaaa aaaaaa                    1546


<210>  36
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser 
1               5                   10                  15      


Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala 
            20                  25                  30          


Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu 
        35                  40                  45              


Val Met Gln Arg Arg Asp Asp Asp Gly Ala Leu His Ala Ala Cys Gln 
    50                  55                  60                  


Val Gln Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly 
65                  70                  75                  80  


Val Val Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe 
                85                  90                  95      


Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala 
            100                 105                 110         


Ile His Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr 
        115                 120                 125             


Gly Pro His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly 
    130                 135                 140                 


Asp Phe Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg 
145                 150                 155                 160 


Ala Gly Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg 
                165                 170                 175     


Ala Val Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn 
            180                 185                 190         


Gln Ala Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys 
        195                 200                 205             


Val Val Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu 
    210                 215                 220                 


His Ser Glu Arg Lys Lys Arg Arg Arg Glu Ser Glu Cys Lys Ala Ala 
225                 230                 235                 240 


<210>  37
<211>  1327
<212>  DNA
<213>  Homo sapiens

<400>  37
gcggccgcac cccccggccg ggccgtgctt ctgcccctac aaggtttggg ccgaggtggg       60

ggagggtcct ggttgccggc cccgcccggt ccctccccgc cttttaggcg cccgcgtggc      120

cgggacgtcc cagtcccgct ccgtcctcct cgcctgccac cggtgcaccc agtccgctca      180

cccagcccag tccgtccggt cctcaccgcc tgccggccgg cccacccccc accgcagcca      240

tggacgccat caagaagaag atgcagatgc tgaagctgga caaggagaac gccatcgacc      300

gcgccgagca ggccgaagcc gacaagaagc aagctgagga ccgctgcaag cagctggagg      360

aggagcagca ggccctccag aagaagctga aggggacaga ggatgaggtg gaaaagtatt      420

ctgaatccgt gaaggaggcc caggagaaac tggagcaggc cgagaagaag gccactgatg      480

ctgaggcaga tgtggcctcc ctgaaccgcc gcattcagct ggttgaggag gagctggacc      540

gggcccagga gcgcctggct acagccctgc agaagctgga ggaggccgag aaggcggctg      600

atgagagcga gagaggaatg aaggtcatcg aaaaccgggc catgaaggat gaggagaaga      660

tggaactgca ggagatgcag ctgaaggagg ccaagcacat cgctgaggat tcagaccgca      720

aatatgaaga ggtggccagg aagctggtga tcctggaagg agagctggag cgctcggagg      780

agagggctga ggtggccgag agtaaatgtg gggacctaga ggaggagctg aaaattgtta      840

ccaacaactt gaaatccctg gaggcccagg cggacaagta ttccaccaaa gaagataaat      900

atgaagagga gatcaaactg ttggaggaga agctgaagga ggctgagacc cgagcagagt      960

ttgccgagag gtctgtggca aagttggaga aaaccatcga tgacctagaa gatgaagtct     1020

atgcccagaa gatgaagtac aaggccatta gcgaggaact ggacaacgca ctcaatgaca     1080

tcacctccct ctgagcccca cgccagcgtg gccacctcag ctctcttctc tcctctcctt     1140

tccattctct ctatggggag gggagcaggc aggaggagca gaaattgcca acattgcaca     1200

gccaggctgg gagcagccta gggagagccc ccatcatgcc caccacccac tctggcactg     1260

gcttcatcct ttacctatcc ccttccaccc tcctttgctg cttaataaat tctgaacttg     1320

gtctcca                                                               1327


<210>  38
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Ile Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Gln Ala 
            20                  25                  30          


Glu Asp Arg Cys Lys Gln Leu Glu Glu Glu Gln Gln Ala Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Val Glu Lys Tyr Ser Glu Ser Val 
    50                  55                  60                  


Lys Glu Ala Gln Glu Lys Leu Glu Gln Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Asn Arg Ala Met Lys Asp Glu Glu Lys Met Glu Leu Gln 
    130                 135                 140                 


Glu Met Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ser Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu 
                165                 170                 175     


Glu Arg Ser Glu Glu Arg Ala Glu Val Ala Glu Ser Lys Cys Gly Asp 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Ile Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Gln Ala Asp Lys Tyr Ser Thr Lys Glu Asp Lys Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Leu Leu Glu Glu Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu 
                245                 250                 255     


Glu Asp Glu Val Tyr Ala Gln Lys Met Lys Tyr Lys Ala Ile Ser Glu 
            260                 265                 270         


Glu Leu Asp Asn Ala Leu Asn Asp Ile Thr Ser Leu 
        275                 280                 


<210>  39
<211>  1384
<212>  DNA
<213>  Homo sapiens

<400>  39
gtaagaaacg gttgaactgg atgcaatttt tatcacagct tgtgtaagac tgcctctgtc       60

cctcctctca catgccattg gttaaccagc agacagtgtg ctcaggggcg ttgccagctc      120

attgctctta tagcctgtga gggaggaaga aagaaacatt tgccagccag gctagtgaca      180

gaaatggatt cgaaatatca gtgtgtgaag ctgaatgatg gtcacttcat gcctgtcctg      240

ggatttggca cctatgcgcc tgcagaggtt cctaaaagta aagctttaga ggccaccaaa      300

ttggcaattg aagctggctt ccgccatatt gattctgctc atttatacaa taatgaggag      360

caggttggac tggccatccg aagcaagatt gcagatggca gtgtgaagag agaagacata      420

ttctacactt caaagctttg gtgcaattcc catcgaccag agttggtccg accagccttg      480

gaaaggtcac tgaaaaatct tcaattggat tatgttgacc tctaccttat tcattttcca      540

gtgtctgtaa agccaggtga ggaagtgatc ccaaaagatg aaaatggaaa aatactattt      600

gacacagtgg atctctgtgc cacatgggag gccgtggaga agtgtaaaga tgcaggattg      660

gccaagtcca tcggggtgtc caacttcaac cgcaggcagc tggagatgat cctcaacaag      720

ccagggctca agtacaagcc tgtctgcaac caggtggaat gtcatcctta cttcaaccag      780

agaaaactgc tggatttctg caagtcaaaa gacattgttc tggttgccta tagtgctctg      840

ggatcccacc gagaagaacc atgggtggac ccgaactccc cggtgctctt ggaggaccca      900

gtcctttgtg ccttggcaaa aaagcacaag cgaaccccag ccctgattgc cctgcgctac      960

cagctacagc gtggggttgt ggtcctggcc aagagctaca atgagcagcg catcagacag     1020

aacgtgcagg tgtttgaatt ccagttgact tcagaggaga tgaaagccat agatggccta     1080

aacagaaatg tgcgatattt gacccttgat atttttgctg gcccccctaa ttatccattt     1140

tctgatgaat attaacatgg agggcattgc atgaggtctg ccagaaggcc ctgcgtgtgg     1200

atggtgacac agaggatggc tctatgctgg tgactggaca catcgcctct ggttaaatct     1260

ctcctgcttg gtgatttcag caagctacag caaagcccat tggccagaaa ggaaagacaa     1320

taattttgtt ttttcatttt gaaaaaatta aatgctctct cctaaagatt cttcacctaa     1380

aaaa                                                                  1384


<210>  40
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Ala Glu Val Pro Lys Ser 
            20                  25                  30          


Lys Ala Leu Glu Ala Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Cys Asn Ser His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val 
        115                 120                 125             


Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Thr Val Asp Leu 
    130                 135                 140                 


Cys Ala Thr Trp Glu Ala Val Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Gln Arg Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser His Arg Glu 
    210                 215                 220                 


Glu Pro Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Thr Ser Glu Glu Met Lys Ala Ile Asp Gly Leu Asn Arg Asn Val Arg 
    290                 295                 300                 


Tyr Leu Thr Leu Asp Ile Phe Ala Gly Pro Pro Asn Tyr Pro Phe Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210>  41
<211>  1224
<212>  DNA
<213>  Homo sapiens

<400>  41
gcccattgtt tttgtaatct ctgaggagaa gcagcagcaa acatttgcta gtcagacaag       60

tgacagggaa tggattccaa acaccagtgt gtaaagctaa atgatggcca cttcatgcct      120

gtattgggat ttggcaccta tgcacctcca gaggttccga gaagtaaagc tttggaggtc      180

acaaaattag caatagaagc tgggttccgc catatagatt ctgctcattt atacaataat      240

gaggagcagg ttggactggc catccgaagc aagattgcag atggcagtgt gaagagagaa      300

gacatattct acacttcaaa gctttggtcc acttttcatc gaccagagtt ggtccgacca      360

gccttggaaa actcactgaa gaaagctcaa ttggactatg ttgacctcta tcttattcat      420

tctccaatgt ctctaaagcc aggtgaggaa ctttcaccaa cagatgaaaa tggaaaagta      480

atatttgaca tagtggatct ctgtaccacc tgggaggcca tggagaagtg taaggatgca      540

ggattggcca agtccattgg ggtgtcaaac ttcaaccgca ggcagctgga gatgatcctc      600

aacaagccag gactcaagta caagcctgtc tgcaaccagg tagaatgtca tccgtatttc      660

aaccggagta aattgctaga tttctgcaag tcgaaagata ttgttctggt tgcctatagt      720

gctctgggat ctcaacgaga caaacgatgg gtggacccga actccccggt gctcttggag      780

gacccagtcc tttgtgcctt ggcaaaaaag cacaagcgaa ccccagccct gattgccctg      840

cgctaccagc tgcagcgtgg ggttgtggtc ctggccaaga gctacaatga gcagcgcatc      900

agacagaacg tgcaggtttt tgagttccag ttgactgcag aggacatgaa agccatagat      960

ggcctagaca gaaatctcca ctattttaac agtgatagtt ttgctagcca ccctaattat     1020

ccatattcag atgaatatta acatggaggg ctttgcctga tgtctaccag aagccctgtg     1080

tgtggatggt gacgcagagg acgtctctat gccggtgact ggacatatca cctctactta     1140

aatccgtcct gtttagcgac ttcagtcaac tacagctgag tccataggcc agaaagacaa     1200

taaattttta tcattttgaa ataa                                            1224


<210>  42
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Asp Ser Lys His Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Pro Glu Val Pro Arg Ser 
            20                  25                  30          


Lys Ala Leu Glu Val Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Ser Thr Phe His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Asn Ser Leu Lys Lys Ala Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Ser Pro Met Ser Leu Lys Pro Gly Glu Glu Leu 
        115                 120                 125             


Ser Pro Thr Asp Glu Asn Gly Lys Val Ile Phe Asp Ile Val Asp Leu 
    130                 135                 140                 


Cys Thr Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Arg Ser Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser Gln Arg Asp 
    210                 215                 220                 


Lys Arg Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Thr Ala Glu Asp Met Lys Ala Ile Asp Gly Leu Asp Arg Asn Leu His 
    290                 295                 300                 


Tyr Phe Asn Ser Asp Ser Phe Ala Ser His Pro Asn Tyr Pro Tyr Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210>  43
<211>  1610
<212>  DNA
<213>  Homo sapiens

<400>  43
acagtagctc acacctgtaa tcccagcact ttggaaggcc gaggtgggcg gatcacctga       60

gctcaggagt ttgagaccag cctgtctcta ctaacaatat aaaaattagc tgggagtcac      120

ggtgggcgcc tgtaatccca gctactcggg aggctgaggc aggagaattg cttgaaccca      180

ggagacagag gttgtagtga gctgagatcg caccactgca ctctagcctt ggcaacagtg      240

caagactgtc tcaaaaacag caacagagag caggacgtga gacttctacc tgctcactca      300

gaatcatttc tgcaccaacc atggccacgt ttgtggagct cagtaccaaa gccaagatgc      360

ccattgtggg cctgggcact tggaagtctc ctcttggcaa agtgaaagaa gcagtgaagg      420

tggccattga tgcaggatat cggcacattg actgtgccta tgtctatcag aatgaacatg      480

aagtggggga agccatccaa gagaagatcc aagagaaggc tgtgaagcgg gaggacctgt      540

tcatcgtcag caagttgtgg cccactttct ttgagagacc ccttgtgagg aaagcctttg      600

agaagaccct caaggacctg aagctgagct atctggacgt ctatcttatt cactggccac      660

agggattcaa gtctggggat gaccttttcc ccaaagatga taaaggtaat gccatcggtg      720

gaaaagcaac gttcttggat gcctgggagg ccatggagga gctggtggat gaggggctgg      780

tgaaagccct tggggtctcc aatttcagcc acttccagat cgagaagctc ttgaacaaac      840

ctggactgaa atataaacca gtgactaacc aggttgagtg tcacccatac ctcacacagg      900

agaaactgat ccagtactgc cactccaagg gcatcaccgt tacggcctac agccccctgg      960

gctctccgga tagaccttgg gccaagccag aagacccttc cctgctggag gatcccaaga     1020

ttaaggagat tgctgcaaag cacaaaaaaa ccgcagccca ggttctgatc cgtttccata     1080

tccagaggaa tgtgattgtc atccccaagt ctgtgacacc agcacgcatt gttgagaaca     1140

ttcaggtctt tgactttaaa ttgagtgatg aggagatggc aaccatactc agcttcaaca     1200

gaaactggag ggcctgtaac gtgttgcaat cctctcattt ggaagactat cccttcaatg     1260

cagaatattg aggttgaatc tcctggtgag attatacagg agattctctt tcttcgctga     1320

agtgtgacta cctccactca tgtcccattt tagccaagct tatttaagat cacagtgaac     1380

ttagtcctgt tatagacgag aatcgaggtg ctgttttaga catttatttc tgtatgttca     1440

actaggatca gaatatcaca gaaaagcatg gcttgaataa ggaaatgaca attttttcca     1500

cttatctgat cagaacaaat gtttattaag catcagaaac tctgccaaca ctgaggatgt     1560

aaagatcaat aaaaaaaata ataatcataa ccaacaaaaa aaaaaaaaaa                1610


<210>  44
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Thr Phe Val Glu Leu Ser Thr Lys Ala Lys Met Pro Ile Val 
1               5                   10                  15      


Gly Leu Gly Thr Trp Lys Ser Pro Leu Gly Lys Val Lys Glu Ala Val 
            20                  25                  30          


Lys Val Ala Ile Asp Ala Gly Tyr Arg His Ile Asp Cys Ala Tyr Val 
        35                  40                  45              


Tyr Gln Asn Glu His Glu Val Gly Glu Ala Ile Gln Glu Lys Ile Gln 
    50                  55                  60                  


Glu Lys Ala Val Lys Arg Glu Asp Leu Phe Ile Val Ser Lys Leu Trp 
65                  70                  75                  80  


Pro Thr Phe Phe Glu Arg Pro Leu Val Arg Lys Ala Phe Glu Lys Thr 
                85                  90                  95      


Leu Lys Asp Leu Lys Leu Ser Tyr Leu Asp Val Tyr Leu Ile His Trp 
            100                 105                 110         


Pro Gln Gly Phe Lys Ser Gly Asp Asp Leu Phe Pro Lys Asp Asp Lys 
        115                 120                 125             


Gly Asn Ala Ile Gly Gly Lys Ala Thr Phe Leu Asp Ala Trp Glu Ala 
    130                 135                 140                 


Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Leu Gly Val Ser 
145                 150                 155                 160 


Asn Phe Ser His Phe Gln Ile Glu Lys Leu Leu Asn Lys Pro Gly Leu 
                165                 170                 175     


Lys Tyr Lys Pro Val Thr Asn Gln Val Glu Cys His Pro Tyr Leu Thr 
            180                 185                 190         


Gln Glu Lys Leu Ile Gln Tyr Cys His Ser Lys Gly Ile Thr Val Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 
    210                 215                 220                 


Asp Pro Ser Leu Leu Glu Asp Pro Lys Ile Lys Glu Ile Ala Ala Lys 
225                 230                 235                 240 


His Lys Lys Thr Ala Ala Gln Val Leu Ile Arg Phe His Ile Gln Arg 
                245                 250                 255     


Asn Val Ile Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Val Glu 
            260                 265                 270         


Asn Ile Gln Val Phe Asp Phe Lys Leu Ser Asp Glu Glu Met Ala Thr 
        275                 280                 285             


Ile Leu Ser Phe Asn Arg Asn Trp Arg Ala Cys Asn Val Leu Gln Ser 
    290                 295                 300                 


Ser His Leu Glu Asp Tyr Pro Phe Asn Ala Glu Tyr 
305                 310                 315     


<210>  45
<211>  1069
<212>  DNA
<213>  Homo sapiens

<400>  45
aagtaattcc tagacccgta ggtggccgca gagccggtta cctctggttc tgcgccagcg       60

tgccccaccc gcaggacggc cgggttcttt gatttgtaca ctttctaaaa ccaaacccga      120

gaggaagggc aggctcaggg tggggatgcc ctgaaatatt cgagagcagg accgtttcta      180

ctgaagagaa gtttacaaga acgctctgtc tggggcgggc gaggcctctg cgaggcgggt      240

ccgggagcga gggcagggcg tgggccgcgc gcccggggtc gggggagtcg ggggcaggaa      300

gagggggagg agacagggct gggggagcgc cctgccgagc gcccgccagg ctcctcccgc      360

tcccgcgccg cctccctcta cccacccgcc gcacgtacta aggaaggcgc acagcccgcc      420

gcgctcgcct ctccgccccg cgtccagctc gcccagctcg cccagcgtcc gccgcgcctc      480

ggccaaggct tcaacggacc acaccaaaat gccatctcaa atggaacacg ccatggaaac      540

catgatgttt acatttcaca aattcgctgg ggataaaggc tacttaacaa aggaggacct      600

gagagtactc atggaaaagg agttccctgg atttttggaa aatcaaaaag accctctggc      660

tgtggacaaa ataatgaagg acctggacca gtgtagagat ggcaaagtgg gcttccagag      720

cttcttttcc ctaattgcgg gcctcaccat tgcatgcaat gactattttg tagtacacat      780

gaagcagaag ggaaagaagt aggcagaaat gagcagttcg ctcctccctg ataagagttg      840

tcccaaaggg tcgcttaagg aatctgcccc acagcttccc ccatagaagg atttcatgag      900

cagatcagga cacttagcaa atgtaaaaat aaaatctaac tctcatttga caagcagaga      960

aagaaaagtt aaataccaga taagcttttg atttttgtat tgtttgcatc cccttgccct     1020

caataaataa agttcttttt tagttccaaa tttgaaaaaa aaaaaaaaa                 1069


<210>  46
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Pro Ser Gln Met Glu His Ala Met Glu Thr Met Met Phe Thr Phe 
1               5                   10                  15      


His Lys Phe Ala Gly Asp Lys Gly Tyr Leu Thr Lys Glu Asp Leu Arg 
            20                  25                  30          


Val Leu Met Glu Lys Glu Phe Pro Gly Phe Leu Glu Asn Gln Lys Asp 
        35                  40                  45              


Pro Leu Ala Val Asp Lys Ile Met Lys Asp Leu Asp Gln Cys Arg Asp 
    50                  55                  60                  


Gly Lys Val Gly Phe Gln Ser Phe Phe Ser Leu Ile Ala Gly Leu Thr 
65                  70                  75                  80  


Ile Ala Cys Asn Asp Tyr Phe Val Val His Met Lys Gln Lys Gly Lys 
                85                  90                  95      


Lys 
    


<210>  47
<211>  1929
<212>  DNA
<213>  Homo sapiens

<400>  47
gcggcgtccg tccgtactgc agagccgctg ccggagggtc gttttaaagg gcccgcgcgt       60

tgccgccccc tcggcccgcc atgctgctat ccgtgccgct gctgctcggc ctcctcggcc      120

tggccgtcgc cgagcctgcc gtctacttca aggagcagtt tctggacgga gacgggtgga      180

cttcccgctg gatcgaatcc aaacacaagt cagattttgg caaattcgtt ctcagttccg      240

gcaagttcta cggtgacgag gagaaagata aaggtttgca gacaagccag gatgcacgct      300

tttatgctct gtcggccagt ttcgagcctt tcagcaacaa aggccagacg ctggtggtgc      360

agttcacggt gaaacatgag cagaacatcg actgtggggg cggctatgtg aagctgtttc      420

ctaatagttt ggaccagaca gacatgcacg gagactcaga atacaacatc atgtttggtc      480

ccgacatctg tggccctggc accaagaagg ttcatgtcat cttcaactac aagggcaaga      540

acgtgctgat caacaaggac atccgttgca aggatgatga gtttacacac ctgtacacac      600

tgattgtgcg gccagacaac acctatgagg tgaagattga caacagccag gtggagtccg      660

gctccttgga agacgattgg gacttcctgc cacccaagaa gataaaggat cctgatgctt      720

caaaaccgga agactgggat gagcgggcca agatcgatga tcccacagac tccaagcctg      780

aggactggga caagcccgag catatccctg accctgatgc taagaagccc gaggactggg      840

atgaagagat ggacggagag tgggaacccc cagtgattca gaaccctgag tacaagggtg      900

agtggaagcc ccggcagatc gacaacccag attacaaggg cacttggatc cacccagaaa      960

ttgacaaccc cgagtattct cccgatccca gtatctatgc ctatgataac tttggcgtgc     1020

tgggcctgga cctctggcag gtcaagtctg gcaccatctt tgacaacttc ctcatcacca     1080

acgatgaggc atacgctgag gagtttggca acgagacgtg gggcgtaaca aaggcagcag     1140

agaaacaaat gaaggacaaa caggacgagg agcagaggct taaggaggag gaagaagaca     1200

agaaacgcaa agaggaggag gaggcagagg acaaggagga tgatgaggac aaagatgagg     1260

atgaggagga tgaggaggac aaggaggaag atgaggagga agatgtcccc ggccaggcca     1320

aggacgagct gtagagaggc ctgcctccag ggctggactg aggcctgagc gctcctgccg     1380

cagagctggc cgcgccaaat aatgtctctg tgagactcga gaactttcat ttttttccag     1440

gctggttcgg atttggggtg gattttggtt ttgttcccct cctccactct cccccacccc     1500

ctccccgccc tttttttttt ttttttttaa actggtattt tatctttgat tctccttcag     1560

ccctcacccc tggttctcat ctttcttgat caacatcttt tcttgcctct gtccccttct     1620

ctcatctctt agctcccctc caacctgggg ggcagtggtg tggagaagcc acaggcctga     1680

gatttcatct gctctccttc ctggagccca gaggagggca gcagaagggg gtggtgtctc     1740

caacccccca gcactgagga agaacggggc tcttctcatt tcacccctcc ctttctcccc     1800

tgcccccagg actgggccac ttctgggtgg ggcagtgggt cccagattgg ctcacactga     1860

gaatgtaaga actacaaaca aaatttctat taaattaaat tttgtgtctc caaaaaaaaa     1920

aaaaaaaaa                                                             1929


<210>  48
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
    370                 375                 380                 


Lys Glu Asp Asp Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp 
385                 390                 395                 400 


Lys Glu Glu Asp Glu Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu 
                405                 410                 415     


Leu 
    


<210>  49
<211>  2463
<212>  DNA
<213>  Homo sapiens

<400>  49
gtcctgtttc tctccctgtt gtccctgcct ctttttcctt cccgccgtgc cccgcggccg       60

ggccggggca gccgggaagc gggtggggtg gtgtgttacc cagtagctcc tgggacatcg      120

ctcgggtacg ctccacgccg tcgcagccac tgctgtggtc gccggtcggc cgaggggccg      180

cgatactggt tgcccgcggt gtaagcagaa ttcgacgtgt atcgctgccg tcaagatgga      240

ggggcctttg tccgtgttcg gtgaccgcag cactggggaa acgatccgct cccaaaacgt      300

tatggctgca gcttcgattg ccaatattgt aaaaagttct cttggtccag ttggcttgga      360

taaaatgttg gtggatgata ttggtgatgt aaccattact aacgatggtg caaccatcct      420

gaagttactg gaggtagaac atcctgcagc taaagttctt tgtgagctgg ctgatctgca      480

agacaaagaa gttggagatg gaactacttc agtggttatt attgcagcag aactcctaaa      540

aaatgcagat gaattagtca aacagaaaat tcatcccaca tcagttatta gtggctatcg      600

acttgcttgc aaggaagcag tgcgttatat caatgaaaac ctaattgtta acacagatga      660

actgggaaga gattgcctga ttaatgctgc taagacatcc atgtcttcca aaatcattgg      720

aataaatggt gatttctttg ctaacatggt agtagatgct gtacttgcta ttaaatacac      780

agacataaga ggccagccac gctatccagt caactctgtt aatattttga aagcccatgg      840

gagaagtcaa atggagagta tgctcatcag tggctatgca ctcaactgtg tggtgggatc      900

ccagggcatg cccaagagaa tcgtaaatgc aaaaattgct tgccttgact tcagcctgca      960

aaaaacaaaa atgaagcttg gtgtacaggt ggtcattaca gaccctgaaa aactggacca     1020

aattagacag agagaatcag atatcaccaa ggagagaatt cagaagatcc tggcaactgg     1080

tgccaatgtt attctaacca ctggtggaat tgatgatatg tgtctgaagt attttgtgga     1140

ggctggtgct atggcagtta gaagagtttt aaaaagggac cttaaacgca ttgccaaagc     1200

ttctggagca actattctgt caaccctggc caatttggaa ggtgaagaaa cttttgaagc     1260

tgcaatgttg ggacaggcag aagaagtggt acaggagaga atttgtgatg atgagctgat     1320

cttaatcaaa aatactaagg ctcgtacgtc tgcatcgatt atcttacgtg gggcaaatga     1380

tttcatgtgt gatgagatgg agcgctcttt acatgatgca ctttgtgtag tgaagagagt     1440

tttggagtca aaatctgtgg ttcccggtgg gggtgctgta gaagcagccc tttccatata     1500

ccttgaaaac tatgcaacca gcatggggtc tcgggaacag cttgcgattg cagagtttgc     1560

aagatcactt cttgttattc ccaatacact agcagttaat gctgcccagg actccacaga     1620

tctggttgca aaattaagag cttttcataa tgaggcccag gttaacccag aacgtaaaaa     1680

tctaaaatgg attggtcttg atttgagcaa tggtaaacct cgagacaaca aacaagcagg     1740

ggtgtttgaa ccaaccatag ttaaagttaa gagtttgaaa tttgcaacag aagctgcaat     1800

caccattctt cgaattgatg atcttattaa attacatcca gaaagtaaag atgataaaca     1860

tggaagttat gaagatgctg ttcactctgg agcccttaat gattgatctg atgttccttt     1920

tatttataac aatgttaaat gcaattgtct tgtaccttga gttgagtatt acacattaaa     1980

gtaaagtaca agctgtaaac ttgggttttt gtgatgtagg aaatggtttc catctgtact     2040

ttggtcctct gatttcacat attgcaacct agtactttat tagtttaaaa agaaattgag     2100

gttgttcaaa gtttaagcaa ttcattctct ctgaacacac attgctattc ccatcccacc     2160

cccaatgcac agggctgcaa caccacgact tctgcccatt ctctccagtg tgtgtaacag     2220

ggtcacaaga attcgacagc cagatgctcc aagagggtgg cccaaggcta tagcccctcc     2280

ttcaatattg acctaacggg ggagaaaaga tttagattgt ttattcttct gtggacacag     2340

tttaaaatct taaacttgtc tttttcctct taatgtatca gcatgctacc ctttcaaact     2400

caaattttca ttttaactgc ttaggaataa atttacacct ttgtgaaaat tcaaaaaaaa     2460

aaa                                                                   2463


<210>  50
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Glu Gly Pro Leu Ser Val Phe Gly Asp Arg Ser Thr Gly Glu Thr 
1               5                   10                  15      


Ile Arg Ser Gln Asn Val Met Ala Ala Ala Ser Ile Ala Asn Ile Val 
            20                  25                  30          


Lys Ser Ser Leu Gly Pro Val Gly Leu Asp Lys Met Leu Val Asp Asp 
        35                  40                  45              


Ile Gly Asp Val Thr Ile Thr Asn Asp Gly Ala Thr Ile Leu Lys Leu 
    50                  55                  60                  


Leu Glu Val Glu His Pro Ala Ala Lys Val Leu Cys Glu Leu Ala Asp 
65                  70                  75                  80  


Leu Gln Asp Lys Glu Val Gly Asp Gly Thr Thr Ser Val Val Ile Ile 
                85                  90                  95      


Ala Ala Glu Leu Leu Lys Asn Ala Asp Glu Leu Val Lys Gln Lys Ile 
            100                 105                 110         


His Pro Thr Ser Val Ile Ser Gly Tyr Arg Leu Ala Cys Lys Glu Ala 
        115                 120                 125             


Val Arg Tyr Ile Asn Glu Asn Leu Ile Val Asn Thr Asp Glu Leu Gly 
    130                 135                 140                 


Arg Asp Cys Leu Ile Asn Ala Ala Lys Thr Ser Met Ser Ser Lys Ile 
145                 150                 155                 160 


Ile Gly Ile Asn Gly Asp Phe Phe Ala Asn Met Val Val Asp Ala Val 
                165                 170                 175     


Leu Ala Ile Lys Tyr Thr Asp Ile Arg Gly Gln Pro Arg Tyr Pro Val 
            180                 185                 190         


Asn Ser Val Asn Ile Leu Lys Ala His Gly Arg Ser Gln Met Glu Ser 
        195                 200                 205             


Met Leu Ile Ser Gly Tyr Ala Leu Asn Cys Val Val Gly Ser Gln Gly 
    210                 215                 220                 


Met Pro Lys Arg Ile Val Asn Ala Lys Ile Ala Cys Leu Asp Phe Ser 
225                 230                 235                 240 


Leu Gln Lys Thr Lys Met Lys Leu Gly Val Gln Val Val Ile Thr Asp 
                245                 250                 255     


Pro Glu Lys Leu Asp Gln Ile Arg Gln Arg Glu Ser Asp Ile Thr Lys 
            260                 265                 270         


Glu Arg Ile Gln Lys Ile Leu Ala Thr Gly Ala Asn Val Ile Leu Thr 
        275                 280                 285             


Thr Gly Gly Ile Asp Asp Met Cys Leu Lys Tyr Phe Val Glu Ala Gly 
    290                 295                 300                 


Ala Met Ala Val Arg Arg Val Leu Lys Arg Asp Leu Lys Arg Ile Ala 
305                 310                 315                 320 


Lys Ala Ser Gly Ala Thr Ile Leu Ser Thr Leu Ala Asn Leu Glu Gly 
                325                 330                 335     


Glu Glu Thr Phe Glu Ala Ala Met Leu Gly Gln Ala Glu Glu Val Val 
            340                 345                 350         


Gln Glu Arg Ile Cys Asp Asp Glu Leu Ile Leu Ile Lys Asn Thr Lys 
        355                 360                 365             


Ala Arg Thr Ser Ala Ser Ile Ile Leu Arg Gly Ala Asn Asp Phe Met 
    370                 375                 380                 


Cys Asp Glu Met Glu Arg Ser Leu His Asp Ala Leu Cys Val Val Lys 
385                 390                 395                 400 


Arg Val Leu Glu Ser Lys Ser Val Val Pro Gly Gly Gly Ala Val Glu 
                405                 410                 415     


Ala Ala Leu Ser Ile Tyr Leu Glu Asn Tyr Ala Thr Ser Met Gly Ser 
            420                 425                 430         


Arg Glu Gln Leu Ala Ile Ala Glu Phe Ala Arg Ser Leu Leu Val Ile 
        435                 440                 445             


Pro Asn Thr Leu Ala Val Asn Ala Ala Gln Asp Ser Thr Asp Leu Val 
    450                 455                 460                 


Ala Lys Leu Arg Ala Phe His Asn Glu Ala Gln Val Asn Pro Glu Arg 
465                 470                 475                 480 


Lys Asn Leu Lys Trp Ile Gly Leu Asp Leu Ser Asn Gly Lys Pro Arg 
                485                 490                 495     


Asp Asn Lys Gln Ala Gly Val Phe Glu Pro Thr Ile Val Lys Val Lys 
            500                 505                 510         


Ser Leu Lys Phe Ala Thr Glu Ala Ala Ile Thr Ile Leu Arg Ile Asp 
        515                 520                 525             


Asp Leu Ile Lys Leu His Pro Glu Ser Lys Asp Asp Lys His Gly Ser 
    530                 535                 540                 


Tyr Glu Asp Ala Val His Ser Gly Ala Leu Asn Asp 
545                 550                 555     


<210>  51
<211>  1867
<212>  DNA
<213>  Homo sapiens

<400>  51
cacatagctc agttcccata aaagggctgg tttgccgcgt cggggagtgg agtgggacag       60

gtatataaag gaagtacagg gcctggggaa gaggccctgt ctaggtagct ggcaccagga      120

gccgtgggca agggaagagg ccacaccctg ccctgctctg ctgcagccag aatgggtgtg      180

aaggcgtctc aaacaggctt tgtggtcctg gtgctgctcc agtgctgctc tgcatacaaa      240

ctggtctgct actacaccag ctggtcccag taccgggaag gcgatgggag ctgcttccca      300

gatgcccttg accgcttcct ctgtacccac atcatctaca gctttgccaa tataagcaac      360

gatcacatcg acacctggga gtggaatgat gtgacgctct acggcatgct caacacactc      420

aagaacagga accccaacct gaagactctc ttgtctgtcg gaggatggaa ctttgggtct      480

caaagatttt ccaagatagc ctccaacacc cagagtcgcc ggactttcat caagtcagta      540

ccgccatttc tgcgcaccca tggctttgat gggctggacc ttgcctggct ctaccctgga      600

cggagagaca aacagcattt taccacccta atcaaggaaa tgaaggccga atttataaag      660

gaagcccagc cagggaaaaa gcagctcctg ctcagcgcag cactgtctgc ggggaaggtc      720

accattgaca gcagctatga cattgccaag atatcccaac acctggattt cattagcatc      780

atgacctacg attttcatgg agcctggcgt gggaccacag gccatcacag tcccctgttc      840

cgaggtcagg aggatgcaag tcctgacaga ttcagcaaca ctgactatgc tgtggggtac      900

atgttgaggc tgggggctcc tgccagtaag ctggtgatgg gcatccccac cttcgggagg      960

agcttcactc tggcttcttc tgagactggt gttggagccc caatctcagg accgggaatt     1020

ccaggccggt tcaccaagga ggcagggacc cttgcctact atgagatctg tgacttcctc     1080

cgcggagcca cagtccatag aatcctcggc cagcaggtcc cctatgccac caagggcaac     1140

cagtgggtag gatacgacga ccaggaaagc gtcaaaagca aggtgcagta cctgaaggac     1200

aggcagctgg cgggcgccat ggtatgggcc ctggacctgg atgacttcca gggctccttc     1260

tgcggccagg atctgcgctt ccctctcacc aatgccatca aggatgcact cgctgcaacg     1320

tagccctctg ttctgcacac agcacggggg ccaaggatgc cccgtccccc tctggctcca     1380

gctggccggg agcctgatca cctgccctgc tgagtcccag gctgagcctc agtctccctc     1440

ccttggggcc tatgcagagg tccacaacac acagatttga gctcagccct ggtgggcaga     1500

gaggtaggga tggggctgtg gggatagtga ggcatcgcaa tgtaagactc gggattagta     1560

cacacttgtt gattaatgga aatgtttaca gatccccaag cctggcaagg gaatttcttc     1620

aactccctgc cccccagccc tccttatcaa aggacaccat tttggcaagc tctatcacca     1680

aggagccaaa catcctacaa gacacagtga ccatactaat tataccccct gcaaagccca     1740

gcttgaaacc ttcacttagg aacgtaatcg tgtcccctat cctacttccc cttcctaatt     1800

ccacagctgc tcaataaagt acaagagctt aacagtgaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaa                                                               1867


<210>  52
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 
            100                 105                 110         


Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 
        115                 120                 125             


Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 
    130                 135                 140                 


Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu 
145                 150                 155                 160 


Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 
                165                 170                 175     


Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala 
            180                 185                 190         


Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe 
        195                 200                 205             


His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg 
    210                 215                 220                 


Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 
                245                 250                 255     


Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr 
            260                 265                 270         


Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr 
        275                 280                 285             


Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 
    290                 295                 300                 


Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 
305                 310                 315                 320 


Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 
                325                 330                 335     


Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 
            340                 345                 350         


Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 
        355                 360                 365             


Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 
    370                 375                 380             


<210>  53
<211>  2358
<212>  DNA
<213>  Homo sapiens

<400>  53
aaactcacac aacaactctt ccccgctgag aggagacagc cagtgcgact ccaccctcca       60

gctcgacggc agccgccccg gccgacagcc ccgagacgac agcccggcgc gtcccggtcc      120

ccacctccga ccaccgccag cgctccaggc cccgccgctc cccgctcgcc gccaccgcgc      180

cctccgctcc gcccgcagtg ccaaccatga ccgccgccag tatgggcccc gtccgcgtcg      240

ccttcgtggt cctcctcgcc ctctgcagcc ggccggccgt cggccagaac tgcagcgggc      300

cgtgccggtg cccggacgag ccggcgccgc gctgcccggc gggcgtgagc ctcgtgctgg      360

acggctgcgg ctgctgccgc gtctgcgcca agcagctggg cgagctgtgc accgagcgcg      420

acccctgcga cccgcacaag ggcctcttct gtgacttcgg ctccccggcc aaccgcaaga      480

tcggcgtgtg caccgccaaa gatggtgctc cctgcatctt cggtggtacg gtgtaccgca      540

gcggagagtc cttccagagc agctgcaagt accagtgcac gtgcctggac ggggcggtgg      600

gctgcatgcc cctgtgcagc atggacgttc gtctgcccag ccctgactgc cccttcccga      660

ggagggtcaa gctgcccggg aaatgctgcg aggagtgggt gtgtgacgag cccaaggacc      720

aaaccgtggt tgggcctgcc ctcgcggctt accgactgga agacacgttt ggcccagacc      780

caactatgat tagagccaac tgcctggtcc agaccacaga gtggagcgcc tgttccaaga      840

cctgtgggat gggcatctcc acccgggtta ccaatgacaa cgcctcctgc aggctagaga      900

agcagagccg cctgtgcatg gtcaggcctt gcgaagctga cctggaagag aacattaaga      960

agggcaaaaa gtgcatccgt actcccaaaa tctccaagcc tatcaagttt gagctttctg     1020

gctgcaccag catgaagaca taccgagcta aattctgtgg agtatgtacc gacggccgat     1080

gctgcacccc ccacagaacc accaccctgc cggtggagtt caagtgccct gacggcgagg     1140

tcatgaagaa gaacatgatg ttcatcaaga cctgtgcctg ccattacaac tgtcccggag     1200

acaatgacat ctttgaatcg ctgtactaca ggaagatgta cggagacatg gcatgaagcc     1260

agagagtgag agacattaac tcattagact ggaacttgaa ctgattcaca tctcattttt     1320

ccgtaaaaat gatttcagta gcacaagtta tttaaatctg tttttctaac tgggggaaaa     1380

gattcccacc caattcaaaa cattgtgcca tgtcaaacaa atagtctatc aaccccagac     1440

actggtttga agaatgttaa gacttgacag tggaactaca ttagtacaca gcaccagaat     1500

gtatattaag gtgtggcttt aggagcagtg ggagggtacc agcagaaagg ttagtatcat     1560

cagatagcat cttatacgag taatatgcct gctatttgaa gtgtaattga gaaggaaaat     1620

tttagcgtgc tcactgacct gcctgtagcc ccagtgacag ctaggatgtg cattctccag     1680

ccatcaagag actgagtcaa gttgttcctt aagtcagaac agcagactca gctctgacat     1740

tctgattcga atgacactgt tcaggaatcg gaatcctgtc gattagactg gacagcttgt     1800

ggcaagtgaa tttgcctgta acaagccaga ttttttaaaa tttatattgt aaatattgtg     1860

tgtgtgtgtg tgtgtgtata tatatatata tgtacagtta tctaagttaa tttaaagttg     1920

tttgtgcctt tttatttttg tttttaatgc tttgatattt caatgttagc ctcaatttct     1980

gaacaccata ggtagaatgt aaagcttgtc tgatcgttca aagcatgaaa tggatactta     2040

tatggaaatt ctgctcagat agaatgacag tccgtcaaaa cagattgttt gcaaagggga     2100

ggcatcagtg tccttggcag gctgatttct aggtaggaaa tgtggtagcc tcacttttaa     2160

tgaacaaatg gcctttatta aaaactgagt gactctatat agctgatcag ttttttcacc     2220

tggaagcatt tgtttctact ttgatatgac tgtttttcgg acagtttatt tgttgagagt     2280

gtgaccaaaa gttacatgtt tgcacctttc tagttgaaaa taaagtgtat attttttcta     2340

taaaaaaaaa aaaaaaaa                                                   2358


<210>  54
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Thr Ala Ala Ser Met Gly Pro Val Arg Val Ala Phe Val Val Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Val Gly Gln Asn Cys Ser Gly Pro 
            20                  25                  30          


Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu 
    50                  55                  60                  


Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr 
                85                  90                  95      


Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly Gly Thr Val Tyr Arg Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp 
        115                 120                 125             


Gly Ala Val Gly Cys Met Pro Leu Cys Ser Met Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Gln Thr Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro 
            180                 185                 190         


Thr Met Ile Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp 
    210                 215                 220                 


Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr 
        275                 280                 285             


Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Asn Met Met Phe Ile 
305                 310                 315                 320 


Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 


<210>  55
<211>  10943
<212>  DNA
<213>  Homo sapiens

<400>  55
ttttttttgt agagactggg gtctcactat gttgcccacg ctggtctcaa actcctgggc       60

tcaagcgatc ctcccgcttc agcctcccaa ggtgctggga ttacaggtgg agccaccgcg      120

cccggcatcg ataatctgaa tctctaacga gctcccgggc gacgttgatg cagctggtac      180

cgggaccact cttcgaaaat catcggttta gaggttttaa ttctgaatcc attgcgaaaa      240

ctgttgggcg gacagagcac tactaactcc taacttttct cagaaagctg ggctctgctt      300

tcgccagcaa cccggtccga agtcgcgggc atattctgtc tgaaatcgtg tgcaccgaaa      360

tccccgcctt gcggtggagg ctggcgctag gcggcctcag cctcggcctg ctgcgctcag      420

gaacccgcgc cccggctcct cggcgatcca ttgctctttc ctctggcgcc ggccgcaggc      480

ctcggtcacg cccccagcgg cccgttggtt tccgggtccc gcggggtgcc cccgcccaca      540

cgctatgcct taaattgggc caggctgagg cgctgctgct ggagcggccg atccgagacg      600

tggctccctg ggcggcagaa ccatgttgga cttcgcgatc ttcgccgtta ccttcttgct      660

ggcgttggtg ggagccgtgc tctacctcta tccggcttcc agacaagctg caggaattcc      720

agggattact ccaactgaag aaaaagatgg taatcttcca gatattgtga atagtggaag      780

tttgcatgag ttcctggtta atttgcatga gagatatggg cctgtggtct ccttctggtt      840

tggcaggcgc ctcgtggtta gtttgggcac tgttgatgta ctgaagcagc atatcaatcc      900

caataagaca tcggaccctt ttgaaaccat gctgaagtca ttattaaggt atcaatctgg      960

tggtggcagt gtgagtgaaa accacatgag gaaaaaattg tatgaaaatg gtgtgactga     1020

ttctctgaag agtaactttg ccctcctcct aaagctttca gaagaattat tagataaatg     1080

gctctcctac ccagagaccc agcacgtgcc cctcagccag catatgcttg gttttgctat     1140

gaagtctgtt acacagatgg taatgggtag tacatttgaa gatgatcagg aagtcattcg     1200

cttccagaag aatcatggca cagtttggtc tgagattgga aaaggctttc tagatgggtc     1260

acttgataaa aacatgactc ggaaaaaaca atatgaagat gccctcatgc aactggagtc     1320

tgttttaagg aacatcataa aagaacgaaa aggaaggaac ttcagtcaac atattttcat     1380

tgactcctta gtacaaggga accttaatga ccaacagatc ctagaagaca gtatgatatt     1440

ttctctggcc agttgcataa taactgcaaa attgtgtacc tgggcaatct gttttttaac     1500

cacctctgaa gaagttcaaa aaaaattata tgaagagata aaccaagttt ttggaaatgg     1560

tcctgttact ccagagaaaa ttgagcagct cagatattgt cagcatgtgc tttgtgaaac     1620

tgttcgaact gccaaactga ctccagtttc tgcccagctt caagatattg aaggaaaaat     1680

tgaccgattt attattccta gagagaccct cgtcctttat gcccttggtg tggtacttca     1740

ggatcctaat acttggccat ctccacacaa gtttgatcca gatcggtttg atgatgaatt     1800

agtaatgaaa actttttcct cacttggatt ctcaggcaca caggagtgtc cagagttgag     1860

gtttgcatat atggtgacca cagtacttct tagtgtattg gtgaagagac tgcacctact     1920

ttctgtggag ggacaggtta ttgaaacaaa gtatgaactg gtaacatcat caagggaaga     1980

agcttggatc actgtctcaa agagatatta aaattttata catttaaaat cattgttaaa     2040

ttgattgagg aaaacaacca tttaaaaaaa atctatgttg aatcctttta taaaccagta     2100

tcactttgta atataaacac ctatttgtac ttaattttgt aaatttggat ttttatatat     2160

catattttct taattcattg tacacatttg acttactgca cagtatattg atcattttaa     2220

tgggaaactt tagctttcta ctttttattt ttgttttttc actttctatg ccattatttt     2280

tgtattcttt ttcttagtgt gagctctaaa atcaatgttc ttgaaaaaga aattattttg     2340

cagaagttgg ggaatcatgt ttgttgaata tgtataaaat agaaacatag gctgggcgcg     2400

gtggctcaca cctgtaatcc ctacactttg ggaggctgag gcaggtggat cacctgaggt     2460

ccagagtttg agaccagtct ggccaacatg atgaaacccc atctctacta aaaatacaaa     2520

acattggccg ggagtggtgg ctcatgcctg taatcccagc actttgggat gctgaggcgg     2580

gtggatcacc tgaggtcagg agtttgcgac cagcctggcc aacatgatga aaccctgtct     2640

ctactaaaaa tacaaaaaaa ttggctgggt gtggtggccc acacctgtaa tcccagcact     2700

ttgggaggtc gaggcgggtg gatcacctga ggtccgaagt tcgaggccag cctggccaac     2760

aggatgaaac cctgtctcta ttaaaaatac agaaaattgg ccgggtgcgg tggctcaccc     2820

ctgtaatccc agtactttgg gaggctgagg cgggtggagc acctgaggtc aggaattcga     2880

gatcagcctg gccaacatgg tgaaacccca tctctactga aaaacacaca caaaaaaatt     2940

agctgggcat ggtggcacat gcctgtaatc ccagctactc aggaggctga ggcaggagaa     3000

tcatttgaac ctgggaggcg gagcttgcag tgagccgaga ttgcacccct gcactccagc     3060

ctgggccaca gagcaagact ctgtctcaag aaaaacaaaa aaaaagataa atggacaaaa     3120

gacatgaaca aacagctttt ataggatagt atggctaaca aacttttaga aaagtgttta     3180

gtctcactag taagtaacaa aatattgggg cagggcacag tggctcatgc gtataatcct     3240

agaactttgg aaggccaaag ctggtggatt gcttgagccc aggagtttga gaccagccca     3300

ggcaacattg ggagaccctg cctctacaaa tatacaaaaa aattactggg catggtgaca     3360

cacacctgta gtcccagctg ttctgaaggc tgaggtggga ggatcacttg agaccaggag     3420

aggtcaaggc tgcagtgatc tgtgatcaca ccactgcact ccagcctggg caacagagca     3480

aaaccctgcc tttaaaaaaa caaaaaacaa aaaaggccgg gctcggtggc tcatgcctat     3540

aatactttgg gaggccgagg caggtggatc aattgaggtc aggtgttcga gaccagccag     3600

gccaacttgg tgaaaccccg tctctactaa aaatacaaaa aaaaaaaaaa aaaattagcc     3660

agatgtggtg gtgcacattt gtaatcccag ctactcagga ggctgaggca ggataatcgc     3720

ttgaacctgg gaggcagagg ttgcagtgag ccaagatcgc accactgcac tccagcctgg     3780

gtgtcgagtg aaactcattc tcaaaaaaaa aaaaaaaagg aggtggggag agctatttca     3840

agaatatttt aagtaggctg ggcacggtag ctcatgcctg ttatcctaac actttgggaa     3900

gccgacatgg gcagatcacg aggtcaagag atttgagacc atcctggcca acatggtgaa     3960

accccatctc tactaaaaat acaaaaaatt atctggacat gctggcgtgc gcctgtagtc     4020

tcagctactt gggaggctga ggcaggagaa tcgcttgaac ctgggaggcg gaggttgcag     4080

tgagctgatg ttgtgctagt gcactccagc ctgggcgaca gggctgagac cttgtctcaa     4140

aaaaaaaagg agtatcttaa gtgtctttca aaattacact ttagcactta taaattttat     4200

atataatact ttactgatag cattgtatat tagtccaact tttttggcta cactatttgt     4260

gaaggattcc tttttttctt taagacagcc actgtaggaa atatgccaag tacagatagt     4320

gaggaaagaa aggaagaaaa atgataattg tctgcaagtg ggcttatttt taacactgct     4380

gaatttcatt tgtaatttta ctttcaagaa tatactctgg tagactgagg cgggaggatc     4440

acttgagccc aggagttgga ggcttcagtg agctgtgatc acaccactgc cctcagccaa     4500

acctgagtga taaagtgaga ccctatctct taaaaaaaaa aatccctttg ttgttgagtt     4560

attttatgtc atttattggt aaatacctaa cattttagac ctagtcatta ccagttaaca     4620

tagaatttaa ttggatgcag tctgtatttt tgaaaaaaaa aatttttttt ggaataactt     4680

aaattctaaa actttggccg ggcgtgatgg ctcatgcctg taatcccagc actttgggag     4740

gccgaggcag gcagatcacc tgaggtcagg cgttcaagac cagcctgacc aacatggaga     4800

aaccccgtct ctactaaaaa tacaaaatta gccaggcttg gtggtgcatg cctgtaatac     4860

cagctactcg ggaggctgaa gcaggagaac tgcttgaacc tgggaggcag aggttgcggt     4920

gagccaagat cgcgccattg cactccagcc tgggcaacaa gagtgaaact ccgtctcaaa     4980

aaaaaaagaa aaattctaaa actttaagtg aaatttatta tcccttccca cttattttct     5040

gtggttttgt gtgtatagag catcttcctt tgttacccaa gtacctcgaa tgggttggaa     5100

actggcggta gaaggttaga gtagccaatt gatatgtaaa ccaagtgtca gatcagatga     5160

gatgaaagag gtggagttta aagcaagtga gatatgataa acaatgatga aagcaaaaat     5220

agggcagttg aaccagagtc agccagttgg cataactgcc aataaatgag gcagtgtaga     5280

ataactaata atgattggaa tcaaggaaaa gagagcatag aggaatcagc taaattagta     5340

tgttttatcc atagttacat gactaacaaa tgattaaaaa gaagttattc tctagataat     5400

tttttaaata aaagtactgt taatatataa actaagttat tcattcactg tttttcttca     5460

cagtaagaat gacaaaaatc tgtgttcttt gtacttatca agtgactcaa attttggcca     5520

cttcactgtc actgatggct tatagaatga ttctagcagg actcaagtta ttgaactatc     5580

aaatgggttt ttaattgata ttgaagtaag taagttttgt agcttttgga gtttttaaaa     5640

actacttcag tgattttgat ttatattctt tttgatagtt cagaagtgta ttgttaaaaa     5700

acataagcat ggccgggcac agtggctcac acctgtaatc ccagctcttt gggaggccaa     5760

ggcgggtaaa tcacctgagg ttgggagttt gagaccagcc tgaccaacat ggagaaaccc     5820

tgtctctacc aaaaatacaa aattagccgg gcatgatgga gcatccctgt aatcctagct     5880

acttgagacg ctgaggcagg aaaattgctt gaacccgtga ggcagaggtt gcgatgagcc     5940

gagatcgtgc cattgcactc cagcctgggc aataagagca aaactccgtc tcagaaaaaa     6000

aaaaaaaaaa aaaaaacggc caggcgaggt ggctcacacc tgtaatccca gcactttggg     6060

aggctgaggc gggcagatca cctgaagtca ggagttcaag accagcctga ccaacatgga     6120

gaaacttcat ctctactaaa aatacaaaat tagccgggcg tggtggcaca tgcctttaat     6180

cccagctact ggggaggctg aaacaggaga atcgcttgaa cccagtaggg gaaggttgtg     6240

gtgagccaag attgcaccat tgcactccag cctgggcaag aagagtgaaa ctctatccaa     6300

aaaaaaaaaa aaaccatacg tacataactt tttttctttt tcttttcttt ctttcttttc     6360

ttttcttttt tttttttgag gcacagtctt gctttgttga ccaagctgga gtgcattggc     6420

atgatcacag cttactgtag cctccacctc ctgggctcca gcgatctcac ctcagcctct     6480

agaatagctg ggactacata tgcatgccac catgcccagc tgtttttttg tttgcttgtt     6540

tttggttttg tttttttgag acagggtctc cctgcgtcgc ccagtcttgt ctcaaactcc     6600

taggctcaag cgatcctccc acctgggcct cccaaagtgt tgagattgca ggtgtgagcc     6660

acggcacctg gtccataaaa cattttttta tgaactaaag agctctctca aacttgtgct     6720

aacaaaattt aaggcaatat taattctgtg catgtgtttg ggaaaattaa aaaaacttac     6780

atagtgctta tttggcccac aaaagtacag ttccattttt tatataaata gattctacct     6840

aacttataac ccctatgtca aaatttgttt atcttaaaat agtttgtata aaaagtcttt     6900

actgctttat tatgaaataa taatgtttat tgtagaaaaa tctaggaaaa cacaaaaatg     6960

tcaaactcag ttaacagtca tagtttcact atttgaagtt aaccactgtt aagattcttt     7020

tttttttttt tttttttttg ttttgagact gagtcccgct gtctattgcc caggctggag     7080

tgccatggca ccatctcggc tcactgcaac ctctgcttcc caggttcaag tgatcctccc     7140

gcctcagcct cccaagtagc tgggattgca aacatgtgcc accacacctg gctaattttt     7200

gtgtttttag tacagatggg gtttcaccat gttggccagg ctggcctcga actcctcaac     7260

ctcaagtagt ctgcccacct tgacctccca aagtgctggg attacaggca tggggcacca     7320

tgcccagccc cactgttaag attctaatgt aggccgggca cagtgactca tgcctataac     7380

tcaagcactt tgggagttca aggcggccag attgcttgag cttttagaag tttgagacca     7440

gcctgggcaa cgtggcaaaa gcttgtttct ataaaaaaat ataaaaactt agccagcctt     7500

ggtggcacca cctgcagtcc caactattca ggaggctgag gcgagaggat ggcttgagct     7560

caggaagtca aggctacagt gagctgtggt agtgccactg cactccctca tggttgacag     7620

agcaagaccc tgtctcaaaa gattctaata tagatactct ttttatgcat atgtaattta     7680

tatatattat acaaaatatt atttgcattt aacatattct gaaccaatag tcttttctac     7740

aagcagaaca ttagtattct tgtcactctg aatgtaggca cagatttttg tcattcttta     7800

tcttttttgt gtgtgtgtga cagagtctca ctgtcaccag gctggaatgc agtggcgtga     7860

tctcggctca ctgcaacctc tgcctcccag gttcaagcga ttctcttgcc tcagcctttt     7920

gagtaactgg ggttacaggc gcgtgccatc acacccagct catttttgta tttttagtag     7980

agatggggtt ttaccgtgtt ggtcaggctg gtcctgaact cttgaccttg tgatctgccc     8040

aactcagcct cccagagtgc tgggattaca agcatgagcc accgcgctcg gtccctttct     8100

ttttatttat ttatttattt tgagatggag tctcgctgtg tcacccaggc tggagtgtgg     8160

tggcacgatc ttggctcact gcaacccctg cctcccaggt tcaagcaatt ctcctgcctc     8220

agcctcctga gtagctgaga ctacgggtat gtgccactac actcagctaa tttttgtatt     8280

tttttttagt agagacaggg tttcaccatg ttggccaggc tggtcttgaa ctcctaacct     8340

caggtgattc acaccccttg gcctcctgaa gtgctgggat tacaggcatg agccactgtg     8400

cccggccatt tttttgtgtt tttagtggag acaggttttc accatgttgg ccagtagtgt     8460

atttagttat ttaaggaggg ctcaatcaac aggtttaaat ggtgtgctat tcataattat     8520

tgcaaaaata ggccgggcct gtaattccag cactttggga ggccaaggca ggtgaatcac     8580

ttgaggccag gagtttgaga tcagcctggc caacgtggtg aaactccatc tctactaaaa     8640

ataccaaaag tagcgggcgt ggtgacaggt gcctctaatc ccagctactc gggaggctga     8700

ggcaggagaa tcgcttgaac ccaagagtcg gaggttgcag tgagccgaga tcgcgccatt     8760

gcactccagt gtgggtgacg agcgaaaatc cgtctcaacc aagaaaaaag aaaaaaagaa     8820

aaagaaaact taactggcct ttggggcaca tgcctgtaat cccagcttct tgggaggctg     8880

aggcatgaga aaaaaaataa acctgggagg tggaggttgc agtgagttga gattgtgcca     8940

ctgcactcca gcttaggcaa taaaacaaga ctgtctcaaa aaaaaaaaaa aaaaaaactt     9000

attgagagaa taatatacca ctaatattta aagaaatttt tggctggtgc cgtggctcac     9060

acctgtaatc ccagcacttt gggagtccaa agtgggcgta taacttgagg tcaggagttc     9120

aagaacagcc tggccaacat ggggaaaccg catctctact aaaaatacaa aaattagtgg     9180

gtgtggaggc gggcgaatgt aatcccagct agttgagagg ctgaggcagg agaatgtctg     9240

ggaggtggag gttgcagtgt gccgagatcg caccactgta ctccagccta ggtgacagag     9300

tgagactcca taggtctcag ccagactctg gaggtctcag cccaggcttg agtgcagtgg     9360

catgatctgg gctcactaca acctccatct ccccagttca agcgattctc ctgcctcagc     9420

ctcccgagta gctgcgacta caggcgagtg cctccatgcc cagctaattt tttgtatttt     9480

tagtagagac ggggtttcac catgttagcc aggatggtct tgatctcctg accttgtgat     9540

ctgtccaccg cggcttccca aagtgctggg attacaggtg tgagccacag cgcccggcca     9600

aaaaaaggaa tttttaagag gaaaaagaat gctaccaacc taaacacatt tctgtgactg     9660

tttatatttt tccctgttcc acatacatac atttttacat agtacgttca ttgcagcatg     9720

agttactttt cacttaataa attttaaaca ttttccagct gggtgtggtg gctcatgcct     9780

gtaatcccaa cacttggaga ggccaagtca ggcttattgg gtgagtccag gtgtttgaga     9840

ctagcctagg caacatggcg aaactgcatc tctacaaaaa atacaaaaat tagccaggtg     9900

tgctggcgca cacctgtagt cccaactact caggaggctg aggtgggagg attgcttgag     9960

cccaggaggt agaggttgca gtgagccatg atcatgccac tgcactccag cctaggtgac    10020

aaagcacaac cctcaaataa ataaataaat acatgttaaa catatacctt tattacttca    10080

tttttgtaag agcttcaggg aataggcttt tttaaaggga atagacttat agatcaattt    10140

taatatttga cttatagaat tttatgacac taaatggata attgtaaagt ttgagttggg    10200

acccattttt taagacattc aggctataaa caaggtaata aatcacactc ttccagttct    10260

actcccaatt taattggttt acagttcggt ggctgtcttt tttttttttt tttttttttt    10320

ttgagaccga gtctccctct gtcaccaggc tggagtgcag tggtgcaatc tcagctcact    10380

gcaacctccc cctctcaggt tcaagtaatt ctcctgcctc agcctgccga gtagctggga    10440

ctacagtcgc acgccaacca cccccagcta atttttttat ttttagtaga gacaggattt    10500

caccatgttt gccaggatgg tctcgatctc ttgtgctcat aatctaccta cctcggcctc    10560

ccaaagtgct cggattacag acgtgagcca ctgcgcccgg cccgttggct tgctttctag    10620

atactgggaa tagatcttgt tatagtatgt gataaataga tcttgttata gtatgtgata    10680

aaatgccatg atcaaataaa ttacttatat cctgtttggt gatttttaga aaaacatatt    10740

tatctacatc taaaatactt attttaattt taaacacttg atggtatgaa atgaaatttt    10800

gttactttac cattgtaact atgtcataaa gtcataaagt acctgtcccc aaaaaggcaa    10860

ccagtaaata tttttgagta aatgaatgaa atctttattg ccggtgttct gtgcacatag    10920

aataaaggaa attattaatg tta                                            10943


<210>  56
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Leu Asp Phe Ala Ile Phe Ala Val Thr Phe Leu Leu Ala Leu Val 
1               5                   10                  15      


Gly Ala Val Leu Tyr Leu Tyr Pro Ala Ser Arg Gln Ala Ala Gly Ile 
            20                  25                  30          


Pro Gly Ile Thr Pro Thr Glu Glu Lys Asp Gly Asn Leu Pro Asp Ile 
        35                  40                  45              


Val Asn Ser Gly Ser Leu His Glu Phe Leu Val Asn Leu His Glu Arg 
    50                  55                  60                  


Tyr Gly Pro Val Val Ser Phe Trp Phe Gly Arg Arg Leu Val Val Ser 
65                  70                  75                  80  


Leu Gly Thr Val Asp Val Leu Lys Gln His Ile Asn Pro Asn Lys Thr 
                85                  90                  95      


Ser Asp Pro Phe Glu Thr Met Leu Lys Ser Leu Leu Arg Tyr Gln Ser 
            100                 105                 110         


Gly Gly Gly Ser Val Ser Glu Asn His Met Arg Lys Lys Leu Tyr Glu 
        115                 120                 125             


Asn Gly Val Thr Asp Ser Leu Lys Ser Asn Phe Ala Leu Leu Leu Lys 
    130                 135                 140                 


Leu Ser Glu Glu Leu Leu Asp Lys Trp Leu Ser Tyr Pro Glu Thr Gln 
145                 150                 155                 160 


His Val Pro Leu Ser Gln His Met Leu Gly Phe Ala Met Lys Ser Val 
                165                 170                 175     


Thr Gln Met Val Met Gly Ser Thr Phe Glu Asp Asp Gln Glu Val Ile 
            180                 185                 190         


Arg Phe Gln Lys Asn His Gly Thr Val Trp Ser Glu Ile Gly Lys Gly 
        195                 200                 205             


Phe Leu Asp Gly Ser Leu Asp Lys Asn Met Thr Arg Lys Lys Gln Tyr 
    210                 215                 220                 


Glu Asp Ala Leu Met Gln Leu Glu Ser Val Leu Arg Asn Ile Ile Lys 
225                 230                 235                 240 


Glu Arg Lys Gly Arg Asn Phe Ser Gln His Ile Phe Ile Asp Ser Leu 
                245                 250                 255     


Val Gln Gly Asn Leu Asn Asp Gln Gln Ile Leu Glu Asp Ser Met Ile 
            260                 265                 270         


Phe Ser Leu Ala Ser Cys Ile Ile Thr Ala Lys Leu Cys Thr Trp Ala 
        275                 280                 285             


Ile Cys Phe Leu Thr Thr Ser Glu Glu Val Gln Lys Lys Leu Tyr Glu 
    290                 295                 300                 


Glu Ile Asn Gln Val Phe Gly Asn Gly Pro Val Thr Pro Glu Lys Ile 
305                 310                 315                 320 


Glu Gln Leu Arg Tyr Cys Gln His Val Leu Cys Glu Thr Val Arg Thr 
                325                 330                 335     


Ala Lys Leu Thr Pro Val Ser Ala Gln Leu Gln Asp Ile Glu Gly Lys 
            340                 345                 350         


Ile Asp Arg Phe Ile Ile Pro Arg Glu Thr Leu Val Leu Tyr Ala Leu 
        355                 360                 365             


Gly Val Val Leu Gln Asp Pro Asn Thr Trp Pro Ser Pro His Lys Phe 
    370                 375                 380                 


Asp Pro Asp Arg Phe Asp Asp Glu Leu Val Met Lys Thr Phe Ser Ser 
385                 390                 395                 400 


Leu Gly Phe Ser Gly Thr Gln Glu Cys Pro Glu Leu Arg Phe Ala Tyr 
                405                 410                 415     


Met Val Thr Thr Val Leu Leu Ser Val Leu Val Lys Arg Leu His Leu 
            420                 425                 430         


Leu Ser Val Glu Gly Gln Val Ile Glu Thr Lys Tyr Glu Leu Val Thr 
        435                 440                 445             


Ser Ser Arg Glu Glu Ala Trp Ile Thr Val Ser Lys Arg Tyr 
    450                 455                 460         


<210>  57
<211>  3287
<212>  DNA
<213>  Homo sapiens

<400>  57
gacaggagga aacgcagcgc cagcagcatc tcatctaccc tccttgacac ctccccgtgg       60

ctccagccag accctagagg tcagccttgc ggaccaacag gaggactccc agctttccct      120

tttcaagagg tccccagaca ccggccaccc tcttccagcc cctgcggcca gtgcaaggag      180

gcaccaatgc tctgaggctg tcgcgtggtg cagcgtcgag catcctcgcc gaggtccttt      240

ctgctgcctg tcccgcctca ccccgctcca tcacaccagc tggccctctt tgcttccttt      300

tcccagaatc gttaagcccc gactcccact agcacctcgt accaacctcg ccccacccca      360

tcctcctgcc ttcccgcgct ccggtgtccc ccgctgccat gagctccccc atcagcaaga      420

gccgctcgct tgccgccttc ctgcagcagc tgcgcagtcc gaggcagccc ccgagactgg      480

tgacatctac ggcgtacacg tcccctcagc cgcgagaggt gccagtctgc ccgctgacag      540

ctggtggcga gactcagaac gcggccgccc tgccgggccc caccagctgg ccactgctgg      600

gcagcctgct gcagattctc tggaaagggg gtctcaagaa acagcacgac accctggtgg      660

agtaccacaa gaagtatggc aagattttcc gcatgaagtt gggttccttt gagtcggtgc      720

acctgggctc gccatgcctg ctggaagcgc tgtaccgcac cgagagcgcg tacccgcagc      780

ggctggagat caaaccgtgg aaggcctatc gcgactaccg caaagaaggc tacgggctgc      840

tgatcctgga aggggaagac tggcagcggg tccggagtgc ctttcaaaag aaactaatga      900

aaccagggga agtgatgaag ctggacaaca aaatcaatga ggtcttggcc gattttatgg      960

gcagaataga tgagctctgt gatgaaagag gccacgttga agacttgtac agcgaactga     1020

acaaatggtc gtttgaaagt atctgcctcg tgttgtatga gaagagattt gggcttctcc     1080

agaagaatgc aggggatgaa gctgtgaact tcatcatggc catcaaaaca atgatgagca     1140

cgtttgggag gatgatggtc actccagtcg agctgcacaa gagcctcaac accaaggtct     1200

ggcaggacca cactctggcc tgggacacca ttttcaaatc agtcaaagct tgtatcgaca     1260

accggttaga gaagtattct cagcagccta gtgcagattt cctttgtgac atttatcacc     1320

agaatcggct ttcaaagaaa gaattgtatg ctgctgtcac agagctccag ctggctgcgg     1380

tggaaacgac agcaaacagt ctaatgtgga ttctctacaa tttatcccgt aatccccaag     1440

tgcaacaaaa gcttcttaag gaaattcaaa gtgtattacc tgagaatcag gtgccacggg     1500

cagaagattt gaggaatatg ccgtatttaa aagcctgtct gaaagaatct atgaggctta     1560

cgccgagtgt accatttaca actcggactc ttgacaaggc aacagttctg ggtgaatatg     1620

ctttacccaa aggaacagtg ctcatgctaa atacccaggt gttgggatcc agtgaagaca     1680

attttgaaga ttcaagtcag tttagacctg aacgttggct tcaggagaag gaaaaaatta     1740

atccttttgc gcatcttcca tttggcgttg gaaaaagaat gtgcattggt cgccgattag     1800

cagagcttca actgcatttg gctctttgtt ggattgtccg caaatacgac atccaggcca     1860

cagacaatga gcctgttgag atgctacact caggcaccct ggtgcccagc cgggaactcc     1920

ccatcgcgtt ttgccagcga taatacgcct cagatggtgg tatttgctaa catcatatcc     1980

aactcaggga agcggactga gtgctgggat ccaaggcatt ctacagggtt cactgctggt     2040

ttacacttca cctgtgtcag caccatcttc aggtgcttag aatggcctgg gagcctgttc     2100

tgtcttgcat cttccatgac atgaaaggga ggctggcact tgtcagtcag gtagaggtta     2160

caaaccgttt caggccctgc ctaccacatt cactgtttga atctttaatt cccaagaata     2220

agtttacatt tcacaatgaa tgacctacaa cagctaaatt ttctggggct gggagtaata     2280

ctgacaatcc atttactgta gctctgctta atgtactact taggaaaatg tccctgctta     2340

ataatgtaag ccaagctaaa tgatggttaa agttatcagg cctcccatga aattgcgttc     2400

ttcctgcatt gaaataaaaa cattattggg aaactagaga acacctctat ttttaaaagg     2460

actttaacga agtcaaacaa cttataagac tagtgattca ctggggcatt attttgttag     2520

aggaccttaa aattgtttat tttttaaatg tgattccttt atggcattag ggtaaagatg     2580

aagcaataat ttttaaattg tgtatgtgca tatgaagcac agacatgcat gtgtgtgtgt     2640

gtctgtgtgt gtgtgtccgt gtatgtgtgt gtgggttcta atggtaattt gcctcagtca     2700

tttttttaat atttgcagta cttgatttag gatctgtggt gcagggcaat gtttcaaagt     2760

ttagtcacag cttaaaaaca ttcagtgtga ctttaatatt ataaaatgat ttcccatgcc     2820

ataatttttc tgtctattaa atgggacaag tgtaaagcat gcaaaagtta gagatctgtt     2880

atataacatt tgttttgtga tttgaactcc taggaaaaat atgatttcat aaatgtaaaa     2940

tgcacagaaa tgcatgcaat acttataaga cttaaaaatt gtgtttacag atggtttatt     3000

tgtgcatatt tttactactg cttttcctaa atgcatactg tatataattc tgtgtatttg     3060

ataaatattt cttcctacat tatattttta gaatatttca gaaatataca tttatgtctt     3120

tatattgtaa taaatatgta catatctagg tatatgcttt ctctctgctg tgaaattatt     3180

tttagaatta taaattcacg tcttgtcaga tttcatctgt ataccttcaa attctctgaa     3240

agtaaaaata aaagttttta aatattaaaa aaaaaaaaaa aaaaaaa                   3287


<210>  58
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ser Ser Pro Ile Ser Lys Ser Arg Ser Leu Ala Ala Phe Leu Gln 
1               5                   10                  15      


Gln Leu Arg Ser Pro Arg Gln Pro Pro Arg Leu Val Thr Ser Thr Ala 
            20                  25                  30          


Tyr Thr Ser Pro Gln Pro Arg Glu Val Pro Val Cys Pro Leu Thr Ala 
        35                  40                  45              


Gly Gly Glu Thr Gln Asn Ala Ala Ala Leu Pro Gly Pro Thr Ser Trp 
    50                  55                  60                  


Pro Leu Leu Gly Ser Leu Leu Gln Ile Leu Trp Lys Gly Gly Leu Lys 
65                  70                  75                  80  


Lys Gln His Asp Thr Leu Val Glu Tyr His Lys Lys Tyr Gly Lys Ile 
                85                  90                  95      


Phe Arg Met Lys Leu Gly Ser Phe Glu Ser Val His Leu Gly Ser Pro 
            100                 105                 110         


Cys Leu Leu Glu Ala Leu Tyr Arg Thr Glu Ser Ala Tyr Pro Gln Arg 
        115                 120                 125             


Leu Glu Ile Lys Pro Trp Lys Ala Tyr Arg Asp Tyr Arg Lys Glu Gly 
    130                 135                 140                 


Tyr Gly Leu Leu Ile Leu Glu Gly Glu Asp Trp Gln Arg Val Arg Ser 
145                 150                 155                 160 


Ala Phe Gln Lys Lys Leu Met Lys Pro Gly Glu Val Met Lys Leu Asp 
                165                 170                 175     


Asn Lys Ile Asn Glu Val Leu Ala Asp Phe Met Gly Arg Ile Asp Glu 
            180                 185                 190         


Leu Cys Asp Glu Arg Gly His Val Glu Asp Leu Tyr Ser Glu Leu Asn 
        195                 200                 205             


Lys Trp Ser Phe Glu Ser Ile Cys Leu Val Leu Tyr Glu Lys Arg Phe 
    210                 215                 220                 


Gly Leu Leu Gln Lys Asn Ala Gly Asp Glu Ala Val Asn Phe Ile Met 
225                 230                 235                 240 


Ala Ile Lys Thr Met Met Ser Thr Phe Gly Arg Met Met Val Thr Pro 
                245                 250                 255     


Val Glu Leu His Lys Ser Leu Asn Thr Lys Val Trp Gln Asp His Thr 
            260                 265                 270         


Leu Ala Trp Asp Thr Ile Phe Lys Ser Val Lys Ala Cys Ile Asp Asn 
        275                 280                 285             


Arg Leu Glu Lys Tyr Ser Gln Gln Pro Ser Ala Asp Phe Leu Cys Asp 
    290                 295                 300                 


Ile Tyr His Gln Asn Arg Leu Ser Lys Lys Glu Leu Tyr Ala Ala Val 
305                 310                 315                 320 


Thr Glu Leu Gln Leu Ala Ala Val Glu Thr Thr Ala Asn Ser Leu Met 
                325                 330                 335     


Trp Ile Leu Tyr Asn Leu Ser Arg Asn Pro Gln Val Gln Gln Lys Leu 
            340                 345                 350         


Leu Lys Glu Ile Gln Ser Val Leu Pro Glu Asn Gln Val Pro Arg Ala 
        355                 360                 365             


Glu Asp Leu Arg Asn Met Pro Tyr Leu Lys Ala Cys Leu Lys Glu Ser 
    370                 375                 380                 


Met Arg Leu Thr Pro Ser Val Pro Phe Thr Thr Arg Thr Leu Asp Lys 
385                 390                 395                 400 


Ala Thr Val Leu Gly Glu Tyr Ala Leu Pro Lys Gly Thr Val Leu Met 
                405                 410                 415     


Leu Asn Thr Gln Val Leu Gly Ser Ser Glu Asp Asn Phe Glu Asp Ser 
            420                 425                 430         


Ser Gln Phe Arg Pro Glu Arg Trp Leu Gln Glu Lys Glu Lys Ile Asn 
        435                 440                 445             


Pro Phe Ala His Leu Pro Phe Gly Val Gly Lys Arg Met Cys Ile Gly 
    450                 455                 460                 


Arg Arg Leu Ala Glu Leu Gln Leu His Leu Ala Leu Cys Trp Ile Val 
465                 470                 475                 480 


Arg Lys Tyr Asp Ile Gln Ala Thr Asp Asn Glu Pro Val Glu Met Leu 
                485                 490                 495     


His Ser Gly Thr Leu Val Pro Ser Arg Glu Leu Pro Ile Ala Phe Cys 
            500                 505                 510         


Gln Arg 
        


<210>  59
<211>  914
<212>  DNA
<213>  Homo sapiens

<400>  59
gcatggggag gggcggccct caaacgggtc attgccatta atagagacct caaacaccgc       60

ctgctaaaaa tacccgactg gaggagcata aaagcgcagc cgagcccagc gccccgcact      120

tttctgagca gacgtccaga gcagagtcag ccagcatgac cgagcgccgc gtccccttct      180

cgctcctgcg gggccccagc tgggacccct tccgcgactg gtacccgcat agccgcctct      240

tcgaccaggc cttcgggctg ccccggctgc cggaggagtg gtcgcagtgg ttaggcggca      300

gcagctggcc aggctacgtg cgccccctgc cccccgccgc catcgagagc cccgcagtgg      360

ccgcgcccgc ctacagccgc gcgctcagcc ggcaactcag cagcggggtc tcggagatcc      420

ggcacactgc ggaccgctgg cgcgtgtccc tggatgtcaa ccacttcgcc ccggacgagc      480

tgacggtcaa gaccaaggat ggcgtggtgg agatcaccgg caagcacgag gagcggcagg      540

acgagcatgg ctacatctcc cggtgcttca cgcggaaata cacgctgccc cccggtgtgg      600

accccaccca agtttcctcc tccctgtccc ctgagggcac actgaccgtg gaggccccca      660

tgcccaagct agccacgcag tccaacgaga tcaccatccc agtcaccttc gagtcgcggg      720

cccagcttgg gggcccagaa gctgcaaaat ccgatgagac tgccgccaag taaagcctta      780

gcccggatgc ccacccctgc tgccgccact ggctgtgcct cccccgccac ctgtgtgttc      840

ttttgataca tttatcttct gtttttctca aataaagttc aaagcaacca cctgtcaaaa      900

aaaaaaaaaa aaaa                                                        914


<210>  60
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp 
1               5                   10                  15      


Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala 
            20                  25                  30          


Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly 
        35                  40                  45              


Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu 
    50                  55                  60                  


Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln 
65                  70                  75                  80  


Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg 
                85                  90                  95      


Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys 
            100                 105                 110         


Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln 
        115                 120                 125             


Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu 
145                 150                 155                 160 


Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser 
                165                 170                 175     


Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly 
            180                 185                 190         


Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys 
        195                 200                 205 


<210>  61
<211>  3965
<212>  DNA
<213>  Homo sapiens

<400>  61
gggggagggt atataagccg agtaggcgac ggtgaggtcg acgccggcca agacagcaca       60

gacagattga cctattgggg tgtttcgcga gtgtgagagg gaagcgccgc ggcctgtatt      120

tctagacctg cccttcgcct ggttcgtggc gccttgtgac cccgggcccc tgccgcctgc      180

aagtcggaaa ttgcgctgtg ctcctgtgct acggcctgtg gctggactgc ctgctgctgc      240

ccaactggct ggcaagatga agctctccct ggtggccgcg atgctgctgc tgctcagcgc      300

ggcgcgggcc gaggaggagg acaagaagga ggacgtgggc acggtggtcg gcatcgacct      360

ggggaccacc tactcctgcg tcggcgtgtt caagaacggc cgcgtggaga tcatcgccaa      420

cgatcagggc aaccgcatca cgccgtccta tgtcgccttc actcctgaag gggaacgtct      480

gattggcgat gccgccaaga accagctcac ctccaacccc gagaacacgg tctttgacgc      540

caagcggctc atcggccgca cgtggaatga cccgtctgtg cagcaggaca tcaagttctt      600

gccgttcaag gtggttgaaa agaaaactaa accatacatt caagttgata ttggaggtgg      660

gcaaacaaag acatttgctc ctgaagaaat ttctgccatg gttctcacta aaatgaaaga      720

aaccgctgag gcttatttgg gaaagaaggt tacccatgca gttgttactg taccagccta      780

ttttaatgat gcccaacgcc aagcaaccaa agacgctgga actattgctg gcctaaatgt      840

tatgaggatc atcaacgagc ctacggcagc tgctattgct tatggcctgg ataagaggga      900

gggggagaag aacatcctgg tgtttgacct gggtggcgga accttcgatg tgtctcttct      960

caccattgac aatggtgtct tcgaagttgt ggccactaat ggagatactc atctgggtgg     1020

agaagacttt gaccagcgtg tcatggaaca cttcatcaaa ctgtacaaaa agaagacggg     1080

caaagatgtc aggaaagaca atagagctgt gcagaaactc cggcgcgagg tagaaaaggc     1140

caaacgggcc ctgtcttctc agcatcaagc aagaattgaa attgagtcct tctatgaagg     1200

agaagacttt tctgagaccc tgactcgggc caaatttgaa gagctcaaca tggatctgtt     1260

ccggtctact atgaagcccg tccagaaagt gttggaagat tctgatttga agaagtctga     1320

tattgatgaa attgttcttg ttggtggctc gactcgaatt ccaaagattc agcaactggt     1380

taaagagttc ttcaatggca aggaaccatc ccgtggcata aacccagatg aagctgtagc     1440

gtatggtgct gctgtccagg ctggtgtgct ctctggtgat caagatacag gtgacctggt     1500

actgcttgat gtatgtcccc ttacacttgg tattgaaact gtgggaggtg tcatgaccaa     1560

actgattcca aggaacacag tggtgcctac caagaagtct cagatctttt ctacagcttc     1620

tgataatcaa ccaactgtta caatcaaggt ctatgaaggt gaaagacccc tgacaaaaga     1680

caatcatctt ctgggtacat ttgatctgac tggaattcct cctgctcctc gtggggtccc     1740

acagattgaa gtcacctttg agatagatgt gaatggtatt cttcgagtga cagctgaaga     1800

caagggtaca gggaacaaaa ataagatcac aatcaccaat gaccagaatc gcctgacacc     1860

tgaagaaatc gaaaggatgg ttaatgatgc tgagaagttt gctgaggaag acaaaaagct     1920

caaggagcgc attgatacta gaaatgagtt ggaaagctat gcctattctc taaagaatca     1980

gattggagat aaagaaaagc tgggaggtaa actttcctct gaagataagg agaccatgga     2040

aaaagctgta gaagaaaaga ttgaatggct ggaaagccac caagatgctg acattgaaga     2100

cttcaaagct aagaagaagg aactggaaga aattgttcaa ccaattatca gcaaactcta     2160

tggaagtgca ggccctcccc caactggtga agaggataca gcagaaaaag atgagttgta     2220

gacactgatc tgctagtgct gtaatattgt aaatactgga ctcaggaact tttgttagga     2280

aaaaattgaa agaacttaag tctcgaatgt aattggaatc ttcacctcag agtggagttg     2340

aaactgctat agcctaagcg gctgtttact gcttttcatt agcagttgct cacatgtctt     2400

tgggtggggg ggagaagaag aattggccat cttaaaaagc gggtaaaaaa cctgggttag     2460

ggtgtgtgtt caccttcaaa atgttctatt taacaactgg gtcatgtgca tctggtgtag     2520

gaagtttttt ctaccataag tgacaccaat aaatgtttgt tatttacact ggtctaatgt     2580

ttgtgagaag cttctaatta gatcaattac ttattttagg aaatttaaga ctagatactc     2640

gtgtgtgggg tgaggggagg gagtatttgg tatgttggga taaggaaaca cttctattta     2700

atgcttccag ggattttttt tttttttttt aaccctcctg ggcccaagtg atccttccac     2760

ctcagtctcc cagctaattg agaccacagg cttgttacca ccatgctcgg cttttgcatt     2820

aatctaagaa aaggggagag aagttaatcc acatctttac tcaggcaagg ggcatttcac     2880

agtgcccaag agtggggttt tcttgaacat acttggtttc ctatttcccc ttatctttct     2940

aaaactgcct ttctggtggc tttttttaaa attattacta atgatgcttt tatagctgct     3000

tggattctct gagaaatgat ggggagtgag tgatcactgg tattaacttt atacacttgg     3060

atttcatttg taactttagg atgtaaaggt atattgtgaa ccctagctgt gtcagaatct     3120

ccatccctga aatttctcat tagtggtact ggggtgggat cttggatggt gacattgaaa     3180

ctacactaaa tcccctcact atgaatgggt tgttaaaggc aatggtttgt gtcaaaactg     3240

gtttaggatt acttagattg tgttcctgaa gaaaagagtc caggtaaatg gtatgatcaa     3300

taaaggacag gctggtgcta acataaaatc caatattgta atcctagcac tttgggaggc     3360

caaggcgggt ggatcacaag gtcaagagat agagaccatc tttgccaaca tggtgaaact     3420

ccatctctac tgaaaataca aaaattagct gggcgtggta gtgcaagctg aaggctgagg     3480

caggagaatc actcgaaccc gggaggcaga ggttgcagtg agccgagatc acaccactgt     3540

actccagccc ggcactccag cctggcgaca agagtgagac tccacctcaa aaaaaaaaaa     3600

aagaatccaa tactgcccaa ggataggtat tttatagatg ggcaactggc tgaaaggtta     3660

attctctagg gctagtagaa ctggatccca acaccaaact cttaattaga cctaggcctc     3720

agctgcactg cccgaaaagc atttgggcag accctgagca gaatactggt ctcaggccaa     3780

gcccaataca gccattaaag atgacctaca gtgctgtgta ccctggggca atagggttaa     3840

atggtagtta gcaactaggg ctagtcttcc cttacctcaa aggctctcac taccgtggac     3900

cacctagtct gtaactcttt ctgaggagct gttactgaat attaaaaaga tagacttcaa     3960

ctatg                                                                 3965


<210>  62
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 
            20                  25                  30          


Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 
        35                  40                  45              


Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser 
    50                  55                  60                  


Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 
65                  70                  75                  80  


Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 
                85                  90                  95      


Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 
            100                 105                 110         


Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 
        115                 120                 125             


Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 
    130                 135                 140                 


Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 
145                 150                 155                 160 


Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 
                165                 170                 175     


Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 
            180                 185                 190         


Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 
        195                 200                 205             


Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 
    210                 215                 220                 


Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 
225                 230                 235                 240 


Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 
                245                 250                 255     


Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 
            260                 265                 270         


Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 
        275                 280                 285             


Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 
    290                 295                 300                 


Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 
305                 310                 315                 320 


Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 
                325                 330                 335     


Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 
            340                 345                 350         


Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 
        355                 360                 365             


Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 
    370                 375                 380                 


Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu 
                405                 410                 415     


Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 
            420                 425                 430         


Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 
        435                 440                 445             


Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 
    450                 455                 460                 


Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 
465                 470                 475                 480 


Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
                485                 490                 495     


Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 
            500                 505                 510         


Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 
        515                 520                 525             


Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 
    530                 535                 540                 


Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 
545                 550                 555                 560 


Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 
                565                 570                 575     


Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 
            580                 585                 590         


Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 
        595                 600                 605             


Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 
    610                 615                 620                 


Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 
625                 630                 635                 640 


Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
                645                 650                 


<210>  63
<211>  7370
<212>  DNA
<213>  Homo sapiens

<400>  63
ttttgtagat aaatgtgagg attttctcta aatccctctt ctgtttgcta aatctcactg       60

tcactgctaa attcagagca gatagagcct gcgcaatgga ataaagtcct caaaattgaa      120

atgtgacatt gctctcaaca tctcccatct ctctggattt ctttttgctt cattattcct      180

gctaaccaat tcattttcag actttgtact tcagaagcaa tgggaaaaat cagcagtctt      240

ccaacccaat tatttaagtg ctgcttttgt gatttcttga aggtgaagat gcacaccatg      300

tcctcctcgc atctcttcta cctggcgctg tgcctgctca ccttcaccag ctctgccacg      360

gctggaccgg agacgctctg cggggctgag ctggtggatg ctcttcagtt cgtgtgtgga      420

gacaggggct tttatttcaa caagcccaca gggtatggct ccagcagtcg gagggcgcct      480

cagacaggca tcgtggatga gtgctgcttc cggagctgtg atctaaggag gctggagatg      540

tattgcgcac ccctcaagcc tgccaagtca gctcgctctg tccgtgccca gcgccacacc      600

gacatgccca agacccagaa gtatcagccc ccatctacca acaagaacac gaagtctcag      660

agaaggaaag gaagtacatt tgaagaacgc aagtagaggg agtgcaggaa acaagaacta      720

caggatgtag gaagaccctc ctgaggagtg aagagtgaca tgccaccgca ggatcctttg      780

ctctgcacga gttacctgtt aaactttgga acacctacca aaaaataagt ttgataacat      840

ttaaaagatg ggcgtttccc ccaatgaaat acacaagtaa acattccaac attgtcttta      900

ggagtgattt gcaccttgca aaaatggtcc tggagttggt agattgctgt tgatctttta      960

tcaataatgt tctatagaaa agaaaaaaaa aatatatata tatatatatc ttagtccctg     1020

cctctcaaga gccacaaatg catgggtgtt gtatagatcc agttgcacta aattcctctc     1080

tgaatcttgg ctgctggagc cattcattca gcaaccttgt ctaagtggtt tatgaattgt     1140

ttccttattt gcacttcttt ctacacaact cgggctgttt gttttacagt gtctgataat     1200

cttgttagtc tatacccacc acctcccttc ataaccttta tatttgccga atttggcctc     1260

ctcaaaagca gcagcaagtc gtcaagaagc acaccaattc taacccacaa gattccatct     1320

gtggcatttg taccaaatat aagttggatg cattttattt tagacacaaa gctttatttt     1380

tccacatcat gcttacaaaa aagaataatg caaatagttg caactttgag gccaatcatt     1440

tttaggcata tgttttaaac atagaaagtt tcttcaactc aaaagagttc cttcaaatga     1500

tgagttaatg tgcaacctaa ttagtaactt tcctcttttt attttttcca tatagagcac     1560

tatgtaaatt tagcatatca attatacagg atatatcaaa cagtatgtaa aactctgttt     1620

tttagtataa tggtgctatt ttgtagtttg ttatatgaaa gagtctggcc aaaacggtaa     1680

tacgtgaaag caaaacaata ggggaagcct ggagccaaag atgacacaag gggaagggta     1740

ctgaaaacac catccatttg ggaaagaagg caaagtcccc ccagttatgc cttccaagag     1800

gaacttcaga cacaaaagtc cactgatgca aattggactg gcgagtccag agaggaaact     1860

gtggaatgga aaaagcagaa ggctaggaat tttagcagtc ctggtttctt tttctcatgg     1920

aagaaatgaa catctgccag ctgtgtcatg gactcaccac tgtgtgacct tgggcaagtc     1980

acttcacctc tctgtgcctc agtttcctca tctgcaaaat gggggcaata tgtcatctac     2040

ctacctcaaa ggggtggtat aaggtttaaa aagataaaga ttcagatttt ttttaccctg     2100

ggttgctgta agggtgcaac atcagggcgc ttgagttgct gagatgcaag gaattctata     2160

aataacccat tcatagcata gctagagatt ggtgaattga atgctcctga catctcagtt     2220

cttgtcagtg aagctatcca aataactggc caactagttg ttaaaagcta acagctcaat     2280

ctcttaaaac acttttcaaa atatgtggga agcatttgat tttcaatttg attttgaatt     2340

ctgcatttgg ttttatgaat acaaagataa gtgaaaagag agaaaggaaa agaaaaagga     2400

gaaaaacaaa gagatttcta ccagtgaaag gggaattaat tactctttgt tagcactcac     2460

tgactcttct atgcagttac tacatatcta gtaaaacctc gtttaatact ataaataata     2520

ttctattcat tttgaaaaac acaatgattc cttcttttct aggcaatata aggaaagtga     2580

tccaaaattt gaaatattaa aataatatct aataaaaagt cacaaagtta tcttctttaa     2640

caaactttac tcttattctt agctgtatat acattttttt aaaagtttgt taaaatatgc     2700

ttgactagag tttccagttg aaaggcaaaa acttccatca caacaagaaa tttcccatgc     2760

ctgctcagaa gggtagcccc tagctctctg tgaatgtgtt ttatccattc aactgaaaat     2820

tggtatcaag aaagtccact ggttagtgta ctagtccatc atagcctaga aaatgatccc     2880

tatctgcaga tcaagatttt ctcattagaa caatgaatta tccagcattc agatctttct     2940

agtcacctta gaactttttg gttaaaagta cccaggcttg attatttcat gcaaattcta     3000

tattttacat tcttggaaag tctatatgaa aaacaaaaat aacatcttca gtttttctcc     3060

cactgggtca cctcaaggat cagaggccag gaaaaaaaaa aaaaagactc cctggatctc     3120

tgaatatatg caaaaagaag gccccattta gtggagccag caatcctgtt cagtcaacaa     3180

gtattttaac tctcagtcca acattatttg aattgagcac ctcaagcatg cttagcaatg     3240

ttctaatcac tatggacaga tgtaaaagaa actatacatc atttttgccc tctgcctgtt     3300

ttccagacat acaggttctg tggaataaga tactggactc ctcttcccaa gatggcactt     3360

ctttttattt cttgtcccca gtgtgtacct tttaaaatta ttccctctca acaaaacttt     3420

ataggcagtc ttctgcagac ttaacgtgtt ttctgtcata gttagatgtg ataattctaa     3480

gagtgtctat gacttatttc cttcacttaa ttctatccac agtcaaaaat cccccaagga     3540

ggaaagctga aagatgcact gccatattat ctttcttaac tttttccaac acataatcct     3600

ctccaactgg attataaata aattgaaaat aactcattat accaattcac tattttattt     3660

tttaatgaat taaaactaga aaacaaattg atgcaaaccc tggaagtcag ttgattacta     3720

tatactacag cagaatgact cagatttcat agaaaggagc aaccaaaatg tcacaaccca     3780

aaactttaca agctttgctt cagaattaga ttgctttata attcttgaat gaggcaattt     3840

caagatattt gtaaaagaac agtaaacatt ggtaagaatg agctttcaac tcataggctt     3900

atttccaatt taattgacca tactggatac ttaggtcaaa tttctgttct ctcttcccca     3960

aataatatta aagtattatt tgaacttttt aagatgaggc agttcccctg aaaaagttaa     4020

tgcagctctc catcagaatc cactcttcta gggatatgaa aatctcttaa cacccaccct     4080

acatacacag acacacacac acacacacac acacacacac acacacacat tcaccctaag     4140

gatccaatgg aatactgaaa agaaatcact tccttgaaaa ttttattaaa aaacaaacaa     4200

acaaacaaaa agcctgtcca cccttgagaa tccttcctct ccttggaacg tcaatgtttg     4260

tgtagatgaa accatctcat gctctgtggc tccagggttt ctgttactat tttatgcact     4320

tgggagaagg cttagaataa aagatgtagc acattttgct ttcccattta ttgtttggcc     4380

agctatgcca atgtggtgct attgtttctt taagaaagta cttgactaaa aaaaaaagaa     4440

aaaaagaaaa aaaagaaagc atagacatat ttttttaaag tataaaaaca acaattctat     4500

agatagatgg cttaataaaa tagcattagg tctatctagc caccaccacc tttcaacttt     4560

ttatcactca caagtagtgt actgttcacc aaattgtgaa tttgggggtg caggggcagg     4620

agttggaaat tttttaaagt tagaaggctc cattgttttg ttggctctca aacttagcaa     4680

aattagcaat atattatcca atcttctgaa cttgatcaag agcatggaga ataaacgcgg     4740

gaaaaaagat cttataggca aatagaagaa tttaaaagat aagtaagttc cttattgatt     4800

tttgtgcact ctgctctaaa acagatattc agcaagtgga gaaaataaga acaaagagaa     4860

aaaatacata gatttacctg caaaaaatag cttctgccaa atcccccttg ggtattcttt     4920

ggcatttact ggtttataga agacattctc ccttcaccca gacatctcaa agagcagtag     4980

ctctcatgaa aagcaatcac tgatctcatt tgggaaatgt tggaaagtat ttccttatga     5040

gatgggggtt atctactgat aaagaaagaa tttatgagaa attgttgaaa gagatggcta     5100

acaatctgtg aagatttttt gtttcttgtt tttgtttttt tttttttttt actttataca     5160

gtctttatga atttcttaat gttcaaaatg acttggttct tttcttcttt ttttatatca     5220

gaatgaggaa taataagtta aacccacata gactctttaa aactataggc tagatagaaa     5280

tgtatgtttg acttgttgaa gctataatca gactatttaa aatgttttgc tatttttaat     5340

cttaaaagat tgtgctaatt tattagagca gaacctgttt ggctctcctc agaagaaaga     5400

atctttccat tcaaatcaca tggctttcca ccaatatttt caaaagataa atctgattta     5460

tgcaatggca tcatttattt taaaacagaa gaattgtgaa agtttatgcc cctcccttgc     5520

aaagaccata aagtccagat ctggtagggg ggcaacaaca aaaggaaaat gttgttgatt     5580

cttggttttg gattttgttt tgttttcaat gctagtgttt aatcctgtag tacatatttg     5640

cttattgcta ttttaatatt ttataagacc ttcctgttag gtattagaaa gtgatacata     5700

gatatctttt ttgtgtaatt tctatttaaa aaagagagaa gactgtcaga agctttaagt     5760

gcatatggta caggataaag atatcaattt aaataaccaa ttcctatctg gaacaatgct     5820

tttgtttttt aaagaaacct ctcacagata agacagaggc ccaggggatt tttgaagctg     5880

tctttattct gcccccatcc caacccagcc cttattattt tagtatctgc ctcagaattt     5940

tatagagggc tgaccaagct gaaactctag aattaaagga acctcactga aaacatatat     6000

ttcacgtgtt ccctcttttt ttttttcctt tttgtgagat ggggtctcgc actgtccccc     6060

aggctggagt gcagtggcat gatctcggct cactgcaacc tccacctcct gggtttaagc     6120

gattctcctg cctcagcctc ctgagtagct gggattacag gcacccacca ctatgcccgg     6180

ctaatttttt ggatttttaa tagagacggg gttttaccat gttggccagg ttggtctcaa     6240

actcctgacc ttgtgatttg cccgcctcag cctcccaaat tgctgggatt acaggcatga     6300

gccaccacac cctgcccatg tgttccctct taatgtatga ttacatggat cttaaacatg     6360

atccttctct cctcattctt caactatctt tgatggggtc tttcaagggg aaaaaaatcc     6420

aagctttttt aaagtaaaaa aaaaaaaaga gaggacacaa aaccaaatgt tactgctcaa     6480

ctgaaatatg agttaagatg gagacagagt ttctcctaat aaccggagct gaattacctt     6540

tcactttcaa aaacatgacc ttccacaatc cttagaatct gccttttttt atattactga     6600

ggcctaaaag taaacattac tcattttatt ttgcccaaaa tgcactgatg taaagtagga     6660

aaaataaaaa cagagctcta aaatcccttt caagccaccc attgacccca ctcaccaact     6720

catagcaaag tcacttctgt taatccctta atctgatttt gtttggatat ttatcttgta     6780

cccgctgcta aacacactgc aggagggact ctgaaacctc aagctgtcta cttacatctt     6840

ttatctgtgt ctgtgtatca tgaaaatgtc tattcaaaat atcaaaacct ttcaaatatc     6900

acgcagctta tattcagttt acataaaggc cccaaatacc atgtcagatc tttttggtaa     6960

aagagttaat gaactatgag aattgggatt acatcatgta ttttgcctca tgtattttta     7020

tcacacttat aggccaagtg tgataaataa acttacagac actgaattaa tttcccctgc     7080

tactttgaaa ccagaaaata atgactggcc attcgttaca tctgtcttag ttgaaaagca     7140

tattttttat taaattaatt ctgattgtat ttgaaattat tattcaattc acttatggca     7200

gaggaatatc aatcctaatg acttctaaaa atgtaactaa ttgaatcatt atcttacatt     7260

tactgtttaa taagcatatt ttgaaaatgt atggctagag tgtcataata aaatggtata     7320

tctttcttta gtaattacat taaaattagt catgtttgat taattagttc                7370


<210>  64
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 
    130                 135                 140                 


Lys Ser Gln Arg Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 
145                 150                 155             


<210>  65
<211>  5156
<212>  DNA
<213>  Homo sapiens

<400>  65
ccgctaatgt accatgccct ggtgctggaa agtgcctgag ccagctgccc cagcggcctc       60

agcactacca agttggcaca aagctcccca aattcggagg ggctcaggga aacgagtgga      120

ggggatgagg aggtgagggg taaacccatc atttcagttg gcatttgagc aggtgccatg      180

ctcagcggag atgaggctct cccatctgta ggggccgtat taacatgcac actctaaaag      240

tgcccttcgt ttctccagcc tcagctttgt ccctctcctc ctccacgtca acctggccag      300

agggtctgga cgccacagcc agggcacccc ctgctttggt ggtgactgct aatattggcc      360

aggccggcgg atcatcgtcc aggcagtttc ggcagagagc cttgggcacc agtgactccc      420

cggtcctctt tatccactgt ccaggagctg cggggactgc gcagggacta gagtacaggg      480

gccgaagagt caccaccgag cttgtgtggg aggaggtgga ttccagcccc cagccccagg      540

gctctgaatc gctgccagct cagccccctg cccagcctgc cccacagcct gagccccagc      600

aggccagaga gcccagtcct gaggtgagct gctgtggcct gtggcccagg cgaccccagc      660

gctcccagaa ctgaggctgg cagccagccc cagcctcagc cccaactgcg aggcagagag      720

acaccaatgg gaatcccaat ggggaagtcg atgctggtgc ttctcacctt cttggccttc      780

gcctcgtgct gcattgctgc ttaccgcccc agtgagaccc tgtgcggcgg ggagctggtg      840

gacaccctcc agttcgtctg tggggaccgc ggcttctact tcagcaggcc cgcaagccgt      900

gtgagccgtc gcagccgtgg catcgttgag gagtgctgtt tccgcagctg tgacctggcc      960

ctcctggaga cgtactgtgc tacccccgcc aagtccgaga gggacgtgtc gacccctccg     1020

accgtgcttc cggacaactt ccccagatac cccgtgggca agttcttcca atatgacacc     1080

tggaagcagt ccacccagcg cctgcgcagg ggcctgcctg ccctcctgcg tgcccgccgg     1140

ggtcacgtgc tcgccaagga gctcgaggcg ttcagggagg ccaaacgtca ccgtcccctg     1200

attgctctac ccacccaaga ccccgcccac gggggcgccc ccccagagat ggccagcaat     1260

cggaagtgag caaaactgcc gcaagtctgc agcccggcgc caccatcctg cagcctcctc     1320

ctgaccacgg acgtttccat caggttccat cccgaaaatc tctcggttcc acgtccccct     1380

ggggcttctc ctgacccagt ccccgtgccc cgcctccccg aaacaggcta ctctcctcgg     1440

ccccctccat cgggctgagg aagcacagca gcatcttcaa acatgtacaa aatcgattgg     1500

ctttaaacac ccttcacata ccctcccccc aaattatccc caattatccc cacacataaa     1560

aaatcaaaac attaaactaa cccccttccc ccccccccac aacaaccctc ttaaaactaa     1620

ttggcttttt agaaacaccc cacaaaagct cagaaattgg ctttaaaaaa aacaaccacc     1680

aaaaaaaatc aattggctaa aaaaaaaaag tattaaaaac gaattggctg agaaacaatt     1740

ggcaaaataa aggaatttgg cactccccac ccccctcttt ctcttctccc ttggactttg     1800

agtcaaattg gcctggactt gagtccctga accagcaaag agaaaagaag gaccccagaa     1860

atcacaggtg ggcacgtcgc tgctaccgcc atctcccttc tcacgggaat tttcagggta     1920

aactggccat ccgaaaatag caacaaccca gactggctcc tcactccctt ttccatcact     1980

aaaaatcaca gagcagtcag agggacccag taagaccaaa ggaggggagg acagagcatg     2040

aaaaccaaaa tccatgcaaa tgaaatgtaa ttggcacgac cctcaccccc aaatcttaca     2100

tctcaattcc catcctaaaa agcactcata ctttatgcat ccccgcagct acacacacac     2160

aacacacagc acacgcatga acacagcaca cacacgagca cagcacacac acaaacgcac     2220

agcacacaca gcacacagat gagcacacag cacacacaca aacgcacagc acacacacgc     2280

acacacatgc acacacagca cacaaacgca cggcacacac acgcacacac atgcacacac     2340

agcacacaca caaacgcaca gcacacacaa acgcacagca cacacgcaca cacagcacac     2400

acacgagcac acagcacaca aacgcacagc acacgcacac acatgcacac acagcacaca     2460

cactagcaca cagcacacac acaaagacac agcacacaca tgcacacaca gcacacacac     2520

gcgaacacag cacacacgaa cacagcacac acagcacaca cacaaacaca gcacacacat     2580

gcacacagca cacgcacaca cagcacacac atgaacacag cacacagcac acacatgcac     2640

acacagcaca cacgcatgca cagcacacat gaacacagca cacacacaaa cacacagcac     2700

acacatgcac acacagcaca cacactcatg cgcagcacat acatgaacac agctcacagc     2760

acacaaacac gcagcacaca cgttgcacac gcaagcaccc acctgcacac acacatgcgc     2820

acacacacgc acacccccac aaaattggat gaaaacaata agcatatcta agcaactacg     2880

atatctgtat ggatcaggcc aaagtcccgc taagattctc caatgttttc atggtctgag     2940

ccccgctcct gttcccatct ccactgcccc tcggccctgt ctgtgccctg cctctcagag     3000

gagggggctc agatggtgcg gcctgagtgt gcggccggcg gcatttggga tacacccgta     3060

gggtgggcgg ggtgtgtccc aggcctaatt ccatctttcc accatgacag agatgccctt     3120

gtgaggctgg cctccttggc gcctgtcccc acggcccccg cagcgtgagc cacgatgctc     3180

cccatacccc acccattccc gatacacctt acttactgtg tgttggccca gccagagtga     3240

ggaaggagtt tggccacatt ggagatggcg gtagctgagc agacatgccc ccacgagtag     3300

cctgactccc tggtgtgctc ctggaaggaa gatcttgggg acccccccac cggagcacac     3360

ctagggatca tctttgcccg tctcctgggg accccccaag aaatgtggag tcctcggggg     3420

ccgtgcactg atgcggggag tgtgggaagt ctggcggttg gaggggtggg tggggggcag     3480

tgggggctgg gcggggggag ttctggggta ggaagtggtc ccgggagatt ttggatggaa     3540

aagtcaggag gattgacagc agacttgcag aattacatag agaaattagg aacccccaaa     3600

tttcatgtca attgatctat tccccctctt tgtttcttgg ggcatttttc cttttttttt     3660

tttttttgtt ttttttttac ccctccttag ctttatgcgc tcagaaacca aattaaaccc     3720

cccccccatg taacaggggg gcagtgacaa aagcaagaac gcacgaagcc agcctggaga     3780

ccaccacgtc ctgccccccg ccatttatcg ccctgattgg attttgtttt tcatctgtcc     3840

ctgttgcttg ggttgagttg agggtggagc ctcctggggg gcactggcca ctgagccccc     3900

ttggagaagt cagaggggag tggagaaggc cactgtccgg cctggcttct ggggacagtg     3960

gctggtcccc agaagtcctg agggcggagg ggggggttgg gcagggtctc ctcaggtgtc     4020

aggagggtgc tcggaggcca caggaggggg ctcctggctg gcctgaggct ggccggaggg     4080

gaaggggcta gcaggtgtgt aaacagaggg ttccatcagg ctggggcagg gtggccgcct     4140

tccgcacact tgaggaaccc tcccctctcc ctcggtgaca tcttgcccgc ccctcagcac     4200

cctgccttgt ctccaggagg tccgaagctc tgtgggacct cttgggggca aggtggggtg     4260

aggccgggga gtagggaggt caggcgggtc tgagcccaca gagcaggaga gctgccaggt     4320

ctgcccatcg accaggttgc ttgggccccg gagcccacgg gtctggtgat gccatagcag     4380

ccaccaccgc ggcgcctagg gctgcggcag ggactcggcc tctgggaggt ttacctcgcc     4440

cccacttgtg cccccagctc agcccccctg cacgcagccc gactagcagt ctagaggcct     4500

gaggcttctg ggtcctggtg acggggctgg catgaccccg ggggtcgtcc atgccagtcc     4560

gcctcagtcg cagagggtcc ctcggcaagc gccctgtgag tgggccattc ggaacattgg     4620

acagaagccc aaagagccaa attgtcacaa ttgtggaacc cacattggcc tgagatccaa     4680

aacgcttcga ggcaccccaa attacctgcc cattcgtcag gacacccacc cacccagtgt     4740

tatattctgc ctcgccggag tgggtgttcc cgggggcact tgccgaccag ccccttgcgt     4800

ccccaggttt gcagctctcc cctgggccac taaccatcct ggcccgggct gcctgtctga     4860

cctccgtgcc tagtcgtggc tctccatctt gtctcctccc cgtgtcccca atgtcttcag     4920

tggggggccc cctcttgggt cccctcctct gccatcacct gaagaccccc acgccaaaca     4980

ctgaatgtca cctgtgcctg ccgcctcggt ccaccttgcg gcccgtgttt gactcaactc     5040

aactccttta acgctaatat ttccggcaaa atcccatgct tgggttttgt ctttaacctt     5100

gtaacgcttg caatcccaat aaagcattaa aagtcatgaa aaaaaaaaaa aaaaaa         5156


<210>  66
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  67
<211>  1439
<212>  DNA
<213>  Homo sapiens

<400>  67
tgcggcggcg agggaggagg aagaagcgga ggaggcggct cccgcgctcg cagggccgtg       60

ccacctgccc gcccgcccgc tcgctcgctc gcccgccgcg ccgcgctgcc gaccgccagc      120

atgctgccga gagtgggctg ccccgcgctg ccgctgccgc cgccgccgct gctgccgctg      180

ctgccgctgc tgctgctgct actgggcgcg agtggcggcg gcggcggggc gcgcgcggag      240

gtgctgttcc gctgcccgcc ctgcacaccc gagcgcctgg ccgcctgcgg gcccccgccg      300

gttgcgccgc ccgccgcggt ggccgcagtg gccggaggcg cccgcatgcc atgcgcggag      360

ctcgtccggg agccgggctg cggctgctgc tcggtgtgcg cccggctgga gggcgaggcg      420

tgcggcgtct acaccccgcg ctgcggccag gggctgcgct gctatcccca cccgggctcc      480

gagctgcccc tgcaggcgct ggtcatgggc gagggcactt gtgagaagcg ccgggacgcc      540

gagtatggcg ccagcccgga gcaggttgca gacaatggcg atgaccactc agaaggaggc      600

ctggtggaga accacgtgga cagcaccatg aacatgttgg gcgggggagg cagtgctggc      660

cggaagcccc tcaagtcggg tatgaaggag ctggccgtgt tccgggagaa ggtcactgag      720

cagcaccggc agatgggcaa gggtggcaag catcaccttg gcctggagga gcccaagaag      780

ctgcgaccac cccctgccag gactccctgc caacaggaac tggaccaggt cctggagcgg      840

atctccacca tgcgccttcc ggatgagcgg ggccctctgg agcacctcta ctccctgcac      900

atccccaact gtgacaagca tggcctgtac aacctcaaac agtgcaagat gtctctgaac      960

gggcagcgtg gggagtgctg gtgtgtgaac cccaacaccg ggaagctgat ccagggagcc     1020

cccaccatcc ggggggaccc cgagtgtcat ctcttctaca atgagcagca ggaggctcgc     1080

ggggtgcaca cccagcggat gcagtagacc gcagccagcc ggtgcctggc gcccctgccc     1140

cccgcccctc tccaaacacc ggcagaaaac ggagagtgct tgggtggtgg gtgctggagg     1200

attttccagt tctgacacac gtatttatat ttggaaagag accagcaccg agctcggcac     1260

ctccccggcc tctctcttcc cagctgcaga tgccacacct gctccttctt gctttccccg     1320

ggggaggaag ggggttgtgg tcggggagct ggggtacagg tttggggagg gggaagagaa     1380

atttttattt ttgaacccct gtgtcccttt tgcataagat taaaggaagg aaaagtaaa      1439


<210>  68
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  69
<211>  2061
<212>  DNA
<213>  Homo sapiens

<400>  69
gaagcctcac caagcctctg caatgaggtt cttctgtgca cgttgctgca gctttgggcc       60

tgagatgcca gctgtccagc tgctgcttct ggcctgcctg gtgtgggatg tgggggccag      120

gacagctcag ctcaggaagg ccaatgacca gagtggccga tgccagtata ccttcagtgt      180

ggccagtccc aatgaatcca gctgcccaga gcagagccag gccatgtcag tcatccataa      240

cttacagaga gacagcagca cccaacgctt agacctggag gccaccaaag ctcgactcag      300

ctccctggag agcctcctcc accaattgac cttggaccag gctgccaggc cccaggagac      360

ccaggagggg ctgcagaggg agctgggcac cctgaggcgg gagcgggacc agctggaaac      420

ccaaaccaga gagttggaga ctgcctacag caacctcctc cgagacaagt cagttctgga      480

ggaagagaag aagcgactaa ggcaagaaaa tgagaatctg gccaggaggt tggaaagcag      540

cagccaggag gtagcaaggc tgagaagggg ccagtgtccc cagacccgag acactgctcg      600

ggctgtgcca ccaggctcca gagaagtttc tacgtggaat ttggacactt tggccttcca      660

ggaactgaag tccgagctaa ctgaagttcc tgcttcccga attttgaagg agagcccatc      720

tggctatctc aggagtggag agggagacac cggatgtgga gaactagttt gggtaggaga      780

gcctctcacg ctgagaacag cagaaacaat tactggcaag tatggtgtgt ggatgcgaga      840

ccccaagccc acctacccct acacccagga gaccacgtgg agaatcgaca cagttggcac      900

ggatgtccgc caggtttttg agtatgacct catcagccag tttatgcagg gctacccttc      960

taaggttcac atactgccta ggccactgga aagcacgggt gctgtggtgt actcggggag     1020

cctctatttc cagggcgctg agtccagaac tgtcataaga tatgagctga ataccgagac     1080

agtgaaggct gagaaggaaa tccctggagc tggctaccac ggacagttcc cgtattcttg     1140

gggtggctac acggacattg acttggctgt ggatgaagca ggcctctggg tcatttacag     1200

caccgatgag gccaaaggtg ccattgtcct ctccaaactg aacccagaga atctggaact     1260

cgaacaaacc tgggagacaa acatccgtaa gcagtcagtc gccaatgcct tcatcatctg     1320

tggcaccttg tacaccgtca gcagctacac ctcagcagat gctaccgtca actttgctta     1380

tgacacaggc acaggtatca gcaagaccct gaccatccca ttcaagaacc gctataagta     1440

cagcagcatg attgactaca accccctgga gaagaagctc tttgcctggg acaacttgaa     1500

catggtcact tatgacatca agctctccaa gatgtgaaaa gcctccaagc tgtacaggca     1560

atggcagaag gagatgctca gggctcctgg ggggagcagg ctgaagggag agccagccag     1620

ccagggccca ggcagctttg actgctttcc aagttttcat taatccagaa ggatgaacat     1680

ggtcaccatc taactattca ggaattgtag tctgagggcg tagacaattt catataataa     1740

atatccttta tcttctgtca gcatttatgg gatgtttaat gacatagttc aagttttctt     1800

gtgatttggg gcaaaagctg taaggcataa tagtttcttc ctgaaaacca ttgctcttgc     1860

atgttacatg gttaccacaa gccacaataa aaagcataac ttctaaagga agcagaatag     1920

ctcctctggc cagcatcgaa tataagtaag atgcatttac tacagttggc ttctaatgct     1980

tcagatagaa tacagttggg tctcacataa ccctttacat tgtgaaataa aattttctta     2040

cccaaaaaaa aaaaaaaaaa a                                               2061


<210>  70
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Arg Phe Phe Cys Ala Arg Cys Cys Ser Phe Gly Pro Glu Met Pro 
1               5                   10                  15      


Ala Val Gln Leu Leu Leu Leu Ala Cys Leu Val Trp Asp Val Gly Ala 
            20                  25                  30          


Arg Thr Ala Gln Leu Arg Lys Ala Asn Asp Gln Ser Gly Arg Cys Gln 
        35                  40                  45              


Tyr Thr Phe Ser Val Ala Ser Pro Asn Glu Ser Ser Cys Pro Glu Gln 
    50                  55                  60                  


Ser Gln Ala Met Ser Val Ile His Asn Leu Gln Arg Asp Ser Ser Thr 
65                  70                  75                  80  


Gln Arg Leu Asp Leu Glu Ala Thr Lys Ala Arg Leu Ser Ser Leu Glu 
                85                  90                  95      


Ser Leu Leu His Gln Leu Thr Leu Asp Gln Ala Ala Arg Pro Gln Glu 
            100                 105                 110         


Thr Gln Glu Gly Leu Gln Arg Glu Leu Gly Thr Leu Arg Arg Glu Arg 
        115                 120                 125             


Asp Gln Leu Glu Thr Gln Thr Arg Glu Leu Glu Thr Ala Tyr Ser Asn 
    130                 135                 140                 


Leu Leu Arg Asp Lys Ser Val Leu Glu Glu Glu Lys Lys Arg Leu Arg 
145                 150                 155                 160 


Gln Glu Asn Glu Asn Leu Ala Arg Arg Leu Glu Ser Ser Ser Gln Glu 
                165                 170                 175     


Val Ala Arg Leu Arg Arg Gly Gln Cys Pro Gln Thr Arg Asp Thr Ala 
            180                 185                 190         


Arg Ala Val Pro Pro Gly Ser Arg Glu Val Ser Thr Trp Asn Leu Asp 
        195                 200                 205             


Thr Leu Ala Phe Gln Glu Leu Lys Ser Glu Leu Thr Glu Val Pro Ala 
    210                 215                 220                 


Ser Arg Ile Leu Lys Glu Ser Pro Ser Gly Tyr Leu Arg Ser Gly Glu 
225                 230                 235                 240 


Gly Asp Thr Gly Cys Gly Glu Leu Val Trp Val Gly Glu Pro Leu Thr 
                245                 250                 255     


Leu Arg Thr Ala Glu Thr Ile Thr Gly Lys Tyr Gly Val Trp Met Arg 
            260                 265                 270         


Asp Pro Lys Pro Thr Tyr Pro Tyr Thr Gln Glu Thr Thr Trp Arg Ile 
        275                 280                 285             


Asp Thr Val Gly Thr Asp Val Arg Gln Val Phe Glu Tyr Asp Leu Ile 
    290                 295                 300                 


Ser Gln Phe Met Gln Gly Tyr Pro Ser Lys Val His Ile Leu Pro Arg 
305                 310                 315                 320 


Pro Leu Glu Ser Thr Gly Ala Val Val Tyr Ser Gly Ser Leu Tyr Phe 
                325                 330                 335     


Gln Gly Ala Glu Ser Arg Thr Val Ile Arg Tyr Glu Leu Asn Thr Glu 
            340                 345                 350         


Thr Val Lys Ala Glu Lys Glu Ile Pro Gly Ala Gly Tyr His Gly Gln 
        355                 360                 365             


Phe Pro Tyr Ser Trp Gly Gly Tyr Thr Asp Ile Asp Leu Ala Val Asp 
    370                 375                 380                 


Glu Ala Gly Leu Trp Val Ile Tyr 
385                 390         


<210>  71
<211>  1574
<212>  DNA
<213>  Homo sapiens

<400>  71
tcaccacggc ggcagccctt taaacccctc acccagccag cgccccatcc tgtctgtccg       60

aacccagaca caagtcttca ctccttcctg cgagccctga ggaagccttg tgagtgcatt      120

ggctggggct tggagggaag ttgggctgga gctggacagg agcagtgggt gcatttcagg      180

caggctctcc tgaggtccca ggcgccagct ccagctccct ggctagggaa acccaccctc      240

tcagtcagca tgggggccca agctccaggc agggtgggct ggatcactag cgtcctggat      300

ctctctcaga ctgggcagcc ccgggctcat tgaaatgccc cggatgactt ggctagtgca      360

gaggaattga tggaaaccac cggggtgaga gggaggctcc ccatctcagc cagccacatc      420

cacaaggtgt gtgtaagggt gcaggcgccg gccggttagg ccaaggctct actgtctgtt      480

gcccctccag gagaacttcc aaggagcttt ccccagacat ggccaacaag ggtccttcct      540

atggcatgag ccgcgaagtg cagtccaaaa tcgagaagaa gtatgacgag gagctggagg      600

agcggctggt ggagtggatc atagtgcagt gtggccctga tgtgggccgc ccagaccgtg      660

ggcgcttggg cttccaggtc tggctgaaga atggcgtgat tctgagcaag ctggtgaaca      720

gcctgtaccc tgatggctcc aagccggtga aggtgcccga gaacccaccc tccatggtct      780

tcaagcagat ggagcaggtg gctcagttcc tgaaggcggc tgaggactat ggggtcatca      840

agactgacat gttccagact gttgacctct ttgaaggcaa agacatggca gcagtgcaga      900

ggaccctgat ggctttgggc agcttggcag tgaccaagaa tgatgggcac taccgtggag      960

atcccaactg gtttatgaag aaagcgcagg agcataagag ggaattcaca gagagccagc     1020

tgcaggaggg aaagcatgtc attggccttc agatgggcag caacagaggg gcctcccagg     1080

ccggcatgac aggctacgga cgacctcggc agatcatcag ttagagcgga gagggctagc     1140

cctgagcccg gccctccccc agctccttgg ctgcagccat cccgcttagc ctgcctcacc     1200

cacacccgtg tggtaccttc agccctggcc aagctttgag gctctgtcac tgagcaatgg     1260

taactgcacc tgggcagctc ctccctgtgc ccccagcctc agcccaactt cttacccgaa     1320

agcatcactg ccttggcccc tccctcccgg ctgcccccat cacctctact gtctcctccc     1380

tgggctaagc aggggagaag cgggctgggg gtagcctgga tgtgggccaa gtccactgtc     1440

ctccttggcg gcaaaagccc attgaagaag aaccagccca gcctgccccc tatcttgtcc     1500

tggaatattt ttggggttgg aactcaaaaa aaaaaaaaaa aaatcaatct tttctcaaaa     1560

aaaaaaaaaa aaaa                                                       1574


<210>  72
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Asn Lys Gly Pro Ser Tyr Gly Met Ser Arg Glu Val Gln Ser 
1               5                   10                  15      


Lys Ile Glu Lys Lys Tyr Asp Glu Glu Leu Glu Glu Arg Leu Val Glu 
            20                  25                  30          


Trp Ile Ile Val Gln Cys Gly Pro Asp Val Gly Arg Pro Asp Arg Gly 
        35                  40                  45              


Arg Leu Gly Phe Gln Val Trp Leu Lys Asn Gly Val Ile Leu Ser Lys 
    50                  55                  60                  


Leu Val Asn Ser Leu Tyr Pro Asp Gly Ser Lys Pro Val Lys Val Pro 
65                  70                  75                  80  


Glu Asn Pro Pro Ser Met Val Phe Lys Gln Met Glu Gln Val Ala Gln 
                85                  90                  95      


Phe Leu Lys Ala Ala Glu Asp Tyr Gly Val Ile Lys Thr Asp Met Phe 
            100                 105                 110         


Gln Thr Val Asp Leu Phe Glu Gly Lys Asp Met Ala Ala Val Gln Arg 
        115                 120                 125             


Thr Leu Met Ala Leu Gly Ser Leu Ala Val Thr Lys Asn Asp Gly His 
    130                 135                 140                 


Tyr Arg Gly Asp Pro Asn Trp Phe Met Lys Lys Ala Gln Glu His Lys 
145                 150                 155                 160 


Arg Glu Phe Thr Glu Ser Gln Leu Gln Glu Gly Lys His Val Ile Gly 
                165                 170                 175     


Leu Gln Met Gly Ser Asn Arg Gly Ala Ser Gln Ala Gly Met Thr Gly 
            180                 185                 190         


Tyr Gly Arg Pro Arg Gln Ile Ile Ser 
        195                 200     


<210>  73
<211>  4048
<212>  DNA
<213>  Homo sapiens

<400>  73
ggctgcctcg caggggctgc gcgcagcggc aagaagtgtc tgggctggga cggacaggag       60

aggctgtcgc catcggcgtc ctgtgcccct ctgctccggc acggccctgt cgcagtgccc      120

gcgctttccc cggcgcctgc acgcggcgcg cctgggtaac atgcttgggg tcctggtcct      180

tggcgcgctg gccctggccg gcctggggtt ccccgcaccc gcagagccgc agccgggtgg      240

cagccagtgc gtcgagcacg actgcttcgc gctctacccg ggccccgcga ccttcctcaa      300

tgccagtcag atctgcgacg gactgcgggg ccacctaatg acagtgcgct cctcggtggc      360

tgccgatgtc atttccttgc tactgaacgg cgacggcggc gttggccgcc ggcgcctctg      420

gatcggcctg cagctgccac ccggctgcgg cgaccccaag cgcctcgggc ccctgcgcgg      480

cttccagtgg gttacgggag acaacaacac cagctatagc aggtgggcac ggctcgacct      540

caatggggct cccctctgcg gcccgttgtg cgtcgctgtc tccgctgctg aggccactgt      600

gcccagcgag ccgatctggg aggagcagca gtgcgaagtg aaggccgatg gcttcctctg      660

cgagttccac ttcccagcca cctgcaggcc actggctgtg gagcccggcg ccgcggctgc      720

cgccgtctcg atcacctacg gcaccccgtt cgcggcccgc ggagcggact tccaggcgct      780

gccggtgggc agctccgccg cggtggctcc cctcggctta cagctaatgt gcaccgcgcc      840

gcccggagcg gtccaggggc actgggccag ggaggcgccg ggcgcttggg actgcagcgt      900

ggagaacggc ggctgcgagc acgcgtgcaa tgcgatccct ggggctcccc gctgccagtg      960

cccagccggc gccgccctgc aggcagacgg gcgctcctgc accgcatccg cgacgcagtc     1020

ctgcaacgac ctctgcgagc acttctgcgt tcccaacccc gaccagccgg gctcctactc     1080

gtgcatgtgc gagaccggct accggctggc ggccgaccaa caccggtgcg aggacgtgga     1140

tgactgcata ctggagccca gtccgtgtcc gcagcgctgt gtcaacacac agggtggctt     1200

cgagtgccac tgctacccta actacgacct ggtggacggc gagtgtgtgg agcccgtgga     1260

cccgtgcttc agagccaact gcgagtacca gtgccagccc ctgaaccaaa ctagctacct     1320

ctgcgtctgc gccgagggct tcgcgcccat tccccacgag ccgcacaggt gccagatgtt     1380

ttgcaaccag actgcctgtc cagccgactg cgaccccaac acccaggcta gctgtgagtg     1440

ccctgaaggc tacatcctgg acgacggttt catctgcacg gacatcgacg agtgcgaaaa     1500

cggcggcttc tgctccgggg tgtgccacaa cctccccggt accttcgagt gcatctgcgg     1560

gcccgactcg gcccttgccc gccacattgg caccgactgt gactccggca aggtggacgg     1620

tggcgacagc ggctctggcg agcccccgcc cagcccgacg cccggctcca ccttgactcc     1680

tccggccgtg gggctcgtgc attcgggctt gctcataggc atctccatcg cgagcctgtg     1740

cctggtggtg gcgcttttgg cgctcctctg ccacctgcgc aagaagcagg gcgccgccag     1800

ggccaagatg gagtacaagt gcgcggcccc ttccaaggag gtagtgctgc agcacgtgcg     1860

gaccgagcgg acgccgcaga gactctgagc ggcctccgtc caggagcctg gctccgtcca     1920

ggagcctgtg cctcctcacc cccagctttg ctaccaaagc accttagctg gcattacagc     1980

tggagaagac cctccccgca ccccccaagc tgttttcttc tattccatgg ctaactggcg     2040

agggggtgat tagagggagg agaatgagcc tcggcctctt ccgtgacgtc actggaccac     2100

tgggcaatga tggcaatttt gtaacgaaga cacagactgc gatttgtccc aggtcctcac     2160

taccgggcgc aggagggtga gcgttattgg tcggcagcct tctgggcaga ccttgacctc     2220

gtgggctagg gatgactaaa atatttattt tttttaagta tttaggtttt tgtttgtttc     2280

ctttgttctt acctgtatgt ctccagtatc cactttgcac agctctccgg tctctctctc     2340

tctacaaact cccacttgtc atgtgacagg taaactatct tggtgaattt ttttttccta     2400

gccctctcac atttatgaag caagccccac ttattcccca ttcttcctag ttttctcctc     2460

ccaggaactg ggccaactca cctgagtcac cctacctgtg cctgacccta cttcttttgc     2520

tcttagctgt ctgctcagac agaaccccta catgaaacag aaacaaaaac actaaaaata     2580

aaaatggcca tttgcttttt caccagattt gctaatttat cctgaaattt cagattccca     2640

gagcaaaata attttaaaca aaggttgaga tgtaaaaggt attaaattga tgttgctgga     2700

ctgtcataga aattacaccc aaagaggtat ttatctttac ttttaaacag tgagcctgaa     2760

ttttgttgct gttttgattt gtactgaaaa atggtaattg ttgctaatct tcttatgcaa     2820

tttccttttt tgttattatt acttattttt gacagtgttg aaaatgttca gaaggttgct     2880

ctagattgag agaagagaca aacacctccc aggagacagt tcaagaaagc ttcaaactgc     2940

atgattcatg ccaattagca attgactgtc actgttcctt gtcactggta gaccaaaata     3000

aaaccagctc tactggtctt gtggaattgg gagcttggga atggatcctg gaggatgccc     3060

aattagggcc tagccttaat caggtcctca gagaatttct accatttcag agaggccttt     3120

tggaatgtgg cccctgaaca agaattggaa gctgccctgc ccatgggagc tggttagaaa     3180

tgcagaatcc taggctccac cccatccagt tcatgagaat ctatatttaa caagatctgc     3240

agggggtgtg tctgctcagt aatttgagga caaccattcc agactgcttc caattttctg     3300

gaatacatga aatatagatc agttataagt agcaggccaa gtcaggccct tattttcaag     3360

aaactgagga attttctttg tgtagctttg ctctttggta gaaaaggcta ggtacacagc     3420

tctagacact gccacacagg gtctgcaagg tctttggttc agctaagcta ggaatgaaat     3480

cctgcttcag tgtatggaaa taaatgtatc atagaaatgt aacttttgta agacaaaggt     3540

tttcctcttc tattttgtaa actcaaaata tttgtacata gttatttatt tattggagat     3600

aatctagaac acaggcaaaa tccttgctta tgacatcact tgtacaaaat aaacaaataa     3660

caatgtgctc tcgggttgtg tgtctgttca cttttcctcc ctcagtgccc tcattttatg     3720

tcattaaatg gggctcacaa accatgcaaa tgctatgaga tgcatggagg gctgccctgt     3780

accccagcac ttgtgttgtc tggtggtggc accatctctg attttcaaag ctttttccag     3840

aggctattat tttcactgta gaatgatttc atgctatctc tgtgtgcaca aatatttatt     3900

ttctttctgt aaccataaca acttcatata tgaggacttg tgtctctgtg cttttaaatg     3960

cataaatgca ttataggatc atttgttgga atgaattaaa taaacccttc ctggggcatc     4020

tggcgaatcc caaaaaaaaa aaaaaaaa                                        4048


<210>  74
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
        35                  40                  45              


Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
65                  70                  75                  80  


Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                85                  90                  95      


Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
            100                 105                 110         


Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
        115                 120                 125             


Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
    130                 135                 140                 


Ala Thr Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val 
145                 150                 155                 160 


Lys Ala Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg 
                165                 170                 175     


Pro Leu Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr 
            180                 185                 190         


Tyr Gly Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro 
        195                 200                 205             


Val Gly Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys 
    210                 215                 220                 


Thr Ala Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro 
225                 230                 235                 240 


Gly Ala Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys 
                245                 250                 255     


Asn Ala Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala 
            260                 265                 270         


Leu Gln Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys 
        275                 280                 285             


Asn Asp Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly 
    290                 295                 300                 


Ser Tyr Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln 
305                 310                 315                 320 


His Arg Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys 
                325                 330                 335     


Pro Gln Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr 
            340                 345                 350         


Pro Asn Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro 
        355                 360                 365             


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
    370                 375                 380                 


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
385                 390                 395                 400 


Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
                405                 410                 415     


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
            420                 425                 430         


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
        435                 440                 445             


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
    450                 455                 460                 


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
465                 470                 475                 480 


Asp Ser Gly Lys Val Asp Gly Gly Asp Ser Gly Ser Gly Glu Pro Pro 
                485                 490                 495     


Pro Ser Pro Thr Pro Gly Ser Thr Leu Thr Pro Pro Ala Val Gly Leu 
            500                 505                 510         


Val His Ser Gly Leu Leu Ile Gly Ile Ser Ile Ala Ser Leu Cys Leu 
        515                 520                 525             


Val Val Ala Leu Leu Ala Leu Leu Cys His Leu Arg Lys Lys Gln Gly 
    530                 535                 540                 


Ala Ala Arg Ala Lys Met Glu Tyr Lys Cys Ala Ala Pro Ser Lys Glu 
545                 550                 555                 560 


Val Val Leu Gln His Val Arg Thr Glu Arg Thr Pro Gln Arg Leu 
                565                 570                 575 


<210>  75
<211>  5826
<212>  DNA
<213>  Homo sapiens

<400>  75
gaggaggaga cggcatccag tacagagggg ctggacttgg acccctgcag cagccctgca       60

caggagaagc ggcatataaa gccgcgctgc ccgggagccg ctcggccacg tccaccggag      120

catcctgcac tgcagggccg gtctctcgct ccagcagagc ctgcgccttt ctgactcggt      180

ccggaacact gaaaccagtc atcactgcat ctttttggca aaccaggagc tcagctgcag      240

gaggcaggat ggtctggagg ctggtcctgc tggctctgtg ggtgtggccc agcacgcaag      300

ctggtcacca ggacaaagac acgaccttcg accttttcag tatcagcaac atcaaccgca      360

agaccattgg cgccaagcag ttccgcgggc ccgaccccgg cgtgccggct taccgcttcg      420

tgcgctttga ctacatccca ccggtgaacg cagatgacct cagcaagatc accaagatca      480

tgcggcagaa ggagggcttc ttcctcacgg cccagctcaa gcaggacggc aagtccaggg      540

gcacgctgtt ggctctggag ggccccggtc tctcccagag gcagttcgag atcgtctcca      600

acggccccgc ggacacgctg gatctcacct actggattga cggcacccgg catgtggtct      660

ccctggagga cgtcggcctg gctgactcgc agtggaagaa cgtcaccgtg caggtggctg      720

gcgagaccta cagcttgcac gtgggctgcg acctcataga cagcttcgct ctggacgagc      780

ccttctacga gcacctgcag gcggaaaaga gccggatgta cgtggccaaa ggctctgcca      840

gagagagtca cttcaggggt ttgcttcaga acgtccacct agtgtttgaa aactctgtgg      900

aagatattct aagcaagaag ggttgccagc aaggccaggg agctgagatc aacgccatca      960

gtgagaacac agagacgctg cgcctgggtc cgcatgtcac caccgagtac gtgggcccca     1020

gctcggagag gaggcccgag gtgtgcgaac gctcgtgcga ggagctggga aacatggtcc     1080

aggagctctc ggggctccac gtcctcgtga accagctcag cgagaacctc aagagagtgt     1140

cgaatgataa ccagtttctc tgggagctca ttggtggccc tcctaagaca aggaacatgt     1200

cagcttgctg gcaggatggc cggttctttg cggaaaatga aacgtgggtg gtggacagct     1260

gcaccacgtg tacctgcaag aaatttaaaa ccatttgcca ccaaatcacc tgcccgcctg     1320

caacctgcgc cagtccatcc tttgtggaag gcgaatgctg cccttcctgc ctccactcgg     1380

tggacggtga ggagggctgg tctccgtggg cagagtggac ccagtgctcc gtgacgtgtg     1440

gctctgggac ccagcagaga ggccggtcct gtgacgtcac cagcaacacc tgcttggggc     1500

cctccatcca gacacgggct tgcagtctga gcaagtgtga cacccgcatc cggcaggacg     1560

gcggctggag ccactggtca ccttggtctt catgctctgt gacctgtgga gttggcaata     1620

tcacacgcat ccgtctctgc aactccccag tgccccagat ggggggcaag aattgcaaag     1680

ggagtggccg ggagaccaaa gcctgccagg gcgccccatg cccaatcgat ggccgctgga     1740

gcccctggtc cccgtggtcg gcctgcactg tcacctgtgc cggtgggatc cgggagcgca     1800

cccgggtctg caacagccct gagcctcagt acggagggaa ggcctgcgtg ggggatgtgc     1860

aggagcgtca gatgtgcaac aagaggagct gccccgtgga tggctgttta tccaacccct     1920

gcttcccggg agcccagtgc agcagcttcc ccgatgggtc ctggtcatgc ggctcctgcc     1980

ctgtgggctt cttgggcaat ggcacccact gtgaggacct ggacgagtgt gccctggtcc     2040

ccgacatctg cttctccacc agcaaggtgc ctcgctgtgt caacactcag cctggcttcc     2100

actgcctgcc ctgcccgccc cgatacagag ggaaccagcc cgtcggggtc ggcctggaag     2160

cagccaagac ggaaaagcaa gtgtgtgagc ccgaaaaccc atgcaaggac aagacacaca     2220

actgccacaa gcacgcggag tgcatctacc tgggccactt cagcgacccc atgtacaagt     2280

gcgagtgcca gacaggctac gcgggcgacg ggctcatctg cggggaggac tcggacctgg     2340

acggctggcc caacctcaat ctggtctgcg ccaccaacgc cacctaccac tgcatcaagg     2400

ataactgccc ccatctgcca aattctgggc aggaagactt tgacaaggac gggattggcg     2460

atgcctgtga tgatgacgat gacaatgacg gtgtgaccga tgagaaggac aactgccagc     2520

tcctcttcaa tccccgccag gctgactatg acaaggatga ggttggggac cgctgtgaca     2580

actgccctta cgtgcacaac cctgcccaga tcgacacaga caacaatgga gagggtgacg     2640

cctgctccgt ggacattgat ggggacgatg tcttcaatga acgagacaat tgtccctacg     2700

tctacaacac tgaccagagg gacacggatg gtgacggtgt gggggatcac tgtgacaact     2760

gccccctggt gcacaaccct gaccagaccg acgtggacaa tgaccttgtt ggggaccagt     2820

gtgacaacaa cgaggacata gatgacgacg gccaccagaa caaccaggac aactgcccct     2880

acatctccaa cgccaaccag gctgaccatg acagagacgg ccagggcgac gcctgtgacc     2940

ctgatgatga caacgatggc gtccccgatg acagggacaa ctgccggctt gtgttcaacc     3000

cagaccagga ggacttggac ggtgatggac ggggtgatat ttgtaaagat gattttgaca     3060

atgacaacat cccagatatt gatgatgtgt gtcctgaaaa caatgccatc agtgagacag     3120

acttcaggaa cttccagatg gtccccttgg atcccaaagg gaccacccaa attgatccca     3180

actgggtcat tcgccatcaa ggcaaggagc tggttcagac agccaactcg gaccccggca     3240

tcgctgtagg ttttgacgag tttgggtctg tggacttcag tggcacattc tacgtaaaca     3300

ctgaccggga cgacgactat gccggcttcg tctttggtta ccagtcaagc agccgcttct     3360

atgtggtgat gtggaagcag gtgacgcaga cctactggga ggaccagccc acgcgggcct     3420

atggctactc cggcgtgtcc ctcaaggtgg tgaactccac cacggggacg ggcgagcacc     3480

tgaggaacgc gctgtggcac acggggaaca cgccggggca ggtgcgaacc ttatggcacg     3540

accccaggaa cattggctgg aaggactaca cggcctatag gtggcacctg actcacaggc     3600

ccaagactgg ctacatcaga gtcttagtgc atgaaggaaa acaggtcatg gcagactcag     3660

gacctatcta tgaccaaacc tacgctggcg ggcggctggg tctatttgtc ttctctcaag     3720

aaatggtcta tttctcagac ctcaagtacg aatgcagaga tatttaaaca agatttgctg     3780

catttccggc aatgccctgt gcatgccatg gtccctagac acctcagttc attgtggtcc     3840

ttgtggcttc tctctctagc agcacctcct gtcccttgac cttaactctg atggttcttc     3900

acctcctgcc agcaacccca aacccaagtg ccttcagagg ataaatatca atggaactca     3960

gagatgaaca tctaacccac tagaggaaac cagtttggtg atatatgaga ctttatgtgg     4020

agtgaaaatt gggcatgcca ttacattgct ttttcttgtt tgtttaaaaa gaatgacgtt     4080

tacatataaa atgtaattac ttattgtatt tatgtgtata tggagttgaa gggaatactg     4140

tgcataagcc attatgataa attaagcatg aaaaatattg ctgaactact tttggtgctt     4200

aaagttgtca ctattcttga attagagttg ctctacaatg acacacaaat cccattaaat     4260

aaattataaa caagggtcaa ttcaaatttg aagtaatgtt ttagtaagga gagattagaa     4320

gacaacaggc atagcaaatg acataagcta ccgattaact aatcggaaca tgtaaaacag     4380

ttacaaaaat aaacgaactc tcctcttgtc ctacaatgaa agccctcatg tgcagtagag     4440

atgcagtttc atcaaagaac aaacatcctt gcaaatgggt gtgacgcggt tccagatgtg     4500

gatttggcaa aacctcattt aagtaaaagg ttagcagagc aaagtgcggt gctttagctg     4560

ctgcttgtgc cgctgtggcg tcggggaggc tcctgcctga gcttccttcc ccagctttgc     4620

tgcctgagag gaaccagagc agacgcacag gccggaaaag gcgcatctaa cgcgtatcta     4680

ggctttggta actgcggaca agttgctttt acctgatttg atgatacatt tcattaaggt     4740

tccagttata aatattttgt taatatttat taagtgacta tagaatgcaa ctccatttac     4800

cagtaactta ttttaaatat gcctagtaac acatatgtag tataatttct agaaacaaac     4860

atctaataag tatataatcc tgtgaaaata tgaggcttga taatattagg ttgtcacgat     4920

gaagcatgct agaagctgta acagaataca tagagaataa tgaggagttt atgatggaac     4980

cttaaatata taatgttgcc agcgatttta gttcaatatt tgttactgtt atctatctgc     5040

tgtatatgga attcttttaa ttcaaacgct gaaaagaatc agcatttagt cttgccaggc     5100

acacccaata atcagtcatg tgtaatatgc acaagtttgt ttttgttttt gttttttttg     5160

ttggttggtt tgtttttttg ctttaagttg catgatcttt ctgcaggaaa tagtcactca     5220

tcccactcca cataaggggt ttagtaagag aagtctgtct gtctgatgat ggataggggg     5280

caaatctttt tcccctttct gttaatagtc atcacatttc tatgccaaac aggaacaatc     5340

cataacttta gtcttaatgt acacattgca ttttgataaa attaattttg ttgtttcctt     5400

tgaggttgat cgttgtgttg ttgttttgct gcacttttta cttttttgcg tgtggagctg     5460

tattcccgag accaacgaag cgttgggata cttcattaaa tgtagcgact gtcaacagcg     5520

tgcaggtttt ctgtttctgt gttgtggggt caaccgtaca atggtgtggg agtgacgatg     5580

atgtgaatat ttagaatgta ccatattttt tgtaaattat ttatgttttt ctaaacaaat     5640

ttatcgtata ggttgatgaa acgtcatgtg ttttgccaaa gactgtaaat atttatttat     5700

gtgttcacat ggtcaaaatt tcaccactga aaccctgcac ttagctagaa cctcattttt     5760

aaagattaac aacaggaaat aaattgtaaa aaaggttttc tatacatgaa aaaaaaaaaa     5820

aaaaaa                                                                5826


<210>  76
<211>  1172
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Val Trp Arg Leu Val Leu Leu Ala Leu Trp Val Trp Pro Ser Thr 
1               5                   10                  15      


Gln Ala Gly His Gln Asp Lys Asp Thr Thr Phe Asp Leu Phe Ser Ile 
            20                  25                  30          


Ser Asn Ile Asn Arg Lys Thr Ile Gly Ala Lys Gln Phe Arg Gly Pro 
        35                  40                  45              


Asp Pro Gly Val Pro Ala Tyr Arg Phe Val Arg Phe Asp Tyr Ile Pro 
    50                  55                  60                  


Pro Val Asn Ala Asp Asp Leu Ser Lys Ile Thr Lys Ile Met Arg Gln 
65                  70                  75                  80  


Lys Glu Gly Phe Phe Leu Thr Ala Gln Leu Lys Gln Asp Gly Lys Ser 
                85                  90                  95      


Arg Gly Thr Leu Leu Ala Leu Glu Gly Pro Gly Leu Ser Gln Arg Gln 
            100                 105                 110         


Phe Glu Ile Val Ser Asn Gly Pro Ala Asp Thr Leu Asp Leu Thr Tyr 
        115                 120                 125             


Trp Ile Asp Gly Thr Arg His Val Val Ser Leu Glu Asp Val Gly Leu 
    130                 135                 140                 


Ala Asp Ser Gln Trp Lys Asn Val Thr Val Gln Val Ala Gly Glu Thr 
145                 150                 155                 160 


Tyr Ser Leu His Val Gly Cys Asp Leu Ile Asp Ser Phe Ala Leu Asp 
                165                 170                 175     


Glu Pro Phe Tyr Glu His Leu Gln Ala Glu Lys Ser Arg Met Tyr Val 
            180                 185                 190         


Ala Lys Gly Ser Ala Arg Glu Ser His Phe Arg Gly Leu Leu Gln Asn 
        195                 200                 205             


Val His Leu Val Phe Glu Asn Ser Val Glu Asp Ile Leu Ser Lys Lys 
    210                 215                 220                 


Gly Cys Gln Gln Gly Gln Gly Ala Glu Ile Asn Ala Ile Ser Glu Asn 
225                 230                 235                 240 


Thr Glu Thr Leu Arg Leu Gly Pro His Val Thr Thr Glu Tyr Val Gly 
                245                 250                 255     


Pro Ser Ser Glu Arg Arg Pro Glu Val Cys Glu Arg Ser Cys Glu Glu 
            260                 265                 270         


Leu Gly Asn Met Val Gln Glu Leu Ser Gly Leu His Val Leu Val Asn 
        275                 280                 285             


Gln Leu Ser Glu Asn Leu Lys Arg Val Ser Asn Asp Asn Gln Phe Leu 
    290                 295                 300                 


Trp Glu Leu Ile Gly Gly Pro Pro Lys Thr Arg Asn Met Ser Ala Cys 
305                 310                 315                 320 


Trp Gln Asp Gly Arg Phe Phe Ala Glu Asn Glu Thr Trp Val Val Asp 
                325                 330                 335     


Ser Cys Thr Thr Cys Thr Cys Lys Lys Phe Lys Thr Ile Cys His Gln 
            340                 345                 350         


Ile Thr Cys Pro Pro Ala Thr Cys Ala Ser Pro Ser Phe Val Glu Gly 
        355                 360                 365             


Glu Cys Cys Pro Ser Cys Leu His Ser Val Asp Gly Glu Glu Gly Trp 
    370                 375                 380                 


Ser Pro Trp Ala Glu Trp Thr Gln Cys Ser Val Thr Cys Gly Ser Gly 
385                 390                 395                 400 


Thr Gln Gln Arg Gly Arg Ser Cys Asp Val Thr Ser Asn Thr Cys Leu 
                405                 410                 415     


Gly Pro Ser Ile Gln Thr Arg Ala Cys Ser Leu Ser Lys Cys Asp Thr 
            420                 425                 430         


Arg Ile Arg Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser 
        435                 440                 445             


Cys Ser Val Thr Cys Gly Val Gly Asn Ile Thr Arg Ile Arg Leu Cys 
    450                 455                 460                 


Asn Ser Pro Val Pro Gln Met Gly Gly Lys Asn Cys Lys Gly Ser Gly 
465                 470                 475                 480 


Arg Glu Thr Lys Ala Cys Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg 
                485                 490                 495     


Trp Ser Pro Trp Ser Pro Trp Ser Ala Cys Thr Val Thr Cys Ala Gly 
            500                 505                 510         


Gly Ile Arg Glu Arg Thr Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr 
        515                 520                 525             


Gly Gly Lys Ala Cys Val Gly Asp Val Gln Glu Arg Gln Met Cys Asn 
    530                 535                 540                 


Lys Arg Ser Cys Pro Val Asp Gly Cys Leu Ser Asn Pro Cys Phe Pro 
545                 550                 555                 560 


Gly Ala Gln Cys Ser Ser Phe Pro Asp Gly Ser Trp Ser Cys Gly Ser 
                565                 570                 575     


Cys Pro Val Gly Phe Leu Gly Asn Gly Thr His Cys Glu Asp Leu Asp 
            580                 585                 590         


Glu Cys Ala Leu Val Pro Asp Ile Cys Phe Ser Thr Ser Lys Val Pro 
        595                 600                 605             


Arg Cys Val Asn Thr Gln Pro Gly Phe His Cys Leu Pro Cys Pro Pro 
    610                 615                 620                 


Arg Tyr Arg Gly Asn Gln Pro Val Gly Val Gly Leu Glu Ala Ala Lys 
625                 630                 635                 640 


Thr Glu Lys Gln Val Cys Glu Pro Glu Asn Pro Cys Lys Asp Lys Thr 
                645                 650                 655     


His Asn Cys His Lys His Ala Glu Cys Ile Tyr Leu Gly His Phe Ser 
            660                 665                 670         


Asp Pro Met Tyr Lys Cys Glu Cys Gln Thr Gly Tyr Ala Gly Asp Gly 
        675                 680                 685             


Leu Ile Cys Gly Glu Asp Ser Asp Leu Asp Gly Trp Pro Asn Leu Asn 
    690                 695                 700                 


Leu Val Cys Ala Thr Asn Ala Thr Tyr His Cys Ile Lys Asp Asn Cys 
705                 710                 715                 720 


Pro His Leu Pro Asn Ser Gly Gln Glu Asp Phe Asp Lys Asp Gly Ile 
                725                 730                 735     


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Thr Asp Glu 
            740                 745                 750         


Lys Asp Asn Cys Gln Leu Leu Phe Asn Pro Arg Gln Ala Asp Tyr Asp 
        755                 760                 765             


Lys Asp Glu Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Val His Asn 
    770                 775                 780                 


Pro Ala Gln Ile Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ser 
785                 790                 795                 800 


Val Asp Ile Asp Gly Asp Asp Val Phe Asn Glu Arg Asp Asn Cys Pro 
                805                 810                 815     


Tyr Val Tyr Asn Thr Asp Gln Arg Asp Thr Asp Gly Asp Gly Val Gly 
            820                 825                 830         


Asp His Cys Asp Asn Cys Pro Leu Val His Asn Pro Asp Gln Thr Asp 
        835                 840                 845             


Val Asp Asn Asp Leu Val Gly Asp Gln Cys Asp Asn Asn Glu Asp Ile 
    850                 855                 860                 


Asp Asp Asp Gly His Gln Asn Asn Gln Asp Asn Cys Pro Tyr Ile Ser 
865                 870                 875                 880 


Asn Ala Asn Gln Ala Asp His Asp Arg Asp Gly Gln Gly Asp Ala Cys 
                885                 890                 895     


Asp Pro Asp Asp Asp Asn Asp Gly Val Pro Asp Asp Arg Asp Asn Cys 
            900                 905                 910         


Arg Leu Val Phe Asn Pro Asp Gln Glu Asp Leu Asp Gly Asp Gly Arg 
        915                 920                 925             


Gly Asp Ile Cys Lys Asp Asp Phe Asp Asn Asp Asn Ile Pro Asp Ile 
    930                 935                 940                 


Asp Asp Val Cys Pro Glu Asn Asn Ala Ile Ser Glu Thr Asp Phe Arg 
945                 950                 955                 960 


Asn Phe Gln Met Val Pro Leu Asp Pro Lys Gly Thr Thr Gln Ile Asp 
                965                 970                 975     


Pro Asn Trp Val Ile Arg His Gln Gly Lys Glu Leu Val Gln Thr Ala 
            980                 985                 990         


Asn Ser Asp Pro Gly Ile Ala Val  Gly Phe Asp Glu Phe  Gly Ser Val 
        995                 1000                 1005             


Asp Phe  Ser Gly Thr Phe Tyr  Val Asn Thr Asp Arg  Asp Asp Asp 
    1010                 1015                 1020             


Tyr Ala  Gly Phe Val Phe Gly  Tyr Gln Ser Ser Ser  Arg Phe Tyr 
    1025                 1030                 1035             


Val Val  Met Trp Lys Gln Val  Thr Gln Thr Tyr Trp  Glu Asp Gln 
    1040                 1045                 1050             


Pro Thr  Arg Ala Tyr Gly Tyr  Ser Gly Val Ser Leu  Lys Val Val 
    1055                 1060                 1065             


Asn Ser  Thr Thr Gly Thr Gly  Glu His Leu Arg Asn  Ala Leu Trp 
    1070                 1075                 1080             


His Thr  Gly Asn Thr Pro Gly  Gln Val Arg Thr Leu  Trp His Asp 
    1085                 1090                 1095             


Pro Arg  Asn Ile Gly Trp Lys  Asp Tyr Thr Ala Tyr  Arg Trp His 
    1100                 1105                 1110             


Leu Thr  His Arg Pro Lys Thr  Gly Tyr Ile Arg Val  Leu Val His 
    1115                 1120                 1125             


Glu Gly  Lys Gln Val Met Ala  Asp Ser Gly Pro Ile  Tyr Asp Gln 
    1130                 1135                 1140             


Thr Tyr  Ala Gly Gly Arg Leu  Gly Leu Phe Val Phe  Ser Gln Glu 
    1145                 1150                 1155             


Met Val  Tyr Phe Ser Asp Leu  Lys Tyr Glu Cys Arg  Asp Ile 
    1160                 1165                 1170         


<210>  77
<211>  1148
<212>  DNA
<213>  Homo sapiens

<400>  77
tctctctcgc acacataccc acacacacac acacacacac acacgcgcgc gcgaaaacaa       60

tatctcattt cttcttcagg gagcagctgt gaaggaaatc gggggaggag gatggacaca      120

acatcccatc tttgtgtttc gatacagact aagcttttag gccaaccctc ctgactggat      180

gggggcggcg ggcgtggcat gcatgaaaag taaacatcag agacctgaag aagcttataa      240

aatagcttgg gagaggccag tcaccaagac aggcatctca aatcggctga ttctgcatct      300

ggaaactgcc ttcatcttga aagaaaagct ccaggtccct tctccagcca cccagcccca      360

agatggtgat gctgctgctg ctgctttccg cactggctgg cctcttcggt gcggcagagg      420

gacaagcatt tcatcttggg aagtgcccca atcctccggt gcaggagaat tttgacgtga      480

ataagtatct cggaagatgg tacgaaattg agaagatccc aacaaccttt gagaatggac      540

gctgcatcca ggccaactac tcactaatgg aaaacggaaa gatcaaagtg ttaaaccagg      600

agttgagagc tgatggaact gtgaatcaaa tcgaaggtga agccacccca gttaacctca      660

cagagcctgc caagctggaa gttaagtttt cctggtttat gccatcggca ccgtactgga      720

tcctggccac cgactatgag aactatgccc tcgtgtattc ctgtacctgc atcatccaac      780

tttttcacgt ggattttgct tggatcttgg caagaaaccc taatctccct ccagaaacag      840

tggactctct aaaaaatatc ctgacttcta ataacattga tgtcaagaaa atgacggtca      900

cagaccaggt gaactgcccc aagctctcgt aaccaggttc tacagggagg ctgcacccac      960

tccatgttac ttctgcttcg ctttccccta cccccccccc ataaagacaa accaatcaac     1020

cacgacaaag gaagttgacc tgaacatgta accatgccct accctgttac cttgctagct     1080

gcaaaataaa cttgttgctg acctgctgtg ctcgcagtag attccaagtt aaaaaaaaaa     1140

aaaaaaaa                                                              1148


<210>  78
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly 
1               5                   10                  15      


Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro 
            20                  25                  30          


Val Gln Glu Asn Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu 
        35                  40                  45              


Ile Glu Lys Ile Pro Thr Thr Phe Glu Asn Gly Arg Cys Ile Gln Ala 
    50                  55                  60                  


Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu 
65                  70                  75                  80  


Leu Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly Glu Ala Thr Pro 
                85                  90                  95      


Val Asn Leu Thr Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe 
            100                 105                 110         


Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Thr Asp Tyr Glu Asn Tyr 
        115                 120                 125             


Ala Leu Val Tyr Ser Cys Thr Cys Ile Ile Gln Leu Phe His Val Asp 
    130                 135                 140                 


Phe Ala Trp Ile Leu Ala Arg Asn Pro Asn Leu Pro Pro Glu Thr Val 
145                 150                 155                 160 


Asp Ser Leu Lys Asn Ile Leu Thr Ser Asn Asn Ile Asp Val Lys Lys 
                165                 170                 175     


Met Thr Val Thr Asp Gln Val Asn Cys Pro Lys Leu Ser 
            180                 185                 


<210>  79
<211>  1629
<212>  DNA
<213>  Homo sapiens

<400>  79
attcatgaaa atccactact ccagacagac ggctttggaa tccaccagct acatccagct       60

ccctgaggca gagttgagaa tggagagaat gttacctctc ctggctctgg ggctcttggc      120

ggctgggttc tgccctgctg tcctctgcca ccctaacagc ccacttgacg aggagaatct      180

gacccaggag aaccaagacc gagggacaca cgtggacctc ggattagcct ccgccaacgt      240

ggacttcgct ttcagcctgt acaagcagtt agtcctgaag gcccctgata agaatgtcat      300

cttctcccca ctgagcatct ccaccgcctt ggccttcctg tctctggggg cccataatac      360

caccctgaca gagattctca aaggcctcaa gttcaacctc acggagactt ctgaggcaga      420

aattcaccag agcttccagc acctcctgcg caccctcaat cagtccagcg atgagctgca      480

gctgagtatg ggaaatgcca tgtttgtcaa agagcaactc agtctgctgg acaggttcac      540

ggaggatgcc aagaggctgt atggctccga ggcctttgcc actgactttc aggactcagc      600

tgcagctaag aagctcatca acgactacgt gaagaatgga actaggggga aaatcacaga      660

tctgatcaag gaccttgact cgcagacaat gatggtcctg gtgaattaca tcttctttaa      720

agccaaatgg gagatgccct ttgaccccca agatactcat cagtcaaggt tctacttgag      780

caagaaaaag tgggtaatgg tgcccatgat gagtttgcat cacctgacta taccttactt      840

ccgggacgag gagctgtcct gcaccgtggt ggagctgaag tacacaggca atgccagcgc      900

actcttcatc ctccctgatc aagacaagat ggaggaagtg gaagccatgc tgctcccaga      960

gaccctgaag cggtggagag actctctgga gttcagagag ataggtgagc tctacctgcc     1020

aaagttttcc atctcgaggg actataacct gaacgacata cttctccagc tgggcattga     1080

ggaagccttc accagcaagg ctgacctgtc agggatcaca ggggccagga acctagcagt     1140

ctcccaggtg gtccataagg ctgtgcttga tgtatttgag gagggcacag aagcatctgc     1200

tgccacagca gtcaaaatca ccctcctttc tgcattagtg gagacaagga ccattgtgcg     1260

tttcaacagg cccttcctga tgatcattgt ccctacagac acccagaaca tcttcttcat     1320

gagcaaagtc accaatccca agcaagccta gagcttgcca tcaagcagtg gggctctcag     1380

taaggaactt ggaatgcaag ctggatgcct gggtctctgg gcacagcctg gcccctgtgc     1440

accgagtggc catggcatgt gtggccctgt ctgcttatcc ttggaaggtg acagcgattc     1500

cctgtgtagc tctcacatgc acaggggccc atggactctt cagtctggag ggtcctgggc     1560

ctcctgacag caataaataa tttcgttgga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaa                                                             1629


<210>  80
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Glu Arg Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala Gly 
1               5                   10                  15      


Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu 
            20                  25                  30          


Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly 
        35                  40                  45              


Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu 
    50                  55                  60                  


Val Leu Lys Ala Pro Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile 
65                  70                  75                  80  


Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu 
                85                  90                  95      


Thr Glu Ile Leu Lys Gly Leu Lys Phe Asn Leu Thr Glu Thr Ser Glu 
            100                 105                 110         


Ala Glu Ile His Gln Ser Phe Gln His Leu Leu Arg Thr Leu Asn Gln 
        115                 120                 125             


Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val Lys 
    130                 135                 140                 


Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu 
145                 150                 155                 160 


Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala 
                165                 170                 175     


Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile 
            180                 185                 190         


Thr Asp Leu Ile Lys Asp Leu Asp Ser Gln Thr Met Met Val Leu Val 
        195                 200                 205             


Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln 
    210                 215                 220                 


Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val Met 
225                 230                 235                 240 


Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg Asp 
                245                 250                 255     


Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala 
            260                 265                 270         


Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val Glu 
        275                 280                 285             


Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu 
    290                 295                 300                 


Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg 
305                 310                 315                 320 


Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala 
                325                 330                 335     


Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu 
            340                 345                 350         


Ala Val Ser Gln Val Val His Lys Ala Val Leu Asp Val Phe Glu Glu 
        355                 360                 365             


Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Lys Ile Thr Leu Leu Ser 
    370                 375                 380                 


Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu 
385                 390                 395                 400 


Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys 
                405                 410                 415     


Val Thr Asn Pro Lys Gln Ala 
            420             


<210>  81
<211>  4380
<212>  DNA
<213>  Homo sapiens

<400>  81
ggggagcgcc atccgctcca cttccacctc cacatcctcc accggccaag gtccccgccg       60

ctgcatccct cgcggcttcc gctgcgctcc gggccggagc cgagccgcct gcgctgccac      120

agcagccgcc tccacacact cgcagacgct cacacgctct ccctccctgt tcccccgccc      180

cctccccagc tccttgatct ctgggtctgt tttattactc ctggtgcgag tcccgcggac      240

tccgcggccc gctatttgtc atcagctcgc tctccattgg cggggagcgg agagcagcga      300

agaagggggt ggggagggga ggggaaggga agggggtgga aactgcctgg agccgtttct      360

ccgcgccgct gttggtgctg ccgctgcctc ctcctcctcc gccgccgccg ccgccgccgc      420

cgcctcctcc ggctcttcgc tcggcccctc tccgcctcca tgtgccggat agcgggagcg      480

ctgcggaccc tgctgccgct gctggcggcc ctgcttcagg cgtctgtaga ggcttctggt      540

gaaatcgcat tatgcaagac tggatttcct gaagatgttt acagtgcagt cttatcgaag      600

gatgtgcatg aaggacagcc tcttctcaat gtgaagttta gcaactgcaa tggaaaaaga      660

aaagtacaat atgagagcag tgagcctgca gattttaagg tggatgaaga tggcatggtg      720

tatgccgtga gaagctttcc actctcttct gagcatgcca agttcctgat atatgcccaa      780

gacaaagaga cccaggaaaa gtggcaagtg gcagtaaaat tgagcctgaa gccaacctta      840

actgaggagt cagtgaagga gtcagcagaa gttgaagaaa tagtgttccc aagacaattc      900

agtaagcaca gtggccacct acaaaggcag aagagagact gggtcatccc tccaatcaac      960

ttgccagaaa actccagggg accttttcct caagagcttg tcaggatcag gtctgataga     1020

gataaaaacc tttcactgcg gtacagtgta actgggccag gagctgacca gcctccaact     1080

ggtatcttca ttatcaaccc catctcgggt cagctgtcgg tgacaaagcc cctggatcgc     1140

gagcagatag cccggtttca tttgagggca catgcagtag atattaatgg aaatcaagtg     1200

gagaacccca ttgacattgt catcaatgtt attgacatga atgacaacag acctgagttc     1260

ttacaccagg tttggaatgg gacagttcct gagggatcaa agcctggaac atatgtgatg     1320

accgtaacag caattgatgc tgacgatccc aatgccctca atgggatgtt gaggtacaga     1380

atcgtgtctc aggctccaag caccccttca cccaacatgt ttacaatcaa caatgagact     1440

ggtgacatca tcacagtggc agctggactt gatcgagaaa aagtgcaaca gtatacgtta     1500

ataattcaag ctacagacat ggaaggcaat cccacatatg gcctttcaaa cacagccacg     1560

gccgtcatca cagtgacaga tgtcaatgac aatcctccag agtttactgc catgacgttt     1620

tatggtgaag ttcctgagaa cagggtagac atcatagtag ctaatctaac tgtgaccgat     1680

aaggatcaac cccatacacc agcctggaac gcagtgtaca gaatcagtgg cggagatcct     1740

actggacggt tcgccatcca gaccgaccca aacagcaacg acgggttagt caccgtggtc     1800

aaaccaatcg actttgaaac aaataggatg tttgtcctta ctgttgctgc agaaaatcaa     1860

gtgccattag ccaagggaat tcagcacccg cctcagtcaa ctgcaaccgt gtctgttaca     1920

gttattgacg taaatgaaaa cccttatttt gcccccaatc ctaagatcat tcgccaagaa     1980

gaagggcttc atgccggtac catgttgaca acattcactg ctcaggaccc agatcgatat     2040

atgcagcaaa atattagata cactaaatta tctgatcctg ccaattggct aaaaatagat     2100

cctgtgaatg gacaaataac tacaattgct gttttggacc gagaatcacc aaatgtgaaa     2160

aacaatatat ataatgctac tttccttgct tctgacaatg gaattcctcc tatgagtgga     2220

acaggaacgc tgcagatcta tttacttgat attaatgaca atgcccctca agtgttacct     2280

caagaggcag agacttgcga aactccagac cccaattcaa ttaatattac agcacttgat     2340

tatgacattg atccaaatgc tggaccattt gcttttgatc ttcctttatc tccagtgact     2400

attaagagaa attggaccat cactcggctt aatggtgatt ttgctcagct taatttaaag     2460

ataaaatttc ttgaagctgg tatctatgaa gttcccatca taatcacaga ttcgggtaat     2520

cctcccaaat caaatatttc catcctgcgc gtgaaggttt gccagtgtga ctccaacggg     2580

gactgcacag atgtggacag gattgtgggt gcggggcttg gcaccggtgc catcattgcc     2640

atcctgctct gcatcatcat cctgcttatc cttgtgctga tgtttgtggt atggatgaaa     2700

cgccgggata aagaacgcca ggccaaacaa cttttaattg atccagaaga tgatgtaaga     2760

gataatattt taaaatatga tgaagaaggt ggaggagaag aagaccagga ctatgacttg     2820

agccagctgc agcagcctga cactgtggag cctgatgcca tcaagcctgt gggaatccga     2880

cgaatggatg aaagacccat ccacgccgag ccccagtatc cggtccgatc tgcagcccca     2940

caccctggag acattgggga cttcattaat gagggcctta aagcggctga caatgacccc     3000

acagctccac catatgactc cctgttagtg tttgactatg aaggcagtgg ctccactgct     3060

gggtccttga gctcccttaa ttcctcaagt agtggtggtg agcaggacta tgattacctg     3120

aacgactggg ggccacggtt caagaaactt gctgacatgt atggtggagg tgatgactga     3180

acttcagggt gaacttggtt tttggacaag tacaaacaat ttcaactgat attcccaaaa     3240

agcattcaga agctaggctt taactttgta gtctactagc acagtgcttg ctggaggctt     3300

tggcataggc tgcaaaccaa tttgggctca gagggaatat cagtgatcca tactgtttgg     3360

aaaaacactg agctcagtta cacttgaatt ttacagtaca gaagcactgg gattttatgt     3420

gcctttttgt acctttttca gattggaatt agttttctgt ttaaggcttt aatggtactg     3480

atttctgaaa cgataagtaa aagacaaaat attttgtggt gggagcagta agttaaacca     3540

tgatatgctt caacacgctt ttgttacatt gcatttgctt ttattaaaat acaaaattaa     3600

acaaacaaaa aaactcatgg agcgatttta ttatcttggg ggatgagacc atgagattgg     3660

aaaatgtaca ttacttctag ttttagactt tagtttgttt tttttttttt cactaaaatc     3720

ttaaaactta ctcagctggt tgcaaataaa gggagttttc atatcaccaa tttgtagcaa     3780

aattgaattt tttcataaac tagaatgtta gacacatttt ggtcttaatc catgtacact     3840

tttttatttc tgtatttttc cacttcactg taaaaatagt atgtgtacat aatgttttat     3900

tggcatagtc tatggagaag tgcagaaact tcagaacatg tgtatgtatt atttggacta     3960

tggattcagg ttttttgcat gtttatatct ttcgttatgg ataaagtatt tacaaaacag     4020

tgacatttga ttcaattgtt gagctgtagt tagaatactc aatttttaat ttttttaatt     4080

tttttatttt ttattttctt tttggtttgg ggagggagaa aagttcttag cacaaatgtt     4140

ttacataatt tgtaccaaaa aaaaaaaaaa aggaaaggaa agaaaggggt ggcctgacac     4200

tggtggcact actaagtgtg tgttttttta aaaaaaaaat ggaaaaaaaa aagcttttaa     4260

actggagaga cttctgacaa cagctttgcc tctgtattgt gtaccagaat ataaatgata     4320

cacctctgac cccagcgttc tgaataaaat gctaattttg gatctggaaa aaaaaaaaaa     4380


<210>  82
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Cys Arg Ile Ala Gly Ala Leu Arg Thr Leu Leu Pro Leu Leu Ala 
1               5                   10                  15      


Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys 
            20                  25                  30          


Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Ser Lys Asp 
        35                  40                  45              


Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
    50                  55                  60                  


Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
65                  70                  75                  80  


Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                85                  90                  95      


Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
            100                 105                 110         


Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Thr Leu Thr 
        115                 120                 125             


Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro 
    130                 135                 140                 


Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp 
145                 150                 155                 160 


Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                165                 170                 175     


Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
            180                 185                 190         


Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
        195                 200                 205             


Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
    210                 215                 220                 


Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
225                 230                 235                 240 


Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                245                 250                 255     


Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
            260                 265                 270         


Asn Gly Thr Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
        275                 280                 285             


Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
    290                 295                 300                 


Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
305                 310                 315                 320 


Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                325                 330                 335     


Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
            340                 345                 350         


Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
        355                 360                 365             


Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
    370                 375                 380                 


Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile Val 
385                 390                 395                 400 


Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                405                 410                 415     


Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
            420                 425                 430         


Ile Gln Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
        435                 440                 445             


Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
    450                 455                 460                 


Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
465                 470                 475                 480 


Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                485                 490                 495     


Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
            500                 505                 510         


Gly Thr Met Leu Thr Thr Phe Thr Ala Gln Asp Pro Asp Arg Tyr Met 
        515                 520                 525             


Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
    530                 535                 540                 


Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
545                 550                 555                 560 


Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                565                 570                 575     


Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
            580                 585                 590         


Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
        595                 600                 605             


Glu Ala Glu Thr Cys Glu Thr Pro Asp Pro Asn Ser Ile Asn Ile Thr 
    610                 615                 620                 


Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
625                 630                 635                 640 


Leu Pro Leu Ser Pro Val Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                645                 650                 655     


Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
            660                 665                 670         


Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Thr Asp Ser Gly Asn Pro 
        675                 680                 685             


Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
    690                 695                 700                 


Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
705                 710                 715                 720 


Gly Thr Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                725                 730                 735     


Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
            740                 745                 750         


Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
        755                 760                 765             


Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
    770                 775                 780                 


Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
785                 790                 795                 800 


Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His Ala 
                805                 810                 815     


Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
            820                 825                 830         


Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
        835                 840                 845             


Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
    850                 855                 860                 


Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
865                 870                 875                 880 


Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                885                 890                 895     


Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
            900                 905     


<210>  83
<211>  3063
<212>  DNA
<213>  Homo sapiens

<400>  83
cgccggcggg gaagatgacc gcgggcgccg gcgtgctcct tctgctgctc tcgctctccg       60

gcgcgctccg ggcccataat gaggatctta caactagaga gacctgcaag gctgggttct      120

ctgaagatga ttacacggca ttaatctccc aaaatattct agaaggggaa aagctacttc      180

aagtcaagtt cagcagctgt gtggggacca aggggacaca atatgagacc aacagcatgg      240

acttcaaagt tggggcagat gggacagtct tcgccacccg ggagctgcag gtcccctccg      300

agcaggtggc gttcacggtg actgcatggg acagccagac agcagagaaa tgggacgccg      360

tggtgcggtt gctggtggcc cagacctcgt ccccgcactc tggacacaag ccgcagaaag      420

gaaagaaggt cgtggctctg gacccctctc cgcctccgaa ggacaccctg ctgccgtggc      480

cccagcacca gaacgccaac gggctgaggc ggcgcaaacg ggactgggtc atcccgccca      540

tcaacgtgcc cgagaactcg cgcgggccct tcccgcagca gctcgtgagg atccggtccg      600

acaaagacaa tgacatcccc atccggtaca gcatcacggg agtgggcgcc gaccagcccc      660

ccatggaggt cttcagcatt gactccatgt ccggccggat gtacgtcaca aggcccatgg      720

accgggagga gcacgcctct taccacctcc gagcccacgc tgtggacatg aatggcaaca      780

aggtggagaa ccccatcgac ctgtacatct acgtcatcga catgaatgac aaccgccctg      840

agttcatcaa ccaggtctac aacggctccg tggacgaggg ctccaagcca ggcacctacg      900

tgatgaccgt cacggccaac gatgctgacg acagcaccac ggccaacggg atggtgcggt      960

accggatcgt gacccagacc ccacagagcc cgtcccagaa tatgttcacc atcaacagcg     1020

agactggaga tatcgtcaca gtggcggctg gcctggaccg agagaaagtt cagcagtaca     1080

cagtcatcgt tcaggccaca gatatggaag gaaatctcaa ctatggcctc tcaaacacag     1140

ccacagccat catcacggtg acagatgtga atgacaaccc gccagaattt accgccagca     1200

cgtttgcagg ggaggtcccc gaaaaccgcg tggagaccgt ggtcgcaaac ctcacggtga     1260

tggaccgaga tcagccccac tctccaaact ggaatgccgt ttaccgcatc atcagtgggg     1320

atccatccgg gcacttcagc gtccgcacag accccgtaac caacgagggc atggtcaccg     1380

tggtgaaggc agtcgactac gagctcaaca gagctttcat gctgacagtg atggtgtcca     1440

accaggcgcc cctggccagc ggaatccaga tgtccttcca gtccacggca ggggtgacca     1500

tctccatcat ggacatcaac gaggctccct acttcccctc aaaccacaag ctgatccgcc     1560

tggaggaggg cgtgcccccc ggcaccgtgc tgaccacgtt ttcagctgtg gaccctgacc     1620

ggttcatgca gcaggctgtg agatactcaa agctgtcaga cccagcgagc tggctgcaca     1680

tcaatgccac caacggccag atcaccacgg cggcagtgct ggaccgtgag tccctctaca     1740

ccaaaaacaa cgtctacgag gccaccttcc tggcagctga caatgggata cccccggcca     1800

gcggcaccgg gaccctccag atctatctca ttgacatcaa cgacaacgcc cctgagctgc     1860

tgcccaagga ggcgcagatc tgcgagaagc ccaacctgaa cgccatcaac atcacggcgg     1920

ccgacgctga cgtcgacccc aacatcggcc cctacgtctt cgagctgccc tttgtcccgg     1980

cggccgtgcg gaagaactgg accatcaccc gcctgaacgg tgactatgcc caactcagct     2040

tgcgcatcct gtacctggag gccgggatgt atgacgtccc catcatcgtc acagactctg     2100

gaaaccctcc cctgtccaac acgtccatca tcaaagtcaa ggtgtgccca tgtgatgaca     2160

acggggactg caccaccatt ggcgcagtgg cagcggctgg tctgggcacc ggtgccatcg     2220

tggccatcct catctgcatc ctcatcctgc tgaccatggt cctgctgttt gtcatgtgga     2280

tgaagcggcg agagaaggag cgccacacga agcagctgct cattgacccc gaggacgacg     2340

tccgcgacaa catcctcaag tatgacgagg aaggcggtgg cgaggaggac caggactacg     2400

acctcagcca gctgcagcag ccggaagcca tggggcacgt gccaagcaaa gcccctggcg     2460

tgcgtcgcgt ggatgagcgg ccggtgggcg ctgagcccca gtacccgatc aggcccatgg     2520

tgccgcaccc aggcgacatc ggtgacttca tcaatgaggg actccgcgct gctgacaacg     2580

accccacggc acccccctat gactccctgc tggtcttcga ctacgagggg agcggctcca     2640

ccgcaggctc cgtcagctcc ctgaactcat ccagttccgg ggaccaagac tacgattacc     2700

tcaacgactg ggggcccaga ttcaagaagc tggcggacat gtatggaggt ggtgaagagg     2760

attgactgac ctcgcatctt cggaccgaag tgagagccgt gctcggacgc cggaggagca     2820

ggactgagca gaggcggccg gtcttcccga ctccctgcgg ctgtgtcctt agtgctgtta     2880

ggaggccccc caatccccac gttgagctgt ctagcatgag cacccacccc cacagcgccc     2940

tgcacccggc cgctgcccag caccgcgctg gctggcactg aaggacagca agaggcactc     3000

tgtcttcact tgaatttcct agaacagaag cactgttttt aaaaaaaaaa aaaaaaaaag     3060

aag                                                                   3063


<210>  84
<211>  916
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Thr Ala Gly Ala Gly Val Leu Leu Leu Leu Leu Ser Leu Ser Gly 
1               5                   10                  15      


Ala Leu Arg Ala His Asn Glu Asp Leu Thr Thr Arg Glu Thr Cys Lys 
            20                  25                  30          


Ala Gly Phe Ser Glu Asp Asp Tyr Thr Ala Leu Ile Ser Gln Asn Ile 
        35                  40                  45              


Leu Glu Gly Glu Lys Leu Leu Gln Val Lys Phe Ser Ser Cys Val Gly 
    50                  55                  60                  


Thr Lys Gly Thr Gln Tyr Glu Thr Asn Ser Met Asp Phe Lys Val Gly 
65                  70                  75                  80  


Ala Asp Gly Thr Val Phe Ala Thr Arg Glu Leu Gln Val Pro Ser Glu 
                85                  90                  95      


Gln Val Ala Phe Thr Val Thr Ala Trp Asp Ser Gln Thr Ala Glu Lys 
            100                 105                 110         


Trp Asp Ala Val Val Arg Leu Leu Val Ala Gln Thr Ser Ser Pro His 
        115                 120                 125             


Ser Gly His Lys Pro Gln Lys Gly Lys Lys Val Val Ala Leu Asp Pro 
    130                 135                 140                 


Ser Pro Pro Pro Lys Asp Thr Leu Leu Pro Trp Pro Gln His Gln Asn 
145                 150                 155                 160 


Ala Asn Gly Leu Arg Arg Arg Lys Arg Asp Trp Val Ile Pro Pro Ile 
                165                 170                 175     


Asn Val Pro Glu Asn Ser Arg Gly Pro Phe Pro Gln Gln Leu Val Arg 
            180                 185                 190         


Ile Arg Ser Asp Lys Asp Asn Asp Ile Pro Ile Arg Tyr Ser Ile Thr 
        195                 200                 205             


Gly Val Gly Ala Asp Gln Pro Pro Met Glu Val Phe Ser Ile Asp Ser 
    210                 215                 220                 


Met Ser Gly Arg Met Tyr Val Thr Arg Pro Met Asp Arg Glu Glu His 
225                 230                 235                 240 


Ala Ser Tyr His Leu Arg Ala His Ala Val Asp Met Asn Gly Asn Lys 
                245                 250                 255     


Val Glu Asn Pro Ile Asp Leu Tyr Ile Tyr Val Ile Asp Met Asn Asp 
            260                 265                 270         


Asn Arg Pro Glu Phe Ile Asn Gln Val Tyr Asn Gly Ser Val Asp Glu 
        275                 280                 285             


Gly Ser Lys Pro Gly Thr Tyr Val Met Thr Val Thr Ala Asn Asp Ala 
    290                 295                 300                 


Asp Asp Ser Thr Thr Ala Asn Gly Met Val Arg Tyr Arg Ile Val Thr 
305                 310                 315                 320 


Gln Thr Pro Gln Ser Pro Ser Gln Asn Met Phe Thr Ile Asn Ser Glu 
                325                 330                 335     


Thr Gly Asp Ile Val Thr Val Ala Ala Gly Leu Asp Arg Glu Lys Val 
            340                 345                 350         


Gln Gln Tyr Thr Val Ile Val Gln Ala Thr Asp Met Glu Gly Asn Leu 
        355                 360                 365             


Asn Tyr Gly Leu Ser Asn Thr Ala Thr Ala Ile Ile Thr Val Thr Asp 
    370                 375                 380                 


Val Asn Asp Asn Pro Pro Glu Phe Thr Ala Ser Thr Phe Ala Gly Glu 
385                 390                 395                 400 


Val Pro Glu Asn Arg Val Glu Thr Val Val Ala Asn Leu Thr Val Met 
                405                 410                 415     


Asp Arg Asp Gln Pro His Ser Pro Asn Trp Asn Ala Val Tyr Arg Ile 
            420                 425                 430         


Ile Ser Gly Asp Pro Ser Gly His Phe Ser Val Arg Thr Asp Pro Val 
        435                 440                 445             


Thr Asn Glu Gly Met Val Thr Val Val Lys Ala Val Asp Tyr Glu Leu 
    450                 455                 460                 


Asn Arg Ala Phe Met Leu Thr Val Met Val Ser Asn Gln Ala Pro Leu 
465                 470                 475                 480 


Ala Ser Gly Ile Gln Met Ser Phe Gln Ser Thr Ala Gly Val Thr Ile 
                485                 490                 495     


Ser Ile Met Asp Ile Asn Glu Ala Pro Tyr Phe Pro Ser Asn His Lys 
            500                 505                 510         


Leu Ile Arg Leu Glu Glu Gly Val Pro Pro Gly Thr Val Leu Thr Thr 
        515                 520                 525             


Phe Ser Ala Val Asp Pro Asp Arg Phe Met Gln Gln Ala Val Arg Tyr 
    530                 535                 540                 


Ser Lys Leu Ser Asp Pro Ala Ser Trp Leu His Ile Asn Ala Thr Asn 
545                 550                 555                 560 


Gly Gln Ile Thr Thr Ala Ala Val Leu Asp Arg Glu Ser Leu Tyr Thr 
                565                 570                 575     


Lys Asn Asn Val Tyr Glu Ala Thr Phe Leu Ala Ala Asp Asn Gly Ile 
            580                 585                 590         


Pro Pro Ala Ser Gly Thr Gly Thr Leu Gln Ile Tyr Leu Ile Asp Ile 
        595                 600                 605             


Asn Asp Asn Ala Pro Glu Leu Leu Pro Lys Glu Ala Gln Ile Cys Glu 
    610                 615                 620                 


Lys Pro Asn Leu Asn Ala Ile Asn Ile Thr Ala Ala Asp Ala Asp Val 
625                 630                 635                 640 


Asp Pro Asn Ile Gly Pro Tyr Val Phe Glu Leu Pro Phe Val Pro Ala 
                645                 650                 655     


Ala Val Arg Lys Asn Trp Thr Ile Thr Arg Leu Asn Gly Asp Tyr Ala 
            660                 665                 670         


Gln Leu Ser Leu Arg Ile Leu Tyr Leu Glu Ala Gly Met Tyr Asp Val 
        675                 680                 685             


Pro Ile Ile Val Thr Asp Ser Gly Asn Pro Pro Leu Ser Asn Thr Ser 
    690                 695                 700                 


Ile Ile Lys Val Lys Val Cys Pro Cys Asp Asp Asn Gly Asp Cys Thr 
705                 710                 715                 720 


Thr Ile Gly Ala Val Ala Ala Ala Gly Leu Gly Thr Gly Ala Ile Val 
                725                 730                 735     


Ala Ile Leu Ile Cys Ile Leu Ile Leu Leu Thr Met Val Leu Leu Phe 
            740                 745                 750         


Val Met Trp Met Lys Arg Arg Glu Lys Glu Arg His Thr Lys Gln Leu 
        755                 760                 765             


Leu Ile Asp Pro Glu Asp Asp Val Arg Asp Asn Ile Leu Lys Tyr Asp 
    770                 775                 780                 


Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Leu Ser Gln Leu 
785                 790                 795                 800 


Gln Gln Pro Glu Ala Met Gly His Val Pro Ser Lys Ala Pro Gly Val 
                805                 810                 815     


Arg Arg Val Asp Glu Arg Pro Val Gly Ala Glu Pro Gln Tyr Pro Ile 
            820                 825                 830         


Arg Pro Met Val Pro His Pro Gly Asp Ile Gly Asp Phe Ile Asn Glu 
        835                 840                 845             


Gly Leu Arg Ala Ala Asp Asn Asp Pro Thr Ala Pro Pro Tyr Asp Ser 
    850                 855                 860                 


Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Thr Ala Gly Ser Val 
865                 870                 875                 880 


Ser Ser Leu Asn Ser Ser Ser Ser Gly Asp Gln Asp Tyr Asp Tyr Leu 
                885                 890                 895     


Asn Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly 
            900                 905                 910         


Gly Glu Glu Asp 
        915     


<210>  85
<211>  2875
<212>  DNA
<213>  Homo sapiens

<400>  85
acttgcgctg tcactcagcc tggacgcgct tcttcgggtc gcgggtgcac tccggcccgg       60

ctcccgcctc ggccccgatg gacgccgcgt tcctcctcgt cctcgggctg ttggcccaga      120

gcctctgcct gtctttgggg gttcctggat ggaggaggcc caccaccctg tacccctggc      180

gccgggcgcc tgccctgagc cgcgtgcgga gggcctgggt catccccccg atcagcgtat      240

ccgagaacca caagcgtctc ccctaccccc tggttcagat caagtcggac aagcagcagc      300

tgggcagcgt catctacagc atccagggac ccggcgtgga tgaggagccc cggggcgtct      360

tctctatcga caagttcaca gggaaggtct tcctcaatgc catgctggac cgcgagaaga      420

ctgatcgctt caggctaaga gcgtttgccc tggacctggg aggatccacc ctggaggacc      480

ccacggacct ggagattgta gttgtggatc agaatgacaa ccggccagcc ttcctgcagg      540

aggcgttcac tggccgcgtg ctggagggtg cagtcccagg cacctatgtg accagggcag      600

aggccacaga tgccgacgac cccgagacgg acaacgcagc gctgcggttc tccatcctgc      660

agcagggcag ccccgagctc ttcagcatcg acgagctcac aggagagatc cgcacagtgc      720

aagtggggct ggaccgcgag gtggtcgcgg tgtacaatct gaccctgcag gtggcggaca      780

tgtctggaga cggcctcaca gccactgcct cagccatcat cacccttgat gacatcaatg      840

acaatgcccc cgagttcacc agggatgagt tcttcatgga ggccatagag gccgtcagcg      900

gagtggatgt gggacgcctg gaagtggagg acagggacct gccaggctcc ccaaactggg      960

tggccaggtt caccatcctg gaaggcgacc ccgatgggca gttcaccatc cgcacggacc     1020

ccaagaccaa cgagggtgtt ctgtccattg tgaaggccct ggactatgag agctgtgaac     1080

actacgaact caaagtgtcg gtgcagaatg aggccccgct gcaggcggct gcccttaggg     1140

ctgagcgggg ccaggccaag gtccgcgtgc atgtgcagga caccaacgag ccccccgtgt     1200

tccaggagaa cccacttcgg accagcctag cagagggggc acccccaggc actctggtgg     1260

ccaccttctc tgcccgggac cctgacacag agcagctgca gaggctcagc tactccaagg     1320

actacgaccc ggaagactgg ctgcaagtgg acgcagccac tggccggatc cagacccagc     1380

acgtgctcag cccggcgtcc cccttcctca agggcggctg gtacagagcc atcgtcctgg     1440

cccaggatga cgcctcccag ccccgcaccg ccaccggcac cctgtccatc gagatcctgg     1500

aggtgaacga ccatgcacct gtgctggccc cgccgccgcc gggcagcctg tgcagcgagc     1560

cacaccaagg cccaggcctc ctcctgggcg ccacggatga ggacctgccc ccccacgggg     1620

cccccttcca cttccagctg agccccaggc tcccagagct cggccggaac tggagcctca     1680

gccaggtcaa cgtgagccac gcgcgcctgc ggccgcgaca ccaggtcccc gaaggcctgc     1740

accgcctcag cctgctgctc cgggactcgg ggcagccgcc ccagcagcgc gagcagcctc     1800

tgaacgtgac cgtgtgccgc tgcggcaagg acggcgtctg cctgccgggg gccgcagcgc     1860

tgctggcggg gggcacaggc ctcagcctgg gcgcactggt catcgtgctg gccagcgccc     1920

tcctgctgct ggtgctggtc ctgctcgtgg cactccgggc gcggttctgg aagcagtctc     1980

ggggcaaggg gctgctgcac ggcccccagg acgaccttcg agacaatgtc ctcaactacg     2040

atgagcaagg aggcggggag gaggaccagg acgcctacga catcagccag ctgcgtcacc     2100

cgacagcgct gagcctgcct ctgggaccgc cgccacttcg cagagatgcc ccgcagggcc     2160

gcctgcaccc ccagccaccc cgagtgctgc ccaccagccc cctggacatc gccgacttca     2220

tcaatgatgg cttggaggct gcagatagtg accccagtgt gccgccttac gacacagccc     2280

tcatctatga ctacgagggt gacggctcgg tggcggggac gctgagctcc atcctgtcca     2340

gccagggcga tgaggaccag gactacgact acctcagaga ctgggggccc cgcttcgccc     2400

ggctggcaga catgtatggg cacccgtgcg ggttggagta cggggccaga tgggaccacc     2460

aggccaggga gggtctttct cctggggcac tgctacccag acacagaggc cggacagcct     2520

gaccctgggg cgcaactgga catgccactc cccggcctcg tggcagtgat ggcccctgca     2580

gaggcagcct gaggtcaccg ggcccgaccc ccctgggcct ggggcagcct ccttcctgta     2640

ggcgagggcc caagtctggg ggcagaacct gagtgtggat ggggcggcca ggaagaggcc     2700

ccttcctgcc ggggtgggaa gagtttctct ccatcggccc catgcgggtc acctccctag     2760

tcccaccttt gcctcctacc agtgaacctc atctttgtat gaaagacagc aacctcctgg     2820

gtaaatctga atgaaaaacg tgctagtctc tttcatgcaa aaaaaaaaaa aaaaa          2875


<210>  86
<211>  814
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Asp Ala Ala Phe Leu Leu Val Leu Gly Leu Leu Ala Gln Ser Leu 
1               5                   10                  15      


Cys Leu Ser Leu Gly Val Pro Gly Trp Arg Arg Pro Thr Thr Leu Tyr 
            20                  25                  30          


Pro Trp Arg Arg Ala Pro Ala Leu Ser Arg Val Arg Arg Ala Trp Val 
        35                  40                  45              


Ile Pro Pro Ile Ser Val Ser Glu Asn His Lys Arg Leu Pro Tyr Pro 
    50                  55                  60                  


Leu Val Gln Ile Lys Ser Asp Lys Gln Gln Leu Gly Ser Val Ile Tyr 
65                  70                  75                  80  


Ser Ile Gln Gly Pro Gly Val Asp Glu Glu Pro Arg Gly Val Phe Ser 
                85                  90                  95      


Ile Asp Lys Phe Thr Gly Lys Val Phe Leu Asn Ala Met Leu Asp Arg 
            100                 105                 110         


Glu Lys Thr Asp Arg Phe Arg Leu Arg Ala Phe Ala Leu Asp Leu Gly 
        115                 120                 125             


Gly Ser Thr Leu Glu Asp Pro Thr Asp Leu Glu Ile Val Val Val Asp 
    130                 135                 140                 


Gln Asn Asp Asn Arg Pro Ala Phe Leu Gln Glu Ala Phe Thr Gly Arg 
145                 150                 155                 160 


Val Leu Glu Gly Ala Val Pro Gly Thr Tyr Val Thr Arg Ala Glu Ala 
                165                 170                 175     


Thr Asp Ala Asp Asp Pro Glu Thr Asp Asn Ala Ala Leu Arg Phe Ser 
            180                 185                 190         


Ile Leu Gln Gln Gly Ser Pro Glu Leu Phe Ser Ile Asp Glu Leu Thr 
        195                 200                 205             


Gly Glu Ile Arg Thr Val Gln Val Gly Leu Asp Arg Glu Val Val Ala 
    210                 215                 220                 


Val Tyr Asn Leu Thr Leu Gln Val Ala Asp Met Ser Gly Asp Gly Leu 
225                 230                 235                 240 


Thr Ala Thr Ala Ser Ala Ile Ile Thr Leu Asp Asp Ile Asn Asp Asn 
                245                 250                 255     


Ala Pro Glu Phe Thr Arg Asp Glu Phe Phe Met Glu Ala Ile Glu Ala 
            260                 265                 270         


Val Ser Gly Val Asp Val Gly Arg Leu Glu Val Glu Asp Arg Asp Leu 
        275                 280                 285             


Pro Gly Ser Pro Asn Trp Val Ala Arg Phe Thr Ile Leu Glu Gly Asp 
    290                 295                 300                 


Pro Asp Gly Gln Phe Thr Ile Arg Thr Asp Pro Lys Thr Asn Glu Gly 
305                 310                 315                 320 


Val Leu Ser Ile Val Lys Ala Leu Asp Tyr Glu Ser Cys Glu His Tyr 
                325                 330                 335     


Glu Leu Lys Val Ser Val Gln Asn Glu Ala Pro Leu Gln Ala Ala Ala 
            340                 345                 350         


Leu Arg Ala Glu Arg Gly Gln Ala Lys Val Arg Val His Val Gln Asp 
        355                 360                 365             


Thr Asn Glu Pro Pro Val Phe Gln Glu Asn Pro Leu Arg Thr Ser Leu 
    370                 375                 380                 


Ala Glu Gly Ala Pro Pro Gly Thr Leu Val Ala Thr Phe Ser Ala Arg 
385                 390                 395                 400 


Asp Pro Asp Thr Glu Gln Leu Gln Arg Leu Ser Tyr Ser Lys Asp Tyr 
                405                 410                 415     


Asp Pro Glu Asp Trp Leu Gln Val Asp Ala Ala Thr Gly Arg Ile Gln 
            420                 425                 430         


Thr Gln His Val Leu Ser Pro Ala Ser Pro Phe Leu Lys Gly Gly Trp 
        435                 440                 445             


Tyr Arg Ala Ile Val Leu Ala Gln Asp Asp Ala Ser Gln Pro Arg Thr 
    450                 455                 460                 


Ala Thr Gly Thr Leu Ser Ile Glu Ile Leu Glu Val Asn Asp His Ala 
465                 470                 475                 480 


Pro Val Leu Ala Pro Pro Pro Pro Gly Ser Leu Cys Ser Glu Pro His 
                485                 490                 495     


Gln Gly Pro Gly Leu Leu Leu Gly Ala Thr Asp Glu Asp Leu Pro Pro 
            500                 505                 510         


His Gly Ala Pro Phe His Phe Gln Leu Ser Pro Arg Leu Pro Glu Leu 
        515                 520                 525             


Gly Arg Asn Trp Ser Leu Ser Gln Val Asn Val Ser His Ala Arg Leu 
    530                 535                 540                 


Arg Pro Arg His Gln Val Pro Glu Gly Leu His Arg Leu Ser Leu Leu 
545                 550                 555                 560 


Leu Arg Asp Ser Gly Gln Pro Pro Gln Gln Arg Glu Gln Pro Leu Asn 
                565                 570                 575     


Val Thr Val Cys Arg Cys Gly Lys Asp Gly Val Cys Leu Pro Gly Ala 
            580                 585                 590         


Ala Ala Leu Leu Ala Gly Gly Thr Gly Leu Ser Leu Gly Ala Leu Val 
        595                 600                 605             


Ile Val Leu Ala Ser Ala Leu Leu Leu Leu Val Leu Val Leu Leu Val 
    610                 615                 620                 


Ala Leu Arg Ala Arg Phe Trp Lys Gln Ser Arg Gly Lys Gly Leu Leu 
625                 630                 635                 640 


His Gly Pro Gln Asp Asp Leu Arg Asp Asn Val Leu Asn Tyr Asp Glu 
                645                 650                 655     


Gln Gly Gly Gly Glu Glu Asp Gln Asp Ala Tyr Asp Ile Ser Gln Leu 
            660                 665                 670         


Arg His Pro Thr Ala Leu Ser Leu Pro Leu Gly Pro Pro Pro Leu Arg 
        675                 680                 685             


Arg Asp Ala Pro Gln Gly Arg Leu His Pro Gln Pro Pro Arg Val Leu 
    690                 695                 700                 


Pro Thr Ser Pro Leu Asp Ile Ala Asp Phe Ile Asn Asp Gly Leu Glu 
705                 710                 715                 720 


Ala Ala Asp Ser Asp Pro Ser Val Pro Pro Tyr Asp Thr Ala Leu Ile 
                725                 730                 735     


Tyr Asp Tyr Glu Gly Asp Gly Ser Val Ala Gly Thr Leu Ser Ser Ile 
            740                 745                 750         


Leu Ser Ser Gln Gly Asp Glu Asp Gln Asp Tyr Asp Tyr Leu Arg Asp 
        755                 760                 765             


Trp Gly Pro Arg Phe Ala Arg Leu Ala Asp Met Tyr Gly His Pro Cys 
    770                 775                 780                 


Gly Leu Glu Tyr Gly Ala Arg Trp Asp His Gln Ala Arg Glu Gly Leu 
785                 790                 795                 800 


Ser Pro Gly Ala Leu Leu Pro Arg His Arg Gly Arg Thr Ala 
                805                 810                 


<210>  87
<211>  2947
<212>  DNA
<213>  Homo sapiens

<400>  87
ctcctcccgg gcgggataat tgaacggcgc ggccctggcc cagcgttggc tgccgaggct       60

cggccggagc gtggagcccg cgccgctgcc ccaggaccgc gcccgcgcct ttgtccgccg      120

ccgcccaccg cccgtcgccc gccgcccatg gagcgcgccg cgccgtcgcg ccgggtcccg      180

cttccgctgc tgctgctcgg cggccttgcg ctgctggcgg ccggagtgga cgcggatgtc      240

ctcctggagg cctgctgtgc ggacggacac cggatggcca ctcatcagaa ggactgctcg      300

ctgccatatg ctacggaatc caaagaatgc aggatggtgc aggagcagtg ctgccacagc      360

cagctggagg agctgcactg tgccacgggc atcagcctgg ccaacgagca ggaccgctgt      420

gccacgcccc acggtgacaa cgccagcctg gaggccacat ttgtgaagag gtgctgccat      480

tgctgtctgc tggggagggc ggcccaggcc cagggccaga gctgcgagta cagcctcatg      540

gttggctacc agtgtggaca ggtcttccgg gcatgctgtg tcaagagcca ggagaccgga      600

gatttggatg tcgggggcct ccaagaaacg gataagatca ttgaggttga ggaggaacaa      660

gaggacccat atctgaatga ccgctgccga ggaggcgggc cctgcaagca gcagtgccga      720

gacacgggtg acgaggtggt ctgctcctgc ttcgtgggct accagctgct gtctgatggt      780

gtctcctgtg aagatgtcaa tgaatgcatc acgggcagcc acagctgccg gcttggagaa      840

tcctgcatca acacagtggg ctctttccgc tgccagcggg acagcagctg cgggactggc      900

tatgagctca cagaggacaa tagctgcaaa gatattgacg agtgtgagag tggtattcat      960

aactgcctcc ccgattttat ctgtcagaat actctgggat ccttccgctg ccgacccaag     1020

ctacagtgca agagtggctt tatacaagat gctctaggca actgtattga tatcaatgag     1080

tgtttgagta tcagtgcccc gtgccctatc gggcatacat gcatcaacac agagggctcc     1140

tacacgtgcc agaagaacgt gcccaactgt ggccgtggct accatctcaa cgaggaggga     1200

acgcgctgtg ttgatgtgga cgagtgcgcg ccacctgctg agccctgtgg gaagggacat     1260

cgctgcgtga actctcccgg cagtttccgc tgcgaatgca agacgggtta ctattttgac     1320

ggcatcagca ggatgtgtgt cgatgtcaac gagtgccagc gctaccccgg gcgcctgtgt     1380

ggccacaagt gcgagaacac gctgggctcc tacctctgca gctgttccgt gggcttccgg     1440

ctctctgtgg atggcaggtc atgtgaagac atcaatgagt gcagcagcag cccctgtagc     1500

caggagtgtg ccaacgtcta cggctcctac cagtgttact gccggcgagg ctaccagctc     1560

agcgatgtgg atggagtcac ctgtgaagac atcgacgagt gcgccctgcc caccgggggc     1620

cacatctgct cctaccgctg catcaacatc cctggaagct tccagtgcag ctgcccctcg     1680

tctggctaca ggctggcccc caatggccgc aactgccaag acattgatga gtgtgtgact     1740

ggcatccaca actgctccat caacgagacc tgcttcaaca tccagggcgg cttccgctgc     1800

ctggccttcg agtgccctga gaactaccgc cgctccgcag ccacgctcca gcaggagaag     1860

acagacacgg tccgctgcat caagtcctgc cgccccaacg atgtcacatg cgtgttcgac     1920

cccgtgcaca ccatctccca caccgtcatc tcgctgccta ccttccgcga gttcacccgc     1980

cctgaagaga tcatcttcct ccgggccatc acgccaccgc atcctgccag ccaggctaac     2040

atcatcttcg acatcacgga agggaacctg cgggactctt ttgacatcat caagcgttac     2100

atggacggca tgaccgtggg tgtcgtgcgc caggtgcggc ccatcgtggg cccatttcat     2160

gccgtcctga agctggagat gaactatgtg gtcgggggcg tggtctccca ccgaaatgtt     2220

gtcaacgtcc acatcttcgt ctctgagtac tggttctgag ggctggtctg ccgcacagcc     2280

gcaggtgcac ctccaggcca aatcattgct gccagtgact gtggtctgta cttgtttata     2340

ccctcagact tttttaatgt taggtatttg tagcattagg ccaacatgta ttaagctgag     2400

ccagatgaat aagtccatct gatgtatttt cggtgtttaa aaaatgagcc cagttgctca     2460

actgtttggt tgaaaacctt gctcattttt taatgcgaag gctaagtgtc accccctttc     2520

tctgcctctg gctgggcctt gctaagggcc aaggaaagaa agacattttt tagggggcag     2580

ccagtccaaa tgccaaaaga agaccagttc ttgccctgat tgtatgaaat ttgacatttt     2640

ggcacttttt tttttttttt ggccaatcag attttctatg ttctaaggac atggctgctg     2700

tagaatagca cagacgtgga tgataaatta tccccagaag cagcatgaca gaatgcctcg     2760

gggagcactt ggaagggaaa ttgcagttct gttgaaatag aggaaaatcc cttggtaaag     2820

acacagcctg ttaggctcgt gtgggcctcc agtatgttca ccaggggaat ggctgggatt     2880

tctcggcact ctgcatcatc catcttttct tataggtggg aaaataaaca actttgtgat     2940

cctcctg                                                               2947


<210>  88
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr Leu Gln Gln Glu Lys Thr Asp Thr Val Arg 
                565                 570                 575     


Cys Ile Lys Ser Cys Arg Pro Asn Asp Val Thr Cys Val Phe Asp Pro 
            580                 585                 590         


Val His Thr Ile Ser His Thr Val Ile Ser Leu Pro Thr Phe Arg Glu 
        595                 600                 605             


Phe Thr Arg Pro Glu Glu Ile Ile Phe Leu Arg Ala Ile Thr Pro Pro 
    610                 615                 620                 


His Pro Ala Ser Gln Ala Asn Ile Ile Phe Asp Ile Thr Glu Gly Asn 
625                 630                 635                 640 


Leu Arg Asp Ser Phe Asp Ile Ile Lys Arg Tyr Met Asp Gly Met Thr 
                645                 650                 655     


Val Gly Val Val Arg Gln Val Arg Pro Ile Val Gly Pro Phe His Ala 
            660                 665                 670         


Val Leu Lys Leu Glu Met Asn Tyr Val Val Gly Gly Val Val Ser His 
        675                 680                 685             


Arg Asn Val Val Asn Val His Ile Phe Val Ser Glu Tyr Trp Phe 
    690                 695                 700             


<210>  89
<211>  1542
<212>  DNA
<213>  Homo sapiens

<400>  89
ggtcgcttta agaaaggagt agctgtaatc tgaagcctgc tggacgctgg attagaaggc       60

agcaaaaaaa gctctgtgct ggctggagcc ccctcagtgt gcaggcttag agggactagg      120

ctgggtgtgg agctgcagcg tatccacagg ccccaggatg caggccctgg tgctactcct      180

ctgcattgga gccctcctcg ggcacagcag ctgccagaac cctgccagcc ccccggagga      240

gggctcccca gaccccgaca gcacaggggc gctggtggag gaggaggatc ctttcttcaa      300

agtccccgtg aacaagctgg cagcggctgt ctccaacttc ggctatgacc tgtaccgggt      360

gcgatccagc acgagcccca cgaccaacgt gctcctgtct cctctcagtg tggccacggc      420

cctctcggcc ctctcgctgg gagcggagca gcgaacagaa tccatcattc accgggctct      480

ctactatgac ttgatcagca gcccagacat ccatggtacc tataaggagc tccttgacac      540

ggtcactgcc ccccagaaga acctcaagag tgcctcccgg atcgtctttg agaagaagct      600

gcgcataaaa tccagctttg tggcacctct ggaaaagtca tatgggacca ggcccagagt      660

cctgacgggc aaccctcgct tggacctgca agagatcaac aactgggtgc aggcgcagat      720

gaaagggaag ctcgccaggt ccacaaagga aattcccgat gagatcagca ttctccttct      780

cggtgtggcg cacttcaagg ggcagtgggt aacaaagttt gactccagaa agacttccct      840

cgaggatttc tacttggatg aagagaggac cgtgagggtc cccatgatgt cggaccctaa      900

ggctgtttta cgctatggct tggattcaga tctcagctgc aagattgccc agctgccctt      960

gaccggaagc atgagtatca tcttcttcct gcccctgaaa gtgacccaga atttgacctt     1020

gatagaggag agcctcacct ccgagttcat tcatgacata gaccgagaac tgaagaccgt     1080

gcaggcggtc ctcactgtcc ccaagctgaa gctgagttat gaaggcgaag tcaccaagtc     1140

cctgcaggag atgaagctgc aatccttgtt tgattcacca gactttagca agatcacagg     1200

caaacccatc aagctgactc aggtggaaca ccgggctggc tttgagtgga acgaggatgg     1260

ggcgggaacc acccccagcc cagggctgca gcctgcccac ctcaccttcc cgctggacta     1320

tcaccttaac cagcctttca tcttcgtact gagggacaca gacacagggg cccttctctt     1380

cattggcaag attctggacc ccaggggccc ctaatatccc agtttaatat tccaataccc     1440

tagaagaaaa cccgagggac agcagattcc acaggacacg aaggctgccc ctgtaaggtt     1500

tcaatgcata caataaaaga gctttatccc taacttctgt ta                        1542


<210>  90
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp 
            20                  25                  30          


Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys 
        35                  40                  45              


Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp 
    50                  55                  60                  


Leu Tyr Arg Val Arg Ser Ser Thr Ser Pro Thr Thr Asn Val Leu Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 
                85                  90                  95      


Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 
            100                 105                 110         


Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 
        115                 120                 125             


Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe 
    130                 135                 140                 


Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys 
145                 150                 155                 160 


Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp 
                165                 170                 175     


Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu 
            180                 185                 190         


Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 
        195                 200                 205             


Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 
    210                 215                 220                 


Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 
225                 230                 235                 240 


Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp 
                245                 250                 255     


Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met 
            260                 265                 270         


Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu 
        275                 280                 285             


Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu 
    290                 295                 300                 


Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser 
305                 310                 315                 320 


Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 
                325                 330                 335     


Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 
            340                 345                 350         


Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 
        355                 360                 365             


Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe 
    370                 375                 380                 


Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp 
385                 390                 395                 400 


Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg 
                405                 410                 415     


Gly Pro 
        


<210>  91
<211>  2490
<212>  DNA
<213>  Homo sapiens

<400>  91
ggcgcagcgg ctccctataa gcagaggagc tgtccgtgtg ctgaaacggc ccgagaagct       60

cgcccggaga acggggagga atatgctgtg gagctcctct gccatataaa caaaaagagg      120

aaatctttca aacatggctg aagcaaagac ccactggctt ggagcagccc tgtctcttat      180

ccctttaatt ttcctcatct ctggggctga agcagcttca tttcagagaa accagctgct      240

tcagaaagaa ccagacctca ggttggaaaa tgtccaaaag tttcccagtc ctgaaatgat      300

cagggctttg gagtacatag aaaacctccg acaacaagct cataaggaag aaagcagccc      360

agattataat ccctaccaag gtgtctctgt cccccttcag caaaaagaaa atggcgatga      420

aagccacttg cccgagaggg attcactgag tgaagaagac tggatgagaa taatactcga      480

agctttgaga caggctgaaa atgagcctca gtctgcacca aaagaaaata agccctatgc      540

cttgaattca gaaaagaact ttccaatgga catgagtgat gattatgaga cacagcagtg      600

gccagaaaga aagcttaagc acatgcaatt ccctcctatg tatgaagaga attccaggga      660

taaccccttt aaacgcacaa atgaaatagt ggaggaacaa tatactcctc aaagccttgc      720

tacattggaa tctgtcttcc aagagctggg gaaactgaca ggaccaaaca accagaaacg      780

tgagaggatg gatgaggagc aaaaacttta tacggatgat gaagatgata tctacaaggc      840

taataacatt gcctatgaag atgtggtcgg gggagaagac tggaacccag tagaggagaa      900

aatagagagt caaacccagg aagaggtgag agacagcaaa gagaatatag aaaaaaatga      960

acaaatcaac gatgagatga aacgctcagg gcagcttggc atccaggaag aagatcttcg     1020

gaaagagagt aaagaccaac tctcagatga tgtctccaaa gtaattgcct atttgaaaag     1080

gttagtaaat gctgcaggaa gtgggaggtt acagaatggg caaaatgggg aaagggccac     1140

caggcttttt gagaaacctc ttgattctca gtctatttat cagctgattg aaatctcaag     1200

gaatttacag atacccccag aagacttaat tgagatgctc aaaactgggg agaagccgaa     1260

tggatcagtg gaaccggagc gggagcttga ccttcctgtt gacctagatg acatctcaga     1320

ggctgactta gaccatccag acctgttcca aaataggatg ctctccaaga gtggctaccc     1380

taaaacacct ggtcgtgctg ggactgaggc cctaccagac gggctcagtg ttgaggatat     1440

tttaaatctt ttagggatgg agagtgcagc aaatcagaaa acgtcgtatt ttcccaatcc     1500

atataaccag gagaaagttc tgccaaggct cccttatggt gctggaagat ctagatcgaa     1560

ccagcttccc aaagctgcct ggattccaca tgttgaaaac agacagatgg catatgaaaa     1620

cctgaacgac aaggatcaag aattaggtga gtacttggcc aggatgctag ttaaataccc     1680

tgagatcatt aattcaaacc aagtgaagcg agttcctggt caaggctcat ctgaagatga     1740

cctgcaggaa gaggaacaaa ttgagcaggc catcaaagag catttgaatc aaggcagctc     1800

tcaggagact gacaagctgg ccccggtgag caaaaggttc cctgtggggc ccccgaagaa     1860

tgatgatacc ccaaataggc agtactggga tgaagatctg ttaatgaaag tgctggaata     1920

cctcaaccaa gaaaaggcag aaaagggaag ggagcatatt gctaagagag caatggaaaa     1980

tatgtaagct gctttcatta attaccctac tttcattcct cccaccccaa gcaaatccca     2040

acatttctct tcagtgtgtt gacttctatc ctgttaacac tgtaatatct ttaaatgatg     2100

tacaggcaga tgaaaccagg tcactgggga gtctgcttca tttcctctga gctgttatct     2160

tgtgtatgga tatgtgtaaa tgttatgact ccttgataaa aaatttatta tgtccattat     2220

tcaagaaaga tatctatgac tgtgtttaat agtatatcta atggctgtgg cattgttgat     2280

gctcacatat gataaaaaag tgtcctataa ttctattgaa agtttttaat atttattgaa     2340

ttattttgtt actgtctgta gtgttttgtg gagtactgga ccaaaaaaat aaagcattat     2400

aaatatatag ttttatttat aaggcctttt ctattgtgtg ttttactgtt gattaataaa     2460

tgttatttct ggacaaaaaa aaaaaaaaaa                                      2490


<210>  92
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ala Glu Ala Lys Thr His Trp Leu Gly Ala Ala Leu Ser Leu Ile 
1               5                   10                  15      


Pro Leu Ile Phe Leu Ile Ser Gly Ala Glu Ala Ala Ser Phe Gln Arg 
            20                  25                  30          


Asn Gln Leu Leu Gln Lys Glu Pro Asp Leu Arg Leu Glu Asn Val Gln 
        35                  40                  45              


Lys Phe Pro Ser Pro Glu Met Ile Arg Ala Leu Glu Tyr Ile Glu Asn 
    50                  55                  60                  


Leu Arg Gln Gln Ala His Lys Glu Glu Ser Ser Pro Asp Tyr Asn Pro 
65                  70                  75                  80  


Tyr Gln Gly Val Ser Val Pro Leu Gln Gln Lys Glu Asn Gly Asp Glu 
                85                  90                  95      


Ser His Leu Pro Glu Arg Asp Ser Leu Ser Glu Glu Asp Trp Met Arg 
            100                 105                 110         


Ile Ile Leu Glu Ala Leu Arg Gln Ala Glu Asn Glu Pro Gln Ser Ala 
        115                 120                 125             


Pro Lys Glu Asn Lys Pro Tyr Ala Leu Asn Ser Glu Lys Asn Phe Pro 
    130                 135                 140                 


Met Asp Met Ser Asp Asp Tyr Glu Thr Gln Gln Trp Pro Glu Arg Lys 
145                 150                 155                 160 


Leu Lys His Met Gln Phe Pro Pro Met Tyr Glu Glu Asn Ser Arg Asp 
                165                 170                 175     


Asn Pro Phe Lys Arg Thr Asn Glu Ile Val Glu Glu Gln Tyr Thr Pro 
            180                 185                 190         


Gln Ser Leu Ala Thr Leu Glu Ser Val Phe Gln Glu Leu Gly Lys Leu 
        195                 200                 205             


Thr Gly Pro Asn Asn Gln Lys Arg Glu Arg Met Asp Glu Glu Gln Lys 
    210                 215                 220                 


Leu Tyr Thr Asp Asp Glu Asp Asp Ile Tyr Lys Ala Asn Asn Ile Ala 
225                 230                 235                 240 


Tyr Glu Asp Val Val Gly Gly Glu Asp Trp Asn Pro Val Glu Glu Lys 
                245                 250                 255     


Ile Glu Ser Gln Thr Gln Glu Glu Val Arg Asp Ser Lys Glu Asn Ile 
            260                 265                 270         


Glu Lys Asn Glu Gln Ile Asn Asp Glu Met Lys Arg Ser Gly Gln Leu 
        275                 280                 285             


Gly Ile Gln Glu Glu Asp Leu Arg Lys Glu Ser Lys Asp Gln Leu Ser 
    290                 295                 300                 


Asp Asp Val Ser Lys Val Ile Ala Tyr Leu Lys Arg Leu Val Asn Ala 
305                 310                 315                 320 


Ala Gly Ser Gly Arg Leu Gln Asn Gly Gln Asn Gly Glu Arg Ala Thr 
                325                 330                 335     


Arg Leu Phe Glu Lys Pro Leu Asp Ser Gln Ser Ile Tyr Gln Leu Ile 
            340                 345                 350         


Glu Ile Ser Arg Asn Leu Gln Ile Pro Pro Glu Asp Leu Ile Glu Met 
        355                 360                 365             


Leu Lys Thr Gly Glu Lys Pro Asn Gly Ser Val Glu Pro Glu Arg Glu 
    370                 375                 380                 


Leu Asp Leu Pro Val Asp Leu Asp Asp Ile Ser Glu Ala Asp Leu Asp 
385                 390                 395                 400 


His Pro Asp Leu Phe Gln Asn Arg Met Leu Ser Lys Ser Gly Tyr Pro 
                405                 410                 415     


Lys Thr Pro Gly Arg Ala Gly Thr Glu Ala Leu Pro Asp Gly Leu Ser 
            420                 425                 430         


Val Glu Asp Ile Leu Asn Leu Leu Gly Met Glu Ser Ala Ala Asn Gln 
        435                 440                 445             


Lys Thr Ser Tyr Phe Pro Asn Pro Tyr Asn Gln Glu Lys Val Leu Pro 
    450                 455                 460                 


Arg Leu Pro Tyr Gly Ala Gly Arg Ser Arg Ser Asn Gln Leu Pro Lys 
465                 470                 475                 480 


Ala Ala Trp Ile Pro His Val Glu Asn Arg Gln Met Ala Tyr Glu Asn 
                485                 490                 495     


Leu Asn Asp Lys Asp Gln Glu Leu Gly Glu Tyr Leu Ala Arg Met Leu 
            500                 505                 510         


Val Lys Tyr Pro Glu Ile Ile Asn Ser Asn Gln Val Lys Arg Val Pro 
        515                 520                 525             


Gly Gln Gly Ser Ser Glu Asp Asp Leu Gln Glu Glu Glu Gln Ile Glu 
    530                 535                 540                 


Gln Ala Ile Lys Glu His Leu Asn Gln Gly Ser Ser Gln Glu Thr Asp 
545                 550                 555                 560 


Lys Leu Ala Pro Val Ser Lys Arg Phe Pro Val Gly Pro Pro Lys Asn 
                565                 570                 575     


Asp Asp Thr Pro Asn Arg Gln Tyr Trp Asp Glu Asp Leu Leu Met Lys 
            580                 585                 590         


Val Leu Glu Tyr Leu Asn Gln Glu Lys Ala Glu Lys Gly Arg Glu His 
        595                 600                 605             


Ile Ala Lys Arg Ala Met Glu Asn Met 
    610                 615         


<210>  93
<211>  716
<212>  DNA
<213>  Homo sapiens

<400>  93
aggctcagta taaatagcag ccaccgctcc ctggcaggca gggacccgca gctcagctac       60

agcacagatc aggtgaggag cacaccaagg agtgattttt aaaacttact ctgttttctc      120

tttcccaaca agattatcat ttcctttaaa aaaaatagtt atcctggggc atacagccat      180

accattctga aggtgtctta tctcctctga tctagagagc accatgaagc ttctcacggg      240

cctggttttc tgctccttgg tcctgggtgt cagcagccga agcttctttt cgttccttgg      300

cgaggctttt gatggggctc gggacatgtg gagagcctac tctgacatga gagaagccaa      360

ttacatcggc tcagacaaat acttccatgc tcgggggaac tatgatgctg ccaaaagggg      420

acctgggggt gcctgggctg cagaagtgat cagcgatgcc agagagaata tccagagatt      480

ctttggccat ggtgcggagg actcgctggc tgatcaggct gccaatgaat ggggcaggag      540

tggcaaagac cccaatcact tccgacctgc tggcctgcct gagaaatact gagcttcctc      600

ttcactctgc tctcaggaga tctggctgtg aggccctcag ggcagggata caaagcgggg      660

agagggtaca caatgggtat ctaataaata cttaagaggt ggaatttgtg gaaact          716


<210>  94
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  95
<211>  1651
<212>  DNA
<213>  Homo sapiens

<400>  95
gacctagaga ggtcccagga cacgccactg tcccgccttc cccattgccc gccccactgg       60

ccagtcccca cgcccacaca cccaaggctg ccccatctgg cgctgattat cctgctgctg      120

ccgccaccgc tgctgctgct ctgcaaaatt cagctgctgc ctctgtcttg aggaccccag      180

cgcctttccc ccggggccat gctgcctgca gccacagcct ccctcctggg gcccctcctc      240

actgcctgcg ccctgctgcc ttttgcccag ggccagaccc ccaactacac cagacccgtg      300

ttcctgtgcg gaggggatgt gaagggggaa tcaggttacg tggcaagtga ggggttcccc      360

aacctctacc cccctaataa ggagtgcatc tggaccataa cggtccccga gggccagact      420

gtgtccctct cattccgagt cttcgacctg gagctgcacc ccgcctgccg ctacgatgct      480

ctggaggtct tcgctgggtc tgggacttcc ggccagcggc tcggacgctt ttgtgggacc      540

ttccggcctg cgcccctagt cgcccccggc aaccaggtga ccctgaggat gacgacggat      600

gagggcacag gaggacgagg cttcctgctc tggtacagcg ggcgggccac ctcgggcact      660

gagcaccaat tttgcggggg gcggctggag aaggcccagg gaaccctgac cacgcccaac      720

tggcccgagt ccgattaccc cccgggcatc agctgttcct ggcacatcat cgcgcccccg      780

gaccaggtca tcgcgctgac cttcgagaag tttgacctgg agccggacac ctactgccgc      840

tatgactcgg tcagcgtgtt caacggagcc gtgagcgacg actcccggag gctggggaag      900

ttctgcggcg acgcagtccc gggctccatc tcctccgaag ggaatgaact cctcgtccag      960

ttcgtctcag atctcagtgt caccgctgat ggcttctcag cctcctacaa gaccctgccg     1020

cggggcactg ccaaagaagg gcaagggccc ggccccaaac ggggaactga gcctaaagtc     1080

aagctgcccc ccaagtccca acctccggag aaaacagagg aatctccttc agcccctgat     1140

gcacccacct gcccaaagca gtgccgccgg acaggcacct tgcagagcaa cttctgtgcc     1200

agcagccttg tggtgactgc gacagtgaag tccatggttc gggagccagg ggagggcctt     1260

gccgtgactg tcagtcttat tggtgcttat aaaactggag gactggacct gccttctcca     1320

cccactggtg cctccctgaa gttttacgtg ccttgcaagc agtgcccccc catgaagaaa     1380

ggagtcagtt atctgctgat gggccaggta gaagagaaca gaggccccgt ccttcctcca     1440

gagagctttg tggttctcca ccggcccaac caggaccaga tcctcaccaa cctaagcaag     1500

aggaagtgcc cctctcaacc tgtgcgggct gctgcgtccc aggactgaga cgcaggccag     1560

ccccggcccc tagccctcag gccttctttc ttatccaaat aaatgtttct taatgaggaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                    1651


<210>  96
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Leu Pro Ala Ala Thr Ala Ser Leu Leu Gly Pro Leu Leu Thr Ala 
1               5                   10                  15      


Cys Ala Leu Leu Pro Phe Ala Gln Gly Gln Thr Pro Asn Tyr Thr Arg 
            20                  25                  30          


Pro Val Phe Leu Cys Gly Gly Asp Val Lys Gly Glu Ser Gly Tyr Val 
        35                  40                  45              


Ala Ser Glu Gly Phe Pro Asn Leu Tyr Pro Pro Asn Lys Glu Cys Ile 
    50                  55                  60                  


Trp Thr Ile Thr Val Pro Glu Gly Gln Thr Val Ser Leu Ser Phe Arg 
65                  70                  75                  80  


Val Phe Asp Leu Glu Leu His Pro Ala Cys Arg Tyr Asp Ala Leu Glu 
                85                  90                  95      


Val Phe Ala Gly Ser Gly Thr Ser Gly Gln Arg Leu Gly Arg Phe Cys 
            100                 105                 110         


Gly Thr Phe Arg Pro Ala Pro Leu Val Ala Pro Gly Asn Gln Val Thr 
        115                 120                 125             


Leu Arg Met Thr Thr Asp Glu Gly Thr Gly Gly Arg Gly Phe Leu Leu 
    130                 135                 140                 


Trp Tyr Ser Gly Arg Ala Thr Ser Gly Thr Glu His Gln Phe Cys Gly 
145                 150                 155                 160 


Gly Arg Leu Glu Lys Ala Gln Gly Thr Leu Thr Thr Pro Asn Trp Pro 
                165                 170                 175     


Glu Ser Asp Tyr Pro Pro Gly Ile Ser Cys Ser Trp His Ile Ile Ala 
            180                 185                 190         


Pro Pro Asp Gln Val Ile Ala Leu Thr Phe Glu Lys Phe Asp Leu Glu 
        195                 200                 205             


Pro Asp Thr Tyr Cys Arg Tyr Asp Ser Val Ser Val Phe Asn Gly Ala 
    210                 215                 220                 


Val Ser Asp Asp Ser Arg Arg Leu Gly Lys Phe Cys Gly Asp Ala Val 
225                 230                 235                 240 


Pro Gly Ser Ile Ser Ser Glu Gly Asn Glu Leu Leu Val Gln Phe Val 
                245                 250                 255     


Ser Asp Leu Ser Val Thr Ala Asp Gly Phe Ser Ala Ser Tyr Lys Thr 
            260                 265                 270         


Leu Pro Arg Gly Thr Ala Lys Glu Gly Gln Gly Pro Gly Pro Lys Arg 
        275                 280                 285             


Gly Thr Glu Pro Lys Val Lys Leu Pro Pro Lys Ser Gln Pro Pro Glu 
    290                 295                 300                 


Lys Thr Glu Glu Ser Pro Ser Ala Pro Asp Ala Pro Thr Cys Pro Lys 
305                 310                 315                 320 


Gln Cys Arg Arg Thr Gly Thr Leu Gln Ser Asn Phe Cys Ala Ser Ser 
                325                 330                 335     


Leu Val Val Thr Ala Thr Val Lys Ser Met Val Arg Glu Pro Gly Glu 
            340                 345                 350         


Gly Leu Ala Val Thr Val Ser Leu Ile Gly Ala Tyr Lys Thr Gly Gly 
        355                 360                 365             


Leu Asp Leu Pro Ser Pro Pro Thr Gly Ala Ser Leu Lys Phe Tyr Val 
    370                 375                 380                 


Pro Cys Lys Gln Cys Pro Pro Met Lys Lys Gly Val Ser Tyr Leu Leu 
385                 390                 395                 400 


Met Gly Gln Val Glu Glu Asn Arg Gly Pro Val Leu Pro Pro Glu Ser 
                405                 410                 415     


Phe Val Val Leu His Arg Pro Asn Gln Asp Gln Ile Leu Thr Asn Leu 
            420                 425                 430         


Ser Lys Arg Lys Cys Pro Ser Gln Pro Val Arg Ala Ala Ala Ser Gln 
        435                 440                 445             


Asp 
    


<210>  97
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  97
aagcttccac catgcacagc tttcctccac tg                                     32


<210>  98
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer2

<400>  98
ggccggcctc aatttttcct gcagttga                                          28


