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<110>  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)
       Universit Claude Bernard Lyon 1
 
<120>  C-CBL AND ANTAGONISTS THEREOF FOR THE TREATMENT AND DIAGNOSIS OF 
       CANCER

<130>  BET 09P1823

<150>  US 12/369309
<151>  2009-02-11

<160>  7     

<170>  PatentIn version 3.4

<210>  1
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Thr Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala 
            20                  25                  30          


Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro 
        35                  40                  45              


Gly Thr Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp 
    50                  55                  60                  


Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser 
65                  70                  75                  80  


Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg 
                85                  90                  95      


Thr Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn 
            100                 105                 110         


Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln 
        115                 120                 125             


Thr Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn 
    130                 135                 140                 


Ser Gln Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His 
145                 150                 155                 160 


Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly 
                165                 170                 175     


Asp Thr Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys 
            180                 185                 190         


Ala Phe Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala 
        195                 200                 205             


Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu 
    210                 215                 220                 


Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu 
225                 230                 235                 240 


Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg 
                245                 250                 255     


Asn Trp Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu 
            260                 265                 270         


Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro 
        275                 280                 285             


Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala 
    290                 295                 300                 


Ile Gly Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His 
305                 310                 315                 320 


Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe 
                325                 330                 335     


Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu 
            340                 345                 350         


Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr 
        355                 360                 365             


Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys 
    370                 375                 380                 


Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met 
385                 390                 395                 400 


Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys 
                405                 410                 415     


Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp 
            420                 425                 430         


Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu 
        435                 440                 445             


Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp 
    450                 455                 460                 


Asp Thr Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg 
465                 470                 475                 480 


Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val 
                485                 490                 495     


Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser 
            500                 505                 510         


Ala Ser Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His 
        515                 520                 525             


Lys Asp Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro 
    530                 535                 540                 


Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro 
545                 550                 555                 560 


Gln Arg Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp 
                565                 570                 575     


Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro 
            580                 585                 590         


Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro 
        595                 600                 605             


Trp Thr Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu 
    610                 615                 620                 


Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr 
625                 630                 635                 640 


Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly 
                645                 650                 655     


Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala 
            660                 665                 670         


Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro 
        675                 680                 685             


Gly Glu Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser 
    690                 695                 700                 


Ser Arg Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys 
705                 710                 715                 720 


Asp Cys Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn 
                725                 730                 735     


Ile Gln Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu 
            740                 745                 750         


Gly Asn Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu 
        755                 760                 765             


Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val 
    770                 775                 780                 


Leu Ala Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe 
785                 790                 795                 800 


Gly Trp Leu Ser Leu Asp Gly Asp Pro Thr Thr Asn Val Thr Glu Gly 
                805                 810                 815     


Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn 
            820                 825                 830         


Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala 
        835                 840                 845             


Ser Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu 
    850                 855                 860                 


Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile 
865                 870                 875                 880 


Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val 
                885                 890                 895     


Ser Ile Ser Ser Pro Ala His Val Ala Thr 
            900                 905     


<210>  2
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  iRNA

<400>  2
gggaaggcuu cuauuuguu                                                  19


<210>  3
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  iRNA

<400>  3
cuguccaucu agagacaaa                                                  19


<210>  4
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  RT-PCR primer

<400>  4
aaaaagggga aagaggagtg cgcttgtcaa                                      30


<210>  5
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  RT-PCR primer

<400>  5
attatatgtc ttttggcctc ctctctactg                                      30

<210>  6
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  6
atggacaagg ttggtgcggt tgtggt                                          26


<210>  7
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  7
gaagaggctg atagtctgct tagt                                            24