
                                SEQUENCE LISTING

<110> Volker Heinrichs

<120> Variant Axmi-R1 Delta-Endotoxin Genes
  and Methods for Their Use
  

<130> 45600/384850

<150> 61/229,567          
<151> 2009-07-29  

<150> 61/150,309          
<151> 2009-02-05  

<160> 64

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1935
<212> DNA
<213> Bacillus thuringiensis

<400> 1
atgaatccga acaatcgaag tgaacatgat acaataaaaa ctactgaaaa taatgaggtg 60
ccaactaacc atgttcaata tcctttagcg gaaactccaa atccaacact agaagattta 120
aattataaag agtttttaag aatgactgca gataataata cggaagcact agatagctct 180
acaacaaaag atgtcattca aaaaggcatt tccgtagtag gtgatctcct aggcgtagta 240
ggtttcccgt ttggtggagc gcttgtttcg ttttatacaa actttttaaa tactatttgg 300
ccaagtgaag acccgtggaa ggcttttatg gaacaagtag aagcattgat ggatcagaaa 360
atagctgatt atgcaaaaaa taaagctctt gcagagttac agggccttca aaataatgtc 420
gaagattatg tgagtgcatt gagttcatgg caaaaaaatc ctgtgagttc acgaaatcca 480
catagccagg ggcggataag agagctgttt tctcaagcag aaagtcattt tcgtaattca 540
atgccttcgt ttgcaatttc tggatacgag gttctatttc taacaacata tgcacaagct 600
gccaacacac atttattttt actaaaagac gctcaaattt atggagaaga atggggatac 660
gaaaaagaag atattgctga attttataaa agacaactaa aacttacgca agaatatact 720
gaccattgtg tcaaatggta taatgttgga ttagataaat taagaggttc atcttatgaa 780
tcttgggtaa actttaaccg ttatcgcaga gagatgacat taacagtatt agatttaatt 840
gcactatttc cattgtatga tgttcggcta tacccaaaag aagttaaaac cgaattaaca 900
agagacgttt taacagatcc aattgtcgga gtcaacaacc ttaggggcta tggaacaacc 960
ttctctaata tagaaaatta tattcgaaaa ccacatctat ttgactatct gcatagaatt 1020
caatttcaca cgcggttcca accaggatat tatggaaatg actctttcaa ttattggtcc 1080
ggtaattatg tttcaactag accaagcata ggatcaaatg atataatcac atctccattc 1140
tatggaaata aatccagtga acctgtacaa aatttagaat ttaatggaga aaaagtctat 1200
agagccgtag caaatacaaa tcttgcggtc tggccgtccg ctgtatattc aggtgttaca 1260
aaagtggaat ttagccaata taatgatcaa acagatgaag caagtacaca aacgtacgac 1320
tcaaaaagaa atgttggcgc ggtcagctgg gattctatcg atcaattgcc tccagaaaca 1380
acagatgaac ctctagaaaa gggatatagc catcaactca attatgtaat gtgcttttta 1440
atgcagggta gtagaggaac aatcccagtg ttaacttgga cacataaaag tgtagacttt 1500
tttaacatga ttgattcgaa aaaaattaca caacttccgt tagtaaaggc atataagtta 1560
caatctggtg cttccgttgt cgcaggtcct aggtttacag gaggagatat cattcaatgc 1620
acagaaaatg gaagtgcggc aactatttac gttacaccgg atgtgtcgta ctctcaaaaa 1680
tatcgagcta gaattcatta tgcttctaca tctcagataa catttacact cagtttagac 1740
ggggcaccat ttaatcaata ctatttcgat aaaacgataa ataaaggaga cacattaacg 1800
tataattcat ttaatttagc aagtttcagc acaccattcg aattatcagg gaataactta 1860
caaataggcg tcacaggatt aagtgctgga gataaagttt atatagacaa aattgaattt 1920
attccagtga attag                                                  1935

<210> 2
<211> 644
<212> PRT
<213> Bacillus thuringiensis

<400> 2
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 3
<211> 1965
<212> DNA
<213> Artificial Sequence

<220> 
<223> axmi-R1 with histidine tag

<400> 3
atggcacatc accaccacca tcacggatcc atgaatccga acaatcgaag tgaacatgat 60
acaataaaaa ctactgaaaa taatgaggtg ccaactaacc atgttcaata tcctttagcg 120
gaaactccaa atccaacact agaagattta aattataaag agtttttaag aatgactgca 180
gataataata cggaagcact agatagctct acaacaaaag atgtcattca aaaaggcatt 240
tccgtagtag gtgatctcct aggcgtagta ggtttcccgt ttggtggagc gcttgtttcg 300
ttttatacaa actttttaaa tactatttgg ccaagtgaag acccgtggaa ggcttttatg 360
gaacaagtag aagcattgat ggatcagaaa atagctgatt atgcaaaaaa taaagctctt 420
gcagagttac agggccttca aaataatgtc gaagattatg tgagtgcatt gagttcatgg 480
caaaaaaatc ctgtgagttc acgaaatcca catagccagg ggcggataag agagctgttt 540
tctcaagcag aaagtcattt tcgtaattca atgccttcgt ttgcaatttc tggatacgag 600
gttctatttc taacaacata tgcacaagct gccaacacac atttattttt actaaaagac 660
gctcaaattt atggagaaga atggggatac gaaaaagaag atattgctga attttataaa 720
agacaactaa aacttacgca agaatatact gaccattgtg tcaaatggta taatgttgga 780
ttagataaat taagaggttc atcttatgaa tcttgggtaa actttaaccg ttatcgcaga 840
gagatgacat taacagtatt agatttaatt gcactatttc cattgtatga tgttcggcta 900
tacccaaaag aagttaaaac cgaattaaca agagacgttt taacagatcc aattgtcgga 960
gtcaacaacc ttaggggcta tggaacaacc ttctctaata tagaaaatta tattcgaaaa 1020
ccacatctat ttgactatct gcatagaatt caatttcaca cgcggttcca accaggatat 1080
tatggaaatg actctttcaa ttattggtcc ggtaattatg tttcaactag accaagcata 1140
ggatcaaatg atataatcac atctccattc tatggaaata aatccagtga acctgtacaa 1200
aatttagaat ttaatggaga aaaagtctat agagccgtag caaatacaaa tcttgcggtc 1260
tggccgtccg ctgtatattc aggtgttaca aaagtggaat ttagccaata taatgatcaa 1320
acagatgaag caagtacaca aacgtacgac tcaaaaagaa atgttggcgc ggtcagctgg 1380
gattctatcg atcaattgcc tccagaaaca acagatgaac ctctagaaaa gggatatagc 1440
catcaactca attatgtaat gtgcttttta atgcagggta gtagaggaac aatcccagtg 1500
ttaacttgga cacataaaag tgtagacttt tttaacatga ttgattcgaa aaaaattaca 1560
caacttccgt tagtaaaggc atataagtta caatctggtg cttccgttgt cgcaggtcct 1620
aggtttacag gaggagatat cattcaatgc acagaaaatg gaagtgcggc aactatttac 1680
gttacaccgg atgtgtcgta ctctcaaaaa tatcgagcta gaattcatta tgcttctaca 1740
tctcagataa catttacact cagtttagac ggggcaccat ttaatcaata ctatttcgat 1800
aaaacgataa ataaaggaga cacattaacg tataattcat ttaatttagc aagtttcagc 1860
acaccattcg aattatcagg gaataactta caaataggcg tcacaggatt aagtgctgga 1920
gataaagttt atatagacaa aattgaattt attccagtga attag                 1965

<210> 4
<211> 654
<212> PRT
<213> Artificial Sequence

<220> 
<223> Axmi-R1 with histidine tag

<400> 4
Met Ala His His His His His His Gly Ser Met Asn Pro Asn Asn Arg
 1               5                  10                  15      
Ser Glu His Asp Thr Ile Lys Thr Thr Glu Asn Asn Glu Val Pro Thr
            20                  25                  30          
Asn His Val Gln Tyr Pro Leu Ala Glu Thr Pro Asn Pro Thr Leu Glu
        35                  40                  45              
Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met Thr Ala Asp Asn Asn Thr
    50                  55                  60                  
Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp Val Ile Gln Lys Gly Ile
65                  70                  75                  80  
Ser Val Val Gly Asp Leu Leu Gly Val Val Gly Phe Pro Phe Gly Gly
                85                  90                  95      
Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu Asn Thr Ile Trp Pro Ser
            100                 105                 110         
Glu Asp Pro Trp Lys Ala Phe Met Glu Gln Val Glu Ala Leu Met Asp
        115                 120                 125             
Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys Ala Leu Ala Glu Leu Gln
    130                 135                 140                 
Gly Leu Gln Asn Asn Val Glu Asp Tyr Val Ser Ala Leu Ser Ser Trp
145                 150                 155                 160 
Gln Lys Asn Pro Val Ser Ser Arg Asn Pro His Ser Gln Gly Arg Ile
                165                 170                 175     
Arg Glu Leu Phe Ser Gln Ala Glu Ser His Phe Arg Asn Ser Met Pro
            180                 185                 190         
Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu Phe Leu Thr Thr Tyr Ala
        195                 200                 205             
Gln Ala Ala Asn Thr His Leu Phe Leu Leu Lys Asp Ala Gln Ile Tyr
    210                 215                 220                 
Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp Ile Ala Glu Phe Tyr Lys
225                 230                 235                 240 
Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr Asp His Cys Val Lys Trp
                245                 250                 255     
Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly Ser Ser Tyr Glu Ser Trp
            260                 265                 270         
Val Asn Phe Asn Arg Tyr Arg Arg Glu Met Thr Leu Thr Val Leu Asp
        275                 280                 285             
Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val Arg Leu Tyr Pro Lys Glu
    290                 295                 300                 
Val Lys Thr Glu Leu Thr Arg Asp Val Leu Thr Asp Pro Ile Val Gly
305                 310                 315                 320 
Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr Phe Ser Asn Ile Glu Asn
                325                 330                 335     
Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr Leu His Arg Ile Gln Phe
            340                 345                 350         
His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly Asn Asp Ser Phe Asn Tyr
        355                 360                 365             
Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro Ser Ile Gly Ser Asn Asp
    370                 375                 380                 
Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys Ser Ser Glu Pro Val Gln
385                 390                 395                 400 
Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr Arg Ala Val Ala Asn Thr
                405                 410                 415     
Asn Leu Ala Val Trp Pro Ser Ala Val Tyr Ser Gly Val Thr Lys Val
            420                 425                 430         
Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp Glu Ala Ser Thr Gln Thr
        435                 440                 445             
Tyr Asp Ser Lys Arg Asn Val Gly Ala Val Ser Trp Asp Ser Ile Asp
    450                 455                 460                 
Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro Leu Glu Lys Gly Tyr Ser
465                 470                 475                 480 
His Gln Leu Asn Tyr Val Met Cys Phe Leu Met Gln Gly Ser Arg Gly
                485                 490                 495     
Thr Ile Pro Val Leu Thr Trp Thr His Lys Ser Val Asp Phe Phe Asn
            500                 505                 510         
Met Ile Asp Ser Lys Lys Ile Thr Gln Leu Pro Leu Val Lys Ala Tyr
        515                 520                 525             
Lys Leu Gln Ser Gly Ala Ser Val Val Ala Gly Pro Arg Phe Thr Gly
    530                 535                 540                 
Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly Ser Ala Ala Thr Ile Tyr
545                 550                 555                 560 
Val Thr Pro Asp Val Ser Tyr Ser Gln Lys Tyr Arg Ala Arg Ile His
                565                 570                 575     
Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr Leu Ser Leu Asp Gly Ala
            580                 585                 590         
Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr Ile Asn Lys Gly Asp Thr
        595                 600                 605             
Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser Phe Ser Thr Pro Phe Glu
    610                 615                 620                 
Leu Ser Gly Asn Asn Leu Gln Ile Gly Val Thr Gly Leu Ser Ala Gly
625                 630                 635                 640 
Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Asn
                645                 650                 


<210> 5
<211> 1935
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic nucleotide sequence encoding
      AXMI-R1(evo18)

<400> 5
atgaacccca acaacaggag cgagcatgac accatcaaga caacagagaa caatgaagtt 60
ccaacaaacc atgttcaata tcctcttgct gaaacaccaa atccaacctt ggaggacctc 120
aactacaagg agttcttgag gatgacagct gacaacaaca cagaagctct ggattcaagc 180
accaccaagg atgtcatcca gaagggcatc tctgttgttg gagatctgct gggcgtggtg 240
ggcttcccct tcggcggcgc gctggtgagc ttctacacca acttcctcaa caccatctgg 300
ccatcagaag atccatggaa ggccttcatg gagcaagtgg aggcgctgat ggaccagaag 360
attgctgatt atgccaagaa caaggcgctg gcggagctgc aaggcctcca gaacaatgtg 420
gaggattatg tttctgctct gagcagctgg cagaagaacc ctgtttcttc aagaaatcct 480
cacagccaag gaaggatcag ggagctcttc tcccaagcag aaagccactt cagaaacagc 540
atgccctcct tcgccatctc aggatatgag gtgctcttcc tcaccacata tgctcaagct 600
gccaacaccc acctcttcct gctgaaggat gctcaaattt atggagaaga atggggatat 660
gagaaggagg acattgctga gttctacaag aggcagctaa agctcaccca ggagtacaca 720
gatcactgcg tcaaatggta caatgttggg ctggacaagc tccgcggcag cagctatgaa 780
agctgggtga acttcaacag atacaggagg gagatgaccc tcaccgtgct ggacctcatt 840
gctctcttcc ctctctatga tgtccgcctc taccccaagg aggtgaaaac agagctaaca 900
agagatgtgc tgacagatcc catcgtcggc gtcaacaact tgaggacata tggcaccacc 960
ttcagcaaca tcgagaacta catcaggaag cctcatctct tcgactacct ccacaggatt 1020
cagttccaca caaggttcca gcctggatat tatggaaatg acagcttcaa ctactggagc 1080
ggcaactatg tttcaacaag gccaagcatt ggaagcaatg acatcataac ttctcccttc 1140
tatggcaaca agagcagcga gcctgttcag aacctggagt tcaatggaga gaaggtgtac 1200
cgcgccgtcg ccaacaccaa cctcgccgtc tggccatcag ctgtctacag cggcgtgacc 1260
aaggtggagt tcagccagta caatgatcaa acagatgaag caagcaccca aacatatgac 1320
agcaagagaa atgttggagc tgtttcatgg gacagcatcg accagctgcc gccggagaca 1380
acagatgagc cgctggagaa gggctacagc caccagctca actatgtgat gtgcttcttg 1440
atgcaaggaa gcagaggcac catccccgtg ctgacatgga cccacaaatc agtggacttc 1500
ttcaacatga ttgacagcaa gaagatcacc cagctgccgc tggtgaaggc ctacaagctg 1560
caaagcggcg cctccgtggt ggctgggccg cgcttcactg gaggagacat catccaatgc 1620
acagaaaatg gcagcgccgc caccatctat gtcacccctg atgtcagcta cagccagaag 1680
tacagagcaa ggattcatta tgcttcaaca agccagatca ccttcacctt gagcttggat 1740
ggagctccct tcaaccagta ctacttcgac aagaccatca acaaaggaga caccctcacc 1800
tacaacagct tcaacctcgc ctccttctcc acgccatttg agctctcagg aaacaacctc 1860
cagatcggcg tcaccggcct ctccgccggc gacaaggtgt acatcgacaa gatcgagttc 1920
atccccgtca actaa                                                  1935

<210> 6
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> Axmi-R1 variant sequence (AXMI-R1(evo18))

<400> 6
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Thr Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 7
<211> 1935
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic nucleotide sequence encoding AXMI-R1
      variant sequence (AXMI-R1(evo19))

<400> 7
atgaacccca acaacaggag cgagcatgac accatcaaga caacagagaa caatgaagtt 60
ccaacaaatc atgtgcagta cccgctggcg gagacaccaa atccaacatt ggaggacctc 120
aactacaagg agttcttgag gatgacggcg gacaacaaca cagaagctct ggacagcagc 180
accaccaagg atgtcatcca gaagggcatc tcagtggtgg gagatcttct tggagtggtg 240
ggcttcccct tcggcggcgc gctggttagc ttctacacca acttcctcaa caccatctgg 300
ccatcagaag atccatggaa ggccttcatg gagcaagtgg aggcgctgat ggaccagaag 360
atcgccgact acgccaagaa caaggcgctg gcggagctgc aaggcctcca gaacaatgtt 420
gaagattatg tctcggcgct gagcagctgg cagaagaacc cggtgagctc aagaaatatc 480
cattctcaag gaaggatcag ggagctcttc agccaagcag aaagccactt cagaaacagc 540
atgccgagct tcgccatctc aggatatgag gtgctcttcc tcaccaccta tgctcaagct 600
gccaacaccc acctcttcct gctgaaggat gctcaaattt atggagaaga atggggctat 660
gagaaggagg acattgctga gttctacaag aggcagctaa agctgacaca agagtacacc 720
gaccactgcg tcaagtggta caatgttggg ctggacaagc tccgcggcag cagctatgaa 780
agctgggtga acttcaacag atacaggagg gagatgacgc tcaccgtgct ggacctcatt 840
gctctcttcc cgctctatga tgtgaggctc taccccaagg aggtcaagac agagctgaca 900
agagatgtgc taacagatcc catcgtcggc gtcaacaacc tccgcaccta tggcaccacc 960
ttcagcaaca tcgagaacta catcaggaag ccgcacctct tcgactacct ccaccgcatc 1020
cagttccaca caaggttcca acctggatat tatggaaatg acagcttcaa ctactggagc 1080
ggcaactatg tttcaacaag gccaagcata ggaagcaacg acatcatcac ctcgcccttc 1140
tacggcaaca agagctccga gccggtgcaa aatttggagt tcaatggaga gaaggtgtac 1200
cgcgccgtcg ccaacaccaa cctcgccgtc tggccatcag ctgtctacag cggcgtgacc 1260
aaggtggagt tcagccagta caatgatcaa acagatgaag caagcaccca gacctacgac 1320
agcaagagga acgtcggcgc cgtgtcatgg gacagcatcg accagctgcc gccggagaca 1380
acagatgagc cgctggagaa gggctacagc caccagctca actatgtgat gtgcttcttg 1440
atgcaaggaa gccgcggcac catcccggtg ctgacatgga cccacaagag cgtggacttc 1500
ttcaacatga ttgattcaaa gaagatcacc cagctgccgc tggtgaaggc ctacaagctg 1560
caaagcggcg cctccgtggt ggctgggcca aggttcaccg gcggcgacat catccaatgc 1620
acagaaaatg gaagcgccgc caccatctat gtgacacctg atgtgagcta cagccagaag 1680
tacagagcaa ggattcatta tgcttcaaca agccagatca ccttcacctt gagcttggat 1740
ggagctccct tcaaccagta ctacttcgac aagaccatca acaaaggaga caccttgacc 1800
tacaacagct tcaacctcgc cagcttctca acaccatttg agctgagcgg caacaacctc 1860
cagatcggcg tcaccggcct ctccgccggc gacaaggtct acatcgacaa gattgagttc 1920
atcccggtga actaa                                                  1935

<210> 8
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> AXMI-R1 variant sequence (AXMI-R1(evo19))

<400> 8
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Ile
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Thr Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 9
<211> 1935
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic nucleotide sequence encoding AXMI-R1
      variant sequence (AXMI-R1(evo20))

<400> 9
atgaacccca acaacaggag cgagcatgac accatcaaga caacagagaa caatgaagtt 60
ccaacaaatc atgtgcagta cccgctggcg gagacaccaa atccaacatt ggaggacctc 120
aactacaagg agttcttgag gatgacggcg gacaacaaca cagaagctct ggacagcagc 180
accaccaagg atgtcatcca gaagggcatc tcagtggtgg gagatcttct tggagtggtg 240
ggcttcccct tcggcggcgc gctggttagc ttctacacca acttcctcaa caccatctgg 300
ccatcagaag atccatggaa ggccttcatg gagcaagtgg aggcgctgat ggaccagaag 360
atcgccgact acgccaagaa caaggcgctg gcggagctgc aaggcctcca gaacaatgtt 420
gaagattatg tctcggcgct gagcagctgg cagaagaacg cgaagagctc aagaaatgtg 480
cattctcaag gaaggatcag ggagctcttc agccaagcag aaagccactt cagaaacagc 540
atgccgagct tcgccatctc aggatatgag gtgctcttcc tcaccaccta tgctcaagct 600
gccaacaccc acctcttcct gctgaaggat gctcaaattt atggagaaga atggggctat 660
gagaaggagg acattgctga gttctacaag aggcagctaa agctgacaca agagtacacc 720
gaccactgcg tcaagtggta caatgttggg ctggacaagc tccgcggcag cagctatgaa 780
agctgggtga acttcaacag atacaggagg gagatgacgc tcaccgtgct ggacctcatt 840
gctctcttcc cgctctatga tgtgaggctc taccccaagg aggtcaagac agagctgaca 900
agagatgtgc taacagatcc catcgtcggc gtcaacaacc tccgcaccta tggcaccacc 960
ttcagcaaca tcgagaacta catcaggaag ccgcacctct tcgactacct ccaccgcatc 1020
cagttccaca caaggttcca acctggatat tatggaaatg acagcttcaa ctactggagc 1080
ggcaactatg tttcaacaag gccaagcata ggaagcaacg acatcatcac ctcgcccttc 1140
tacggcaaca agagctccga gccggtgcaa aatttggagt tcaatggaga gaaggtgtac 1200
cgcgccgtcg ccaacaccaa cctcgccgtc tggccatcag ctgtctacag cggcgtgacc 1260
aaggtggagt tcagccagta caatgatcaa acagatgaag caagcaccca gacctacgac 1320
agcaagagga acgtcggcgc cgtgtcatgg gacagcatcg accagctgcc gccggagaca 1380
acagatgagc cgctggagaa gggctacagc caccagctca actatgtgat gtgcttcttg 1440
atgcaaggaa gccgcggcac catcccggtg ctgacatgga cccacaagag cgtggacttc 1500
ttcaacatga ttgattcaaa gaagatcacc cagctgccgc tggtgaaggc ctacaagctg 1560
caaagcggcg cctccgtggt ggctgggcca aggttcaccg gcggcgacat catccaatgc 1620
acagaaaatg gaagcgccgc caccatctat gtgacacctg atgtgagcta cagccagaag 1680
tacagagcaa ggattcatta tgcttcaaca agccagatca ccttcacctt gagcttggat 1740
ggagctccct tcaaccagta ctacttcgac aagaccatca acaaaggaga caccttgacc 1800
tacaacagct tcaacctcgc cagcttctca acaccatttg agctgagcgg caacaacctc 1860
cagatcggcg tcaccggcct ctccgccggc gacaaggtct acatcgacaa gattgagttc 1920
atcccggtga actaa                                                  1935

<210> 10
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> AXMI-R1 variant sequence (AXMI-R1(evo20))

<400> 10
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Ala Lys Ser Ser Arg Asn Val
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Thr Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 11
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> endoplasmic reticulum signal sequence

<400> 11
Lys Asp Glu Leu
 1              


<210> 12
<211> 1932
<212> DNA
<213> Artificial Sequence

<220> 
<223> nucleotide sequence encoding variant of Axmi-R1
      (Axmi-R1(3c7))

<400> 12
atgaatccga acaatcgaag tgaacatgat acaataaaaa ctactgaaaa taatgaggtg 60
ccaactaacc atgttcaata tcctttagcg gaaactccaa atccaacact agaagattta 120
aattataaag agtttttaag aatgactgca gataataata cggaagcact agatagctct 180
acaacaaaag atgtcattca aaaaggcatt tccgtagtag gtgatctcct aggcgtagta 240
ggtttcccgt ttggtggagc gcttgtttcg ttttatacaa actttttaaa tactatttgg 300
ccaagtgaag acccgtggaa ggcttttatg gaacaagtag aagcattgat ggatcagaaa 360
atagctgatt atgcaaaaaa taaagctctt gcagagttac agggccttca aaataatgtc 420
gaagattatg tgagtgcatt gagttcatgg caaaaaaatg caaagagttc acgaaatgta 480
catagccagg ggcggataag agagctgttt tctcaagcag aaagtcattt tcgtaattca 540
atgccttcgt ttgcaatttc tggatacgag gttctatttc taacaacata tgcacaagct 600
gccaacacac atttattttt actaaaagac gctcaaattt atggagaaga atggggatac 660
gaaaaagaag atattgctga attttataaa agacaactaa aacttacgca agaatatact 720
gaccattgtg tcaaatggta taatgttgga ttagataaat taagaggttc atcttatgaa 780
tcttgggtaa actttaaccg ttatcgcaga gagatgacat taacagtatt agatttaatt 840
gcactatttc cattgtatga tgttcggcta tacccaaaag aagttaaaac cgaattaaca 900
agagacgttt taacagatcc aattgtcgga gtcaacaacc ttaggggcta tggaacaacc 960
ttctctaata tagaaaatta tattcgaaaa ccacatctat ttgactatct gcatagaatt 1020
caatttcaca cgcggttcca accaggatat tatggaaatg actctttcaa ttattggtcc 1080
ggtaattatg tttcaactag accaagcata ggatcaaatg atataatcac atctccattc 1140
tatggaaata aatccagtga acctgtacaa aatttagaat ttaatggaga aaaagtctat 1200
agagccgtag caaatacaaa tcttgcggtc tggccgtccg ctgtatattc aggtgttaca 1260
aaagtggaat ttagccaata taatgatcaa acagatgaag caagtacaca aacgtacgac 1320
tcaaaaagaa atgttggcgc ggtcagctgg gattctatcg atcaattgcc tccagaaaca 1380
acagatgaac ctctagaaaa gggatatagc catcaactca attatgtaat gtgcttttta 1440
atgcagggta gtagaggaac aatcccagtg ttaacttgga cacataaaag tgtagacttt 1500
tttaacatga ttgattcgaa aaaaattaca caacttccgt tagtaaaggc atataagtta 1560
caatctggtg cttccgttgt cgcaggtcct aggtttacag gaggagatat cattcaatgc 1620
acagaaaatg gaagtgcggc aactatttac gttacaccgg atgtgtcgta ctctcaaaaa 1680
tatcgagcta gaattcatta tgcttctaca tctcagataa catttacact cagtttagac 1740
ggggcaccat ttaatcaata ctatttcgat aaaacgataa ataaaggaga cacattaacg 1800
tataattcat ttaatttagc aagtttcagc acaccattcg aattatcagg gaataactta 1860
caaataggcg tcacaggatt aagtgctgga gataaagttt atatagacaa aattgaattt 1920
attccagtga at                                                     1932

<210> 13
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant of Axmi-R1 (Axmi-R1(3c7))

<400> 13
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Ala Lys Ser Ser Arg Asn Val
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 14
<211> 1932
<212> DNA
<213> Artificial Sequence

<220> 
<223> nucleotide sequence encoding variant of Axmi-R1
      (Axmi-R1(1g8))

<400> 14
atgaatccga acaatcgaag tgaacatgat acaataaaaa ctactgaaaa taatgaggtg 60
ccaactaacc atgttcaata tcctttagcg gaaactccaa atccaacact agaagattta 120
aattataaag agtttttaag aatgactgca gataataata cggaagcact agatagctct 180
acaacaaaag atgtcattca aaaaggcatt tccgtagtag gtgatctcct aggcgtagta 240
ggtttcccgt ttggtggagc gcttgtttcg ttttatacaa actttttaaa tactatttgg 300
ccaagtgaag acccgtggaa ggcttttatg gaacaagtag aagcattgat ggatcagaaa 360
atagctgatt atgcaaaaaa taaagctctt gcagagttac agggccttca aaataatgtc 420
gaagattatg tgagtgcatt gagttcatgg caaaaaaatc ctgtgagttc acgaaatcca 480
catagccagg ggcggataag agagctgttt tctcaagcag aaagtcattt tcgtaattca 540
atgccttcgt ttgcaatttc tggatacgag gttctatttc taacaacata tgcacaagct 600
gccaacacac atttattttt actaaaagac gctcaaattt atggagaaga atggggatac 660
gaaaaagaag atattgctga attttataaa agacaactaa aacttacgca agaatatact 720
gaccattgtg tcaaatggta taatgttgga ttagataaat taagaggttc atcttatgaa 780
tcttgggtaa actttaaccg ttatcgcaga gagatgacat taacagtatt agatttaatt 840
gcactatttc cattgtatga tgttcggcta tacccaaaag aagttaaaac cgaattaaca 900
agagacgttt taacagatcc aattgtcgga gtcaacaacc ttagggaata tggaacaacc 960
ttctctaata tagaaaatta tattcgaaaa ccacatctat ttgactatct gcatagaatt 1020
caatttcaca cgcggttcca accaggatat tatggaaatg actctttcaa ttattggtcc 1080
ggtaattatg tttcaactag accaagcata ggatcaaatg atataatcac atctccattc 1140
tatggaaata aatccagtga acctgtacaa aatttagaat ttaatggaga aaaagtctat 1200
agagccgtag caaatacaaa tcttgcggtc tggccgtccg ctgtatattc aggtgttaca 1260
aaagtggaat ttagccaata taatgatcaa acagatgaag caagtacaca aacgtacgac 1320
tcaaaaagaa atgttggcgc ggtcagctgg gattctatcg atcaattgcc tccagaaaca 1380
acagatgaac ctctagaaaa gggatatagc catcaactca attatgtaat gtgcttttta 1440
atgctgaaaa gtagaggaac aatcccagtg ttaacttgga cacataaaag tgtagacttt 1500
tttaacatga ttgattcgaa aaaaattaca caacttccgt tagtaaaggc atataagtta 1560
caatctggtg cttccgttgt cgcaggtcct aggtttacag gaggagatat cattcaatgc 1620
acagaaaatg gaagtgcggc aactatttac gttacaccgg atgtgtcgta ctctcaaaaa 1680
tatcgagcta gaattcatta tgcttctaca tctcagataa catttacact cagtttagac 1740
ggggcaccat ttaatcaata ctatttcgat aaaacgataa ataaaggaga cacattaacg 1800
tataattcat ttaatttagc aagtttcagc acaccattcg aattatcagg gaataactta 1860
caaataggcg tcacaggatt aagtgctgga gataaagttt atatagacaa aattgaattt 1920
attccagtga at                                                     1932

<210> 15
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant of Axmi-R1 (Axmi-R1(1g8))

<400> 15
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Glu Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Leu Lys Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 16
<211> 1932
<212> DNA
<213> Artificial Sequence

<220> 
<223> nucleotide sequence encoding variant of Axmi-R1
      (Axmi-R1(Evo23))

<400> 16
atgaatccga acaatcgaag tgaacatgat acaataaaaa ctactgaaaa taatgaggtg 60
ccaactaacc atgttcaata tcctttagcg gaaactccaa atccaacact agaagattta 120
aattataaag agtttttaag aatgactgca gataataata cggaagcact agatagctct 180
acaacaaaag atgtcattca aaaaggcatt tccgtagtag gtgatctcct aggcgtagta 240
ggtttcccgt ttggtggagc gcttgtttcg ttttatacaa actttttaaa tactatttgg 300
ccaagtgaag acccgtggaa ggcttttatg gaacaagtag aagcattgat ggatcagaaa 360
atagctgatt atgcaaaaaa taaagctctt gcagagttac agggccttca aaataatgtc 420
gaagattatg tgagtgcatt gagttcatgg caaaaaaatc atgtgagttc acgaaatctt 480
catagccagg ggcggataag agagctgttt tctcaagcag aaagtcattt tcgtaattca 540
atgccttcgt ttgcaatttc tggatacgag gttctatttc taacaacata tgcacaagct 600
gccaacacac atttattttt actaaaagac gctcaaattt atggagaaga atggggatac 660
gaaaaagaag atattgctga attttataaa agacaactaa aacttacgca agaatatact 720
gaccattgtg tcaaatggta taatgttgga ttagataaat taagaggttc atcttatgaa 780
tcttgggtaa actttaaccg ttatcgcaga gagatgacat taacagtatt agatttaatt 840
gcactatttc cattgtatga tgttcggcta tacccaaaag aagttaaaac cgaattaaca 900
agagacgttt taacagatcc aattgtcgga gtcaacaacc ttagggaata tggaacaacc 960
ttctctaata tagaaaatta tattcgaaaa ccacatctat ttgactatct gcatagaatt 1020
caatttcaca cgcggttcca accaggatat tatggaaatg actctttcaa ttattggtcc 1080
ggtaattatg tttcaactag accaagcata ggatcaaatg atataatcac atctccattc 1140
tatggaaata aatccagtga acctgtacaa aatttagaat ttaatggaga aaaagtctat 1200
agagccgtag caaatacaaa tcttgcggtc tggccgtccg ctgtatattc aggtgttaca 1260
aaagtggaat ttagccaata taatgatcaa acagatgaag caagtacaca aacgtacgac 1320
tcaaaaagaa atgttggcgc ggtcagctgg gattctatcg atcaattgcc tccagaaaca 1380
acagatgaac ctctagaaaa gggatatagc catcaactca attatgtaat gtgcttttta 1440
atgctgaaaa gtagaggaac aatcccagtg ttaacttgga cacataaaag tgtagacttt 1500
tttaacatga ttgattcgaa aaaaattaca caacttccgt tagtaaaggc atataagtta 1560
caatctggtg cttccgttgt cgcaggtcct aggtttacag gaggagatat cattcaatgc 1620
acagaaaatg gaagtgcggc aactatttac gttacaccgg atgtgtcgta ctctcaaaaa 1680
tatcgagcta gaattcatta tgcttctaca tctcagataa catttacact cagtttagac 1740
ggggcaccat ttaatcaata ctatttcgat aaaacgataa ataaaggaga cacattaacg 1800
tataattcat ttaatttagc aagtttcagc acaccattcg aattatcagg gaataactta 1860
caaataggcg tcacaggatt aagtgctgga gataaagttt atatagacaa aattgaattt 1920
attccagtga at                                                     1932

<210> 17
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant of Axmi-R1 (Axmi-R1(Evo23))

<400> 17
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn His Val Ser Ser Arg Asn Leu
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Glu Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Leu Lys Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 18
<211> 1932
<212> DNA
<213> Artificial Sequence

<220> 
<223> nucleotide sequence encoding variant of Axmi-R1
      (Axmi-R1(L61E11)) (Axmi-R1(L61E11))
      (Axmi-R1(Evo23))

<400> 18
atgaatccga acaatcgaag tgaacatgat acaataaaaa ctactgaaaa taatgaggtg 60
ccaactaacc atgttcaata tcctttagcg gaaactccaa atccaacact agaagattta 120
aattataaag agtttttaag aatgactgca gataataata cggaagcact agatagctct 180
acaacaaaag atgtcattca aaaaggcatt tccgtagtag gtgatctcct aggcgtagta 240
ggtttcccgt ttggtggagc gcttgtttcg ttttatacaa actttttaaa tactatttgg 300
ccaagtgaag acccgtggaa ggcttttatg gaacaagtag aagcattgat ggatcagaaa 360
atagctgatt atgcaaaaaa taaagctctt gcagagttac agggccttca aaataatgtc 420
gaagattatg tgagtgcatt gagttcatgg caaaaaaatc ctgtgagttc acgaaatcca 480
catagccagg ggcggataag agagctgttt tctcaagcag aaagtcattt tcgtaattca 540
atgccttcgt ttgcaatttc tggatacgag gttctatttc taacaacata tgcacaagct 600
gccaacacac atttattttt actaaaagac gctcaaattt atggagaaga atggggatac 660
gaaaaagaag atattgctga attttataaa agacaactaa aacttacgca agaatatact 720
gaccattgtg tcaaatggta taatgttgga ttagataaat taagaggttc atcttatgaa 780
tcttgggtaa actttaaccg ttatcgcaga gagatgacat taacagtatt agatttaatt 840
gcactatttc cattgtatga tgttcggcta tacccaaaag aagttaaaac cgaattaaca 900
agagacgttt taacagatcc aattgtcgga gtcaacaacc ttaggggcta tggaacaacc 960
ttctctaata tagaaaatta tattcgaaaa ccacatctat ttgactatct gcatagaatt 1020
caatttcaca cgcggttcca accaggatat tatggaaatg actctttcaa ttattggtcc 1080
ggtaattatg tttcaactag accaagcata ggatcaaatg atataatcac atctccattc 1140
tatggaaata aatccagtga acctgtacaa aatttagaat ttaatggaga aaaagtctat 1200
agagccgtag caaatacaaa tcttgcggtc tggccgtccg ctgtatattc aggtgttaca 1260
aaagtggaat ttagccaata taatgatcaa acagatgaag caagtacaca aacgtacgac 1320
tcaaaaagaa atgttggcgc ggtcagctgg gattctatcg atcaattgcc tccagaaaca 1380
acagatgaac ctctagaaaa gggatatagc catcaactca attatgtaat gtgcttttta 1440
atgcagggta gtagaggaac aatcccagtg ttaacttgga cacataaaag tgtagacttt 1500
tttaacatga ttgattcgaa aaaaattaca caacttccgt tagtaaaggc atataattta 1560
caatctggtg cttccgttgt cgcaggtcct aggtttacag gaggagatat cattcaatgc 1620
acagaaaatg gaagtgcggc aactatttac gttacaccgg atgtgtcgta ctctcaaaaa 1680
tatcgagcta gaattcatta tgcttctaca tctcagataa catttacact cagtttagac 1740
ggggcaccat ttaatcaata ctatttcgat aaaacgataa ataaaggaga cacattaacg 1800
tataattcat ttaatttagc aagtttcagc acaccattcg aattatcagg gaataactta 1860
caaataggcg tcacaggatt aagtgctgga gataaagttt atatagacaa aattgaattt 1920
attccagtga at                                                     1932

<210> 19
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant of Axmi-R1 (Axmi-R1(L61E11))

<400> 19
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Asn Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 20
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic tetrapeptide

<400> 20
Ala Ala Pro Phe
 1              


<210> 21
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (D4F11)

<400> 21
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Ala Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 22
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (H9)

<400> 22
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Ile
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 23
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (G5)

<400> 23
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Ala
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 24
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (H4)

<400> 24
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Phe
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 25
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (D4A2)

<400> 25
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gln Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 26
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (H4+D5D8)

<400> 26
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Phe
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Thr Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 27
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (H9+D4A2)

<400> 27
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Ile
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gln Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 28
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (G5+D4A2)

<400> 28
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Ala
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gln Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 29
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (R315M)

<400> 29
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Met Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 30
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (R315W)

<400> 30
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Trp Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 31
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (3c6)

<400> 31
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Gln Glu Ser Ser Arg Asn Leu
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 32
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (3a11)

<400> 32
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Lys Ser Ser Gly Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Thr Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 33
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (2b11)

<400> 33
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Ala Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Leu Lys Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 34
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (Q482I)

<400> 34
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Ile Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 35
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (G483K)

<400> 35
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Lys Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 36
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (G483S)

<400> 36
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Ser Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 37
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (G483Q)

<400> 37
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gln Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 38
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (3c7+1g8)

<400> 38
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Ala Lys Ser Ser Val Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Glu Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Leu Lys Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 39
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (3c7+2b11)

<400> 39
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Ala Lys Ser Ser Val Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Ala Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Leu Lys Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 40
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (G5+D5D8)

<400> 40
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Ala
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Thr Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 41
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (D4F11+D5D8)

<400> 41
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Ala Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Thr Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 42
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (H4+D4A2)

<400> 42
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Val Ser Ser Arg Asn Phe
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gln Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 43
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant Axmi-R1 (D4F11+D4A2)

<400> 43
Met Asn Pro Asn Asn Arg Ser Glu His Asp Thr Ile Lys Thr Thr Glu
 1               5                  10                  15      
Asn Asn Glu Val Pro Thr Asn His Val Gln Tyr Pro Leu Ala Glu Thr
            20                  25                  30          
Pro Asn Pro Thr Leu Glu Asp Leu Asn Tyr Lys Glu Phe Leu Arg Met
        35                  40                  45              
Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys Asp
    50                  55                  60                  
Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val
65                  70                  75                  80  
Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu
                85                  90                  95      
Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln
            100                 105                 110         
Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys
        115                 120                 125             
Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val
    130                 135                 140                 
Ser Ala Leu Ser Ser Trp Gln Lys Asn Ala Val Ser Ser Arg Asn Pro
145                 150                 155                 160 
His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His
                165                 170                 175     
Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu
            180                 185                 190         
Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu
        195                 200                 205             
Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp
    210                 215                 220                 
Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr
225                 230                 235                 240 
Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly
                245                 250                 255     
Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met
            260                 265                 270         
Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val
        275                 280                 285             
Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu
    290                 295                 300                 
Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gln Tyr Gly Thr Thr
305                 310                 315                 320 
Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr
                325                 330                 335     
Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly
            340                 345                 350         
Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro
        355                 360                 365             
Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys
    370                 375                 380                 
Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr
385                 390                 395                 400 
Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr
                405                 410                 415     
Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp
            420                 425                 430         
Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val
        435                 440                 445             
Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro
    450                 455                 460                 
Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu
465                 470                 475                 480 
Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys
                485                 490                 495     
Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu
            500                 505                 510         
Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val Val Ala
        515                 520                 525             
Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu Asn Gly
    530                 535                 540                 
Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser Gln Lys
545                 550                 555                 560 
Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr Phe Thr
                565                 570                 575     
Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp Lys Thr
            580                 585                 590         
Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu Ala Ser
        595                 600                 605             
Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile Gly Val
    610                 615                 620                 
Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile Glu Phe
625                 630                 635                 640 
Ile Pro Val Asn
                


<210> 44
<211> 1166
<212> PRT
<213> Bacillus thuringiensis

<400> 44
Met Ser Pro Asn Asn Gln Asn Glu Tyr Glu Ile Lys Asp Ala Thr Pro
 1               5                  10                  15      
Ser Thr Ser Val Ser Ser Asp Ser Ala Arg Tyr Pro Phe Ala Asn Glu
            20                  25                  30          
Pro Thr Asn Ala Leu Gln Asn Met Asn Tyr Lys Glu Tyr Leu Arg Met
        35                  40                  45              
Ser Glu Gly His Asp Ala Ala Tyr Phe Ser Asn Pro Glu Ala Phe Val
    50                  55                  60                  
Asp Thr Lys Ser Ile Gln Ala Ile Ile Asn Val Ile Gly Lys Ala Leu
65                  70                  75                  80  
Gly Ala Leu Gly Val Pro Gly Ala Gly Ile Ile Ala Ser Phe Tyr Ser
                85                  90                  95      
Phe Ile Val Gly Gln Leu Trp Pro Ser Asn Ser Val Ser Leu Trp Glu
            100                 105                 110         
Gln Ile Met Glu Gln Val Glu Glu Leu Ile Asp Gln Lys Ile Thr Glu
        115                 120                 125             
Tyr Ala Arg Asn Lys Ala Leu Thr Glu Leu Lys Gly Leu Gly Asp Ala
    130                 135                 140                 
Leu Asp Val Tyr Gln Glu Ser Leu Glu Ala Trp Leu Glu Asn Arg Asn
145                 150                 155                 160 
Asp Thr Arg Ala Arg Ser Val Val Ser Lys Gln Phe Ile Ala Leu Glu
                165                 170                 175     
Leu Asp Phe Val Gly Ala Ile Pro Ser Phe Ala Val Ser Asn Gln Glu
            180                 185                 190         
Val Pro Leu Leu Ala Val Tyr Ala Gln Ala Ala Asn Leu His Leu Leu
        195                 200                 205             
Leu Leu Arg Asp Ala Ser Ile Phe Gly Ala Asp Trp Gly Phe Ser Ser
    210                 215                 220                 
Ser Glu Ile Ser Thr Tyr Tyr Asn Arg Gln Val Arg Leu Thr Ser Gln
225                 230                 235                 240 
Tyr Ser Asp Tyr Cys Val Lys Trp Tyr Asn Thr Gly Leu Asp Lys Leu
                245                 250                 255     
Lys Gly Thr Asn Ser Ala Ser Trp Leu Lys Tyr His Gln Phe Arg Arg
            260                 265                 270         
Glu Met Thr Leu Met Val Leu Asp Val Val Ala Leu Phe Pro Asn Tyr
        275                 280                 285             
Asn Thr Gln Thr Tyr Pro Ile Glu Thr Arg Ala Gln Leu Thr Arg Asp
    290                 295                 300                 
Val Tyr Thr Asp Pro Ala Ala Phe Asn Asn Val Ser Asp Tyr Gly Phe
305                 310                 315                 320 
Cys Asn Pro Trp Ser Thr His Ser Gly Ile Leu Phe Ser Glu Val Glu
                325                 330                 335     
Asn Ala Val Ile Arg Ser Pro His Leu Phe Asp Ile Leu Ser Ser Ile
            340                 345                 350         
Glu Ile Asn Thr Ala Arg Gly Gly Ile Ala Leu Asn Asn Thr Ala Tyr
        355                 360                 365             
Ile Asn Tyr Trp Ser Gly His Ser Leu Lys Tyr His Glu Thr Asn Asn
    370                 375                 380                 
Pro Thr Ile Arg Ala Val Asn Tyr Gly Arg Ile Thr Ser Glu Lys Asn
385                 390                 395                 400 
Ser Leu Val Leu Glu Asp Arg Glu Ile Phe Glu Thr Ile Ser Val Val
                405                 410                 415     
Ala Asn Leu Ala Asn Val Tyr Gln Lys Ala Tyr Gly Val Pro Glu Ser
            420                 425                 430         
Tyr Phe Asn Met Thr Arg Arg Gly Thr Ser Ser Thr Ser Tyr Tyr Phe
        435                 440                 445             
Tyr Ser Lys Thr His Thr Thr Pro Tyr Gly Cys Ser Asp Val Tyr Pro
    450                 455                 460                 
Ser Tyr Ser Asp Ile Pro Ile Asp Arg Asn Val Pro Val Ala Glu Ser
465                 470                 475                 480 
Tyr Ser His Arg Leu Ser His Ile Thr Phe His Ser Phe Ser Lys Asn
                485                 490                 495     
Ser Asn Ala Ile Tyr Gly Ser Phe Pro Val Phe Val Trp Thr His Val
            500                 505                 510         
Ser Ala Asp Leu Thr Asn Thr Ile Tyr Pro Asp Ala Ile Thr Gln Leu
        515                 520                 525             
Pro Met Val Lys Ala Asn Ala Leu Leu Ser Gly Thr Ser Val Ile Lys
    530                 535                 540                 
Gly Pro Gly Ser Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Val Gly
545                 550                 555                 560 
Arg Val Gly Asn Phe Lys Val Asn Val Asn Gly Pro Leu Thr Gln Arg
                565                 570                 575     
Tyr Leu Val Arg Ile Arg Tyr Ala Ser Thr Thr Asp Leu Asp Phe Tyr
            580                 585                 590         
Val Tyr Arg Gly Gly Thr Thr Val Ser Asn Tyr Arg Phe Asn Lys Thr
        595                 600                 605             
Met Asn Lys Gly Ala Ser Leu Thr Tyr Asp Ile Phe Lys Phe Ala Ser
    610                 615                 620                 
Phe Ser Thr Pro Phe Thr Phe Thr Lys Thr Gln Asp Glu Leu Gly Ile
625                 630                 635                 640 
Ser Ile Gln Asn Phe Ser Ser Gly Glu Glu Val Tyr Ile Asp Arg Ile
                645                 650                 655     
Glu Val Ile Pro Val Gly Thr Thr Tyr Glu Ala Glu Thr Asp Leu Glu
            660                 665                 670         
Ile Ala Lys Arg Ala Val Asn Thr Leu Phe Thr Asn Thr Lys Asp Gly
        675                 680                 685             
Leu Arg Pro Gly Val Thr Asp Tyr Glu Val Asn Gln Ala Ala Asn Leu
    690                 695                 700                 
Val Glu Cys Leu Ser Asp Asp Leu Tyr Pro Asn Glu Lys Arg Leu Leu
705                 710                 715                 720 
Phe Asp Ala Val Lys Glu Ala Lys Arg Leu Ser Gly Val Arg Asn Leu
                725                 730                 735     
Leu Gln Asp Ser Asp Phe Gln Glu Ile Asn Gly Glu Asn Gly Trp Thr
            740                 745                 750         
Gly Ser Thr Gly Ser Thr Gly Ile Glu Ile Val Glu Gly Asp Ala Leu
        755                 760                 765             
Phe Lys Gly Arg Tyr Leu Arg Leu Pro Gly Ala Pro Glu Ile Asp Thr
    770                 775                 780                 
Glu Thr Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Gly Leu Leu
785                 790                 795                 800 
Lys Pro Tyr Thr Arg Tyr Arg Leu Arg Gly Phe Val Gly Ser Ser Gln
                805                 810                 815     
Gly Leu Glu Ile Tyr Thr Ile Arg His Gln Thr Asn Arg Ile Val Lys
            820                 825                 830         
Asn Val Pro Asp Asp Leu Leu Pro Asp Val Ser Leu Val Ser Ala Gly
        835                 840                 845             
Asp Gly Ile Asn Arg Cys Ser Glu Gln Lys Tyr Val Asn Ser Arg Leu
    850                 855                 860                 
Glu Gly Glu Arg Gly Leu Pro Asn Gly Asn Arg Ser Ala Asp Ala His
865                 870                 875                 880 
Glu Phe Ser Ile Gln Ile Asp Thr Gly Glu Ile Asp Leu Asn Gly Asn
                885                 890                 895     
Glu Gly Ile Trp Val Gly Phe Lys Val Ala Thr Pro Asp Gly Tyr Ala
            900                 905                 910         
Thr Leu Gly Asn Leu Glu Leu Val Glu Glu Gly Pro Leu Ser Gly Asp
        915                 920                 925             
Ala Leu Glu Arg Val Gln Arg Glu Glu Gln Gln Trp Lys Ile Arg Met
    930                 935                 940                 
Thr Lys Arg Arg Glu Glu Thr Asp Arg Lys Tyr Thr Ala Ala Lys Gln
945                 950                 955                 960 
Ala Val Asp Arg Leu Tyr Ala Asp Tyr Gln Asp Gln Gln Leu Asn Pro
                965                 970                 975     
Asn Val Glu Ile Thr Asp Ile Thr Ala Ala Gln Asn Leu Ile Gln Ser
            980                 985                 990         
Ile Pro Tyr Val Tyr Asn Asp Val Phe Pro Gly Leu Pro Gly Met Asn
        995                 1000                1005            
Tyr Ala Lys Tyr Thr Glu Leu Thr Asn Arg Leu Gln Gln Ala Trp Ser
    1010                1015                1020                
Leu Tyr Glu Gln Arg Asn Val Ile Pro Asn Gly Asp Phe Arg Asn Glu
1025                1030                1035               1040 
Leu Asn Asn Trp Asn Thr Thr Ser Gly Val Asn Val Gln Gln Ile Asn
                1045                1050                1055    
Asp Arg Ser Val Leu Val Ile Pro Asn Trp Asp Glu Gln Val Ser Gln
            1060                1065                1070        
Gln Phe Thr Val Gln Pro Asn Gln Arg Tyr Val Leu Arg Val Thr Ala
        1075                1080                1085            
Arg Lys Glu Gly Val Gly Asn Gly Tyr Val Ser Ile Arg Asp Gly Gly
    1090                1095                1100                
Asn Gln Thr Glu Thr Leu Thr Phe Ser Ala Asn Glu Tyr Asp Thr Asn
1105                1110                1115               1120 
Gly Val Tyr Asn Asp Gln Ile Gly Tyr Ile Thr Lys Thr Val Ala Phe
                1125                1130                1135    
Ile Pro Tyr Thr Asp Gln Val Trp Met Asp Ile Ser Glu Thr Glu Gly
            1140                1145                1150        
Val Leu Tyr Ile Glu Gly Val Lys Leu Val Val Asp Val Glu
        1155                1160                1165    


<210> 45
<211> 1168
<212> PRT
<213> Bacillus thuringiensis

<400> 45
Met Lys Val Arg Leu Leu Met Asn Lys Asn Tyr Leu Ser Lys Ser Gln
 1               5                  10                  15      
Asp Leu Thr Gln Ile Ser Glu Ile Phe Gly Tyr Asp Pro Ile His Pro
            20                  25                  30          
Leu Val Asn Pro Lys Asn His Ile Glu Ser Leu Arg Val Asn Arg Asn
        35                  40                  45              
Glu Leu Arg Thr Leu Pro Glu Gly Phe Ala Ser Ser Thr Glu Ser Ala
    50                  55                  60                  
Ile Thr Asn Thr Leu Asn Ile Ile Ser Ile Leu Leu Asp Ala Ser Gly
65                  70                  75                  80  
His Pro Ala Ala Ala Arg Val Leu Gly Val Ile Thr Gly Ile Ile Gly
                85                  90                  95      
Ile Leu Trp Pro Gly Gly Ser Gln Lys Thr Trp Glu Glu Phe Met Ala
            100                 105                 110         
Ala Val Glu Ala Leu Ile Asp Glu Lys Ile Thr Glu Ser Phe Lys Asn
        115                 120                 125             
Glu Ala Ile Ser Lys Leu Asn Gly Leu Ala Asp Leu Tyr Thr Val Tyr
    130                 135                 140                 
Leu Ser Glu Leu Glu Leu Trp Leu Glu His Pro His Asp Pro Ser Ile
145                 150                 155                 160 
Ile Gln Ser Val Arg Thr Arg Phe Leu Asp Leu Asp Ser Glu Phe Ile
                165                 170                 175     
Ser Ser Met Pro Gln Phe Ala Ile Ser Gly Phe Glu Val Ser Phe Leu
            180                 185                 190         
Pro Val Tyr Ala Gln Ala Ala Asn Leu His Leu Leu Leu Leu Arg Asp
        195                 200                 205             
Leu Ser Tyr Tyr Gly Asn Asp Trp Gly Leu Gln Gln Pro Glu Ile Glu
    210                 215                 220                 
Asn Tyr Tyr Asn Arg Gln Ile Asn Asn Ile Gln Lys Tyr Thr Asp His
225                 230                 235                 240 
Cys Val Lys Trp Tyr Gln Leu Gly Leu Gln Asp Val Tyr Asn Lys Tyr
                245                 250                 255     
Asn Ser Thr Ile Ile Asn Glu Asp Gly Gly Leu Pro Trp Thr His Tyr
            260                 265                 270         
Asn Arg Tyr Arg Arg Glu Met Thr Ile Leu Val Leu Asp Leu Val Ala
        275                 280                 285             
Thr Phe Ser Thr Asn Asp Trp Lys Lys Tyr Tyr Leu Glu Thr Asn Val
    290                 295                 300                 
Glu Leu Ser Arg Glu Ile Tyr Thr Asp Pro Leu Gly Tyr Glu Asp Ser
305                 310                 315                 320 
Asp Glu Gly Asn Ile Thr Asp Val Asp Trp Tyr Ser Glu Gly Val Ser
                325                 330                 335     
Phe Ser Thr Ile Glu Asn Leu His Ser Pro Lys Leu Val Glu Trp Leu
            340                 345                 350         
Lys Arg Ile Thr Ile Gln Thr Asp Tyr Phe Ser Ala Gly Ser Asp Glu
        355                 360                 365             
Ser Tyr Cys Trp Ala Gly His Tyr Ile Tyr Thr Thr Phe Thr Asp Ser
    370                 375                 380                 
Asp Lys Glu Tyr Ser Arg Tyr Tyr Gly Asn Pro Glu Asn Val Glu Ser
385                 390                 395                 400 
Thr Thr Ser Tyr Thr Phe Ala Pro Ala Glu Val Tyr Lys Val Glu Ser
                405                 410                 415     
Val Val Gly Ser Glu Arg Asn Ala Thr Tyr Asp Asn Tyr Val Asn Ser
            420                 425                 430         
Ala Asn Thr Phe Tyr Gln Val Thr Pro Thr Asn Glu Leu Lys Lys Phe
        435                 440                 445             
Ile Tyr Ser Tyr Arg Asn Asp Tyr Asp Lys Lys Thr Leu Tyr Ser Asp
    450                 455                 460                 
Asp Gln Leu Pro Leu Glu Thr Asp Pro Pro Lys Tyr Gly Glu Tyr Ser
465                 470                 475                 480 
His Arg Leu Ser Asn Ile Thr Cys Ala Pro Leu Asn Ser Asp Asp Phe
                485                 490                 495     
Gly Leu Val Pro Ile Leu Gly Trp Thr His Thr Ser Leu Lys Arg Glu
            500                 505                 510         
Asn Ile Ile Tyr Pro Asp Lys Ile Thr Gln Ile Pro Ala Val Lys Ser
        515                 520                 525             
Phe Ser Thr Glu Gly Thr Trp Glu Arg Val Ala Ala Gly Pro Gly Phe
    530                 535                 540                 
Thr Gly Gly Asn Val Thr Gln Ala Thr Asn Thr Val Thr Ser Gly Ile
545                 550                 555                 560 
Lys Thr Thr Asp Leu Val Lys Ile Arg Val Arg Ile Asp Ser Thr Ala
                565                 570                 575     
Ser Ser Lys Gln Tyr Arg Val Arg Leu Arg Tyr Ala Ser Asn Gln Asp
            580                 585                 590         
Phe Ser His Ala His Phe Tyr Thr Gly Thr Gly Ser Asn Glu Thr Thr
        595                 600                 605             
Phe Ser Leu Lys Lys Thr Thr Asp Phe Pro Phe Ala Asn Tyr Asn Ser
    610                 615                 620                 
Phe Gly Tyr Val Glu Ile Pro Arg Val Leu Lys Phe Ser Ser Gly Ser
625                 630                 635                 640 
Glu Ile Ile Asn Val Tyr Val Tyr Pro Glu Asn Gly Leu Lys Val Gln
                645                 650                 655     
Val Asp Lys Ile Glu Phe Ile Pro Val Asp Asp Asn Tyr Glu Asp Arg
            660                 665                 670         
Val Thr Leu Glu Lys Ala Gln Lys Ala Val Asn Thr Leu Phe Thr Val
        675                 680                 685             
Gly Arg Asn Ala Leu Gln Thr Asp Val Thr Asp Tyr Lys Val Asp Gln
    690                 695                 700                 
Val Ser Ile Leu Val Asp Cys Val Ser Glu Glu Leu Tyr Pro Asn Glu
705                 710                 715                 720 
Lys Lys Glu Leu Gln Asn Leu Val Lys Tyr Ala Lys Arg Leu Ser Ile
                725                 730                 735     
Ser Arg Asn Leu Leu Leu Asp Pro Asn Phe Thr Ser Ile Asn Ala Pro
            740                 745                 750         
Lys Ile Arg Gly Trp His Gly Ser Gln Gly Ile Phe Val Gly Asn Gly
        755                 760                 765             
Asn Tyr Ile Phe Lys Gly Pro Tyr Val His Leu Gln Gly Thr Asn Asp
    770                 775                 780                 
Ala Gln Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu
785                 790                 795                 800 
Lys Glu Tyr Ile Arg Tyr Lys Leu Arg Gly Phe Ile Glu Ser Ser Gln
                805                 810                 815     
Asp Leu Glu Val Tyr Val Ile Arg Tyr Asp Val Lys Arg Glu Thr Leu
            820                 825                 830         
Asp Val Ser Asn Asn Leu Ser Ser Asp Asp Thr Pro Ala Asn Ala Cys
        835                 840                 845             
Gly Gly Pro Asn Arg Cys Ile Glu Gln Gln Tyr Leu Asp Asp Asn Pro
    850                 855                 860                 
Thr Leu Glu Cys Ser Ser Ile Gln Asp Gly Ile Leu Phe Asp Ser His
865                 870                 875                 880 
Ser Phe Ser Leu Asn Ile Asp Thr Gly Ser Ile Asp Tyr Asn Glu Asn
                885                 890                 895     
Val Gly Ile Trp Val Val Phe Lys Ile Ser Thr Leu Glu Gly Tyr Ala
            900                 905                 910         
Lys Leu Gly Asn Val Glu Val Ile Glu Asp Gly Pro Leu Val Gly Glu
        915                 920                 925             
Ala Leu Ala Arg Val Lys Arg Gln Glu Thr Lys Trp Arg Asn Lys Leu
    930                 935                 940                 
Ala Gln Leu Arg Thr Glu Thr Gln Ala Ile Tyr Thr Arg Ala Lys Gln
945                 950                 955                 960 
Ser Leu Asp Asn Leu Phe Ile Asp Ala Gln Asp Ala His Leu Lys Ile
                965                 970                 975     
Gly Thr Pro Phe Ala Ala Ile Val Ala Ala Arg Glu Ala Val Gln Ser
            980                 985                 990         
Ile Arg Glu Val Tyr Met Pro Trp Leu Ser Val Val Ala Gly Val Asn
        995                 1000                1005            
Tyr Pro Ile Phe Thr Glu Leu Asn Leu Arg Val Arg Arg Ala Leu Gln
    1010                1015                1020                
Leu Tyr Asp Leu Arg Asn Val Val Arg Asn Gly Arg Phe Arg Asn Gly
1025                1030                1035               1040 
Leu Ser Asn Trp Asn Val Thr Ser Asp Val Glu Val Gln Glu Glu Asn
                1045                1050                1055    
Gly Asn Asn Val Leu Val Leu Ser Asn Trp Asp Ala Gln Val Leu Gln
            1060                1065                1070        
Cys Ile Lys Leu Tyr Gln Asp Arg Gly Tyr Ile Leu Arg Val Thr Ala
        1075                1080                1085            
Arg Lys Glu Gly Leu Gly Glu Gly Tyr Ile Thr Ile Thr Asp Glu Glu
    1090                1095                1100                
Gly Asn Thr Asp Gln Leu Thr Phe Gly Ser Cys Glu Glu Ile Asp Ala
1105                1110                1115               1120 
Ser Asn Ser Phe Val Ser Thr Gly Tyr Met Thr Lys Glu Leu Glu Phe
                1125                1130                1135    
Phe Pro Asp Thr Glu Lys Val Arg Ile Glu Ile Gly Glu Thr Glu Gly
            1140                1145                1150        
Thr Phe Lys Val Glu Ser Val Glu Leu Phe Leu Met Glu Asp Leu Cys
        1155                1160                1165            


<210> 46
<211> 1134
<212> PRT
<213> Bacillus thuringiensis

<400> 46
Met Met Asp Val Asn Lys Phe Tyr Gly Ser Arg Asn Val Asn Arg Met
 1               5                  10                  15      
Leu Asn Asn Pro Phe Asn Asn Ser Thr Gln Lys Glu Leu Leu Pro Val
            20                  25                  30          
Val Thr Gln Asn Pro Cys Val Asp Asn Pro Phe Val Asn Lys Ile Asn
        35                  40                  45              
Gln Thr Glu Met Leu Thr Asn Thr Ser Ile Ala Leu Asn Thr Val Ala
    50                  55                  60                  
Gly Val Thr Gly Ala Val Leu Gly Ser Leu Gly Val Pro Gly Ala Ser
65                  70                  75                  80  
Leu Ile Thr Ser Phe Tyr Gln Lys Val Leu Gly Leu Leu Trp Pro Thr
                85                  90                  95      
Asn Ser Arg Ala Glu Ile Trp Asp Ser Phe Ile Ser Val Val Glu Asp
            100                 105                 110         
Leu Ile Lys Lys Glu Val Glu Asn Tyr Ala Arg Glu Lys Ala Ile Thr
        115                 120                 125             
Glu Leu Glu Gly Leu Gly Asp Asn Met Lys Asp Tyr Lys Ser Lys Leu
    130                 135                 140                 
Gln Gln Trp Leu Asp Thr Pro Asn Asp Asp Thr Lys Arg Ser Leu Lys
145                 150                 155                 160 
His Tyr Met Glu Ser Leu Asp Met Asp Phe Lys Glu His Met Pro Gln
                165                 170                 175     
Phe Arg Ile Lys Gly Tyr Glu Val Gln Leu Leu Pro Val Phe Ala His
            180                 185                 190         
Ala Ala Asn Leu His Leu Ser Leu Phe Arg Asp Met Val Leu Tyr Gly
        195                 200                 205             
Pro Asp Leu Gly Phe Thr Pro Glu Asp Leu Ser Glu Asp Tyr Gln Gln
    210                 215                 220                 
Leu Gln Gln Arg Ile Ile Asp Tyr Thr Asn His Cys Asn Leu Tyr Phe
225                 230                 235                 240 
Glu Gln Gly Leu Ser Ser Leu Lys Lys Ser Ser Tyr Glu Glu Trp Val
                245                 250                 255     
Ile Tyr Asn Arg Phe Arg Arg Glu Met Thr Leu Met Val Leu Asp Ile
            260                 265                 270         
Ile Ala Gln Phe Pro Tyr Tyr Asp Val Lys Lys Tyr Pro Lys Pro Val
        275                 280                 285             
Ser Thr Gln Leu Thr Arg Glu Val Tyr Thr Asp Pro Leu Ile Thr Ser
    290                 295                 300                 
Phe Phe Gln Pro Gly Gln Gly Pro Asn Phe Ser Phe Met Glu Ser Asn
305                 310                 315                 320 
Ala Ile Arg Asn Pro His Leu Val Thr Tyr Leu Asp Ser Leu Tyr Ile
                325                 330                 335     
Tyr Thr Ala Lys Phe Arg Ala Tyr Ser Gln Glu Ile Gln Pro Asp Leu
            340                 345                 350         
Tyr Phe Trp Thr Ala His Lys Gly Lys Tyr Lys Leu Ser Ala Ser Thr
        355                 360                 365             
Asp Val His Asp Thr Ala Leu Tyr Gly Ser Thr Ser Gly Ser Ile Ser
    370                 375                 380                 
Glu Lys Asn Tyr Ser Phe Asn Gly Asn Asn Ile Tyr Gln Thr Leu Ala
385                 390                 395                 400 
Ala Pro Ser Ala Val Phe Thr Thr Ser Lys Gln Tyr Tyr Gly Ile Glu
                405                 410                 415     
Gln Val Glu Phe Tyr Gly Asp Lys Gly Lys Ile His Tyr Tyr Gly Asp
            420                 425                 430         
Arg Lys Tyr Pro Leu Ser Val Asp Ser Ala Asn Gln Leu Pro Pro Asp
        435                 440                 445             
Glu Glu Pro Ile Ser Glu Asn Tyr Asp His Ile Leu Thr His Ala Ser
    450                 455                 460                 
Ala Val Asn Val Leu Asp Gly Gly Thr Val Pro Ile Phe Ala Trp Thr
465                 470                 475                 480 
His Arg Ser Ala Asp Tyr Tyr Asn Thr Ile Tyr Ser Asp Lys Ile Thr
                485                 490                 495     
Gln Ile Pro Ala Val Lys Ile Asn Lys Leu Glu Asn Pro Ser Thr Val
            500                 505                 510         
Val Lys Gly Pro Gly Phe Thr Gly Gly Asp Leu Val Lys Arg Gly Ser
        515                 520                 525             
Thr Gly Ile Leu Gly Tyr Leu Asn Val Thr Val Asn Ser Pro Leu Ser
    530                 535                 540                 
Gln Arg Tyr Ala Val Lys Ile Arg Tyr Ala Ser Thr Ile Ser Gly Asp
545                 550                 555                 560 
Phe His Val Gln Ile Asp Gly Val Ala Thr Leu Glu Gly His Cys Glu
                565                 570                 575     
Ser Thr Ile Asn Ser Gly Asp Glu Leu Ser Phe Glu Ser Phe Ser Tyr
            580                 585                 590         
Lys Glu Phe Ser Thr Thr Val Gln Phe Thr Gly Asn Lys Pro Arg Leu
        595                 600                 605             
Arg Leu Ser Leu Asp Lys Val Ala Gly Thr Gly Val Phe Tyr Phe Asp
    610                 615                 620                 
Lys Ile Glu Phe Ile Pro Val Asp Val Asn Tyr Asp Glu Arg Val Gln
625                 630                 635                 640 
Leu Glu Lys Ala Gln Lys Ser Val Asn Ala Leu Phe Thr Ala Gly Arg
                645                 650                 655     
His Ala Leu Gln Thr Asp Val Thr Asp Phe Lys Val Asp Gln Val Ser
            660                 665                 670         
Ile Leu Val Asp Cys Val Ser Gly Glu Leu Tyr Pro Asn Glu Lys Arg
        675                 680                 685             
Glu Leu Leu Ser Leu Val Lys Tyr Ala Lys Arg Leu Ser Tyr Ser Arg
    690                 695                 700                 
Asn Leu Leu Leu Asp Pro Thr Phe Asp Ser Ile Asn Ser Ser Glu Glu
705                 710                 715                 720 
Asn Gly Trp His Gly Ser Asn Gly Ile Val Ile Gly Asn Gly Asn Phe
                725                 730                 735     
Val Phe Lys Gly Asn Tyr Leu Ile Phe Ser Gly Thr Asn Asp Thr Gln
            740                 745                 750         
Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Glu
        755                 760                 765             
Tyr Thr Arg Tyr Lys Leu Arg Gly Phe Ile Glu Asn Ser Gln Asp Leu
    770                 775                 780                 
Glu Ala Tyr Val Val Arg Tyr Asp Ala Lys His Glu Thr Leu Asp Val
785                 790                 795                 800 
Ser Asp Asn Leu Tyr Pro Asp Ile Ser Pro Val Asn Ala Cys Gly Glu
                805                 810                 815     
Pro Asn Arg Cys Ala Ala Leu Pro Tyr Leu Asp Glu Asn Pro Arg Leu
            820                 825                 830         
Glu Cys Ser Ser Ile Gln Asp Gly Ile Leu Ser Asp Ser His Ser Phe
        835                 840                 845             
Ser Leu Asn Ile Asp Thr Gly Ser Ile Asp Ser Asn Glu Asn Val Gly
    850                 855                 860                 
Ile Trp Val Leu Phe Lys Ile Ser Thr Pro Glu Gly Tyr Ala Lys Phe
865                 870                 875                 880 
Gly Asn Leu Glu Val Ile Glu Asp Gly Pro Val Ile Gly Glu Ala Leu
                885                 890                 895     
Ala Arg Val Lys Arg Gln Glu Thr Lys Trp Arg Asn Lys Leu Ala Gln
            900                 905                 910         
Leu Arg Thr Glu Thr Gln Ala Ile Tyr Thr Arg Ala Lys Gln Ala Ile
        915                 920                 925             
Asp Asn Leu Phe Thr Asn Ala Gln Asp Ser His Leu Lys Ile Gly Ala
    930                 935                 940                 
Thr Phe Ala Ser Ile Val Ala Ala Arg Lys Ile Val Gln Ser Ile Arg
945                 950                 955                 960 
Glu Ala Tyr Met Ser Trp Leu Ser Ile Val Pro Gly Val Asn Tyr Pro
                965                 970                 975     
Ile Phe Thr Glu Leu Asn Glu Arg Val Gln Gln Ala Phe Gln Leu Tyr
            980                 985                 990         
Asp Val Arg Asn Val Val Arg Asn Gly Arg Phe Leu Asn Gly Val Ser
        995                 1000                1005            
Asp Trp Ile Val Thr Ser Asp Val Lys Val Gln Glu Glu Asn Gly Asn
    1010                1015                1020                
Asn Val Leu Val Leu Ser Asn Trp Asp Ala Gln Val Leu Gln Cys Leu
1025                1030                1035               1040 
Lys Leu Tyr Gln Asp Arg Gly Tyr Ile Leu Arg Val Thr Ala Arg Lys
                1045                1050                1055    
Glu Gly Leu Gly Glu Gly Tyr Ile Thr Ile Thr Asp Glu Ala Gly His
            1060                1065                1070        
Thr Asp Gln Leu Thr Phe Gly Thr Cys Glu Glu Ile Asp Ala Ser Asn
        1075                1080                1085            
Thr Phe Val Ser Thr Gly Tyr Met Thr Lys Glu Leu Glu Phe Phe Pro
    1090                1095                1100                
Asp Thr Glu Lys Val Arg Ile Glu Ile Gly Glu Thr Glu Gly Ile Phe
1105                1110                1115               1120 
Gln Val Glu Ser Val Glu Leu Phe Leu Met Glu Asp Leu Cys
                1125                1130                


<210> 47
<211> 1144
<212> PRT
<213> Bacillus thuringiensis

<400> 47
Met Asp Gln Gln Asn Glu Tyr Glu Ile Ile Gln Ala Gly Val Ser Asn
 1               5                  10                  15      
Ala Ile Thr Asp Thr Phe Gln Arg Tyr Pro Leu Ala Asn Asn Pro Asn
            20                  25                  30          
Thr Ser Phe Gln Asn Met Asn Tyr Lys Asp Tyr Leu Asn Asp Pro Met
        35                  40                  45              
Phe Leu Gly Glu Thr Arg Asp Ala Gln Thr Ala Ile Thr Thr Ser Leu
    50                  55                  60                  
Glu Ile Ile Ser Glu Ile Leu Gly Phe Leu Gly Val Pro Phe Val Gly
65                  70                  75                  80  
Pro Ile Ile Gly Phe Thr Asn Arg Leu Ile Asn Leu Leu Trp Pro Arg
                85                  90                  95      
Asn Thr Thr Asp Ile Trp Asn Ala Phe Met Asp Glu Val Gln Ala Leu
            100                 105                 110         
Ile Asn Glu Ser Ile Thr Lys Ala Val Arg Ser Lys Ala Ile Ser Glu
        115                 120                 125             
Leu Glu Gly Ile His Gln Val Tyr Arg Leu Tyr Ile Glu Ala Leu Asn
    130                 135                 140                 
Glu Trp Lys Asp Thr Pro Asp Asn Pro Phe Val Gln Glu Arg Val Arg
145                 150                 155                 160 
Thr Thr Phe Arg Asp Val Asn Ser Ile Ile Asn Tyr Ala Met Pro Ser
                165                 170                 175     
Phe Arg Val Gln Gly Phe Glu Ile Pro Leu Leu Val Val Tyr Ala Gln
            180                 185                 190         
Ala Ala Asn Leu His Leu Val Leu Leu Arg Asp Ala Thr Leu Phe Gly
        195                 200                 205             
Ala Gly Trp Gly Phe Thr Glu Thr Asn Ile Asn Asp Arg Tyr Asn Glu
    210                 215                 220                 
Gln Val Arg Val Thr Asn Gly Tyr Ile Asp His Cys Thr Lys Trp Tyr
225                 230                 235                 240 
Asn Glu Gly Leu Thr Arg Leu Lys Asn Asn Trp Ser Lys Tyr His Gln
                245                 250                 255     
Phe Arg Arg Glu Met Thr Leu Met Val Leu Asp Leu Ile Ala Leu Phe
            260                 265                 270         
Pro Ser His Asp Ala Arg Arg Tyr Pro Met Glu Thr Ser Ala Gln Leu
        275                 280                 285             
Thr Arg Asp Val Tyr Thr Asp Pro Ile Gly Tyr Arg Gly Asn Ala Asn
    290                 295                 300                 
Phe Ser Asp Pro Trp Thr Asn His Val Ser Phe Ser Lys Ala Glu Ser
305                 310                 315                 320 
Glu Thr Ile Arg Pro Pro His Leu Phe Asp Thr Leu Glu Ser Val Glu
                325                 330                 335     
Ile Asn Thr Ala Lys Ala Met Leu Pro Leu Asn Asp Lys Ser Tyr Met
            340                 345                 350         
Tyr Tyr Trp Ala Gly His Thr Val Thr Ser Arg Leu Leu Asp Ser Ser
        355                 360                 365             
Gly Asn Pro Leu Lys Tyr Thr Tyr Gly Ser Met Thr Ser Glu Lys Asn
    370                 375                 380                 
Leu Val Ser Leu Pro Gly Lys Asp Val Tyr Arg Ile Asn Ser Val Ala
385                 390                 395                 400 
Ser Gly Phe Ser Asn Tyr Tyr Ala Lys Leu Tyr Gly Val Ser Lys Val
                405                 410                 415     
Asp Phe Ser Ile Val Asp Arg Asn Asn Ser Asn Lys Thr Thr Tyr Ser
            420                 425                 430         
Tyr Ser Lys Ser Ser Thr Val Pro Ser Asp Asn Lys Glu Asn Arg Asp
        435                 440                 445             
Ser Glu Asn Glu Leu Pro Gln Thr Thr Thr Asp Gln Pro Asp Tyr Lys
    450                 455                 460                 
Gly Tyr Ser His Arg Leu Ser His Ile Thr Phe Ile Ser Ser Ala Ile
465                 470                 475                 480 
Pro Thr Tyr Val Trp Thr Arg Lys Ser Ala Asp Leu Thr Asn Thr Ile
                485                 490                 495     
Tyr Pro Asp Lys Ile Thr Gln Ile Pro Ala Val Lys Met Tyr Glu Leu
            500                 505                 510         
Gly Ser Ser Ala Val Val Val Lys Gly Pro Gly Phe Thr Gly Gly Asp
        515                 520                 525             
Leu Val Lys Arg Thr Asn Asn Gly Ser Leu Gly Arg Phe Lys Ile Thr
    530                 535                 540                 
Ile Asp Ser Pro Gly Ala His Arg Tyr Arg Leu Arg Val Arg Tyr His
545                 550                 555                 560 
Ser Asp Val Ser Gly Val Phe His Met Gln Ile Asn Asn Val Glu Thr
                565                 570                 575     
Ile Gln Gly Glu Phe Lys Ser Thr Val Asp Ser Thr Ser Thr Met Ser
            580                 585                 590         
Asn Asp Ser Phe Gln Leu Arg Glu Phe Thr Thr Thr Phe Arg Phe Pro
        595                 600                 605             
Ser Asn Val Thr Asp Ile Lys Val Ser Leu Gly Ala Ile Asn Gly Gln
    610                 615                 620                 
Gly Asn Phe Tyr Leu Asp Arg Ile Glu Phe Ala Pro Val Asp Thr Asn
625                 630                 635                 640 
Tyr Asp Glu Arg Ile Thr Leu Glu Lys Ala Gln Lys Ala Val Asn Ala
                645                 650                 655     
Leu Phe Thr Glu Gly Arg Asn Ala Leu Gln Thr Asp Met Thr Asp Tyr
            660                 665                 670         
Lys Val Asp Gln Val Ser Ile Leu Val Asp Cys Val Ser Gly Glu Val
        675                 680                 685             
Tyr Pro Asn Glu Lys Arg Glu Leu Leu Asn Leu Val Lys Tyr Ala Lys
    690                 695                 700                 
Arg Leu Ser Ile Ala Arg Asn Leu Leu Val Asp Pro Asn Phe Thr Ser
705                 710                 715                 720 
Ile His Ala Ser Met Tyr Ser Glu Asp Val Lys Gly Trp Tyr Gly Ser
                725                 730                 735     
Asn Gly Ile Ala Thr Gly Ser Gly Asp Val Val Leu Lys Glu Asn Tyr
            740                 745                 750         
Val Ser Leu Pro Ser Thr Ser Asp Ala Gln Tyr Pro Thr Tyr Leu Tyr
        755                 760                 765             
Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg Tyr Lys Leu
    770                 775                 780                 
Arg Gly Phe Ile Glu Asn Ser Gln Asp Leu Glu Ala Tyr Val Val Arg
785                 790                 795                 800 
Tyr Asp Ala Lys His Glu Thr Leu Asp Val Ser Asn Asn Leu Leu Pro
                805                 810                 815     
Asp Val Leu Pro Val Asn Ala Cys Gly Glu Pro Asp Arg Cys Ala Ala
            820                 825                 830         
Leu Gln Tyr Leu Asp Glu Asn Pro Arg Leu Glu Cys Ser Ser Ile Gln
        835                 840                 845             
Asp Gly Ile Leu Ser Asp Ser His Ser Phe Ser Leu Asn Ile Asp Thr
    850                 855                 860                 
Gly Ser Met Asp Leu Asn Glu Asn Leu Gly Ile Trp Val Leu Phe Lys
865                 870                 875                 880 
Ile Ser Thr Pro Glu Gly Tyr Ala Lys Phe Gly Asn Leu Glu Val Ile
                885                 890                 895     
Glu Asp Gly Thr Val Ser Gly Glu Ala Leu Ala Arg Val Lys Arg Gln
            900                 905                 910         
Glu Thr Lys Trp Arg Asn Lys Leu Ala Gln Leu Arg Thr Glu Thr Gln
        915                 920                 925             
Ala Ile Tyr Thr Arg Ala Lys Gln Ala Leu Asp Asn Leu Phe Thr Asp
    930                 935                 940                 
Ala Gln Asp Ser Tyr Leu Lys Ile Gly Ala Thr Phe Ala Ala Ile Val
945                 950                 955                 960 
Ala Ala Arg Lys Ile Val Gln Ser Ile Arg Glu Ala Tyr Met Ser Trp
                965                 970                 975     
Leu Ser Val Val Pro Gly Val Asn Tyr Pro Ile Phe Thr Glu Leu Asn
            980                 985                 990         
Glu Arg Val Gln Arg Ala Phe Gln Leu Tyr Asp Gly Arg Asn Val Val
        995                 1000                1005            
Arg Asn Gly Arg Phe Leu Asn Gly Val Leu Asp Trp Ile Val Thr Ser
    1010                1015                1020                
Asp Val Ser Val Gln Glu Glu Asn Gly Asn Asn Val Leu Val Leu Ser
1025                1030                1035               1040 
Asn Trp Asp Ala Gln Val Leu Gln Cys Leu Lys Leu Tyr Gln Asp Arg
                1045                1050                1055    
Gly Tyr Ile Leu Arg Val Thr Ala Arg Lys Glu Gly Leu Gly Glu Gly
            1060                1065                1070        
Tyr Ile Thr Ile Thr Asp Glu Glu Gly Asn Thr Asp Gln Leu Thr Phe
        1075                1080                1085            
Gly Ser Cys Glu Glu Ile Asp Thr Ser Asn Ser Phe Val Ser Thr Gly
    1090                1095                1100                
Tyr Met Thr Lys Glu Leu Glu Phe Phe Pro Asp Thr Glu Lys Val Arg
1105                1110                1115               1120 
Ile Glu Ile Glu Glu Thr Glu Gly Thr Phe Lys Val Glu Ser Val Glu
                1125                1130                1135    
Leu Phe Leu Met Glu Asp Leu Cys
            1140                


<210> 48
<211> 1196
<212> PRT
<213> Bacillus thuringiensis

<400> 48
Met Ser Pro Asn Asn Gln Asn Glu Tyr Glu Ile Ile Asp Thr Pro Ser
 1               5                  10                  15      
Ser Asn Ser Leu Asp Asn Gln Phe Val Arg Tyr Pro Leu Ala Lys Glu
            20                  25                  30          
Pro Thr Gln Val Arg Gln Asn Leu Asn Tyr Lys Asp Trp Leu Asn Ser
        35                  40                  45              
Leu Asp Glu Asn Asn Asn Gln Ser Phe Gly Val Thr Pro Arg Arg Ala
    50                  55                  60                  
Ser Val Val Gly Ala Val Gly Ser Ile Leu Gly Ala Thr Leu Gly Thr
65                  70                  75                  80  
Ile Pro Tyr Val Gly Asp Ile Leu Ala Leu Ile Val Gly Ile Phe Trp
                85                  90                  95      
Pro Glu Gly Ser Asp Pro Glu Asp Tyr Ser Glu Leu Ile Asn Ala Ile
            100                 105                 110         
Met Glu Gln Val Glu Leu Leu Ile Asp Gln Lys Ile Ser Glu Gln Val
        115                 120                 125             
Arg Asn Asp Ala Leu Ala Thr Leu Glu Ser Ser Gly Ile Ala Leu Gln
    130                 135                 140                 
Ala Tyr Leu Asn Ala Leu Glu Asp Trp Lys Ile Asn Pro Asn Asn Ala
145                 150                 155                 160 
Arg Ser Thr Gln Leu Val Arg Glu Arg Phe Thr Phe Ala Glu Ala Gln
                165                 170                 175     
Val Arg Thr Asn Ile Ala Tyr Val Ser Arg Lys Asp Tyr Glu Ile Leu
            180                 185                 190         
Leu Leu Pro Ile Tyr Ala Gln Val Ala Asn Ile His Leu Leu Leu Leu
        195                 200                 205             
Lys Gln Val Gln Leu Tyr Gly Thr Lys Leu Gly Tyr Thr Gln Asn Asp
    210                 215                 220                 
Ile Asp Leu Ile Tyr Glu Glu Gln Lys Lys Phe Thr Ala Gln Tyr Thr
225                 230                 235                 240 
Asn His Cys Thr Asn Trp Tyr Asn Ile Gly Leu Asn Asn Ile Trp Glu
                245                 250                 255     
Ser Ile Ala Gly Thr Ser Tyr Ser Gly Ser Arg Trp Asp Glu Phe Asn
            260                 265                 270         
Asp Phe Arg Arg Asp Leu Thr Leu Thr Val Leu Asp Ile Val Ser Thr
        275                 280                 285             
Phe Pro Ile His Asp Thr Arg Leu Tyr Pro Glu Lys Val Asn Gly Gln
    290                 295                 300                 
Leu Thr Arg Glu Ile Tyr Thr Arg Ser Ile Asn Val Asn Tyr Phe Asn
305                 310                 315                 320 
Gln Val Ser Ala Arg Thr Ile Glu Asp Ala Glu Arg Leu Leu Thr Asn
                325                 330                 335     
Pro Pro Arg Leu Leu Pro Trp Ile Glu Gln Leu Glu Phe Asn Thr Asn
            340                 345                 350         
Val Asn Phe Ser Val Asn Trp Lys Phe Leu Thr Ser Thr Arg Arg Arg
        355                 360                 365             
Phe Ile Tyr Thr Asn Ser Ser Asp Leu Asn Tyr Asp Gly Tyr Ala Gly
    370                 375                 380                 
Tyr His Leu Asp Gly Thr Ser Asn Ser Phe Leu Tyr Pro Ser Asn Asn
385                 390                 395                 400 
Glu Arg Ile Tyr Thr Ile Thr Ala Gln Arg Phe Gly Glu Gln Arg Asn
                405                 410                 415     
Ile Pro Gln Ala Ile Thr Gly Leu Thr Phe Ser Met Asn Thr Gly Arg
            420                 425                 430         
Thr Tyr Arg Tyr Ser Ser Asn Thr Pro Ala Gly Pro Ser Ile Ile Thr
        435                 440                 445             
Glu Asp Tyr His Leu Pro Gly Leu Asn Gly Glu Glu Val Pro Asn Ser
    450                 455                 460                 
Asn Asn Phe Ser His Phe Leu Arg Ser Ile Asn Gly Tyr Ser Asn Gly
465                 470                 475                 480 
Asn Gln Arg Ile Phe His Ser Phe Gly Trp Thr His Ala Ser Val Asp
                485                 490                 495     
Phe Glu Asn Lys Ile Tyr Pro Thr Ile Ile Thr Gln Ile Pro Ala Val
            500                 505                 510         
Lys Ala Ile Gln Gly Thr Met Pro Tyr Pro Val Val Lys Gly Pro Gly
        515                 520                 525             
Phe Thr Gly Gly Asp Ile Ala Arg Leu Pro Asn Asn Pro Thr Leu Gly
    530                 535                 540                 
Leu Trp Phe Asn Gly Thr Met Glu Ser Leu Gly Ser Gly His Asp Pro
545                 550                 555                 560 
Ala Pro Arg Tyr Arg Val Arg Ile Arg Tyr Ala Ser Gln Ser Gly Gly
                565                 570                 575     
Ser Ala Asn Phe Arg Phe Met Ser Ser Asn Gly Gln Asn Ser Ser Gln
            580                 585                 590         
Gln Asn Phe Ser Phe Thr Ser Thr Met Thr Thr Gly Glu Pro Ser Lys
        595                 600                 605             
Tyr Glu Asp Phe Arg Phe Ser Val Leu Pro Asn Ile Val Thr Pro Leu
    610                 615                 620                 
Ser Phe Asn Val Ser Trp His Leu Val Ala Ser Asn Ala Asn Pro Asn
625                 630                 635                 640 
Asn Asn Val Tyr Ile Asp Arg Ile Glu Phe Ile Pro Glu Phe Leu Met
                645                 650                 655     
Ala Arg Ser Asp Leu Glu Thr Ala Lys Lys Ala Val Asn Glu Leu Phe
            660                 665                 670         
Thr Asn Thr Lys Asn Ser Leu Arg Arg Glu Val Thr Asp Tyr Gln Val
        675                 680                 685             
Ser Gln Ala Val Ser Leu Val Glu Cys Leu Ser Asp Glu Leu Tyr Pro
    690                 695                 700                 
Asn Glu Lys Arg Met Leu Ile Asp Ala Val Lys Glu Ala Lys Arg Leu
705                 710                 715                 720 
Ser Glu Ala Arg Asn Leu Leu Glu Asp Ile Asp Leu Lys Val Ile Ser
                725                 730                 735     
Glu Tyr Gly Glu Asp Gly Trp Ile Gly Ser Lys Gly Ile Glu Val Ala
            740                 745                 750         
Lys Ser Asn Pro Leu Tyr Lys Asn Asp Leu Leu Arg Leu Pro Lys Val
        755                 760                 765             
Arg Glu Ile Glu Gly Glu Ile Tyr Pro Thr Tyr Leu Tyr Tyr Lys Val
    770                 775                 780                 
Asp Glu Ser Leu Leu Lys Pro Tyr Thr Arg Tyr Lys Phe Arg Gly Phe
785                 790                 795                 800 
Ile Glu Ser Ser Arg Asp Leu Glu Ile Phe Val Ile Arg His Gln Ala
                805                 810                 815     
Tyr Arg Val Val Lys Asn Val Pro Ser Asn Leu Leu Ser Asp Ile Gly
            820                 825                 830         
Pro Val Asn Ala Cys Gly Gly Phe Asp Arg Cys Ser Glu Gln Lys Tyr
        835                 840                 845             
Val Asn Ser Met Leu Glu Leu Asp Asn Asp Leu Ser Asn Glu Asn Arg
    850                 855                 860                 
Ser Ser Glu Ala His Glu Phe Ser Ile His Val Asp Thr Gly Glu Leu
865                 870                 875                 880 
Asn Tyr Ser Glu Asn Pro Gly Ile Trp Val Ala Phe Lys Ile Thr Lys
                885                 890                 895     
Met Asp Gly Tyr Ala Thr Val Gly Asn Leu Glu Leu Val Glu Val Glu
            900                 905                 910         
Thr Leu Ser Gly Glu Ala Leu Glu Arg Val Gln Arg Gln Glu Lys Gln
        915                 920                 925             
Trp Gln Gly Gln Leu Ala Thr Arg Arg Lys Glu Thr Glu Thr Arg Tyr
    930                 935                 940                 
Gly Pro Ala Lys Gln Ala Ile Asp Arg Leu Phe Val Asp Tyr Gln Asp
945                 950                 955                 960 
Arg Gln Leu Tyr Ser Gly Thr Lys Ile Ser Asp Leu Ile Ala Ala Gln
                965                 970                 975     
Asn Leu Val Gln Ser Ile Pro Tyr Val Tyr Asn Asp Met Leu Pro Glu
            980                 985                 990         
Ile Pro Gly Met Asn Tyr Thr Ser Val Thr Glu Leu Thr Asn Arg Leu
        995                 1000                1005            
Gln Gln Ala Trp Asn Leu Tyr Asp Gln Arg Asn Ser Ile Gln Asn Gly
    1010                1015                1020                
Asp Phe Arg Lys Asp Ile Asn Asn Trp Asn Val Thr Asn Gly Val Asn
1025                1030                1035               1040 
Ile Gln Gln Met Asn Asp Thr Ser Val Leu Val Ile Pro Asn Trp Asp
                1045                1050                1055    
Ser Gln Val Ser Gln Gln Ile Thr Val Gln Pro Asn Arg Arg Tyr Val
            1060                1065                1070        
Leu Arg Val Thr Ala Arg Lys Glu Gly Ser Gly Asp Gly Tyr Val Thr
        1075                1080                1085            
Ile Arg Asp Gly Ala Lys Tyr Thr Glu Thr Leu Thr Phe Asn Thr Cys
    1090                1095                1100                
Asp Tyr Asn Gly Ser Asn Val Tyr Gln Glu Gln Ala Leu Tyr Thr Asn
1105                1110                1115               1120 
Asp Val Tyr Asn Thr Gln Ser Ala Asn Ile His Gly Ser Asn Ser Ala
                1125                1130                1135    
Tyr His Thr Gln Ala Ser Asn Thr Asp Arg Tyr Asn Met Asn Gly Met
            1140                1145                1150        
Tyr Asn Asp Gln Thr Ser Tyr Val Thr Lys Thr Val Glu Phe Ile Pro
        1155                1160                1165            
Asn Thr Glu Gln Val Trp Ile Glu Met Ser Glu Thr Glu Gly Val Phe
    1170                1175                1180                
Tyr Ile Glu Ser Val Glu Leu Ile Val Glu Glu Asn
1185                1190                1195    


<210> 49
<211> 1226
<212> PRT
<213> Bacillus thuringiensis

<400> 49
Met Lys Asn Val Trp Lys Val Ile Leu Cys Ser Lys Cys Ile Gly Gly
 1               5                  10                  15      
Lys Lys Met Ser Pro Asn Asn Gln Asn Glu Phe Asp Ile Ile Asp Val
            20                  25                  30          
Pro Ser Asn Thr Ser Ile Ser Thr Asn Phe Val Arg Tyr Pro Phe Val
        35                  40                  45              
Asn Asp Pro Asn Ser Asn Thr Leu Gln Asn Lys Asn Tyr Lys Asp Phe
    50                  55                  60                  
Leu Thr Met Ser Glu Lys Ser Asn Ser Gly Tyr Leu Thr Asp Pro Glu
65                  70                  75                  80  
Ala Phe Asp Asp Val Gly Ser Ala Ile Phe Ala Gly Leu Ser Ile Thr
                85                  90                  95      
Ala Lys Ile Met Asp Ala Phe Asp Val Pro Gly Gly Asp Ile Phe Asn
            100                 105                 110         
Gly Leu Leu Glu Ile Ile Gly Ile Leu Trp Asp Leu Gln Asp Asp Thr
        115                 120                 125             
Trp Glu Ala Phe Met Glu Gln Val Glu Val Leu Ile Asp Gln Lys Ile
    130                 135                 140                 
Ala Glu Tyr Ala Arg Asn Leu Ala Leu Thr Asn Leu Lys Gly Leu Glu
145                 150                 155                 160 
Asn Ser Tyr Lys Leu Tyr Leu Glu Ala Leu Ala Asp Trp Lys Gln Asn
                165                 170                 175     
Pro Thr Ser Pro Ser Ser Gln Glu Arg Val Arg Thr Arg Phe Arg Asp
            180                 185                 190         
Thr Asp Asp Ser Leu Thr Val Phe Met Pro Ser Phe Ala Val Lys Gly
        195                 200                 205             
Tyr Glu Ile Pro Leu Leu Ala Val Tyr Ala Gln Ala Ala Asn Leu His
    210                 215                 220                 
Leu Leu Leu Leu Arg Asp Ser Ala Ala Tyr Gly Leu Gly Trp Gly Leu
225                 230                 235                 240 
Ser Gln Leu Asn Val Asn Asp Asn Tyr Asn Arg Gln Val Arg Leu Thr
                245                 250                 255     
Gly Glu Tyr Thr Asn His Cys Val Ser Trp Tyr Thr Thr Gly Leu Glu
            260                 265                 270         
Lys Leu Arg Gly Ser Asn Ala Gln Ser Trp Ile Lys Phe Asn Arg Tyr
        275                 280                 285             
Arg Arg Glu Met Thr Val Met Val Leu Asp Ile Val Ala Leu Phe Pro
    290                 295                 300                 
Asn Tyr Asp Ala Arg Arg Tyr Pro Gln Ala Thr Thr Thr Glu Leu Thr
305                 310                 315                 320 
Arg Leu Ile Tyr Thr Asp Pro His Gly Tyr Thr Ile Tyr Ser Pro Thr
                325                 330                 335     
Ser Gln Thr Thr Ile Pro Trp Tyr Glu Tyr Gly Gln Ser Phe Ser Glu
            340                 345                 350         
Ile Glu Asn Val Ala Ile Gln Ala Pro Arg Leu Phe Arg Trp Ala Gln
        355                 360                 365             
Lys Leu Gln Ile Tyr Ser Lys Phe Val Arg His Ala Pro Gln Glu Ser
    370                 375                 380                 
His Tyr Trp Ser Gly His Thr Phe Thr Phe His His Thr Arg Asp Asp
385                 390                 395                 400 
Thr Lys Thr Ser Leu Thr Tyr Gly Asp Ile Ile Asp Tyr Lys Tyr Leu
                405                 410                 415     
Ser Glu Ala Asp Leu Ser Asn Thr Asp Ile Tyr Lys Val Ser Ser Leu
            420                 425                 430         
Val Ala Ser Ser Trp Gly Ser Gly Val Arg Leu Leu Val Thr Lys Ala
        435                 440                 445             
Ile Phe Glu Thr Ile Asn Thr Ser Asn Lys Leu Ile Asp Tyr Glu Tyr
    450                 455                 460                 
Asp Leu Gln Leu Leu Ser Asn Phe Phe Asn Glu Trp Lys Asn Thr Glu
465                 470                 475                 480 
Ala Glu Leu Pro Ile Gln Ile Val Asn Pro Pro Ile Phe Gly Asp Phe
                485                 490                 495     
Asn Gln Tyr Ser His Arg Val Ala Tyr Ile Ser His Ala Pro Ile Gln
            500                 505                 510         
Pro Tyr Ser Gly Ala Phe Arg Asn Tyr Gly Leu Val Pro Val Tyr Gly
        515                 520                 525             
Trp Ser His Val Ser Val Asp Arg Asn Asn Thr Ile Tyr Ala Asp Arg
    530                 535                 540                 
Ile Ser Gln Ile Pro Ala Val Lys Ala Val Gln Gly Ser Gly Glu Pro
545                 550                 555                 560 
Tyr Pro Val Val Arg Gly Pro Gly Phe Thr Gly Gly Asp Ile Ala Arg
                565                 570                 575     
Leu Pro Asn Asn Pro Asn Val Gly Leu Trp Phe Asn Ser Lys Val Glu
            580                 585                 590         
Ser Thr Ala Leu Asn Lys Arg Phe Arg Val Arg Ile Arg Tyr Ala Cys
        595                 600                 605             
Ala Thr Gly Ala Arg Ala Asp Phe Gly Gly Leu Thr Leu Pro Ile Thr
    610                 615                 620                 
Val Gln Phe Asn Gln Thr Met Ser Thr Thr Thr Pro Thr Arg Tyr Glu
625                 630                 635                 640 
Asp Phe Gln Tyr Val Asp Ile Ser Gly Ser Phe Leu Leu Thr Asn Thr
                645                 650                 655     
Asn Ser Gly Phe Ser Leu Val Ala Gln Ser Ala Asn Gln Thr Asn Asn
            660                 665                 670         
Leu Phe Ile Asp Lys Ile Glu Phe Ile Pro Glu Asn Pro Ala Leu Glu
        675                 680                 685             
Ala Glu Ser Asp Leu Glu Ala Ala Lys Lys Ala Val Asn Ala Leu Phe
    690                 695                 700                 
Thr Asn Arg Lys Asn Val Leu Gln Thr Gly Val Thr Asp Tyr Gln Ile
705                 710                 715                 720 
Asn Gln Ala Ala Asn Leu Ile Glu Cys Val Ser Asp Glu Val Tyr Pro
                725                 730                 735     
Asn Glu Lys Arg Leu Leu Phe Asp Ala Val Lys Glu Ala Lys Arg Leu
            740                 745                 750         
Ser Ala Thr Arg Asn Leu Leu Glu Asp Thr Asp Phe His Ala Ile Asn
        755                 760                 765             
Gly Gly Asn Gly Trp Thr Gly Ser Thr Gly Ile Glu Ile Val Glu Gly
    770                 775                 780                 
Asp Ile Leu Phe Lys Asp Arg Ser Leu Arg Leu Pro Ser Ala Arg Glu
785                 790                 795                 800 
Thr Asp Arg Glu Ile Tyr Pro Thr Tyr Ile Tyr Gln Lys Ile Asp Glu
                805                 810                 815     
Ser Arg Leu Lys Gln Asn Thr Arg Tyr Ser Leu Arg Gly Phe Ile Gly
            820                 825                 830         
Ser Ser Gln Asp Leu Glu Ile Tyr Val Leu Arg His Gln Ala Tyr Arg
        835                 840                 845             
Val Ile Lys Asn Val Ser Asp Asn Leu Leu Pro Asn Ile Arg Pro Ile
    850                 855                 860                 
Asn Ala Cys Gly Gly Val Asp Arg Cys Ser Gln Gln Lys Tyr Val Asn
865                 870                 875                 880 
Asn Ser Leu Glu Val Asn Ser Gly Leu Ser Asn Gly Ile Gly Ala Ser
                885                 890                 895     
Asp Ser His Glu Phe Ser Ile His Val Asp Thr Gly Glu Leu Asn Tyr
            900                 905                 910         
Asn Glu Asn Thr Gly Ile Trp Val Val Phe Lys Ile Ala Thr Thr Asn
        915                 920                 925             
Gly Tyr Ala Thr Leu Gly Asn Leu Glu Leu Val Glu Glu Gly Pro Leu
    930                 935                 940                 
Ser Gly Asp Ala Leu Glu Arg Val Lys Asn Gln Glu Lys Gln Trp Gln
945                 950                 955                 960 
Asp Gln Met Thr Arg Arg Arg Ala Glu Thr Glu Asn Arg Tyr Gly Leu
                965                 970                 975     
Ala Lys Gln Ala Val Asp Arg Leu Phe Val Asp Tyr Gln Asp Gln Gln
            980                 985                 990         
Val Ser Pro Ile Ile Glu Ile Ser Asp Leu Thr Ala Ala Gln Asn Val
        995                 1000                1005            
Val Gln Ser Ile Pro Tyr Val Tyr Asn Asp Met Leu Pro Glu Ile Pro
    1010                1015                1020                
Gly Met Asn Tyr Thr Ser Val Thr Glu Leu Thr Asn Arg Leu Gln Gln
1025                1030                1035               1040 
Ala Trp Asp Leu Tyr Asp Gln Arg Asn Ser Ile Gln Asn Gly Asp Phe
                1045                1050                1055    
Arg Asn Asp Val Ser Asn Trp Asn Val Thr Pro Glu Val Asn Ile Gln
            1060                1065                1070        
Gln Met Asn Asp Thr Ser Val Leu Val Ile Pro Asn Trp Asp Ser Gln
        1075                1080                1085            
Ala Ser Gln Gln Ile Thr Val Gln Pro Asn Arg Arg Tyr Val Leu Arg
    1090                1095                1100                
Val Thr Ala Arg Lys Glu Gly Ser Gly Asp Gly Tyr Val Thr Ile Arg
1105                1110                1115               1120 
Asp Gly Ala Lys Tyr Thr Glu Thr Leu Thr Phe Asn Thr Cys Asp Tyr
                1125                1130                1135    
Asn Gly Ser Ser Val Tyr Gln Glu Gln Ala Leu Tyr Thr Asn Asp Val
            1140                1145                1150        
Tyr Asn Thr Gln Ser Ala Asn Ile His Gly Ser Asn Ser Ala Tyr His
        1155                1160                1165            
Thr Gln Ala Ser Asn Thr Asp Arg Tyr Asn Met Asn Gly Met Tyr Asn
    1170                1175                1180                
Asp Gln Thr Ser Tyr Val Thr Lys Thr Val Glu Phe Ile Pro Asn Thr
1185                1190                1195               1200 
Glu Gln Val Trp Ile Glu Met Ser Glu Thr Glu Gly Val Phe Tyr Ile
                1205                1210                1215    
Glu Ser Val Glu Leu Ile Val Glu Glu Asn
            1220                1225    


<210> 50
<211> 1169
<212> PRT
<213> Bacillus thuringiensis

<400> 50
Met Ser Pro Asn Asn Gln Asn Glu Tyr Glu Ile Ile Asp Ala Thr Pro
 1               5                  10                  15      
Ser Thr Ser Val Ser Asn Asp Ser Thr Lys Tyr Pro Tyr Ala Asn Glu
            20                  25                  30          
Pro Thr Asn Ala Leu Gln Asn Met Asn Tyr Lys Asp Tyr Leu Arg Met
        35                  40                  45              
Ser Glu Gly Tyr Asp Asn Lys Tyr Phe Ala Asn Pro Glu Val Phe Ala
    50                  55                  60                  
Ala Pro Gly Gly Ile Thr Thr Gly Ile Thr Ile Val Thr Lys Leu Leu
65                  70                  75                  80  
Gly Trp Leu Gly Leu Pro Phe Ala Gly Glu Thr Gly Met Ala Leu Asn
                85                  90                  95      
Phe Ile Leu Gly Leu Leu Trp Pro Thr Ser Gly Asn Pro Trp Ala Glu
            100                 105                 110         
Leu Met Ile Leu Val Glu Glu Leu Ile Asn Gln Lys Ile Glu Glu Ala
        115                 120                 125             
Val Arg Asn Lys Ala Leu Ala Asp Leu Ala Asn Ser Gly Arg Ala Leu
    130                 135                 140                 
Gln Ser Tyr Leu Asn Ala Phe Glu Asp Trp Gln Lys Asn Pro Asn Ile
145                 150                 155                 160 
Phe Arg Ser Lys Glu Leu Val Arg Glu Arg Phe Ala Asn Ala Glu His
                165                 170                 175     
Ser Leu Arg Thr Glu Met Ser Ser Phe Ala Ile Arg Gly Phe Glu Ile
            180                 185                 190         
Pro Leu Leu Ala Thr Tyr Ala Gln Ala Ala Asn Leu His Leu Phe Leu
        195                 200                 205             
Ile Lys Asp Val Gln Ile Tyr Gly Lys Glu Trp Gly Tyr Thr Gln Ala
    210                 215                 220                 
Asp Ile Asp Leu Phe Tyr Arg Glu Gln Val Glu Phe Thr Lys Glu Tyr
225                 230                 235                 240 
Thr Glu His Cys Ile Asn Ile Tyr Asn Asp Gly Leu Asn Gln Leu Lys
                245                 250                 255     
Gly Ser Asn Ala Lys Gln Trp Ile Ala Phe Asn Arg Phe Arg Arg Glu
            260                 265                 270         
Met Thr Leu Thr Val Leu Asp Val Val Ala Leu Phe Ser Asn Tyr Asp
        275                 280                 285             
Val Arg Met Tyr Pro Ile Lys Thr Thr Thr Glu Leu Thr Arg Thr Ile
    290                 295                 300                 
Tyr Thr Asp Pro Leu Gly Tyr Thr Lys Thr Gly Ser Ser Ser Thr Pro
305                 310                 315                 320 
Pro Trp Tyr Asn Tyr Gly Ser Ser Phe Ser Tyr Ile Glu Ser Val Ala
                325                 330                 335     
Ile Pro Ala Pro Ser Leu Val Lys Trp Leu Ser Gln Ile Glu Ile Tyr
            340                 345                 350         
Ser Lys Ser Ala Lys Ala Thr Pro Gln Ser Ala Asp Tyr Trp Ala Gly
        355                 360                 365             
His Thr Ile Thr Tyr His Tyr Gly Gly Asp Asn Gly Gln Ala Val Ala
    370                 375                 380                 
Asn Tyr Gly Asp Arg Thr Asn Pro Val Ala Val Asp Arg Tyr Asn Phe
385                 390                 395                 400 
Glu Gln Ala Asp Ile Tyr Arg Val Ser Ser Ser Val Ala Ser Ser Thr
                405                 410                 415     
Thr Ser Gly Val Lys Leu Leu Thr Thr Lys Ala Ile Phe Asp Gly Ile
            420                 425                 430         
Asn Thr Lys Asn Gly Leu Val Ser Tyr Arg Tyr Glu Lys Ser Ser Asn
        435                 440                 445             
Phe Phe Asn Glu Leu Lys Asp Thr Ile Thr Glu Leu Pro Val Gln Leu
    450                 455                 460                 
Ser Ser Pro Pro Thr Tyr Gly Asp Ala Glu Gln Tyr Ser His Arg Leu
465                 470                 475                 480 
Ser Tyr Val Ser Asn Ala Pro Thr Glu Tyr Ser Ser Gly Gly His Leu
                485                 490                 495     
Ile Leu Gly Leu Ile Pro Val Leu Gly Trp Thr His Thr Ser Leu Thr
            500                 505                 510         
Gln Thr Asn Gln Ile His Ser Asp Ser Ile Thr Gln Ile Pro Ala Val
        515                 520                 525             
Lys Val Ser Asn Leu Glu Ser Gly Thr Ser Val Val Ala Asn Pro Gly
    530                 535                 540                 
Phe Thr Gly Gly Asp Leu Leu Lys Arg Thr Ser Thr Gly Arg Met Gly
545                 550                 555                 560 
Thr Leu Lys Leu Thr Val Ala Gly Ile Leu Ser Arg Glu Met Thr Ile
                565                 570                 575     
Arg Ile Arg Tyr Ala Ala Thr Thr Asp Phe Lys Leu Gln Val Ile Tyr
            580                 585                 590         
Lys Gly Ile Leu Gln Ser Ser Tyr Asn Ser Asn Lys Thr Met Asn Lys
        595                 600                 605             
Gly Glu Asn Leu Thr Tyr Gly Lys Phe Lys Phe Ala Asn Phe Thr Leu
    610                 615                 620                 
Pro Ile Ser Leu Leu Ile Pro Ser Asp Leu Ser Ile Asp Val Gln Asn
625                 630                 635                 640 
Leu Ser Ser Gly Glu Glu Val Tyr Ile Asp Arg Ile Glu Phe Ile Pro
                645                 650                 655     
Val Gly Ala Thr Tyr Glu Ala Glu Gln Asp Leu Glu Asn Ala Lys Lys
            660                 665                 670         
Ala Val Asn Ala Leu Phe Thr Asn Thr Lys Asp Gly Leu Arg Pro Gly
        675                 680                 685             
Val Thr Asp Tyr Glu Val Asn Gln Ala Ala Asn Leu Val Glu Cys Leu
    690                 695                 700                 
Ser Asp Asp Leu Tyr Pro Asn Glu Lys Arg Leu Leu Phe Asp Ala Val
705                 710                 715                 720 
Arg Glu Ala Lys Arg Leu Ser Glu Ala Arg Asn Leu Leu Gln Asp Pro
                725                 730                 735     
Asp Phe Gln Glu Ile Asn Gly Glu Asn Gly Trp Thr Ala Ser Thr Gly
            740                 745                 750         
Ile Glu Val Ile Glu Gly Asp Ala Val Phe Lys Gly Arg Tyr Leu His
        755                 760                 765             
Leu Pro Gly Ala Arg Glu Ile Asp Thr Glu Thr Tyr Pro Thr Tyr Leu
    770                 775                 780                 
Tyr Gln Lys Val Glu Glu Gly Val Leu Lys Pro Tyr Thr Arg Tyr Arg
785                 790                 795                 800 
Leu Arg Gly Phe Val Gly Ser Ser Gln Gly Leu Glu Ile Tyr Thr Ile
                805                 810                 815     
Arg His Gln Thr Asn Arg Ile Val Lys Asn Val Pro Asp Asp Leu Leu
            820                 825                 830         
Pro Asp Val Pro Pro Val Asn Asn Asp Gly Arg Ile Asn Arg Cys Ser
        835                 840                 845             
Glu Gln Lys Tyr Val Asn Ser Arg Leu Glu Val Glu Asn Arg Ser Gly
    850                 855                 860                 
Glu Ala His Glu Phe Ser Ile Pro Ile Asp Thr Gly Glu Ile Asp Tyr
865                 870                 875                 880 
Asn Glu Asn Ala Gly Ile Trp Val Gly Phe Lys Ile Thr Asp Pro Glu
                885                 890                 895     
Gly Tyr Ala Thr Leu Gly Asn Leu Glu Leu Val Glu Glu Gly Pro Leu
            900                 905                 910         
Ser Gly Asp Ala Leu Glu Arg Leu Gln Arg Glu Glu Gln Gln Trp Lys
        915                 920                 925             
Ile Gln Met Thr Lys Arg Arg Glu Glu Thr Asp Arg Lys Tyr Met Ile
    930                 935                 940                 
Ala Lys Gln Ala Val Asp Arg Leu Tyr Ala Asp Tyr Gln Asp Gln Gln
945                 950                 955                 960 
Leu Asn Pro Asn Val Glu Ile Thr Asp Ile Thr Ala Ala Gln Asn Val
                965                 970                 975     
Ile Gln Ser Ile Pro Tyr Val Tyr Asn Asp Ala Phe Pro Gly Leu Pro
            980                 985                 990         
Gly Met Asn Tyr Thr Lys Phe Thr Glu Leu Thr Asp Arg Leu Gln Gln
        995                 1000                1005            
Ala Trp Ser Leu Tyr Asp Gln Arg Asn Ala Ile Pro Asn Gly Asp Phe
    1010                1015                1020                
Arg Asn Glu Leu Ser Asn Trp Asn Thr Thr Ala Gly Val Asn Val Gln
1025                1030                1035               1040 
Gln Leu Asn Gly Thr Ser Val Leu Val Ile Pro Asn Trp Asp Ala Gln
                1045                1050                1055    
Val Ser Gln Gln Phe Thr Val Gln Pro Asn Gln Arg Tyr Val Leu Arg
            1060                1065                1070        
Val Thr Ala Arg Lys Glu Gly Val Gly Asn Gly Tyr Val Ser Ile Arg
        1075                1080                1085            
Asp Gly Gly Asn Gln Thr Glu Thr Leu Thr Phe Ser Ala Ser Asp Tyr
    1090                1095                1100                
Asp Thr Asn Gly Val Tyr Asn Ile Gln Ala Ser Asn Thr Asn Gly Tyr
1105                1110                1115               1120 
Asn Thr Asn Gly Val Tyr Asn Asp Gln Thr Gly Tyr Ile Thr Lys Thr
                1125                1130                1135    
Ala Glu Phe Ile Pro His Thr Asn Gln Val Trp Ile Glu Met Ser Glu
            1140                1145                1150        
Thr Glu Gly Thr Phe Tyr Ile Glu Ser Val Glu Leu Ile Val Asp Val
        1155                1160                1165            
Glu
    


<210> 51
<211> 1212
<212> PRT
<213> Bacillus thuringiensis

<400> 51
Met Lys Asn Val Trp Lys Val Ile Leu Cys Asn Lys Cys Ile Gly Gly
 1               5                  10                  15      
Lys Arg Met Ser Pro Asn Asn Gln Asn Glu Phe Asp Ile Ile Asp Val
            20                  25                  30          
Pro Ser Asn Ile Ser Val Ser Asn Ser Phe Val Arg Tyr Pro Phe Ala
        35                  40                  45              
Asn Asp Pro Asn Arg Thr Leu Gln Asn Thr Asn Tyr Lys Asp Phe Leu
    50                  55                  60                  
Thr Met Ser Glu Lys Ser Asn Ser Gly Tyr Leu Thr Asp Pro Glu Ala
65                  70                  75                  80  
Phe Asp Asp Val Gly Ser Ala Ile Phe Ala Gly Leu Ser Ile Thr Ala
                85                  90                  95      
Lys Ile Met Asp Ala Phe Asp Val Pro Gly Gly Asp Ile Phe Asn Gly
            100                 105                 110         
Leu Leu Glu Ile Ile Gly Ile Leu Trp Asp Leu Gln Asp Asp Thr Trp
        115                 120                 125             
Glu Ala Phe Met Glu Gln Val Glu Val Leu Ile Asp Gln Lys Ile Ala
    130                 135                 140                 
Glu Tyr Ala Arg Asn Leu Ala Leu Thr His Leu Lys Gly Leu Glu Asn
145                 150                 155                 160 
Ser Tyr Lys Leu Tyr Leu Glu Ala Leu Ala Asp Trp Lys Gln Asn Pro
                165                 170                 175     
Thr Ser Pro Ser Ser Gln Glu Arg Val Arg Thr Arg Phe Arg Asp Thr
            180                 185                 190         
Asp Asp Ser Leu Thr Val Phe Met Pro Ser Phe Ala Val Lys Gly Tyr
        195                 200                 205             
Glu Val Pro Leu Leu Ala Val Tyr Ala Gln Ala Ala Asn Leu His Leu
    210                 215                 220                 
Leu Leu Leu Arg Asp Ser Val Ala Tyr Gly Leu Gly Trp Gly Leu Ser
225                 230                 235                 240 
Gln Leu Asn Val Asn Asp Asn Tyr Asn Arg His Val Arg Leu Thr Gly
                245                 250                 255     
Glu Tyr Thr Asn His Cys Val Ser Trp Tyr Thr Thr Gly Leu Glu Lys
            260                 265                 270         
Leu Arg Gly Ser Asn Ala Gln Ser Trp Ile Lys Phe Asn Arg Tyr Arg
        275                 280                 285             
Arg Glu Met Thr Val Met Val Leu Asp Ile Val Ala Leu Phe Pro Asn
    290                 295                 300                 
Tyr Asp Ala Arg Arg Tyr Pro Gln Ala Thr Thr Thr Glu Leu Thr Arg
305                 310                 315                 320 
Leu Ile Tyr Thr Asp Pro His Gly Tyr Thr Ile Tyr Ser Pro Thr Ser
                325                 330                 335     
Gln Thr Thr Ile Pro Trp Tyr Glu Tyr Gly Gln Ser Phe Ser Glu Ile
            340                 345                 350         
Glu Asn Val Ala Ile Gln Ala Pro Arg Leu Phe Arg Trp Ala Gln Glu
        355                 360                 365             
Met Gln Ile Tyr Thr Lys Phe Val Arg His Ala Pro Gln Glu Ser His
    370                 375                 380                 
Tyr Trp Ala Ala His Thr Phe Ser Phe His His Thr Arg Asp Asn Thr
385                 390                 395                 400 
Lys Thr Thr Leu Thr Tyr Gly Asp Thr Ser Asn Pro Ile Ser Val Gly
                405                 410                 415     
Thr Ala Asp Leu Ser Asp Leu Asp Ile Tyr Lys Val Ser Ser Leu Val
            420                 425                 430         
Ala Ser Ser Trp Gly Ser Gly Val Arg Leu Leu Val Thr Lys Ala Lys
        435                 440                 445             
Phe Glu Val Ile Tyr Thr Phe Asn Gln Leu Trp Glu Phe Asn Tyr Glu
    450                 455                 460                 
Pro Pro Gly Ile Ser Asn Phe Phe Asn Gln Trp Lys Asn Thr Asp Thr
465                 470                 475                 480 
Glu Leu Pro Ile Gln Ile Val Asp Pro Pro Thr Phe Gly Asp Pro Asn
                485                 490                 495     
Gln Tyr Ser His Arg Val Ala Tyr Ile Ser His Ala Pro Ile Gln Pro
            500                 505                 510         
Tyr Ser Gly Ala Phe Arg Asn Tyr Gly Leu Val Pro Val Phe Gly Trp
        515                 520                 525             
Ser His Val Ser Val Asp Arg Asn Asn Thr Leu Tyr Ala Asp Arg Ile
    530                 535                 540                 
Thr Gln Ile Pro Ala Val Lys Ala Val Gln Leu Ser Gly Glu Pro Tyr
545                 550                 555                 560 
Pro Val Val Arg Gly Pro Gly Phe Thr Gly Gly Asp Ile Ala Arg Leu
                565                 570                 575     
Pro Asn Asn Pro Asn Val Gly Leu Leu Phe Asn Ser Lys Val Glu Ser
            580                 585                 590         
Pro Ser Glu Asn Lys Arg Tyr Arg Val Arg Ile Arg Tyr Ala Cys Ala
        595                 600                 605             
Ser Gly Ala Arg Ala Ile Phe Gly Gly Leu Tyr Leu Pro Ile Thr Val
    610                 615                 620                 
Gln Phe Asn Gln Thr Met Ser Thr Thr Thr Pro Thr Arg Tyr Glu Asp
625                 630                 635                 640 
Phe Gln Tyr Val Asp Val Ser Gly Thr Phe Ile Leu Gly Asn Thr Asn
                645                 650                 655     
Val Ser Phe Ser Leu Val Pro Gln Ser Ala Asn Gln Thr Asn Asn Leu
            660                 665                 670         
Phe Ile Asp Lys Ile Glu Phe Ile Pro Glu Asn Pro Ala Leu Glu Ala
        675                 680                 685             
Glu Ser Asp Leu Glu Ala Ala Lys Lys Ala Val Asn Ala Leu Phe Thr
    690                 695                 700                 
Asn Ser Lys Asp Thr Leu Gln Ile Gly Val Thr Asp Tyr Gln Ile Asn
705                 710                 715                 720 
Gln Ala Ala Asn Leu Ile Glu Cys Val Ser Asp Glu Val Tyr Pro Asn
                725                 730                 735     
Glu Lys Arg Leu Leu Phe Asp Ala Val Lys Glu Ala Lys Arg Leu Ser
            740                 745                 750         
Thr Ala Arg Asn Leu Leu Glu Asp Thr Asp Phe His Thr Ile Asn Gly
        755                 760                 765             
Gly Asn Gly Trp Thr Gly Ser Thr Gly Ile Glu Ile Val Glu Gly Asp
    770                 775                 780                 
Ile Leu Phe Lys Asp Arg Ser Leu Arg Leu Pro Ser Ala Arg Glu Ile
785                 790                 795                 800 
Glu Arg Glu Thr Tyr Pro Thr Tyr Ile Tyr Gln Lys Ile Glu Glu Ser
                805                 810                 815     
Arg Leu Lys Pro Asn Thr Arg Tyr Ser Leu Arg Gly Phe Ile Gly Ser
            820                 825                 830         
Ser Gln Asp Leu Glu Ile Tyr Val Leu Arg His Gln Ala Tyr Arg Val
        835                 840                 845             
Ile Lys Asn Val Ser Asp Asn Leu Leu Pro Asn Met Arg Pro Ile Asn
    850                 855                 860                 
Ala Cys Gly Gly Val Asp Arg Cys Ser Gln Gln Lys Tyr Val Asn Asn
865                 870                 875                 880 
Ser Leu Glu Val Asn Ser Gly Leu Ser Asn Gly Ile Gly Ala Ala Asp
                885                 890                 895     
Ser His Glu Phe Ser Ile His Val Asp Thr Gly Glu Leu Asn Tyr Asn
            900                 905                 910         
Glu Asp Met Gly Ile Trp Val Val Phe Lys Ile Thr Thr Thr Asp Gly
        915                 920                 925             
Tyr Ala Thr Val Gly Asn Ile Glu Leu Val Glu Val Glu Thr Leu Ser
    930                 935                 940                 
Gly Glu Ala Leu Glu Arg Val Gln Arg Gln Glu Lys Gln Trp Gln Gly
945                 950                 955                 960 
Gln Leu Ala Thr Arg Arg Lys Glu Thr Glu Thr Arg Tyr Gly Pro Ala
                965                 970                 975     
Lys Gln Ala Ile Asp Arg Leu Phe Val Asp Phe Gln Asp Gln Gln Leu
            980                 985                 990         
Ser Arg Ser Thr Glu Ile Ser Asp Leu Thr Glu Ala Gln Asn Leu Val
        995                 1000                1005            
Gln Ser Ile Pro Tyr Val Tyr Asn Asp Met Leu Pro Glu Ile Pro Gly
    1010                1015                1020                
Met Asn Tyr Thr Ser Val Thr Glu Leu Thr Asn Arg Leu Gln Gln Ala
1025                1030                1035               1040 
Trp Asn Leu Tyr Asp Gln Arg Asn Ser Ile Gln Asn Gly Asp Phe Arg
                1045                1050                1055    
Asn Asp Val Ser Asn Trp Asn Val Thr Thr Glu Val Asn Ile Gln Gln
            1060                1065                1070        
Met Asn Asp Thr Ser Val Leu Val Ile Pro Asn Trp Asp Ser Gln Val
        1075                1080                1085            
Ser Gln Gln Ile Thr Val Gln Pro Asn Arg Arg Tyr Val Leu Arg Val
    1090                1095                1100                
Thr Ala Arg Lys Glu Gly Asn Gly Asp Gly Tyr Val Thr Ile Arg Asp
1105                1110                1115               1120 
Gly Ala Asn His Thr Glu Thr Leu Thr Phe Asn Thr Cys Asp Tyr Asp
                1125                1130                1135    
Gly Asn Ser Val Tyr Asn Asn Gln Pro Leu Asn Ala Asn Asn Asn Val
            1140                1145                1150        
Tyr Thr Thr Lys Ser Ser Asn Thr Asn Ser Tyr His Thr Asn Gly Val
        1155                1160                1165            
Tyr His Asp Gln Thr Ser Tyr Val Thr Lys Thr Met Glu Phe Thr Pro
    1170                1175                1180                
Tyr Thr Glu Gln Val Trp Val Glu Met Ser Glu Thr Glu Gly Val Phe
1185                1190                1195               1200 
Tyr Ile Asp Ser Val Glu Leu Ile Val Glu Glu Met
                1205                1210        


<210> 52
<211> 1231
<212> PRT
<213> Bacillus thuringiensis

<400> 52
Met Val Met Ser Ser Val Ser Ile Gly Gly Lys Lys Met Ser Gln Asn
 1               5                  10                  15      
Asn Gln Asn Glu Tyr Asp Ile Ile Asp Val Ser Ser Gly Asn Phe Ile
            20                  25                  30          
Ser Asn Asp Ser Val Arg Tyr Pro Leu Ala Asn Asn Pro Asn His Thr
        35                  40                  45              
Leu Gln Asn Ile Asn Tyr Lys Asp Tyr Leu Asn Met Ser Glu Gly Asn
    50                  55                  60                  
Ser Val Glu Leu Phe Gly Asp Ser Gln Ala Phe Asn Arg Val Ala Thr
65                  70                  75                  80  
Ala Gln Thr Gly Leu Ala Ile Val Gly Gly Ala Leu Gly Ala Leu Gly
                85                  90                  95      
Val Pro Phe Ala Gly Glu Ile Ala Gly Leu Phe Ser Phe Ile Leu Asp
            100                 105                 110         
Leu Phe Trp Pro Ser Gln Glu Thr Asp Val Trp Glu Met Ile Met Asp
        115                 120                 125             
Gln Val Gln Gly Leu Ile Asp Gln Ser Ile Thr Ala Asn Val Arg Ser
    130                 135                 140                 
Gln Ala Ile Ala Lys Leu Glu Gly Leu Gly Arg Gly Leu Glu Ala Tyr
145                 150                 155                 160 
Gln Glu Leu Leu Val Ala Trp Leu Glu Asn Arg Asn Asn Ala Arg Thr
                165                 170                 175     
Arg Ser Leu Ile Lys Gln Gln Tyr Val Ala Leu Glu Gln Ile Phe Thr
            180                 185                 190         
Thr Gly Leu Pro Glu Phe Ser Val Gln Asn Gln Glu Val Pro Leu Leu
        195                 200                 205             
Gly Val Tyr Ala Gln Ala Ala Asn Leu His Leu Leu Leu Leu Arg Asp
    210                 215                 220                 
Val Ser Ile Phe Gly Ala Glu Trp Gly Phe Glu Asp Tyr Glu Ile Asp
225                 230                 235                 240 
Val Phe Tyr Asn Arg Gln Met Arg Tyr Thr Ala Glu Tyr Ala Asn Tyr
                245                 250                 255     
Cys Val Glu Trp Tyr Asn Lys Gly Leu Asp Arg Leu Lys Gly Thr Asp
            260                 265                 270         
Arg Ile Ser Trp Met Lys Tyr His Gln Phe Arg Arg Glu Met Thr Leu
        275                 280                 285             
Leu Val Leu Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ala Arg Arg
    290                 295                 300                 
Tyr Pro Leu Glu Thr Glu Ala Gln Leu Thr Arg Glu Val Tyr Thr Asp
305                 310                 315                 320 
Pro Ile Val Tyr Asn Pro Glu Glu Phe Leu Gly Gly Phe Cys Asn Ser
                325                 330                 335     
Trp Thr Ser Asp Asn Gln Ser Asp Phe Ser Gln Ile Glu Asn Ala Val
            340                 345                 350         
Ile Arg Pro Pro His Val Phe Asp Thr Ile Ala Ser Leu Glu Ile Asn
        355                 360                 365             
Thr Ala Arg Gly Arg Ile Ala Leu Asn Asn Thr Ala Tyr Ile Asp Phe
    370                 375                 380                 
Trp Ala Gly His Ser Leu Thr Phe Arg Tyr Pro Asn Asp Ser Ala Arg
385                 390                 395                 400 
His Gln Val Gln Tyr Gly Thr Ile Thr Ser Glu Lys Asn Ser Phe Pro
                405                 410                 415     
Phe Glu Val Thr Asp Val Val Gln Val Asn Thr Thr Ala Ala Asn Leu
            420                 425                 430         
Ala Asn Ala Tyr Gln Gln Ala Tyr Gly Ala Pro Arg Ala Val Phe Gln
        435                 440                 445             
Leu Val Asn Arg Leu Asn Gly Ala Val Gly Ser Leu Thr Tyr Ser Lys
    450                 455                 460                 
Thr His Thr Ala Ile Gln Ala Cys Thr Gln Ser Leu Asn Thr Asn Ser
465                 470                 475                 480 
Glu Ile Pro Arg Leu Pro Val Ser Pro Gly Val Thr Asn Leu Ser Thr
                485                 490                 495     
Leu Tyr Thr His Arg Ile Ser His Ile Thr Ser Tyr Asn Phe Ser Asn
            500                 505                 510         
Asn Leu Ala Gly Asn Arg Asn Arg Tyr Gly Asn Phe Pro Val Phe Val
        515                 520                 525             
Trp Thr His Arg Ser Ala Glu Ile Asp Asn Lys Ile Tyr Ala Asn Lys
    530                 535                 540                 
Ile Thr Gln Ile Pro Ala Val Lys Ala Leu Trp Ala Ser Ser Glu Pro
545                 550                 555                 560 
Tyr Pro Val Val Arg Gly Pro Gly Phe Thr Gly Gly Asp Ile Ala Arg
                565                 570                 575     
Leu Pro Asn Asn Pro Asn Ile Gly Leu Arg Phe Leu Leu Asp Pro Glu
            580                 585                 590         
Pro Gly Val Leu Phe Asn Arg Arg Phe Arg Val Arg Ile Arg Phe Ala
        595                 600                 605             
Cys Asp Ser Gly Ala Arg Val Ile Leu Thr Asp Glu Thr Gly Ile Asn
    610                 615                 620                 
Ser Glu Thr Ile Val Leu Asn Gln Thr Met Thr Thr Glu Asn Pro Arg
625                 630                 635                 640 
Lys Tyr Asp Asp Phe Gln Tyr Ile Glu Ser Arg Asn Val Tyr Thr Leu
                645                 650                 655     
Thr Arg Phe Pro Gly Pro Trp Ile Trp Arg Leu Gly Ala Gln Ser Ala
            660                 665                 670         
Asp Gln Thr Arg Asn Val Tyr Ile Asp Arg Ile Glu Phe Ile Pro Leu
        675                 680                 685             
Asn Pro Ala Leu Glu Ala Glu Asn Asp Leu Glu Thr Ala Lys Lys Ala
    690                 695                 700                 
Val Asn Ala Leu Phe Thr Asn Arg Lys Asp Thr Leu Gln Ile Ser Val
705                 710                 715                 720 
Thr Asp Tyr Gln Ile Asn Gln Ala Ala Asn Leu Ile Glu Cys Val Ser
                725                 730                 735     
Asp Glu Val Tyr Pro Asn Glu Lys Arg Leu Leu Phe Asp Ala Val Lys
            740                 745                 750         
Glu Ala Lys Arg Leu Ser Thr Ala Arg Asn Leu Leu Glu Asp Thr Asp
        755                 760                 765             
Phe His Ala Ile Asn Gly Gly Asn Gly Trp Thr Gly Ser Thr Gly Ile
    770                 775                 780                 
Glu Ile Val Glu Gly Asp Leu Leu Phe Lys Asp Arg Ser Leu Arg Leu
785                 790                 795                 800 
Pro Ser Ala Arg Glu Ile Glu Arg Glu Thr Tyr Pro Thr Tyr Ile Tyr
                805                 810                 815     
Gln Lys Ile Glu Glu Ser Arg Leu Lys Pro Asn Thr Arg Tyr Ser Leu
            820                 825                 830         
Arg Gly Phe Ile Gly Ser Ser Gln Asp Leu Glu Ile Tyr Val Leu Arg
        835                 840                 845             
His Gln Ala Tyr Arg Val Ile Lys Asn Val Ser Asp Asn Leu Leu Pro
    850                 855                 860                 
Asn Met Arg Pro Ile Asn Ala Cys Gly Gly Val Asp Arg Cys Ser Gln
865                 870                 875                 880 
Gln Lys Tyr Val Asn Asn Ser Leu Glu Leu Asn Ser Ser Leu Ser Asn
                885                 890                 895     
Gly Ile Gly Ala Ala Asp Ser His Glu Phe Ser Ile His Met Asp Thr
            900                 905                 910         
Gly Glu Leu Asn Tyr Asn Glu Asp Thr Gly Ile Trp Val Val Phe Lys
        915                 920                 925             
Ile Thr Thr Thr Asp Gly Tyr Ala Thr Leu Gly Asn Leu Glu Leu Val
    930                 935                 940                 
Glu Glu Gly Pro Leu Ser Gly Asp Thr Leu Glu Arg Val Arg Lys Gln
945                 950                 955                 960 
Glu Lys Gln Trp Gln Asp Gln Met Ala Arg Arg Arg Ala Glu Thr Glu
                965                 970                 975     
Thr Arg Tyr Gly Ala Ala Lys Gln Ala Ile Asp Arg Leu Phe Ile Asp
            980                 985                 990         
Tyr Gln Asp Gln Gln Leu Ser Pro Gly Thr Asp Ile Ser Asp Leu Thr
        995                 1000                1005            
Ala Ala Gln Asn Val Val Gln Ser Ile Pro Tyr Val Tyr Asn Asp Met
    1010                1015                1020                
Leu Pro Glu Ile Pro Gly Met Asn Tyr Thr Ser Val Thr Glu Leu Thr
1025                1030                1035               1040 
Asn Arg Leu Gln Gln Ala Trp Asp Leu Tyr Asp Gln Arg Asn Ser Ile
                1045                1050                1055    
Pro Asn Gly Asp Phe Arg Tyr Gly Leu Asn Asp Trp Asn Ala Lys Ser
            1060                1065                1070        
Gly Ala Asn Val Gln Gln Val Asn His Thr Ser Val Leu Val Ile Pro
        1075                1080                1085            
Asn Trp Asp Ser Gln Ala Ser Gln Glu Ile Thr Val Gln Pro Asn Arg
    1090                1095                1100                
Arg Tyr Val Leu Arg Val Thr Ala Arg Lys Glu Gly Ser Gly Asp Gly
1105                1110                1115               1120 
Tyr Val Thr Ile Arg Asp Gly Ala Lys Tyr Thr Glu Thr Leu Thr Phe
                1125                1130                1135    
Asn Thr Cys Asp Tyr Asn Gly Ser Asn Val Tyr Gln Glu Gln Ala Leu
            1140                1145                1150        
Tyr Thr Asn Asp Val Tyr Asn Thr Gln Ser Ala Asn Ile Gln Gly Ser
        1155                1160                1165            
Asn Ser Ala Tyr His Thr Gln Ala Ser Asn Thr Asp Arg Tyr Asn Met
    1170                1175                1180                
Asn Gly Met Tyr Asn Asp Gln Thr Ser Tyr Val Thr Lys Thr Val Glu
1185                1190                1195               1200 
Phe Ile Pro His Thr Glu Gln Val Trp Ile Glu Met Ser Glu Thr Glu
                1205                1210                1215    
Gly Val Phe Tyr Ile Glu Ser Val Glu Leu Ile Val Lys Glu Asn
            1220                1225                1230    


<210> 53
<211> 1168
<212> PRT
<213> Bacillus thuringiensis

<400> 53
Met Thr Leu Asn Asn Asn Glu Tyr Glu Ile Ile Asp Thr Pro Ser Arg
 1               5                  10                  15      
Thr Ser Val Ser Asn Glu Ser Phe Arg Tyr Pro Leu Ala Ser Asn Gln
            20                  25                  30          
Ser Thr Ser Leu Gln Asn Arg Asn Tyr Lys Asp Trp Leu Asn Thr Leu
        35                  40                  45              
Glu Gly Gly Asn Asn Gln Gly Phe Ile Asn Ile Glu Gly Arg Leu Ser
    50                  55                  60                  
Leu Glu Gln Val Leu Ala Val Ser Ala Gly Val Ala Ser Tyr Ile Leu
65                  70                  75                  80  
Ser Asn Leu Gly Pro Phe Gly Val Phe Phe Ser Tyr Ile Ile Gly Ala
                85                  90                  95      
Phe Trp Pro Thr Ala Pro Ser Asp Thr Arg Val Trp Glu Ala Phe Met
            100                 105                 110         
Glu Leu Ile Glu Ala Arg Ile Asp Gln Lys Ile Gln Glu Ser Thr Arg
        115                 120                 125             
Lys Asp Ala Ile Ala Arg Leu Gln Gly Leu Gly Ala Ala Ser Glu Val
    130                 135                 140                 
Tyr Gln Glu Ser Leu Glu Ser Trp Leu Glu Asn Gln Asn Asp Ala Arg
145                 150                 155                 160 
Ala Met Ser Val Val Arg Gln Gln Phe Val Ala Phe Glu Leu Asp Phe
                165                 170                 175     
Val Thr Ala Met Pro Phe Phe Glu Arg Ser Gly Asp Glu Ile Leu Leu
            180                 185                 190         
Leu Ala Val Tyr Ala Gln Ala Ala Asn Leu His Leu Leu Leu Leu Arg
        195                 200                 205             
Asp Ala Ser Leu Tyr Gly Ala Asp Trp Gly Met Glu Pro Tyr Asp Ile
    210                 215                 220                 
Ala Asn Tyr Tyr Asn Arg Gln Lys Glu Arg Thr Ala Thr Tyr Ser Asn
225                 230                 235                 240 
His Cys Met Glu Trp Tyr Lys Lys Gly Leu Asp Glu Leu Trp Ser Ala
                245                 250                 255     
Gly Gly Tyr Gly Gly Asp Val Trp Gln Asp Tyr Asn Asp Phe Arg Arg
            260                 265                 270         
Glu Met Thr Leu Ser Val Leu Asp Phe Val Ala Leu Phe Pro Asn Tyr
        275                 280                 285             
Asp Thr His Leu Tyr Pro Ile Glu Val Lys Gly Glu Leu Thr Arg Glu
    290                 295                 300                 
Ile Tyr Thr Pro Gly Ile Asn Ile Asp Ile Asp Arg Gly Arg Leu Gly
305                 310                 315                 320 
Lys Val Thr Leu Glu Asn Ala Leu Val Asn Ser Pro Arg Leu Phe Ser
                325                 330                 335     
Trp Leu Lys Glu Ile Gln Leu Phe Thr Asn Ile Asn Phe Asn Pro Arg
            340                 345                 350         
Trp Lys Phe Leu Ser Ala Thr Arg Ile Gly Tyr Lys Leu Thr Gly Tyr
        355                 360                 365             
Arg Ser Val Asn Phe Glu Pro Tyr Glu Gly Phe Tyr Phe Glu Gly Leu
    370                 375                 380                 
Phe Gln Ser Asn Phe Thr Leu Asn Asp Tyr Gln Glu Ile Tyr Ile Val
385                 390                 395                 400 
Asp Val Thr Arg Phe Gly Ser Leu Tyr Asp Thr Pro Thr Ala Ile Thr
                405                 410                 415     
Ala Met Thr Phe Phe Lys Asp Asp Asn Thr Thr Phe Asn Tyr Ser Ser
            420                 425                 430         
Asn Thr Pro Ser Gly Glu Pro Met Ile Thr Ser Gly Phe Tyr Leu Pro
        435                 440                 445             
Gly Ile Asp Gly Ser Glu Glu Pro Thr Ser Asn Asn Phe Ser His Arg
    450                 455                 460                 
Leu Ser Thr Ile Asn Thr Tyr Asn Thr Thr Asn Gln Thr Phe Tyr His
465                 470                 475                 480 
Thr Phe Gly Trp Thr His Val Ser Val Asp Arg Asn Asn Thr Ile Val
                485                 490                 495     
Ser Asn Lys Ile Thr Gln Ile Pro Phe Val Lys Ala Asn Thr Gly Asn
            500                 505                 510         
Val Val Arg Gly Pro Gly His Thr Gly Gly Asp Leu Val Val Phe Lys
        515                 520                 525             
Pro Ala Ala Arg Pro Asp Ile Val Leu Arg Val Gly Asn Thr Arg Leu
    530                 535                 540                 
Gln Ser Tyr Arg Val Arg Val Arg Tyr Ala Ser Asn Ala Asp Ile Ser
545                 550                 555                 560 
Leu Glu Leu Asp Thr Thr Tyr Glu Lys Thr Asn Ile His Leu Gln Lys
                565                 570                 575     
Thr Phe Asn Ser Ser Glu Ala Glu Asp Leu Thr Tyr Asp Asn Phe Gln
            580                 585                 590         
Tyr Ala Glu Ala Asp Asn Ile Val Trp Leu Gly Gln Asp Leu Ser Gln
        595                 600                 605             
Tyr Ile Glu Phe Gln Asn Ala Ile Thr Asn Asp Ser Thr Ala Ile Ala
    610                 615                 620                 
Tyr Phe Glu Arg Val Glu Phe Leu Pro Val Gly Ala Thr Tyr Glu Ala
625                 630                 635                 640 
Glu Gln Asp Leu Glu Thr Ala Lys Lys Val Val Asn Ala Leu Phe Thr
                645                 650                 655     
Asn Thr Lys Asn Ala Leu Gln Met Ser Val Thr Asp Tyr Glu Val Thr
            660                 665                 670         
Gln Ala Ala Asn Leu Val Glu Cys Val Ser Asp Glu Leu Phe Pro Asn
        675                 680                 685             
Glu Lys Arg Leu Leu Phe Asp Ala Val Lys Glu Ala Lys Arg Leu Ser
    690                 695                 700                 
Gly Ile Arg Asn Leu Leu Gln Asp Ser Asp Phe Gln Glu Ile Asn Gly
705                 710                 715                 720 
Glu Asn Gly Trp Val Gly Ser Ile Glu Ile Glu Ile Arg Glu Gly Asp
                725                 730                 735     
Thr Leu Phe Lys Gly Tyr Ser Leu Arg Leu Pro Ser Ala Arg Glu Ile
            740                 745                 750         
Tyr Met Glu Met Phe Pro Thr Tyr Leu His Gln Lys Ile Glu Glu Ser
        755                 760                 765             
Arg Leu Lys Pro Tyr Thr Arg Tyr Arg Leu Arg Gly Phe Val Ser Ser
    770                 775                 780                 
Ser Gln Asp Leu Glu Ile Phe Ser Ile Arg His Glu Thr Asn Arg Ile
785                 790                 795                 800 
Val Lys Asn Val Ser Asp Asp Leu Leu Pro Asn Leu Ser Ser Tyr Tyr
                805                 810                 815     
Thr Cys Gly Gly Val Asn Arg Cys Ser Thr Gln Lys Tyr Val Tyr Asn
            820                 825                 830         
Arg Leu Glu Phe Gln Asn Ser Leu Ser Ser Gly Asn Arg Tyr Ser Asp
        835                 840                 845             
Ala His Ser Phe Ser Ile Pro Ile Asp Thr Gly Lys Ile Asp Leu Asn
    850                 855                 860                 
Asp Asn Thr Gly Ile Trp Ile Ala Phe Lys Leu Ala Thr Thr Gly Gly
865                 870                 875                 880 
Tyr Ala Thr Leu Gly Asn Leu Glu Leu Val Glu Glu Ala Pro Leu Ile
                885                 890                 895     
Gly Asp Thr Leu Glu Arg Val Gln Arg Glu Asp Gln Gln Trp Lys Ser
            900                 905                 910         
Gln Met Thr Arg Lys Arg Glu Glu Ala Glu Arg Lys Tyr Met Ala Ala
        915                 920                 925             
Lys Gln Ala Ile Asp Arg Leu Tyr Ala Asp Tyr Gln Asp His Gln Leu
    930                 935                 940                 
Asn Pro Asn Val Glu Ile Thr Asp Ile Thr Ala Thr Gln His Leu Val
945                 950                 955                 960 
Gln Ser Leu Pro Tyr Val Asn Asn Asp Val Leu Gln Glu Ile Pro Gly
                965                 970                 975     
Met Asn Tyr Thr Arg Phe Thr Glu Leu Thr Asn Arg Leu Gln Gln Ala
            980                 985                 990         
Trp Glu Leu Tyr Gly Leu Arg Asn Met Ile Ala Asn Gly Asp Phe Arg
        995                 1000                1005            
Asn Gly Leu Asn Asp Trp Asp Ala Thr Ser Gly Val Asn Ile Gln Gln
    1010                1015                1020                
Ile Asn His Thr Ser Val Leu Val Ile Ser Asn Trp Asp Ala Gln Ile
1025                1030                1035               1040 
Ser Lys Gln Phe Thr Val Gln Pro Asn Gln Lys Tyr Val Leu Arg Val
                1045                1050                1055    
Thr Val Arg Lys Glu Gly Ser Gly Asp Gly Tyr Val Thr Ile Arg Asp
            1060                1065                1070        
Gly Gly Asn His Thr Glu Thr Leu Thr Phe Asn Thr Cys Asp Tyr Glu
        1075                1080                1085            
Arg Ser Asn Val Tyr Asn Glu Lys Val Phe Gln Ser Asn Asp Tyr Gly
    1090                1095                1100                
Thr Asn Asn Val Tyr His Thr Gln Thr Thr Asn Ala Asn Arg Tyr Thr
1105                1110                1115               1120 
Thr Asn Ser Leu Tyr Asn Asp Gly Thr Gly Tyr Val Thr Lys Thr Val
                1125                1130                1135    
Glu Phe Ile Pro Tyr Thr Glu Gln Val Trp Ile Glu Met Ser Glu Thr
            1140                1145                1150        
Glu Gly Val Phe Tyr Val Glu Ser Ile Glu Phe Ile Leu Glu Glu Val
        1155                1160                1165            


<210> 54
<211> 1204
<212> PRT
<213> Bacillus thuringiensis

<400> 54
Met Asn Ile Gln Asn Ser Asn Asp Ala Asn Thr Asn Arg Ile Leu Asn
 1               5                  10                  15      
Asn Gly Leu Ser Val Ser Ser Thr Ala Asn Leu Leu Glu Leu Val Gln
            20                  25                  30          
Gln Gly Arg Ser Asp Tyr Ala Gly Lys Cys Tyr Ser Gly Tyr Ile Asp
        35                  40                  45              
Leu Ile Gly Glu Pro Arg Ser Thr Pro Ile Ser Asn Arg Phe Ser Asn
    50                  55                  60                  
Ser Ile Leu Pro Asn Thr Ile Thr Asn Asp Pro Arg Ile Val Glu Thr
65                  70                  75                  80  
Cys Gly Asn Gly Ser Ile Val Asp Asn Thr Val Gln Asp Ser Ile Thr
                85                  90                  95      
Thr Val Ile Asp Ile Thr Asn Ile Ile Leu Asp Leu Phe Asn Val Pro
            100                 105                 110         
Ile Val Gly Pro Val Leu Ser Ile Val Asn Arg Leu Ile Asn Arg Leu
        115                 120                 125             
Trp Pro Ser Asn Tyr Gly Thr Ala Ile Trp Glu Ala Leu Met Ala Glu
    130                 135                 140                 
Val Glu Lys Ile Val Asp Lys Lys Ile Asp Glu Ala Val Lys Ser Lys
145                 150                 155                 160 
Ala Leu Ser Glu Leu Glu Gly Leu Gln Arg Ile Tyr Ser Ser Tyr Gln
                165                 170                 175     
Ser Asp Leu Glu Arg Trp Leu Gly Asp Arg Asp Asn Pro Glu Tyr Gln
            180                 185                 190         
Glu Ile Ile Arg Gln Gln Phe Asn Val Val Asn Asn Phe Phe Ala Tyr
        195                 200                 205             
Gln Met Pro Ser Phe Ala Val Ser Gly Phe Glu Ile Leu Leu Leu Ser
    210                 215                 220                 
Val Tyr Thr Gln Ala Ala Asn Leu His Leu Asn Leu Leu Arg Asp Ile
225                 230                 235                 240 
Thr Val His Gly Thr Gly Trp Gly Tyr Ser Glu Gly Thr Val Glu Arg
                245                 250                 255     
Tyr Asn Gln Leu Gln Arg Cys Leu Ile Thr Ala Tyr Val Asp Tyr Cys
            260                 265                 270         
Val Asp Gln Tyr Asn Leu Glu Leu Glu Lys Leu Pro Lys Glu Thr Leu
        275                 280                 285             
Lys Asn Trp Val Asp Tyr Asn Arg Tyr Arg Arg Glu Met Thr Leu Ser
    290                 295                 300                 
Val Leu Asp Ile Val Ser Leu Phe Pro Asn Tyr Asp Ala Ser Val Tyr
305                 310                 315                 320 
Asp Leu Pro Ile Asn Ala Glu Leu Ser Arg Gln Val Tyr Thr Asp Pro
                325                 330                 335     
Leu Gly Ser Tyr Leu Pro Tyr Asn Thr Ala Asn Pro Ile Ser Trp Tyr
            340                 345                 350         
Asp Met Lys Ser Tyr Ile His Pro Asn Phe Trp Gln Ile Asp Lys Tyr
        355                 360                 365             
Phe Ile Lys Pro Pro Asn Leu Phe Thr Phe Ala Glu Lys Leu Ile Met
    370                 375                 380                 
Tyr Ser Gly Tyr Arg Thr Asp Val Asp Pro Ile Phe Tyr Tyr Tyr Trp
385                 390                 395                 400 
Ser Gly Ser Lys Leu Glu Ser Arg Arg Val His Gly Asn Glu Ile Ile
                405                 410                 415     
Thr Thr Ile Ser Gly Asp Ile Ser Gln Ser Ile Thr Leu Val Asn Val
            420                 425                 430         
Asp Phe Lys Asp Ser Asp Ile Tyr Lys Ile Thr Thr Asn Tyr Ile Gly
        435                 440                 445             
Gln Tyr Thr Gly Ser Leu Leu Gly Thr Asn Pro Ile Thr Phe Ser Leu
    450                 455                 460                 
Thr Asn Ser Asn Gly Gln Thr Glu Arg Lys Tyr Glu Tyr Ser Lys Leu
465                 470                 475                 480 
Leu Met Pro Gly Lys Glu Lys Ile Tyr Tyr Ser Gln Asp Glu Ile Pro
                485                 490                 495     
Pro Asn Ile Glu Thr Gly Glu Pro Asp Tyr Val Ala Tyr Ser His Arg
            500                 505                 510         
Leu Ser Tyr Val Ser Ala Phe Asn Pro Asn Phe Thr Ser Gly Lys Lys
        515                 520                 525             
Ile Gly Thr Val Pro Ile Tyr Gly Trp Thr His Thr Ser Val Ser Arg
    530                 535                 540                 
Asp Asn Leu Ile Tyr Pro Asp Lys Ile Thr Gln Ile Pro Ile Val Lys
545                 550                 555                 560 
Ser Tyr Glu Ile Gly Glu Tyr Tyr Lys Val Met Gln Gly Pro Gly Phe
                565                 570                 575     
Thr Gly Gly Asp Ile Leu Thr Lys Thr Tyr Pro Val Gln Asn Pro Ser
            580                 585                 590         
Gly Ser Thr Leu Ala Ala Arg Ile Arg Val Ser Thr Ala Gly Ile His
        595                 600                 605             
Leu Asn Gln Arg Tyr Thr Leu Arg Met His Tyr Ala Ala Ser Gly Ser
    610                 615                 620                 
Val Tyr Asp Ala Met Ile Ile Lys Pro Gly Gln Ser Glu Gly Gly Tyr
625                 630                 635                 640 
His Met Arg Leu Asn Pro Thr Met Glu Asn Gly Glu Thr Leu Thr Phe
                645                 650                 655     
Asn Ser Phe Thr Ser Ile Gly Met Asn Ser Gln Val Leu Thr Ser Ser
            660                 665                 670         
Gln Thr Asp Leu Thr Leu Tyr Ile Lys Ser Met Ser Pro Ser Thr Pro
        675                 680                 685             
Gly Thr Ile Tyr Ile Asp Arg Ile Glu Phe Ile Pro Val Asp Asn Asn
    690                 695                 700                 
Tyr Glu Ala Glu Gln Asn Leu Glu Lys Ala Gln Lys Ala Val Asn Ala
705                 710                 715                 720 
Leu Phe Thr Ala Gly Arg Asn Ala Leu Gln Thr Asp Val Thr Asp Tyr
                725                 730                 735     
Lys Val Asp Gln Val Ser Ile Val Val Asp Cys Val Ser Lys Glu Val
            740                 745                 750         
Tyr Pro Asn Glu Lys Arg Glu Leu Gln Asn Leu Val Lys Tyr Ala Lys
        755                 760                 765             
Arg Leu Thr Asn Ser Arg Asn Leu Leu Val Asp Pro Asn Phe Thr Ser
    770                 775                 780                 
Ile Asn Ser Glu Gly Val Asn Gly Trp Tyr Gly Ser Asn Gly Ile Val
785                 790                 795                 800 
Ile Gly His Gly Asp Asp Val Phe Lys Gly Asn Tyr Ile Gln Leu Ala
                805                 810                 815     
Gly Thr Asn Asp Ala Gln Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp
            820                 825                 830         
Glu Ser Lys Leu Lys Glu Tyr Thr Arg Tyr Lys Leu Arg Gly Phe Ile
        835                 840                 845             
Lys Ser Ser Gln Asp Leu Glu Ala Tyr Val Ile Arg Tyr Asp Ala Lys
    850                 855                 860                 
His Glu Thr Leu Asp Val Ser Asn Asn Leu Phe Pro Asp Ile Ser Pro
865                 870                 875                 880 
Val Asn Ala Cys Gly Glu Pro Asn Arg Cys Gly Ala Leu Gln Tyr Leu
                885                 890                 895     
Asp Glu Asn Pro Arg Leu Glu Cys Ser Ser Ile Gln Asp Gly Ile Leu
            900                 905                 910         
Ser Asp Ser His Ser Phe Ser Leu Asn Ile Asp Thr Gly Ser Ile Asp
        915                 920                 925             
Phe Asn Glu Asn Val Gly Ile Trp Val Leu Phe Lys Ile Ser Thr Pro
    930                 935                 940                 
Glu Gly Tyr Ala Arg Phe Gly Asn Leu Glu Val Ile Glu Asp Asp Thr
945                 950                 955                 960 
Val Ile Gly Glu Ala Leu Ala Arg Val Lys Arg Gln Glu Thr Lys Trp
                965                 970                 975     
Arg Asn Lys Leu Thr Gln Leu Arg Thr Glu Thr Gln Ala Ile Tyr Thr
            980                 985                 990         
Arg Ala Lys Gln Ala Ile Asp Asn Leu Phe Thr Asn Ala Gln Asp Ser
        995                 1000                1005            
His Leu Lys Ile Gly Ala Thr Phe Ala Ser Ile Val Ala Ala Arg Lys
    1010                1015                1020                
Ile Val Gln Ser Ile Arg Glu Ala Tyr Met Pro Trp Leu Ser Ile Val
1025                1030                1035               1040 
Pro Gly Val Asn Tyr Pro Ile Phe Thr Glu Leu Asn Glu Arg Val Gln
                1045                1050                1055    
Arg Ala Phe Gln Leu Tyr Asp Val Arg Asn Val Val Arg Asn Gly Arg
            1060                1065                1070        
Phe Leu Ser Gly Val Ser Asp Trp Ile Val Thr Ser Asp Val Lys Val
        1075                1080                1085            
Gln Glu Glu Asn Gly Asn Asn Val Leu Val Leu Ser Asn Trp Asp Ala
    1090                1095                1100                
Gln Val Leu Gln Cys Leu Lys Leu Tyr Gln Asp His Gly Tyr Ile Leu
1105                1110                1115               1120 
Arg Val Thr Ala Arg Lys Glu Gly Leu Gly Glu Gly Tyr Ile Thr Ile
                1125                1130                1135    
Thr Asp Glu Glu Gly His Thr Asp Gln Leu Thr Phe Gly Thr Cys Glu
            1140                1145                1150        
Glu Ile Asp Ala Ser Asn Met Phe Val Thr Thr Gly Tyr Met Thr Lys
        1155                1160                1165            
Glu Leu Glu Phe Phe Pro Asn Thr Glu Lys Val Arg Ile Glu Ile Gly
    1170                1175                1180                
Glu Thr Glu Gly Thr Phe Gln Val Glu Ser Ile Glu Leu Phe Leu Met
1185                1190                1195               1200 
Glu Asp Leu Cys
                


<210> 55
<211> 1131
<212> PRT
<213> Bacillus thuringiensis

<400> 55
Met Asn Gln Lys Asn Tyr Asp Ile Met Gly Ala Ser Thr Asn Ala Thr
 1               5                  10                  15      
Ala Glu Leu Thr Glu Asn Tyr Asn Thr Ile Ile Ser Pro Tyr Gly Ala
            20                  25                  30          
Pro Thr Ser Val Thr Thr Thr Ile Glu Ile Thr Gly Thr Ile Leu Ser
        35                  40                  45              
Asp Leu Gly Val Pro Gly Ala Ser Ser Ile Ser Leu Leu Leu Asn Lys
    50                  55                  60                  
Leu Leu Ser Ile Leu Trp Pro Asp Asp Thr Asn Thr Met Trp Gly Thr
65                  70                  75                  80  
Phe Ala Lys Glu Thr Ala Tyr Leu Leu Asn Glu Val Leu Ser Pro Asn
                85                  90                  95      
Asp Pro Val Val Ile Asp Ala Asp Asn Lys Leu Glu Gly Leu Lys Asn
            100                 105                 110         
Thr Leu Asp Leu Tyr Leu Glu Ala Leu Lys Glu Trp Lys Asn Asp Pro
        115                 120                 125             
Gln Asn Pro Ala Ser Gln Glu Arg Val Arg Thr Arg Phe Arg Asn Val
    130                 135                 140                 
Asp Asp Asp Phe Thr His Asp Met Pro Ser Phe Ala Arg Ala Gly Tyr
145                 150                 155                 160 
Glu Thr Lys Leu Leu Thr Val Tyr Ala Gln Ala Ala Asn Leu His Leu
                165                 170                 175     
Leu Leu Leu Arg Asp Ala Ser Met Phe Gly Glu Gly Trp Gly Met Thr
            180                 185                 190         
Gln Val Asn Ile Asn Asp Asn Tyr Asn Arg Gln Leu Arg Leu Thr Ala
        195                 200                 205             
Gln Tyr Thr Asp His Ser Val Lys Trp Tyr Asn Ala Gly Leu Glu Lys
    210                 215                 220                 
Leu Lys Gly Lys Leu Thr Gly Glu Asn Trp Tyr Thr Tyr Asn Arg Phe
225                 230                 235                 240 
Arg Arg Glu Met Thr Leu Met Val Leu Asp Val Val Ala Leu Phe Pro
                245                 250                 255     
Asn Tyr Asp Thr Arg Met Tyr Pro Ile Ala Thr Thr Ser Glu Leu Thr
            260                 265                 270         
Arg Ile Ile Tyr Thr Asp Pro Ile Ala Tyr Thr Gln Asp His Pro Trp
        275                 280                 285             
Tyr Lys Ile Thr Ser Leu Ser Phe Ser Asp Ile Glu Asn Ser Ala Ile
    290                 295                 300                 
Pro Ser Pro Ser Phe Phe Arg Trp Leu Lys Ser Val Ser Ile Asn Ser
305                 310                 315                 320 
Gln Trp Trp Gly Ser Gly Pro Asn Gln Thr Tyr Tyr Trp Val Gly His
                325                 330                 335     
Glu Leu Val Tyr Thr Asn Ser Asn Tyr Asn Gln Ser Leu Lys Val Lys
            340                 345                 350         
Tyr Gly Asp Pro Asn Ser Tyr Ile Glu Pro Pro Asp Ser Phe Asn Phe
        355                 360                 365             
Ser Ser Thr Asp Val Tyr Arg Thr Ile Ser Ile Ala Lys Asn Ser Ile
    370                 375                 380                 
Ser Asn Tyr Ile Val Ser Glu Val Arg Phe Asn Ser Ile Ser Asn Thr
385                 390                 395                 400 
Asn Lys Ile Ser Glu Glu Ile Tyr Lys His Gln Ser Asn Trp Pro Leu
                405                 410                 415     
Lys Glu Thr Lys Asp Ser Ile Ala Glu Leu Ser Ile Ala Ala Asn Pro
            420                 425                 430         
Pro Thr Thr Phe Gly Asn Val Ala Glu Tyr Ser His Arg Leu Ala Tyr
        435                 440                 445             
Ile Ser Glu Ala Tyr Ser Ser His Asn Pro Ser Lys Tyr Pro Ala Tyr
    450                 455                 460                 
Ile Pro Val Tyr Gly Trp Thr His Thr Ser Val Arg Tyr Asp Asn Lys
465                 470                 475                 480 
Ile Tyr Pro Asp Lys Ile Thr Gln Ile Pro Ala Val Lys Ser Ala Ser
                485                 490                 495     
Val Glu Gly Gly Thr Trp Lys Asn Val Val Lys Gly Pro Gly Phe Thr
            500                 505                 510         
Gly Gly Asp Val Thr Thr Ala Val Ser Pro Ala Asn Leu Ile Asp Val
        515                 520                 525             
Ile Lys Ile His Val Thr Leu Asp Ser Asn Ser Leu Ser Gln Lys Tyr
    530                 535                 540                 
Arg Ala Arg Leu Arg Tyr Ala Ser Asn Ala Tyr Val Ala Ala Thr Leu
545                 550                 555                 560 
Tyr Thr Asn Thr Ser Ser Asn Tyr His Phe Glu Leu Thr Lys Gly Thr
                565                 570                 575     
Thr Glu Gln Phe Ser Thr Tyr Asn Ser Phe Gln Tyr Val Asp Ile Pro
            580                 585                 590         
Gly Ser Ile Gln Phe Asn Asn Thr Ser Asp Thr Val Ser Val Tyr Leu
        595                 600                 605             
His Met Asp Ser Thr Thr Asn Ala Ser Val Gln Val Asp Arg Ile Glu
    610                 615                 620                 
Phe Ile Pro Val Asp Ile Asn Tyr Asp Glu Arg Val Gln Leu Glu Lys
625                 630                 635                 640 
Thr Gln Lys Ala Val Thr Ala Leu Phe Thr Ala Gly Lys His Ala Leu
                645                 650                 655     
Gln Thr Asp Val Thr Asp Tyr Lys Val Asp Gln Val Ser Ile Leu Val
            660                 665                 670         
Asp Cys Val Ser Ser Glu Leu Tyr Pro Asn Glu Lys Arg Glu Leu Gln
        675                 680                 685             
Asn Leu Val Lys Tyr Ala Lys Arg Leu Ser Tyr Ser Arg Asn Leu Leu
    690                 695                 700                 
Leu Asp Pro Thr Phe Asp Ser Ile Asn Ser Ser Val Glu Asn Gly Trp
705                 710                 715                 720 
Tyr Gly Ser Asn Gly Ile Ala Ile Gly Asn Gly Asp Tyr Val Phe Lys
                725                 730                 735     
Gly Asn Tyr Leu Ile Phe Ser Gly Thr Asn Asp Thr Gln Tyr Pro Thr
            740                 745                 750         
Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Glu Tyr Thr Arg
        755                 760                 765             
Tyr Lys Leu Arg Gly Phe Ile Glu Asn Ser Gln Asp Leu Glu Ala Tyr
    770                 775                 780                 
Val Val Arg Tyr Asp Ala Lys His Glu Thr Leu Asp Val Ser Asn Asn
785                 790                 795                 800 
Leu Leu Pro Asp Val Leu Pro Val Asn Ala Cys Gly Glu Pro Asn Arg
                805                 810                 815     
Cys Val Ala Leu Gln Tyr Leu Asp Lys Asn Pro Arg Leu Glu Cys Ser
            820                 825                 830         
Ser Ile Gln Asp Gly Ile Leu Ser Asp Ser His Ser Phe Ser Leu Asn
        835                 840                 845             
Ile Asp Thr Gly Ser Ile Asp Leu Asn Glu Asn Val Gly Ile Trp Val
    850                 855                 860                 
Leu Phe Lys Ile Ser Thr Pro Glu Gly Tyr Ala Lys Phe Gly Asn Leu
865                 870                 875                 880 
Glu Val Ile Glu Asp Gly Pro Val Ser Gly Glu Ala Leu Ala Arg Val
                885                 890                 895     
Lys Arg Gln Glu Thr Lys Trp Arg Asn Lys Leu Ala Gln Leu Arg Thr
            900                 905                 910         
Glu Thr Gln Ala Ile Tyr Thr Arg Ala Lys Gln Ala Leu Asp Asn Leu
        915                 920                 925             
Phe Thr Asp Ala Gln Asp Ser Tyr Leu Lys Ile Gly Ala Thr Phe Ala
    930                 935                 940                 
Ala Ile Val Ala Ala Arg Lys Ile Val Gln Ser Ile Arg Glu Ala Tyr
945                 950                 955                 960 
Met Ser Trp Leu Ser Val Val Pro Gly Val Asn Tyr Pro Ile Phe Thr
                965                 970                 975     
Glu Leu Asn Glu Arg Val Gln Arg Ala Phe Gln Leu Tyr Asp Gly Arg
            980                 985                 990         
Asn Val Val Arg Asn Gly Gln Phe Leu Asn Gly Val Leu Asp Trp Ile
        995                 1000                1005            
Val Thr Ser Asp Val Ser Val Gln Glu Glu Asn Gly Asn Asn Val Leu
    1010                1015                1020                
Val Leu Ser Asn Trp Asp Ala Gln Val Leu Gln Cys Leu Lys Leu Tyr
1025                1030                1035               1040 
Gln Asp Arg Gly Tyr Ile Leu Arg Val Thr Ala Arg Lys Glu Gly Leu
                1045                1050                1055    
Gly Glu Gly Tyr Ile Thr Ile Thr Asp Glu Glu Gly Asn Thr Asp Gln
            1060                1065                1070        
Leu Thr Phe Gly Ser Cys Glu Glu Ile Asp Thr Ser Asn Ser Phe Val
        1075                1080                1085            
Ser Thr Gly Tyr Met Thr Lys Glu Leu Glu Phe Phe Pro Asp Thr Glu
    1090                1095                1100                
Lys Val His Ile Glu Ile Gly Glu Thr Glu Gly Ile Phe Gln Val Glu
1105                1110                1115               1120 
Ser Val Glu Leu Phe Leu Met Glu Asp Leu Cys
                1125                1130    


<210> 56
<211> 775
<212> PRT
<213> Bacillus thuringiensis

<400> 56
Met Arg Ile Asn Pro Ile Ile Lys Cys Val Ala Thr Thr Thr Leu Phe
 1               5                  10                  15      
Ser Gln Phe Leu Thr Tyr Ser Ser Val Ser Tyr Ala Glu Glu Lys Gln
            20                  25                  30          
Ser Gln Thr Lys Ile Lys Gln Val Met Gln Ser Glu Lys Ala Ser Gln
        35                  40                  45              
Val Ser Asn Glu Ser Ser Gln Gly Leu Leu Gly Tyr Tyr Phe Gln Asp
    50                  55                  60                  
Ser Asn Phe Gln Gln Leu Thr Met Met Ala His Arg Gln Val Ser Asp
65                  70                  75                  80  
Leu Gln Ile Thr Lys Lys Glu Val Lys Asn Leu Leu Ala Asp Asp Gln
                85                  90                  95      
Gln His Ile Gly Ser Val Arg Trp Ile Gly Tyr Ile Gln Pro Ser Gln
            100                 105                 110         
Thr Gly Asp Tyr Ile Leu Ser Thr Ser Ser Asp Gln Gln Val Val Ile
        115                 120                 125             
Glu Leu Asp Gly Lys Ile Ile Leu Asn Gln Ser Ser Met Thr Glu Ala
    130                 135                 140                 
Ile Gln Leu Glu Lys Gly Lys Pro Tyr Lys Ile Arg Ile Glu Tyr Val
145                 150                 155                 160 
Pro Glu Asn Lys Lys Asn Lys Asp Asn Leu Leu Asp Phe Glu Leu Asn
                165                 170                 175     
Trp Ser Ile Ser Gly Gly Thr Ala Glu Pro Val Pro Asp Asn Asp Phe
            180                 185                 190         
Leu Leu Pro Asp Leu Ser Arg Lys Gln Asp Gln Glu Lys Ile Ile Pro
        195                 200                 205             
Glu Thr Ser Leu Phe Glu Glu Lys Gly Glu Glu Lys Asn Val Ser Arg
    210                 215                 220                 
Ser Lys Arg Ser Leu Ala Val Asn Pro Leu Leu Asp Thr Asp Asp Asp
225                 230                 235                 240 
Gly Ile Tyr Asp Glu Trp Glu Thr Asn Gly Tyr Thr Ile Gln Gly Gln
                245                 250                 255     
Leu Ala Val Arg Trp Asn Asn Ser Met Lys Glu Gln Asn Tyr Pro Lys
            260                 265                 270         
Tyr Val Ser Asn Pro Tyr Lys Ser His Thr Val Ala Asp Pro Tyr Thr
        275                 280                 285             
Asp Trp Glu Lys Ala Ser Gly Arg Ile Asp Gln Ala Val Lys Arg Glu
    290                 295                 300                 
Ala Lys Asn Pro Leu Val Ala Ala Tyr Pro Val Val Gly Val Asn Met
305                 310                 315                 320 
Glu Arg Leu Ile Val Ser Glu Asn Gln Asn Ile Ser Thr Gly Leu Gly
                325                 330                 335     
Arg Thr Val Thr Ala Ser Thr Ser Ala Ser Ser Thr Ala Gly Ile Thr
            340                 345                 350         
Ala Gly Ile Asp Ala Thr Val Gly Ala Ser Leu Leu Gly Pro Ser Gly
        355                 360                 365             
Ser Val Thr Ala His Phe Ser Tyr Thr Gly Ser Ser Thr Ala Ala Val
    370                 375                 380                 
Glu Asn Ser Ser Ser Asn Asn Trp Ser Asp Asp Leu Gly Ile Asn Thr
385                 390                 395                 400 
Ala His Ser Ala Tyr Leu Asn Ala Asn Val Arg Tyr Tyr Asn Thr Gly
                405                 410                 415     
Thr Ala Pro Ile Tyr Asn Val Thr Pro Thr Thr Asn Phe Val Leu Asp
            420                 425                 430         
Ser Glu Thr Ile Val Thr Val Arg Ala Lys Glu Asn Gln Leu Gly Asp
        435                 440                 445             
Val Leu Lys Ala Gly Gly Thr Tyr Pro Glu Lys His Leu Asn Pro Ile
    450                 455                 460                 
Ala Leu Asn Thr Leu Asp Asp Phe Gly Ser Gln Leu Ile Pro Ile Asn
465                 470                 475                 480 
Tyr Asp Gln Thr Lys Arg Leu Glu Asn Gly Asn Lys Leu Gln Leu Gln
                485                 490                 495     
Thr Thr Gln Ala Ser Gly Leu Tyr Gly Lys Met Asn Ser Asn Gly Gly
            500                 505                 510         
Leu Asn Ile His Pro Ser Gln Glu Trp Glu Pro Val Arg Ala Gln Ile
        515                 520                 525             
Glu Ser Val Ser Ala Gly Ile Val Leu Asp Thr Gly Glu Glu Val Leu
    530                 535                 540                 
Glu Arg Arg Val Ala Thr Arg Asp Asp Arg Asp Pro Glu Asp Leu Thr
545                 550                 555                 560 
Pro Glu Ile Thr Ile Gly Glu Ala Ile Lys Ile Ala Phe Asp Thr Thr
                565                 570                 575     
Glu Gln Gly Gly Lys Leu Gln Tyr Lys Asp Thr Pro Leu Asn Glu Ser
            580                 585                 590         
Leu Val Glu Leu Ile Val Asp Glu Ser Thr Ala Arg Glu Ile Lys Ala
        595                 600                 605             
Gln Leu Asp Gly Asn Pro Gly Leu Glu Lys Lys Ile Tyr Asn Val Lys
    610                 615                 620                 
Leu Lys Arg Gly Met Asn Ile Met Leu Lys Lys Pro Ile Trp Tyr Ser
625                 630                 635                 640 
Asp Phe Asp Thr His Gln His Asn Trp Ser Asn Ile Thr Ile Ala Pro
                645                 650                 655     
Glu Glu Gly Ile Thr Gly Asn Ala Gly Lys Ile Ser Gln Gly Ser Val
            660                 665                 670         
Gln Pro Ala Phe Leu Arg Tyr Gln Thr Val Glu Asp Phe Lys Asn Leu
        675                 680                 685             
Lys Pro Asn Thr Arg Tyr Lys Leu Ser Ala Ser Ile Arg Tyr Leu Asp
    690                 695                 700                 
Leu Glu Pro Gly Gly Val Thr Gly Ala Tyr Ile Arg Val Asn Asp Leu
705                 710                 715                 720 
Pro Asn Asn Glu Tyr Leu Ile Arg Ser Asn Leu Tyr Glu Arg Ile Glu
                725                 730                 735     
Ser Thr Phe Thr Thr Gly Ile Ile Pro Ser Gly Ile Thr Asp Phe Arg
            740                 745                 750         
Ile Ala Thr Thr Gly Ser Arg Asp Met Leu Leu Asp Asp Ile Thr Leu
        755                 760                 765             
Val Glu Leu Gly Pro Ser Asn
    770                 775 


<210> 57
<211> 672
<212> PRT
<213> Bacillus thuringiensis

<400> 57
Met Lys Asn Met Asn Ser Tyr Gln Asn Lys Asn Lys Asn Glu Tyr Glu
 1               5                  10                  15      
Ile Leu Asp Thr Ser Arg Ser Ser Ser Thr Met Ser Thr Arg Tyr Pro
            20                  25                  30          
Arg Tyr Pro Leu Ala Glu Asn Pro Gln Ile Ser Met Gln Asn Thr Asn
        35                  40                  45              
Tyr Lys Asp Trp Ile Asn Met Cys Ala Ser Arg Asn Leu Glu Asp Gly
    50                  55                  60                  
Ile Tyr Pro Thr Ser Ala Asn Asp Val Ile Thr Asn Ser Ile Asn Ile
65                  70                  75                  80  
Ser Ser Tyr Ile Leu Ser Met Leu Gly Met Pro Asn Leu Ser Ser Ile
                85                  90                  95      
Ile Ala Ile Trp Gly Val Leu Phe Asn Ala Phe Trp Pro Val Ser Gly
            100                 105                 110         
Asn Gln Trp Glu His Tyr Met Asn His Val Gln Ala Leu Ile Lys Arg
        115                 120                 125             
Glu Leu Gln Ala Phe Ala Arg Glu Gln Ala Leu Arg Gln Leu Glu Gly
    130                 135                 140                 
Leu Gly Gly Asn Leu Gly Leu Tyr Lys Glu Ala Leu Ala Glu Trp Glu
145                 150                 155                 160 
Gln Asp Arg Asp Asn Pro Thr Thr Lys Glu Arg Val Arg Asp Arg Phe
                165                 170                 175     
Arg Ile Leu Asp Gly Phe Phe Thr Gln Tyr Ile Pro Val Phe Arg Ile
            180                 185                 190         
Gln Gly Tyr Glu Val Gln Leu Leu Ser Ile Tyr Ala Lys Val Val Asn
        195                 200                 205             
Leu His Leu Leu Leu Leu Arg Asp Ala Ser Met Phe Gly Ala Asp Trp
    210                 215                 220                 
Gly Met Ser Gln Thr Asn Ile Asn Asp Asn Tyr Asn Arg Gln Met Lys
225                 230                 235                 240 
Leu Thr Ser Leu Tyr Thr Asn His Cys Val Asp Phe Tyr Asn Gln Gly
                245                 250                 255     
Leu Asn Glu Ala Arg Ala Leu Ser Asn Ser Ser Trp Asp Ile Phe Asn
            260                 265                 270         
Asp Tyr Arg Arg Glu Met Thr Leu Thr Val Leu Asp Ile Val Ala Leu
        275                 280                 285             
Phe Pro Ala Tyr Asp Tyr Arg Arg Tyr Pro Ile Thr Thr Lys Val Glu
    290                 295                 300                 
Leu Thr Arg Glu Ile Tyr Thr Pro Ala Ile Ala Ser Gln Thr Trp Ser
305                 310                 315                 320 
Asn His Asn His Leu Ser Pro Asn Val Asn Phe Gln Phe Tyr Glu Asn
                325                 330                 335     
Asn Leu Val Arg Pro Pro Ala Phe Phe Thr Trp Leu Asp Arg Thr Glu
            340                 345                 350         
Met Phe Ser Arg Asn Leu Ser Ile Glu Val Ser Glu Ala Trp Gly Gly
        355                 360                 365             
His Ile Asn His Phe His His Thr Gly Glu Gln Pro Leu Ser Ser Arg
    370                 375                 380                 
Ser Gly Phe Ile Gly Ser Asp Gln Arg Arg Val Ser Tyr Tyr Asp Phe
385                 390                 395                 400 
Asn Phe Val Gly Asn Asp Val Phe Arg Ile Tyr Ser Arg Val Met Ser
                405                 410                 415     
Asn Gln Val Gly Asn Phe Phe Gly Val Gly Gln Gly Asp Phe Phe Leu
            420                 425                 430         
Val Asn Ser Asp Asn Ser Asn Thr Lys Thr Ile Ser Phe Thr Thr Arg
        435                 440                 445             
Ala Thr Asn Ser Asn Gln Arg Ser Ile Phe Ser Gln Phe Pro Gly Glu
    450                 455                 460                 
Asn Ser Asp Pro Pro Thr Ser Lys Asp Tyr Ser His Arg Leu Ser Trp
465                 470                 475                 480 
Ile Ser Gly Ala Phe Ile Gly Ser Asp Leu Ala Asn Val Leu Ser Tyr
                485                 490                 495     
Gly Trp Thr His Arg Ser Val Asp Pro Asn Asn Thr Ile Tyr Pro Asp
            500                 505                 510         
Arg Ile Thr Gln Val Pro Ala Val Lys Ala Ser Ser Ala Pro Asp Cys
        515                 520                 525             
Thr Val Ile Leu Gly Pro Gly Ser Thr Gly Gly Asn Leu Val Ser Phe
    530                 535                 540                 
Gly Arg Ser Gly Arg Leu Asn Met Gln Phe Lys Phe Thr Asn Ile Gln
545                 550                 555                 560 
Thr Glu Tyr Arg Val Arg Ile Arg Tyr Ala Ser Thr Ala Val Asn Thr
                565                 570                 575     
Leu Phe Val Ser Phe Ser Asp Tyr Asn Arg Asp Ile Ala Leu Asn Ser
            580                 585                 590         
Thr Gly Ala Leu Ser Leu Asn Asn Leu Arg Asn Glu Asn Phe Ala Tyr
        595                 600                 605             
Phe Glu Val Pro Gly Gly Ile Phe Arg Pro Ala Leu Gly Asn Thr Leu
    610                 615                 620                 
Ile Ile Ser Asn Trp Thr Thr Val Ala Pro Arg Leu Val Ile Asp Lys
625                 630                 635                 640 
Ile Glu Phe Ile Pro Ile Asn Ala Thr Thr Ala Arg Tyr Gly Ser Lys
                645                 650                 655     
Gln Glu Leu Glu Lys Ala Thr Lys Val Val Asn Asn Leu Phe Ile Asn
            660                 665                 670         


<210> 58
<211> 1225
<212> PRT
<213> Bacillus thuringiensis

<400> 58
Met Ser Pro Asn Asn Gln Asn Glu Tyr Glu Ile Ile Asp Ala Thr Pro
 1               5                  10                  15      
Ser Thr Ser Val Ser Asn Asp Ser Asn Arg Tyr Pro Phe Ala Asn Glu
            20                  25                  30          
Pro Thr Asn Ala Leu Gln Asn Met Asn Tyr Lys Glu Tyr Leu Ser Met
        35                  40                  45              
Ser Glu Gly Tyr Asp Arg Glu Tyr Phe Ala Ser Pro Gly Ala Leu Val
    50                  55                  60                  
Ser Gly Lys Gln Ala Ile Lys Val Gly Ile Asp Ile Val Gly Lys Ile
65                  70                  75                  80  
Leu Gly Ala Leu Gly Ile Pro Phe Val Gly Glu Ile Val Gly Phe Tyr
                85                  90                  95      
Asn Phe Ile Leu Asp Gln Leu Trp Pro Ser Asn Ser Val Ser Ile Trp
            100                 105                 110         
Glu Gln Ile Met Thr Leu Val Glu Glu Leu Val Asp Gln Lys Ile Thr
        115                 120                 125             
Glu Tyr Ala Arg Asn Lys Ala Ile Ala Glu Leu Thr Gly Leu Gly Asn
    130                 135                 140                 
Ala Met Asp Val Tyr Gln Gln Ser Leu Glu Asp Trp Val Ala Asn Pro
145                 150                 155                 160 
Asn Asp Ala Arg Thr Arg Ser Val Val Ala Thr Gln Phe Thr Ala Leu
                165                 170                 175     
Glu Leu Asp Phe Val Gln Ala Ile Pro Ser Phe Ala Ile Ser Gly Gln
            180                 185                 190         
Glu Val Pro Leu Leu Gly Val Tyr Ala Gln Ala Val Asn Leu His Leu
        195                 200                 205             
Leu Leu Leu Arg Asp Ala Ser Ile Phe Gly Glu Glu Trp Gly Phe Ser
    210                 215                 220                 
Ser Ser Glu Ile Ser Arg Tyr Tyr Asn Arg Gln Val Gln Leu Thr Ser
225                 230                 235                 240 
Gln Tyr Ser Asp Tyr Cys Val Lys Trp Tyr Asn Thr Gly Leu Gln Lys
                245                 250                 255     
Leu Lys Gly Thr Ser Ala Glu Asn Trp Leu Glu Tyr His Gln Phe Arg
            260                 265                 270         
Arg Glu Met Thr Phe Met Val Leu Asp Leu Val Ala Leu Phe Pro Asn
        275                 280                 285             
Tyr Asn Thr His Met Tyr Pro Leu Glu Thr Lys Ala Gln Leu Thr Arg
    290                 295                 300                 
Glu Val Tyr Thr Asp Pro Ile Ala Phe Asn Leu Ser Gly Ala Ala Gly
305                 310                 315                 320 
Phe Cys Ser Pro Trp Ser Lys Tyr Thr Gly Ile Ser Phe Ser Glu Ile
                325                 330                 335     
Glu Asn Ala Val Ile Arg Pro Pro His Leu Phe Asn Val Leu Arg Ser
            340                 345                 350         
Leu Glu Ile Asn Thr Val Arg Gly Thr Ile Leu Gly Asn Thr Lys Asp
        355                 360                 365             
Phe Gln Asn Tyr Trp Ser Gly His Ser Leu Arg Tyr Asn Phe Ile Gly
    370                 375                 380                 
Asn Thr Thr Ile Ser Glu Ser Asn Tyr Gly Tyr Leu Thr Ser Glu Lys
385                 390                 395                 400 
Thr Arg Ile Glu Leu Asp Thr Arg Asp Ile Phe Glu Ile Asn Ser Thr
                405                 410                 415     
Ala Ala Asn Leu Ala Asn Tyr Tyr Gln Gln Val Tyr Gly Val Pro Gln
            420                 425                 430         
Ser Gly Phe His Met Val Arg Trp Asp Ser Pro Tyr Asn Thr Ser Thr
        435                 440                 445             
Gln Leu Tyr Ser Lys Thr Tyr Thr Thr Pro Lys Asp Cys Thr Gln Val
    450                 455                 460                 
Tyr Gln Ser Ser Glu Glu Ile Pro Val Glu Arg Thr Val Pro Val Asn
465                 470                 475                 480 
Glu Gly Tyr Ser His Arg Leu Ser Tyr Val Thr Ser Phe Asp Phe Ser
                485                 490                 495     
Lys Ile Ile Asn Ser Phe Val Arg Asn Gly Asn Leu Pro Val Phe Val
            500                 505                 510         
Trp Thr His Arg Ser Ala Asp Leu Thr Asn Thr Ile Tyr Pro Asp Val
        515                 520                 525             
Ile Thr Gln Ile Pro Val Val Lys Ala Tyr Ala Leu Gly Ser Ser Ile
    530                 535                 540                 
Leu Pro Gly Ser Pro Ser Pro Thr Ile Val Pro Gly Pro Gly Phe Thr
545                 550                 555                 560 
Gly Gly Asp Ile Ile Gln Leu Leu Ala Asn Thr Lys Gly Ile Ala Tyr
                565                 570                 575     
Met Asn Phe Glu Ile Gln Asp Ile Asn Lys Glu Tyr Ile Met Arg Ile
            580                 585                 590         
Arg Tyr Ala Ser Ala Ala Asn Pro Glu Phe Asn Ile Ala Val Gly Thr
        595                 600                 605             
Ser Gly Glu Arg Val Ser Thr Ser Ala Gln Lys Thr Met Asn Pro Gly
    610                 615                 620                 
Asp Ile Leu Thr Phe Asn Lys Phe Asn Tyr Ala Thr Phe Pro Pro Ile
625                 630                 635                 640 
Lys Phe Asn Ser Thr Lys Ile Ser Ile Ala Leu Thr Ala Ser Leu Ala
                645                 650                 655     
Ala Phe Ala Ser Thr Leu Leu Glu Thr Tyr Ile Asp Arg Ile Glu Phe
            660                 665                 670         
Ile Pro Val Asp Glu Thr Tyr Glu Ala Glu Ala Asp Leu Glu Ala Ala
        675                 680                 685             
Lys Lys Ala Val Asn Ala Leu Phe Thr Asn Thr Lys Asp Gly Leu Arg
    690                 695                 700                 
Pro Gly Val Thr Asp Tyr Glu Val Asn Gln Ala Ala Asn Leu Val Glu
705                 710                 715                 720 
Cys Leu Ser Asp Asp Leu Tyr Pro Asn Glu Lys Arg Leu Leu Phe Asp
                725                 730                 735     
Ala Val Arg Glu Ala Lys Arg Leu Ser Glu Ala Arg Asn Leu Leu Gln
            740                 745                 750         
Asp Pro Asp Phe Gln Glu Ile Asn Gly Glu Asn Gly Trp Thr Ala Ser
        755                 760                 765             
Thr Gly Val Glu Ile Ile Glu Gly Asp Ala Val Phe Lys Gly Arg Tyr
    770                 775                 780                 
Leu Arg Leu Pro Gly Ala Arg Glu Ile Asp Thr Glu Thr Tyr Pro Thr
785                 790                 795                 800 
Tyr Val Tyr Gln Lys Ile Glu Glu Gly Val Leu Lys Pro Tyr Thr Arg
                805                 810                 815     
Tyr Arg Leu Arg Gly Phe Val Gly Ser Ser Gln Gly Leu Glu Ile Phe
            820                 825                 830         
Thr Ile Arg His Gln Thr Asn Arg Ile Val Lys Asn Val Pro Asp Asp
        835                 840                 845             
Leu Leu Pro Asp Val Pro Pro Val Asn Ser Asp Gly Arg Ile Asn Arg
    850                 855                 860                 
Cys Ser Glu Gln Lys Tyr Val Asn Ser Arg Leu Glu Gly Glu Arg Gly
865                 870                 875                 880 
Leu Pro Asn Gly Asn Arg Ser Ala Glu Ala His Glu Phe Ser Leu Pro
                885                 890                 895     
Ile Asp Ile Gly Glu Leu Asp Tyr Asn Glu Asn Ala Gly Ile Trp Val
            900                 905                 910         
Gly Phe Lys Ile Thr Asp Pro Glu Gly Tyr Ala Thr Leu Gly Asn Leu
        915                 920                 925             
Glu Leu Val Glu Glu Gly Pro Leu Ser Gly Asp Ala Leu Glu Arg Leu
    930                 935                 940                 
Gln Arg Glu Glu Gln Gln Trp Lys Leu Gln Met Thr Lys Arg Arg Glu
945                 950                 955                 960 
Glu Thr Asp Arg Lys Tyr Met Ala Ala Lys Gln Ala Val Asp Arg Leu
                965                 970                 975     
Tyr Ala Asp Tyr Gln Asp Gln Gln Leu Asn Pro Asn Val Glu Ile Thr
            980                 985                 990         
Asp Ile Thr Ala Ala Gln Asp Leu Ile Gln Ser Ile Pro Tyr Val Tyr
        995                 1000                1005            
Asn Glu Ile Phe Pro Glu Ile Gln Gly Met Asn Tyr Ala Lys Phe Thr
    1010                1015                1020                
Glu Leu Ser Asn Arg Leu Gln Arg Ala Trp Gly Leu Tyr Asp Gln Arg
1025                1030                1035               1040 
Asn Ala Ile Pro Asn Gly Asp Phe Arg Asn Gly Leu Ser Asn Trp Asn
                1045                1050                1055    
Thr Thr Pro Gly Val Glu Val Gln Gln Ile Asn Asp Thr Ser Val Leu
            1060                1065                1070        
Val Ile Pro Asn Trp Asp Glu Gln Val Ser Gln Gln Phe Thr Val Gln
        1075                1080                1085            
Pro Asn Gln Arg Tyr Val Leu Arg Val Thr Ala Arg Lys Glu Gly Val
    1090                1095                1100                
Gly Asn Gly Tyr Val Ser Ile Arg Asp Gly Gly Asn Gln Thr Glu Thr
1105                1110                1115               1120 
Leu Thr Phe Ser Ala Ser Asp Tyr Asp Thr Asn Asn Val Tyr Asn Thr
                1125                1130                1135    
Gln Ala Ser Asn Thr Asn Gly Tyr Asn Thr Asn Asn Ala Tyr Asn Thr
            1140                1145                1150        
Gln Val Ser Asn Thr Asn Gly Tyr Asn Thr Asn Asn Ala Tyr Asn Thr
        1155                1160                1165            
Asn Gly Tyr Asn Thr Gln Ala Ser Asn Thr Asn Gly Leu Tyr Asn Glu
    1170                1175                1180                
Gln Thr Gly Tyr Ile Thr Lys Thr Val Thr Phe Ile Pro Tyr Thr Glu
1185                1190                1195               1200 
Gln Val Trp Ile Glu Met Ser Glu Thr Glu Gly Thr Phe Tyr Ile Glu
                1205                1210                1215    
Ser Val Glu Leu Ile Val Asp Val Glu
            1220                1225


<210> 59
<211> 1184
<212> PRT
<213> Bacillus thuringiensis

<400> 59
Met Cys Phe Leu Cys His Arg Arg His Ile Gly Asp Cys Leu Phe Asn
 1               5                  10                  15      
Leu Ile Tyr Phe Leu Glu Val Asn Tyr Met Asp Ile Arg Asn Gln Lys
            20                  25                  30          
Lys Ser Glu Glu Ile His Pro Thr Leu Asn Glu Ser Ser Ser Asn Thr
        35                  40                  45              
Thr Ser Lys Tyr Pro Leu Ala Ser Asp Leu Ile Lys Gln Tyr Gln Asn
    50                  55                  60                  
Met Asn Tyr Lys Asp Ser Leu Asn Ile Ile Glu Glu Asn Asn Val Ile
65                  70                  75                  80  
Asp Pro Val Ser Gly Thr Ala Ala Leu Val Thr Ala Arg Lys Ile Gly
                85                  90                  95      
Gly Lys Ile Ile Lys Lys Leu Gly Glu Ala Ala Leu Ser Lys Ile Leu
            100                 105                 110         
Lys Glu Ile Leu Gly Tyr Leu Trp Pro Thr Ser Gly Glu Asp Asp Ser
        115                 120                 125             
Trp Thr Asp Met Met Thr Ala Val Glu Glu Leu Ile Asp Gln Lys Ile
    130                 135                 140                 
Gln Glu Gln Val Glu Leu Asp Ala Leu Thr Glu Leu Glu Lys Ile Gly
145                 150                 155                 160 
Glu Ala Val Glu Ala Tyr Tyr Ile Ala Leu Asp Asp Trp Glu Pro Val
                165                 170                 175     
Pro Glu Asp Met Phe Ser Leu Ser Glu Val Ile Lys Arg Tyr Asp Phe
            180                 185                 190         
Ala Gln Gln Leu Ala Arg Ala Ser Met Pro Glu Phe Lys Lys Lys Gly
        195                 200                 205             
Tyr Glu Ile Pro Leu Leu Ala Thr Tyr Ala Asn Ala Ala Asn Val His
    210                 215                 220                 
Leu Leu Leu Met Arg Asp Met Gln Ile Tyr Gly Glu Arg Trp Gly Ile
225                 230                 235                 240 
Pro Lys Glu Asp Ile Glu Leu Tyr Leu Ser Glu Gln Glu Asn Phe Thr
                245                 250                 255     
Ser Glu Tyr Thr Asp His Cys Val Lys Tyr Tyr Asn Glu Gly Leu Asn
            260                 265                 270         
Gln Leu Lys Asn Lys Ser Gly Val Ser Gly Leu Val Trp Glu Asn Tyr
        275                 280                 285             
Asn Arg Phe Arg Thr Glu Met Thr Ile Leu Val Leu Asp Ile Val Ala
    290                 295                 300                 
Val Phe Pro Arg Tyr Asn Val Ile Glu Tyr Pro Ile Asp Ser Thr Val
305                 310                 315                 320 
Glu Leu Thr Arg Thr Ile Tyr Leu Asp Pro Leu Gly Tyr Thr Gly Asn
                325                 330                 335     
Ser Asn Asp Glu His Pro Glu Tyr Tyr Ala Ser Thr Lys Ser Phe Ser
            340                 345                 350         
Ser Ile Glu Ser Arg Ala Ile Pro Ala Pro Thr Leu Phe Gln Trp Ile
        355                 360                 365             
Thr Glu Leu Gln Val Tyr Ser Ala Lys Gly Ser His Gly Ser Thr Tyr
    370                 375                 380                 
Thr Thr Trp Trp Thr Gly His Lys Val Thr Ala Lys Pro Thr Asn Gly
385                 390                 395                 400 
Gly Leu Glu Ser Lys Tyr Asp Phe Gly Ser Ser Ser Gly Ser Gln Asn
                405                 410                 415     
Lys Asp Val Phe Ala Leu Asp Gly Lys Asp Val Tyr Asp Ser Gln Ser
            420                 425                 430         
Met Leu Thr Ser Ile Ser Tyr Ser Gly Ile Arg Tyr Phe Gly Cys Pro
        435                 440                 445             
Gln Phe Lys Leu Asn Trp Ile Asn Lys Asn Asn Glu Leu Ala Glu Gln
    450                 455                 460                 
Ile Phe Asn Tyr Ser Ser Asn Val Gly Ser Ser Phe Ser Glu Tyr Arg
465                 470                 475                 480 
Tyr Ser Lys Asp Glu Leu Pro Ile Glu Leu Leu Ala Ser Pro Ile Tyr
                485                 490                 495     
Gly Asp Ile Glu Glu Tyr Ser His Arg Leu Ser His Val Ser Glu Val
            500                 505                 510         
Ile Lys Asp Tyr Gly Gln Gly Ile Ile Pro Val Leu Gly Phe Thr His
        515                 520                 525             
Val Ser Val Ser Arg Asp Asn Arg Ile Tyr Ser Asp Lys Ile Thr Gln
    530                 535                 540                 
Ile Pro Ala Val Lys Met Tyr Glu Leu Val Ser Pro Ala Val Val Val
545                 550                 555                 560 
Lys Gly Pro Gly Ser Thr Gly Gly Asp Leu Val Lys Arg Gly Ser Ser
                565                 570                 575     
Gly Asn Ile Gly Ser Met Asn Val Thr Val Asn Ser Pro Leu Ser Gln
            580                 585                 590         
Lys Tyr Arg Val Arg Val Arg Tyr Ala Thr Asn Ala Ser Gly Gln Leu
        595                 600                 605             
Asn Val Ser Ile Asn Asp Lys Leu Thr Leu Gln Lys Pro Phe Glu Arg
    610                 615                 620                 
Thr Gly Thr Thr Ile Gly Glu Gly Thr Asp Leu Ser Tyr Asp Ser Phe
625                 630                 635                 640 
Gly Tyr Leu Glu Tyr Ser Thr Thr Ile Gln Phe Pro Asn Glu His Pro
                645                 650                 655     
Lys Ile Thr Phe Asn Leu Ser His Trp Ser Gly Ser Gly Ala Phe Tyr
            660                 665                 670         
Ile Asp Lys Ile Glu Phe Ile Pro Val Asp Glu Asn Tyr Asp Glu Arg
        675                 680                 685             
Val Thr Leu Glu Lys Ala Gln Lys Ala Val Asn Ala Leu Phe Thr Ala
    690                 695                 700                 
Gly Arg Asn Ala Leu Gln Lys Asp Val Thr Asp Phe Lys Val Asp Gln
705                 710                 715                 720 
Val Ser Ile Leu Val Asp Cys Ile Pro Gly Glu Leu Tyr Pro Asn Glu
                725                 730                 735     
Lys Arg Glu Leu Leu Ser Leu Val Lys Tyr Ala Lys Arg Leu Ser Tyr
            740                 745                 750         
Ser Arg Asn Leu Leu Leu Asp Pro Thr Phe Asp Ser Ile Asn Ser Pro
        755                 760                 765             
Asp Glu Asn Gly Trp Tyr Gly Ser Asn Gly Ile Ala Ile Gly Asn Gly
    770                 775                 780                 
Asn Phe Val Phe Lys Gly Asn Tyr Leu Ile Phe Ser Gly Thr Asn Asp
785                 790                 795                 800 
Thr Gln Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu
                805                 810                 815     
Lys Glu Tyr Thr Arg Tyr Lys Leu Arg Gly Phe Ile Glu Ser Ser Gln
            820                 825                 830         
Asp Leu Glu Ala Tyr Val Ile Arg Tyr Asp Ala Lys His Glu Thr Leu
        835                 840                 845             
Asp Val Ser Asn Asn Leu Phe Pro Asp Ile Ser Pro Val Asn Ala Cys
    850                 855                 860                 
Gly Glu Pro Asn Arg Cys Ala Ala Leu Gln Tyr Leu Asp Glu Asn Pro
865                 870                 875                 880 
Arg Leu Glu Cys Ser Ser Ile Gln Asp Gly Ile Leu Ser Asp Ser His
                885                 890                 895     
Ser Phe Ser Leu Asn Ile Asp Thr Gly Ser Ile Asp Tyr Asp Glu Asn
            900                 905                 910         
Val Gly Ile Trp Val Leu Phe Lys Ile Ser Thr Pro Glu Gly Tyr Ala
        915                 920                 925             
Lys Phe Gly Asn Leu Glu Val Ile Glu Asp Gly Leu Val Ile Gly Glu
    930                 935                 940                 
Ala Leu Ala Arg Val Lys Arg Gln Glu Thr Lys Trp Arg Asn Lys Leu
945                 950                 955                 960 
Thr Gln Leu Arg Thr Glu Thr Gln Ala Ile Tyr Thr Arg Ala Lys Gln
                965                 970                 975     
Ala Ile Asp Asn Leu Phe Thr Asn Ala Gln Asp Ser His Leu Lys Ile
            980                 985                 990         
Gly Ala Thr Phe Ala Ser Ile Val Ala Ala Arg Lys Ile Val Gln Ser
        995                 1000                1005            
Ile Arg Glu Ala Tyr Met Ser Trp Leu Ser Ile Val Pro Ser Val Asn
    1010                1015                1020                
Tyr Pro Ile Phe Thr Glu Leu Asn Glu Arg Val Gln Arg Ala Phe Arg
1025                1030                1035               1040 
Leu Tyr Asp Val Arg Asn Val Val Arg Asn Gly Arg Phe Leu Ser Gly
                1045                1050                1055    
Val Ser Asp Trp Ile Val Thr Ser Asp Val Lys Val Gln Glu Glu Asn
            1060                1065                1070        
Gly Asn Asn Val Leu Val Leu Ser Asn Trp Asp Ala Gln Val Leu Gln
        1075                1080                1085            
Cys Leu Asn Leu Tyr Glu Asp His Gly Tyr Ile Leu Arg Val Thr Ala
    1090                1095                1100                
Arg Lys Glu Gly Leu Gly Glu Gly Tyr Ile Thr Ile Thr Asp Glu Glu
1105                1110                1115               1120 
Gly His Thr Asp Gln Leu Thr Phe Gly Gly Cys Glu Glu Ile Asp Ser
                1125                1130                1135    
Ser Asn Ser Phe Val Ser Thr Gly Tyr Ile Thr Lys Glu Leu Glu Phe
            1140                1145                1150        
Phe Pro Asp Thr Glu Lys Val Arg Ile Glu Ile Gly Glu Thr Glu Gly
        1155                1160                1165            
Thr Phe Gln Val Glu Ser Val Glu Leu Phe Leu Met Glu Asp Ile Cys
    1170                1175                1180                


<210> 60
<211> 1102
<212> PRT
<213> Bacillus thuringiensis

<400> 60
Met Asn Tyr Lys Glu Tyr Leu Asn Ile Thr Glu Gly Gly Ile Ile Asn
 1               5                  10                  15      
Pro Thr Leu Ala Gly Ser Ala Ile Val Val Ala Gln Asn Val Ser Lys
            20                  25                  30          
Thr Ile Leu Lys Lys Leu Gly Ser Thr Ile Leu Gly Lys Ile Leu Gly
        35                  40                  45              
Ser Val Leu Asp Ile Leu Trp Pro Thr Asn Thr Glu Glu Ile Trp Leu
    50                  55                  60                  
Glu Leu Ile Asp Glu Val Glu Glu Leu Ile Asn Gln Lys Ile Glu Gln
65                  70                  75                  80  
Gln Val Ile Ile Asp Ala Glu Thr Ala Leu Glu Ser Val Lys Leu Asn
                85                  90                  95      
Val Asp Leu Tyr Leu Asn Ala Phe Glu Glu Trp Glu Lys Arg Pro Thr
            100                 105                 110         
Asn Glu Tyr Ser Thr Glu Leu Val Tyr Lys Arg Phe Thr Asp Ala Tyr
        115                 120                 125             
Asn Tyr Ala Arg Thr Ser Ile Pro Phe Phe Arg Val Lys Thr Tyr Glu
    130                 135                 140                 
Val Ser Leu Leu Ser Val Tyr Ala Gln Ala Ala Asn Ile Ser Leu Leu
145                 150                 155                 160 
Leu Ser Arg Asp Ala Gln Ile Tyr Gly Asp Leu Trp Gly Phe Asp Glu
                165                 170                 175     
His Asp Lys Ala Thr Phe Asp Ser Glu Arg Lys Leu Phe Arg Ala Glu
            180                 185                 190         
Tyr Ile Asp His Cys Thr Lys Tyr Tyr Lys Val Gly Leu Asp Arg Leu
        195                 200                 205             
Lys Gly Ser Ser Tyr Gly Ser Trp Val Asn Tyr Asn Arg Tyr Arg Arg
    210                 215                 220                 
Glu Met Thr Leu Met Ile Leu Asp Thr Ile Ala Ala Phe Pro Tyr Tyr
225                 230                 235                 240 
Asp Ile Glu Glu Tyr Pro Ile Glu Val Ser Thr Gln Leu Ala Arg Glu
                245                 250                 255     
Val Tyr Thr Asp Pro Ile Ile Thr Ser Phe Val Glu Ser Asp His Gly
            260                 265                 270         
Pro Ser Phe Ser Phe Met Glu Ser Asn Ala Ile Arg Lys Pro His Leu
        275                 280                 285             
Val Asp Tyr Leu Asp Asn Leu Tyr Ile Tyr Thr Ser Arg Phe Arg Thr
    290                 295                 300                 
Phe Ser Asn Glu Phe Gln Pro Asp Leu Asn Tyr Trp Ala Ala His Lys
305                 310                 315                 320 
Val Lys Tyr Lys Tyr Ser Gly Asp Pro Thr Leu His Glu Thr Pro Ile
                325                 330                 335     
Tyr Gly Asn Ala Ser Asn Tyr Glu Ser Thr Gly Asn Tyr Ser Phe Arg
            340                 345                 350         
Gly Asn Ser Ile Tyr Gln Thr Leu Ser Ala Pro Ser Ala Ile Leu Thr
        355                 360                 365             
Pro Asn Tyr Ile Tyr Tyr Gly Ile Glu Gln Val Glu Phe Tyr Gly Asn
    370                 375                 380                 
Lys Gly Asn Val Tyr Tyr Arg Gly Gly Asn Lys Tyr Pro Leu Ser Val
385                 390                 395                 400 
Asp Ser Ala Asn Gln Leu Pro Pro Asp Val Glu Pro Ile Thr Glu Asn
                405                 410                 415     
Tyr Asn His Val Leu Cys His Ala Thr Ala Val Pro Val Lys Asp Gly
            420                 425                 430         
Gly Thr Val Pro Ile Phe Ser Trp Thr His Arg Ser Ala Asp Tyr Tyr
        435                 440                 445             
Asn Thr Ile Tyr Pro Asp Lys Ile Thr Gln Leu Pro Ala Val Lys Ser
    450                 455                 460                 
Thr Pro Ser Pro Glu Val Glu Gly Leu Lys Val Gln Glu Gly Pro Gly
465                 470                 475                 480 
Phe Thr Gly Gly Asp Leu Val Val Ala Lys Ser Ser Asn Gln Thr Ile
                485                 490                 495     
Val Arg Leu Lys Val Thr Val Asp Ser Pro Gly Thr Gln Lys Tyr Arg
            500                 505                 510         
Ile Arg Leu Lys Tyr Ala Ala Thr Ser Asn Phe Tyr Leu Gly Ala Tyr
        515                 520                 525             
Ala Gly Ser Asn Gly Gly Asn Gly Ile Pro Gly Ile Ser Thr Val Pro
    530                 535                 540                 
Lys Thr Met Asn Ile Glu Asp Pro Leu Ser Tyr Thr Ser Phe Ala Tyr
545                 550                 555                 560 
Ile Asp Leu Pro Asp Ser Tyr Thr Phe Ser Gln Lys Asp Glu Val Ile
                565                 570                 575     
Arg Phe Thr Ile Asn Ile Tyr Glu Ser Gly Gly Ala Val Tyr Ala Asp
            580                 585                 590         
Lys Val Glu Phe Ile Pro Val Asp Ala Asp Tyr Asp Glu Gly Val Gln
        595                 600                 605             
Leu Glu Lys Ala Gln Lys Ala Val Asn Ala Leu Phe Thr Ala Gly Arg
    610                 615                 620                 
Asn Ala Leu Gln Thr Asp Val Thr Asp Tyr Lys Val Asp Gln Val Ser
625                 630                 635                 640 
Ile Leu Val Asp Cys Val Ser Gly Glu Leu Tyr Pro Asn Glu Lys Arg
                645                 650                 655     
Glu Leu Gln Asn Leu Ile Lys Tyr Ala Lys Arg Leu Ser Tyr Ser Arg
            660                 665                 670         
Asn Leu Leu Leu Asp Pro Thr Phe Asp Ser Ile Asn Ser Ser Asp Glu
        675                 680                 685             
Asn Gly Trp Tyr Gly Ser Asn Gly Ile Ala Ile Gly Ser Gly Asn Ile
    690                 695                 700                 
Val Phe Lys Gly Asn Tyr Leu Ile Phe Ser Gly Thr Asn Asp Glu Gln
705                 710                 715                 720 
Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Glu
                725                 730                 735     
Tyr Thr Arg Tyr Lys Leu Arg Gly Phe Ile Glu Ser Ser Gln Asp Leu
            740                 745                 750         
Glu Ala Tyr Val Ile Arg Tyr Asp Ala Lys His Gln Thr Met Asp Val
        755                 760                 765             
Ser Asn Asn Leu Phe Ser Asp Ile Thr Pro Val Asn Ala Cys Gly Glu
    770                 775                 780                 
Pro Asn Arg Cys Ala Ala Leu Pro Tyr Leu Asp Glu Asn Pro Arg Leu
785                 790                 795                 800 
Glu Cys Ser Ser Ile Gln Asp Gly Ile Leu Ser Asp Ser His Ser Phe
                805                 810                 815     
Ser Leu His Ile Asp Thr Gly Ser Ile Asp Phe Asn Glu Asn Val Gly
            820                 825                 830         
Ile Trp Val Leu Phe Lys Ile Ser Thr Leu Glu Gly Tyr Ala Lys Phe
        835                 840                 845             
Gly Asn Leu Glu Val Ile Glu Asp Gly Pro Val Ile Gly Glu Ala Leu
    850                 855                 860                 
Ala Arg Val Lys Arg Gln Glu Thr Lys Trp Arg Asn Lys Leu Thr Gln
865                 870                 875                 880 
Leu Arg Thr Glu Thr Gln Ala Ile Tyr Thr Arg Ala Lys Gln Ala Ile
                885                 890                 895     
Asp Asn Leu Phe Thr Asn Glu Gln Asp Ser His Leu Lys Ile Gly Thr
            900                 905                 910         
Thr Phe Ala Leu Ile Val Ala Ala Arg Lys Ile Val Gln Ser Ile Arg
        915                 920                 925             
Glu Ala Tyr Met Ser Trp Leu Ser Ile Val Pro Gly Val Asn Tyr Pro
    930                 935                 940                 
Ile Phe Thr Glu Leu Asn Glu Arg Val Gln Gln Ala Phe Gln Leu Tyr
945                 950                 955                 960 
Asp Val Arg Asn Val Val Arg Asn Gly Arg Phe Gln Ser Gly Thr Ser
                965                 970                 975     
Asp Trp Ile Val Thr Ser Asp Val Lys Val Gln Glu Glu Asn Gly Asn
            980                 985                 990         
Asn Val Leu Val Leu Ser Asn Trp Asp Ala Gln Val Leu Gln Cys Met
        995                 1000                1005            
Thr Leu Tyr Gln Asp Arg Gly Tyr Ile Leu Arg Val Thr Ala Arg Lys
    1010                1015                1020                
Glu Gly Leu Gly Glu Gly Tyr Val Thr Ile Thr Asp Glu Glu Gly Asn
1025                1030                1035               1040 
Thr Asp Gln Leu Arg Phe Gly Gly Cys Glu Glu Ile Asp Ala Ser Asn
                1045                1050                1055    
Ser Phe Val Ser Thr Gly Tyr Val Thr Lys Glu Leu Glu Phe Phe Pro
            1060                1065                1070        
Asp Thr Glu Lys Val Arg Ile Glu Ile Gly Glu Thr Glu Gly Ile Phe
        1075                1080                1085            
Gln Val Gly Ser Val Glu Leu Phe Leu Met Glu Asp Leu Cys
    1090                1095                1100        


<210> 61
<211> 1131
<212> PRT
<213> Bacillus thuringiensis

<400> 61
Met Asn Gln Lys Asn Tyr Glu Ile Ile Gly Ala Ser Thr Asn Gly Thr
 1               5                  10                  15      
Ile Glu Leu Pro Glu Asp Tyr Asn Thr Ile Val Ser Pro Tyr Asp Ala
            20                  25                  30          
Pro Ala Ser Val Thr Thr Thr Ile Glu Ile Thr Gly Thr Ile Leu Ser
        35                  40                  45              
Asp Leu Gly Val Pro Gly Ala Ser Ser Val Ser Leu Leu Leu Asn Lys
    50                  55                  60                  
Leu Ile Asn Leu Leu Trp Pro Asn Asp Thr Asn Thr Val Trp Gly Thr
65                  70                  75                  80  
Phe Gly Lys Glu Thr Ala Asp Leu Leu Asn Glu Val Leu Ser Pro Asp
                85                  90                  95      
Asp Pro Val Val Lys Asp Ala Asn Thr Ile Leu Lys Gly Ile Asn Gly
            100                 105                 110         
Ser Leu Asn Leu Tyr Leu Asn Ala Leu Glu Ile Trp Lys Lys Asp Pro
        115                 120                 125             
Asn Asn Leu Thr Thr Ile Glu Asn Val Thr Asp Tyr Phe Arg Ser Leu
    130                 135                 140                 
Asn Val Val Phe Thr His Asp Met Pro Ser Phe Ala Val Pro Gly Tyr
145                 150                 155                 160 
Glu Thr Lys Leu Leu Thr Ile Tyr Ala Gln Ala Ala Asn Leu His Leu
                165                 170                 175     
Leu Leu Leu Arg Asp Ala Ser Arg Phe Gly Glu Gly Trp Gly Leu Thr
            180                 185                 190         
Gln Glu Ile Ile Asn Thr Asn Tyr Asn Asp Gln Leu Arg Leu Thr Ala
        195                 200                 205             
Glu Tyr Thr Asp His Cys Val Lys Trp Tyr Asn Ala Gly Leu Glu Lys
    210                 215                 220                 
Leu Lys Gly Asn Leu Thr Gly Glu Asn Trp Tyr Thr Tyr Asn Arg Phe
225                 230                 235                 240 
Arg Arg Glu Met Thr Leu Met Val Leu Asp Val Val Ala Leu Phe Pro
                245                 250                 255     
Asn Tyr Asp Thr Arg Met Tyr Pro Ile Gly Thr Ser Ser Glu Leu Thr
            260                 265                 270         
Arg Met Ile Tyr Thr Asp Pro Ile Ala Tyr Thr Gln Ser Asp Pro Trp
        275                 280                 285             
Tyr Lys Ile Thr Ser Leu Ser Phe Ser Asn Ile Glu Asn Ser Ala Ile
    290                 295                 300                 
Pro Ser Pro Ser Phe Phe Arg Trp Leu Lys Ser Val Ser Ile Asn Ser
305                 310                 315                 320 
Gln Trp Trp Gly Ser Gly Pro Ser Gln Thr Tyr Tyr Trp Val Gly His
                325                 330                 335     
Glu Leu Val Tyr Ser Asn Ser Asn Ser Asn Gln Ser Leu Lys Val Lys
            340                 345                 350         
Tyr Gly Asp Pro Asn Ser Phe Ile Glu Pro Pro Asp Ser Phe Ser Phe
        355                 360                 365             
Ser Ser Thr Asp Val Tyr Arg Thr Ile Ser Val Val Arg Asn Ser Val
    370                 375                 380                 
Ser Asn Tyr Ile Val Ser Glu Val Arg Phe Asn Ser Ile Ser Ser Thr
385                 390                 395                 400 
Asn Gln Ile Ser Glu Glu Ile Tyr Lys His Gln Ser Asn Trp Ser Arg
                405                 410                 415     
Gln Glu Thr Lys Asp Ser Ile Thr Glu Leu Ser Leu Ala Ala Asn Pro
            420                 425                 430         
Pro Thr Thr Phe Gly Asn Val Ala Glu Tyr Ser His Arg Leu Ala Tyr
        435                 440                 445             
Ile Ser Glu Ala Tyr Gln Ser His Asn Pro Ser Lys Tyr Pro Thr Tyr
    450                 455                 460                 
Ile Pro Val Phe Gly Trp Thr His Thr Ser Val Arg Tyr Asp Asn Lys
465                 470                 475                 480 
Ile Phe Pro Asp Lys Ile Thr Gln Ile Pro Ala Val Lys Ser Ser Ser
                485                 490                 495     
Ala Gln Gly Gly Ser Trp Lys Asn Ile Val Lys Gly Pro Gly Phe Thr
            500                 505                 510         
Gly Gly Asp Val Thr Thr Ala Val Ser Pro Ala Thr Val Thr Asp Ile
        515                 520                 525             
Ile Lys Ile Gln Val Thr Leu Asp Pro Asn Ser Leu Ser Gln Lys Tyr
    530                 535                 540                 
Arg Ala Arg Leu Arg Tyr Ala Ser Asn Ala Phe Val Pro Ala Thr Leu
545                 550                 555                 560 
Tyr Thr Asn Thr Ser Ser Asn Tyr Asn Phe Glu Leu Lys Lys Gly Thr
                565                 570                 575     
Thr Glu Gln Phe Thr Thr Tyr Asn Ser Tyr Gln Tyr Val Asp Ile Pro
            580                 585                 590         
Gly Ser Ile Gln Phe Asn Asn Thr Ser Asp Thr Val Ser Val Tyr Leu
        595                 600                 605             
His Met Asp Ser Thr Ser Asn Val Asn Val His Val Asp Arg Ile Glu
    610                 615                 620                 
Phe Ile Pro Ile Asp Glu Asn Tyr Asp Glu Arg Phe Gln Leu Glu Lys
625                 630                 635                 640 
Ala Gln Lys Ala Val Asn Ala Leu Phe Thr Ala Gly Arg Asn Ala Leu
                645                 650                 655     
Gln Thr Asp Val Thr Asp Tyr Lys Val Asp Gln Val Ser Ile Leu Val
            660                 665                 670         
Asp Cys Val Ser Gly Glu Leu Tyr Pro Asn Glu Lys Arg Glu Leu Leu
        675                 680                 685             
Ser Leu Val Lys Tyr Ala Lys Arg Leu Ser Tyr Ser Arg Asn Leu Leu
    690                 695                 700                 
Leu Asp Pro Thr Phe Asp Ser Ile Asn Ser Pro Glu Glu Asn Gly Trp
705                 710                 715                 720 
Tyr Gly Ser Asn Gly Ile Ala Ile Gly Ser Gly Asn Ile Val Phe Lys
                725                 730                 735     
Gly Asn Tyr Leu Ile Phe Ser Gly Thr Asn Asp Glu Gln Tyr Pro Thr
            740                 745                 750         
Tyr Leu Tyr Gln Lys Ile Asp Glu Thr Lys Leu Lys Glu Tyr Thr Arg
        755                 760                 765             
Tyr Lys Leu Arg Gly Phe Ile Glu Ser Ser Gln Asp Leu Glu Ala Tyr
    770                 775                 780                 
Val Ile Arg Tyr Asp Ala Lys His Gln Thr Met Asp Val Ser Asn Asn
785                 790                 795                 800 
Leu Phe Ser Asp Ile Thr Pro Val Asn Ala Cys Gly Glu Pro Asn Arg
                805                 810                 815     
Cys Ala Ala Leu Pro Tyr Leu Asp Glu Asn Pro Arg Leu Glu Cys Ser
            820                 825                 830         
Ser Ile Gln Asp Gly Ile Leu Ser Asp Ser His Ser Phe Ser Leu His
        835                 840                 845             
Ile Asp Thr Gly Ser Ile Asp Phe Asn Glu Asn Val Gly Ile Trp Val
    850                 855                 860                 
Leu Phe Lys Ile Ser Thr Pro Glu Gly Tyr Ala Arg Phe Gly Asn Leu
865                 870                 875                 880 
Glu Val Ile Glu Asp Gly Pro Val Ile Gly Glu Ala Leu Ala Arg Val
                885                 890                 895     
Lys Arg Gln Glu Thr Lys Trp Arg Asn Lys Leu Thr Gln Leu Arg Thr
            900                 905                 910         
Glu Thr Gln Ala Ile Tyr Thr Arg Ala Lys Gln Ala Ile Asp Asn Leu
        915                 920                 925             
Phe Thr Asn Ala Gln Asp Ser His Leu Lys Ile Gly Ala Thr Phe Ala
    930                 935                 940                 
Ser Ile Val Ala Ala Arg Lys Ile Val Gln Ser Ile Arg Glu Ala Tyr
945                 950                 955                 960 
Met Ser Trp Leu Ser Ile Val Pro Gly Val Asn Tyr Pro Ile Val Thr
                965                 970                 975     
Glu Leu Asn Glu Arg Ile Gln Gln Ala Phe Gln Leu Tyr Asp Val Arg
            980                 985                 990         
Asn Val Val Arg Asn Gly Arg Phe Gln Ser Gly Thr Ser Asp Trp Ile
        995                 1000                1005            
Val Thr Ser Asp Val Arg Val Gln Glu Glu Asn Gly Asn Asn Val Leu
    1010                1015                1020                
Val Leu Ser Asn Trp Asp Ala Gln Val Leu Gln Cys Met Thr Leu Tyr
1025                1030                1035               1040 
Gln Asp Arg Gly Tyr Ile Leu Arg Val Thr Ala Arg Lys Glu Gly Leu
                1045                1050                1055    
Gly Glu Gly Tyr Val Thr Ile Thr Asp Glu Glu Gly Asn Thr Asp Gln
            1060                1065                1070        
Leu Arg Phe Gly Gly Cys Glu Glu Ile Asp Ala Ser Asn Ser Phe Val
        1075                1080                1085            
Ser Thr Gly Tyr Met Thr Lys Glu Leu Glu Phe Phe Pro Asp Thr Glu
    1090                1095                1100                
Lys Val Arg Ile Glu Ile Gly Glu Thr Glu Gly Thr Phe Gln Val Glu
1105                1110                1115               1120 
Ser Val Glu Leu Phe Leu Met Glu Asp Leu Cys
                1125                1130    


<210> 62
<211> 1206
<212> PRT
<213> Bacillus thuringiensis

<400> 62
Met Ser Pro Asn Asn Gln Asn Glu Tyr Glu Ile Ile Asp Ala Thr Pro
 1               5                  10                  15      
Ser Thr Ser Val Ser Asn Asp Ser Asn Arg Tyr Pro Phe Ala Asn Glu
            20                  25                  30          
Pro Thr Asn Ala Leu Gln Asn Met Asp Tyr Lys Asp Tyr Leu Lys Met
        35                  40                  45              
Ser Ala Gly Asn Ala Ser Glu Tyr Pro Gly Ser Pro Glu Val Leu Val
    50                  55                  60                  
Ser Gly Gln Asp Ala Ala Lys Ala Ala Ile Asp Ile Val Gly Lys Leu
65                  70                  75                  80  
Leu Ser Gly Leu Gly Val Pro Phe Val Gly Pro Ile Val Ser Leu Tyr
                85                  90                  95      
Thr Gln Leu Ile Asp Ile Leu Trp Pro Ser Gly Glu Lys Ser Gln Trp
            100                 105                 110         
Glu Ile Phe Met Glu Gln Val Glu Glu Leu Ile Asn Gln Lys Ile Ala
        115                 120                 125             
Glu Tyr Ala Arg Asn Lys Ala Leu Ser Glu Leu Glu Gly Leu Gly Asn
    130                 135                 140                 
Asn Tyr Gln Leu Tyr Leu Thr Ala Leu Glu Glu Trp Glu Glu Asn Pro
145                 150                 155                 160 
Asn Gly Ser Arg Ala Leu Arg Asp Val Arg Asn Arg Phe Glu Ile Leu
                165                 170                 175     
Asp Ser Leu Phe Thr Gln Tyr Met Pro Ser Phe Arg Val Thr Asn Phe
            180                 185                 190         
Glu Val Pro Phe Leu Thr Val Tyr Ala Met Ala Ala Asn Leu His Leu
        195                 200                 205             
Leu Leu Leu Lys Asp Ala Ser Ile Phe Gly Glu Glu Trp Gly Trp Ser
    210                 215                 220                 
Thr Thr Thr Ile Asn Asn Tyr Tyr Asp Arg Gln Met Lys Leu Thr Ala
225                 230                 235                 240 
Glu Tyr Ser Asp His Cys Val Lys Trp Tyr Glu Thr Gly Leu Ala Lys
                245                 250                 255     
Leu Lys Gly Thr Ser Ala Lys Gln Trp Val Asp Tyr Asn Gln Phe Arg
            260                 265                 270         
Arg Glu Met Thr Leu Ala Val Leu Asp Val Val Ala Leu Phe Pro Asn
        275                 280                 285             
Tyr Asp Thr Arg Thr Tyr Pro Met Glu Thr Lys Ala Gln Leu Thr Arg
    290                 295                 300                 
Glu Val Tyr Thr Asp Pro Leu Gly Ala Val Asn Val Ser Ser Ile Gly
305                 310                 315                 320 
Ser Trp Tyr Asp Lys Ala Pro Ser Phe Gly Val Ile Glu Ser Ser Val
                325                 330                 335     
Ile Arg Pro Pro His Val Phe Asp Tyr Ile Thr Gly Leu Thr Val Tyr
            340                 345                 350         
Thr Gln Ser Arg Ser Ile Ser Ser Ala Arg Tyr Ile Arg His Trp Ala
        355                 360                 365             
Gly His Gln Ile Ser Tyr His Arg Val Ser Arg Gly Ser Asn Leu Gln
    370                 375                 380                 
Gln Met Tyr Gly Thr Asn Gln Asn Leu His Ser Thr Ser Thr Phe Asp
385                 390                 395                 400 
Phe Thr Asn Tyr Asp Ile Tyr Lys Thr Leu Ser Lys Asp Ala Val Leu
                405                 410                 415     
Leu Asp Ile Val Tyr Pro Gly Tyr Thr Tyr Ile Phe Phe Gly Met Pro
            420                 425                 430         
Glu Val Glu Phe Phe Met Val Asn Gln Leu Asn Asn Thr Arg Lys Thr
        435                 440                 445             
Leu Lys Tyr Asn Pro Val Ser Lys Asp Ile Ile Ala Ser Thr Arg Asp
    450                 455                 460                 
Ser Glu Leu Glu Leu Pro Pro Glu Thr Ser Asp Gln Pro Asn Tyr Glu
465                 470                 475                 480 
Ser Tyr Ser His Arg Leu Cys His Ile Thr Ser Ile Pro Ala Thr Gly
                485                 490                 495     
Asn Thr Thr Gly Leu Val Pro Val Phe Ser Trp Thr His Arg Ser Ala
            500                 505                 510         
Asp Leu Asn Asn Thr Ile Tyr Ser Asp Lys Ile Thr Gln Ile Pro Ala
        515                 520                 525             
Val Lys Cys Trp Asp Asn Leu Pro Phe Val Pro Val Val Lys Gly Pro
    530                 535                 540                 
Gly His Thr Gly Gly Asp Leu Leu Gln Tyr Asn Arg Ser Thr Gly Ser
545                 550                 555                 560 
Val Gly Thr Leu Phe Leu Ala Arg Tyr Gly Leu Ala Leu Glu Lys Ala
                565                 570                 575     
Gly Lys Tyr Arg Val Arg Leu Arg Tyr Ala Thr Asp Ala Asp Ile Val
            580                 585                 590         
Leu His Val Asn Asp Ala Gln Ile Gln Met Pro Lys Thr Met Asn Pro
        595                 600                 605             
Gly Glu Asp Leu Thr Ser Lys Thr Phe Lys Val Ala Asp Ala Ile Thr
    610                 615                 620                 
Thr Leu Asn Leu Ala Thr Asp Ser Ser Leu Ala Leu Lys His Asn Leu
625                 630                 635                 640 
Gly Glu Asp Pro Asn Ser Thr Leu Ser Gly Ile Val Tyr Val Asp Arg
                645                 650                 655     
Ile Glu Phe Ile Pro Val Asp Glu Thr Tyr Glu Ala Glu Gln Asp Leu
            660                 665                 670         
Glu Ala Ala Lys Lys Ala Val Asn Ala Leu Phe Thr Asn Thr Lys Asp
        675                 680                 685             
Gly Leu Arg Pro Gly Val Thr Asp Tyr Glu Val Asn Gln Ala Ala Asn
    690                 695                 700                 
Leu Val Glu Cys Leu Ser Asp Asp Leu Tyr Pro Asn Glu Lys Arg Leu
705                 710                 715                 720 
Leu Phe Asp Ala Val Arg Glu Ala Lys Arg Leu Ser Glu Ala Arg Asn
                725                 730                 735     
Leu Leu Gln Asp Pro Asp Phe Gln Glu Ile Asn Gly Glu Asn Gly Trp
            740                 745                 750         
Thr Ala Ser Thr Gly Ile Glu Val Ile Glu Gly Asp Ala Leu Phe Lys
        755                 760                 765             
Gly Arg Tyr Leu Arg Leu Pro Gly Ala Arg Glu Ile Asp Thr Glu Thr
    770                 775                 780                 
Tyr Pro Thr Tyr Leu Tyr Gln Lys Val Glu Glu Gly Val Leu Lys Pro
785                 790                 795                 800 
Tyr Thr Arg Tyr Arg Leu Arg Gly Phe Val Gly Ser Ser Gln Gly Leu
                805                 810                 815     
Glu Ile Phe Thr Ile Arg His Gln Thr Asn Arg Ile Val Lys Asn Val
            820                 825                 830         
Pro Asp Asp Leu Leu Pro Asp Val Ser Pro Val Asn Ser Asp Gly Ser
        835                 840                 845             
Ile Asn Arg Cys Ser Glu Gln Lys Tyr Val Asn Ser Arg Leu Glu Val
    850                 855                 860                 
Glu Asn Arg Ser Gly Glu Ala His Glu Phe Ser Ile Pro Ile Asp Thr
865                 870                 875                 880 
Gly Glu Ile Asp Tyr Asn Glu Asn Ala Gly Ile Trp Val Gly Phe Lys
                885                 890                 895     
Ile Thr Asp Pro Glu Gly Tyr Ala Thr Leu Gly Asn Leu Glu Leu Val
            900                 905                 910         
Glu Glu Gly Pro Leu Ser Gly Asp Ala Leu Glu Arg Leu Gln Arg Glu
        915                 920                 925             
Glu Gln Gln Trp Lys Ile Gln Met Thr Arg Arg Arg Glu Glu Thr Asp
    930                 935                 940                 
Arg Arg Tyr Met Ala Ser Lys Gln Ala Val Asp Arg Leu Tyr Ala Asp
945                 950                 955                 960 
Tyr Gln Asp Gln Gln Leu Asn Pro Asp Val Glu Ile Thr Asp Leu Thr
                965                 970                 975     
Ala Ala Gln Asp Leu Ile Gln Ser Ile Pro Tyr Val Tyr Asn Glu Met
            980                 985                 990         
Phe Pro Glu Ile Pro Gly Met Asn Tyr Thr Lys Phe Thr Glu Leu Thr
        995                 1000                1005            
Asp Arg Leu Gln Gln Ala Trp Ser Leu Tyr Asp Gln Arg Asn Ala Ile
    1010                1015                1020                
Pro Asn Gly Asp Phe Arg Asn Gly Leu Ser Asn Trp Asn Ala Thr Pro
1025                1030                1035               1040 
Gly Val Glu Val Gln Gln Ile Asn His Thr Ser Val Leu Val Ile Pro
                1045                1050                1055    
Asn Trp Asp Glu Gln Val Ser Gln Gln Phe Thr Val Gln Pro Asn Gln
            1060                1065                1070        
Arg Tyr Val Leu Arg Val Thr Ala Arg Lys Glu Gly Val Gly Asn Gly
        1075                1080                1085            
Tyr Val Ser Ile Arg Asp Gly Gly Asn Gln Thr Glu Thr Leu Thr Phe
    1090                1095                1100                
Ser Ala Ser Asp Tyr Asp Thr Asn Gly Met Tyr Asn Thr Gln Val Ser
1105                1110                1115               1120 
Asn Thr Asn Gly Tyr Asn Thr Asn Asn Ala Tyr Asn Thr Gln Ala Ser
                1125                1130                1135    
Ser Thr Asn Gly Tyr Asn Ala Asn Asn Met Tyr Asn Thr Gln Ala Ser
            1140                1145                1150        
Asn Thr Asn Gly Tyr Asn Thr Asn Ser Val Tyr Asn Asp Gln Thr Gly
        1155                1160                1165            
Tyr Ile Thr Lys Thr Val Thr Phe Ile Pro Tyr Thr Asp Gln Met Trp
    1170                1175                1180                
Ile Glu Met Ser Glu Thr Glu Gly Thr Phe Tyr Ile Glu Ser Val Glu
1185                1190                1195               1200 
Leu Ile Val Asp Val Glu
                1205    


<210> 63
<211> 1210
<212> PRT
<213> Bacillus thuringiensis

<400> 63
Met Ser Pro Asn Asn Gln Asn Glu Tyr Glu Ile Ile Asp Ala Thr Pro
 1               5                  10                  15      
Ser Thr Ser Val Ser Asn Asp Ser Asn Arg Tyr Pro Phe Ala Asn Glu
            20                  25                  30          
Pro Thr Asn Ala Leu Gln Asn Met Asp Tyr Lys Asp Tyr Leu Lys Met
        35                  40                  45              
Ser Ala Gly Asn Ala Ser Glu Tyr Pro Gly Ser Pro Glu Val Leu Val
    50                  55                  60                  
Ser Gly Gln Asp Ala Ala Lys Ala Ala Ile Asp Ile Val Gly Lys Leu
65                  70                  75                  80  
Leu Ser Gly Leu Gly Val Pro Phe Val Gly Pro Ile Val Ser Leu Tyr
                85                  90                  95      
Thr Gln Leu Ile Asp Ile Leu Trp Pro Ser Gly Gln Lys Ser Gln Trp
            100                 105                 110         
Glu Ile Phe Met Glu Gln Val Glu Glu Leu Ile Asn Gln Lys Ile Ala
        115                 120                 125             
Glu Tyr Ala Arg Asn Lys Ala Leu Ser Glu Leu Glu Gly Leu Gly Asn
    130                 135                 140                 
Asn Tyr Gln Leu Tyr Leu Thr Ala Leu Glu Glu Trp Lys Glu Asn Pro
145                 150                 155                 160 
Asn Gly Ser Arg Ala Leu Arg Asp Val Arg Asn Arg Phe Glu Ile Leu
                165                 170                 175     
Asp Ser Leu Phe Thr Gln Tyr Met Pro Ser Phe Arg Val Thr Asn Phe
            180                 185                 190         
Glu Val Pro Phe Leu Thr Val Tyr Thr Gln Ala Ala Asn Leu His Leu
        195                 200                 205             
Leu Leu Leu Lys Asp Ala Ser Ile Phe Gly Glu Glu Trp Gly Trp Ser
    210                 215                 220                 
Thr Thr Thr Ile Asn Asn Tyr Tyr Asp Arg Gln Met Lys Leu Thr Ala
225                 230                 235                 240 
Glu Tyr Ser Asp His Cys Val Lys Trp Tyr Glu Thr Gly Leu Ala Lys
                245                 250                 255     
Leu Lys Gly Thr Ser Ala Lys Gln Trp Val Asp Tyr Asn Gln Phe Arg
            260                 265                 270         
Arg Glu Met Thr Leu Thr Val Leu Asp Val Val Ala Leu Phe Pro Asn
        275                 280                 285             
Tyr Asp Thr Arg Thr Tyr Pro Met Glu Thr Lys Ala Gln Leu Thr Arg
    290                 295                 300                 
Glu Val Tyr Thr Asp Pro Leu Gly Ala Val Asn Val Ser Ser Ile Gly
305                 310                 315                 320 
Ser Trp Tyr Asp Lys Ala Pro Ser Phe Gly Val Ile Glu Ser Ser Val
                325                 330                 335     
Ile Arg Pro Pro His Val Phe Asp Tyr Ile Thr Gly Leu Thr Val Tyr
            340                 345                 350         
Thr Gln Ser Arg Ser Ile Ser Ser Ala Arg Tyr Ile Arg His Trp Ala
        355                 360                 365             
Gly His Gln Ile Ser Tyr His Arg Ile Phe Ser Asp Asn Ile Ile Lys
    370                 375                 380                 
Gln Met Tyr Gly Thr Asn Gln Asn Leu His Ser Thr Ser Thr Phe Asp
385                 390                 395                 400 
Phe Thr Asn Tyr Asp Ile Tyr Lys Thr Leu Ser Lys Asp Ala Val Leu
                405                 410                 415     
Leu Asp Ile Val Phe Pro Gly Tyr Thr Tyr Ile Phe Phe Gly Met Pro
            420                 425                 430         
Glu Val Glu Phe Phe Met Val Asn Gln Leu Asn Asn Thr Arg Lys Thr
        435                 440                 445             
Leu Lys Tyr Asn Pro Val Ser Lys Asp Ile Ile Ala Gly Thr Arg Asp
    450                 455                 460                 
Ser Glu Leu Glu Leu Pro Pro Glu Thr Ser Asp Gln Pro Asn Tyr Glu
465                 470                 475                 480 
Ser Tyr Ser His Arg Leu Cys His Ile Thr Ser Ile Pro Ala Thr Gly
                485                 490                 495     
Ser Thr Thr Gly Leu Val Pro Val Phe Ser Trp Thr His Arg Ser Ala
            500                 505                 510         
Asp Leu Ile Asn Ala Val His Ser Asp Lys Ile Thr Gln Ile Pro Val
        515                 520                 525             
Val Lys Val Ser Asp Leu Ala Pro Ser Ile Thr Gly Gly Pro Asn Asn
    530                 535                 540                 
Thr Val Val Ser Gly Pro Gly Phe Thr Gly Gly Gly Ile Ile Lys Val
545                 550                 555                 560 
Ile Arg Asn Gly Val Ile Ile Ser His Met Arg Val Lys Ile Ser Asp
                565                 570                 575     
Ile Asn Lys Glu Tyr Ser Met Arg Ile Arg Tyr Ala Ser Ala Asn Asn
            580                 585                 590         
Thr Glu Phe Tyr Ile Asn Pro Ser Glu Glu Asn Val Lys Ser His Ala
        595                 600                 605             
Gln Lys Thr Met Asn Arg Gly Glu Ala Leu Thr Tyr Asn Lys Phe Asn
    610                 615                 620                 
Tyr Ala Thr Leu Pro Pro Ile Lys Phe Thr Thr Thr Glu Pro Phe Ile
625                 630                 635                 640 
Thr Leu Gly Ala Ile Phe Glu Ala Glu Asp Phe Leu Gly Ile Glu Ala
                645                 650                 655     
Tyr Ile Asp Arg Ile Glu Phe Ile Pro Val Asp Glu Thr Tyr Glu Ala
            660                 665                 670         
Glu Gln Asp Leu Glu Ala Ala Lys Lys Ala Val Asn Ala Leu Phe Thr
        675                 680                 685             
Asn Thr Lys Asp Gly Leu Arg Pro Gly Val Thr Asp Tyr Glu Val Asn
    690                 695                 700                 
Gln Ala Ala Asn Leu Val Glu Cys Leu Ser Asp Asp Leu Tyr Pro Asn
705                 710                 715                 720 
Glu Lys Arg Leu Leu Phe Asp Ala Val Arg Glu Ala Lys Arg Leu Ser
                725                 730                 735     
Glu Ala Arg Asn Leu Leu Gln Asp Pro Asp Phe Gln Glu Ile Asn Gly
            740                 745                 750         
Glu Asn Gly Trp Thr Ala Ser Thr Gly Ile Glu Val Ile Glu Gly Asp
        755                 760                 765             
Ala Leu Phe Lys Gly Arg Tyr Leu Arg Leu Pro Gly Ala Arg Glu Ile
    770                 775                 780                 
Asp Thr Glu Thr Tyr Pro Thr Tyr Leu Tyr Gln Lys Val Glu Glu Gly
785                 790                 795                 800 
Val Leu Lys Pro Tyr Thr Arg Tyr Arg Leu Arg Gly Phe Val Gly Ser
                805                 810                 815     
Ser Gln Gly Leu Glu Ile Phe Thr Ile Arg His Gln Thr Asn Arg Ile
            820                 825                 830         
Val Lys Asn Val Pro Asp Asp Leu Leu Pro Asp Val Ser Pro Val Asn
        835                 840                 845             
Ser Asp Gly Ser Ile Asn Arg Cys Ser Glu Gln Lys Tyr Val Asn Ser
    850                 855                 860                 
Arg Leu Glu Val Glu Asn Arg Ser Gly Glu Ala His Glu Phe Ser Ile
865                 870                 875                 880 
Pro Ile Asp Thr Gly Glu Ile Asp Tyr Asn Glu Asn Ala Gly Ile Trp
                885                 890                 895     
Val Gly Phe Lys Ile Thr Asp Pro Glu Gly Tyr Ala Thr Leu Gly Asn
            900                 905                 910         
Leu Glu Leu Val Glu Glu Gly Pro Leu Ser Gly Asp Ala Leu Glu Arg
        915                 920                 925             
Leu Gln Arg Glu Glu Gln Gln Trp Lys Ile Gln Met Thr Arg Arg Arg
    930                 935                 940                 
Glu Glu Thr Asp Arg Arg Tyr Met Ala Ser Lys Gln Ala Val Asp Arg
945                 950                 955                 960 
Leu Tyr Ala Asp Tyr Gln Asp Gln Gln Leu Asn Pro Asp Val Glu Ile
                965                 970                 975     
Thr Asp Leu Thr Ala Ala Gln Asp Leu Ile Gln Ser Ile Pro Tyr Val
            980                 985                 990         
Tyr Asn Glu Met Phe Pro Glu Ile Pro Gly Met Asn Tyr Thr Lys Phe
        995                 1000                1005            
Thr Glu Leu Thr Asp Arg Leu Gln Gln Ala Trp Ser Leu Tyr Asp Gln
    1010                1015                1020                
Arg Asn Ala Ile Pro Asn Gly Asp Phe Arg Asn Gly Leu Ser Asn Trp
1025                1030                1035               1040 
Asn Ala Thr Pro Gly Val Glu Val Gln Gln Ile Asn His Thr Ser Val
                1045                1050                1055    
Leu Val Ile Pro Asn Trp Asp Glu Gln Val Ser Gln Gln Phe Thr Val
            1060                1065                1070        
Gln Pro Asn Gln Arg Tyr Val Leu Arg Val Thr Ala Arg Lys Glu Gly
        1075                1080                1085            
Val Gly Asn Gly Tyr Val Ser Ile Arg Asp Gly Gly Asn Gln Thr Glu
    1090                1095                1100                
Thr Leu Thr Phe Ser Ala Ser Asp Tyr Asp Thr Asn Gly Met Tyr Asn
1105                1110                1115               1120 
Thr Gln Val Ser Asn Thr Asn Gly Tyr Asn Thr Asn Asn Ala Tyr Asn
                1125                1130                1135    
Thr Gln Ala Ser Ser Thr Asn Gly Tyr Asn Ala Asn Asn Met Tyr Asn
            1140                1145                1150        
Thr Gln Ala Ser Asn Thr Asn Gly Tyr Asn Thr Asn Ser Val Tyr Asn
        1155                1160                1165            
Asp Gln Thr Gly Tyr Ile Thr Lys Thr Val Thr Phe Ile Pro Tyr Thr
    1170                1175                1180                
Asp Gln Met Trp Ile Glu Met Ser Glu Thr Glu Gly Thr Phe Tyr Ile
1185                1190                1195               1200 
Glu Ser Val Glu Leu Ile Val Asp Val Glu
                1205                1210


<210> 64
<211> 1138
<212> PRT
<213> Bacillus thuringiensis

<400> 64
Met Asn Leu Asn Asn Leu Asp Gly Tyr Glu Asp Ser Asn Arg Thr Leu
 1               5                  10                  15      
Asn Asn Ser Leu Asn Tyr Pro Thr Gln Lys Ala Leu Ser Pro Ser Leu
            20                  25                  30          
Lys Asn Met Asn Tyr Gln Asp Phe Leu Ser Ile Thr Glu Arg Glu Gln
        35                  40                  45              
Pro Glu Ala Leu Ala Ser Gly Asn Thr Ala Ile Asn Thr Val Val Ser
    50                  55                  60                  
Val Thr Gly Ala Thr Leu Ser Ala Leu Gly Val Pro Gly Ala Ser Phe
65                  70                  75                  80  
Ile Thr Asn Phe Tyr Leu Lys Ile Ala Gly Leu Leu Trp Pro Glu Asn
                85                  90                  95      
Gly Lys Ile Trp Asp Glu Phe Met Thr Glu Val Glu Ala Leu Ile Asp
            100                 105                 110         
Gln Lys Ile Glu Glu Tyr Val Arg Asn Lys Ala Ile Ala Glu Leu Asp
        115                 120                 125             
Gly Leu Gly Ser Ala Leu Asp Lys Tyr Gln Lys Ala Leu Ala Asp Trp
    130                 135                 140                 
Leu Gly Lys Gln Asp Asp Pro Glu Ala Ile Leu Ser Val Ala Thr Glu
145                 150                 155                 160 
Phe Arg Ile Ile Asp Ser Leu Phe Glu Phe Ser Met Pro Ser Phe Lys
                165                 170                 175     
Val Thr Gly Tyr Glu Ile Pro Leu Leu Thr Val Tyr Ala Gln Ala Ala
            180                 185                 190         
Asn Leu His Leu Ala Leu Leu Arg Asp Ser Thr Leu Tyr Gly Asp Lys
        195                 200                 205             
Trp Gly Phe Thr Gln Asn Asn Ile Glu Glu Asn Tyr Asn Arg Gln Lys
    210                 215                 220                 
Lys Arg Ile Ser Glu Tyr Ser Asp His Cys Thr Lys Trp Tyr Asn Ser
225                 230                 235                 240 
Gly Leu Ser Arg Leu Asn Gly Ser Thr Tyr Glu Gln Trp Ile Asn Tyr
                245                 250                 255     
Asn Arg Phe Arg Arg Glu Met Ile Leu Met Ala Leu Asp Leu Val Ala
            260                 265                 270         
Val Phe Pro Phe His Asp Pro Arg Arg Tyr Ser Met Glu Thr Ser Thr
        275                 280                 285             
Gln Leu Thr Arg Glu Val Tyr Thr Asp Pro Val Ser Leu Ser Ile Ser
    290                 295                 300                 
Asn Pro Asp Ile Gly Pro Ser Phe Ser Gln Met Glu Asn Thr Ala Ile
305                 310                 315                 320 
Arg Thr Pro His Leu Val Asp Tyr Leu Asp Glu Leu Tyr Ile Tyr Thr
                325                 330                 335     
Ser Lys Tyr Lys Ala Phe Ser His Glu Ile Gln Pro Asp Leu Phe Tyr
            340                 345                 350         
Trp Ser Ala His Lys Val Ser Phe Lys Lys Ser Glu Gln Ser Asn Leu
        355                 360                 365             
Tyr Thr Thr Gly Ile Tyr Gly Lys Thr Ser Gly Tyr Ile Ser Ser Gly
    370                 375                 380                 
Ala Tyr Ser Phe His Gly Asn Asp Ile Tyr Arg Thr Leu Ala Ala Pro
385                 390                 395                 400 
Ser Val Val Val Tyr Pro Tyr Thr Gln Asn Tyr Gly Val Glu Gln Val
                405                 410                 415     
Glu Phe Tyr Gly Val Lys Gly His Val His Tyr Arg Gly Asp Asn Lys
            420                 425                 430         
Tyr Asp Leu Thr Tyr Asp Ser Ile Asp Gln Leu Pro Pro Asp Gly Glu
        435                 440                 445             
Pro Ile His Glu Lys Tyr Thr His Arg Leu Cys His Ala Thr Ala Ile
    450                 455                 460                 
Phe Lys Ser Thr Pro Asp Tyr Asp Asn Ala Thr Ile Pro Ile Phe Ser
465                 470                 475                 480 
Trp Thr His Arg Ser Ala Glu Tyr Tyr Asn Arg Ile Tyr Pro Asn Lys
                485                 490                 495     
Ile Thr Lys Ile Pro Ala Val Lys Met Tyr Lys Leu Asp Asp Pro Ser
            500                 505                 510         
Thr Val Val Lys Gly Pro Gly Phe Thr Gly Gly Asp Leu Val Lys Arg
        515                 520                 525             
Gly Ser Thr Gly Tyr Ile Gly Asp Ile Lys Ala Thr Val Asn Ser Pro
    530                 535                 540                 
Leu Ser Gln Lys Tyr Arg Val Arg Val Arg Tyr Ala Thr Asn Val Ser
545                 550                 555                 560 
Gly Gln Phe Asn Val Tyr Ile Asn Asp Lys Ile Thr Leu Gln Thr Lys
                565                 570                 575     
Phe Gln Asn Thr Val Glu Thr Ile Gly Glu Gly Lys Asp Leu Thr Tyr
            580                 585                 590         
Gly Ser Phe Gly Tyr Ile Glu Tyr Ser Thr Thr Ile Gln Phe Pro Asp
        595                 600                 605             
Glu His Pro Lys Ile Thr Leu His Leu Ser Asp Leu Ser Asn Asn Ser
    610                 615                 620                 
Ser Phe Tyr Val Asp Ser Ile Glu Phe Ile Pro Val Asp Val Asn Tyr
625                 630                 635                 640 
Ala Glu Lys Glu Lys Leu Glu Lys Ala Gln Lys Ala Val Asn Thr Leu
                645                 650                 655     
Phe Thr Glu Gly Arg Asn Ala Leu Gln Lys Asp Val Thr Asp Tyr Lys
            660                 665                 670         
Val Asp Gln Val Ser Ile Leu Val Asp Cys Ile Ser Gly Asp Leu Tyr
        675                 680                 685             
Pro Asn Glu Lys Arg Glu Leu Gln Asn Leu Val Lys Tyr Ala Lys Arg
    690                 695                 700                 
Leu Ser Tyr Ser Arg Asn Leu Leu Leu Asp Pro Thr Phe Asp Ser Ile
705                 710                 715                 720 
Asn Ser Ser Glu Glu Asn Gly Trp Tyr Gly Ser Asn Gly Ile Val Ile
                725                 730                 735     
Gly Asn Gly Asp Phe Val Phe Lys Gly Asn Tyr Leu Ile Phe Ser Gly
            740                 745                 750         
Thr Asn Asp Thr Gln Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu
        755                 760                 765             
Ser Lys Leu Lys Glu Tyr Thr Arg Tyr Lys Leu Lys Gly Phe Ile Glu
    770                 775                 780                 
Ser Ser Gln Asp Leu Glu Ala Tyr Val Ile Arg Tyr Asp Ala Lys His
785                 790                 795                 800 
Arg Thr Leu Asp Val Ser Asp Asn Leu Leu Pro Asp Ile Leu Pro Glu
                805                 810                 815     
Asn Thr Cys Gly Glu Pro Asn Arg Cys Ala Ala Gln Gln Tyr Leu Asp
            820                 825                 830         
Glu Asn Pro Ser Pro Glu Cys Ser Ser Met Gln Asp Gly Ile Leu Ser
        835                 840                 845             
Asp Ser His Ser Phe Ser Leu Asn Ile Asp Thr Gly Ser Ile Asn His
    850                 855                 860                 
Asn Glu Asn Leu Gly Ile Trp Val Leu Phe Lys Ile Ser Thr Leu Glu
865                 870                 875                 880 
Gly Tyr Ala Lys Phe Gly Asn Leu Glu Val Ile Glu Asp Gly Pro Val
                885                 890                 895     
Ile Gly Glu Ala Leu Ala Arg Val Lys Arg Gln Glu Thr Lys Trp Arg
            900                 905                 910         
Asn Lys Leu Ala Gln Leu Thr Thr Glu Thr Gln Ala Ile Tyr Thr Arg
        915                 920                 925             
Ala Lys Gln Ala Leu Asp Asn Leu Phe Ala Asn Ala Gln Asp Ser His
    930                 935                 940                 
Leu Lys Arg Asp Val Thr Phe Ala Glu Ile Ala Ala Ala Arg Lys Ile
945                 950                 955                 960 
Val Gln Ser Ile Arg Glu Ala Tyr Met Ser Trp Leu Ser Val Val Pro
                965                 970                 975     
Gly Val Asn His Pro Ile Phe Thr Glu Leu Ser Gly Arg Val Gln Arg
            980                 985                 990         
Ala Phe Gln Leu Tyr Asp Val Arg Asn Val Val Arg Asn Gly Arg Phe
        995                 1000                1005            
Leu Asn Gly Leu Ser Asp Trp Ile Val Thr Ser Asp Val Lys Val Gln
    1010                1015                1020                
Glu Glu Asn Gly Asn Asn Val Leu Val Leu Asn Asn Trp Asp Ala Gln
1025                1030                1035               1040 
Val Leu Gln Asn Val Lys Leu Tyr Gln Asp Arg Gly Tyr Ile Leu His
                1045                1050                1055    
Val Thr Ala Arg Lys Ile Gly Ile Gly Glu Gly Tyr Ile Thr Ile Thr
            1060                1065                1070        
Asp Glu Glu Gly His Thr Asp Gln Leu Arg Phe Thr Ala Cys Glu Glu
        1075                1080                1085            
Ile Asp Ala Ser Asn Ala Phe Ile Ser Gly Tyr Ile Thr Lys Glu Leu
    1090                1095                1100                
Glu Phe Phe Pro Asp Thr Glu Lys Val His Ile Glu Ile Gly Glu Thr
1105                1110                1115               1120 
Glu Gly Ile Phe Leu Val Glu Ser Ile Glu Leu Phe Leu Met Glu Glu
                1125                1130                1135    
Leu Cys
        

