                         SEQUENCE LISTING

<110>  Molecular Innovations
 
<120>  METHODS FOR SCREENING CANDIDATE AGENTS FOR MODULATING PRORENIN 
       AND RENIN, ASSAYS FOR DETECTING PRORENIN, AND ANTIBODIES USED 
       THEREIN

<130>  03149.000017.PC

<150>  61/149,834
<151>  2009-02-04

<150>  61/150,462
<151>  2009-02-06

<150>  61/152,285
<151>  2009-02-13

<150>  61/159,233
<151>  2009-03-11

<150>  61/160,011
<151>  2009-03-13

<150>  61/234,424
<151>  2009-08-17

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu Pro Thr Asp Thr Thr Thr Phe Lys Arg Ile Phe Leu Lys Arg Met 
1               5                   10                  15      


Pro Ser Ile Arg Glu Ser Leu Lys Glu Arg Gly Val Asp Met Ala Arg 
            20                  25                  30          


Leu Gly Pro Glu Trp Ser Gln Pro Met Lys Arg Leu Thr Leu Gly Asn 
        35                  40                  45              


Thr Thr Ser Ser Val Ile Leu Thr Asn Tyr Met Asp Thr Gln Tyr Tyr 
    50                  55                  60                  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Thr Phe Lys Val Val Phe 
65                  70                  75                  80  


Asp Thr Gly Ser Ser Asn Val Trp Val Pro Ser Ser Lys Cys Ser Arg 
                85                  90                  95      


Leu Tyr Thr Ala Cys Val Tyr His Lys Leu Phe Asp Ala Ser Asp Ser 
            100                 105                 110         


Ser Ser Tyr Lys His Asn Gly Thr Glu Leu Thr Leu Arg Tyr Ser Thr 
        115                 120                 125             


Gly Thr Val Ser Gly Phe Leu Ser Gln Asp Ile Ile Thr Val Gly Gly 
    130                 135                 140                 


Ile Thr Val Thr Gln Met Phe Gly Glu Val Thr Glu Met Pro Ala Leu 
145                 150                 155                 160 


Pro Phe Met Leu Ala Glu Phe Asp Gly Val Val Gly Met Gly Phe Ile 
                165                 170                 175     


Glu Gln Ala Ile Gly Arg Val Thr Pro Ile Phe Asp Asn Ile Ile Ser 
            180                 185                 190         


Gln Gly Val Leu Lys Glu Asp Val Phe Ser Phe Tyr Tyr Asn Arg Asp 
        195                 200                 205             


Ser Glu Asn Ser Gln Ser Leu Gly Gly Gln Ile Val Leu Gly Gly Ser 
    210                 215                 220                 


Asp Pro Gln His Tyr Glu Gly Asn Phe His Tyr Ile Asn Leu Ile Lys 
225                 230                 235                 240 


Thr Gly Val Trp Gln Ile Gln Met Lys Gly Val Ser Val Gly Ser Ser 
                245                 250                 255     


Thr Leu Leu Cys Glu Asp Gly Cys Leu Ala Leu Val Asp Thr Gly Ala 
            260                 265                 270         


Ser Tyr Ile Ser Gly Ser Thr Ser Ser Ile Glu Lys Leu Met Glu Ala 
        275                 280                 285             


Leu Gly Ala Lys Lys Arg Leu Phe Asp Tyr Val Val Lys Cys Asn Glu 
    290                 295                 300                 


Gly Pro Thr Leu Pro Asp Ile Ser Phe His Leu Gly Gly Lys Glu Tyr 
305                 310                 315                 320 


Thr Leu Thr Ser Ala Asp Tyr Val Phe Gln Glu Ser Tyr Ser Ser Lys 
                325                 330                 335     


Lys Leu Cys Thr Leu Ala Ile His Ala Met Asp Ile Pro Pro Pro Thr 
            340                 345                 350         


Gly Pro Thr Trp Ala Leu Gly Ala Thr Phe Ile Arg Lys Phe Tyr Thr 
        355                 360                 365             


Glu Phe Asp Arg Arg Asn Asn Arg Ile Gly Phe Ala Leu Ala Arg 
    370                 375                 380             


<210>  2
<211>  1152
<212>  DNA
<213>  Homo sapiens

<400>  2
ctcccgacag acaccaccac ctttaaacgg atcttcctca agagaatgcc ctcaatccga       60

gaaagcctga aggaacgagg tgtggacatg gccaggcttg gtcccgagtg gagccaaccc      120

atgaagaggc tgacacttgg caacaccacc tcctccgtga tcctcaccaa ctacatggac      180

acccagtact atggcgagat tggcatcggc accccacccc agaccttcaa agtcgtcttt      240

gacactggtt cgtccaatgt ttgggtgccc tcctccaagt gcagccgtct ctacactgcc      300

tgtgtgtatc acaagctctt cgatgcttcg gattcctcca gctacaagca caatggaaca      360

gaactcaccc tccgctattc aacagggaca gtcagtggct ttctcagcca ggacatcatc      420

accgtgggtg gaatcacggt gacacagatg tttggagagg tcacggagat gcccgcctta      480

cccttcatgc tggccgagtt tgatggggtt gtgggcatgg gcttcattga acaggccatt      540

ggcagggtca cccctatctt cgacaacatc atctcccaag gggtgctaaa agaggacgtc      600

ttctctttct actacaacag agattccgag aattcccaat cgctgggagg acagattgtg      660

ctgggaggca gcgaccccca gcattacgaa gggaatttcc actatatcaa cctcatcaag      720

actggtgtct ggcagattca aatgaagggg gtgtctgtgg ggtcatccac cttgctctgt      780

gaagacggct gcctggcatt ggtagacacc ggtgcatcct acatctcagg ttctaccagc      840

tccatagaga agctcatgga ggccttggga gccaagaaga ggctgtttga ttatgtcgtg      900

aagtgtaacg agggccctac actccccgac atctctttcc acctgggagg caaagaatac      960

acgctcacca gcgcggacta tgtatttcag gaatcctaca gtagtaaaaa gctgtgcaca     1020

ctggccatcc acgccatgga tatcccgcca cccactggac ccacctgggc cctgggggcc     1080

accttcatcc gaaagttcta cacagagttt gatcggcgta acaaccgcat tggcttcgcc     1140

ttggcccgct ga                                                         1152


<210>  3
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Arg Leu Gly Pro Glu Trp Ser 
1               5               


<210>  4
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Arg Val Tyr Ile His Pro Phe His Leu Val Ile His Thr 
1               5                   10                  


<210>  5
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Lys His Pro Phe His Leu Val Ile His 
1               5                   10  


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Arg Leu Gly Pro Glu Trp 
1               5           


<210>  7
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys His Pro Phe His Leu Val Ile His Ala Arg Leu Gly Pro Glu Trp 
1               5                   10                  15      


Ser 
    


<210>  8
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys His Pro Phe His Leu Val Ile His Ala Arg Leu Gly Pro Glu Trp 
1               5                   10                  15      


<210>  9
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Pro Thr Asp Thr Thr Thr Phe Lys Arg Ile Phe Leu Lys Arg Met 
1               5                   10                  15      


Pro Ser Ile Arg Glu Ser Leu Lys Glu Arg Gly Val Asp Met Ala Arg 
            20                  25                  30          


Leu Gly Pro Glu Trp Ser Gln Pro Met Lys Arg 
        35                  40              


<210>  10
<211>  16
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotin

<400>  10

Xaa Leu Pro Thr Asp Thr Thr Thr Phe Lys Arg Ile Phe Leu Lys Arg 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotin

<400>  11

Xaa Thr Asp Thr Thr Thr Phe Lys Arg Ile Phe Leu Lys Arg Met Pro 
1               5                   10                  15      


<210>  12
<211>  18
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotin

<400>  12

Xaa Lys Arg Met Pro Ser Ile Arg Glu Ser Leu Lys Glu Arg Gly Val 
1               5                   10                  15      


Asp Met 
        


<210>  13
<211>  18
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotin

<400>  13

Xaa Gly Val Asp Met Ala Arg Leu Gly Pro Glu Trp Ser Gln Pro Met 
1               5                   10                  15      


Lys Arg 
        


<210>  14
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Arg Leu Gly Pro Glu Trp Ser Gln Pro Met Lys Arg 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotin

<400>  15

Xaa Ala Arg Leu Gly Pro Glu Trp Ser Gln Pro Met Lys Arg 
1               5                   10                  


<210>  16
<211>  13
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotin

<400>  16

Xaa Arg Leu Gly Pro Glu Trp Ser Gln Pro Met Lys Arg 
1               5                   10              


<210>  17
<211>  12
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotin

<400>  17

Xaa Leu Gly Pro Glu Trp Ser Gln Pro Met Lys Arg 
1               5                   10          


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Arg Leu Gly Pro Glu Trp Ser Gln 
1               5                   


<210>  19
<211>  10
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotin

<400>  19

Xaa Ala Arg Leu Gly Pro Glu Trp Ser Gln 
1               5                   10  


<210>  20
<211>  9
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotin

<400>  20

Xaa Ala Arg Leu Gly Pro Glu Trp Ser 
1               5                   


<210>  21
<211>  8
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotin

<400>  21

Xaa Ala Arg Leu Gly Pro Glu Trp 
1               5               


<210>  22
<211>  18
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotin

<400>  22

Xaa Lys His Pro Phe His Leu Val Ile His Ala Arg Leu Gly Pro Glu 
1               5                   10                  15      


Trp Ser 
        


