                         SEQUENCE LISTING

<110>  RXi Pharmaceuticals Corporation
       Woolf, Tod
       Kamens, Joanne
       Salomon, William
       Khvorova, Anastasia
 
<120>  RNA DUPLEXES WITH SINGLE STRANDED PHOSHOROTHIOATE NUCLEOTIDE 
       REGIONS FOR ADDITIONAL FUNCTIONALITY

<130>  R0659.70001

<140>  not yet assigned
<141>  2010-02-04

<150>  US 61/163,306
<151>  2009-03-25

<150>  US 61/150,582
<151>  2009-02-06

<150>  US 61/149,968
<151>  2009-02-04

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(25)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (25)..(37)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  ribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(37)
<223>  deoxyribonucleotide

<400>  1
cucuucggaa agacuguucc aaaaaccttc cctgaag                                37


<210>  2
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  2
uuuuuggaac agucuuuccg aagag                                             25


<210>  3
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(25)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (22)..(45)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  ribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(45)
<223>  deoxyribonucleotide

<400>  3
cucuucggaa agacuguucc aaaaaccttc cctgaaggtt cctcc                       45


<210>  4
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  4
uuuuuggaac agucuuuccg aagag                                             25


<210>  5
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(25)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (25)..(37)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  ribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(37)
<223>  deoxyribonucleotide

<400>  5
gcacucugau ugacaaauac gauuuccttc cctgaag                                37


<210>  6
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  6
aaaucguauu ugucaaucag agugc                                             25


<210>  7
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(25)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (25)..(45)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  ribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(45)
<223>  deoxyribonucleotide

<400>  7
gcacucugau ugacaaauac gauuuccttc cctgaaggtt cctcc                       45


<210>  8
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  8
aaaucguauu ugucaaucag agugc                                             25


<210>  9
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<400>  9
cucuucggaa agacuguucc aaaaa                                             25


<210>  10
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  10
uuuuuggaac agucuuuccg aagag                                             25


<210>  11
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(37)
<223>  ribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(23)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (27)..(37)
<223>  2'-O-methyl

<400>  11
ccttccctga aggcacucug auugacaaau acgauuu                                37


<210>  12
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  12
aaaucguauu ugucaaucag agugc                                             25


<210>  13
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(37)
<223>  ribonucleotide


<400>  13
ccttccctga aggcacucug auugacaaau acgauuu                                37


<210>  14
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  14
aaaucguauu ugucaaucag agugc                                             25


<210>  15
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(37)
<223>  ribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(25)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (29)..(37)
<223>  2'-O-methyl

<400>  15
ccttccctga agcucuucgg aaagacuguu ccaaaaa                                37


<210>  16
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  16
uuuuuggaac agucuuuccg aagag                                             25


<210>  17
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(37)
<223>  ribonucleotide


<400>  17
ccttccctga agcucuucgg aaagacuguu ccaaaaa                                37


<210>  18
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  18
uuuuuggaac agucuuuccg aagag                                             25


<210>  19
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  3'-cholesterol

<400>  19
cuguggaagu cua                                                          13


<210>  20
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (13)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-o-methyl

<400>  20
uagacuucca cagaacucu                                                    19


<210>  21
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  3'-cholesterol

<400>  21
cuguggaagu cua                                                          13


<210>  22
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<400>  22
uagacuucca cagaacucu                                                    19


<210>  23
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  3'-cholesterol

<400>  23
cuguggaagu cua                                                          13


<210>  24
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-fluoro

<400>  24
uagacuucca cagaacucu                                                    19


<210>  25
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  3'-cholesterol

<400>  25
cuguggaagu cua                                                          13


<210>  26
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  phosphorothioate linkage

<400>  26
uagacuucca cagaacucu                                                    19


<210>  27
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<400>  27
cuguggaagu cua                                                          13


<210>  28
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-fluoro

<400>  28
uagacuucca cagaacucu                                                    19


<210>  29
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-Cy3

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(25)
<223>  2'-O-methyl

<400>  29
cucuucggaa agacuguucc aaaaa                                             25


<210>  30
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  30
uuuuuggaac agucuuuccg aagag                                             25


<210>  31
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  3'-cholesterol

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  phosphorothioate linkage

<400>  31
cuguggaagu cua                                                          13


<210>  32
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-fluoro

<400>  32
uagacuucca cagaacucu                                                    19


