                         SEQUENCE LISTING

<110>  Ecole Polytechnique Fdrale de Lausanne (EPFL)
 
<120>  USE OF IGF-1 AND NT-3 IN THE TREATMENT OF X-LINKED 
       ADRENOLEUKODYSTROPHY

<130>  P1207PC00

<150>  US 61/149,829
<151>  2009-02-04

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  2
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  2

Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Asp Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Arg Lys Ile Gly Arg Thr 
        115                 


<210>  3
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
    130                 135                 140                 


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
145                 150             


<210>  4
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Thr Phe Ala Thr Ile Leu Gln Val Asn Lys Val Met Ser Ile 
1               5                   10                  15      


Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile Gln Gly Asn 
            20                  25                  30          


Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn Ser Leu Ile 
        35                  40                  45              


Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu Ser Lys Gln 
    50                  55                  60                  


Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro Lys Ala Glu 
65                  70                  75                  80  


Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser Ala Phe Gln 
                85                  90                  95      


Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln Arg Arg Tyr 
            100                 105                 110         


Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu Glu Pro Pro 
        115                 120                 125             


Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val Val Ala Asn 
    130                 135                 140                 


Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser His Arg Gly 
145                 150                 155                 160 


Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr Asp Lys Ser 
                165                 170                 175     


Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu Gly Glu Ile 
            180                 185                 190         


Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu Thr Arg Cys 
        195                 200                 205             


Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile Asp Asp Lys 
    210                 215                 220                 


His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val Arg Ala Leu 
225                 230                 235                 240 


Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile Arg Ile Asp 
                245                 250                 255     


Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg Thr 
            260                 265                 270 


<210>  5
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  5
atgggaaaaa tcagcagtct tccaacccaa ttatttaagt gctgcttttg tgatttcttg       60

aaggtgaaga tgcacaccat gtcctcctcg catctcttct acctggcgct gtgcctgctc      120

accttcacca gctctgccac ggctggaccg gagacgctct gcggggctga gctggtggat      180

gctcttcagt tcgtgtgtgg agacaggggc ttttatttca acaagcccac agggtatggc      240

tccagcagtc ggagggcgcc tcagacaggc atcgtggatg agtgctgctt ccggagctgt      300

gatctaagga ggctggagat gtattgcgca cccctcaagc ctgccaagtc agctcgctct      360

gtccgtgccc agcgccacac cgacatgccc aagacccaga aggaagtaca tttgaagaac      420

gcaagtagag ggagtgcagg aaacaagaac tacaggatgt ag                         462


<210>  6
<211>  813
<212>  DNA
<213>  Homo sapiens

<400>  6
atggttactt ttgccacgat cttacaggtg aacaaggtga tgtccatctt gttttatgtg       60

atatttctcg cttatctccg tggcatccaa ggtaacaaca tggatcaaag gagtttgcca      120

gaagactcgc tcaattccct cattattaag ctgatccagg cagatatttt gaaaaacaag      180

ctctccaagc agatggtgga cgttaaggaa aattaccaga gcaccctgcc caaagctgag      240

gctccccgag agccggagcg gggagggccc gccaagtcag cattccagcc ggtgattgca      300

atggacaccg aactgctgcg acaacagaga cgctacaact caccgcgggt cctgctgagc      360

gacagcaccc ccttggagcc cccgcccttg tatctcatgg aggattacgt gggcagcccc      420

gtggtggcga acagaacatc acggcggaaa cggtacgcgg agcataagag tcaccgaggg      480

gagtactcgg tatgtgacag tgagagtctg tgggtgaccg acaagtcatc ggccatcgac      540

attcggggac accaggtcac ggtgctgggg gagatcaaaa cgggcaactc tcccgtcaaa      600

caatattttt atgaaacgcg atgtaaggaa gccaggccgg tcaaaaacgg ttgcaggggt      660

attgatgata aacactggaa ctctcagtgc aaaacatccc aaacctacgt ccgagcactg      720

acttcagaga acaataaact cgtgggctgg cggtggatac ggatagacac gtcctgtgtg      780

tgtgccttgt cgagaaaaat cggaagaaca tga                                   813


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR sense primer for amplification of a fragment of the 
       beta-globin intron

<400>  7
cgtgccaaga gtgacgtaag                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR anti-sense primer for amplification of a fragment of the 
       beta-globin intron

<400>  8
tggtgcaaag aggcatgata                                                   20


<210>  9
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR sense primer for amplification of a fragment of the albumin 
       gene

<400>  9
tgaaacatac gttcccaaag agttt                                             25


<210>  10
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR anti-sense primer for amplification of a fragment of the 
       albumin gene

<400>  10
ctctccttct cagaaagtgt gcatat                                            26


