                         SEQUENCE LISTING

<110>  University of Texas M.D. Anderson Cancer Center
       Ajani, Jaffer A.
       Izzo, Julie
       Wang, Xuemei
       Berry, Donald
 
<120>  BIOMARKER SIGNATURE TO PREDICT CANCER TREATMENT RESPONSE

<130>  UTSC:1018WO0

<140>  TBA
<141>  2010-02-02

<150>  61149204
<151>  2009-02-02

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  462
<212>  PRT
<213>  Human

<400>  1

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Gly Pro Gly Arg Gly Phe Gly Lys 
            20                  25                  30          


Arg Arg His Pro Lys Lys Leu Thr Pro Leu Ala Tyr Lys Gln Phe Ile 
        35                  40                  45              


Pro Asn Val Ala Glu Lys Thr Leu Gly Ala Ser Gly Arg Tyr Glu Gly 
    50                  55                  60                  


Lys Ile Ser Arg Asn Ser Glu Arg Phe Lys Glu Leu Thr Pro Asn Tyr 
65                  70                  75                  80  


Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Thr Gly Ala Asp Arg 
                85                  90                  95      


Leu Met Thr Gln Arg Cys Lys Asp Lys Leu Asn Ala Leu Ala Ile Ser 
            100                 105                 110         


Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg Val Thr Glu Gly Trp 
        115                 120                 125             


Asp Glu Asp Gly His His Ser Glu Glu Ser Leu His Tyr Glu Gly Arg 
    130                 135                 140                 


Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg Ser Lys Tyr Gly Met 
145                 150                 155                 160 


Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr Glu 
                165                 170                 175     


Ser Lys Ala His Ile His Cys Ser Val Lys Ala Glu Asn Ser Val Ala 
            180                 185                 190         


Ala Lys Ser Gly Gly Cys Phe Pro Gly Ser Ala Thr Val His Leu Glu 
        195                 200                 205             


Gln Gly Gly Thr Lys Leu Val Lys Asp Leu Ser Pro Gly Asp Arg Val 
    210                 215                 220                 


Leu Ala Ala Asp Asp Gln Gly Arg Leu Leu Tyr Ser Asp Phe Leu Thr 
225                 230                 235                 240 


Phe Leu Asp Arg Asp Asp Gly Ala Lys Lys Val Phe Tyr Val Ile Glu 
                245                 250                 255     


Thr Arg Glu Pro Arg Glu Arg Leu Leu Leu Thr Ala Ala His Leu Leu 
            260                 265                 270         


Phe Val Ala Pro His Asn Asp Ser Ala Thr Gly Glu Pro Glu Ala Ser 
        275                 280                 285             


Ser Gly Ser Gly Pro Pro Ser Gly Gly Ala Leu Gly Pro Arg Ala Leu 
    290                 295                 300                 


Phe Ala Ser Arg Val Arg Pro Gly Gln Arg Val Tyr Val Val Ala Glu 
305                 310                 315                 320 


Arg Asp Gly Asp Arg Arg Leu Leu Pro Ala Ala Val His Ser Val Thr 
                325                 330                 335     


Leu Ser Glu Glu Ala Ala Gly Ala Tyr Ala Pro Leu Thr Ala Gln Gly 
            340                 345                 350         


Thr Ile Leu Ile Asn Arg Val Leu Ala Ser Cys Tyr Ala Val Ile Glu 
        355                 360                 365             


Glu His Ser Trp Ala His Arg Ala Phe Ala Pro Phe Arg Leu Ala His 
    370                 375                 380                 


Ala Leu Leu Ala Ala Leu Ala Pro Ala Arg Thr Asp Arg Gly Gly Asp 
385                 390                 395                 400 


Ser Gly Gly Gly Asp Arg Gly Gly Gly Gly Gly Arg Val Ala Leu Thr 
                405                 410                 415     


Ala Pro Gly Ala Ala Asp Ala Pro Gly Ala Gly Ala Thr Ala Gly Ile 
            420                 425                 430         


His Trp Tyr Ser Gln Leu Leu Tyr Gln Ile Gly Thr Trp Leu Leu Asp 
        435                 440                 445             


Ser Glu Ala Leu His Pro Leu Gly Met Ala Val Lys Ser Ser 
    450                 455                 460         


<210>  2
<211>  1576
<212>  DNA
<213>  Human

<400>  2
gcgaggcagc cagcgaggga gagagcgagc gggcgagccg gagcgaggaa gggaaagcgc       60

aagagagagc gcacacgcac acacccgccg cgcgcactcg cgcacggacc cgcacgggga      120

cagctcggaa gtcatcagtt ccatgggcga gatgctgctg ctggcgagat gtctgctgct      180

agtcctcgtc tcctcgctgc tggtatgctc gggactggcg tgcggaccgg gcagggggtt      240

cgggaagagg aggcacccca aaaagctgac ccctttagcc tacaagcagt ttatccccaa      300

tgtggccgag aagaccctag gcgccagcgg aaggtatgaa gggaagatct ccagaaactc      360

cgagcgattt aaggaactca cccccaatta caaccccgac atcatattta aggatgaaga      420

aaacaccgga gcggacaggc tgatgactca gaggtgtaag gacaagttga acgctttggc      480

catctcggtg atgaaccagt ggccaggagt gaaactgcgg gtgaccgagg gctgggacga      540

agatggccac cactcagagg agtctctgca ctacgagggc cgcgcagtgg acatcaccac      600

gtctgaccgc gaccgcagca agtacggcat gctggcccgc ctggcggtgg aggccggctt      660

cgactgggtg tactacgagt ccaaggcaca tatccactgc tcggtgaaag cagagaactc      720

ggtggcggcc aaatcgggag gctgcttccc gggctcggcc acggtgcacc tggagcaggg      780

cggcaccaag ctggtgaagg acctgagccc cggggaccgc gtgctggcgg cggacgacca      840

gggccggctg ctctacagcg acttcctcac tttcctggac cgcgacgacg gcgccaagaa      900

ggtcttctac gtgatcgaga cgcgggagcc gcgcgagcgc ctgctgctca ccgccgcgca      960

cctgctcttt gtggcgccgc acaacgactc ggccaccggg gagcccgagg cgtcctcggg     1020

ctcggggccg ccttccgggg gcgcactggg gcctcgggcg ctgttcgcca gccgcgtgcg     1080

cccgggccag cgcgtgtacg tggtggccga gcgtgacggg gaccgccggc tcctgcccgc     1140

cgctgtgcac agcgtgaccc taagcgagga ggccgcgggc gcctacgcgc cgctcacggc     1200

ccagggcacc attctcatca accgggtgct ggcctcgtgc tacgcggtca tcgaggagca     1260

cagctgggcg caccgggcct tcgcgccctt ccgcctggcg cacgcgctcc tggctgcact     1320

ggcgcccgcg cgcacggacc gcggcgggga cagcggcggc ggggaccgcg ggggcggcgg     1380

cggcagagta gccctaaccg ctccaggtgc tgccgacgct ccgggtgcgg gggccaccgc     1440

gggcatccac tggtactcgc agctgctcta ccaaataggc acctggctcc tggacagcga     1500

ggccctgcac ccgctgggca tggcggtcaa gtccagctga agccgggggg ccgggggagg     1560

ggcgcgggag ggggcg                                                     1576


<210>  3
<211>  1106
<212>  PRT
<213>  Human

<400>  3

Met Phe Asn Ser Met Thr Pro Pro Pro Ile Ser Ser Tyr Gly Glu Pro 
1               5                   10                  15      


Cys Cys Leu Arg Pro Leu Pro Ser Gln Gly Ala Pro Ser Val Gly Thr 
            20                  25                  30          


Glu Gly Leu Ser Gly Pro Pro Phe Cys His Gln Ala Asn Leu Met Ser 
        35                  40                  45              


Gly Pro His Ser Tyr Gly Pro Ala Arg Glu Thr Asn Ser Cys Thr Glu 
    50                  55                  60                  


Gly Pro Leu Phe Ser Ser Pro Arg Ser Ala Val Lys Leu Thr Lys Lys 
65                  70                  75                  80  


Arg Ala Leu Ser Ile Ser Pro Leu Ser Asp Ala Ser Leu Asp Leu Gln 
                85                  90                  95      


Thr Val Ile Arg Thr Ser Pro Ser Ser Leu Val Ala Phe Ile Asn Ser 
            100                 105                 110         


Arg Cys Thr Ser Pro Gly Gly Ser Tyr Gly His Leu Ser Ile Gly Thr 
        115                 120                 125             


Met Ser Pro Ser Leu Gly Phe Pro Ala Gln Met Asn His Gln Lys Gly 
    130                 135                 140                 


Pro Ser Pro Ser Phe Gly Val Gln Pro Cys Gly Pro His Asp Ser Ala 
145                 150                 155                 160 


Arg Gly Gly Met Ile Pro His Pro Gln Ser Arg Gly Pro Phe Pro Thr 
                165                 170                 175     


Cys Gln Leu Lys Ser Glu Leu Asp Met Leu Val Gly Lys Cys Arg Glu 
            180                 185                 190         


Glu Pro Leu Glu Gly Asp Met Ser Ser Pro Asn Ser Thr Gly Ile Gln 
        195                 200                 205             


Asp Pro Leu Leu Gly Met Leu Asp Gly Arg Glu Asp Leu Glu Arg Glu 
    210                 215                 220                 


Glu Lys Arg Glu Pro Glu Ser Val Tyr Glu Thr Asp Cys Arg Trp Asp 
225                 230                 235                 240 


Gly Cys Ser Gln Glu Phe Asp Ser Gln Glu Gln Leu Val His His Ile 
                245                 250                 255     


Asn Ser Glu His Ile His Gly Glu Arg Lys Glu Phe Val Cys His Trp 
            260                 265                 270         


Gly Gly Cys Ser Arg Glu Leu Arg Pro Phe Lys Ala Gln Tyr Met Leu 
        275                 280                 285             


Val Val His Met Arg Arg His Thr Gly Glu Lys Pro His Lys Cys Thr 
    290                 295                 300                 


Phe Glu Gly Cys Arg Lys Ser Tyr Ser Arg Leu Glu Asn Leu Lys Thr 
305                 310                 315                 320 


His Leu Arg Ser His Thr Gly Glu Lys Pro Tyr Met Cys Glu His Glu 
                325                 330                 335     


Gly Cys Ser Lys Ala Phe Ser Asn Ala Ser Asp Arg Ala Lys His Gln 
            340                 345                 350         


Asn Arg Thr His Ser Asn Glu Lys Pro Tyr Val Cys Lys Leu Pro Gly 
        355                 360                 365             


Cys Thr Lys Arg Tyr Thr Asp Pro Ser Ser Leu Arg Lys His Val Lys 
    370                 375                 380                 


Thr Val His Gly Pro Asp Ala His Val Thr Lys Arg His Arg Gly Asp 
385                 390                 395                 400 


Gly Pro Leu Pro Arg Ala Pro Ser Ile Ser Thr Val Glu Pro Lys Arg 
                405                 410                 415     


Glu Arg Glu Gly Gly Pro Ile Arg Glu Glu Ser Arg Leu Thr Val Pro 
            420                 425                 430         


Glu Gly Ala Met Lys Pro Gln Pro Ser Pro Gly Ala Gln Ser Ser Cys 
        435                 440                 445             


Ser Ser Asp His Ser Pro Ala Gly Ser Ala Ala Asn Thr Asp Ser Gly 
    450                 455                 460                 


Val Glu Met Thr Gly Asn Ala Gly Gly Ser Thr Glu Asp Leu Ser Ser 
465                 470                 475                 480 


Leu Asp Glu Gly Pro Cys Ile Ala Gly Thr Gly Leu Ser Thr Leu Arg 
                485                 490                 495     


Arg Leu Glu Asn Leu Arg Leu Asp Gln Leu His Gln Leu Arg Pro Ile 
            500                 505                 510         


Gly Thr Arg Gly Leu Lys Leu Pro Ser Leu Ser His Thr Gly Thr Thr 
        515                 520                 525             


Val Ser Arg Arg Val Gly Pro Pro Val Ser Leu Glu Arg Arg Ser Ser 
    530                 535                 540                 


Ser Ser Ser Ser Ile Ser Ser Ala Tyr Thr Val Ser Arg Arg Ser Ser 
545                 550                 555                 560 


Leu Ala Ser Pro Phe Pro Pro Gly Ser Pro Pro Glu Asn Gly Ala Ser 
                565                 570                 575     


Ser Leu Pro Gly Leu Met Pro Ala Gln His Tyr Leu Leu Arg Ala Arg 
            580                 585                 590         


Tyr Ala Ser Ala Arg Gly Gly Gly Thr Ser Pro Thr Ala Ala Ser Ser 
        595                 600                 605             


Leu Asp Arg Ile Gly Gly Leu Pro Met Pro Pro Trp Arg Ser Arg Ala 
    610                 615                 620                 


Glu Tyr Pro Gly Tyr Asn Pro Asn Ala Gly Val Thr Arg Arg Ala Ser 
625                 630                 635                 640 


Asp Pro Ala Gln Ala Ala Asp Arg Pro Ala Pro Ala Arg Val Gln Arg 
                645                 650                 655     


Phe Lys Ser Leu Gly Cys Val His Thr Pro Pro Thr Val Ala Gly Gly 
            660                 665                 670         


Gly Gln Asn Phe Asp Pro Tyr Leu Pro Thr Ser Val Tyr Ser Pro Gln 
        675                 680                 685             


Pro Pro Ser Ile Thr Glu Asn Ala Ala Met Asp Ala Arg Gly Leu Gln 
    690                 695                 700                 


Glu Glu Pro Glu Val Gly Thr Ser Met Val Gly Ser Gly Leu Asn Pro 
705                 710                 715                 720 


Tyr Met Asp Phe Pro Pro Thr Asp Thr Leu Gly Tyr Gly Gly Pro Glu 
                725                 730                 735     


Gly Ala Ala Ala Glu Pro Tyr Gly Ala Arg Gly Pro Gly Ser Leu Pro 
            740                 745                 750         


Leu Gly Pro Gly Pro Pro Thr Asn Tyr Gly Pro Asn Pro Cys Pro Gln 
        755                 760                 765             


Gln Ala Ser Tyr Pro Asp Pro Thr Gln Glu Thr Trp Gly Glu Phe Pro 
    770                 775                 780                 


Ser His Ser Gly Leu Tyr Pro Gly Pro Lys Ala Leu Gly Gly Thr Tyr 
785                 790                 795                 800 


Ser Gln Cys Pro Arg Leu Glu His Tyr Gly Gln Val Gln Val Lys Pro 
                805                 810                 815     


Glu Gln Gly Cys Pro Val Gly Ser Asp Ser Thr Gly Leu Ala Pro Cys 
            820                 825                 830         


Leu Asn Ala His Pro Ser Glu Gly Pro Pro His Pro Gln Pro Leu Phe 
        835                 840                 845             


Ser His Tyr Pro Gln Pro Ser Pro Pro Gln Tyr Leu Gln Ser Gly Pro 
    850                 855                 860                 


Tyr Thr Gln Pro Pro Pro Asp Tyr Leu Pro Ser Glu Pro Arg Pro Cys 
865                 870                 875                 880 


Leu Asp Phe Asp Ser Pro Thr His Ser Thr Gly Gln Leu Lys Ala Gln 
                885                 890                 895     


Leu Val Cys Asn Tyr Val Gln Ser Gln Gln Glu Leu Leu Trp Glu Gly 
            900                 905                 910         


Gly Gly Arg Glu Asp Ala Pro Ala Gln Glu Pro Ser Tyr Gln Ser Pro 
        915                 920                 925             


Lys Phe Leu Gly Gly Ser Gln Val Ser Pro Ser Arg Ala Lys Ala Pro 
    930                 935                 940                 


Val Asn Thr Tyr Gly Pro Gly Phe Gly Pro Asn Leu Pro Asn His Lys 
945                 950                 955                 960 


Ser Gly Ser Tyr Pro Thr Pro Ser Pro Cys His Glu Asn Phe Val Val 
                965                 970                 975     


Gly Ala Asn Arg Ala Ser His Arg Ala Ala Ala Pro Pro Arg Leu Leu 
            980                 985                 990         


Pro Pro Leu Pro Thr Cys Tyr Gly  Pro Leu Lys Val Gly  Gly Thr Asn 
        995                 1000                 1005             


Pro Ser  Cys Gly His Pro Glu  Val Gly Arg Leu Gly  Gly Gly Pro 
    1010                 1015                 1020             


Ala Leu  Tyr Pro Pro Pro Glu  Gly Gln Val Cys Asn  Pro Leu Asp 
    1025                 1030                 1035             


Ser Leu  Asp Leu Asp Asn Thr  Gln Leu Asp Phe Val  Ala Ile Leu 
    1040                 1045                 1050             


Asp Glu  Pro Gln Gly Leu Ser  Pro Pro Pro Ser His  Asp Gln Arg 
    1055                 1060                 1065             


Gly Ser  Ser Gly His Thr Pro  Pro Pro Ser Gly Pro  Pro Asn Met 
    1070                 1075                 1080             


Ala Val  Gly Asn Met Ser Val  Leu Leu Arg Ser Leu  Pro Gly Glu 
    1085                 1090                 1095             


Thr Glu  Phe Leu Asn Ser Ser  Ala 
    1100                 1105     


<210>  4
<211>  3600
<212>  DNA
<213>  Human

<400>  4
cccagactcc agccctggac cgcgcatccc gagcccagcg cccagacaga gtgtccccac       60

accctcctct gagacgccat gttcaactcg atgaccccac caccaatcag tagctatggc      120

gagccctgct gtctccggcc cctccccagt cagggggccc ccagtgtggg gacagaagga      180

ctgtctggcc cgcccttctg ccaccaagct aacctcatgt ccggccccca cagttatggg      240

ccagccagag agaccaacag ctgcaccgag ggcccactct tttcttctcc ccggagtgca      300

gtcaagttga ccaagaagcg ggcactgtcc atctcacctc tgtcggatgc cagcctggac      360

ctgcagacgg ttatccgcac ctcacccagc tccctcgtag ctttcatcaa ctcgcgatgc      420

acatctccag gaggctccta cggtcatctc tccattggca ccatgagccc atctctggga      480

ttcccagccc agatgaatca ccaaaaaggg ccctcgcctt cctttggggt ccagccttgt      540

ggtccccatg actctgcccg gggtgggatg atcccacatc ctcagtcccg gggacccttc      600

ccaacttgcc agctgaagtc tgagctggac atgctggttg gcaagtgccg ggaggaaccc      660

ttggaaggtg atatgtccag ccccaactcc acaggcatac aggatcccct gttggggatg      720

ctggatgggc gggaggacct cgagagagag gagaagcgtg agcctgaatc tgtgtatgaa      780

actgactgcc gttgggatgg ctgcagccag gaatttgact cccaagagca gctggtgcac      840

cacatcaaca gcgagcacat ccacggggag cggaaggagt tcgtgtgcca ctgggggggc      900

tgctccaggg agctgaggcc cttcaaagcc cagtacatgc tggtggttca catgcgcaga      960

cacactggcg agaagccaca caagtgcacg tttgaagggt gccggaagtc atactcacgc     1020

ctcgaaaacc tgaagacgca cctgcggtca cacacgggtg agaagccata catgtgtgag     1080

cacgagggct gcagtaaagc cttcagcaat gccagtgacc gagccaagca ccagaatcgg     1140

acccattcca atgagaagcc gtatgtatgt aagctccctg gctgcaccaa acgctataca     1200

gatcctagct cgctgcgaaa acatgtcaag acagtgcatg gtcctgacgc ccatgtgacc     1260

aaacggcacc gtggggatgg ccccctgcct cgggcaccat ccatttctac agtggagccc     1320

aagagggagc gggaaggagg tcccatcagg gaggaaagca gactgactgt gccagagggt     1380

gccatgaagc cacagccaag ccctggggcc cagtcatcct gcagcagtga ccactccccg     1440

gcagggagtg cagccaatac agacagtggt gtggaaatga ctggcaatgc agggggcagc     1500

actgaagacc tctccagctt ggacgaggga ccttgcattg ctggcactgg tctgtccact     1560

cttcgccgcc ttgagaacct caggctggac cagctacatc aactccggcc aatagggacc     1620

cggggtctca aactgcccag cttgtcccac accggtacca ctgtgtcccg ccgcgtgggc     1680

cccccagtct ctcttgaacg ccgcagcagc agctccagca gcatcagctc tgcctatact     1740

gtcagccgcc gctcctccct ggcctctcct ttcccccctg gctccccacc agagaatgga     1800

gcatcctccc tgcctggcct tatgcctgcc cagcactacc tgcttcgggc aagatatgct     1860

tcagccagag ggggtggtac ttcgcccact gcagcatcca gcctggatcg gataggtggt     1920

cttcccatgc ctccttggag aagccgagcc gagtatccag gatacaaccc caatgcaggg     1980

gtcacccgga gggccagtga cccagcccag gctgctgacc gtcctgctcc agctagagtc     2040

cagaggttca agagcctggg ctgtgtccat accccaccca ctgtggcagg gggaggacag     2100

aactttgatc cttacctccc aacctctgtc tactcaccac agccccccag catcactgag     2160

aatgctgcca tggatgctag agggctacag gaagagccag aagttgggac ctccatggtg     2220

ggcagtggtc tgaaccccta tatggacttc ccacctactg atactctggg atatggggga     2280

cctgaagggg cagcagctga gccttatgga gcgaggggtc caggctctct gcctcttggg     2340

cctggtccac ccaccaacta tggccccaac ccctgtcccc agcaggcctc atatcctgac     2400

cccacccaag aaacatgggg tgagttccct tcccactctg ggctgtaccc aggccccaag     2460

gctctaggtg gaacctacag ccagtgtcct cgacttgaac attatggaca agtgcaagtc     2520

aagccagaac aggggtgccc agtggggtct gactccacag gactggcacc ctgcctcaat     2580

gcccacccca gtgaggggcc cccacatcca cagcctctct tttcccatta cccccagccc     2640

tctcctcccc aatatctcca gtcaggcccc tatacccagc caccccctga ttatcttcct     2700

tcagaaccca ggccttgcct ggactttgat tcccccaccc attccacagg gcagctcaag     2760

gctcagcttg tgtgtaatta tgttcaatct caacaggagc tactgtggga gggtgggggc     2820

agggaagatg cccccgccca ggaaccttcc taccagagtc ccaagtttct ggggggttcc     2880

caggttagcc caagccgtgc taaagctcca gtgaacacat atggacctgg ctttggaccc     2940

aacttgccca atcacaagtc aggttcctat cccacccctt caccatgcca tgaaaatttt     3000

gtagtggggg caaatagggc ttcacatagg gcagcagcac cacctcgact tctgccccca     3060

ttgcccactt gctatgggcc tctcaaagtg ggaggcacaa accccagctg tggtcatcct     3120

gaggtgggca ggctaggagg gggtcctgcc ttgtaccctc ctcccgaagg acaggtatgt     3180

aaccccctgg actctcttga tcttgacaac actcagctgg actttgtggc tattctggat     3240

gagccccagg ggctgagtcc tcctccttcc catgatcagc ggggcagctc tggacatacc     3300

ccacctccct ctgggccccc caacatggct gtgggcaaca tgagtgtctt actgagatcc     3360

ctacctgggg aaacagaatt cctcaactct agtgcctaaa gagtagggaa tctcatccat     3420

cacagatcgc atttcctaag gggtttctat ccttccagaa aaattggggg agctgcagtc     3480

ccctgcacaa gatgccccag ggatgggagg tatgggctgg gggctatgta tagtctgtat     3540

acgttttgag gagaaatttg ataatgacac tgtttcctga taataaagga actgcatcag     3600


<210>  5
<211>  551
<212>  PRT
<213>  Human

<400>  5

Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala Glu Pro Ala Gln Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Val Pro 
    130                 135                 140                 


Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys 
145                 150                 155                 160 


Phe Gln Val Thr Val Arg Asp Pro Ser Gly Arg Pro Leu Arg Leu Pro 
                165                 170                 175     


Pro Val Leu Pro His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr Ala 
            180                 185                 190         


Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu Gly 
        195                 200                 205             


Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile 
    210                 215                 220                 


Glu Val Tyr Phe Thr Gly Pro Gly Trp Glu Ala Arg Gly Ser Phe Ser 
225                 230                 235                 240 


Gln Ala Asp Val His Arg Gln Val Ala Ile Val Phe Arg Thr Pro Pro 
                245                 250                 255     


Tyr Ala Asp Pro Ser Leu Gln Ala Pro Val Arg Val Ser Met Gln Leu 
            260                 265                 270         


Arg Arg Pro Ser Asp Arg Glu Leu Ser Glu Pro Met Glu Phe Gln Tyr 
        275                 280                 285             


Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg 
    290                 295                 300                 


Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly 
305                 310                 315                 320 


Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg 
                325                 330                 335     


Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr 
            340                 345                 350         


Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe 
        355                 360                 365             


Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro 
    370                 375                 380                 


Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val 
385                 390                 395                 400 


Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly 
                405                 410                 415     


Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly 
            420                 425                 430         


Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu 
        435                 440                 445             


Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr 
    450                 455                 460                 


Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln 
465                 470                 475                 480 


Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr 
                485                 490                 495     


Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp 
            500                 505                 510         


Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu 
        515                 520                 525             


Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala 
    530                 535                 540                 


Leu Leu Ser Gln Ile Ser Ser 
545                 550     


<210>  6
<211>  1760
<212>  DNA
<213>  Human

<400>  6
ggcgaatggc tcgtctgtag tgcacgccgc gggcccagct gcgaccccgg ccccgccccc       60

gggaccccgg ccatggacga actgttcccc ctcatcttcc cggcagagcc agcccaggcc      120

tctggcccct atgtggagat cattgagcag cccaagcagc ggggcatgcg cttccgctac      180

aagtgcgagg ggcgctccgc gggcagcatc ccaggcgaga ggagcacaga taccaccaag      240

acccacccca ccatcaagat caatggctac acaggaccag ggacagtgcg catctccctg      300

gtcaccaagg accctcctca ccggcctcac ccccacgagc ttgtaggaaa ggactgccgg      360

gatggcttct atgaggctga gctctgcccg gaccgctgca tccacagttt ccagaacctg      420

ggaatccagt gtgtgaagaa gcgggacctg gagcaggcta tcagtcagcg catccagacc      480

aacaacaacc ccttccaagt tcctatagaa gagcagcgtg gggactacga cctgaatgct      540

gtgcggctct gcttccaggt gacagtgcgg gacccatcag gcaggcccct ccgcctgccg      600

cctgtccttc ctcatcccat ctttgacaat cgtgccccca acactgccga gctcaagatc      660

tgccgagtga accgaaactc tggcagctgc ctcggtgggg atgagatctt cctactgtgt      720

gacaaggtgc agaaagagga cattgaggtg tatttcacgg gaccaggctg ggaggcccga      780

ggctcctttt cgcaagctga tgtgcaccga caagtggcca ttgtgttccg gacccctccc      840

tacgcagacc ccagcctgca ggctcctgtg cgtgtctcca tgcagctgcg gcggccttcc      900

gaccgggagc tcagtgagcc catggaattc cagtacctgc cagatacaga cgatcgtcac      960

cggattgagg agaaacgtaa aaggacatat gagaccttca agagcatcat gaagaagagt     1020

cctttcagcg gacccaccga cccccggcct ccacctcgac gcattgctgt gccttcccgc     1080

agctcagctt ctgtccccaa gccagcaccc cagccctatc cctttacgtc atccctgagc     1140

accatcaact atgatgagtt tcccaccatg gtgtttcctt ctgggcagat cagccaggcc     1200

tcggccttgg ccccggcccc tccccaagtc ctgccccagg ctccagcccc tgcccctgct     1260

ccagccatgg tatcagctct ggcccaggcc ccagcccctg tcccagtcct agccccaggc     1320

cctcctcagg ctgtggcccc acctgccccc aagcccaccc aggctgggga aggaacgctg     1380

tcagaggccc tgctgcagct gcagtttgat gatgaagacc tgggggcctt gcttggcaac     1440

agcacagacc cagctgtgtt cacagacctg gcatccgtcg acaactccga gtttcagcag     1500

ctgctgaacc agggcatacc tgtggccccc cacacaactg agcccatgct gatggagtac     1560

cctgaggcta taactcgcct agtgacaggg gcccagaggc cccccgaccc agctcctgct     1620

ccactggggg ccccggggct ccccaatggc ctcctttcag gagatgaaga cttctcctcc     1680

attgcggaca tggacttctc agccctgctg agtcagatca gctcctaagg gggtgacgcc     1740

tgccctcccc agagcactgg                                                 1760


<210>  7
<211>  579
<212>  PRT
<213>  Human

<400>  7

Met Leu Arg Ser Gly Pro Ala Ser Gly Pro Ser Val Pro Thr Gly Arg 
1               5                   10                  15      


Ala Met Pro Ser Arg Arg Val Ala Arg Pro Pro Ala Ala Pro Glu Leu 
            20                  25                  30          


Gly Ala Leu Gly Ser Pro Asp Leu Ser Ser Leu Ser Leu Ala Val Ser 
        35                  40                  45              


Arg Ser Thr Asp Glu Leu Glu Ile Ile Asp Glu Tyr Ile Lys Glu Asn 
    50                  55                  60                  


Gly Phe Gly Leu Asp Gly Gly Gln Pro Gly Pro Gly Glu Gly Leu Pro 
65                  70                  75                  80  


Arg Leu Val Ser Arg Gly Ala Ala Ser Leu Ser Thr Val Thr Leu Gly 
                85                  90                  95      


Pro Val Ala Pro Pro Ala Thr Pro Pro Pro Trp Gly Cys Pro Leu Gly 
            100                 105                 110         


Arg Leu Val Ser Pro Ala Pro Gly Pro Gly Pro Gln Pro His Leu Val 
        115                 120                 125             


Ile Thr Glu Gln Pro Lys Gln Arg Gly Met Arg Phe Arg Tyr Glu Cys 
    130                 135                 140                 


Glu Gly Arg Ser Ala Gly Ser Ile Leu Gly Glu Ser Ser Thr Glu Ala 
145                 150                 155                 160 


Ser Lys Thr Leu Pro Ala Ile Glu Leu Arg Asp Cys Gly Gly Leu Arg 
                165                 170                 175     


Glu Val Glu Val Thr Ala Cys Leu Val Trp Lys Asp Trp Pro His Arg 
            180                 185                 190         


Val His Pro His Ser Leu Val Gly Lys Asp Cys Thr Asp Gly Ile Cys 
        195                 200                 205             


Arg Val Arg Leu Arg Pro His Val Ser Pro Arg His Ser Phe Asn Asn 
    210                 215                 220                 


Leu Gly Ile Gln Cys Val Arg Lys Lys Glu Ile Glu Ala Ala Ile Glu 
225                 230                 235                 240 


Arg Lys Ile Gln Leu Gly Ile Asp Pro Tyr Asn Ala Gly Ser Leu Lys 
                245                 250                 255     


Asn His Gln Glu Val Asp Met Asn Val Val Arg Ile Cys Phe Gln Ala 
            260                 265                 270         


Ser Tyr Arg Asp Gln Gln Gly Gln Met Arg Arg Met Asp Pro Val Leu 
        275                 280                 285             


Ser Glu Pro Val Tyr Asp Lys Lys Ser Thr Asn Thr Ser Glu Leu Arg 
    290                 295                 300                 


Ile Cys Arg Ile Asn Lys Glu Ser Gly Pro Cys Thr Gly Gly Glu Glu 
305                 310                 315                 320 


Leu Tyr Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile Ser Val Val 
                325                 330                 335     


Phe Ser Arg Ala Ser Trp Glu Gly Arg Ala Asp Phe Ser Gln Ala Asp 
            340                 345                 350         


Val His Arg Gln Ile Ala Ile Val Phe Lys Thr Pro Pro Tyr Glu Asp 
        355                 360                 365             


Leu Glu Ile Val Glu Pro Val Thr Val Asn Val Phe Leu Gln Arg Leu 
    370                 375                 380                 


Thr Asp Gly Val Cys Ser Glu Pro Leu Pro Phe Thr Tyr Leu Pro Arg 
385                 390                 395                 400 


Asp His Asp Ser Tyr Gly Val Asp Lys Lys Arg Lys Arg Gly Met Pro 
                405                 410                 415     


Asp Val Leu Gly Glu Leu Asn Ser Ser Asp Pro His Gly Ile Glu Ser 
            420                 425                 430         


Lys Arg Arg Lys Lys Lys Pro Ala Ile Leu Asp His Phe Leu Pro Asn 
        435                 440                 445             


His Gly Ser Gly Pro Phe Leu Pro Pro Ser Ala Leu Leu Pro Asp Pro 
    450                 455                 460                 


Asp Phe Phe Ser Gly Thr Val Ser Leu Pro Gly Leu Glu Pro Pro Gly 
465                 470                 475                 480 


Gly Pro Asp Leu Leu Asp Asp Gly Phe Ala Tyr Asp Pro Thr Ala Pro 
                485                 490                 495     


Thr Leu Phe Thr Met Leu Asp Leu Leu Pro Pro Ala Pro Pro His Ala 
            500                 505                 510         


Ser Ala Val Val Cys Ser Gly Gly Ala Gly Ala Val Val Gly Glu Thr 
        515                 520                 525             


Pro Gly Pro Glu Pro Leu Thr Leu Asp Ser Tyr Gln Ala Pro Gly Pro 
    530                 535                 540                 


Gly Asp Gly Gly Thr Ala Ser Leu Val Gly Ser Asn Met Phe Pro Asn 
545                 550                 555                 560 


His Tyr Arg Glu Ala Ala Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro 
                565                 570                 575     


Glu Ala Thr 
            


<210>  8
<211>  2287
<212>  DNA
<213>  Human

<400>  8
cgcgccccgc gcagccccgg gcgccgcgcg tcctgcccgg cctgcggccc cagcccttgc       60

gccgctcgtc cgacccgcga tcgtccacca gaccgtgcct cccggccgcc cggccggccc      120

gcgtgcatgc ttcggtctgg gccagcctct gggccgtccg tccccactgg ccgggccatg      180

ccgagtcgcc gcgtcgccag accgccggct gcgccggagc tgggggcctt agggtccccc      240

gacctctcct cactctcgct cgccgtttcc aggagcacag atgaattgga gatcatcgac      300

gagtacatca aggagaacgg cttcggcctg gacgggggac agccgggccc gggcgagggg      360

ctgccacgcc tggtgtctcg cggggctgcg tccctgagca cggtcaccct gggccctgtg      420

gcgcccccag ccacgccgcc gccttggggc tgccccctgg gccgactagt gtccccagcg      480

ccgggcccgg gcccgcagcc gcacctggtc atcacggagc agcccaagca gcgcggcatg      540

cgcttccgct acgagtgcga gggccgctcg gccggcagca tccttgggga gagcagcacc      600

gaggccagca agacgctgcc cgccatcgag ctccgggatt gtggagggct gcgggaggtg      660

gaggtgactg cctgcctggt gtggaaggac tggcctcacc gagtccaccc ccacagcctc      720

gtggggaaag actgcaccga cggcatctgc agggtgcggc tccggcctca cgtcagcccc      780

cggcacagtt ttaacaacct gggcatccag tgtgtgagga agaaggagat tgaggctgcc      840

attgagcgga agattcaact gggcattgac ccctacaacg ctgggtccct gaagaaccat      900

caggaagtag acatgaatgt ggtgaggatc tgcttccagg cctcatatcg ggaccagcag      960

ggacagatgc gccggatgga tcctgtgctt tccgagcccg tctatgacaa gaaatccaca     1020

aacacatcag agctgcggat ttgccgaatt aacaaggaaa gcgggccgtg caccggtggc     1080

gaggagctct acttgctctg cgacaaggtg cagaaagagg acatatcagt ggtgttcagc     1140

agggcctcct gggaaggtcg ggctgacttc tcccaggccg acgtgcaccg ccagattgcc     1200

attgtgttca agacgccgcc ctacgaggac ctggagattg tcgagcccgt gacagtcaac     1260

gtcttcctgc agcggctcac cgatggggtc tgcagcgagc cattgccttt cacgtacctg     1320

cctcgcgacc atgacagcta cggcgtggac aagaagcgga aacgggggat gcccgacgtc     1380

cttggggagc tgaacagctc tgacccccat ggcatcgaga gcaaacggcg gaagaaaaag     1440

ccggccatcc tggaccactt cctgcccaac cacggctcag gcccgttcct cccgccgtca     1500

gccctgctgc cagaccctga cttcttctct ggcaccgtgt ccctgcccgg cctggagccc     1560

cctggcgggc ctgacctcct ggacgatggc tttgcctacg accctacggc ccccacactc     1620

ttcaccatgc tggacctgct gcccccggca ccgccacacg ctagcgctgt tgtgtgcagc     1680

ggaggtgccg gggccgtggt tggggagacc cccggccctg aaccactgac actggactcg     1740

taccaggccc cgggccccgg ggatggaggc accgccagcc ttgtgggcag caacatgttc     1800

cccaatcatt accgcgaggc ggcctttggg ggcggcctcc tatccccggg gcctgaagcc     1860

acgtagcccc gcgatgccag aggaggggca ctgggtgggg agggaggtgg aggagccgtg     1920

caatcccaac caggatgtct agcaccccca tccccttggc ccttcctcat gcttctgaag     1980

tggacatatt cagccttggc gagaagctcc gttgcacggg tttccccttg agcccatttt     2040

acagatgagg aaactgagtc cggagaggaa aagggacatg gctcccgtgc actagcttgt     2100

tacagctgcc tctgtcccca catgtggggg caccttctcc agtaggattc ggaaaagatt     2160

gtacatatgg gaggaggggg cagattcctg gccctccctc cccagacttg aaggtggggg     2220

gtaggttggt tgttcagagt cttcccaata aagatgagtt tttgagcctc aaaaaaaaaa     2280

aaaaaaa                                                               2287


