                         SUBSTITUTE SEQUENCE LISTING

<110>  Medimmune LLC
       McAuliffe, Josephine
       Palmer-Hill, Frances
       Zhu, Qing
       Suzich, JoAnn
 
<120>  Antibodies Against and Methods for Producing Vaccines to 
       Respiratory Syncytial Virus

<130>  RS200PCT2

<140>  PCT/US2009/069406
<141>  2009-12-23

<150>  US 61/149,173
<151>  2009-02-02

<160>  40    

<170>  PatentIn version 3.3

<210>  1
<211>  24
<212>  PRT
<213>  respiratory syncytial virus

<400>  1

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  2
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  2

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Arg Leu Met Ser Asn Asn 
            20                  


<210>  3
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  3

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Gln Leu Met Ser Asn Asn 
            20                  


<210>  4
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  4

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Thr Leu Met Ser Asn Asn 
            20                  


<210>  5
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  5

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Glu Leu Met Ser Asn Asn 
            20                  


<210>  6
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  6

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Asp Leu Met Ser Asn Asn 
            20                  


<210>  7
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  7

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Met Leu Met Ser Asn Asn 
            20                  


<210>  8
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  8

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys His Leu Met Ser Asn Asn 
            20                  


<210>  9
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  9

Asn Ser Glu Leu Leu Ser Leu Ile Gln Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  10
<211>  24
<212>  PRT
<213>  respiratory syncytial virus

<400>  10

Asn Ser Glu Leu Leu Ser Leu Ile Tyr Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  11
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  11

Asn Ser Glu Leu Leu Ser Leu Ile Lys Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  12
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  12

Asn Ser Glu Leu Leu Ser Leu Ile Asp Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  13
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  13

Asn Ser Glu Leu Leu Ser Leu Ile His Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  14
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  14

Asn Ser Glu Leu Leu Ser Leu Ile Arg Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  15
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  15

Asn Ser Glu Leu Leu Ser Leu Ile Ser Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  16
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  16

Asn Ser Glu Leu Leu Ser Leu Ile Ala Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  17
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  17

Asn Ser Glu Leu Ser Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  18
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  18

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Tyr Leu Met Ser Asn Asn 
            20                  


<210>  19
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  19

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Ile Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  20
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  20

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Asn Leu Met Ser Asn Asn 
            20                  


<210>  21
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  21

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Phe Asn Asn 
            20                  


<210>  22
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  22

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Glu Asn 
            20                  


<210>  23
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  23

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Tyr Asn 
            20                  


<210>  24
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn Xaa Xaa Cys 
            20                  25          


<210>  25
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  25

Asn Ser Glu Leu Leu Ser Leu Ile His Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln 
            20                  25                  30  


<210>  26
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  26

Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile His Asp 
1               5                   10                  15      


Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn 
            20                  25                  30  


<210>  27
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  27

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn Cys Asn His 
            20                  25          


<210>  28
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  28

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn Asn His 
            20                  25      


<210>  29
<211>  575
<212>  PRT
<213>  respiratory syncytial virus F protein

<400>  29

Met Glu Leu Pro Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Thr Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Cys Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Cys Ile 
            420                 425                 430         


Ile Lys Thr Phe Ser Asn Gly Cys Asp Tyr Ala Ser Asn Lys Gly Val 
        435                 440                 445             


Asp Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu 
    450                 455                 460                 


Gly Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Thr 
465                 470                 475                 480 


Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val 
                485                 490                 495     


Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu 
            500                 505                 510         


Leu Leu His His Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile 
        515                 520                 525             


Thr Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala 
    530                 535                 540                 


Val Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu 
545                 550                 555                 560 


Ser Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 575 


<210>  30
<211>  106
<212>  PRT
<213>  Chimaera sp.

<220>
<223>  Humanized VL domain antibody sequence

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Cys Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  31
<211>  120
<212>  PRT
<213>  Chimaera sp.

<220>
<223>  Humanized VH domain antibody sequence

<400>  31

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  32
<211>  106
<212>  PRT
<213>  Chimaera sp.

<220>
<223>  Humanized VL domain antibody sequence

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Phe Phe Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  33
<211>  120
<212>  PRT
<213>  Chimaera sp.

<220>
<223>  Humanized VH domain antibody sequence

<400>  33

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  34

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Glu Asn 
            20              


<210>  35
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  35

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Leu Asp 
1               5                   10                  15      


Gln Lys Ile Leu Met Ser Ser 
            20          	 


<210>  36
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Derived from respiratory syncytial virus sequence

<400>  36

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Asn Leu Met Ser Ser 
            20                                


<210>  37
<211>  23
<212>  PRT
<213>  Artificial sequence

<223>  Derived from respiratory syncytial virus sequence

<400>  37

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Ile Leu Met Ser Ser
            20          


<210>  38
<211>  23
<212>  PRT
<213>  Artificial sequence

<223>  Derived from respiratory syncytial virus sequence

<400>  38

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Gln Leu Met Ser Ser
            20          


<210>  39
<211>  19
<212>  PRT
<213>  Artificial sequence

<223>  Derived from respiratory syncytial virus sequence

<400>  39

Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Leu Asp Gln Lys Ile
1               5                   10                  15      


Leu Met Ser Ser
            


<210>  40
<211>  19
<212>  PRT
<213>  Artificial sequence

<223>  Derived from respiratory syncytial virus sequence

<400>  40

Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Ile
1               5                   10                  15      


Leu Met Ser Ser
            
        

