                         SEQUENCE LISTING

<110>  Institut Curie
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
 
<120>  TSLP promotes immune evasion and persistence of viruses

<130>  BET 09P1916

<150>  EP 09305092.0
<151>  2009-01-30

<160>  5     

<170>  PatentIn version 3.4

<210>  1
<211>  743
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(743)
<223>  thymic stromal lymphopoietin (TSLP)

<220>
<221>  CDS
<222>  (200)..(679)

<400>  1
gcagccagaa agctctggag catcagggag actccaactt aaggcaacag catgggtgaa     60

taagggcttc ctgtggactg gcaatgagag gcaaaacctg gtgcttgagc actggcccct    120

aaggcaggcc ttacagatct cttacactcg tggtgggaag agtttagtgt gaaactgggg    180

tggaattggg tgtccacgt atg ttc cct ttt gcc tta cta tat gtt ctg tca     232
                     Met Phe Pro Phe Ala Leu Leu Tyr Val Leu Ser        
                     1               5                   10             

gtt tct ttc agg aaa atc ttc atc tta caa ctt gta ggg ctg gtg tta      280
Val Ser Phe Arg Lys Ile Phe Ile Leu Gln Leu Val Gly Leu Val Leu         
            15                  20                  25                  

act tac gac ttc act aac tgt gac ttt gag aag att aaa gca gcc tat      328
Thr Tyr Asp Phe Thr Asn Cys Asp Phe Glu Lys Ile Lys Ala Ala Tyr         
        30                  35                  40                      

ctc agt act att tct aaa gac ctg att aca tat atg agt ggg acc aaa      376
Leu Ser Thr Ile Ser Lys Asp Leu Ile Thr Tyr Met Ser Gly Thr Lys         
    45                  50                  55                          

agt acc gag ttc aac aac acc gtc tct tgt agc aat cgg cca cat tgc      424
Ser Thr Glu Phe Asn Asn Thr Val Ser Cys Ser Asn Arg Pro His Cys         
60                  65                  70                  75          

ctt act gaa atc cag agc cta acc ttc aat ccc acc gcc ggc tgc gcg      472
Leu Thr Glu Ile Gln Ser Leu Thr Phe Asn Pro Thr Ala Gly Cys Ala         
                80                  85                  90              

tcg ctc gcc aaa gaa atg ttc gcc atg aaa act aag gct gcc tta gct      520
Ser Leu Ala Lys Glu Met Phe Ala Met Lys Thr Lys Ala Ala Leu Ala         
            95                  100                 105                 

atc tgg tgc cca ggc tat tcg gaa act cag ata aat gct act cag gca      568
Ile Trp Cys Pro Gly Tyr Ser Glu Thr Gln Ile Asn Ala Thr Gln Ala         
        110                 115                 120                     

atg aag aag agg aga aaa agg aaa gtc aca acc aat aaa tgt ctg gaa      616
Met Lys Lys Arg Arg Lys Arg Lys Val Thr Thr Asn Lys Cys Leu Glu         
    125                 130                 135                         

caa gtg tca caa tta caa gga ttg tgg cgt cgc ttc aat cga cct tta      664
Gln Val Ser Gln Leu Gln Gly Leu Trp Arg Arg Phe Asn Arg Pro Leu         
140                 145                 150                 155         

ctg aaa caa cag taa accatcttta ttatggtcat atttcacagc ccaaaataaa      719
Leu Lys Gln Gln                                                         
                                                                        

tcatctttat taagtaaaaa aaaa                                           743


<210>  2
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Phe Pro Phe Ala Leu Leu Tyr Val Leu Ser Val Ser Phe Arg Lys 
1               5                   10                  15      


Ile Phe Ile Leu Gln Leu Val Gly Leu Val Leu Thr Tyr Asp Phe Thr 
            20                  25                  30          


Asn Cys Asp Phe Glu Lys Ile Lys Ala Ala Tyr Leu Ser Thr Ile Ser 
        35                  40                  45              


Lys Asp Leu Ile Thr Tyr Met Ser Gly Thr Lys Ser Thr Glu Phe Asn 
    50                  55                  60                  


Asn Thr Val Ser Cys Ser Asn Arg Pro His Cys Leu Thr Glu Ile Gln 
65                  70                  75                  80  


Ser Leu Thr Phe Asn Pro Thr Ala Gly Cys Ala Ser Leu Ala Lys Glu 
                85                  90                  95      


Met Phe Ala Met Lys Thr Lys Ala Ala Leu Ala Ile Trp Cys Pro Gly 
            100                 105                 110         


Tyr Ser Glu Thr Gln Ile Asn Ala Thr Gln Ala Met Lys Lys Arg Arg 
        115                 120                 125             


Lys Arg Lys Val Thr Thr Asn Lys Cys Leu Glu Gln Val Ser Gln Leu 
    130                 135                 140                 


Gln Gly Leu Trp Arg Arg Phe Asn Arg Pro Leu Leu Lys Gln Gln 
145                 150                 155                 


<210>  3
<211>  1116
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1116)
<223>  thymic stromal lymphopoietin protein receptor (TSLPR)

<220>
<221>  CDS
<222>  (1)..(1116)

<400>  3
atg ggg cgg ctg gtt ctg ctg tgg gga gct gcc gtc ttt ctg ctg gga       48
Met Gly Arg Leu Val Leu Leu Trp Gly Ala Ala Val Phe Leu Leu Gly         
1               5                   10                  15              

ggc tgg atg gct ttg ggg caa gga gga gca gca gaa gga gta cag att       96
Gly Trp Met Ala Leu Gly Gln Gly Gly Ala Ala Glu Gly Val Gln Ile         
            20                  25                  30                  

cag atc atc tac ttc aat tta gaa acc gtg cag gtg aca tgg aat gcc      144
Gln Ile Ile Tyr Phe Asn Leu Glu Thr Val Gln Val Thr Trp Asn Ala         
        35                  40                  45                      

agc aaa tac tcc agg acc aac ctg act ttc cac tac aga ttc aac ggt      192
Ser Lys Tyr Ser Arg Thr Asn Leu Thr Phe His Tyr Arg Phe Asn Gly         
    50                  55                  60                          

gat gag gcc tat gac cag tgc acc aac tac ctt ctc cag gaa ggt cac      240
Asp Glu Ala Tyr Asp Gln Cys Thr Asn Tyr Leu Leu Gln Glu Gly His         
65                  70                  75                  80          

act tcg ggg tgc ctc cta gac gca gag cag cga gac gac att ctc tat      288
Thr Ser Gly Cys Leu Leu Asp Ala Glu Gln Arg Asp Asp Ile Leu Tyr         
                85                  90                  95              

ttc tcc atc agg aat ggg acg cac ccc gtt ttc acc gca agt cgc tgg      336
Phe Ser Ile Arg Asn Gly Thr His Pro Val Phe Thr Ala Ser Arg Trp         
            100                 105                 110                 

atg gtt tat tac ctg aaa ccc agt tcc ccg aag cac gtg aga ttt tcg      384
Met Val Tyr Tyr Leu Lys Pro Ser Ser Pro Lys His Val Arg Phe Ser         
        115                 120                 125                     

tgg cat cag gat gca gtg acg gtg acg tgt tct gac ctg tcc tac ggg      432
Trp His Gln Asp Ala Val Thr Val Thr Cys Ser Asp Leu Ser Tyr Gly         
    130                 135                 140                         

gat ctc ctc tat gag gtt cag tac cgg agc ccc ttc gac acc gag tgg      480
Asp Leu Leu Tyr Glu Val Gln Tyr Arg Ser Pro Phe Asp Thr Glu Trp         
145                 150                 155                 160         

cag tcc aaa cag gaa aat acc tgc aac gtc acc ata gaa ggc ttg gat      528
Gln Ser Lys Gln Glu Asn Thr Cys Asn Val Thr Ile Glu Gly Leu Asp         
                165                 170                 175             

gcc gag aag tgt tac tct ttc tgg gtc agg gtg aag gct atg gag gat      576
Ala Glu Lys Cys Tyr Ser Phe Trp Val Arg Val Lys Ala Met Glu Asp         
            180                 185                 190                 

gta tat ggg cca gac aca tac cca agc gac tgg tca gag gtg aca tgc      624
Val Tyr Gly Pro Asp Thr Tyr Pro Ser Asp Trp Ser Glu Val Thr Cys         
        195                 200                 205                     

tgg cag aga ggc gag att cgg gac gcc tgt gca gag aca cca acg cct      672
Trp Gln Arg Gly Glu Ile Arg Asp Ala Cys Ala Glu Thr Pro Thr Pro         
    210                 215                 220                         

ccc aaa cca aag ctg tcc aaa ttt att tta att tcc agc ctg gcc atc      720
Pro Lys Pro Lys Leu Ser Lys Phe Ile Leu Ile Ser Ser Leu Ala Ile         
225                 230                 235                 240         

ctt ctg atg gtg tct ctc ctc ctt ctg tct tta tgg aaa tta tgg aga      768
Leu Leu Met Val Ser Leu Leu Leu Leu Ser Leu Trp Lys Leu Trp Arg         
                245                 250                 255             

gtg aag aag ttt ctc att ccc agc gtg cca gac ccg aaa tcc atc ttc      816
Val Lys Lys Phe Leu Ile Pro Ser Val Pro Asp Pro Lys Ser Ile Phe         
            260                 265                 270                 

ccc ggg ctc ttt gag ata cac caa ggg aac ttc cag gag tgg atc aca      864
Pro Gly Leu Phe Glu Ile His Gln Gly Asn Phe Gln Glu Trp Ile Thr         
        275                 280                 285                     

gac acc cag aac gtg gcc cac ctc cac aag atg gca ggt gca gag caa      912
Asp Thr Gln Asn Val Ala His Leu His Lys Met Ala Gly Ala Glu Gln         
    290                 295                 300                         

gaa agt ggc ccc gag gag ccc ctg gta gtc cag ttg gcc aag act gaa      960
Glu Ser Gly Pro Glu Glu Pro Leu Val Val Gln Leu Ala Lys Thr Glu         
305                 310                 315                 320         

gcc gag tct ccc agg atg ctg gac cca cag acc gag gag aaa gag gcc     1008
Ala Glu Ser Pro Arg Met Leu Asp Pro Gln Thr Glu Glu Lys Glu Ala         
                325                 330                 335             

tct ggg gga tcc ctc cag ctt ccc cac cag ccc ctc caa ggc ggt gat     1056
Ser Gly Gly Ser Leu Gln Leu Pro His Gln Pro Leu Gln Gly Gly Asp         
            340                 345                 350                 

gtg gtc aca atc ggg ggc ttc acc ttt gtg atg aat gac cgc tcc tac     1104
Val Val Thr Ile Gly Gly Phe Thr Phe Val Met Asn Asp Arg Ser Tyr         
        355                 360                 365                     

gtg gcg ttg tga                                                     1116
Val Ala Leu                                                             
    370                                                                 


<210>  4
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Arg Leu Val Leu Leu Trp Gly Ala Ala Val Phe Leu Leu Gly 
1               5                   10                  15      


Gly Trp Met Ala Leu Gly Gln Gly Gly Ala Ala Glu Gly Val Gln Ile 
            20                  25                  30          


Gln Ile Ile Tyr Phe Asn Leu Glu Thr Val Gln Val Thr Trp Asn Ala 
        35                  40                  45              


Ser Lys Tyr Ser Arg Thr Asn Leu Thr Phe His Tyr Arg Phe Asn Gly 
    50                  55                  60                  


Asp Glu Ala Tyr Asp Gln Cys Thr Asn Tyr Leu Leu Gln Glu Gly His 
65                  70                  75                  80  


Thr Ser Gly Cys Leu Leu Asp Ala Glu Gln Arg Asp Asp Ile Leu Tyr 
                85                  90                  95      


Phe Ser Ile Arg Asn Gly Thr His Pro Val Phe Thr Ala Ser Arg Trp 
            100                 105                 110         


Met Val Tyr Tyr Leu Lys Pro Ser Ser Pro Lys His Val Arg Phe Ser 
        115                 120                 125             


Trp His Gln Asp Ala Val Thr Val Thr Cys Ser Asp Leu Ser Tyr Gly 
    130                 135                 140                 


Asp Leu Leu Tyr Glu Val Gln Tyr Arg Ser Pro Phe Asp Thr Glu Trp 
145                 150                 155                 160 


Gln Ser Lys Gln Glu Asn Thr Cys Asn Val Thr Ile Glu Gly Leu Asp 
                165                 170                 175     


Ala Glu Lys Cys Tyr Ser Phe Trp Val Arg Val Lys Ala Met Glu Asp 
            180                 185                 190         


Val Tyr Gly Pro Asp Thr Tyr Pro Ser Asp Trp Ser Glu Val Thr Cys 
        195                 200                 205             


Trp Gln Arg Gly Glu Ile Arg Asp Ala Cys Ala Glu Thr Pro Thr Pro 
    210                 215                 220                 


Pro Lys Pro Lys Leu Ser Lys Phe Ile Leu Ile Ser Ser Leu Ala Ile 
225                 230                 235                 240 


Leu Leu Met Val Ser Leu Leu Leu Leu Ser Leu Trp Lys Leu Trp Arg 
                245                 250                 255     


Val Lys Lys Phe Leu Ile Pro Ser Val Pro Asp Pro Lys Ser Ile Phe 
            260                 265                 270         


Pro Gly Leu Phe Glu Ile His Gln Gly Asn Phe Gln Glu Trp Ile Thr 
        275                 280                 285             


Asp Thr Gln Asn Val Ala His Leu His Lys Met Ala Gly Ala Glu Gln 
    290                 295                 300                 


Glu Ser Gly Pro Glu Glu Pro Leu Val Val Gln Leu Ala Lys Thr Glu 
305                 310                 315                 320 


Ala Glu Ser Pro Arg Met Leu Asp Pro Gln Thr Glu Glu Lys Glu Ala 
                325                 330                 335     


Ser Gly Gly Ser Leu Gln Leu Pro His Gln Pro Leu Gln Gly Gly Asp 
            340                 345                 350         


Val Val Thr Ile Gly Gly Phe Thr Phe Val Met Asn Asp Arg Ser Tyr 
        355                 360                 365             


Val Ala Leu 
    370     


<210>  5
<211>  459
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  MISC_FEATURE
<222>  (21)..(459)
<223>  Interleukin-7 receptor subunit alpha

<220>
<221>  MISC_FEATURE
<222>  (21)..(239)
<223>  extracellular domain

<400>  5

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Val Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


