                         SEQUENCE LISTING

<110>  ProtAffin Biotechnologie AG
 
<120>  Novel Glycosaminoglycan-antagonising MCP-1 mutants and methods of
        using same

<130>  PA007P

<160>  7     

<170>  PatentIn version 3.3

<210>  1
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Pro Asp Ala Ile Asn Ala Pro Val Thr Cys Cys Tyr Asn Phe Thr 
1               5                   10                  15      


Asn Arg Lys Ile Ser Val Gln Arg Leu Ala Ser Tyr Arg Arg Ile Thr 
            20                  25                  30          


Ser Ser Lys Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Ile Val Ala 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Lys Gln Lys Trp Val Gln Asp Ser Met 
    50                  55                  60                  


Asp His Leu Asp Lys Gln Thr Gln Thr Pro Lys Thr 
65                  70                  75      


<210>  2
<211>  76
<212>  PRT
<213>  artificial

<220>
<223>  MCP1 mutant M1

<400>  2

Gln Pro Asp Ala Ile Asn Ala Pro Val Thr Cys Cys Tyr Asn Phe Thr 
1               5                   10                  15      


Lys Arg Lys Ile Lys Val Gln Arg Leu Ala Ser Tyr Arg Arg Ile Thr 
            20                  25                  30          


Ser Ser Lys Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Ile Val Ala 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Lys Gln Lys Trp Val Gln Asp Ser Met 
    50                  55                  60                  


Asp His Leu Asp Lys Gln Thr Gln Thr Pro Lys Thr 
65                  70                  75      


<210>  3
<211>  76
<212>  PRT
<213>  artificial

<220>
<223>  MCP1 mutant M2

<400>  3

Gln Pro Asp Ala Ile Asn Ala Pro Val Thr Cys Cys Tyr Asn Phe Thr 
1               5                   10                  15      


Lys Arg Lys Ile Ser Val Lys Arg Leu Ala Ser Tyr Arg Arg Ile Thr 
            20                  25                  30          


Ser Ser Lys Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Ile Val Ala 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Lys Gln Lys Trp Val Gln Asp Ser Met 
    50                  55                  60                  


Asp His Leu Asp Lys Gln Thr Gln Thr Pro Lys Thr 
65                  70                  75      


<210>  4
<211>  76
<212>  PRT
<213>  artificial

<220>
<223>  MCP1 mutant M3

<400>  4

Gln Pro Asp Ala Ile Asn Ala Pro Val Thr Cys Cys Tyr Asn Phe Thr 
1               5                   10                  15      


Lys Arg Lys Ile Ser Val Gln Arg Leu Ala Ser Tyr Arg Arg Ile Thr 
            20                  25                  30          


Ser Ser Lys Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Ile Lys Ala 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Lys Gln Lys Trp Val Gln Asp Ser Met 
    50                  55                  60                  


Asp His Leu Asp Lys Gln Thr Gln Thr Pro Lys Thr 
65                  70                  75      


<210>  5
<211>  76
<212>  PRT
<213>  artificial

<220>
<223>  MCP1 mutant M4

<400>  5

Gln Pro Asp Ala Ile Asn Ala Pro Val Thr Cys Cys Tyr Asn Phe Thr 
1               5                   10                  15      


Lys Arg Lys Ile Ser Val Gln Arg Leu Ala Ser Tyr Arg Arg Ile Thr 
            20                  25                  30          


Ser Lys Lys Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Ile Lys Ala 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Lys Gln Lys Trp Val Gln Asp Ser Met 
    50                  55                  60                  


Asp His Leu Asp Lys Gln Thr Gln Thr Pro Lys Thr 
65                  70                  75      


<210>  6
<211>  76
<212>  PRT
<213>  artificial

<220>
<223>  MCP1 mutant M5

<400>  6

Gln Pro Asp Ala Ile Asn Ala Pro Val Thr Cys Cys Tyr Asn Phe Thr 
1               5                   10                  15      


Lys Arg Lys Ile Lys Val Gln Arg Leu Ala Ser Tyr Arg Arg Ile Thr 
            20                  25                  30          


Ser Lys Lys Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Ile Lys Ala 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Lys Gln Lys Trp Val Gln Asp Ser Met 
    50                  55                  60                  


Asp His Leu Asp Lys Gln Thr Gln Thr Pro Lys Thr 
65                  70                  75      


<210>  7
<211>  77
<212>  PRT
<213>  artificial

<220>
<223>  MCP1 mutant protein formula


<220>
<221>  M
<222>  (1)..(1)
<223>  M = methionine or no amino acid residue

<220>
<221>  PDAINAZ
<222>  (3)..(9)
<223>  PDAINAZ =  PDAINAZ or no amino acid residue

<220>
<221>  Z
<222>  (9)..(9)
<223>  Z = proline or alanine or glycine or leucine, preferably it is 
       alanine

<220>
<221>  X
<222>  (14)..(14)
<223>  X = tyrosine and/or alanine, preferably it is alanine

<220>
<221>  X
<222>  (18)..(18)
<223>  X = arginine or lysine or histidine or asparagine or glutamine,  
       preferably it is lysine

<220>
<221>  Z
<222>  (19)..(19)
<223>  Z = arginine or lysine

<220>
<221>  Z
<222>  (20)..(20)
<223>  Z = lysine or arginine

<220>
<221>  X
<222>  (22)..(22)
<223>  X = serine or lysine or histidine or asparagine or arginine 
       and/or glutamine, preferably it is arginine

<220>
<221>  X
<222>  (24)..(24)
<223>  X = arginine or lysine or histidine or asparagine and/or 
       glutamine, preferably it is arginine

<220>
<221>  X
<222>  (35)..(35)
<223>  X = serine or lysine or histidine or asparagine and/or glutamine,
       preferably it is arginine

<220>
<221>  X
<222>  (48)..(48)
<223>  X = valine or arginine or lysine or histidine or asparagine 
       and/or glutamine, preferably it is lysine

<400>  7

Met Gln Pro Asp Ala Ile Asn Ala Glx Val Thr Cys Cys Xaa Asn Phe 
1               5                   10                  15      


Thr Xaa Glx Glx Ile Xaa Val Xaa Arg Leu Ala Ser Tyr Arg Arg Ile 
            20                  25                  30          


Thr Ser Xaa Lys Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Ile Xaa 
        35                  40                  45              


Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln Lys Trp Val Gln Asp Ser 
    50                  55                  60                  


Met Asp His Leu Asp Lys Gln Thr Gln Thr Pro Lys Thr 
65                  70                  75          


