                         SEQUENCE LISTING

<110>  Epimmune, Inc.
 
<120>  PAN-DR BINDING POLYPEPTIDES AND USES THEREOF

<130>  17622PCT00

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Trp, Phe, Tyr, His, Asp, Glu, Asn, Gln, Ile, or Lys

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be Phe, Asn, Tyr or Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa can be His or Lys

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be Ala, Asp or Glu

<400>  1

Ala Xaa Phe Val Ala Ala Xaa Thr Leu Xaa Ala Xaa Ala 
1               5                   10              


<210>  2
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Tyr, His, Ile, Glu, Asn, Gln and Lys

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be Phe, Asn, Tyr or Trp

<400>  2

Ala Xaa Phe Val Ala Ala Xaa Thr Leu His Ala Ala Ala 
1               5                   10              


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  3

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10              


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  4

Ala Ala Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  5

Ala Ala Ala Trp Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  6

Ala Ala Ala Lys Phe Val Ala Ala Trp Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  7

Ala Ala Ala Trp Phe Val Ala Ala Trp Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  8

Ala Ala Ala Trp Phe Val Ala Ala Tyr Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  9

Ala Ala Ala Trp Phe Val Ala Ala Phe Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  10

Ala Ala Ala Trp Phe Val Ala Ala Asn Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  11

Ala Ala Ala Phe Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  12

Ala Ala Ala Phe Phe Val Ala Ala Trp Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  13

Ala Ala Ala Phe Phe Val Ala Ala Tyr Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  14

Ala Ala Ala Phe Phe Val Ala Ala Phe Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  15

Ala Ala Ala Phe Phe Val Ala Ala Asn Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  16

Ala Ala Ala Phe Phe Val Ala Ala Trp Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  17

Ala Ala Ala Phe Phe Val Ala Ala Tyr Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  18

Ala Ala Ala Phe Phe Val Ala Ala Phe Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  19

Ala Ala Ala Phe Phe Val Ala Ala Asn Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  20

Ala Ala Ala Tyr Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  21

Ala Ala Ala Tyr Phe Val Ala Ala Trp Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  22

Ala Ala Ala Tyr Phe Val Ala Ala Tyr Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  23

Ala Ala Ala Tyr Phe Val Ala Ala Phe Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  24

Ala Ala Ala Tyr Phe Val Ala Ala Asn Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  25

Ala Ala Ala His Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  26

Ala Ala Ala His Phe Val Ala Ala Trp Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  27

Ala Ala Ala His Phe Val Ala Ala Tyr Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  28

Ala Ala Ala His Phe Val Ala Ala Phe Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  29

Ala Ala Ala His Phe Val Ala Ala Asn Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  30

Ala Ala Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  31

Ala Ala Ala His Phe Val Ala Ala Trp Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  32

Ala Ala Ala His Phe Val Ala Ala Tyr Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  33

Ala Ala Ala His Phe Val Ala Ala Phe Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  34

Ala Ala Ala His Phe Val Ala Ala Asn Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  35

Ala Ala Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Glu Ala 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  36

Ala Ala Ala His Phe Val Ala Ala Trp Thr Leu Lys Ala Glu Ala 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  37

Ala Ala Ala His Phe Val Ala Ala Tyr Thr Leu Lys Ala Glu Ala 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  38

Ala Ala Ala His Phe Val Ala Ala Phe Thr Leu Lys Ala Glu Ala 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  39

Ala Ala Ala His Phe Val Ala Ala Asn Thr Leu Lys Ala Glu Ala 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  40

Ala Ala Ala Asp Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  41

Ala Ala Ala Asp Phe Val Ala Ala Trp Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  42

Ala Ala Ala Asp Phe Val Ala Ala Tyr Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  43

Ala Ala Ala Asp Phe Val Ala Ala Phe Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  44

Ala Ala Ala Asp Phe Val Ala Ala Asn Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  45

Ala Ala Ala Glu Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  46

Ala Ala Ala Glu Phe Val Ala Ala Trp Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  47

Ala Ala Ala Glu Phe Val Ala Ala Tyr Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  48

Ala Ala Ala Glu Phe Val Ala Ala Phe Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  49

Ala Ala Ala Glu Phe Val Ala Ala Asn Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  50

Ala Ala Ala Asn Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  51

Ala Ala Ala Asn Phe Val Ala Ala Trp Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  52

Ala Ala Ala Asn Phe Val Ala Ala Tyr Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  53

Ala Ala Ala Asn Phe Val Ala Ala Phe Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  54

Ala Ala Ala Asn Phe Val Ala Ala Asn Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  55

Ala Ala Ala Asn Phe Val Ala Ala Trp Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  56

Ala Ala Ala Asn Phe Val Ala Ala Tyr Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  57
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  57

Ala Ala Ala Asn Phe Val Ala Ala Phe Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  58

Ala Ala Ala Asn Phe Val Ala Ala Asn Thr Leu Lys Ala Asp Ala 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  59

Ala Ala Ala Asn Phe Val Ala Ala Trp Thr Leu Lys Ala Glu Ala 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  60

Ala Ala Ala Asn Phe Val Ala Ala Tyr Thr Leu Lys Ala Glu Ala 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  61

Ala Ala Ala Asn Phe Val Ala Ala Phe Thr Leu Lys Ala Glu Ala 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  62

Ala Ala Ala Asn Phe Val Ala Ala Asn Thr Leu Lys Ala Glu Ala 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  63

Ala Ala Ala Gln Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10                  15  


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  64

Ala Ala Ala Gln Phe Val Ala Ala Trp Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  65

Ala Ala Ala Gln Phe Val Ala Ala Tyr Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  66

Ala Ala Ala Gln Phe Val Ala Ala Phe Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  67

Ala Ala Ala Gln Phe Val Ala Ala Asn Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  68

Ala Ala Ala Ile Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  69

Ala Ala Ala Ile Phe Val Ala Ala Trp Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  70

Ala Ala Ala Ile Phe Val Ala Ala Tyr Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  71

Ala Ala Ala Ile Phe Val Ala Ala Phe Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pan-DR binding peptide

<400>  72

Ala Ala Ala Ile Phe Val Ala Ala Asn Thr Leu His Ala Ala Ala 
1               5                   10                  15  


<210>  73
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TNF variant

<400>  73

Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
        35                  40                  45              


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
    130                 135                 140                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155         


<210>  74
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TNF variant

<400>  74

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Ser Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala 
            100                 105                 110         


Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu 
        115                 120                 125             


Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp 
    130                 135                 140                 


Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155             


<210>  75
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TNF variant incorporating pan-DR binding peptide

<400>  75

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Ser Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Lys Phe 
            100                 105                 110         


Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Glu Ala Lys Pro Trp Tyr 
        115                 120                 125             


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
    130                 135                 140                 


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
145                 150                 155                 160 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
                165                 170 


<210>  76
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TNF variant incorporating pan-DR binding peptide

<400>  76

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Ser Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Trp Phe 
            100                 105                 110         


Val Ala Ala Asn Thr Leu His Ala Ala Ala Glu Ala Lys Pro Trp Tyr 
        115                 120                 125             


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
    130                 135                 140                 


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
145                 150                 155                 160 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
                165                 170 


<210>  77
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TNF variant incorporating pan-DR binding peptide

<400>  77

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Ser Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Phe Phe 
            100                 105                 110         


Val Ala Ala Asn Thr Leu Lys Ala Asp Ala Glu Ala Lys Pro Trp Tyr 
        115                 120                 125             


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
    130                 135                 140                 


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
145                 150                 155                 160 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
                165                 170 


<210>  78
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TNF variant incorporating pan-DR binding peptide

<400>  78

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Ser Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Tyr Phe 
            100                 105                 110         


Val Ala Ala Phe Thr Leu His Ala Ala Ala Glu Ala Lys Pro Trp Tyr 
        115                 120                 125             


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
    130                 135                 140                 


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
145                 150                 155                 160 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
                165                 170 


<210>  79
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TNF variant incorporating pan-DR binding peptide

<400>  79

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Ser Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala His Phe 
            100                 105                 110         


Val Ala Ala Asn Thr Leu His Ala Ala Ala Glu Ala Lys Pro Trp Tyr 
        115                 120                 125             


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
    130                 135                 140                 


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
145                 150                 155                 160 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
                165                 170 


<210>  80
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TNF variant incorporating pan-DR binding peptide

<400>  80

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Ser Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala His Phe 
            100                 105                 110         


Val Ala Ala Phe Thr Leu Lys Ala Glu Ala Glu Ala Lys Pro Trp Tyr 
        115                 120                 125             


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
    130                 135                 140                 


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
145                 150                 155                 160 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
                165                 170 


<210>  81
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TNF variant incorporating pan-DR binding peptide

<400>  81

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Ser Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Phe 
            100                 105                 110         


Val Ala Ala Trp Thr Leu His Ala Ala Ala Glu Ala Lys Pro Trp Tyr 
        115                 120                 125             


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
    130                 135                 140                 


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
145                 150                 155                 160 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
                165                 170 


<210>  82
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TNF variant incorporating pan-DR binding peptide

<400>  82

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Ser Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Asn Phe 
            100                 105                 110         


Val Ala Ala Tyr Thr Leu His Ala Ala Ala Glu Ala Lys Pro Trp Tyr 
        115                 120                 125             


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
    130                 135                 140                 


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
145                 150                 155                 160 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
                165                 170 


<210>  83
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TNF variant incorporating pan-DR binding peptide

<400>  83

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Ser Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Gln Phe 
            100                 105                 110         


Val Ala Ala Asn Thr Leu His Ala Ala Ala Glu Ala Lys Pro Trp Tyr 
        115                 120                 125             


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
    130                 135                 140                 


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
145                 150                 155                 160 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
                165                 170 


<210>  84
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TNF variant incorporating pan-DR binding peptide

<400>  84

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Ser Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Ile Phe 
            100                 105                 110         


Val Ala Ala Trp Thr Leu His Ala Ala Ala Glu Ala Lys Pro Trp Tyr 
        115                 120                 125             


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
    130                 135                 140                 


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
145                 150                 155                 160 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
                165                 170 


