                         SEQUENCE LISTING

<110>  MONOCLONAL ANTIBODIES THERAPEUTICS MATBIOPHARMA
       Institut National de la Sant et de la Recherche Mdicale (INSERM)
       DIDIERLAURENT Denis
       CHOSE Olivier
       KADOUCHE Jean
 
<120>  NEW ANTI-CD160 MONOCLONAL ANTIBODIES AND USES THEREOF

<130>  D25265

<150>  EP09305057.3
<151>  2009-01-21

<160>  29    

<170>  PatentIn version 3.3

<210>  1
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 from light chain of anti-CD160 antibody

<400>  1

Gln Ser Ile Ser Asn His 
1               5       


<210>  2
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 from light chain of anti-CD160 antibody

<400>  2

Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   


<210>  3
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 from heavy chain of anti-CD160 antibody

<400>  3

Gly Tyr Thr Phe Thr Asp Tyr Trp 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 from heavy chain of anti-CD160 antibody

<400>  4

Ile Tyr Pro Gly Asp Asp Asp Ala 
1               5               


<210>  5
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 from heavy chain of anti-CD160 antibody

<400>  5

Ala Arg Arg Gly Ile Ala Ala Val Val Gly Gly Phe Asp Tyr 
1               5                   10                  


<210>  6
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Val His Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          

Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              

Gly Ser Ile Tyr Pro Gly Asp Asp Asp Ala Arg Tyr Thr Gln Lys Phe 
    50                  55                  60                  

Arg Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Gly Ile Ala Ala Val Val Gly Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  7
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  7
caggttcacc tccagcagtc tggggctgag ctggcaagac ctggggcttc agtgaagttg     60

tcctgcaagg cttctggcta cacctttact gactactgga tgcagtggat aaaacagagg    120

cctggacagg gtctggaatg gattgggtct atttatcctg gagatgatga tgctaggtac    180

actcagaagt tcaggggcaa ggccacattg actgcagata aatcctccag cacagcctac    240

atgcagctca gcagcttggc atctgaagac tctgcggtct attactgtgc aagaaggggt    300

attgctgcgg tagtaggcgg ctttgactac tggggccaag gcaccactct cacagtctcc    360

tca                                                                  363


<210>  8
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  8

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      

Asn Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn His 
            20                  25                  30          

Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              

Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  

Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      

Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  9
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  9
gatattgtgc taactcagtc tccagccacc ctgtctgtga ctccaggaaa tagcgtcagt     60

ctttcctgca gggccagcca aagtattagc aaccacctac actggtatca acaaaaatca    120

catgagtctc caaggcttct catcaagtat gcttcccagt ccatctctgg gatcccctcc    180

aggttcagtg gcagtggatc agggacagat ttcactctca gtatcaacag tgtggagact    240

gaagattttg gcatgtattt ctgtcaacag agtaacagct ggccgctcac gttcggtgct    300

gggaccaagc tggagctaaa acgg                                           324


<210>  10
<211>  114
<212>  PRT
<213>  homo sapiens

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Cys 
        


<210>  11
<211>  345
<212>  DNA
<213>  homo sapiens

<400>  11
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccat gctaa                    345


<210>  12
<211>  330
<212>  PRT
<213>  homo sapiens

<400>  12

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 

Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 

Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  13
<211>  993
<212>  DNA
<213>  homo sapiens

<400>  13
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag    720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa taa                                 993


<210>  14
<211>  327
<212>  PRT
<213>  homo sapiens

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  

Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         

Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 

Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             

Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 

Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             

Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 

Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  15
<211>  984
<212>  DNA
<213>  homo sapiens

<400>  15
gctagcacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag     60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc    240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc    300

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc    360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg    420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat    480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac    540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag    600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa    660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag    720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag    780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc    840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg    900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc    960

ctctccctgt ctctgggtaa ataa                                           984


<210>  16
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  16

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  17
<211>  324
<212>  DNA
<213>  homo sapiens

<400>  17
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct     60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag    120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac    180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag    240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagttcgcc cgtcacaaag    300

agcttcaaca ggggagagtg ttaa                                           324


<210>  18
<211>  130
<212>  PRT
<213>  mus musculus

<400>  18

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      

Leu Pro Gly Ala Arg Cys Asp Ile Val Leu Thr Gln Ser Pro Ala Thr 
            20                  25                  30          

Leu Ser Val Thr Pro Gly Asn Ser Val Ser Leu Ser Cys Arg Ala Ser 
        35                  40                  45              

Gln Ser Ile Ser Asn His Leu His Trp Tyr Gln Gln Lys Ser His Glu 
    50                  55                  60                  

Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile 
65                  70                  75                  80  

Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser 
                85                  90                  95      

Ile Asn Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln 
            100                 105                 110         

Ser Asn Ser Trp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             

Lys Arg 
    130 


<210>  19
<211>  390
<212>  DNA
<213>  mus musculus

<400>  19
atggacatgc gtgtgcccgc tcaactcctg ggcctgctgc tgctctggct cccaggtgcg     60

cgctgtgata ttgtgctaac tcagtctcca gccaccctgt ctgtgactcc aggaaatagc    120

gtcagtcttt cctgcagggc cagccaaagt attagcaacc acctacactg gtatcaacaa    180

aaatcacatg agtctccaag gcttctcatc aagtatgctt cccagtccat ctctgggatc    240

ccctccaggt tcagtggcag tggatcaggg acagatttca ctctcagtat caacagtgtg    300

gagactgaag attttggcat gtatttctgt caacagagta acagctggcc gctcacgttc    360

ggtgctggga ccaagctgga gctaaaacgg                                     390


<210>  20
<211>  140
<212>  PRT
<213>  mus musculus

<400>  20

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      

Val Gln Cys Gln Val His Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
            20                  25                  30          

Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              

Thr Asp Tyr Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  

Glu Trp Ile Gly Ser Ile Tyr Pro Gly Asp Asp Asp Ala Arg Tyr Thr 
65                  70                  75                  80  

Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      

Thr Ala Tyr Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val 
            100                 105                 110         

Tyr Tyr Cys Ala Arg Arg Gly Ile Ala Ala Val Val Gly Gly Phe Asp 
        115                 120                 125             

Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140 


<210>  21
<211>  420
<212>  DNA
<213>  mus musculus

<400>  21
atggagttcg gcctgagctg gctgttcctg gtggctattc ttaagggtgt ccagtgtcag     60

gttcacctcc agcagtctgg ggctgagctg gcaagacctg gggcttcagt gaagttgtcc    120

tgcaaggctt ctggctacac ctttactgac tactggatgc agtggataaa acagaggcct    180

ggacagggtc tggaatggat tgggtctatt tatcctggag atgatgatgc taggtacact    240

cagaagttca ggggcaaggc cacattgact gcagataaat cctccagcac agcctacatg    300

cagctcagca gcttggcatc tgaagactct gcggtctatt actgtgcaag aaggggtatt    360

gctgcggtag taggcggctt tgactactgg ggccaaggca ccactctcac agtctcctca    420


<210>  22
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Asn Tyr 
            20                  25                  30          

Leu Ala Trp Tyr Gln Gln Lys Asp Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              

Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Thr Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Asn Trp Pro Leu 
                85                  90                  95      

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  23
<211>  114
<212>  PRT
<213>  homo sapiens

<400>  23

Gln Val Gln Leu Leu Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          

Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              

Gly Met Ile Asp Pro Asn Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  

Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Asn Thr Ala Tyr 
65                  70                  75                  80  

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      

Thr Arg Arg Asp Met Asp Tyr Trp Gly Ala Gly Thr Thr Val Thr Val 
            100                 105                 110         

Ser Ser 
        


<210>  24
<211>  114
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Glu Val Xaa Leu Gln Glx Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      

Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          

Trp Leu His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              

Gly Gly Ile Tyr Pro Gly Asn Arg Asp Thr Arg Tyr Thr Gln Arg Phe 
    50                  55                  60                  

Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ser Ile Ile Tyr Phe Asp Tyr Ala Asp Phe Ile Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly 
        


<210>  25
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  humanized variable light chain anti-CD160 antibody

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  X= N or E

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  X= S or R

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  X= V or A

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  X= H or G

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  X= Q or N

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  X= T or P

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  X= G or A

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  X= G or A

<400>  25

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      

Xaa Xaa Xaa Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn His 
            20                  25                  30          

Leu His Trp Tyr Gln Gln Lys Ser Xaa Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              

Lys Tyr Ala Ser Xaa Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Xaa 
65                  70                  75                  80  

Glu Asp Phe Xaa Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      

Thr Phe Gly Xaa Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  26
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>   humanized variable heavy chain anti-CD160 antibody


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X= H or Q

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  X= H or Q

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  X= A or T

<400>  26

Gln Val Xaa Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          

Trp Met Xaa Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              

Gly Ser Ile Tyr Pro Gly Asp Asp Asp Ala Arg Tyr Thr Gln Lys Phe 
    50                  55                  60                  

Arg Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Gln Leu Ser Ser Leu Xaa Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Gly Ile Ala Ala Val Val Gly Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  27
<211>  181
<212>  PRT
<213>  homo sapiens

<400>  27

Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      

Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser 
            20                  25                  30          

Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His 
        35                  40                  45              

Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  

Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  

Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      

Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys 
            100                 105                 110         

Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             

Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys 
    130                 135                 140                 

Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser 
145                 150                 155                 160 

Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val 
                165                 170                 175     

Ala Leu Gln Ala Leu 
            180     


<210>  28
<211>  129
<212>  PRT
<213>  Mus musculus

<400>  28

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      

Leu Pro Gly Ala Arg Cys Asp Ile Val Leu Thr Gln Ser Pro Ala Thr 
            20                  25                  30          

Leu Ser Val Thr Pro Gly Asn Ser Val Ser Leu Ser Cys Arg Ala Ser 
        35                  40                  45              

Gln Ser Ile Ser Asn His Leu His Trp Tyr Gln Gln Lys Ser His Glu 
    50                  55                  60                  

Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile 
65                  70                  75                  80  

Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser 
                85                  90                  95      

Ile Asn Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln 
            100                 105                 110         

Ser Asn Ser Trp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             

Lys 
    


<210>  29
<211>  387
<212>  DNA
<213>  Mus musculus

<400>  29
atggacatgc gtgtgcccgc tcaactcctg ggcctgctgc tgctctggct cccaggtgcg     60

cgctgtgata ttgtgctaac tcagtctcca gccaccctgt ctgtgactcc aggaaatagc    120

gtcagtcttt cctgcagggc cagccaaagt attagcaacc acctacactg gtatcaacaa    180

aaatcacatg agtctccaag gcttctcatc aagtatgctt cccagtccat ctctgggatc    240

ccctccaggt tcagtggcag tggatcaggg acagatttca ctctcagtat caacagtgtg    300

gagactgaag attttggcat gtatttctgt caacagagta acagctggcc gctcacgttc    360

ggtgctggga ccaagctgga gctaaaa                                        387


