                         SEQUENCE LISTING

<110>  Bayer HealthCare LLC
       Tang, Liang
       Mei, Baisong
       Murphy, John E.
       Wang, Jun
 
<120>  PROTEIN CONJUGATE HAVING AN ENDOPEPTIDASE- CLEAVABLE 
       BIOPROTECTIVE MOIETY

<130>  MSB-7336

<150>  US 61/145,644
<151>  2009-01-19

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is a hydrophobic amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is an amino acid residue other than an acidic amino acid 
       residue.

<400>  1

Xaa Xaa Pro Arg Xaa Xaa 
1               5       


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  Xaa is a amino acid residue other than acidic amino acid residue.

<400>  2

Gly Arg Xaa Xaa 
1               


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is an amino acid residue other than Arg or Pro.

<400>  3

Ile Glu Gly Arg Xaa 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is an amino acid residue other than Arg or Pro.

<400>  4

Ile Asp Gly Arg Xaa 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is an amino acid residue other than Arg or Pro.

<400>  5

Ala Glu Gly Arg Xaa 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ile or Thr.

<400>  6

Ile Glu Gly Arg Xaa 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ile or Thr.

<400>  7

Ile Asp Gly Arg Xaa 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ile or Thr.

<400>  8

Ala Glu Gly Arg Xaa 
1               5   


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  9

Asp His His His His His His Gln Gly Arg Gly Leu Lys 
1               5                   10              


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  10

Gly Gly Gly Leu Val Pro Arg Gly Ser Gly Lys 
1               5                   10      


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  11

Gly Gly Gly Leu Thr Arg Ile Val Gly Leu Val Pro Arg Gly Ser Gly 
1               5                   10                  15      


Lys 
    


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  PEGylated with PEG4 unit

<400>  12

Gly Gly Gly Leu Thr Arg Ile Val Gly Leu Val Pro Arg Gly Ser Gly 
1               5                   10                  15      


Lys 
    


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  PEGylation with PEG12 unit.

<400>  13

Gly Gly Gly Leu Thr Arg Ile Val Gly Leu Val Pro Arg Gly Ser Gly 
1               5                   10                  15      


Lys 
    


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  PEGylation with PEG4 unit.

<400>  14

Xaa Thr Pro Arg Ser Asn Arg Gly Lys 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  PEGylation with PEG12 unit.

<400>  15

Xaa Thr Pro Arg Ser Asn Arg Gly Lys 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  PEGylation with PEG4 unit.

<400>  16

Leu Thr Pro Arg Arg Asn Arg Gly Lys 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  PEGylation with PEG12 unit.

<400>  17

Leu Thr Pro Arg Arg Asn Arg Gly Lys 
1               5                   


<210>  18
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  18

Gly Gly Gly Leu Thr Arg Ile Val Gly Leu Val Pro Arg Gly Ser Gly 
1               5                   10                  15      


Lys Gly Gly Gly Leu Thr Arg Ile Val Gly Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Lys 
        


