                         SEQUENCE LISTING

<110>  Codexis, Inc.
       de Vries, Erik
       Clark, Louis
       McVicar, Scott
       Segraves, Erika
       Song, Shiwei
       Tan, Kheng Lin
 
<120>  RECOMBINANT HALOHYDRIN DEHALOGENASE POLYPEPTIDES

<130>  CX2-027US1

<150>  61/138,943
<151>  2008-12-18

<160>  304   

<170>  PatentIn version 3.5

<210>  1
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  1
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgctcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagatatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgccctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgctatcga acgttggccc ggcatgcccg aataa                      765


<210>  2
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  2

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  3
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  3
atgagcaccg ctatcgtcac caacgtcaaa cattttggag gtatgggtag cgctctgagg       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaaaca gaaagatgaa      120

ctggaagctt ttgctgaaac ctacccacag ctgaaaccaa tgagcgaaca ggaaccagct      180

gaactgatcg aagctgtcac cagcgcttac ggtcaggtcg atgtcctggt cagcaacgat      240

atctttgctc cagaatttca gccaatcgat aaatacgctg tcgaagatta caggggtgct      300

gtcgaagctc tgcagatcag gccatttgct ctagtgaatg ctgtggcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggcta ctccgttcgg gccatggaag      420

gagctatcga cttacacttc ggctcgagct ggggcttcta ctctagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ggccgaatta cctacactcg      540

gaggattcgc cgtacttcta cccgactgag ccgtggaaga ctaatccgga gcacgtggct      600

cacgtgaaga aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtggcatttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccatgataga acgtttcccc ggcatgcccg aataa                      765


<210>  4
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  4

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Phe Pro Gly Met Pro Glu 
                245                 250                 


<210>  5
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  5
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgtcatccc ggcatgcccg aataa                      765


<210>  6
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  6

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg His Pro Gly Met Pro Glu 
                245                 250                 


<210>  7
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  7
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcagggtgaa      120

ctggaagctt ttgctgagac ctacccacag ctgataccaa tgagcgaaca ggaaccaact      180

gaactgattg aagctgtcac cggtgctctt ggtcaggtcg atgtcctggt cagcaacgat      240

atcgctcctg tggaatggcg gccaattgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccattttct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtggcatttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttgaca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  8
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  8

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Gly Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Thr Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Gly Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ser Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  9
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  9
atgagcaccg ctattgtcac caacgtccga cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctggaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccaact      180

gaactgattg aagctgttac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgctgctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aacgcgagtt gggggaattg      660

gtggcatttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcataga acgtcggccc ggcatgcccg aataa                      765


<210>  10
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  10

Met Ser Thr Ala Ile Val Thr Asn Val Arg His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Thr Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Arg Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Arg Pro Gly Met Pro Glu 
                245                 250                 


<210>  11
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  11
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttctg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatacccg aataa                      765


<210>  12
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  12

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Trp Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Ile Pro Glu 
                245                 250                 


<210>  13
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  13
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cgtacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt tttgttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  14
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  14

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Val His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Leu Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  15
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  15
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atatcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt tttgttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  16
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  16

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Leu Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  17
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  17
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat agatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta ccccactgag ccgtggaaga cttctctgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttgaca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  18
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  18

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Leu Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  19
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  19
atgagcacct ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat agatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta ccccactgag ccgtggaaga cttctctgga gcacgtggct      600

cacgtgcgca aggtgactgc tctacaacga ctagggactc aagaagagtt gggggaattg      660

gtaacctttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttgaca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  20
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  20

Met Ser Thr Ser Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Leu Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  21
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  21
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcaggtcg atgtcctggt cagcaacgat      240

atcgctcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctctcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgccctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttgaca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  22
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  22

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  23
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  23
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcgtgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatataag      420

gagttgtcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactacta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgtaggccc ggcatgcccg aataa                      765


<210>  24
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  24

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Tyr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Arg Pro Gly Met Pro Glu 
                245                 250                 


<210>  25
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  25
atgagcaccg ctattgtcac caacgtcaaa cattcgggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgttctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgtttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  26
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  26

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Ser Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Val Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Val Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  27
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  27
atgagcaccg ctattgtcac caacgtcaaa catgggggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  28
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  28

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Gly Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  29
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  29
atgagcaccg ctattgtcac caacgtcaaa catatgggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  30
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  30

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Met Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  31
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  31
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaattaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  32
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  32

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Ile Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  33
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  33
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccactgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  34
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  34

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Leu Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  35
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  35
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccagttaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  36
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  36

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Val Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  37
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  37
atgggcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggcgg ccccgttcgg gccaacgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  38
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  38

Met Gly Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  39
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  39
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaagtaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  40
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  40

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Ser Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  41
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  41
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaaataag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  42
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  42

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asn Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  43
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  43
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctatgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  44
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  44

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Met Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  45
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  45
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctctgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  46
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  46

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Leu Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  47
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  47
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctgtgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  48
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  48

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Val Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  49
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  49
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctggtaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  50
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  50

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Gly Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  51
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  51
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctattaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  52
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  52

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Ile Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  53
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  53
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggcta ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctctgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  54
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  54

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Leu Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  55
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  55
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctagtaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  56
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  56

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Ser Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  57
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  57
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg cttgtaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  58
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  58

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Cys Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  59
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  59
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctaataatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  60
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  60

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Asn Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  61
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  61
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggcta ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  62
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  62

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  63
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  63
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgcatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  64
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  64

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro His 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  65
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  65
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactggttg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgtttta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  66
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  66

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Phe 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  67
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  67
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgatgta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  68
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  68

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Met 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  69
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  69
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgcagta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  70
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  70

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Gln 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  71
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  71
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaattc gctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  72
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  72

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ser Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  73
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  73
atgagcaccg ctattgtcac caacgtcaat cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gttttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  74
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  74

Met Ser Thr Ala Ile Val Thr Asn Val Asn His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  75
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  75
atgagcaccg ctattgtcac caacgtcaga cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaataa tctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  76
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  76

Met Ser Thr Ala Ile Val Thr Asn Val Arg His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Asn Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  77
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  77
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatac tctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  78
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  78

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Thr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  79
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  79
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaattt gctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  80
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  80

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Leu Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  81
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  81
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcacgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  82
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  82

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Thr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  83
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  83
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaag gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  84
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  84

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Gly Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  85
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  85
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat cgtcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta ctgtcactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  86
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  86

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Val 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Cys His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  87
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  87
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cacgcactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  88
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  88

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Thr His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  89
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  89
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacca tatcccggtg ttcgccatcg ctccgaatta cgtgcactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  90
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  90

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr His Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Val His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  91
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  91
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatgg gccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  92
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  92

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Gly Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  93
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  93
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactattc gccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  94
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  94

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Ser Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  95
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  95
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatat tccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  96
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  96

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Ile Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  97
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  97
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatca cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  98
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  98

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr His Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  99
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  99
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaattaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgtgggccc ggcatgcccg aataa                      765


<210>  100
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  100

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Ile Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Gly Pro Gly Met Pro Glu 
                245                 250                 


<210>  101
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  101
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccattgaag      420

gagctatcga cttactcttc ggctcgagtt ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgtattccc ggcatgcccg aataa                      765


<210>  102
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  102

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Leu Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Val Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Ile Pro Gly Met Pro Glu 
                245                 250                 


<210>  103
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  103
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccacttaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgt                                             744


<210>  104
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  104

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Leu Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg 
                245             


<210>  105
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  105
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaccgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgtgctccc ggcatgcccg aataa                      765


<210>  106
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  106

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Pro Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Ala Pro Gly Met Pro Glu 
                245                 250                 


<210>  107
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  107
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaggtaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgtagtccc ggcatgcccg aataa                      765


<210>  108
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  108

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Gly Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Ser Pro Gly Met Pro Glu 
                245                 250                 


<210>  109
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  109
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtaccatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  110
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  110

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr His Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  111
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  111
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

gggagttcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  112
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  112

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Ser Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  113
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  113
atgagcaccg ctattgtcac caacgtcaaa cattacggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  114
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  114

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Tyr Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  115
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  115
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgagtg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaacgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcctgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  116
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  116

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Ser Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  117
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  117
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgactta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgcttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggtttgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  118
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  118

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Thr 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Leu Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Leu Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  119
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  119
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggcttgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  120
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  120

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Leu Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  121
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  121
atgagcaccg ctattgtcac caacgtcaaa cattttgggg gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  122
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  122

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  123
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  123
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggcttgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  124
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  124

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Leu Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  125
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  125
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaacgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggcttgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  126
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  126

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Leu Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  127
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  127
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatcgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cattagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccggatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  128
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  128

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Ser Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asp 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  129
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  129
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggtatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cgggacacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  130
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  130

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Val Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  131
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  131
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta caggaatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  132
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  132

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asn Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  133
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  133
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc gcttcggctg ccccgttcgg gccaacgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccggatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  134
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  134

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Ala Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asp 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  135
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  135
atgagcaccg ctattgtcac caacgtcaaa cattttgggg gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatcgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  136
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  136

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Ser Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  137
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  137
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaacgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  138
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  138

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  139
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  139
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aggcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgactta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  140
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  140

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Thr 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  141
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  141
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgactta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  142
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  142

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Thr 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  143
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  143
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatcgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  144
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  144

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Ser Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  145
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  145
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatcgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  146
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  146

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Ser Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  147
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  147
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgactta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  148
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  148

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Thr 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  149
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  149
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ccgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgactta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtgact      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  150
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  150

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Pro Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Thr 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Thr His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  151
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  151
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat gaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tattcgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  152
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  152

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Ser Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  153
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  153
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggcttgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  154
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  154

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Leu Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  155
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  155
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cgcgtgcgta gggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  156
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  156

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Arg Val Arg Arg Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  157
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  157
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttacccttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  158
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  158

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Pro Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  159
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  159
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccggatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  160
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  160

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asp 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  161
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  161
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg ttgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaacgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccggatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccg ggcatgcccg aataa                      765


<210>  162
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  162

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asp 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  163
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  163
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccggatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  164
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  164

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asp 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  165
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  165
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaacgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacacacg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  166
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  166

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  167
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  167
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatcgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccggatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  168
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  168

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Ser Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asp 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  169
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  169
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccggatta cctacactcg      540

ggggattcgc cgtaccatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggcttgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  170
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  170

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asp 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr His Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Leu Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  171
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  171
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccggatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  172
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  172

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asp 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  173
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  173
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

tttgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  174
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  174

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Phe Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  175
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  175
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atctgccctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  176
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  176

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Cys Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  177
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  177
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atctttcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  178
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  178

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  179
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  179
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcggccctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  180
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  180

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Gly Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  181
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  181
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcctgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  182
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  182

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Leu Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  183
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  183
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcagccctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  184
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  184

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ser Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  185
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  185
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atctatcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  186
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  186

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  187
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  187
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgtgcg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  188
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  188

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Cys Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  189
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  189
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcggaag tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  190
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  190

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Glu Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  191
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  191
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaagcgcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  192
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  192

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Ala Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  193
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  193
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

gaagcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  194
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  194

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Glu Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  195
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  195
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atggcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  196
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  196

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Met Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  197
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  197
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

tgggcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  198
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  198

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Trp Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  199
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  199
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacaa ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

tatgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  200
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  200

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Tyr Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  201
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  201
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcattcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  202
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  202

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ile Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  203
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  203
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcaaacctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  204
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  204

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Lys Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  205
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  205
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcatgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  206
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  206

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Met Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  207
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  207
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg atgaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  208
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  208

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Asp Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  209
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  209
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatttcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  210
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  210

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  211
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  211
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgtgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaacatcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttctg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  212
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  212

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu His Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Trp Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  213
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  213
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctt gcccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  214
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  214

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Cys Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  215
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  215
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcaaccctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  216
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  216

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Asn Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  217
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  217
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atctggcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  218
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  218

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Trp Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  219
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  219
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgccta ttgaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  220
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  220

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Ile Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  221
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  221
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggcta ttccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  222
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  222

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ile Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  223
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  223
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggcta aaccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  224
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  224

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Lys Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  225
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  225
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctc tgccgttcgg accatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  226
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  226

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Leu Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  227
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  227
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg tgccgttcgg accatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  228
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  228

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Val Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  229
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  229
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagggctcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  230
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  230

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Gly Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  231
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  231
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctt ttccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  232
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  232

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Phe Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  233
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  233
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggcta tgccgttcgg accatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  234
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  234

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Met Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  235
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  235
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagatttcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgaccgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  236
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  236

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  237
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  237
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagatgtcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  238
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  238

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Met Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  239
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  239
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagaactcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  240
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  240

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Asn Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  241
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  241
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagtgctcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  242
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  242

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Cys Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  243
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  243
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  244
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  244

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  245
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  245
atgagcaccg ctattgtcac caacgtcaaa catatgggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcat cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  246
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  246

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Met Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Ile Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  247
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  247
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctttgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtggcgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  248
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  248

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Leu Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  249
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  249
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggcta ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  250
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  250

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  251
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  251
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta ctgtcactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  252
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  252

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Cys His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  253
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  253
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cgtgcactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  254
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  254

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Val His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  255
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  255
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ttgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta ctgtcactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  256
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  256

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Val Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Cys His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  257
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  257
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactttta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  258
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  258

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Phe Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  259
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  259
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatctaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgtgttccc ggcatgcccg aataa                      765


<210>  260
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  260

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Ser Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Val Pro Gly Met Pro Glu 
                245                 250                 


<210>  261
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  261
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaactaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgtcatccc ggcatgcccg aataa                      765


<210>  262
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  262

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg His Pro Gly Met Pro Glu 
                245                 250                 


<210>  263
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  263
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacggttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgtcctccc ggcatgcccg aataa                      765


<210>  264
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  264

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Val Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Pro Pro Gly Met Pro Glu 
                245                 250                 


<210>  265
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  265
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaacgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  266
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  266

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  267
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  267
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  268
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  268

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  269
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  269
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatcgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgactta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  270
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  270

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Ser Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Thr 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  271
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  271
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag cttgtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgactta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  272
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  272

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Cys His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Thr 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  273
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  273
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgcggaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgtt      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccgtcgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  274
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  274

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Val 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Ser Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  275
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  275
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaagtgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccggg gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  276
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  276

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Val Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Gly His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  277
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  277
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatggaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcttggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaacgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctttcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  278
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  278

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  279
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  279
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaacgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccggatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  280
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  280

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asp 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  281
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  281
atgagctccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  282
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  282

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  283
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  283
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaacgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgagtta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  284
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  284

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  285
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  285
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctgcactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggca      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  286
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  286

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  287
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  287
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcggggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctcgc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  288
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  288

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  289
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  289
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggactggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaatgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tgtcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  290
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  290

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Asp Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Met Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  291
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  291
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccaacgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cgcgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcctgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  292
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  292

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Thr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Arg Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  293
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  293
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcacac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagcgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatcgaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  294
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  294

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Ser Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  295
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  295
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctt gcgaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  296
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  296

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Cys Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  297
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  297
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctt ttgaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  298
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  298

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Phe Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  299
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  299
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

ctggcgcctg tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  300
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  300

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Leu Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  301
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  301
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgcctc tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  302
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  302

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Leu Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  303
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  303
atgagcaccg ctattgtcac caacgtcaaa cattttggag gtatgggtag cgctctgcgt       60

ctgagcgaag ctggtcatac cgtcgcttgc catgatgaaa gctttaagca tcaggatgaa      120

ctagaagctt ttgctgaaac ctacccacag ctgataccaa tgagcgaaca ggaaccagct      180

gaactgattg aagctgtcac cagcgctctt ggtcatgtcg atgtcctggt cagcaacgat      240

atcgcgccta tggaatggcg gccaatcgat aaatacgctg tcgaggatta cagggatact      300

gtcgaagctc tgcagatcaa gccatttgct ctagtgaatg ctgtcgcttc gcaaatgaag      360

aagcgaaagt cggggcacat catcttcatc acttcggctg ccccgttcgg gccatggaag      420

gagctatcga cttactcttc ggctcgagct ggggctagtg cactagctaa tgctctatcg      480

aaggagctag gagagtacaa tatcccggtg ttcgctatcg ctccgaatta cctacactcg      540

ggggattcgc cgtactatta cccctctgag ccgtggaaga cttctccgga gcacgtggct      600

cacgtgcgta aggtgactgc tctacaacga ctagggactc aaaaagagtt gggggaattg      660

gtgacgtttt tggcatctgg ctcttgtgat tatttgactg gccaggtgtt ttggttggca      720

ggcggctttc ccgtcatcga acgttggccc ggcatgcccg aataa                      765


<210>  304
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of halohydrin dehalogenase from A. radiobacter

<400>  304

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Met Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


