                         SEQUENCE LISTING

<110>  Health Protection Agency
 
<120>  Rapid Bioluminescence Detection System

<130>  P31981WO-MRM

<150>  GB 0900151.2
<151>  2009-01-07

<160>  84    

<170>  PatentIn version 3.2

<210>  1
<211>  195
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  1

Met Lys Ile Gly Ile Val Thr Gly Ile Pro Gly Val Gly Lys Thr Thr 
1               5                   10                  15      


Val Leu Ser Phe Ala Asp Lys Ile Leu Thr Glu Lys Gly Ile Ser His 
            20                  25                  30          


Lys Ile Val Asn Tyr Gly Asp Tyr Met Leu Asn Thr Ala Leu Lys Glu 
        35                  40                  45              


Gly Tyr Val Lys Ser Arg Asp Glu Ile Arg Lys Leu Gln Ile Glu Lys 
    50                  55                  60                  


Gln Arg Glu Leu Gln Ala Leu Ala Ala Arg Arg Ile Val Glu Asp Leu 
65                  70                  75                  80  


Ser Leu Leu Gly Asp Glu Gly Ile Gly Leu Ile Asp Thr His Ala Val 
                85                  90                  95      


Ile Arg Thr Pro Ala Gly Tyr Leu Pro Gly Leu Pro Arg His Val Ile 
            100                 105                 110         


Glu Val Leu Ser Pro Lys Val Ile Phe Leu Leu Glu Ala Asp Pro Lys 
        115                 120                 125             


Ile Ile Leu Glu Arg Gln Lys Arg Asp Ser Ser Arg Ala Arg Thr Asp 
    130                 135                 140                 


Tyr Ser Asp Thr Ala Val Ile Asn Glu Val Ile Gln Phe Ala Arg Tyr 
145                 150                 155                 160 


Ser Ala Met Ala Ser Ala Val Leu Val Gly Ala Ser Val Lys Val Val 
                165                 170                 175     


Val Asn Gln Glu Gly Asp Pro Ser Ile Ala Ala Ser Glu Ile Ile Asn 
            180                 185                 190         


Ser Leu Met 
        195 


<210>  2
<211>  194
<212>  PRT
<213>  Sulfolobus acidocaldarius

<400>  2

Met Lys Ile Gly Ile Val Thr Gly Ile Pro Gly Val Gly Lys Ser Thr 
1               5                   10                  15      


Val Leu Ala Lys Val Lys Glu Ile Leu Asp Asn Gln Gly Ile Asn Asn 
            20                  25                  30          


Lys Ile Ile Asn Tyr Gly Asp Phe Met Leu Ala Thr Ala Leu Lys Leu 
        35                  40                  45              


Gly Tyr Ala Lys Asp Arg Asp Glu Met Arg Lys Leu Ser Val Glu Lys 
    50                  55                  60                  


Gln Lys Lys Leu Gln Ile Asp Ala Ala Lys Gly Ile Ala Glu Glu Ala 
65                  70                  75                  80  


Arg Ala Gly Gly Glu Gly Tyr Leu Phe Ile Asp Thr His Ala Val Ile 
                85                  90                  95      


Arg Thr Pro Ser Gly Tyr Leu Pro Gly Leu Pro Ser Tyr Val Ile Thr 
            100                 105                 110         


Glu Ile Asn Pro Ser Val Ile Phe Leu Leu Glu Ala Asp Pro Lys Ile 
        115                 120                 125             


Ile Leu Ser Arg Gln Lys Arg Asp Thr Thr Arg Asn Arg Asn Asp Tyr 
    130                 135                 140                 


Ser Asp Glu Ser Val Ile Leu Glu Thr Ile Asn Phe Ala Arg Tyr Ala 
145                 150                 155                 160 


Ala Thr Ala Ser Ala Val Leu Ala Gly Ser Thr Val Lys Val Ile Val 
                165                 170                 175     


Asn Val Glu Gly Asp Pro Ser Ile Ala Ala Asn Glu Ile Ile Arg Ser 
            180                 185                 190         


Met Lys 
        


<210>  3
<211>  197
<212>  PRT
<213>  Sulfolobus tokodaii

<400>  3

Met Ser Lys Met Lys Ile Gly Ile Val Thr Gly Ile Pro Gly Val Gly 
1               5                   10                  15      


Lys Thr Thr Val Leu Ser Lys Val Lys Glu Ile Leu Glu Glu Lys Lys 
            20                  25                  30          


Ile Asn Asn Lys Ile Val Asn Tyr Gly Asp Tyr Met Leu Met Thr Ala 
        35                  40                  45              


Met Lys Leu Gly Tyr Val Asn Asn Arg Asp Glu Met Arg Lys Leu Pro 
    50                  55                  60                  


Val Glu Lys Gln Lys Gln Leu Gln Ile Glu Ala Ala Arg Gly Ile Ala 
65                  70                  75                  80  


Asn Glu Ala Lys Glu Gly Gly Asp Gly Leu Leu Phe Ile Asp Thr His 
                85                  90                  95      


Ala Val Ile Arg Thr Pro Ser Gly Tyr Leu Pro Gly Leu Pro Lys Tyr 
            100                 105                 110         


Val Ile Glu Glu Ile Asn Pro Arg Val Ile Phe Leu Leu Glu Ala Asp 
        115                 120                 125             


Pro Lys Val Ile Leu Asp Arg Gln Lys Arg Asp Thr Ser Arg Ser Arg 
    130                 135                 140                 


Ser Asp Tyr Ser Asp Glu Arg Ile Ile Ser Glu Thr Ile Asn Phe Ala 
145                 150                 155                 160 


Arg Tyr Ala Ala Met Ala Ser Ala Val Leu Val Gly Ala Thr Val Lys 
                165                 170                 175     


Ile Val Ile Asn Val Glu Gly Asp Pro Ala Val Ala Ala Asn Glu Ile 
            180                 185                 190         


Ile Asn Ser Met Leu 
        195         


<210>  4
<211>  196
<212>  PRT
<213>  Pyrococcus furiosus

<400>  4

Met Pro Phe Val Val Ile Ile Thr Gly Ile Pro Gly Val Gly Lys Ser 
1               5                   10                  15      


Thr Ile Thr Arg Leu Ala Leu Gln Arg Thr Lys Ala Lys Phe Arg Leu 
            20                  25                  30          


Ile Asn Phe Gly Asp Leu Met Phe Glu Glu Ala Val Lys Ala Gly Leu 
        35                  40                  45              


Val Lys His Arg Asp Glu Met Arg Lys Leu Pro Leu Lys Ile Gln Arg 
    50                  55                  60                  


Glu Leu Gln Met Lys Ala Ala Lys Lys Ile Thr Glu Met Ala Lys Glu 
65                  70                  75                  80  


His Pro Ile Leu Val Asp Thr His Ala Thr Ile Lys Thr Pro His Gly 
                85                  90                  95      


Tyr Met Leu Gly Leu Pro Tyr Glu Val Val Lys Thr Leu Asn Pro Asn 
            100                 105                 110         


Phe Ile Val Ile Ile Glu Ala Thr Pro Ser Glu Ile Leu Gly Arg Arg 
        115                 120                 125             


Leu Arg Asp Leu Lys Arg Asp Arg Asp Val Glu Thr Glu Glu Gln Ile 
    130                 135                 140                 


Gln Arg His Gln Asp Leu Asn Arg Ala Ala Ala Ile Ala Tyr Ala Met 
145                 150                 155                 160 


His Ser Asn Ala Leu Ile Lys Ile Ile Glu Asn His Glu Asp Lys Gly 
                165                 170                 175     


Leu Glu Glu Ala Val Asn Glu Leu Val Lys Ile Leu Asp Leu Ala Val 
            180                 185                 190         


Asn Glu Tyr Ala 
        195     


<210>  5
<211>  196
<212>  PRT
<213>  Pyrococcus horikoshii

<400>  5

Met Pro Phe Val Val Ile Ile Thr Gly Ile Pro Gly Val Gly Lys Ser 
1               5                   10                  15      


Thr Ile Thr Lys Leu Ala Leu Gln Arg Thr Arg Ala Lys Phe Lys Leu 
            20                  25                  30          


Ile Asn Phe Gly Asp Leu Met Phe Glu Glu Ala Leu Lys Leu Lys Leu 
        35                  40                  45              


Val Lys His Arg Asp Glu Met Arg Lys Leu Pro Leu Glu Val Gln Arg 
    50                  55                  60                  


Glu Leu Gln Met Asn Ala Ala Lys Lys Ile Ala Glu Met Ala Lys Asn 
65                  70                  75                  80  


Tyr Pro Ile Leu Leu Asp Thr His Ala Thr Ile Lys Thr Pro His Gly 
                85                  90                  95      


Tyr Leu Leu Gly Leu Pro Tyr Glu Val Ile Lys Ile Leu Asn Pro Asn 
            100                 105                 110         


Phe Ile Val Ile Ile Glu Ala Thr Pro Ser Glu Ile Leu Gly Arg Arg 
        115                 120                 125             


Leu Arg Asp Leu Lys Arg Asp Arg Asp Val Glu Thr Glu Glu Gln Ile 
    130                 135                 140                 


Gln Arg His Gln Asp Leu Asn Arg Ala Ala Ala Ile Thr Tyr Ala Met 
145                 150                 155                 160 


His Ser Asn Ala Leu Ile Lys Ile Ile Glu Asn His Glu Asp Lys Gly 
                165                 170                 175     


Leu Glu Glu Ala Val Asn Glu Leu Val Lys Ile Leu Asp Leu Ala Val 
            180                 185                 190         


Lys Glu Tyr Ala 
        195     


<210>  6
<211>  196
<212>  PRT
<213>  Pyrococcus abyssi

<400>  6

Met Ser Phe Val Val Ile Ile Thr Gly Ile Pro Gly Val Gly Lys Ser 
1               5                   10                  15      


Thr Ile Thr Arg Leu Ala Leu Gln Arg Thr Lys Ala Lys Phe Lys Leu 
            20                  25                  30          


Ile Asn Phe Gly Asp Leu Met Phe Glu Glu Ala Val Lys Ala Gly Leu 
        35                  40                  45              


Val Asn His Arg Asp Glu Met Arg Lys Leu Pro Leu Glu Ile Gln Arg 
    50                  55                  60                  


Asp Leu Gln Met Lys Val Ala Lys Lys Ile Ser Glu Met Ala Arg Gln 
65                  70                  75                  80  


Gln Pro Ile Leu Leu Asp Thr His Ala Thr Ile Lys Thr Pro His Gly 
                85                  90                  95      


Tyr Leu Leu Gly Leu Pro Tyr Glu Val Ile Lys Thr Leu Asn Pro Asn 
            100                 105                 110         


Phe Ile Val Ile Ile Glu Ala Thr Pro Ser Glu Ile Leu Gly Arg Arg 
        115                 120                 125             


Leu Arg Asp Leu Lys Arg Asp Arg Asp Val Glu Thr Glu Glu Gln Ile 
    130                 135                 140                 


Gln Arg His Gln Asp Leu Asn Arg Ala Ala Ala Ile Ala Tyr Ala Met 
145                 150                 155                 160 


His Ser Asn Ala Leu Ile Lys Ile Ile Glu Asn His Glu Asp Lys Gly 
                165                 170                 175     


Leu Glu Glu Ala Val Asn Glu Leu Val Glu Ile Leu Asp Leu Ala Val 
            180                 185                 190         


Lys Glu Tyr Ala 
        195     


<210>  7
<211>  192
<212>  PRT
<213>  Methanococcus thermolithotrophicus

<400>  7

Met Lys Asn Lys Leu Val Val Val Thr Gly Val Pro Gly Val Gly Gly 
1               5                   10                  15      


Thr Thr Ile Thr Gln Lys Ala Met Glu Lys Leu Ser Glu Glu Gly Ile 
            20                  25                  30          


Asn Tyr Lys Met Val Asn Phe Gly Thr Val Met Phe Glu Val Ala Gln 
        35                  40                  45              


Glu Glu Asn Leu Val Glu Asp Arg Asp Gln Met Arg Lys Leu Asp Pro 
    50                  55                  60                  


Asp Thr Gln Lys Arg Ile Gln Lys Leu Ala Gly Arg Lys Ile Ala Glu 
65                  70                  75                  80  


Met Val Lys Glu Ser Pro Val Val Val Asp Thr His Ser Thr Ile Lys 
                85                  90                  95      


Thr Pro Lys Gly Tyr Leu Pro Gly Leu Pro Val Trp Val Leu Asn Glu 
            100                 105                 110         


Leu Asn Pro Asp Ile Ile Ile Val Val Glu Thr Ser Gly Asp Glu Ile 
        115                 120                 125             


Leu Ile Arg Arg Leu Asn Asp Glu Thr Arg Asn Arg Asp Leu Glu Thr 
    130                 135                 140                 


Thr Ala Gly Ile Glu Glu His Gln Ile Met Asn Arg Ala Ala Ala Met 
145                 150                 155                 160 


Thr Tyr Gly Val Leu Thr Gly Ala Thr Val Lys Ile Ile Gln Asn Lys 
                165                 170                 175     


Asn Asn Leu Leu Asp Tyr Ala Val Glu Glu Leu Ile Ser Val Leu Arg 
            180                 185                 190         


<210>  8
<211>  192
<212>  PRT
<213>  Methanococcus voltae

<400>  8

Met Lys Asn Lys Val Val Val Val Thr Gly Val Pro Gly Val Gly Ser 
1               5                   10                  15      


Thr Thr Ser Ser Gln Leu Ala Met Asp Asn Leu Arg Lys Glu Gly Val 
            20                  25                  30          


Asn Tyr Lys Met Val Ser Phe Gly Ser Val Met Phe Glu Val Ala Lys 
        35                  40                  45              


Glu Glu Asn Leu Val Ser Asp Arg Asp Gln Met Arg Lys Met Asp Pro 
    50                  55                  60                  


Glu Thr Gln Lys Arg Ile Gln Lys Met Ala Gly Arg Lys Ile Ala Glu 
65                  70                  75                  80  


Met Ala Lys Glu Ser Pro Val Ala Val Asp Thr His Ser Thr Val Ser 
                85                  90                  95      


Thr Pro Lys Gly Tyr Leu Pro Gly Leu Pro Ser Trp Val Leu Asn Glu 
            100                 105                 110         


Leu Asn Pro Asp Leu Ile Ile Val Val Glu Thr Thr Gly Asp Glu Ile 
        115                 120                 125             


Leu Met Arg Arg Met Ser Asp Glu Thr Arg Val Arg Asp Leu Asp Thr 
    130                 135                 140                 


Ala Ser Thr Ile Glu Gln His Gln Phe Met Asn Arg Cys Ala Ala Met 
145                 150                 155                 160 


Ser Tyr Gly Val Leu Thr Gly Ala Thr Val Lys Ile Val Gln Asn Arg 
                165                 170                 175     


Asn Gly Leu Leu Asp Gln Ala Val Glu Glu Leu Thr Asn Val Leu Arg 
            180                 185                 190         


<210>  9
<211>  195
<212>  PRT
<213>  Methanococcus jannaschii

<400>  9

Met Met Met Met Lys Asn Lys Val Val Val Ile Val Gly Val Pro Gly 
1               5                   10                  15      


Val Gly Ser Thr Thr Val Thr Asn Lys Ala Ile Glu Glu Leu Lys Lys 
            20                  25                  30          


Glu Gly Ile Glu Tyr Lys Ile Val Asn Phe Gly Thr Val Met Phe Glu 
        35                  40                  45              


Ile Ala Lys Glu Glu Gly Leu Val Glu His Arg Asp Gln Leu Arg Lys 
    50                  55                  60                  


Leu Pro Pro Glu Glu Gln Lys Arg Ile Gln Lys Leu Ala Gly Lys Lys 
65                  70                  75                  80  


Ile Ala Glu Met Ala Lys Glu Phe Asn Ile Val Val Asp Thr His Ser 
                85                  90                  95      


Thr Ile Lys Thr Pro Lys Gly Tyr Leu Pro Gly Leu Pro Ala Trp Val 
            100                 105                 110         


Leu Glu Glu Leu Asn Pro Asp Ile Ile Val Leu Val Glu Ala Glu Asn 
        115                 120                 125             


Asp Glu Ile Leu Met Arg Arg Leu Lys Asp Glu Thr Arg Gln Arg Asp 
    130                 135                 140                 


Phe Glu Ser Thr Glu Asp Ile Gly Glu His Ile Phe Met Asn Arg Cys 
145                 150                 155                 160 


Ala Ala Met Thr Tyr Ala Val Leu Thr Gly Ala Thr Val Lys Ile Ile 
                165                 170                 175     


Lys Asn Arg Asp Phe Leu Leu Asp Lys Ala Val Gln Glu Leu Ile Glu 
            180                 185                 190         


Val Leu Lys 
        195 


<210>  10
<211>  191
<212>  PRT
<213>  Methanopyrus kandleri

<400>  10

Met Gly Tyr Val Ile Val Ala Thr Gly Val Pro Gly Val Gly Ala Thr 
1               5                   10                  15      


Thr Val Thr Thr Glu Ala Val Lys Glu Leu Glu Gly Tyr Glu His Val 
            20                  25                  30          


Asn Tyr Gly Asp Val Met Leu Glu Ile Ala Lys Glu Glu Gly Leu Val 
        35                  40                  45              


Glu His Arg Asp Glu Ile Arg Lys Leu Pro Ala Glu Lys Gln Arg Glu 
    50                  55                  60                  


Ile Gln Arg Leu Ala Ala Arg Arg Ile Ala Lys Met Ala Glu Glu Lys 
65                  70                  75                  80  


Glu Gly Ile Ile Val Asp Thr His Cys Thr Ile Lys Thr Pro Ala Gly 
                85                  90                  95      


Tyr Leu Pro Gly Leu Pro Ile Trp Val Leu Glu Glu Leu Gln Pro Asp 
            100                 105                 110         


Val Ile Val Leu Ile Glu Ala Asp Pro Asp Glu Ile Met Met Arg Arg 
        115                 120                 125             


Val Lys Asp Ser Glu Glu Arg Gln Arg Asp Tyr Asp Arg Ala His Glu 
    130                 135                 140                 


Ile Glu Glu His Gln Lys Met Asn Arg Met Ala Ala Met Ala Tyr Ala 
145                 150                 155                 160 


Ala Leu Thr Gly Ala Thr Val Lys Ile Ile Glu Asn His Asp Asp Arg 
                165                 170                 175     


Leu Glu Glu Ala Val Arg Glu Phe Val Glu Thr Val Arg Ser Leu 
            180                 185                 190     


<210>  11
<211>  192
<212>  PRT
<213>  Methanotorris igneus

<400>  11

Met Lys Asn Lys Val Val Val Val Thr Gly Val Pro Gly Val Gly Gly 
1               5                   10                  15      


Thr Thr Leu Thr Gln Lys Thr Ile Glu Lys Leu Lys Glu Glu Gly Ile 
            20                  25                  30          


Glu Tyr Lys Met Val Asn Phe Gly Thr Val Met Phe Glu Val Ala Lys 
        35                  40                  45              


Glu Glu Gly Leu Val Glu Asp Arg Asp Gln Met Arg Lys Leu Asp Pro 
    50                  55                  60                  


Asp Thr Gln Lys Arg Ile Gln Lys Leu Ala Gly Arg Lys Ile Ala Glu 
65                  70                  75                  80  


Met Ala Lys Glu Ser Asn Val Ile Val Asp Thr His Ser Thr Val Lys 
                85                  90                  95      


Thr Pro Lys Gly Tyr Leu Ala Gly Leu Pro Ile Trp Val Leu Glu Glu 
            100                 105                 110         


Leu Asn Pro Asp Ile Ile Val Ile Val Glu Thr Ser Ser Asp Glu Ile 
        115                 120                 125             


Leu Met Arg Arg Leu Gly Asp Ala Thr Arg Asn Arg Asp Ile Glu Leu 
    130                 135                 140                 


Thr Ser Asp Ile Asp Glu His Gln Phe Met Asn Arg Cys Ala Ala Met 
145                 150                 155                 160 


Ala Tyr Gly Val Leu Thr Gly Ala Thr Val Lys Ile Ile Lys Asn Arg 
                165                 170                 175     


Asp Gly Leu Leu Asp Lys Ala Val Glu Glu Leu Ile Ser Val Leu Lys 
            180                 185                 190         


<210>  12
<211>  197
<212>  PRT
<213>  Pyrobaculum aerophilum

<400>  12

Met Lys Ile Val Ile Val Ala Leu Pro Gly Ser Gly Lys Thr Thr Ile 
1               5                   10                  15      


Leu Asn Phe Val Lys Gln Lys Leu Pro Asp Val Lys Ile Val Asn Tyr 
            20                  25                  30          


Gly Asp Val Met Leu Glu Ile Ala Lys Lys Arg Phe Gly Ile Gln His 
        35                  40                  45              


Arg Asp Glu Met Arg Lys Lys Ile Pro Val Asp Glu Tyr Arg Lys Val 
    50                  55                  60                  


Gln Glu Glu Ala Ala Glu Tyr Ile Ala Ser Leu Thr Gly Asp Val Ile 
65                  70                  75                  80  


Ile Asp Thr His Ala Ser Ile Lys Ile Gly Gly Gly Tyr Tyr Pro Gly 
                85                  90                  95      


Leu Pro Asp Arg Ile Ile Ser Lys Leu Lys Pro Asp Val Ile Leu Leu 
            100                 105                 110         


Leu Glu Tyr Asp Pro Lys Val Ile Leu Glu Arg Arg Lys Lys Asp Pro 
        115                 120                 125             


Asp Arg Phe Arg Asp Leu Glu Ser Glu Glu Glu Ile Glu Met His Gln 
    130                 135                 140                 


Gln Ala Asn Arg Tyr Tyr Ala Phe Ala Ala Ala Asn Ala Gly Glu Ser 
145                 150                 155                 160 


Thr Val His Val Leu Asn Phe Arg Gly Lys Pro Glu Ser Arg Pro Phe 
                165                 170                 175     


Glu His Ala Glu Val Ala Ala Glu Tyr Ile Val Asn Leu Ile Leu Arg 
            180                 185                 190         


Thr Arg Gln Lys Ser 
        195         


<210>  13
<211>  220
<212>  PRT
<213>  Thermotoga maritima

<400>  13

Met Met Ala Tyr Leu Val Phe Leu Gly Pro Pro Gly Ala Gly Lys Gly 
1               5                   10                  15      


Thr Tyr Ala Lys Arg Ile Gln Glu Lys Thr Gly Ile Pro His Ile Ser 
            20                  25                  30          


Thr Gly Asp Ile Phe Arg Asp Ile Val Lys Lys Glu Asn Asp Glu Leu 
        35                  40                  45              


Gly Lys Lys Ile Lys Glu Ile Met Glu Lys Gly Glu Leu Val Pro Asp 
    50                  55                  60                  


Glu Leu Val Asn Glu Val Val Lys Arg Arg Leu Ser Glu Lys Asp Cys 
65                  70                  75                  80  


Glu Lys Gly Phe Ile Leu Asp Gly Tyr Pro Arg Thr Val Ala Gln Ala 
                85                  90                  95      


Glu Phe Leu Asp Ser Phe Leu Glu Ser Gln Asn Lys Gln Leu Thr Ala 
            100                 105                 110         


Ala Val Leu Phe Asp Val Pro Glu Asp Val Val Val Gln Arg Leu Thr 
        115                 120                 125             


Ser Arg Arg Ile Cys Pro Lys Cys Gly Arg Ile Tyr Asn Met Ile Ser 
    130                 135                 140                 


Leu Pro Pro Lys Glu Asp Glu Leu Cys Asp Asp Cys Lys Val Lys Leu 
145                 150                 155                 160 


Val Gln Arg Asp Asp Asp Lys Glu Glu Thr Val Arg His Arg Tyr Lys 
                165                 170                 175     


Val Tyr Leu Glu Lys Thr Gln Pro Val Ile Asp Tyr Tyr Gly Lys Lys 
            180                 185                 190         


Gly Ile Leu Lys Arg Val Asp Gly Thr Ile Gly Ile Asp Asn Val Val 
        195                 200                 205             


Ala Glu Val Leu Lys Ile Ile Gly Trp Ser Asp Lys 
    210                 215                 220 


<210>  14
<211>  204
<212>  PRT
<213>  Aeropyrum pernix

<400>  14

Met Lys Val Arg His Pro Phe Lys Val Val Val Val Thr Gly Val Pro 
1               5                   10                  15      


Gly Val Gly Lys Thr Thr Val Ile Lys Glu Leu Gln Gly Leu Ala Glu 
            20                  25                  30          


Lys Glu Gly Val Lys Leu His Ile Val Asn Phe Gly Ser Phe Met Leu 
        35                  40                  45              


Asp Thr Ala Val Lys Leu Gly Leu Val Glu Asp Arg Asp Lys Ile Arg 
    50                  55                  60                  


Thr Leu Pro Leu Arg Arg Gln Leu Glu Leu Gln Arg Glu Ala Ala Lys 
65                  70                  75                  80  


Arg Ile Val Ala Glu Ala Ser Lys Ala Leu Gly Gly Asp Gly Val Leu 
                85                  90                  95      


Ile Ile Asp Thr His Ala Leu Val Lys Thr Val Ala Gly Tyr Trp Pro 
            100                 105                 110         


Gly Leu Pro Lys His Val Leu Asp Glu Leu Lys Pro Asp Met Ile Ala 
        115                 120                 125             


Val Val Glu Ala Ser Pro Glu Glu Val Ala Ala Arg Gln Ala Arg Asp 
    130                 135                 140                 


Thr Thr Arg Tyr Arg Val Asp Ile Gly Gly Val Glu Gly Val Lys Arg 
145                 150                 155                 160 


Leu Met Glu Asn Ala Arg Ala Ala Ser Ile Ala Ser Ala Ile Gln Tyr 
                165                 170                 175     


Ala Ser Thr Val Ala Ile Val Glu Asn Arg Glu Gly Glu Ala Ala Lys 
            180                 185                 190         


Ala Ala Glu Glu Leu Leu Arg Leu Ile Lys Asn Leu 
        195                 200                 


<210>  15
<211>  216
<212>  PRT
<213>  Archaeoglobus fulgidus

<400>  15

Met Asn Leu Ile Phe Leu Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln 
1               5                   10                  15      


Ala Lys Arg Val Ser Glu Lys Tyr Gly Ile Pro Gln Ile Ser Thr Gly 
            20                  25                  30          


Asp Met Leu Arg Glu Ala Val Ala Lys Gly Thr Glu Leu Gly Lys Lys 
        35                  40                  45              


Ala Lys Glu Tyr Met Asp Lys Gly Glu Leu Val Pro Asp Glu Val Val 
    50                  55                  60                  


Ile Gly Ile Val Lys Glu Arg Leu Gln Gln Pro Asp Cys Glu Lys Gly 
65                  70                  75                  80  


Phe Ile Leu Asp Gly Phe Pro Arg Thr Leu Ala Gln Ala Glu Ala Leu 
                85                  90                  95      


Asp Glu Met Leu Lys Glu Leu Asn Lys Lys Ile Asp Ala Val Ile Asn 
            100                 105                 110         


Val Val Val Pro Glu Glu Glu Val Val Lys Arg Ile Thr Tyr Arg Arg 
        115                 120                 125             


Thr Cys Arg Asn Cys Gly Ala Val Tyr His Leu Ile Tyr Ala Pro Pro 
    130                 135                 140                 


Lys Glu Asp Asn Lys Cys Asp Lys Cys Gly Gly Glu Leu Tyr Gln Arg 
145                 150                 155                 160 


Asp Asp Lys Glu Glu Thr Val Arg Glu Arg Tyr Arg Val Tyr Lys Gln 
                165                 170                 175     


Asn Thr Glu Pro Leu Ile Asp Tyr Tyr Arg Lys Lys Gly Ile Leu Tyr 
            180                 185                 190         


Asp Val Asp Gly Thr Lys Asp Ile Glu Gly Val Trp Lys Glu Ile Glu 
        195                 200                 205             


Ala Ile Leu Glu Lys Ile Lys Ser 
    210                 215     


<210>  16
<211>  220
<212>  PRT
<213>  Pyrococcus abyssi

<400>  16

Met Asn Ile Leu Ile Phe Gly Pro Pro Gly Ser Gly Lys Ser Thr Gln 
1               5                   10                  15      


Ala Arg Arg Ile Thr Glu Arg Tyr Gly Leu Thr Tyr Ile Ala Ser Gly 
            20                  25                  30          


Asp Ile Ile Arg Ala Glu Ile Lys Ala Arg Thr Pro Leu Gly Ile Glu 
        35                  40                  45              


Met Glu Arg Tyr Leu Ser Arg Gly Asp Leu Ile Pro Asp Thr Ile Val 
    50                  55                  60                  


Asn Thr Leu Ile Ile Ser Lys Leu Arg Arg Val Arg Glu Asn Phe Ile 
65                  70                  75                  80  


Met Asp Gly Tyr Pro Arg Thr Pro Glu Gln Val Ile Thr Leu Glu Asn 
                85                  90                  95      


Tyr Leu Tyr Asp His Gly Ile Lys Leu Asp Val Ala Ile Asp Ile Tyr 
            100                 105                 110         


Ile Thr Lys Glu Glu Ser Val Arg Arg Ile Ser Gly Arg Arg Ile Cys 
        115                 120                 125             


Ser Lys Cys Gly Ala Val Tyr His Val Glu Phe Asn Pro Pro Lys Val 
    130                 135                 140                 


Pro Gly Lys Cys Asp Ile Cys Gly Gly Glu Leu Ile Gln Arg Pro Asp 
145                 150                 155                 160 


Asp Arg Pro Glu Ile Val Glu Lys Arg Tyr Asp Ile Tyr Ser Lys Asn 
                165                 170                 175     


Met Glu Pro Ile Ile Lys Phe Tyr Gln Lys Gln Gly Ile Tyr Val Arg 
            180                 185                 190         


Ile Asp Gly His Gly Ser Ile Asp Glu Val Trp Glu Arg Ile Arg Pro 
        195                 200                 205             


Leu Leu Asp Tyr Ile Tyr Asn Gln Glu Asn Arg Arg 
    210                 215                 220 


<210>  17
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  The amino acid "X" may be K or E.

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  The amino acid "X" may be T or A.

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  The amino acid "X" may be M or L.

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  The amino acid "X" may be A, or a small hydrophobic residue (e.g.
       I or L) or a large hydrophobic residue (e.g. F), that increases 
       the thermal stability of the enzyme.

<400>  17

Met Pro Phe Val Val Ile Ile Thr Gly Ile Pro Gly Val Gly Lys Ser 
1               5                   10                  15      


Thr Ile Thr Arg Leu Ala Leu Gln Arg Thr Lys Ala Lys Phe Arg Leu 
            20                  25                  30          


Ile Asn Phe Gly Asp Leu Met Phe Glu Glu Ala Val Lys Ala Gly Leu 
        35                  40                  45              


Val Lys His Arg Asp Glu Met Arg Lys Leu Pro Leu Xaa Ile Gln Arg 
    50                  55                  60                  


Glu Leu Gln Met Lys Ala Ala Lys Lys Ile Xaa Glu Met Ala Lys Glu 
65                  70                  75                  80  


His Pro Ile Leu Val Asp Thr His Ala Thr Ile Lys Thr Pro His Gly 
                85                  90                  95      


Tyr Xaa Leu Gly Leu Pro Tyr Glu Val Val Lys Thr Leu Asn Pro Asn 
            100                 105                 110         


Phe Ile Val Ile Ile Glu Ala Thr Pro Ser Glu Ile Leu Gly Arg Arg 
        115                 120                 125             


Leu Arg Asp Leu Lys Arg Asp Arg Asp Val Glu Thr Glu Glu Gln Ile 
    130                 135                 140                 


Gln Arg His Gln Asp Leu Asn Arg Ala Ala Ala Ile Xaa Tyr Ala Met 
145                 150                 155                 160 


His Ser Asn Ala Leu Ile Lys Ile Ile Glu Asn His Glu Asp Lys Gly 
                165                 170                 175     


Leu Glu Glu Ala Val Asn Glu Leu Val Lys Ile Leu Asp Leu Ala Val 
            180                 185                 190         


Asn Glu Tyr Ala 
        195     


<210>  18
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  The amino acid "X" may be G, or may be any other residue that 
       increases the thermal stability of the enzyme.

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  The amino acid "X" may be A, or a small hydrophobic residue (e.g.
       I or L) or a large hydrophobic residue (e.g. F), that increases 
       the thermal stability of the enzyme.

<400>  18

Met Pro Phe Val Val Ile Ile Thr Gly Ile Pro Gly Val Gly Lys Ser 
1               5                   10                  15      


Thr Ile Thr Lys Leu Ala Leu Gln Arg Thr Arg Ala Lys Phe Lys Leu 
            20                  25                  30          


Ile Asn Phe Gly Asp Leu Met Phe Glu Glu Ala Leu Lys Leu Xaa Leu 
        35                  40                  45              


Val Lys His Arg Asp Glu Met Arg Lys Leu Pro Leu Glu Val Gln Arg 
    50                  55                  60                  


Glu Leu Gln Met Asn Ala Ala Lys Lys Ile Ala Glu Met Ala Lys Asn 
65                  70                  75                  80  


Tyr Pro Ile Leu Leu Asp Thr His Ala Thr Ile Lys Thr Pro His Gly 
                85                  90                  95      


Tyr Leu Leu Gly Leu Pro Tyr Glu Val Ile Lys Ile Leu Asn Pro Asn 
            100                 105                 110         


Phe Ile Val Ile Ile Glu Ala Thr Pro Ser Glu Ile Leu Gly Arg Arg 
        115                 120                 125             


Leu Arg Asp Leu Lys Arg Asp Arg Asp Val Glu Thr Glu Glu Gln Ile 
    130                 135                 140                 


Gln Arg His Gln Asp Leu Asn Arg Ala Ala Ala Ile Xaa Tyr Ala Met 
145                 150                 155                 160 


His Ser Asn Ala Leu Ile Lys Ile Ile Glu Asn His Glu Asp Lys Gly 
                165                 170                 175     


Leu Glu Glu Ala Val Asn Glu Leu Val Lys Ile Leu Asp Leu Ala Val 
            180                 185                 190         


Lys Glu Tyr Ala 
        195     


<210>  19
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  The amino acid "X" may be A or M.

<400>  19

Met Lys Ile Gly Ile Val Thr Gly Ile Pro Gly Val Gly Lys Ser Thr 
1               5                   10                  15      


Val Leu Ala Lys Val Lys Glu Ile Leu Asp Asn Gln Gly Ile Asn Asn 
            20                  25                  30          


Lys Ile Ile Asn Tyr Gly Asp Phe Met Leu Ala Thr Ala Leu Lys Leu 
        35                  40                  45              


Gly Tyr Ala Lys Asp Arg Asp Glu Met Arg Lys Leu Ser Val Glu Lys 
    50                  55                  60                  


Gln Lys Lys Leu Gln Ile Asp Ala Ala Lys Gly Ile Ala Glu Glu Ala 
65                  70                  75                  80  


Arg Ala Gly Gly Glu Gly Tyr Leu Phe Ile Asp Thr His Ala Val Ile 
                85                  90                  95      


Arg Thr Pro Ser Gly Tyr Xaa Pro Gly Leu Pro Ser Tyr Val Ile Thr 
            100                 105                 110         


Glu Ile Asn Pro Ser Val Ile Phe Leu Leu Glu Ala Asp Pro Lys Ile 
        115                 120                 125             


Ile Leu Ser Arg Gln Lys Arg Asp Thr Thr Arg Asn Arg Asn Asp Tyr 
    130                 135                 140                 


Ser Asp Glu Ser Val Ile Leu Glu Thr Ile Asn Phe Ala Arg Tyr Ala 
145                 150                 155                 160 


Ala Thr Ala Ser Ala Val Leu Ala Gly Ser Thr Val Lys Val Ile Val 
                165                 170                 175     


Asn Val Glu Gly Asp Pro Ser Ile Ala Ala Asn Glu Ile Ile Arg Ser 
            180                 185                 190         


Met Lys 
        


<210>  20
<211>  403
<212>  PRT
<213>  Thermotoga maritima

<400>  20

Met Arg Val Leu Val Ile Asn Ser Gly Ser Ser Ser Ile Lys Tyr Gln 
1               5                   10                  15      


Leu Ile Glu Met Glu Gly Glu Lys Val Leu Cys Lys Gly Ile Ala Glu 
            20                  25                  30          


Arg Ile Gly Ile Glu Gly Ser Arg Leu Val His Arg Val Gly Asp Glu 
        35                  40                  45              


Lys His Val Ile Glu Arg Glu Leu Pro Asp His Glu Glu Ala Leu Lys 
    50                  55                  60                  


Leu Ile Leu Asn Thr Leu Val Asp Glu Lys Leu Gly Val Ile Lys Asp 
65                  70                  75                  80  


Leu Lys Glu Ile Asp Ala Val Gly His Arg Val Val His Gly Gly Glu 
                85                  90                  95      


Arg Phe Lys Glu Ser Val Leu Val Asp Glu Glu Val Leu Lys Ala Ile 
            100                 105                 110         


Glu Glu Val Ser Pro Leu Ala Pro Leu His Asn Pro Ala Asn Leu Met 
        115                 120                 125             


Gly Ile Lys Ala Ala Met Lys Leu Leu Pro Gly Val Pro Asn Val Ala 
    130                 135                 140                 


Val Phe Asp Thr Ala Phe His Gln Thr Ile Pro Gln Lys Ala Tyr Leu 
145                 150                 155                 160 


Tyr Ala Ile Pro Tyr Glu Tyr Tyr Glu Lys Tyr Lys Ile Arg Arg Tyr 
                165                 170                 175     


Gly Phe His Gly Thr Ser His Arg Tyr Val Ser Lys Arg Ala Ala Glu 
            180                 185                 190         


Ile Leu Gly Lys Lys Leu Glu Glu Leu Lys Ile Ile Thr Cys His Ile 
        195                 200                 205             


Gly Asn Gly Ala Ser Val Ala Ala Val Lys Tyr Gly Lys Cys Val Asp 
    210                 215                 220                 


Thr Ser Met Gly Phe Thr Pro Leu Glu Gly Leu Val Met Gly Thr Arg 
225                 230                 235                 240 


Ser Gly Asp Leu Asp Pro Ala Ile Pro Phe Phe Ile Met Glu Lys Glu 
                245                 250                 255     


Gly Ile Ser Pro Gln Glu Met Tyr Asp Ile Leu Asn Lys Lys Ser Gly 
            260                 265                 270         


Val Tyr Gly Leu Ser Lys Gly Phe Ser Ser Asp Met Arg Asp Ile Glu 
        275                 280                 285             


Glu Ala Ala Leu Lys Gly Asp Glu Trp Cys Lys Leu Val Leu Glu Ile 
    290                 295                 300                 


Tyr Asp Tyr Arg Ile Ala Lys Tyr Ile Gly Ala Tyr Ala Ala Ala Met 
305                 310                 315                 320 


Asn Gly Val Asp Ala Ile Val Phe Thr Ala Gly Val Gly Glu Asn Ser 
                325                 330                 335     


Pro Ile Thr Arg Glu Asp Val Cys Ser Tyr Leu Glu Phe Leu Gly Val 
            340                 345                 350         


Lys Leu Asp Lys Gln Lys Asn Glu Glu Thr Ile Arg Gly Lys Glu Gly 
        355                 360                 365             


Ile Ile Ser Thr Pro Asp Ser Arg Val Lys Val Leu Val Val Pro Thr 
    370                 375                 380                 


Asn Glu Glu Leu Met Ile Ala Arg Asp Thr Lys Glu Ile Val Glu Lys 
385                 390                 395                 400 


Ile Gly Arg 
            


<210>  21
<211>  478
<212>  PRT
<213>  Pyrococcus horikoshii

<400>  21

Met Arg Arg Met Lys Leu Pro Ser His Lys Thr Lys Ile Val Ala Thr 
1               5                   10                  15      


Ile Gly Pro Ala Thr Asn Ser Lys Lys Met Ile Lys Lys Leu Ile Glu 
            20                  25                  30          


Ala Gly Met Asn Val Ala Arg Ile Asn Phe Ser His Gly Thr Phe Glu 
        35                  40                  45              


Glu His Ala Lys Ile Ile Glu Met Val Arg Glu Gln Ser Gln Lys Leu 
    50                  55                  60                  


Asp Arg Arg Val Ala Ile Leu Ala Asp Leu Pro Gly Leu Lys Ile Arg 
65                  70                  75                  80  


Val Gly Glu Ile Lys Gly Gly Tyr Val Glu Leu Glu Arg Gly Glu Lys 
                85                  90                  95      


Val Thr Leu Thr Thr Lys Asp Ile Glu Gly Asp Glu Thr Thr Ile Pro 
            100                 105                 110         


Val Glu Tyr Lys Asp Phe Pro Lys Leu Val Ser Lys Gly Asp Val Ile 
        115                 120                 125             


Tyr Leu Ser Asp Gly Tyr Ile Val Leu Arg Val Glu Asp Val Lys Glu 
    130                 135                 140                 


Asn Glu Val Glu Ala Val Val Ile Ser Gly Gly Lys Leu Phe Ser Arg 
145                 150                 155                 160 


Lys Gly Ile Asn Ile Pro Lys Ala Tyr Leu Pro Val Glu Ala Ile Thr 
                165                 170                 175     


Pro Arg Asp Ile Glu Ile Met Lys Phe Ala Ile Glu His Gly Val Asp 
            180                 185                 190         


Ala Ile Gly Leu Ser Phe Val Gly Asn Val Tyr Asp Val Leu Lys Ala 
        195                 200                 205             


Lys Ser Phe Leu Glu Arg Asn Gly Ala Gly Asp Thr Phe Val Ile Ala 
    210                 215                 220                 


Lys Ile Glu Arg Pro Asp Ala Val Arg Asn Phe Asn Glu Ile Leu Asn 
225                 230                 235                 240 


Ala Ala Asp Gly Ile Met Ile Ala Arg Gly Asp Leu Gly Val Glu Met 
                245                 250                 255     


Pro Ile Glu Gln Leu Pro Ile Leu Gln Lys Arg Leu Ile Arg Lys Ala 
            260                 265                 270         


Asn Met Glu Gly Lys Pro Val Ile Thr Ala Thr Gln Met Leu Val Ser 
        275                 280                 285             


Met Thr Met Glu Lys Val Pro Thr Arg Ala Glu Val Thr Asp Val Ala 
    290                 295                 300                 


Asn Ala Ile Leu Asp Gly Thr Asp Ala Val Met Leu Ser Glu Glu Thr 
305                 310                 315                 320 


Ala Val Gly Lys Phe Pro Ile Glu Ala Val Glu Met Met Ala Arg Ile 
                325                 330                 335     


Ala Lys Val Thr Glu Glu Tyr Arg Glu Ser Phe Gly Ile Thr Arg Met 
            340                 345                 350         


Arg Glu Phe Leu Glu Gly Thr Lys Arg Gly Thr Ile Lys Glu Ala Ile 
        355                 360                 365             


Thr Arg Ser Ile Ile Asp Ala Ile Cys Thr Ile Gly Ile Lys Phe Ile 
    370                 375                 380                 


Leu Thr Pro Thr Lys Thr Gly Arg Thr Ala Arg Leu Ile Ser Arg Phe 
385                 390                 395                 400 


Lys Pro Lys Gln Trp Ile Leu Ala Phe Ser Thr Arg Glu Lys Val Cys 
                405                 410                 415     


Asn Asn Leu Met Phe Ser Tyr Gly Val Tyr Pro Phe Cys Met Glu Glu 
            420                 425                 430         


Gly Phe Asn Glu Asn Asp Ile Val Arg Leu Ile Lys Gly Leu Gly Leu 
        435                 440                 445             


Val Gly Ser Asp Asp Ile Val Leu Met Thr Glu Gly Lys Pro Ile Glu 
    450                 455                 460                 


Lys Thr Val Gly Thr Asn Ser Ile Lys Ile Phe Gln Ile Ala 
465                 470                 475             


<210>  22
<211>  452
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  22

Met Arg Lys Thr Lys Ile Val Ala Thr Leu Gly Pro Ser Ser Glu Glu 
1               5                   10                  15      


Lys Val Lys Glu Leu Ala Glu Tyr Val Asp Val Phe Arg Ile Asn Phe 
            20                  25                  30          


Ala His Gly Asp Glu Thr Ser His Arg Lys Tyr Phe Asp Leu Ile Arg 
        35                  40                  45              


Thr Tyr Ala Pro Glu Ser Ser Ile Ile Val Asp Leu Pro Gly Pro Lys 
    50                  55                  60                  


Leu Arg Leu Gly Glu Leu Lys Glu Pro Ile Glu Val Lys Lys Gly Asp 
65                  70                  75                  80  


Lys Ile Val Phe Ser Gln Lys Asp Gly Ile Pro Val Asp Asp Glu Leu 
                85                  90                  95      


Phe Tyr Ser Ala Val Lys Glu Asn Ser Asp Ile Leu Ile Ala Asp Gly 
            100                 105                 110         


Thr Ile Arg Val Arg Val Lys Ser Lys Ala Lys Asp Arg Val Glu Gly 
        115                 120                 125             


Thr Val Ile Glu Gly Gly Ile Leu Leu Ser Arg Lys Gly Ile Asn Ile 
    130                 135                 140                 


Pro Asn Val Asn Leu Lys Ser Gly Ile Thr Asp Asn Asp Leu Lys Leu 
145                 150                 155                 160 


Leu Lys Arg Ala Leu Asp Leu Gly Ala Asp Tyr Ile Gly Leu Ser Phe 
                165                 170                 175     


Val Ile Ser Glu Asn Asp Val Lys Lys Val Lys Glu Phe Val Gly Asp 
            180                 185                 190         


Glu Ala Trp Val Ile Ala Lys Ile Glu Lys Ser Glu Ala Leu Lys Asn 
        195                 200                 205             


Leu Thr Asn Ile Val Asn Glu Ser Asp Gly Ile Met Val Ala Arg Gly 
    210                 215                 220                 


Asp Leu Gly Val Glu Thr Gly Leu Glu Asn Leu Pro Leu Ile Gln Arg 
225                 230                 235                 240 


Arg Ile Val Arg Thr Ser Arg Val Phe Gly Lys Pro Val Ile Leu Ala 
                245                 250                 255     


Thr Gln Val Leu Thr Ser Met Ile Asn Ser Pro Ile Pro Thr Arg Ala 
            260                 265                 270         


Glu Ile Ile Asp Ile Ser Asn Ser Ile Met Gln Gly Val Asp Ser Ile 
        275                 280                 285             


Met Leu Ser Asp Glu Thr Ala Ile Gly Asn Tyr Pro Val Glu Ser Val 
    290                 295                 300                 


Arg Thr Leu His Asn Ile Ile Ser Asn Val Glu Lys Ser Val Lys His 
305                 310                 315                 320 


Arg Pro Ile Gly Pro Leu Asn Ser Glu Ser Asp Ala Ile Ala Leu Ala 
                325                 330                 335     


Ala Val Asn Ala Ser Lys Val Ser Lys Ala Asp Val Ile Val Val Tyr 
            340                 345                 350         


Ser Arg Ser Gly Asn Ser Ile Leu Arg Val Ser Arg Leu Arg Pro Glu 
        355                 360                 365             


Arg Asn Ile Ile Gly Val Ser Pro Asp Pro Arg Leu Ala Lys Lys Phe 
    370                 375                 380                 


Lys Leu Cys Tyr Gly Val Ile Pro Ile Ser Ile Asn Lys Lys Met Gln 
385                 390                 395                 400 


Ser Ile Asp Glu Ile Ile Asp Val Ser Ala Lys Leu Met Gln Glu Lys 
                405                 410                 415     


Ile Lys Asp Leu Lys Phe Lys Lys Ile Val Ile Val Gly Gly Asp Pro 
            420                 425                 430         


Lys Gln Glu Ala Gly Lys Thr Asn Phe Val Ile Val Lys Thr Leu Glu 
        435                 440                 445             


Gln Gln Lys Lys 
    450         


<210>  23
<211>  466
<212>  PRT
<213>  Thermotoga maritima

<400>  23

Met Arg Ser Thr Lys Ile Val Cys Thr Val Gly Pro Arg Thr Asp Ser 
1               5                   10                  15      


Tyr Glu Met Ile Glu Lys Met Ile Asp Leu Gly Val Asn Val Phe Arg 
            20                  25                  30          


Ile Asn Thr Ser His Gly Asp Trp Asn Glu Gln Glu Gln Lys Ile Leu 
        35                  40                  45              


Lys Ile Lys Asp Leu Arg Glu Lys Lys Lys Lys Pro Val Ala Ile Leu 
    50                  55                  60                  


Ile Asp Leu Ala Gly Pro Lys Ile Arg Thr Gly Tyr Leu Glu Lys Glu 
65                  70                  75                  80  


Phe Val Glu Leu Lys Glu Gly Gln Ile Phe Thr Leu Thr Thr Lys Glu 
                85                  90                  95      


Ile Leu Gly Asn Glu His Ile Val Ser Val Asn Leu Ser Ser Leu Pro 
            100                 105                 110         


Lys Asp Val Lys Lys Gly Asp Thr Ile Leu Leu Ser Asp Gly Glu Ile 
        115                 120                 125             


Val Leu Glu Val Ile Glu Thr Thr Asp Thr Glu Val Lys Thr Val Val 
    130                 135                 140                 


Lys Val Gly Gly Lys Ile Thr His Arg Arg Gly Val Asn Val Pro Thr 
145                 150                 155                 160 


Ala Asp Leu Ser Val Glu Ser Ile Thr Asp Arg Asp Arg Glu Phe Ile 
                165                 170                 175     


Lys Leu Gly Thr Leu His Asp Val Glu Phe Phe Ala Leu Ser Phe Val 
            180                 185                 190         


Arg Lys Pro Glu Asp Val Leu Lys Ala Lys Glu Glu Ile Arg Lys His 
        195                 200                 205             


Gly Lys Glu Ile Pro Val Ile Ser Lys Ile Glu Thr Lys Lys Ala Leu 
    210                 215                 220                 


Glu Arg Leu Glu Glu Ile Ile Lys Val Ser Asp Gly Ile Met Val Ala 
225                 230                 235                 240 


Arg Gly Asp Leu Gly Val Glu Ile Pro Ile Glu Glu Val Pro Ile Val 
                245                 250                 255     


Gln Lys Glu Ile Ile Lys Leu Ser Lys Tyr Tyr Ser Lys Pro Val Ile 
            260                 265                 270         


Val Ala Thr Gln Ile Leu Glu Ser Met Ile Glu Asn Pro Phe Pro Thr 
        275                 280                 285             


Arg Ala Glu Val Thr Asp Ile Ala Asn Ala Ile Phe Asp Gly Ala Asp 
    290                 295                 300                 


Ala Leu Leu Leu Thr Ala Glu Thr Ala Val Gly Lys His Pro Leu Glu 
305                 310                 315                 320 


Ala Ile Lys Val Leu Ser Lys Val Ala Lys Glu Ala Glu Lys Lys Leu 
                325                 330                 335     


Glu Phe Phe Arg Thr Ile Glu Tyr Asp Thr Ser Asp Ile Ser Glu Ala 
            340                 345                 350         


Ile Ser His Ala Cys Trp Gln Leu Ser Glu Ser Leu Asn Ala Lys Leu 
        355                 360                 365             


Ile Ile Thr Pro Thr Ile Ser Gly Ser Thr Ala Val Arg Val Ser Lys 
    370                 375                 380                 


Tyr Asn Val Ser Gln Pro Ile Val Ala Leu Thr Pro Glu Glu Lys Thr 
385                 390                 395                 400 


Tyr Tyr Arg Leu Ser Leu Val Arg Lys Val Ile Pro Val Leu Ala Glu 
                405                 410                 415     


Lys Cys Ser Gln Glu Leu Glu Phe Ile Glu Lys Gly Leu Lys Lys Val 
            420                 425                 430         


Glu Glu Met Gly Leu Ala Glu Lys Gly Asp Leu Val Val Leu Thr Ser 
        435                 440                 445             


Gly Val Pro Gly Lys Val Gly Thr Thr Asn Thr Ile Arg Val Leu Lys 
    450                 455                 460                 


Val Asp 
465     


<210>  24
<211>  477
<212>  PRT
<213>  Pyrococcus furiosus

<400>  24

Met Arg Arg Val Lys Leu Pro Ser His Lys Thr Lys Ile Val Ala Thr 
1               5                   10                  15      


Ile Gly Pro Ala Thr Asn Ser Arg Lys Met Ile Lys Gln Leu Ile Lys 
            20                  25                  30          


Ala Gly Met Asn Val Ala Arg Ile Asn Phe Ser His Gly Ser Phe Glu 
        35                  40                  45              


Glu His Ala Arg Val Ile Glu Ile Ile Arg Glu Glu Ala Gln Lys Leu 
    50                  55                  60                  


Asp Arg Arg Val Ala Ile Leu Ala Asp Leu Pro Gly Leu Lys Ile Arg 
65                  70                  75                  80  


Val Gly Glu Ile Lys Gly Gly Tyr Val Glu Leu Lys Arg Gly Glu Lys 
                85                  90                  95      


Val Ile Leu Thr Thr Lys Asp Val Glu Gly Asp Glu Thr Thr Ile Pro 
            100                 105                 110         


Val Asp Tyr Lys Gly Phe Pro Asn Leu Val Ser Lys Gly Asp Ile Ile 
        115                 120                 125             


Tyr Leu Asn Asp Gly Tyr Ile Val Leu Lys Val Glu Asn Val Arg Glu 
    130                 135                 140                 


Asn Glu Val Glu Ala Val Val Leu Ser Gly Gly Lys Leu Phe Ser Arg 
145                 150                 155                 160 


Lys Gly Val Asn Ile Pro Lys Ala Tyr Leu Pro Val Glu Ala Ile Thr 
                165                 170                 175     


Pro Lys Asp Phe Glu Ile Met Lys Phe Ala Ile Glu His Gly Val Asp 
            180                 185                 190         


Ala Ile Gly Leu Ser Phe Val Gly Ser Val Tyr Asp Val Leu Lys Ala 
        195                 200                 205             


Lys Ser Phe Leu Glu Lys Asn Asn Ala Glu Asp Val Phe Val Ile Ala 
    210                 215                 220                 


Lys Ile Glu Arg Pro Asp Ala Val Arg Asn Phe Asp Glu Ile Leu Asn 
225                 230                 235                 240 


Ala Ala Asp Gly Ile Met Ile Ala Arg Gly Asp Leu Gly Val Glu Met 
                245                 250                 255     


Pro Ile Glu Gln Leu Pro Ile Leu Gln Lys Lys Leu Ile Arg Lys Ala 
            260                 265                 270         


Asn Met Glu Gly Lys Pro Val Ile Thr Ala Thr Gln Met Leu Val Ser 
        275                 280                 285             


Met Thr Thr Glu Lys Val Pro Thr Arg Ala Glu Val Thr Asp Val Ala 
    290                 295                 300                 


Asn Ala Ile Leu Asp Gly Thr Asp Ala Val Met Leu Ser Glu Glu Thr 
305                 310                 315                 320 


Ala Ile Gly Lys Phe Pro Ile Glu Thr Val Glu Met Met Gly Lys Ile 
                325                 330                 335     


Ala Lys Val Thr Glu Glu Tyr Arg Glu Ser Phe Gly Leu Ser Arg Ile 
            340                 345                 350         


Arg Glu Phe Met Glu Ile Lys Lys Gly Thr Ile Lys Glu Ala Ile Thr 
        355                 360                 365             


Arg Ser Ile Ile Asp Ala Ile Cys Thr Ile Asp Ile Lys Phe Ile Leu 
    370                 375                 380                 


Thr Pro Thr Arg Thr Gly Arg Thr Ala Arg Leu Ile Ser Arg Phe Lys 
385                 390                 395                 400 


Pro Lys Gln Trp Ile Leu Ala Phe Ser Thr Asn Glu Arg Val Cys Asn 
                405                 410                 415     


Asn Leu Met Phe Ser Tyr Gly Val Tyr Pro Phe Cys Leu Glu Glu Gly 
            420                 425                 430         


Phe Asp Glu Asn Asp Ile Val Arg Leu Ile Lys Gly Leu Gly Leu Val 
        435                 440                 445             


Glu Ser Asp Asp Met Val Leu Met Thr Glu Gly Lys Pro Ile Glu Lys 
    450                 455                 460                 


Thr Val Gly Thr Asn Ser Ile Lys Ile Phe Gln Ile Ala 
465                 470                 475         


<210>  25
<211>  408
<212>  PRT
<213>  Methanosarcina thermophila

<400>  25

Met Lys Val Leu Val Ile Asn Ala Gly Ser Ser Ser Leu Lys Tyr Gln 
1               5                   10                  15      


Leu Ile Asp Met Thr Asn Glu Ser Ala Leu Ala Val Gly Leu Cys Glu 
            20                  25                  30          


Arg Ile Gly Ile Asp Asn Ser Ile Ile Thr Gln Lys Lys Phe Asp Gly 
        35                  40                  45              


Lys Lys Leu Glu Lys Leu Thr Asp Leu Pro Thr His Lys Asp Ala Leu 
    50                  55                  60                  


Glu Glu Val Val Lys Ala Leu Thr Asp Asp Glu Phe Gly Val Ile Lys 
65                  70                  75                  80  


Asp Met Gly Glu Ile Asn Ala Val Gly His Arg Val Val His Gly Gly 
                85                  90                  95      


Glu Lys Phe Thr Thr Ser Ala Leu Tyr Asp Glu Gly Val Glu Lys Ala 
            100                 105                 110         


Ile Lys Asp Cys Phe Glu Leu Ala Pro Leu His Asn Pro Pro Asn Met 
        115                 120                 125             


Met Gly Ile Ser Ala Cys Ala Glu Ile Met Pro Gly Thr Pro Met Val 
    130                 135                 140                 


Ile Val Phe Asp Thr Ala Phe His Gln Thr Met Pro Pro Tyr Ala Tyr 
145                 150                 155                 160 


Met Tyr Ala Leu Pro Tyr Asp Leu Tyr Glu Lys His Gly Val Arg Lys 
                165                 170                 175     


Tyr Gly Phe His Gly Thr Ser His Lys Tyr Val Ala Glu Arg Ala Ala 
            180                 185                 190         


Leu Met Leu Gly Lys Pro Ala Glu Glu Thr Lys Ile Ile Thr Cys His 
        195                 200                 205             


Leu Gly Asn Gly Ser Ser Ile Thr Ala Val Glu Gly Gly Lys Ser Val 
    210                 215                 220                 


Glu Thr Ser Met Gly Phe Thr Pro Leu Glu Gly Leu Ala Met Gly Thr 
225                 230                 235                 240 


Arg Cys Gly Ser Ile Asp Pro Ala Ile Val Pro Phe Leu Met Glu Lys 
                245                 250                 255     


Glu Gly Leu Thr Thr Arg Glu Ile Asp Thr Leu Met Asn Lys Lys Ser 
            260                 265                 270         


Gly Val Leu Gly Val Ser Gly Leu Ser Asn Asp Phe Arg Asp Leu Asp 
        275                 280                 285             


Glu Ala Ala Ser Lys Gly Asn Arg Lys Ala Glu Leu Ala Leu Glu Ile 
    290                 295                 300                 


Phe Ala Tyr Lys Val Lys Lys Phe Ile Gly Glu Tyr Ser Ala Val Leu 
305                 310                 315                 320 


Asn Gly Ala Asp Ala Val Val Phe Thr Ala Gly Ile Gly Glu Asn Ser 
                325                 330                 335     


Ala Ser Ile Arg Lys Arg Ile Leu Thr Gly Leu Asp Gly Ile Gly Ile 
            340                 345                 350         


Lys Ile Asp Asp Glu Lys Asn Lys Ile Arg Gly Gln Glu Ile Asp Ile 
        355                 360                 365             


Ser Thr Pro Asp Ala Lys Val Arg Val Phe Val Ile Pro Thr Asn Glu 
    370                 375                 380                 


Glu Leu Ala Ile Ala Arg Glu Thr Lys Glu Ile Val Glu Thr Glu Val 
385                 390                 395                 400 


Lys Leu Arg Ser Ser Ile Pro Val 
                405             


<210>  26
<211>  585
<212>  DNA
<213>  Sulfolobus acidocaldarius

<400>  26
atgaagattg gtattgtaac tggaattcct ggtgtaggga aaagtactgt cttggctaaa     60

gttaaagaga tattggataa tcaaggtata aataacaaga tcataaatta tggagatttt    120

atgttagcaa cagcattaaa attaggctat gctaaagata gagacgaaat gagaaaatta    180

tctgtagaaa agcagaagaa attgcagatt gatgcggcta aaggtatagc tgaagaggca    240

agagcaggtg gagaaggata tctgttcata gatacgcatg ctgtgatacg tacaccctct    300

ggatatttac ctggtttacc gtcatatgta attacagaaa taaatccgtc tgttatcttt    360

ttactggaag ctgatcctaa gataatatta tcaaggcaaa agagagatac aacaaggaat    420

agaaatgatt atagtgacga atcagttata ttagaaacca taaacttcgc tagatatgca    480

gctactgctt ctgcagtatt agccggttct actgttaagg taattgtaaa cgtggaagga    540

gatcctagta tagcagctaa tgagataata aggtctatga agtaa                    585


<210>  27
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
atgaaaatcg gtatcgttac cggtatcccg ggtgttggta aatctaccgt tctggctaaa     60

gttaaagaaa tcctggacaa ccagggtatc aacaacaaaa tcatcaacta cggtgacttc    120

atgctggcta ccgctctgaa actgggttac gctaaagacc gtgacgaaat gcgtaaactg    180

tctgttgaaa aacagaaaaa actgcagatc gacgctgcta aaggtatcgc tgaagaagct    240

cgtgctggtg gtgaaggtta cctgttcatc gacacccacg ctgttatccg taccccgtct    300

ggttacctgc cgggtctgcc gtcttacgtt atcaccgaaa tcaacccgtc tgttatcttc    360

ctgctggaag ctgacccgaa aatcatcctg tctcgtcaga aacgtgacac cacccgtaac    420

cgtaacgact actctgacga atctgttatc ctggaaacca tcaacttcgc tcgttacgct    480

gctaccgctt ctgctgttct ggctggttct accgttaaag ttatcgttaa cgttgaaggt    540

gacccgtcta tcgctgctaa cgaaatcatc cgttctatga aatag                    585


<210>  28
<211>  663
<212>  DNA
<213>  Thermotoga maritima

<400>  28
atgatggcgt accttgtctt tctaggacct ccaggtgcag gaaaaggaac ctacgcaaag     60

agattgcagg aaataacggg gattcctcat atatccaccg gtgacatttt cagggacatt    120

gtaaaaaaag agaacgacga gcttgggaaa aagataaaag agatcatgga aaggggagaa    180

ctcgttccgg acgaactcgt gaacgaggtt gtgaaaagaa gactctcaga aaaagattgt    240

gaaagaggat tcatactgga cggctatcca agaaccgttg ctcaggcgga attcctcgac    300

ggctttttga aaactcaaaa caaagagctc acggctgctg tactctttga agttcctgag    360

gaagtggtcg ttcagaggct cacggccaga aggatctgcc cgaaatgtgg aagaatttac    420

aatttgattt cgctccctcc aaaagaagac gaactgtgcg atgattgtaa agtgaagctc    480

gttcagagag aagacgacaa agaagaaaca gtgagacaca gatacaaggt ttatctcgaa    540

aagacacagc cagtgattga ttactacgat aaaaagggca ttctcaaacg agtggatggt    600

accataggaa tagacaacgt gatcgctgaa gtgttaaaga taatagggtg gagtgataaa    660

tga                                                                  663


<210>  29
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
atgatggcct atctggtttt tcttggtcca ccgggggcag gcaaaggtac atatgcgaaa     60

cgtttacagg aaatcaccgg catcccgcac attagcacgg gcgacatttt tcgtgatatt    120

gtcaaaaagg aaaatgacga attaggtaag aaaattaaag aaattatgga gcgcggcgag    180

ttggtgccgg acgaactggt gaatgaagtt gtcaaacgtc ggctgtctga aaaggattgc    240

gaacgtggct ttattttgga cggttacccg cgtacagtag ctcaggcaga gtttctcgac    300

ggcttcctga agactcagaa taaggagtta acggctgcgg tcctgttcga ggtgcctgaa    360

gaggtggtcg ttcagcgtct gaccgcgcgg cgtatctgcc cgaagtgtgg tcgtatttac    420

aacctgattt cacttcctcc aaaagaagat gaactgtgtg atgactgcaa agtaaaactg    480

gtgcaacgcg aagatgataa agaggaaact gtgcgccatc gctacaaagt atatctggaa    540

aaaacccaac cggttatcga ttattatgat aaaaaaggca ttttgaaacg cgttgatggg    600

accatcggca tcgataacgt gattgccgaa gttctcaaaa tcattgggtg gagtgataaa    660


<210>  30
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
atgaacctga ttttcctggg tccgcctggg gcaggcaaag gcacccaggc gaaacgtgtg     60

tctgaaaagt acggtatccc gcagattagt accggcgata tgctgcgtga agcggttgct    120

aagggtacgg aactggggaa aaaggcgaaa gaatatatgg acaaagggga acttgttccg    180

gatgaagtag ttattggaat cgtgaaagaa cgcctccagc aaccggattg tgagaagggc    240

tttattctgg acggttttcc gcgtacgtta gcacaagccg aagctctgga cgaaatgtta    300

aaagaattga ataagaaaat tgacgccgta atcaacgtgg tcgtaccgga agaggaagtt    360

gtcaagcgta ttacctatcg tcgcacttgc cgcaattgcg gcgccgtgta ccatctcatt    420

tatgcacctc caaaagagga taataaatgt gataaatgcg gcggtgagct ttatcagcgt    480

gatgacgata aagaagagac agtccgcgag cgttaccgtg tgtataaaca gaacacagag    540

ccattgatcg attattaccg taaaaaggga atcctgtatg atgtggatgg tactaaagac    600

atcgaaggag tttggaaaga aattgaggcg attctggaaa aaattaaaag c             651


<210>  31
<211>  194
<212>  PRT
<213>  Sulfolobus acidocaldarius

<400>  31

Met Lys Ile Gly Ile Val Thr Gly Ile Pro Gly Val Gly Lys Ser Thr 
1               5                   10                  15      


Val Leu Ala Lys Val Lys Glu Ile Leu Asp Asn Gln Gly Ile Asn Asn 
            20                  25                  30          


Lys Ile Ile Asn Tyr Gly Asp Phe Met Leu Ala Thr Ala Leu Lys Leu 
        35                  40                  45              


Gly Tyr Ala Lys Asp Arg Asp Glu Met Arg Lys Leu Ser Val Glu Lys 
    50                  55                  60                  


Gln Lys Lys Leu Gln Ile Asp Ala Ala Lys Gly Ile Ala Glu Glu Ala 
65                  70                  75                  80  


Arg Ala Gly Gly Glu Gly Tyr Leu Phe Ile Asp Thr His Ala Val Ile 
                85                  90                  95      


Arg Thr Pro Ser Gly Tyr Leu Pro Gly Leu Pro Ser Tyr Val Ile Thr 
            100                 105                 110         


Glu Ile Asn Pro Ser Val Ile Phe Leu Leu Glu Ala Asp Pro Lys Ile 
        115                 120                 125             


Ile Leu Ser Arg Gln Lys Arg Asp Thr Thr Arg Asn Arg Asn Asp Tyr 
    130                 135                 140                 


Ser Asp Glu Ser Val Ile Leu Glu Thr Ile Asn Phe Ala Arg Tyr Ala 
145                 150                 155                 160 


Ala Thr Ala Ser Ala Val Leu Ala Gly Ser Thr Val Lys Val Ile Val 
                165                 170                 175     


Asn Val Glu Gly Asp Pro Ser Ile Ala Ala Asn Glu Ile Ile Arg Ser 
            180                 185                 190         


Met Lys 
        


<210>  32
<211>  220
<212>  PRT
<213>  Thermotoga maritima

<400>  32

Met Met Ala Tyr Leu Val Phe Leu Gly Pro Pro Gly Ala Gly Lys Gly 
1               5                   10                  15      


Thr Tyr Ala Lys Arg Leu Gln Glu Ile Thr Gly Ile Pro His Ile Ser 
            20                  25                  30          


Thr Gly Asp Ile Phe Arg Asp Ile Val Lys Lys Glu Asn Asp Glu Leu 
        35                  40                  45              


Gly Lys Lys Ile Lys Glu Ile Met Glu Arg Gly Glu Leu Val Pro Asp 
    50                  55                  60                  


Glu Leu Val Asn Glu Val Val Lys Arg Arg Leu Ser Glu Lys Asp Cys 
65                  70                  75                  80  


Glu Arg Gly Phe Ile Leu Asp Gly Tyr Pro Arg Thr Val Ala Gln Ala 
                85                  90                  95      


Glu Phe Leu Asp Gly Phe Leu Lys Thr Gln Asn Lys Glu Leu Thr Ala 
            100                 105                 110         


Ala Val Leu Phe Glu Val Pro Glu Glu Val Val Val Gln Arg Leu Thr 
        115                 120                 125             


Ala Arg Arg Ile Cys Pro Lys Cys Gly Arg Ile Tyr Asn Leu Ile Ser 
    130                 135                 140                 


Leu Pro Pro Lys Glu Asp Glu Leu Cys Asp Asp Cys Lys Val Lys Leu 
145                 150                 155                 160 


Val Gln Arg Glu Asp Asp Lys Glu Glu Thr Val Arg His Arg Tyr Lys 
                165                 170                 175     


Val Tyr Leu Glu Lys Thr Gln Pro Val Ile Asp Tyr Tyr Asp Lys Lys 
            180                 185                 190         


Gly Ile Leu Lys Arg Val Asp Gly Thr Ile Gly Ile Asp Asn Val Ile 
        195                 200                 205             


Ala Glu Val Leu Lys Ile Ile Gly Trp Ser Asp Lys 
    210                 215                 220 


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transglutaminase substrate

<400>  33

Met Asn Gln Glu Gln Val Ser Pro Leu Gly Gly 
1               5                   10      


<210>  34
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of thermostable adenylate kinase from Sulfolobus
       acidcaldarius fused at the N-terminus with a transglutaminase 
       (Factor XIII) substrate sequence

<400>  34

Met Asn Gln Glu Gln Val Ser Pro Leu Gly Gly Lys Ile Gly Ile Val 
1               5                   10                  15      


Thr Gly Ile Pro Gly Val Gly Lys Ser Thr Val Leu Ala Lys Val Lys 
            20                  25                  30          


Glu Ile Leu Asp Asn Gln Gly Ile Asn Asn Lys Ile Ile Asn Tyr Gly 
        35                  40                  45              


Asp Phe Met Leu Ala Thr Ala Leu Lys Leu Gly Tyr Ala Lys Asp Arg 
    50                  55                  60                  


Asp Glu Met Arg Lys Leu Ser Val Glu Lys Gln Lys Lys Leu Gln Ile 
65                  70                  75                  80  


Asp Ala Ala Lys Gly Ile Ala Glu Glu Ala Arg Ala Gly Gly Glu Gly 
                85                  90                  95      


Tyr Leu Phe Ile Asp Thr His Ala Val Ile Arg Thr Pro Ser Gly Tyr 
            100                 105                 110         


Leu Pro Gly Leu Pro Ser Tyr Val Ile Thr Glu Ile Asn Pro Ser Val 
        115                 120                 125             


Ile Phe Leu Leu Glu Ala Asp Pro Lys Ile Ile Leu Ser Arg Gln Lys 
    130                 135                 140                 


Arg Asp Thr Thr Arg Asn Arg Asn Asp Tyr Ser Asp Glu Ser Val Ile 
145                 150                 155                 160 


Leu Glu Thr Ile Asn Phe Ala Arg Tyr Ala Ala Thr Ala Ser Ala Val 
                165                 170                 175     


Leu Ala Gly Ser Thr Val Lys Val Ile Val Asn Val Glu Gly Asp Pro 
            180                 185                 190         


Ser Ile Ala Ala Asn Glu Ile Ile Arg Ser Met Lys 
        195                 200                 


<210>  35
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of thermostable adenylate kinase from Sulfolobus
       acidcaldarius fused at the C-terminus with a transglutaminase 
       (factor VIII) substrate sequence

<400>  35

Met Lys Ile Gly Ile Val Thr Gly Ile Pro Gly Val Gly Lys Ser Thr 
1               5                   10                  15      


Val Leu Ala Lys Val Lys Glu Ile Leu Asp Asn Gln Gly Ile Asn Asn 
            20                  25                  30          


Lys Ile Ile Asn Tyr Gly Asp Phe Met Leu Ala Thr Ala Leu Lys Leu 
        35                  40                  45              


Gly Tyr Ala Lys Asp Arg Asp Glu Met Arg Lys Leu Ser Val Glu Lys 
    50                  55                  60                  


Gln Lys Lys Leu Gln Ile Asp Ala Ala Lys Gly Ile Ala Glu Glu Ala 
65                  70                  75                  80  


Arg Ala Gly Gly Glu Gly Tyr Leu Phe Ile Asp Thr His Ala Val Ile 
                85                  90                  95      


Arg Thr Pro Ser Gly Tyr Leu Pro Gly Leu Pro Ser Tyr Val Ile Thr 
            100                 105                 110         


Glu Ile Asn Pro Ser Val Ile Phe Leu Leu Glu Ala Asp Pro Lys Ile 
        115                 120                 125             


Ile Leu Ser Arg Gln Lys Arg Asp Thr Thr Arg Asn Arg Asn Asp Tyr 
    130                 135                 140                 


Ser Asp Glu Ser Val Ile Leu Glu Thr Ile Asn Phe Ala Arg Tyr Ala 
145                 150                 155                 160 


Ala Thr Ala Ser Ala Val Leu Ala Gly Ser Thr Val Lys Val Ile Val 
                165                 170                 175     


Asn Val Glu Gly Asp Pro Ser Ile Ala Ala Asn Glu Ile Ile Arg Ser 
            180                 185                 190         


Met Lys Gly Gly Asn Gln Glu Gln Val Ser Pro Leu 
        195                 200                 


<210>  36
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of thermostable adenylate kinase from Sulfolobus
       acidcaldarius fused at the N-terminus and C-terminus with a 
       transglutaminase (Factor XIII)  substrate sequence

<400>  36

Met Asn Gln Glu Gln Val Ser Pro Leu Gly Gly Lys Ile Gly Ile Val 
1               5                   10                  15      


Thr Gly Ile Pro Gly Val Gly Lys Ser Thr Val Leu Ala Lys Val Lys 
            20                  25                  30          


Glu Ile Leu Asp Asn Gln Gly Ile Asn Asn Lys Ile Ile Asn Tyr Gly 
        35                  40                  45              


Asp Phe Met Leu Ala Thr Ala Leu Lys Leu Gly Tyr Ala Lys Asp Arg 
    50                  55                  60                  


Asp Glu Met Arg Lys Leu Ser Val Glu Lys Gln Lys Lys Leu Gln Ile 
65                  70                  75                  80  


Asp Ala Ala Lys Gly Ile Ala Glu Glu Ala Arg Ala Gly Gly Glu Gly 
                85                  90                  95      


Tyr Leu Phe Ile Asp Thr His Ala Val Ile Arg Thr Pro Ser Gly Tyr 
            100                 105                 110         


Leu Pro Gly Leu Pro Ser Tyr Val Ile Thr Glu Ile Asn Pro Ser Val 
        115                 120                 125             


Ile Phe Leu Leu Glu Ala Asp Pro Lys Ile Ile Leu Ser Arg Gln Lys 
    130                 135                 140                 


Arg Asp Thr Thr Arg Asn Arg Asn Asp Tyr Ser Asp Glu Ser Val Ile 
145                 150                 155                 160 


Leu Glu Thr Ile Asn Phe Ala Arg Tyr Ala Ala Thr Ala Ser Ala Val 
                165                 170                 175     


Leu Ala Gly Ser Thr Val Lys Val Ile Val Asn Val Glu Gly Asp Pro 
            180                 185                 190         


Ser Ile Ala Ala Asn Glu Ile Ile Arg Ser Met Lys Gly Gly Asn Gln 
        195                 200                 205             


Glu Gln Val Ser Pro Leu 
    210                 


<210>  37
<211>  704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of transglutaminase (Factor XIII) substrate sequence
       fused to the 5' end of adenylate kinase from Thermotoga maritima.

<400>  37
atgaatcaag aacaagtcag cccgctgggc ggcatcatcg cctatctggt ttttcttggt     60

ccaccggggg caggcaaagg tacctatgcg aaacgtttac aggaaatcac cggcatcccg    120

cacattagca cgggcgacat ttttcgtgat attgtcaaaa aggaaaatga cgaattaggt    180

aagaaaatta aagaaattat ggagcgcggc gagttggtgc cggacgaact ggtgaatgaa    240

gttgtcaaac gtcggctgtc tgaaaaggat tgcgaacgtg gctttatttt ggacggttac    300

ccgcgtacag tagctcaggc agagtttctc gacggcttcc tgaagactca gaataaggag    360

ttaacggctg cggtcctgtt cgaggtgcct gaagaggtgg tcgttcagcg tctgaccgcg    420

cggcgtatct gcccgaagtg tggtcgtatt tacaacctga tttcacttcc tccaaaagaa    480

gatgaactgt gtgatgactg caaagtaaaa ctggtgcaac gcgaagatga taaagaggaa    540

actgtgcgcc atcgctacaa agtatatctg gaaaaaaccc aaccggttat cgattattat    600

gataaaaaag gcattttgaa acgcgttgat gggaccatcg gcatcgataa cgtgattgcc    660

gaagttctca aaatcattgg gtggagtgat aaataggtcg acgc                     704


<210>  38
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of adenylate kinase from Thermotoga maritime 
       fused at the N-terminal with a transglutaminase (Factor XIII) 
       substrate sequence.

<400>  38

Met Asn Gln Glu Gln Val Ser Pro Leu Gly Gly Ile Ile Ala Tyr Leu 
1               5                   10                  15      


Val Phe Leu Gly Pro Pro Gly Ala Gly Lys Gly Thr Tyr Ala Lys Arg 
            20                  25                  30          


Leu Gln Glu Ile Thr Gly Ile Pro His Ile Ser Thr Gly Asp Ile Phe 
        35                  40                  45              


Arg Asp Ile Val Lys Lys Glu Asn Asp Glu Leu Gly Lys Lys Ile Lys 
    50                  55                  60                  


Glu Ile Met Glu Arg Gly Glu Leu Val Pro Asp Glu Leu Val Asn Glu 
65                  70                  75                  80  


Val Val Lys Arg Arg Leu Ser Glu Lys Asp Cys Glu Arg Gly Phe Ile 
                85                  90                  95      


Leu Asp Gly Tyr Pro Arg Thr Val Ala Gln Ala Glu Phe Leu Asp Gly 
            100                 105                 110         


Phe Leu Lys Thr Gln Asn Lys Glu Leu Thr Ala Ala Val Leu Phe Glu 
        115                 120                 125             


Val Pro Glu Glu Val Val Val Gln Arg Leu Thr Ala Arg Arg Ile Cys 
    130                 135                 140                 


Pro Lys Cys Gly Arg Ile Tyr Asn Leu Ile Ser Leu Pro Pro Lys Glu 
145                 150                 155                 160 


Asp Glu Leu Cys Asp Asp Cys Lys Val Lys Leu Val Gln Arg Glu Asp 
                165                 170                 175     


Asp Lys Glu Glu Thr Val Arg His Arg Tyr Lys Val Tyr Leu Glu Lys 
            180                 185                 190         


Thr Gln Pro Val Ile Asp Tyr Tyr Asp Lys Lys Gly Ile Leu Lys Arg 
        195                 200                 205             


Val Asp Gly Thr Ile Gly Ile Asp Asn Val Ile Ala Glu Val Leu Lys 
    210                 215                 220                 


Ile Ile Gly Trp Ser Asp Lys 
225                 230     


<210>  39
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of transglutaminase (Factor XIII) substrate sequence
       fused to the 3' end of adenylate kinase from Thermotoga maritima.

<400>  39
atgatggcct atctggtttt tcttggtcca ccgggggcag gcaaaggtac ctatgcgaaa     60

cgtttacagg aaatcaccgg catcccgcac attagcacgg gcgacatttt tcgtgatatt    120

gtcaaaaagg aaaatgacga attaggtaag aaaattaaag aaattatgga gcgcggcgag    180

ttggtgccgg acgaactggt gaatgaagtt gtcaaacgtc ggctgtctga aaaggattgc    240

gaacgtggct ttattttgga cggttacccg cgtacagtag ctcaggcaga gtttctcgac    300

ggcttcctga agactcagaa taaggagtta acggctgcgg tcctgttcga ggtgcctgaa    360

gaggtggtcg ttcagcgtct gaccgcgcgg cgtatctgcc cgaagtgtgg tcgtatttac    420

aacctgattt cacttcctcc aaaagaagat gaactgtgtg atgactgcaa agtaaaactg    480

gtgcaacgcg aagatgataa agaggaaact gtgcgccatc gctacaaagt atatctggaa    540

aaaacccaac cggttatcga ttattatgat aaaaaaggca ttttgaaacg cgttgatggg    600

accatcggca tcgataacgt gattgccgaa gttctcaaaa tcattgggtg gagtgataaa    660

ctgggcggca atcaagaaca agtcagcccg ctgtaa                              696


<210>  40
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of adenylate kinase from Thermotoga maritime 
       fused at the C-terminal with a transglutaminase (Factor XIII) 
       substrate sequence.

<400>  40

Met Met Ala Tyr Leu Val Phe Leu Gly Pro Pro Gly Ala Gly Lys Gly 
1               5                   10                  15      


Thr Tyr Ala Lys Arg Leu Gln Glu Ile Thr Gly Ile Pro His Ile Ser 
            20                  25                  30          


Thr Gly Asp Ile Phe Arg Asp Ile Val Lys Lys Glu Asn Asp Glu Leu 
        35                  40                  45              


Gly Lys Lys Ile Lys Glu Ile Met Glu Arg Gly Glu Leu Val Pro Asp 
    50                  55                  60                  


Glu Leu Val Asn Glu Val Val Lys Arg Arg Leu Ser Glu Lys Asp Cys 
65                  70                  75                  80  


Glu Arg Gly Phe Ile Leu Asp Gly Tyr Pro Arg Thr Val Ala Gln Ala 
                85                  90                  95      


Glu Phe Leu Asp Gly Phe Leu Lys Thr Gln Asn Lys Glu Leu Thr Ala 
            100                 105                 110         


Ala Val Leu Phe Glu Val Pro Glu Glu Val Val Val Gln Arg Leu Thr 
        115                 120                 125             


Ala Arg Arg Ile Cys Pro Lys Cys Gly Arg Ile Tyr Asn Leu Ile Ser 
    130                 135                 140                 


Leu Pro Pro Lys Glu Asp Glu Leu Cys Asp Asp Cys Lys Val Lys Leu 
145                 150                 155                 160 


Val Gln Arg Glu Asp Asp Lys Glu Glu Thr Val Arg His Arg Tyr Lys 
                165                 170                 175     


Val Tyr Leu Glu Lys Thr Gln Pro Val Ile Asp Tyr Tyr Asp Lys Lys 
            180                 185                 190         


Gly Ile Leu Lys Arg Val Asp Gly Thr Ile Gly Ile Asp Asn Val Ile 
        195                 200                 205             


Ala Glu Val Leu Lys Ile Ile Gly Trp Ser Asp Lys Leu Gly Gly Asn 
    210                 215                 220                 


Gln Glu Gln Val Ser Pro Leu 
225                 230     


<210>  41
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of transglutaminase (Factor XIII) substrate sequence
       fused to both the 5' and 3' ends of adenylate kinase from 
       Thermotoga maritima.

<400>  41
atgaatcaag aacaagtcag cccgctgggc ggcatcatcg cctatctggt ttttcttggt     60

ccaccggggg caggcaaagg tacctatgcg aaacgtttac aggaaatcac cggcatcccg    120

cacattagca cgggcgacat ttttcgtgat attgtcaaaa aggaaaatga cgaattaggt    180

aagaaaatta aagaaattat ggagcgcggc gagttggtgc cggacgaact ggtgaatgaa    240

gttgtcaaac gtcggctgtc tgaaaaggat tgcgaacgtg gctttatttt ggacggttac    300

ccgcgtacag tagctcaggc agagtttctc gacggcttcc tgaagactca gaataaggag    360

ttaacggctg cggtcctgtt cgaggtgcct gaagaggtgg tcgttcagcg tctgaccgcg    420

cggcgtatct gcccgaagtg tggtcgtatt tacaacctga tttcacttcc tccaaaagaa    480

gatgaactgt gtgatgactg caaagtaaaa ctggtgcaac gcgaagatga taaagaggaa    540

actgtgcgcc atcgctacaa agtatatctg gaaaaaaccc aaccggttat cgattattat    600

gataaaaaag gcattttgaa acgcgttgat gggaccatcg gcatcgataa cgtgattgcc    660

gaagttctca aaatcattgg gtggagtgat aaactgggcg gcaatcaaga acaagtcagc    720

ccgctgtaa                                                            729


<210>  42
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of adenylate kinase from Thermotoga maritime 
       fused at the N- and C-terminal with a transglutaminase (Factor 
       XIII) substrate sequence.

<400>  42

Met Asn Gln Glu Gln Val Ser Pro Leu Gly Gly Ile Ile Ala Tyr Leu 
1               5                   10                  15      


Val Phe Leu Gly Pro Pro Gly Ala Gly Lys Gly Thr Tyr Ala Lys Arg 
            20                  25                  30          


Leu Gln Glu Ile Thr Gly Ile Pro His Ile Ser Thr Gly Asp Ile Phe 
        35                  40                  45              


Arg Asp Ile Val Lys Lys Glu Asn Asp Glu Leu Gly Lys Lys Ile Lys 
    50                  55                  60                  


Glu Ile Met Glu Arg Gly Glu Leu Val Pro Asp Glu Leu Val Asn Glu 
65                  70                  75                  80  


Val Val Lys Arg Arg Leu Ser Glu Lys Asp Cys Glu Arg Gly Phe Ile 
                85                  90                  95      


Leu Asp Gly Tyr Pro Arg Thr Val Ala Gln Ala Glu Phe Leu Asp Gly 
            100                 105                 110         


Phe Leu Lys Thr Gln Asn Lys Glu Leu Thr Ala Ala Val Leu Phe Glu 
        115                 120                 125             


Val Pro Glu Glu Val Val Val Gln Arg Leu Thr Ala Arg Arg Ile Cys 
    130                 135                 140                 


Pro Lys Cys Gly Arg Ile Tyr Asn Leu Ile Ser Leu Pro Pro Lys Glu 
145                 150                 155                 160 


Asp Glu Leu Cys Asp Asp Cys Lys Val Lys Leu Val Gln Arg Glu Asp 
                165                 170                 175     


Asp Lys Glu Glu Thr Val Arg His Arg Tyr Lys Val Tyr Leu Glu Lys 
            180                 185                 190         


Thr Gln Pro Val Ile Asp Tyr Tyr Asp Lys Lys Gly Ile Leu Lys Arg 
        195                 200                 205             


Val Asp Gly Thr Ile Gly Ile Asp Asn Val Ile Ala Glu Val Leu Lys 
    210                 215                 220                 


Ile Ile Gly Trp Ser Asp Lys Leu Gly Gly Asn Gln Glu Gln Val Ser 
225                 230                 235                 240 


Pro Leu 
        


<210>  43
<211>  1288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of complete Sup35 gene construct from Saccharomyces 
       cerevisiae

<400>  43
gattcaaacc aaggcaacaa tcagcaaaac taccagcaat acagccagaa cggtaaccaa     60

caacaaggta acaacagata ccaaggttat caagcttaca atgctcaagc ccaacctggg    120

ggtgggtact accaaaatta ccaaggttat tctgggtacc aacaaggtgg ctatcaacag    180

tacaatcccg acgccggtta ccagcaacag tataatcctc aaggaggcta tcaacagtac    240

aatcctcaag gcggttatca gcaccaattc aatccacaag gtggccgtgg aaattacaaa    300

aacttcaact acaataacaa tttgcaagga tatcaagctg gtttccaacc acagtctcaa    360

ggtatgtctt tgaacgactt tcaaaagcaa caaaagcagg ccgctcccaa accaaagaag    420

actttgaagc ttgtctccag ttcctgtatc aagttggcca atgctaccaa gaaggttgac    480

acaaaacctg ccgaatctga taagaaagag gaagagaagt ctgctgaaac caaagaacca    540

actaaagagc caacaaaggt cgaagaacca gttaaaaagg aggagaaacc agtccagact    600

gaagaaaaga cggaggaaaa atcggaactt ccaaaggtag aagaccttaa aatctctgaa    660

tcaacacata ataccaacaa tgccaatgtt accagtgctg atgccttgat caaggaacag    720

gaagaagaag tggatgacga agttgttaac gatatgtttg gtggtaaaga tcacgtttct    780

ttaattttca tgggtcatgt tgatgccggt aaatctacta tgggtggtaa tctactatac    840

ttgactggct ctgtggataa gagaactatt gagaaatatg aaagagaagc caaggatgca    900

ggcagacaag gttggtactt gtcatgggtc atggatacca acaaagaaga aagaaatgat    960

ggtaagacta tcgaagttgg taaggcctac tttgaaactg aaaaaaggcg ttataccata   1020

ttggatgctc ctggtcataa aatgtacgtt tccgagatga tcggtggtgc ttctcaagct   1080

gatgttggtg ttttggtcat ttccgccaga aagggtgagt acgaaaccgg ttttgagaga   1140

ggtggtcaaa ctcgtgaaca cgccctattg gccaagaccc aaggtgttaa taagatggtt   1200

gtcgtcgtaa ataagatgga tgacccaacc gttaactggt ctaaggaacg ttacgaccaa   1260

tgtgtgagta atgtcagcaa tttcttga                                      1288


<210>  44
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of complete Sup35 from Saccharomyces cerevisiae

<400>  44

Asp Ser Asn Gln Gly Asn Asn Gln Gln Asn Tyr Gln Gln Tyr Ser Gln 
1               5                   10                  15      


Asn Gly Asn Gln Gln Gln Gly Asn Asn Arg Tyr Gln Gly Tyr Gln Ala 
            20                  25                  30          


Tyr Asn Ala Gln Ala Gln Pro Gly Gly Gly Tyr Tyr Gln Asn Tyr Gln 
        35                  40                  45              


Gly Tyr Ser Gly Tyr Gln Gln Gly Gly Tyr Gln Gln Tyr Asn Pro Asp 
    50                  55                  60                  


Ala Gly Tyr Gln Gln Gln Tyr Asn Pro Gln Gly Gly Tyr Gln Gln Tyr 
65                  70                  75                  80  


Asn Pro Gln Gly Gly Tyr Gln His Gln Phe Asn Pro Gln Gly Gly Arg 
                85                  90                  95      


Gly Asn Tyr Lys Asn Phe Asn Tyr Asn Asn Asn Leu Gln Gly Tyr Gln 
            100                 105                 110         


Ala Gly Phe Gln Pro Gln Ser Gln Gly Met Ser Leu Asn Asp Phe Gln 
        115                 120                 125             


Lys Gln Gln Lys Gln Ala Ala Pro Lys Pro Lys Lys Thr Leu Lys Leu 
    130                 135                 140                 


Val Ser Ser Ser Cys Ile Lys Leu Ala Asn Ala Thr Lys Lys Val Asp 
145                 150                 155                 160 


Thr Lys Pro Ala Glu Ser Asp Lys Lys Glu Glu Glu Lys Ser Ala Glu 
                165                 170                 175     


Thr Lys Glu Pro Thr Lys Glu Pro Thr Lys Val Glu Glu Pro Val Lys 
            180                 185                 190         


Lys Glu Glu Lys Pro Val Gln Thr Glu Glu Lys Thr Glu Glu Lys Ser 
        195                 200                 205             


Glu Leu Pro Lys Val Glu Asp Leu Lys Ile Ser Glu Ser Thr His Asn 
    210                 215                 220                 


Thr Asn Asn Ala Asn Val Thr Ser Ala Asp Ala Leu Ile Lys Glu Gln 
225                 230                 235                 240 


Glu Glu Glu Val Asp Asp Glu Val Val Asn Asp Met Phe Gly Gly Lys 
                245                 250                 255     


Asp His Val Ser Leu Ile Phe Met Gly His Val Asp Ala Gly Lys Ser 
            260                 265                 270         


Thr Met Gly Gly Asn Leu Leu Tyr Leu Thr Gly Ser Val Asp Lys Arg 
        275                 280                 285             


Thr Ile Glu Lys Tyr Glu Arg Glu Ala Lys Asp Ala Gly Arg Gln Gly 
    290                 295                 300                 


Trp Tyr Leu Ser Trp Val Met Asp Thr Asn Lys Glu Glu Arg Asn Asp 
305                 310                 315                 320 


Gly Lys Thr Ile Glu Val Gly Lys Ala Tyr Phe Glu Thr Glu Lys Arg 
                325                 330                 335     


Arg Tyr Thr Ile Leu Asp Ala Pro Gly His Lys Met Tyr Val Ser Glu 
            340                 345                 350         


Met Ile Gly Gly Ala Ser Gln Ala Asp Val Gly Val Leu Val Ile Ser 
        355                 360                 365             


Ala Arg Lys Gly Glu Tyr Glu Thr Gly Phe Glu Arg Gly Gly Gln Thr 
    370                 375                 380                 


Arg Glu His Ala Leu Leu Ala Lys Thr Gln Gly Val Asn Lys Met Val 
385                 390                 395                 400 


Val Val Val Asn Lys Met Asp Asp Pro Thr Val Asn Trp Ser Lys Glu 
                405                 410                 415     


Arg Tyr Asp Gln Cys Val Ser Asn Val Ser Asn Phe Leu 
            420                 425                 


<210>  45
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of sup35N (N-terminal domain) codon-biased for 
       optimal expression in E. coli

<400>  45
atggactcta accagggtaa caaccagcag aactaccagc agtactctca gaacggtaac     60

cagcagcagg gtaacaaccg ttaccagggt taccaggctt acaacgctca ggctcagccg    120

ggtggtggtt actaccagaa ctaccagggt tactccggat atcaacaggg tggttaccaa    180

caatataatc cagacgctgg ttaccagcag cagtacaacc cgcagggtgg ttaccagcag    240

tacaacccgc aaggcggata tcaacaccag ttcaatccgc agggtggtcg tggtaactac    300

aaaaacttca actacaacaa caacctgcag ggttaccagg ctggttaa                 348


<210>  46
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of sup35N (N-terminal domain)

<400>  46

Met Asp Ser Asn Gln Gly Asn Asn Gln Gln Asn Tyr Gln Gln Tyr Ser 
1               5                   10                  15      


Gln Asn Gly Asn Gln Gln Gln Gly Asn Asn Arg Tyr Gln Gly Tyr Gln 
            20                  25                  30          


Ala Tyr Asn Ala Gln Ala Gln Pro Gly Gly Gly Tyr Tyr Gln Asn Tyr 
        35                  40                  45              


Gln Gly Tyr Ser Gly Tyr Gln Gln Gly Gly Tyr Gln Gln Tyr Asn Pro 
    50                  55                  60                  


Asp Ala Gly Tyr Gln Gln Gln Tyr Asn Pro Gln Gly Gly Tyr Gln Gln 
65                  70                  75                  80  


Tyr Asn Pro Gln Gly Gly Tyr Gln His Gln Phe Asn Pro Gln Gly Gly 
                85                  90                  95      


Arg Gly Asn Tyr Lys Asn Phe Asn Tyr Asn Asn Asn Leu Gln Gly Tyr 
            100                 105                 110         


Gln Ala Gly 
        115 


<210>  47
<211>  941
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of E-coli codon biased Adenylate kinase from 
       Sulfolobus acidcaldarius fused at the N-terminus with Sup35 
       N-terminal domain from Saccharomyces cerevisiae

<400>  47
atggactcta accagggtaa caaccagcag aactaccagc agtactctca gaacggtaac     60

cagcagcagg gtaacaaccg ttaccagggt taccaggctt acaacgctca ggctcagccg    120

ggtggtggtt actaccagaa ctaccagggt tactccggtt atcagcaagg tggctaccaa    180

caatataatc cagacgctgg ctatcaacag caatataatc ctcagggtgg ttaccagcag    240

tacaacccgc aaggcggtta tcaacaccag ttcaatccgc agggtggtcg tggtaactac    300

aaaaacttca actacaacaa caacctgcag ggttaccagg ctggaattat gaagatcggc    360

attgtgaccg gcattccggg cgttggcaaa agcaccgttc tggcaaaggt gaaggagatc    420

ctggacaacc agggcattaa taacaaaatt attaattatg gtgattttat gctggcgacc    480

gcgctgaagc tgggctacgc aaaagatcgt gacgaaatgc gcaaactgag cgtggaaaaa    540

cagaagaagc tgcagattga tgcggcgaag ggcattgcgg aagaggcacg cgcgggcggc    600

gaaggctacc tgtttatcga tacccatgcg gtgatccgca ccccgagcgg ttatctgccg    660

ggcctgccgt cttacgtgat tacggaaatc aacccgagcg ttatttttct gctggaggca    720

gatccgaaga ttattctgag ccgccagaag cgcgatacca cccgcaaccg caacgattat    780

agcgacgaaa gcgttatcct ggagaccatc aactttgcgc gctatgcggc aaccgcgagc    840

gcggttctgg caggctctac cgttaaagtg atcgtgaacg tggagggtga tccaagcatc    900

gcggcgaacg aaatcattcg cagcatgaaa taagtcgacg c                        941


<210>  48
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of Adenylate kinase from Sulfolobus 
       acidcaldarius fused at the N-terminus with Sup35 N-terminal 
       domain from Saccharomyces cerevisiae

<400>  48

Met Asp Ser Asn Gln Gly Asn Asn Gln Gln Asn Tyr Gln Gln Tyr Ser 
1               5                   10                  15      


Gln Asn Gly Asn Gln Gln Gln Gly Asn Asn Arg Tyr Gln Gly Tyr Gln 
            20                  25                  30          


Ala Tyr Asn Ala Gln Ala Gln Pro Gly Gly Gly Tyr Tyr Gln Asn Tyr 
        35                  40                  45              


Gln Gly Tyr Ser Gly Tyr Gln Gln Gly Gly Tyr Gln Gln Tyr Asn Pro 
    50                  55                  60                  


Asp Ala Gly Tyr Gln Gln Gln Tyr Asn Pro Gln Gly Gly Tyr Gln Gln 
65                  70                  75                  80  


Tyr Asn Pro Gln Gly Gly Tyr Gln His Gln Phe Asn Pro Gln Gly Gly 
                85                  90                  95      


Arg Gly Asn Tyr Lys Asn Phe Asn Tyr Asn Asn Asn Leu Gln Gly Tyr 
            100                 105                 110         


Gln Ala Gly Ile Met Lys Ile Gly Ile Val Thr Gly Ile Pro Gly Val 
        115                 120                 125             


Gly Lys Ser Thr Val Leu Ala Lys Val Lys Glu Ile Leu Asp Asn Gln 
    130                 135                 140                 


Gly Ile Asn Asn Lys Ile Ile Asn Tyr Gly Asp Phe Met Leu Ala Thr 
145                 150                 155                 160 


Ala Leu Lys Leu Gly Tyr Ala Lys Asp Arg Asp Glu Met Arg Lys Leu 
                165                 170                 175     


Ser Val Glu Lys Gln Lys Lys Leu Gln Ile Asp Ala Ala Lys Gly Ile 
            180                 185                 190         


Ala Glu Glu Ala Arg Ala Gly Gly Glu Gly Tyr Leu Phe Ile Asp Thr 
        195                 200                 205             


His Ala Val Ile Arg Thr Pro Ser Gly Tyr Leu Pro Gly Leu Pro Ser 
    210                 215                 220                 


Tyr Val Ile Thr Glu Ile Asn Pro Ser Val Ile Phe Leu Leu Glu Ala 
225                 230                 235                 240 


Asp Pro Lys Ile Ile Leu Ser Arg Gln Lys Arg Asp Thr Thr Arg Asn 
                245                 250                 255     


Arg Asn Asp Tyr Ser Asp Glu Ser Val Ile Leu Glu Thr Ile Asn Phe 
            260                 265                 270         


Ala Arg Tyr Ala Ala Thr Ala Ser Ala Val Leu Ala Gly Ser Thr Val 
        275                 280                 285             


Lys Val Ile Val Asn Val Glu Gly Asp Pro Ser Ile Ala Ala Asn Glu 
    290                 295                 300                 


Ile Ile Arg Ser Met Lys 
305                 310 


<210>  49
<211>  947
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of E. coli codon biased Adenylate kinase from 
       Sulfolobus acidcaldarius fused at the C-terminus with Sup35 
       N-terminal domain from Saccharomyces cerevisiae

<400>  49
atgaagatcg gcattgtgac cggcattccg ggcgttggca aaagcaccgt tctggcaaag     60

gtgaaggaga tcctggacaa ccagggcatt aataacaaaa ttattaatta tggtgatttt    120

atgctggcga ccgcgctgaa gctgggctac gcaaaagatc gtgacgaaat gcgcaaactg    180

agcgtggaaa aacagaagaa gctgcagatt gatgcggcga agggcattgc ggaagaggca    240

cgcgcgggcg gcgaaggcta cctgtttatc gatacccatg cggtgatccg caccccgagc    300

ggttatctgc cgggcctgcc gtcttacgtg attacggaaa tcaacccgag cgttattttt    360

ctgctggagg cagatccgaa gattattctg agccgccaga agcgcgatac cacccgcaac    420

cgcaacgatt atagcgacga aagcgttatc ctggagacca tcaactttgc gcgctatgcg    480

gcaaccgcga gcgcggttct ggcaggctct accgttaaag tgatcgtgaa cgtggagggt    540

gatccaagca tcgcggcgaa cgaaatcatt cgcagcatga aacagtcgag tatggactct    600

aaccagggta acaaccagca gaactaccag cagtactctc agaacggtaa ccagcagcag    660

ggtaacaacc gttaccaggg ttaccaggct tacaacgctc aggctcagcc gggtggtggt    720

tactaccaga actaccaggg ttactccggt tatcagcaag gtggctacca acaatataat    780

ccagacgctg gctatcaaca gcaatataat cctcagggtg gttaccagca gtacaacccg    840

caaggcggtt atcaacacca gttcaatccg cagggtggtc gtggtaacta caaaaacttc    900

aactacaaca acaacctgca gggttaccag gctggttaag tcgacgc                  947


<210>  50
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of Adenylate kinase from Sulfolobus 
       acidcaldarius fused at the C-terminus with Sup35 N-terminal 
       domain from Saccharomyces cerevisiae

<400>  50

Met Lys Ile Gly Ile Val Thr Gly Ile Pro Gly Val Gly Lys Ser Thr 
1               5                   10                  15      


Val Leu Ala Lys Val Lys Glu Ile Leu Asp Asn Gln Gly Ile Asn Asn 
            20                  25                  30          


Lys Ile Ile Asn Tyr Gly Asp Phe Met Leu Ala Thr Ala Leu Lys Leu 
        35                  40                  45              


Gly Tyr Ala Lys Asp Arg Asp Glu Met Arg Lys Leu Ser Val Glu Lys 
    50                  55                  60                  


Gln Lys Lys Leu Gln Ile Asp Ala Ala Lys Gly Ile Ala Glu Glu Ala 
65                  70                  75                  80  


Arg Ala Gly Gly Glu Gly Tyr Leu Phe Ile Asp Thr His Ala Val Ile 
                85                  90                  95      


Arg Thr Pro Ser Gly Tyr Leu Pro Gly Leu Pro Ser Tyr Val Ile Thr 
            100                 105                 110         


Glu Ile Asn Pro Ser Val Ile Phe Leu Leu Glu Ala Asp Pro Lys Ile 
        115                 120                 125             


Ile Leu Ser Arg Gln Lys Arg Asp Thr Thr Arg Asn Arg Asn Asp Tyr 
    130                 135                 140                 


Ser Asp Glu Ser Val Ile Leu Glu Thr Ile Asn Phe Ala Arg Tyr Ala 
145                 150                 155                 160 


Ala Thr Ala Ser Ala Val Leu Ala Gly Ser Thr Val Lys Val Ile Val 
                165                 170                 175     


Asn Val Glu Gly Asp Pro Ser Ile Ala Ala Asn Glu Ile Ile Arg Ser 
            180                 185                 190         


Met Lys Gln Ser Ser Met Asp Ser Asn Gln Gly Asn Asn Gln Gln Asn 
        195                 200                 205             


Tyr Gln Gln Tyr Ser Gln Asn Gly Asn Gln Gln Gln Gly Asn Asn Arg 
    210                 215                 220                 


Tyr Gln Gly Tyr Gln Ala Tyr Asn Ala Gln Ala Gln Pro Gly Gly Gly 
225                 230                 235                 240 


Tyr Tyr Gln Asn Tyr Gln Gly Tyr Ser Gly Tyr Gln Gln Gly Gly Tyr 
                245                 250                 255     


Gln Gln Tyr Asn Pro Asp Ala Gly Tyr Gln Gln Gln Tyr Asn Pro Gln 
            260                 265                 270         


Gly Gly Tyr Gln Gln Tyr Asn Pro Gln Gly Gly Tyr Gln His Gln Phe 
        275                 280                 285             


Asn Pro Gln Gly Gly Arg Gly Asn Tyr Lys Asn Phe Asn Tyr Asn Asn 
    290                 295                 300                 


Asn Leu Gln Gly Tyr Gln Ala Gly 
305                 310         


<210>  51
<211>  1011
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Sup35N fused at the 5' end of adenylate kinase 
       from Thermotoga maritima.

<400>  51
atggactcta accagggtaa caaccagcag aactaccagc agtactctca gaacggtaac     60

cagcagcagg gtaacaaccg ttaccagggt taccaggctt acaacgctca ggctcagccg    120

ggtggtggtt actaccagaa ctaccagggt tactccggtt atcagcaagg tggctaccaa    180

caatataatc cagacgctgg ctatcaacag caatataatc ctcagggtgg ttaccagcag    240

tacaacccgc aaggcggtta tcaacaccag ttcaatccgc agggtggtcg tggtaactac    300

aaaaacttca actacaacaa caacctgcag ggttaccagg ctggaattat gatggcctat    360

ctggtttttc ttggtccacc gggggcaggc aaaggtacct atgcgaaacg tttacaggaa    420

atcaccggca tcccgcacat tagcacgggc gacatttttc gtgatattgt caaaaaggaa    480

aatgacgaat taggtaagaa aattaaagaa attatggagc gcggcgagtt ggtgccggac    540

gaactggtga atgaagttgt caaacgtcgg ctgtctgaaa aggattgcga acgtggcttt    600

attttggacg gttacccgcg tacagtagct caggcagagt ttctcgacgg cttcctgaag    660

actcagaata aggagttaac ggctgcggtc ctgttcgagg tgcctgaaga ggtggtcgtt    720

cagcgtctga ccgcgcggcg tatctgcccg aagtgtggtc gtatttacaa cctgatttca    780

cttcctccaa aagaagatga actgtgtgat gactgcaaag taaaactggt gcaacgcgaa    840

gatgataaag aggaaactgt gcgccatcgc tacaaagtat atctggaaaa aacccaaccg    900

gttatcgatt attatgataa aaaaggcatt ttgaaacgcg ttgatgggac catcggcatc    960

gataacgtga ttgccgaagt tctcaaaatc attgggtgga gtgataaata g            1011


<210>  52
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of adenylate kinase from Thermotoga maritima 
       fused at the N-terminal with Sup35N.

<400>  52

Met Asp Ser Asn Gln Gly Asn Asn Gln Gln Asn Tyr Gln Gln Tyr Ser 
1               5                   10                  15      


Gln Asn Gly Asn Gln Gln Gln Gly Asn Asn Arg Tyr Gln Gly Tyr Gln 
            20                  25                  30          


Ala Tyr Asn Ala Gln Ala Gln Pro Gly Gly Gly Tyr Tyr Gln Asn Tyr 
        35                  40                  45              


Gln Gly Tyr Ser Gly Tyr Gln Gln Gly Gly Tyr Gln Gln Tyr Asn Pro 
    50                  55                  60                  


Asp Ala Gly Tyr Gln Gln Gln Tyr Asn Pro Gln Gly Gly Tyr Gln Gln 
65                  70                  75                  80  


Tyr Asn Pro Gln Gly Gly Tyr Gln His Gln Phe Asn Pro Gln Gly Gly 
                85                  90                  95      


Arg Gly Asn Tyr Lys Asn Phe Asn Tyr Asn Asn Asn Leu Gln Gly Tyr 
            100                 105                 110         


Gln Ala Gly Ile Met Met Ala Tyr Leu Val Phe Leu Gly Pro Pro Gly 
        115                 120                 125             


Ala Gly Lys Gly Thr Tyr Ala Lys Arg Leu Gln Glu Ile Thr Gly Ile 
    130                 135                 140                 


Pro His Ile Ser Thr Gly Asp Ile Phe Arg Asp Ile Val Lys Lys Glu 
145                 150                 155                 160 


Asn Asp Glu Leu Gly Lys Lys Ile Lys Glu Ile Met Glu Arg Gly Glu 
                165                 170                 175     


Leu Val Pro Asp Glu Leu Val Asn Glu Val Val Lys Arg Arg Leu Ser 
            180                 185                 190         


Glu Lys Asp Cys Glu Arg Gly Phe Ile Leu Asp Gly Tyr Pro Arg Thr 
        195                 200                 205             


Val Ala Gln Ala Glu Phe Leu Asp Gly Phe Leu Lys Thr Gln Asn Lys 
    210                 215                 220                 


Glu Leu Thr Ala Ala Val Leu Phe Glu Val Pro Glu Glu Val Val Val 
225                 230                 235                 240 


Gln Arg Leu Thr Ala Arg Arg Ile Cys Pro Lys Cys Gly Arg Ile Tyr 
                245                 250                 255     


Asn Leu Ile Ser Leu Pro Pro Lys Glu Asp Glu Leu Cys Asp Asp Cys 
            260                 265                 270         


Lys Val Lys Leu Val Gln Arg Glu Asp Asp Lys Glu Glu Thr Val Arg 
        275                 280                 285             


His Arg Tyr Lys Val Tyr Leu Glu Lys Thr Gln Pro Val Ile Asp Tyr 
    290                 295                 300                 


Tyr Asp Lys Lys Gly Ile Leu Lys Arg Val Asp Gly Thr Ile Gly Ile 
305                 310                 315                 320 


Asp Asn Val Ile Ala Glu Val Leu Lys Ile Ile Gly Trp Ser Asp Lys 
                325                 330                 335     


<210>  53
<211>  1025
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Sup35N fused at the 3' end of adenylate kinase 
       from Thermotoga maritima.

<400>  53

Ala Thr Gly Ala Thr Gly Gly Cys Cys Thr Ala Thr Cys Thr Gly Gly 
1               5                   10                  15      


Thr Thr Thr Thr Thr Cys Thr Thr Gly Gly Thr Cys Cys Ala Cys Cys 
            20                  25                  30          


Gly Gly Gly Gly Gly Cys Ala Gly Gly Cys Ala Ala Ala Gly Gly Thr 
        35                  40                  45              


Ala Cys Cys Thr Ala Thr Gly Cys Gly Ala Ala Ala Cys Gly Thr Thr 
    50                  55                  60                  


Thr Ala Cys Ala Gly Gly Ala Ala Ala Thr Cys Ala Cys Cys Gly Gly 
65                  70                  75                  80  


Cys Ala Thr Cys Cys Cys Gly Cys Ala Cys Ala Thr Thr Ala Gly Cys 
                85                  90                  95      


Ala Cys Gly Gly Gly Cys Gly Ala Cys Ala Thr Thr Thr Thr Thr Cys 
            100                 105                 110         


Gly Thr Gly Ala Thr Ala Thr Thr Gly Thr Cys Ala Ala Ala Ala Ala 
        115                 120                 125             


Gly Gly Ala Ala Ala Ala Thr Gly Ala Cys Gly Ala Ala Thr Thr Ala 
    130                 135                 140                 


Gly Gly Thr Ala Ala Gly Ala Ala Ala Ala Thr Thr Ala Ala Ala Gly 
145                 150                 155                 160 


Ala Ala Ala Thr Thr Ala Thr Gly Gly Ala Gly Cys Gly Cys Gly Gly 
                165                 170                 175     


Cys Gly Ala Gly Thr Thr Gly Gly Thr Gly Cys Cys Gly Gly Ala Cys 
            180                 185                 190         


Gly Ala Ala Cys Thr Gly Gly Thr Gly Ala Ala Thr Gly Ala Ala Gly 
        195                 200                 205             


Thr Thr Gly Thr Cys Ala Ala Ala Cys Gly Thr Cys Gly Gly Cys Thr 
    210                 215                 220                 


Gly Thr Cys Thr Gly Ala Ala Ala Ala Gly Gly Ala Thr Thr Gly Cys 
225                 230                 235                 240 


Gly Ala Ala Cys Gly Thr Gly Gly Cys Thr Thr Thr Ala Thr Thr Thr 
                245                 250                 255     


Thr Gly Gly Ala Cys Gly Gly Thr Thr Ala Cys Cys Cys Gly Cys Gly 
            260                 265                 270         


Thr Ala Cys Ala Gly Thr Ala Gly Cys Thr Cys Ala Gly Gly Cys Ala 
        275                 280                 285             


Gly Ala Gly Thr Thr Thr Cys Thr Cys Gly Ala Cys Gly Gly Cys Thr 
    290                 295                 300                 


Thr Cys Cys Thr Gly Ala Ala Gly Ala Cys Thr Cys Ala Gly Ala Ala 
305                 310                 315                 320 


Thr Ala Ala Gly Gly Ala Gly Thr Thr Ala Ala Cys Gly Gly Cys Thr 
                325                 330                 335     


Gly Cys Gly Gly Thr Cys Cys Thr Gly Thr Thr Cys Gly Ala Gly Gly 
            340                 345                 350         


Thr Gly Cys Cys Thr Gly Ala Ala Gly Ala Gly Gly Thr Gly Gly Thr 
        355                 360                 365             


Cys Gly Thr Thr Cys Ala Gly Cys Gly Thr Cys Thr Gly Ala Cys Cys 
    370                 375                 380                 


Gly Cys Gly Cys Gly Gly Cys Gly Thr Ala Thr Cys Thr Gly Cys Cys 
385                 390                 395                 400 


Cys Gly Ala Ala Gly Thr Gly Thr Gly Gly Thr Cys Gly Thr Ala Thr 
                405                 410                 415     


Thr Thr Ala Cys Ala Ala Cys Cys Thr Gly Ala Thr Thr Thr Cys Ala 
            420                 425                 430         


Cys Thr Thr Cys Cys Thr Cys Cys Ala Ala Ala Ala Gly Ala Ala Gly 
        435                 440                 445             


Ala Thr Gly Ala Ala Cys Thr Gly Thr Gly Thr Gly Ala Thr Gly Ala 
    450                 455                 460                 


Cys Thr Gly Cys Ala Ala Ala Gly Thr Ala Ala Ala Ala Cys Thr Gly 
465                 470                 475                 480 


Gly Thr Gly Cys Ala Ala Cys Gly Cys Gly Ala Ala Gly Ala Thr Gly 
                485                 490                 495     


Ala Thr Ala Ala Ala Gly Ala Gly Gly Ala Ala Ala Cys Thr Gly Thr 
            500                 505                 510         


Gly Cys Gly Cys Cys Ala Thr Cys Gly Cys Thr Ala Cys Ala Ala Ala 
        515                 520                 525             


Gly Thr Ala Thr Ala Thr Cys Thr Gly Gly Ala Ala Ala Ala Ala Ala 
    530                 535                 540                 


Cys Cys Cys Ala Ala Cys Cys Gly Gly Thr Thr Ala Thr Cys Gly Ala 
545                 550                 555                 560 


Thr Thr Ala Thr Thr Ala Thr Gly Ala Thr Ala Ala Ala Ala Ala Ala 
                565                 570                 575     


Gly Gly Cys Ala Thr Thr Thr Thr Gly Ala Ala Ala Cys Gly Cys Gly 
            580                 585                 590         


Thr Thr Gly Ala Thr Gly Gly Gly Ala Cys Cys Ala Thr Cys Gly Gly 
        595                 600                 605             


Cys Ala Thr Cys Gly Ala Thr Ala Ala Cys Gly Thr Gly Ala Thr Thr 
    610                 615                 620                 


Gly Cys Cys Gly Ala Ala Gly Thr Thr Cys Thr Cys Ala Ala Ala Ala 
625                 630                 635                 640 


Thr Cys Ala Thr Thr Gly Gly Gly Thr Gly Gly Ala Gly Thr Gly Ala 
                645                 650                 655     


Thr Ala Ala Ala Cys Thr Gly Thr Cys Gly Ala Gly Thr Ala Thr Gly 
            660                 665                 670         


Gly Ala Cys Thr Cys Thr Ala Ala Cys Cys Ala Gly Gly Gly Thr Ala 
        675                 680                 685             


Ala Cys Ala Ala Cys Cys Ala Gly Cys Ala Gly Ala Ala Cys Thr Ala 
    690                 695                 700                 


Cys Cys Ala Gly Cys Ala Gly Thr Ala Cys Thr Cys Thr Cys Ala Gly 
705                 710                 715                 720 


Ala Ala Cys Gly Gly Thr Ala Ala Cys Cys Ala Gly Cys Ala Gly Cys 
                725                 730                 735     


Ala Gly Gly Gly Thr Ala Ala Cys Ala Ala Cys Cys Gly Thr Thr Ala 
            740                 745                 750         


Cys Cys Ala Gly Gly Gly Thr Thr Ala Cys Cys Ala Gly Gly Cys Thr 
        755                 760                 765             


Thr Ala Cys Ala Ala Cys Gly Cys Thr Cys Ala Gly Gly Cys Thr Cys 
    770                 775                 780                 


Ala Gly Cys Cys Gly Gly Gly Thr Gly Gly Thr Gly Gly Thr Thr Ala 
785                 790                 795                 800 


Cys Thr Ala Cys Cys Ala Gly Ala Ala Cys Thr Ala Cys Cys Ala Gly 
                805                 810                 815     


Gly Gly Thr Thr Ala Cys Thr Cys Cys Gly Gly Thr Thr Ala Thr Cys 
            820                 825                 830         


Ala Gly Cys Ala Ala Gly Gly Thr Gly Gly Cys Thr Ala Cys Cys Ala 
        835                 840                 845             


Ala Cys Ala Ala Thr Ala Thr Ala Ala Thr Cys Cys Ala Gly Ala Cys 
    850                 855                 860                 


Gly Cys Thr Gly Gly Cys Thr Ala Thr Cys Ala Ala Cys Ala Gly Cys 
865                 870                 875                 880 


Ala Ala Thr Ala Thr Ala Ala Thr Cys Cys Thr Cys Ala Gly Gly Gly 
                885                 890                 895     


Thr Gly Gly Thr Thr Ala Cys Cys Ala Gly Cys Ala Gly Thr Ala Cys 
            900                 905                 910         


Ala Ala Cys Cys Cys Gly Cys Ala Ala Gly Gly Cys Gly Gly Thr Thr 
        915                 920                 925             


Ala Thr Cys Ala Ala Cys Ala Cys Cys Ala Gly Thr Thr Cys Ala Ala 
    930                 935                 940                 


Thr Cys Cys Gly Cys Ala Gly Gly Gly Thr Gly Gly Thr Cys Gly Thr 
945                 950                 955                 960 


Gly Gly Thr Ala Ala Cys Thr Ala Cys Ala Ala Ala Ala Ala Cys Thr 
                965                 970                 975     


Thr Cys Ala Ala Cys Thr Ala Cys Ala Ala Cys Ala Ala Cys Ala Ala 
            980                 985                 990         


Cys Cys Thr Gly Cys Ala Gly Gly  Gly Thr Thr Ala Cys  Cys Ala Gly 
        995                 1000                 1005             


Gly Cys  Thr Gly Gly Thr Thr  Ala Ala Gly Thr Cys  Gly Ala Cys 
    1010                 1015                 1020             


Gly Cys  
    1025 


<210>  54
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of adenylate kinase from Thermotoga maritima 
       fused at the C-terminal fusion with Sup35N

<400>  54

Met Met Ala Tyr Leu Val Phe Leu Gly Pro Pro Gly Ala Gly Lys Gly 
1               5                   10                  15      


Thr Tyr Ala Lys Arg Leu Gln Glu Ile Thr Gly Ile Pro His Ile Ser 
            20                  25                  30          


Thr Gly Asp Ile Phe Arg Asp Ile Val Lys Lys Glu Asn Asp Glu Leu 
        35                  40                  45              


Gly Lys Lys Ile Lys Glu Ile Met Glu Arg Gly Glu Leu Val Pro Asp 
    50                  55                  60                  


Glu Leu Val Asn Glu Val Val Lys Arg Arg Leu Ser Glu Lys Asp Cys 
65                  70                  75                  80  


Glu Arg Gly Phe Ile Leu Asp Gly Tyr Pro Arg Thr Val Ala Gln Ala 
                85                  90                  95      


Glu Phe Leu Asp Gly Phe Leu Lys Thr Gln Asn Lys Glu Leu Thr Ala 
            100                 105                 110         


Ala Val Leu Phe Glu Val Pro Glu Glu Val Val Val Gln Arg Leu Thr 
        115                 120                 125             


Ala Arg Arg Ile Cys Pro Lys Cys Gly Arg Ile Tyr Asn Leu Ile Ser 
    130                 135                 140                 


Leu Pro Pro Lys Glu Asp Glu Leu Cys Asp Asp Cys Lys Val Lys Leu 
145                 150                 155                 160 


Val Gln Arg Glu Asp Asp Lys Glu Glu Thr Val Arg His Arg Tyr Lys 
                165                 170                 175     


Val Tyr Leu Glu Lys Thr Gln Pro Val Ile Asp Tyr Tyr Asp Lys Lys 
            180                 185                 190         


Gly Ile Leu Lys Arg Val Asp Gly Thr Ile Gly Ile Asp Asn Val Ile 
        195                 200                 205             


Ala Glu Val Leu Lys Ile Ile Gly Trp Ser Asp Lys Leu Ser Ser Met 
    210                 215                 220                 


Asp Ser Asn Gln Gly Asn Asn Gln Gln Asn Tyr Gln Gln Tyr Ser Gln 
225                 230                 235                 240 


Asn Gly Asn Gln Gln Gln Gly Asn Asn Arg Tyr Gln Gly Tyr Gln Ala 
                245                 250                 255     


Tyr Asn Ala Gln Ala Gln Pro Gly Gly Gly Tyr Tyr Gln Asn Tyr Gln 
            260                 265                 270         


Gly Tyr Ser Gly Tyr Gln Gln Gly Gly Tyr Gln Gln Tyr Asn Pro Asp 
        275                 280                 285             


Ala Gly Tyr Gln Gln Gln Tyr Asn Pro Gln Gly Gly Tyr Gln Gln Tyr 
    290                 295                 300                 


Asn Pro Gln Gly Gly Tyr Gln His Gln Phe Asn Pro Gln Gly Gly Arg 
305                 310                 315                 320 


Gly Asn Tyr Lys Asn Phe Asn Tyr Asn Asn Asn Leu Gln Gly Tyr Gln 
                325                 330                 335     


Ala Gly 
        


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding a short Sup35 peptide capable of 
       aggregating to form amyloid fibrils; for use as a fusion peptide 
       with tAK genes.

<400>  55
ggtaacaacc agcagaacta c                                               21


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sup35 derived amyloid peptide

<400>  56

Gly Asn Asn Gln Gln Asn Tyr 
1               5           


<210>  57
<211>  1593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding a Norovirus capsid protein (58kDa)

<400>  57
atgatgatgg cgtctaagga cgctacatca agcgtggatg gcgctagtgg cgctggtcag     60

ttggtaccgg aggttaatgc ttctgaccct cttgcaatgg atcctgtagc aggttcttcg    120

acagcagtcg cgactgctgg acaagttaat cctattgatc cctggataat taataatttt    180

gtgcaagccc cccaaggtga atttactatt tccccaaata atacccccgg tgatgttttg    240

tttgatttga gtttgggtcc ccatcttaat cctttcttgc tccatctatc acaaatgtat    300

aatggttggg ttggtaacat gagagtcagg attatgctag ctggtaatgc ctttactgcg    360

gggaagataa tagtttcctg cataccccct ggttttggtt cacataatct tactatagca    420

caagcaactc tctttccaca tgtgattgct gatgttagga ctctagaccc cattgaggtg    480

cctttggaag atgttaggaa tgttctcttt cataataatg atagaaatca acaaaccatg    540

cgccttgtgt gcatgctgta cacccccctc cgcactggtg gtggtactgg tgattctttt    600

gtagttgcag ggcgagttat gacttgcccc agtcctgatt ttaatttctt gtttttagtc    660

cctcctacgg tggagcagaa aaccaggccc ttcacactcc caaatctgcc attgagttct    720

ctgtctaact cacgtgcccc tctcccaatc agtagtatgg gcatttcccc agacaatgtc    780

cagagtgtgc agttccaaaa tggtcggtgt actctggatg gccgcctggt tggcaccacc    840

ccagtttcat tgtcacatgt tgccaagata agagggacct ccaatggcac tgtaatcaac    900

cttactgaat tggatggcac accctttcac ccttttgagg gccctgcccc cattgggttt    960

ccagacctcg gtggttgtga ttggcatatc aatatgacac agtttggcca ttctagccag   1020

acccagtatg atgtagacac cacccctgac acttttgtcc cccatcttgg ttcaattcag   1080

gcaaatggca ttggcagtgg taattatgtt ggtgttctta gctggatttc ccccccatca   1140

cacccgtctg gctcccaagt tgacctttgg aagatcccca attatgggtc aagtattacg   1200

gaggcaacac atctagcccc ttctgtatac ccccctggtt tcggagaggt attggtcttt   1260

ttcatgtcaa aaatgccagg tcctggtgct tataatttgc cctgtctatt accacaagag   1320

tacatttcac atcttgctag tgaacaagcc cctactgtag gtgaggctgc cctgctccac   1380

tatgttgacc ctgataccgg tcggaatctt ggggaattca aagcataccc tgatggtttc   1440

ctcacttgtg tccccaatgg ggctagctcg ggtccacaac agctgccgat caatggggtc   1500

tttgtctttg tttcatgggt gtccagattt tatcaattaa agcctgtggg aactgccagc   1560

tcggcaagag gtaggcttgg tctgcgccga taa                                1593


<210>  58
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of Norovirus capsid protein (58kDa)

<400>  58

Met Met Met Ala Ser Lys Asp Ala Thr Ser Ser Val Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ser Asp Pro Leu Ala 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ser Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Pro Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Ser Leu Gly Pro His Leu Asn Pro Phe Leu Leu His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Val Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Gly Ser His Asn Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Arg Asn 
                165                 170                 175     


Gln Gln Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Thr Gly Asp Ser Phe Val Val Ala Gly Arg Val Met Thr 
        195                 200                 205             


Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val 
    210                 215                 220                 


Glu Gln Lys Thr Arg Pro Phe Thr Leu Pro Asn Leu Pro Leu Ser Ser 
225                 230                 235                 240 


Leu Ser Asn Ser Arg Ala Pro Leu Pro Ile Ser Ser Met Gly Ile Ser 
                245                 250                 255     


Pro Asp Asn Val Gln Ser Val Gln Phe Gln Asn Gly Arg Cys Thr Leu 
            260                 265                 270         


Asp Gly Arg Leu Val Gly Thr Thr Pro Val Ser Leu Ser His Val Ala 
        275                 280                 285             


Lys Ile Arg Gly Thr Ser Asn Gly Thr Val Ile Asn Leu Thr Glu Leu 
    290                 295                 300                 


Asp Gly Thr Pro Phe His Pro Phe Glu Gly Pro Ala Pro Ile Gly Phe 
305                 310                 315                 320 


Pro Asp Leu Gly Gly Cys Asp Trp His Ile Asn Met Thr Gln Phe Gly 
                325                 330                 335     


His Ser Ser Gln Thr Gln Tyr Asp Val Asp Thr Thr Pro Asp Thr Phe 
            340                 345                 350         


Val Pro His Leu Gly Ser Ile Gln Ala Asn Gly Ile Gly Ser Gly Asn 
        355                 360                 365             


Tyr Val Gly Val Leu Ser Trp Ile Ser Pro Pro Ser His Pro Ser Gly 
    370                 375                 380                 


Ser Gln Val Asp Leu Trp Lys Ile Pro Asn Tyr Gly Ser Ser Ile Thr 
385                 390                 395                 400 


Glu Ala Thr His Leu Ala Pro Ser Val Tyr Pro Pro Gly Phe Gly Glu 
                405                 410                 415     


Val Leu Val Phe Phe Met Ser Lys Met Pro Gly Pro Gly Ala Tyr Asn 
            420                 425                 430         


Leu Pro Cys Leu Leu Pro Gln Glu Tyr Ile Ser His Leu Ala Ser Glu 
        435                 440                 445             


Gln Ala Pro Thr Val Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro 
    450                 455                 460                 


Asp Thr Gly Arg Asn Leu Gly Glu Phe Lys Ala Tyr Pro Asp Gly Phe 
465                 470                 475                 480 


Leu Thr Cys Val Pro Asn Gly Ala Ser Ser Gly Pro Gln Gln Leu Pro 
                485                 490                 495     


Ile Asn Gly Val Phe Val Phe Val Ser Trp Val Ser Arg Phe Tyr Gln 
            500                 505                 510         


Leu Lys Pro Val Gly Thr Ala Ser Ser Ala Arg Gly Arg Leu Gly Leu 
        515                 520                 525             


Arg Arg 
    530 


<210>  59
<211>  1593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence for a synthetic gene encoding a Norovirus capsid 
       protein (58kDa) optimised for expression in E.coli

<400>  59
atgatgatgg cttctaaaga cgctacctct tctgttgacg gtgcttctgg tgctggtcag     60

ctggttccgg aagttaacgc ttctgacccg ctggctatgg acccggttgc tggttcttct    120

accgctgttg ctaccgctgg tcaggttaac ccgatcgacc cgtggatcat caacaacttc    180

gttcaggctc cgcagggtga attcaccatc tctccgaaca acaccccggg tgacgttctg    240

ttcgacctgt ctctgggtcc gcacctgaac ccgttcctgc tgcacctgtc tcagatgtac    300

aacggttggg ttggtaacat gcgtgttcgt atcatgctgg ctggtaacgc tttcaccgct    360

ggtaaaatca tcgtttcttg catcccgccg ggtttcggtt ctcacaacct gaccatcgct    420

caggctaccc tgttcccgca cgttatcgct gacgttcgta ccctggaccc gatcgaagtt    480

ccgctggaag acgttcgtaa cgttctgttc cacaacaacg accgtaacca gcagaccatg    540

cgtctggttt gcatgctgta caccccgctg cgtaccggtg gtggtaccgg tgactctttc    600

gttgttgctg gtcgtgttat gacctgcccg tctccggact tcaacttcct gttcctggtt    660

ccgccgaccg ttgaacagaa aacccgtccg ttcaccctgc cgaacctgcc gctgtcttct    720

ctgtctaact ctcgtgctcc gctgccgatc tcttctatgg gtatctctcc ggacaacgtt    780

cagtctgttc agttccagaa cggtcgttgc accctggacg gtcgtctggt tggtaccacc    840

ccggtttctc tgtctcacgt tgctaaaatc cgtggtacct ctaacggtac cgttatcaac    900

ctgaccgaac tggacggtac cccgttccac ccgttcgaag gtccggctcc gatcggtttc    960

ccggacctgg gtggttgcga ctggcacatc aacatgaccc agttcggtca ctcttctcag   1020

acccagtacg acgttgacac caccccggac accttcgttc cgcacctggg ttctatccag   1080

gctaacggta tcggttctgg taactacgtt ggtgttctgt cttggatctc tccgccgtct   1140

cacccgtctg gttctcaggt tgacctgtgg aaaatcccga actacggttc ttctatcacc   1200

gaagctaccc acctggctcc gtctgtttac ccgccgggtt tcggtgaagt tctggttttc   1260

ttcatgtcta aaatgccggg tccgggtgct tacaacctgc cgtgcctgct gccgcaggaa   1320

tacatctctc acctggcttc tgaacaggct ccgaccgttg gtgaagctgc tctgctgcac   1380

tacgttgacc cggacaccgg tcgtaacctg ggtgaattca aagcttaccc ggacggtttc   1440

ctgacctgcg ttccgaacgg tgcttcttct ggtccgcagc agctgccgat caacggtgtt   1500

ttcgttttcg tttcttgggt ttctcgtttc taccagctga aaccggttgg taccgcttct   1560

tctgctcgtg gtcgtctggg tctgcgtcgt tag                                1593


<210>  60
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence for a synthetic gene encoding a Norovirus capsid 
       protein (58kDa) optimised for expression in E.coli fused at the 
       5' end of a gene encoding the tAK from Thermotoga maritima.

<400>  60
atgatgatgg cttctaaaga cgctacctct tctgttgacg gtgcttctgg tgctggtcag     60

ctggttccgg aagttaacgc ttctgacccg ctggctatgg acccggttgc tggttcttct    120

accgctgttg ctaccgctgg tcaggttaac ccgatcgacc cgtggatcat caacaacttc    180

gttcaggctc cgcagggtga attcaccatc tctccgaaca acaccccggg tgacgttctg    240

ttcgacctgt ctctgggtcc gcacctgaac ccgttcctgc tgcacctgtc tcagatgtac    300

aacggttggg ttggtaacat gcgtgttcgt atcatgctgg ctggtaacgc tttcaccgct    360

ggtaaaatca tcgtttcttg catcccgccg ggtttcggtt ctcacaacct gaccatcgct    420

caggctaccc tgttcccgca cgttatcgct gacgttcgta ccctggaccc gatcgaagtt    480

ccgctggaag acgttcgtaa cgttctgttc cacaacaacg accgtaacca gcagaccatg    540

cgtctggttt gcatgctgta caccccgctg cgtaccggtg gtggtaccgg tgactctttc    600

gttgttgctg gtcgtgttat gacctgcccg tctccggact tcaacttcct gttcctggtt    660

ccgccgaccg ttgaacagaa aacccgtccg ttcaccctgc cgaacctgcc gctgtcttct    720

ctgtctaact ctcgtgctcc gctgccgatc tcttctatgg gtatctctcc ggacaacgtt    780

cagtctgttc agttccagaa cggtcgttgc accctggacg gtcgtctggt tggtaccacc    840

ccggtttctc tgtctcacgt tgctaaaatc cgtggtacct ctaacggtac cgttatcaac    900

ctgaccgaac tggacggtac cccgttccac ccgttcgaag gtccggctcc gatcggtttc    960

ccggacctgg gtggttgcga ctggcacatc aacatgaccc agttcggtca ctcttctcag   1020

acccagtacg acgttgacac caccccggac accttcgttc cgcacctggg ttctatccag   1080

gctaacggta tcggttctgg taactacgtt ggtgttctgt cttggatctc tccgccgtct   1140

cacccgtctg gttctcaggt tgacctgtgg aaaatcccga actacggttc ttctatcacc   1200

gaagctaccc acctggctcc gtctgtttac ccgccgggtt tcggtgaagt tctggttttc   1260

ttcatgtcta aaatgccggg tccgggtgct tacaacctgc cgtgcctgct gccgcaggaa   1320

tacatctctc acctggcttc tgaacaggct ccgaccgttg gtgaagctgc tctgctgcac   1380

tacgttgacc cggacaccgg tcgtaacctg ggtgaattca aagcttaccc ggacggtttc   1440

ctgacctgcg ttccgaacgg tgcttcttct ggtccgcagc agctgccgat caacggtgtt   1500

ttcgttttcg tttcttgggt ttctcgtttc taccagctga aaccggttgg taccgcttct   1560

tctgctcgtg gtcgtctggg tctgcgtcgt atgatggcct atctggtttt tcttggtcca   1620

ccgggggcag gcaaaggtac ctatgcgaaa cgtttacagg aaatcaccgg catcccgcac   1680

attagcacgg gcgacatttt tcgtgatatt gtcaaaaagg aaaatgacga attaggtaag   1740

aaaattaaag aaattatgga gcgcggcgag ttggtgccgg acgaactggt gaatgaagtt   1800

gtcaaacgtc ggctgtctga aaaggattgc gaacgtggct ttattttgga cggttacccg   1860

cgtacagtag ctcaggcaga gtttctcgac ggcttcctga agactcagaa taaggagtta   1920

acggctgcgg tcctgttcga ggtgcctgaa gaggtggtcg ttcagcgtct gaccgcgcgg   1980

cgtatctgcc cgaagtgtgg tcgtatttac aacctgattt cacttcctcc aaaagaagat   2040

gaactgtgtg atgactgcaa agtaaaactg gtgcaacgcg aagatgataa agaggaaact   2100

gtgcgccatc gctacaaagt atatctggaa aaaacccaac cggttatcga ttattatgat   2160

aaaaaaggca ttttgaaacg cgttgatggg accatcggca tcgataacgt gattgccgaa   2220

gttctcaaaa tcattgggtg gagtgataaa                                    2250


<210>  61
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of a Norovirus capsid protein (58kDa) fused at 
       the N-terminus of the adenylate kinase from Thermotoga maritima

<400>  61

Met Met Met Ala Ser Lys Asp Ala Thr Ser Ser Val Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ser Asp Pro Leu Ala 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ser Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Pro Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Ser Leu Gly Pro His Leu Asn Pro Phe Leu Leu His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Val Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Gly Ser His Asn Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Arg Asn 
                165                 170                 175     


Gln Gln Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Thr Gly Asp Ser Phe Val Val Ala Gly Arg Val Met Thr 
        195                 200                 205             


Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val 
    210                 215                 220                 


Glu Gln Lys Thr Arg Pro Phe Thr Leu Pro Asn Leu Pro Leu Ser Ser 
225                 230                 235                 240 


Leu Ser Asn Ser Arg Ala Pro Leu Pro Ile Ser Ser Met Gly Ile Ser 
                245                 250                 255     


Pro Asp Asn Val Gln Ser Val Gln Phe Gln Asn Gly Arg Cys Thr Leu 
            260                 265                 270         


Asp Gly Arg Leu Val Gly Thr Thr Pro Val Ser Leu Ser His Val Ala 
        275                 280                 285             


Lys Ile Arg Gly Thr Ser Asn Gly Thr Val Ile Asn Leu Thr Glu Leu 
    290                 295                 300                 


Asp Gly Thr Pro Phe His Pro Phe Glu Gly Pro Ala Pro Ile Gly Phe 
305                 310                 315                 320 


Pro Asp Leu Gly Gly Cys Asp Trp His Ile Asn Met Thr Gln Phe Gly 
                325                 330                 335     


His Ser Ser Gln Thr Gln Tyr Asp Val Asp Thr Thr Pro Asp Thr Phe 
            340                 345                 350         


Val Pro His Leu Gly Ser Ile Gln Ala Asn Gly Ile Gly Ser Gly Asn 
        355                 360                 365             


Tyr Val Gly Val Leu Ser Trp Ile Ser Pro Pro Ser His Pro Ser Gly 
    370                 375                 380                 


Ser Gln Val Asp Leu Trp Lys Ile Pro Asn Tyr Gly Ser Ser Ile Thr 
385                 390                 395                 400 


Glu Ala Thr His Leu Ala Pro Ser Val Tyr Pro Pro Gly Phe Gly Glu 
                405                 410                 415     


Val Leu Val Phe Phe Met Ser Lys Met Pro Gly Pro Gly Ala Tyr Asn 
            420                 425                 430         


Leu Pro Cys Leu Leu Pro Gln Glu Tyr Ile Ser His Leu Ala Ser Glu 
        435                 440                 445             


Gln Ala Pro Thr Val Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro 
    450                 455                 460                 


Asp Thr Gly Arg Asn Leu Gly Glu Phe Lys Ala Tyr Pro Asp Gly Phe 
465                 470                 475                 480 


Leu Thr Cys Val Pro Asn Gly Ala Ser Ser Gly Pro Gln Gln Leu Pro 
                485                 490                 495     


Ile Asn Gly Val Phe Val Phe Val Ser Trp Val Ser Arg Phe Tyr Gln 
            500                 505                 510         


Leu Lys Pro Val Gly Thr Ala Ser Ser Ala Arg Gly Arg Leu Gly Leu 
        515                 520                 525             


Arg Arg Met Met Ala Tyr Leu Val Phe Leu Gly Pro Pro Gly Ala Gly 
    530                 535                 540                 


Lys Gly Thr Tyr Ala Lys Arg Leu Gln Glu Ile Thr Gly Ile Pro His 
545                 550                 555                 560 


Ile Ser Thr Gly Asp Ile Phe Arg Asp Ile Val Lys Lys Glu Asn Asp 
                565                 570                 575     


Glu Leu Gly Lys Lys Ile Lys Glu Ile Met Glu Arg Gly Glu Leu Val 
            580                 585                 590         


Pro Asp Glu Leu Val Asn Glu Val Val Lys Arg Arg Leu Ser Glu Lys 
        595                 600                 605             


Asp Cys Glu Arg Gly Phe Ile Leu Asp Gly Tyr Pro Arg Thr Val Ala 
    610                 615                 620                 


Gln Ala Glu Phe Leu Asp Gly Phe Leu Lys Thr Gln Asn Lys Glu Leu 
625                 630                 635                 640 


Thr Ala Ala Val Leu Phe Glu Val Pro Glu Glu Val Val Val Gln Arg 
                645                 650                 655     


Leu Thr Ala Arg Arg Ile Cys Pro Lys Cys Gly Arg Ile Tyr Asn Leu 
            660                 665                 670         


Ile Ser Leu Pro Pro Lys Glu Asp Glu Leu Cys Asp Asp Cys Lys Val 
        675                 680                 685             


Lys Leu Val Gln Arg Glu Asp Asp Lys Glu Glu Thr Val Arg His Arg 
    690                 695                 700                 


Tyr Lys Val Tyr Leu Glu Lys Thr Gln Pro Val Ile Asp Tyr Tyr Asp 
705                 710                 715                 720 


Lys Lys Gly Ile Leu Lys Arg Val Asp Gly Thr Ile Gly Ile Asp Asn 
                725                 730                 735     


Val Ile Ala Glu Val Leu Lys Ile Ile Gly Trp Ser Asp Lys 
            740                 745                 750 


<210>  62
<211>  130
<212>  PRT
<213>  Bacteriophage MS2

<400>  62

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr 
    130 


<210>  63
<211>  127
<212>  PRT
<213>  Bacteriophage PP7

<400>  63

Ser Lys Thr Ile Val Leu Ser Val Gly Glu Ala Thr Arg Thr Leu Thr 
1               5                   10                  15      


Glu Ile Gln Ser Thr Ala Asp Arg Gln Ile Phe Glu Glu Lys Val Gly 
            20                  25                  30          


Pro Leu Val Gly Arg Leu Arg Leu Thr Ala Ser Leu Arg Gln Asn Gly 
        35                  40                  45              


Ala Lys Thr Ala Tyr Arg Val Asn Leu Lys Leu Asp Gln Ala Asp Val 
    50                  55                  60                  


Val Asp Cys Ser Thr Ser Val Cys Gly Glu Leu Pro Lys Val Arg Tyr 
65                  70                  75                  80  


Thr Gln Val Trp Ser His Asp Val Thr Ile Val Ala Asn Ser Thr Glu 
                85                  90                  95      


Ala Ser Arg Lys Ser Leu Tyr Asp Leu Thr Lys Ser Leu Val Val Gln 
            100                 105                 110         


Ala Thr Ser Glu Asp Leu Val Val Asn Leu Val Pro Leu Gly Arg 
        115                 120                 125         


<210>  64
<211>  245
<212>  PRT
<213>  Bacteriophage PP7

<400>  64

Met Ser Lys Thr Ile Val Leu Ser Val Gly Glu Ala Thr Arg Thr Leu 
1               5                   10                  15      


Thr Glu Ile Gln Ser Thr Ala Asp Arg Gln Ile Phe Glu Glu Lys Val 
            20                  25                  30          


Gly Pro Leu Val Gly Arg Leu Arg Leu Thr Ala Ser Leu Arg Gln Asn 
        35                  40                  45              


Gly Ala Lys Thr Ala Tyr Arg Val Asn Leu Lys Leu Asp Gln Ala Asp 
    50                  55                  60                  


Val Val Asp Ser Gly Leu Pro Lys Val Arg Tyr Thr Gln Val Trp Ser 
65                  70                  75                  80  


His Asp Val Thr Ile Val Ala Asn Ser Thr Glu Ala Ser Arg Lys Ser 
                85                  90                  95      


Leu Tyr Asp Leu Thr Lys Ser Leu Val Ala Thr Ser Gln Val Glu Asp 
            100                 105                 110         


Leu Val Val Asn Leu Val Pro Leu Gly Arg Tyr Gly Ser Lys Thr Ile 
        115                 120                 125             


Val Leu Ser Val Gly Glu Ala Thr Arg Thr Leu Thr Glu Ile Gln Ser 
    130                 135                 140                 


Thr Ala Asp Arg Gln Ile Phe Glu Glu Lys Val Gly Pro Leu Val Gly 
145                 150                 155                 160 


Arg Leu Arg Leu Thr Ala Ser Leu Arg Gln Asn Gly Ala Lys Thr Ala 
                165                 170                 175     


Tyr Arg Val Asn Leu Lys Leu Asp Gln Ala Asp Val Val Asp Ser Gly 
            180                 185                 190         


Leu Pro Lys Val Arg Tyr Thr Gln Val Trp Ser His Asp Val Thr Ile 
        195                 200                 205             


Val Ala Asn Ser Thr Glu Ala Ser Arg Lys Ser Leu Tyr Asp Leu Thr 
    210                 215                 220                 


Lys Ser Leu Val Ala Thr Ser Gln Val Glu Asp Leu Val Val Asn Leu 
225                 230                 235                 240 


Val Pro Leu Gly Arg 
                245 


<210>  65
<211>  151
<212>  PRT
<213>  Escherichia coli

<400>  65

Met Lys Leu Leu Lys Val Ala Ala Ile Ala Ala Ile Val Phe Ser Gly 
1               5                   10                  15      


Ser Ala Leu Ala Gly Val Val Pro Gln Tyr Gly Gly Gly Gly Asn His 
            20                  25                  30          


Gly Gly Gly Gly Asn Asn Ser Gly Pro Asn Ser Glu Leu Asn Ile Tyr 
        35                  40                  45              


Gln Tyr Gly Gly Gly Asn Ser Ala Leu Ala Leu Gln Thr Asp Ala Arg 
    50                  55                  60                  


Asn Ser Asp Leu Thr Ile Thr Gln His Gly Gly Gly Asn Gly Ala Asp 
65                  70                  75                  80  


Val Gly Gln Gly Ser Asp Asp Ser Ser Ile Asp Leu Thr Gln Arg Gly 
                85                  90                  95      


Phe Gly Asn Ser Ala Thr Leu Asp Gln Trp Asn Gly Lys Asn Ser Glu 
            100                 105                 110         


Met Thr Val Lys Gln Phe Gly Gly Gly Asn Gly Ala Ala Val Asp Gln 
        115                 120                 125             


Thr Ala Ser Asn Ser Ser Val Asn Val Thr Gln Val Gly Phe Gly Asn 
    130                 135                 140                 


Asn Ala Thr Ala His Gln Tyr 
145                 150     


<210>  66
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of AgfA protein from Salmonella

<400>  66

Met Lys Leu Leu Lys Val Ala Ala Phe Ala Ala Ile Val Val Ser Gly 
1               5                   10                  15      


Ser Ala Leu Ala Gly Val Val Pro Gln Trp Gly Gly Gly Gly Asn His 
            20                  25                  30          


Asn Gly Gly Gly Asn Ser Ser Gly Pro Asp Ser Thr Leu Ser Ile Tyr 
        35                  40                  45              


Gln Tyr Gly Ser Ala Asn Ala Ala Leu Ala Leu Gln Ser Asp Ala Arg 
    50                  55                  60                  


Lys Ser Glu Thr Thr Ile Thr Gln Ser Gly Tyr Gly Asn Gly Ala Asp 
65                  70                  75                  80  


Val Gly Gln Gly Ala Asp Asn Ser Thr Ile Glu Leu Thr Gln Asn Gly 
                85                  90                  95      


Phe Arg Asn Asn Ala Thr Ile Asp Gln Trp Asn Ala Lys Asn Ser Asp 
            100                 105                 110         


Ile Thr Val Gly Gln Tyr Gly Gly Asn Asn Ala Ala Leu Val Asn Gln 
        115                 120                 125             


Thr Ala Ser Asp Ser Ser Val Met Val Arg Gln Val Gly Phe Gly Asn 
    130                 135                 140                 


Asn Ala Thr Ala Asn Gln Tyr 
145                 150     


<210>  67
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of adenylate kinase from Thermotoga maritima 
       fused to the N terminus of E.coli CsgA

<400>  67

Met Met Ala Tyr Leu Val Phe Leu Gly Pro Pro Gly Ala Gly Lys Gly 
1               5                   10                  15      


Thr Tyr Ala Lys Arg Ile Gln Glu Lys Thr Gly Ile Pro His Ile Ser 
            20                  25                  30          


Thr Gly Asp Ile Phe Arg Asp Ile Val Lys Lys Glu Asn Asp Glu Leu 
        35                  40                  45              


Gly Lys Lys Ile Lys Glu Ile Met Glu Lys Gly Glu Leu Val Pro Asp 
    50                  55                  60                  


Glu Leu Val Asn Glu Val Val Lys Arg Arg Leu Ser Glu Lys Asp Cys 
65                  70                  75                  80  


Glu Lys Gly Phe Ile Leu Asp Gly Tyr Pro Arg Thr Val Ala Gln Ala 
                85                  90                  95      


Glu Phe Leu Asp Ser Phe Leu Glu Ser Gln Asn Lys Gln Leu Thr Ala 
            100                 105                 110         


Ala Val Leu Phe Asp Val Pro Glu Asp Val Val Val Gln Arg Leu Thr 
        115                 120                 125             


Ser Arg Arg Ile Cys Pro Lys Cys Gly Arg Ile Tyr Asn Met Ile Ser 
    130                 135                 140                 


Leu Pro Pro Lys Glu Asp Glu Leu Cys Asp Asp Cys Lys Val Lys Leu 
145                 150                 155                 160 


Val Gln Arg Asp Asp Asp Lys Glu Glu Thr Val Arg His Arg Tyr Lys 
                165                 170                 175     


Val Tyr Leu Glu Lys Thr Gln Pro Val Ile Asp Tyr Tyr Gly Lys Lys 
            180                 185                 190         


Gly Ile Leu Lys Arg Val Asp Gly Thr Ile Gly Ile Asp Asn Val Val 
        195                 200                 205             


Ala Glu Val Leu Lys Ile Ile Gly Trp Ser Asp Lys Gly Ser Gly Val 
    210                 215                 220                 


Val Pro Gln Tyr Gly Gly Gly Gly Asn His Gly Gly Gly Gly Asn Asn 
225                 230                 235                 240 


Ser Gly Pro Asn Ser Glu Leu Asn Ile Tyr Gln Tyr Gly Gly Gly Asn 
                245                 250                 255     


Ser Ala Leu Ala Leu Gln Thr Asp Ala Arg Asn Ser Asp Leu Thr Ile 
            260                 265                 270         


Thr Gln His Gly Gly Gly Asn Gly Ala Asp Val Gly Gln Gly Ser Asp 
        275                 280                 285             


Asp Ser Ser Ile Asp Leu Thr Gln Arg Gly Phe Gly Asn Ser Ala Thr 
    290                 295                 300                 


Leu Asp Gln Trp Asn Gly Lys Asn Ser Glu Met Thr Val Lys Gln Phe 
305                 310                 315                 320 


Gly Gly Gly Asn Gly Ala Ala Val Asp Gln Thr Ala Ser Asn Ser Ser 
                325                 330                 335     


Val Asn Val Thr Gln Val Gly Phe Gly Asn Asn Ala Thr Ala His Gln 
            340                 345                 350         


Tyr 
    


<210>  68
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of hydrophobin 3 protein from Fusarium species

<400>  68

Met Gln Phe Ser Thr Leu Thr Thr Val Phe Ala Leu Val Ala Ala Ala 
1               5                   10                  15      


Val Ala Ala Pro His Gly Ser Ser Gly Gly Asn Asn Pro Val Cys Ser 
            20                  25                  30          


Ala Gln Asn Asn Gln Val Cys Cys Asn Gly Leu Leu Ser Cys Ala Val 
        35                  40                  45              


Gln Val Leu Gly Ser Asn Cys Asn Gly Asn Ala Tyr Cys Cys Asn Thr 
    50                  55                  60                  


Glu Ala Pro Thr Gly Thr Leu Ile Asn Val Ala Leu Leu Asn Cys Val 
65                  70                  75                  80  


Lys Leu Leu 
            


<210>  69
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of hydrophobin 5 protein from Fusarium species

<400>  69

Met Lys Phe Ser Leu Ala Ala Val Ala Leu Leu Gly Ala Val Val Ser 
1               5                   10                  15      


Ala Leu Pro Ala Asn Glu Lys Arg Gln Ala Tyr Ile Pro Cys Ser Gly 
            20                  25                  30          


Leu Tyr Gly Thr Ser Gln Cys Cys Ala Thr Asp Val Leu Gly Val Ala 
        35                  40                  45              


Asp Leu Asp Cys Gly Asn Pro Pro Ser Ser Pro Thr Asp Ala Asp Asn 
    50                  55                  60                  


Phe Ser Ala Val Cys Ala Glu Ile Gly Gln Arg Ala Arg Cys Cys Val 
65                  70                  75                  80  


Leu Pro Ile Leu Asp Gln Gly Ile Leu Cys Asn Thr Pro Thr Gly Val 
                85                  90                  95      


Gln Asp 
        


<210>  70
<211>  173
<212>  PRT
<213>  Balanus albicostatus

<400>  70

Val Pro Pro Pro Cys Asp Leu Ser Ile Lys Ser Lys Leu Lys Gln Val 
1               5                   10                  15      


Gly Ala Thr Ala Gly Asn Ala Ala Val Thr Thr Thr Gly Thr Thr Ser 
            20                  25                  30          


Gly Ser Gly Val Val Lys Cys Val Val Arg Thr Pro Thr Ser Val Glu 
        35                  40                  45              


Lys Lys Ala Ala Val Gly Asn Thr Gly Leu Ser Ala Val Ser Ala Ser 
    50                  55                  60                  


Ala Ala Asn Gly Phe Phe Lys Asn Leu Gly Lys Ala Thr Thr Glu Val 
65                  70                  75                  80  


Lys Thr Thr Lys Asp Gly Thr Lys Val Lys Thr Lys Thr Ala Gly Lys 
                85                  90                  95      


Gly Lys Thr Gly Gly Thr Ala Thr Thr Ile Gln Ile Ala Asp Ala Asn 
            100                 105                 110         


Gly Gly Val Ser Glu Lys Ser Leu Lys Leu Asp Leu Leu Thr Asp Gly 
        115                 120                 125             


Leu Lys Phe Val Lys Val Thr Glu Lys Lys Gln Gly Thr Ala Thr Ser 
    130                 135                 140                 


Ser Ser Gly His Lys Ala Ser Gly Val Gly His Ser Val Phe Lys Val 
145                 150                 155                 160 


Leu Asn Glu Ala Glu Thr Glu Leu Glu Leu Lys Gly Leu 
                165                 170             


<210>  71
<211>  202
<212>  PRT
<213>  Megabalanus rosa

<400>  71

Met Lys Trp Phe Leu Phe Leu Leu Thr Thr Ala Val Leu Ala Ala Val 
1               5                   10                  15      


Val Ser Ala His Glu Glu Asp Gly Val Cys Asn Ser Asn Ala Pro Cys 
            20                  25                  30          


Tyr His Cys Asp Ala Asn Gly Glu Asn Cys Ser Cys Asn Cys Glu Leu 
        35                  40                  45              


Phe Asp Cys Glu Ala Lys Lys Pro Asp Gly Ser Tyr Ala His Pro Cys 
    50                  55                  60                  


Arg Arg Cys Asp Ala Asn Asn Ile Cys Lys Cys Ser Cys Thr Ala Ile 
65                  70                  75                  80  


Pro Cys Asn Glu Asp His Pro Cys His His Cys His Glu Glu Asp Asp 
                85                  90                  95      


Gly Asp Thr His Cys His Cys Ser Cys Glu His Ser His Asp His His 
            100                 105                 110         


Asp Asp Asp Thr His Gly Glu Cys Thr Lys Lys Ala Pro Cys Trp Arg 
        115                 120                 125             


Cys Glu Tyr Asn Ala Asp Leu Lys His Asp Val Cys Gly Cys Glu Cys 
    130                 135                 140                 


Ser Lys Leu Pro Cys Asn Asp Glu His Pro Cys Tyr Arg Lys Glu Gly 
145                 150                 155                 160 


Gly Val Val Ser Cys Asp Cys Lys Thr Ile Thr Cys Asn Glu Asp His 
                165                 170                 175     


Pro Cys Tyr His Ser Tyr Glu Glu Asp Gly Val Thr Lys Ser Asp Cys 
            180                 185                 190         


Asp Cys Glu His Ser Pro Gly Pro Ser Glu 
        195                 200         


<210>  72
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of fusion of the barnacle protein from Balanus 
       albicostatus with the adenylate kinase from Thermotgoa maritima; 
       N-terminal fusion

<400>  72

Met Arg Val Leu Val Ile Asn Ser Gly Ser Ser Ser Ile Lys Tyr Gln 
1               5                   10                  15      


Leu Ile Glu Met Glu Gly Glu Lys Val Leu Cys Lys Gly Ile Ala Glu 
            20                  25                  30          


Arg Ile Gly Ile Glu Gly Ser Arg Leu Val His Arg Val Gly Asp Glu 
        35                  40                  45              


Lys His Val Ile Glu Arg Glu Leu Pro Asp His Glu Glu Ala Leu Lys 
    50                  55                  60                  


Leu Ile Leu Asn Thr Leu Val Asp Glu Lys Leu Gly Val Ile Lys Asp 
65                  70                  75                  80  


Leu Lys Glu Ile Asp Ala Val Gly His Arg Val Val His Gly Gly Glu 
                85                  90                  95      


Arg Phe Lys Glu Ser Val Leu Val Asp Glu Glu Val Leu Lys Ala Ile 
            100                 105                 110         


Glu Glu Val Ser Pro Leu Ala Pro Leu His Asn Pro Ala Asn Leu Met 
        115                 120                 125             


Gly Ile Lys Ala Ala Met Lys Leu Leu Pro Gly Val Pro Asn Val Ala 
    130                 135                 140                 


Val Phe Asp Thr Ala Phe His Gln Thr Ile Pro Gln Lys Ala Tyr Leu 
145                 150                 155                 160 


Tyr Ala Ile Pro Tyr Glu Tyr Tyr Glu Lys Tyr Lys Ile Arg Arg Tyr 
                165                 170                 175     


Gly Phe His Gly Thr Ser His Arg Tyr Val Ser Lys Arg Ala Ala Glu 
            180                 185                 190         


Ile Leu Gly Lys Lys Leu Glu Glu Leu Lys Ile Ile Thr Cys His Ile 
        195                 200                 205             


Gly Asn Gly Ala Ser Val Ala Ala Val Lys Tyr Gly Lys Cys Val Asp 
    210                 215                 220                 


Thr Ser Met Gly Phe Thr Pro Leu Glu Gly Leu Val Met Gly Thr Arg 
225                 230                 235                 240 


Ser Gly Asp Leu Asp Pro Ala Ile Pro Phe Phe Ile Met Glu Lys Glu 
                245                 250                 255     


Gly Ile Ser Pro Gln Glu Met Tyr Asp Ile Leu Asn Lys Lys Ser Gly 
            260                 265                 270         


Val Tyr Gly Leu Ser Lys Gly Phe Ser Ser Asp Met Arg Asp Ile Glu 
        275                 280                 285             


Glu Ala Ala Leu Lys Gly Asp Glu Trp Cys Lys Leu Val Leu Glu Ile 
    290                 295                 300                 


Tyr Asp Tyr Arg Ile Ala Lys Tyr Ile Gly Ala Tyr Ala Ala Ala Met 
305                 310                 315                 320 


Asn Gly Val Asp Ala Ile Val Phe Thr Ala Gly Val Gly Glu Asn Ser 
                325                 330                 335     


Pro Ile Thr Arg Glu Asp Val Cys Ser Tyr Leu Glu Phe Leu Gly Val 
            340                 345                 350         


Lys Leu Asp Lys Gln Lys Asn Glu Glu Thr Ile Arg Gly Lys Glu Gly 
        355                 360                 365             


Ile Ile Ser Thr Pro Asp Ser Arg Val Lys Val Leu Val Val Pro Thr 
    370                 375                 380                 


Asn Glu Glu Leu Met Ile Ala Arg Asp Thr Lys Glu Ile Val Glu Lys 
385                 390                 395                 400 


Ile Gly Arg Val Pro Pro Pro Cys Asp Leu Ser Ile Lys Ser Lys Leu 
                405                 410                 415     


Lys Gln Val Gly Ala Thr Ala Gly Asn Ala Ala Val Thr Thr Thr Gly 
            420                 425                 430         


Thr Thr Ser Gly Ser Gly Val Val Lys Cys Val Val Arg Thr Pro Thr 
        435                 440                 445             


Ser Val Glu Lys Lys Ala Ala Val Gly Asn Thr Gly Leu Ser Ala Val 
    450                 455                 460                 


Ser Ala Ser Ala Ala Asn Gly Phe Phe Lys Asn Leu Gly Lys Ala Thr 
465                 470                 475                 480 


Thr Glu Val Lys Thr Thr Lys Asp Gly Thr Lys Val Lys Thr Lys Thr 
                485                 490                 495     


Ala Gly Lys Gly Lys Thr Gly Gly Thr Ala Thr Thr Ile Gln Ile Ala 
            500                 505                 510         


Asp Ala Asn Gly Gly Val Ser Glu Lys Ser Leu Lys Leu Asp Leu Leu 
        515                 520                 525             


Thr Asp Gly Leu Lys Phe Val Lys Val Thr Glu Lys Lys Gln Gly Thr 
    530                 535                 540                 


Ala Thr Ser Ser Ser Gly His Lys Ala Ser Gly Val Gly His Ser Val 
545                 550                 555                 560 


Phe Lys Val Leu Asn Glu Ala Glu Thr Glu Leu Glu Leu Lys Gly Leu 
                565                 570                 575     


<210>  73
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of fusion of barnacle protein from Balanus 
       albicostatus with the adenylate kinase from Thermotoga maritima; 
       C-terminal fusion

<400>  73

Val Pro Pro Pro Cys Asp Leu Ser Ile Lys Ser Lys Leu Lys Gln Val 
1               5                   10                  15      


Gly Ala Thr Ala Gly Asn Ala Ala Val Thr Thr Thr Gly Thr Thr Ser 
            20                  25                  30          


Gly Ser Gly Val Val Lys Cys Val Val Arg Thr Pro Thr Ser Val Glu 
        35                  40                  45              


Lys Lys Ala Ala Val Gly Asn Thr Gly Leu Ser Ala Val Ser Ala Ser 
    50                  55                  60                  


Ala Ala Asn Gly Phe Phe Lys Asn Leu Gly Lys Ala Thr Thr Glu Val 
65                  70                  75                  80  


Lys Thr Thr Lys Asp Gly Thr Lys Val Lys Thr Lys Thr Ala Gly Lys 
                85                  90                  95      


Gly Lys Thr Gly Gly Thr Ala Thr Thr Ile Gln Ile Ala Asp Ala Asn 
            100                 105                 110         


Gly Gly Val Ser Glu Lys Ser Leu Lys Leu Asp Leu Leu Thr Asp Gly 
        115                 120                 125             


Leu Lys Phe Val Lys Val Thr Glu Lys Lys Gln Gly Thr Ala Thr Ser 
    130                 135                 140                 


Ser Ser Gly His Lys Ala Ser Gly Val Gly His Ser Val Phe Lys Val 
145                 150                 155                 160 


Leu Glu Ala Glu Thr Glu Leu Glu Leu Lys Gly Leu Met Arg Val Leu 
                165                 170                 175     


Val Ile Asn Ser Gly Ser Ser Ser Ile Lys Tyr Gln Leu Ile Glu Met 
            180                 185                 190         


Glu Gly Glu Lys Val Leu Cys Lys Gly Ile Ala Glu Arg Ile Gly Ile 
        195                 200                 205             


Glu Gly Ser Arg Leu Val His Arg Val Gly Asp Glu Lys His Val Ile 
    210                 215                 220                 


Glu Arg Glu Leu Pro Asp His Glu Glu Ala Leu Lys Leu Ile Leu Asn 
225                 230                 235                 240 


Thr Leu Val Asp Glu Lys Leu Gly Val Ile Lys Asp Leu Lys Glu Ile 
                245                 250                 255     


Asp Ala Val Gly His Arg Val Val His Gly Gly Glu Arg Phe Lys Glu 
            260                 265                 270         


Ser Val Leu Val Asp Glu Glu Val Leu Lys Ala Ile Glu Glu Val Ser 
        275                 280                 285             


Pro Leu Ala Pro Leu His Asn Pro Ala Asn Leu Met Gly Ile Lys Ala 
    290                 295                 300                 


Ala Met Lys Leu Leu Pro Gly Val Pro Asn Val Ala Val Phe Asp Thr 
305                 310                 315                 320 


Ala Phe His Gln Thr Ile Pro Gln Lys Ala Tyr Leu Tyr Ala Ile Pro 
                325                 330                 335     


Tyr Glu Tyr Tyr Glu Lys Tyr Lys Ile Arg Arg Tyr Gly Phe His Gly 
            340                 345                 350         


Thr Ser His Arg Tyr Val Ser Lys Arg Ala Ala Glu Ile Leu Gly Lys 
        355                 360                 365             


Lys Leu Glu Glu Leu Lys Ile Ile Thr Cys His Ile Gly Asn Gly Ala 
    370                 375                 380                 


Ser Val Ala Ala Val Lys Tyr Gly Lys Cys Val Asp Thr Ser Met Gly 
385                 390                 395                 400 


Phe Thr Pro Leu Glu Gly Leu Val Met Gly Thr Arg Ser Gly Asp Leu 
                405                 410                 415     


Asp Pro Ala Ile Pro Phe Phe Ile Met Glu Lys Glu Gly Ile Ser Pro 
            420                 425                 430         


Gln Glu Met Tyr Asp Ile Leu Asn Lys Lys Ser Gly Val Tyr Gly Leu 
        435                 440                 445             


Ser Lys Gly Phe Ser Ser Asp Met Arg Asp Ile Glu Glu Ala Ala Leu 
    450                 455                 460                 


Lys Gly Asp Glu Trp Cys Lys Leu Val Leu Glu Ile Tyr Asp Tyr Arg 
465                 470                 475                 480 


Ile Ala Lys Tyr Ile Gly Ala Tyr Ala Ala Ala Met Asn Gly Val Asp 
                485                 490                 495     


Ala Ile Val Phe Thr Ala Gly Val Gly Glu Asn Ser Pro Ile Thr Arg 
            500                 505                 510         


Glu Asp Val Cys Ser Tyr Leu Glu Phe Leu Gly Val Lys Leu Asp Lys 
        515                 520                 525             


Gln Lys Asn Glu Glu Thr Ile Arg Gly Lys Glu Gly Ile Ile Ser Thr 
    530                 535                 540                 


Pro Asp Ser Arg Val Lys Val Leu Val Val Pro Thr Asn Glu Glu Leu 
545                 550                 555                 560 


Met Ile Ala Arg Asp Thr Lys Glu Ile Val Glu Lys Ile Gly Arg 
                565                 570                 575 


<210>  74
<211>  125
<212>  PRT
<213>  Balanus albicostatus

<400>  74

Met Lys Tyr Thr Leu Ala Leu Leu Phe Leu Thr Ala Ile Ile Ala Thr 
1               5                   10                  15      


Phe Val Ala Ala His Lys His His Asp His Gly Lys Ser Cys Ser Lys 
            20                  25                  30          


Ser His Pro Cys Tyr His Cys His Thr Asp Cys Glu Cys Asn His His 
        35                  40                  45              


His Asp Asp Cys Asn Arg Ser His Arg Cys Trp His Lys Val His Gly 
    50                  55                  60                  


Val Val Ser Gly Asn Cys Asn Cys Asn Leu Leu Thr Pro Cys Asn Gln 
65                  70                  75                  80  


Lys His Pro Cys Trp Arg Arg His Gly Lys Lys His Gly Leu His Arg 
                85                  90                  95      


Lys Phe His Gly Asn Ala Cys Asn Cys Asp Arg Leu Val Cys Asn Ala 
            100                 105                 110         


Lys His Pro Cys Trp His Lys His Cys Asp Cys Phe Cys 
        115                 120                 125 


<210>  75
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of a peptide derived from a barnacle cement 
       protein

<400>  75

Ser Lys Leu Pro Cys Asn Asp Glu His Pro Cys Tyr Arg Lys Glu Gly 
1               5                   10                  15      


Gly Val Val Ser Cys Asp Cys Lys 
            20                  


<210>  76
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of a peptide derived from a barnacle cement 
       protein

<400>  76

Ser Lys Leu Pro Ser Asn Asp Glu His Pro Ser Tyr Arg Lys Glu Gly 
1               5                   10                  15      


Gly Val Val Ser Ser Asp Ser Lys 
            20                  


<210>  77
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of a peptide derived from a barnacle cement 
       protein

<400>  77

Lys Thr Ile Thr Cys Asn Glu Asp His Pro Cys Tyr His Ser Tyr Glu 
1               5                   10                  15      


Glu Asp Gly Val Thr Lys Ser Asp Cys Asp Cys Glu 
            20                  25              


<210>  78
<211>  214
<212>  PRT
<213>  Escherichia coli

<400>  78

Met Arg Ile Ile Leu Leu Gly Ala Pro Gly Ala Gly Lys Gly Thr Gln 
1               5                   10                  15      


Ala Gln Phe Ile Met Glu Lys Tyr Gly Ile Pro Gln Ile Ser Thr Gly 
            20                  25                  30          


Asp Met Leu Arg Ala Ala Val Lys Ser Gly Ser Glu Leu Gly Lys Gln 
        35                  40                  45              


Ala Lys Asp Ile Met Asp Ala Gly Lys Leu Val Thr Asp Glu Leu Val 
    50                  55                  60                  


Ile Ala Leu Val Lys Glu Arg Ile Ala Gln Glu Asp Cys Arg Asn Gly 
65                  70                  75                  80  


Phe Leu Leu Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Asp Ala Met 
                85                  90                  95      


Lys Glu Ala Gly Ile Asn Val Asp Tyr Val Leu Glu Phe Asp Val Pro 
            100                 105                 110         


Asp Glu Leu Ile Val Asp Arg Ile Val Gly Arg Arg Val His Ala Pro 
        115                 120                 125             


Ser Gly Arg Val Tyr His Val Lys Phe Asn Pro Pro Lys Val Glu Gly 
    130                 135                 140                 


Lys Asp Asp Val Thr Gly Glu Glu Leu Thr Thr Arg Lys Asp Asp Gln 
145                 150                 155                 160 


Glu Glu Thr Val Arg Lys Arg Leu Val Glu Tyr His Gln Met Thr Ala 
                165                 170                 175     


Pro Leu Ile Gly Tyr Tyr Ser Lys Glu Ala Glu Ala Gly Asn Thr Lys 
            180                 185                 190         


Tyr Ala Lys Val Asp Gly Thr Lys Pro Val Ala Glu Val Arg Ala Asp 
        195                 200                 205             


Leu Glu Lys Ile Leu Gly 
    210                 


<210>  79
<211>  470
<212>  PRT
<213>  Escherichia coli

<400>  79

Met Lys Lys Thr Lys Ile Val Cys Thr Ile Gly Pro Lys Thr Glu Ser 
1               5                   10                  15      


Glu Glu Met Leu Ala Lys Met Leu Asp Ala Gly Met Asn Val Met Arg 
            20                  25                  30          


Leu Asn Phe Ser His Gly Asp Tyr Ala Glu His Gly Gln Arg Ile Gln 
        35                  40                  45              


Asn Leu Arg Asn Val Met Ser Lys Thr Gly Lys Thr Ala Ala Ile Leu 
    50                  55                  60                  


Leu Asp Thr Lys Gly Pro Glu Ile Arg Thr Met Lys Leu Glu Gly Gly 
65                  70                  75                  80  


Asn Asp Val Ser Leu Lys Ala Gly Gln Thr Phe Thr Phe Thr Thr Asp 
                85                  90                  95      


Lys Ser Val Ile Gly Asn Ser Glu Met Val Ala Val Thr Tyr Glu Gly 
            100                 105                 110         


Phe Thr Thr Asp Leu Ser Val Gly Asn Thr Val Leu Val Asp Asp Gly 
        115                 120                 125             


Leu Ile Gly Met Glu Val Thr Ala Ile Glu Gly Asn Lys Val Ile Cys 
    130                 135                 140                 


Lys Val Leu Asn Asn Gly Asp Leu Gly Glu Asn Lys Gly Val Asn Leu 
145                 150                 155                 160 


Pro Gly Val Ser Ile Ala Leu Pro Ala Leu Ala Glu Lys Asp Lys Gln 
                165                 170                 175     


Asp Leu Ile Phe Gly Cys Glu Gln Gly Val Asp Phe Val Ala Ala Ser 
            180                 185                 190         


Phe Ile Arg Lys Arg Ser Asp Val Ile Glu Ile Arg Glu His Leu Lys 
        195                 200                 205             


Ala His Gly Gly Glu Asn Ile His Ile Ile Ser Lys Ile Glu Asn Gln 
    210                 215                 220                 


Glu Gly Leu Asn Asn Phe Asp Glu Ile Leu Glu Ala Ser Asp Gly Ile 
225                 230                 235                 240 


Met Val Ala Arg Gly Asp Leu Gly Val Glu Ile Pro Val Glu Glu Val 
                245                 250                 255     


Ile Phe Ala Gln Lys Met Met Ile Glu Lys Cys Ile Arg Ala Arg Lys 
            260                 265                 270         


Val Val Ile Thr Ala Thr Gln Met Leu Asp Ser Met Ile Lys Asn Pro 
        275                 280                 285             


Arg Pro Thr Arg Ala Glu Ala Gly Asp Val Ala Asn Ala Ile Leu Asp 
    290                 295                 300                 


Gly Thr Asp Ala Val Met Leu Ser Gly Glu Ser Ala Lys Gly Lys Tyr 
305                 310                 315                 320 


Pro Leu Glu Ala Val Ser Ile Met Ala Thr Ile Cys Glu Arg Thr Asp 
                325                 330                 335     


Arg Val Met Asn Ser Arg Leu Glu Phe Asn Asn Asp Asn Arg Lys Leu 
            340                 345                 350         


Arg Ile Thr Glu Ala Val Cys Arg Gly Ala Val Glu Thr Ala Glu Lys 
        355                 360                 365             


Leu Asp Ala Pro Leu Ile Val Val Ala Thr Gln Gly Gly Lys Ser Ala 
    370                 375                 380                 


Arg Ala Val Arg Lys Tyr Phe Pro Asp Ala Thr Ile Leu Ala Leu Thr 
385                 390                 395                 400 


Thr Asn Glu Lys Thr Ala His Gln Leu Val Leu Ser Lys Gly Val Val 
                405                 410                 415     


Pro Gln Leu Val Lys Glu Ile Thr Ser Thr Asp Asp Phe Tyr Arg Leu 
            420                 425                 430         


Gly Lys Glu Leu Ala Leu Gln Ser Gly Leu Ala His Lys Gly Asp Val 
        435                 440                 445             


Val Val Met Val Ser Gly Ala Leu Val Pro Ser Gly Thr Thr Asn Thr 
    450                 455                 460                 


Ala Ser Val His Val Leu 
465                 470 


<210>  80
<211>  400
<212>  PRT
<213>  Escherichia coli

<400>  80

Met Ser Ser Lys Leu Val Leu Val Leu Asn Cys Gly Ser Ser Ser Leu 
1               5                   10                  15      


Lys Phe Ala Ile Ile Asp Ala Val Asn Gly Glu Glu Tyr Leu Ser Gly 
            20                  25                  30          


Leu Ala Glu Cys Phe His Leu Pro Glu Ala Arg Ile Lys Trp Lys Met 
        35                  40                  45              


Asp Gly Asn Lys Gln Glu Ala Ala Leu Gly Ala Gly Ala Ala His Ser 
    50                  55                  60                  


Glu Ala Leu Asn Phe Ile Val Asn Thr Ile Leu Ala Gln Lys Pro Glu 
65                  70                  75                  80  


Leu Ser Ala Gln Leu Thr Ala Ile Gly His Arg Ile Val His Gly Gly 
                85                  90                  95      


Glu Lys Tyr Thr Ser Ser Val Val Ile Asp Glu Ser Val Ile Gln Gly 
            100                 105                 110         


Ile Lys Asp Ala Ala Ser Phe Ala Pro Leu His Asn Pro Ala His Leu 
        115                 120                 125             


Ile Gly Ile Glu Glu Ala Leu Lys Ser Phe Pro Gln Leu Lys Asp Lys 
    130                 135                 140                 


Asn Val Ala Val Phe Asp Thr Ala Phe His Gln Thr Met Pro Glu Glu 
145                 150                 155                 160 


Ser Tyr Leu Tyr Ala Leu Pro Tyr Asn Leu Tyr Lys Glu His Gly Ile 
                165                 170                 175     


Arg Arg Tyr Gly Ala His Gly Thr Ser His Phe Tyr Val Thr Gln Glu 
            180                 185                 190         


Ala Ala Lys Met Leu Asn Lys Pro Val Glu Glu Leu Asn Ile Ile Thr 
        195                 200                 205             


Cys His Leu Gly Asn Gly Gly Ser Val Ser Ala Ile Arg Asn Gly Lys 
    210                 215                 220                 


Cys Val Asp Thr Ser Met Gly Leu Thr Pro Leu Glu Gly Leu Val Met 
225                 230                 235                 240 


Gly Thr Arg Ser Gly Asp Ile Asp Pro Ala Ile Ile Phe His Leu His 
                245                 250                 255     


Asp Thr Leu Gly Met Ser Val Asp Ala Ile Asn Lys Leu Leu Thr Lys 
            260                 265                 270         


Glu Ser Gly Leu Leu Gly Leu Thr Glu Val Thr Ser Asp Cys Arg Tyr 
        275                 280                 285             


Val Glu Asp Asn Tyr Ala Thr Lys Glu Asp Ala Lys Arg Ala Met Asp 
    290                 295                 300                 


Val Tyr Cys His Arg Leu Ala Lys Tyr Ile Gly Ala Tyr Thr Ala Leu 
305                 310                 315                 320 


Met Asp Gly Arg Leu Asp Ala Val Val Phe Thr Gly Gly Ile Gly Glu 
                325                 330                 335     


Asn Ala Ala Met Val Arg Glu Leu Ser Leu Gly Lys Leu Gly Val Leu 
            340                 345                 350         


Gly Phe Glu Val Asp His Glu Arg Asn Leu Ala Ala Arg Phe Gly Lys 
        355                 360                 365             


Ser Gly Phe Ile Asn Lys Glu Gly Thr Arg Pro Ala Val Val Ile Pro 
    370                 375                 380                 


Thr Asn Glu Glu Leu Val Ile Ala Gln Asp Ala Ser Arg Leu Thr Ala 
385                 390                 395                 400 


<210>  81
<211>  192
<212>  PRT
<213>  Methanococcus voltae

<400>  81

Met Lys Asn Lys Val Val Val Val Thr Gly Val Pro Gly Val Gly Ser 
1               5                   10                  15      


Thr Thr Ser Ser Gln Leu Ala Met Asp Asn Leu Arg Lys Glu Gly Val 
            20                  25                  30          


Asn Tyr Lys Met Val Ser Phe Gly Ser Val Met Phe Glu Val Ala Lys 
        35                  40                  45              


Glu Glu Asn Leu Val Ser Asp Arg Asp Gln Met Arg Lys Met Asp Pro 
    50                  55                  60                  


Glu Thr Gln Lys Arg Ile Gln Lys Met Ala Gly Arg Lys Ile Ala Glu 
65                  70                  75                  80  


Met Ala Lys Glu Ser Pro Val Ala Val Asp Thr His Ser Thr Val Ser 
                85                  90                  95      


Thr Pro Lys Gly Tyr Leu Pro Gly Leu Pro Ser Trp Val Leu Asn Glu 
            100                 105                 110         


Leu Asn Pro Asp Leu Ile Ile Val Val Glu Thr Thr Gly Asp Glu Ile 
        115                 120                 125             


Leu Met Arg Arg Met Ser Asp Glu Thr Arg Val Arg Asp Leu Asp Thr 
    130                 135                 140                 


Ala Ser Thr Ile Glu Gln His Gln Phe Met Asn Arg Cys Ala Ala Met 
145                 150                 155                 160 


Ser Tyr Gly Val Leu Thr Gly Ala Thr Val Lys Ile Val Gln Asn Arg 
                165                 170                 175     


Asn Gly Leu Leu Asp Gln Ala Val Glu Glu Leu Thr Asn Val Leu Arg 
            180                 185                 190         


<210>  82
<211>  192
<212>  PRT
<213>  Methanococcus thermolithotrophicus

<400>  82

Met Lys Asn Lys Leu Val Val Val Thr Gly Val Pro Gly Val Gly Gly 
1               5                   10                  15      


Thr Thr Ile Thr Gln Lys Ala Met Glu Lys Leu Ser Glu Glu Gly Ile 
            20                  25                  30          


Asn Tyr Lys Met Val Asn Phe Gly Thr Val Met Phe Glu Val Ala Gln 
        35                  40                  45              


Glu Glu Asn Leu Val Glu Asp Arg Asp Gln Met Arg Lys Leu Asp Pro 
    50                  55                  60                  


Asp Thr Gln Lys Arg Ile Gln Lys Leu Ala Gly Arg Lys Ile Ala Glu 
65                  70                  75                  80  


Met Val Lys Glu Ser Pro Val Val Val Asp Thr His Ser Thr Ile Lys 
                85                  90                  95      


Thr Pro Lys Gly Tyr Leu Pro Gly Leu Pro Val Trp Val Leu Asn Glu 
            100                 105                 110         


Leu Asn Pro Asp Ile Ile Ile Val Val Glu Thr Ser Gly Asp Glu Ile 
        115                 120                 125             


Leu Ile Arg Arg Leu Asn Asp Glu Thr Arg Asn Arg Asp Leu Glu Thr 
    130                 135                 140                 


Thr Ala Gly Ile Glu Glu His Gln Ile Met Asn Arg Ala Ala Ala Met 
145                 150                 155                 160 


Thr Tyr Gly Val Leu Thr Gly Ala Thr Val Lys Ile Ile Gln Asn Lys 
                165                 170                 175     


Asn Asn Leu Leu Asp Tyr Ala Val Glu Glu Leu Ile Ser Val Leu Arg 
            180                 185                 190         


<210>  83
<211>  217
<212>  PRT
<213>  Bacillus globisporus

<400>  83

Met Asn Ile Val Leu Met Gly Leu Pro Gly Ala Gly Lys Gly Thr Gln 
1               5                   10                  15      


Ala Asp Arg Ile Val Glu Lys Tyr Gly Thr Pro His Ile Ser Thr Gly 
            20                  25                  30          


Asp Met Phe Arg Ala Ala Ile Gln Glu Gly Thr Glu Leu Gly Val Lys 
        35                  40                  45              


Ala Lys Ser Phe Met Asp Gln Gly Ala Leu Val Pro Asp Glu Val Thr 
    50                  55                  60                  


Ile Gly Ile Val Arg Glu Arg Leu Ser Lys Ser Asp Cys Asp Asn Gly 
65                  70                  75                  80  


Phe Leu Leu Asp Gly Phe Pro Arg Thr Val Pro Gln Ala Glu Ala Leu 
                85                  90                  95      


Asp Gln Leu Leu Ala Asp Met Gly Arg Lys Ile Glu His Val Leu Asn 
            100                 105                 110         


Ile Gln Val Glu Lys Glu Glu Leu Ile Ala Arg Leu Thr Gly Arg Arg 
        115                 120                 125             


Ile Cys Lys Val Cys Gly Thr Ser Tyr His Leu Leu Phe Asn Pro Pro 
    130                 135                 140                 


Gln Val Glu Gly Lys Cys Asp Lys Asp Gly Gly Glu Leu Tyr Gln Arg 
145                 150                 155                 160 


Ala Asp Asp Asn Pro Asp Thr Val Thr Asn Arg Leu Glu Val Asn Met 
                165                 170                 175     


Asn Gln Thr Ala Pro Leu Leu Ala Phe Tyr Asp Ser Lys Glu Val Leu 
            180                 185                 190         


Val Asn Ile Asn Gly Gln Lys Asp Ile Lys Asp Val Phe Lys Asp Leu 
        195                 200                 205             


Asp Val Ile Leu Gln Gly Asn Gly Gln 
    210                 215         


<210>  84
<211>  217
<212>  PRT
<213>  Bacillus subtilis

<400>  84

Met Asn Leu Val Leu Met Gly Leu Pro Gly Ala Gly Lys Gly Thr Gln 
1               5                   10                  15      


Gly Glu Arg Ile Val Glu Asp Tyr Gly Ile Pro His Ile Ser Thr Gly 
            20                  25                  30          


Asp Met Phe Arg Ala Ala Met Lys Glu Glu Thr Pro Leu Gly Leu Glu 
        35                  40                  45              


Ala Lys Ser Tyr Ile Asp Lys Gly Glu Leu Val Pro Asp Glu Val Thr 
    50                  55                  60                  


Ile Gly Ile Val Lys Glu Arg Leu Gly Lys Asp Asp Cys Glu Arg Gly 
65                  70                  75                  80  


Phe Leu Leu Asp Gly Phe Pro Arg Thr Val Ala Gln Ala Glu Ala Leu 
                85                  90                  95      


Glu Glu Ile Leu Glu Glu Tyr Gly Lys Pro Ile Asp Tyr Val Ile Asn 
            100                 105                 110         


Ile Glu Val Asp Lys Asp Val Leu Met Glu Arg Leu Thr Gly Arg Arg 
        115                 120                 125             


Ile Cys Ser Val Cys Gly Thr Thr Tyr His Leu Val Phe Asn Pro Pro 
    130                 135                 140                 


Lys Thr Pro Gly Ile Cys Asp Lys Asp Gly Gly Glu Leu Tyr Gln Arg 
145                 150                 155                 160 


Ala Asp Asp Asn Glu Glu Thr Val Ser Lys Arg Leu Glu Val Asn Met 
                165                 170                 175     


Lys Gln Thr Gln Pro Leu Leu Asp Phe Tyr Ser Glu Lys Gly Tyr Leu 
            180                 185                 190         


Ala Asn Val Asn Gly Gln Gln Asp Ile Gln Asp Val Tyr Ala Asp Val 
        195                 200                 205             


Lys Asp Leu Leu Gly Gly Leu Lys Lys 
    210                 215         


