                         SEQUENCE LISTING

<110>  Medical College of Georgia
       Tsugio, Seki
 
<120>  SHORTENED ALK1 REGULATORY FRAGMENT

<130>  MCG 024-08

<150>  US 61/204,220
<151>  2009-01-05

<160>  7     

<170>  PatentIn version 3.3

<210>  1
<211>  4858
<212>  DNA
<213>  Artificial Squence

<220>
<223>  Synthetic 4.8 kb Alk1 gene fragment

<400>  1
gaattctttg ggcctgtttc atttcgttct gtcctcagaa tataggaaca gctgggcctt     60

gtgagcaact aattcttgta gacttggacg cagtctgtaa ttccttttct atgtcctcat    120

tggcctgagg ccctagtgct ttctccaact cttgtcactc ctcccacatc ccccgcccct    180

gccccaagct ccccgtgcac tatgggaggc ttgggttcac aagaacagcc caggcaccag    240

ccagtgtcgg aacgctaaga agaggggaaa gatgccaccc ctgtccacag cttctcttca    300

acctcctaaa ttgacttctc tccgtcttac ttcacaggcc tgcccacaga aactcttcag    360

tccccactga ccccctcagc cacttcccag ctcctgacct tacccatggt cccctatctg    420

ccccttccca aggaggcgga ccttagactt gggctgcaga ggtcccatgg gtcctgtccc    480

actcaagaca gagagccgcc ggctggagaa tgaaaggctt accggaagcc atggcatgtg    540

ggaggaagag tgggtgtgaa gatggtcatg tatccaggct ccctgttcta tagagtgtaa    600

caaagcgacc accacaatct ggaaaagcag atactgtaat ccatagtact gcaagacatg    660

gtctgtcctg accctgaaat ttggttgagc cggggctctg gaaggtcatg gggctcacaa    720

ttcaagaagc tgctagcatg tggagctcag cagaggaagt aagaccagtg ggagcctccc    780

gcctttctct cccccagcct ctatccttgc caaaggatag ggcacctctg tcccatcttg    840

caaaatctac atgacaggca tgacacctta gagattgctt ctgtgttctc ccactgggct    900

agggccaccc cttccctagc cttctcaaat attagccgac aaactccttc cttgaggaac    960

ttagataggc accatctttt accgtttgaa agatggaaca ctatgctcat tagtagcggg   1020

gggggggggg gggttgaagc ccctggaggt gttagtgggg tcacagcaac tagcctggat   1080

tcccagctgg tggaactact tcaaggtccc ccacaaggat attcacaagg ctaagagtaa   1140

aactcaagtc ctgcccagga aagcatagat tttcacccag tcccagcctg tactgccgat   1200

caggaagagg aagagtgtcc tgtcttcccc atcccgagcc ctctgcccaa ctccccagcc   1260

gcaggtccca gcctcacaag gttccatgcc ccaaattcta aagctcccca tctggtagtt   1320

gtgccccgcc cccatcccgt ggttggggtc ccatcccggc tagacaaaaa ggacacggct   1380

gaacagaaaa gacaaggtgg cctttccctc tattctggcc acccctgacc tgagggagag   1440

gaacaactaa ctgtcaagcc ttgaggtgca cagaccagac tgactcagaa cggacctatc   1500

taggtttctt tagcccgagg ctgagcgttg atggccagca ctgtggacaa cggaagggaa   1560

caaaagtatt aagggtgaag ggctggaatt tggaggcaaa aagatttaag ccaactggag   1620

aatccaaagg gcggagccaa ctctggagca gacactccca gcccaaactc agctttctta   1680

gcgctgttcc ttaggagtga gcacaggtaa gttggctgct acctcacgcg ggtccctccc   1740

tgaagccctc acgaatctag atttctgcct ctgggtgcag gctaccctct cctggcctag   1800

agcgacgctt ccgcagctag ctcagtccct acgttcctac ccaggacgca cgggacccca   1860

atgcctgggt tcgaagcctg tcccttcgtg gcagggaggg gctggggtgg tcgcactcgg   1920

tctgcagccc tctagagccg agccctgctg ctgggaggcg tactgggcaa taggaaacga   1980

gttattagga gggagtggtg gagccgggcc aggcaggaag aagctagaat aagaaacatt   2040

ttgctccagc cccttcccag tccccggagg ccgccgcgcc agccgcgcag atcaagacct   2100

ttcccggccc cacaggccgg ctctggacgt gagaccccgg ccgcctccgg caaggagagg   2160

cgggggtcga gtcgccctgt ccaaaggtga gtcggagtgc cgctgggccg ggcagggrga   2220

cctgtccctg gtctcagggg gacccttctt aaygtggatc tcaaagacct ctcagacggc   2280

gcgtggcagg gtcagtttta gccgggcaag acagtcagca gtcccctggt tgtggacaca   2340

cacctccctg ctaccccgac ctgagcgtgg aagggggcgg gtcgagcacg gatggggaat   2400

caaaaaactt tttttgctag gtatcctgag gcctttagct tctcttccct gccgagatta   2460

actcttctac ccttatctat aawggtaaaa cgggactgaa agattcttcc ctcctgagct   2520

ccagggtgct ctgttgacat aggagcgact tcccttgcgg aacctcctca tagagaccac   2580

ttaacctggc accccaatcc ttatctctat agggtcacag aattcgatga tcttcacttg   2640

gtattcccaa atctccggcc tccacagtgc tggatcacag gcatgcacta cttactgtac   2700

cccaacccag tatgtttctt gctcgtctca gacagactga atggaagcct ggaatggctg   2760

acagaccaag ggatctacct aactaaccca ctgcatgggg ttccaataca cagaaaggag   2820

gcaagttggg gaggtggaag cttgataata tgtcccagaa agatgtcttg ttgctaacta   2880

gctgactccc atctcaggta aagtctgcca ataatggctt cctgccccaa agccttggaa   2940

catgccctgt ctgcatttat ccacaaaagc ccttcggagt cctaactggc tactagctgg   3000

ggcaagaggc aggaggtcag gcagaagctg ggacacagct gcggcagtgc aggtctctat   3060

ttccttccct ggaccgggcc tctgggcaga ggaaacccag gcaggaaggc cagagcctcc   3120

actagaaagg ttcaccaaga ccctcagcct gaccctagac atcctgcccc caaaagcctc   3180

agcatcttgg gtcttcgttc agtaccaagc ttagagcacg ggcctctgtt gcataaccag   3240

tccttccagc ctaccggtgt cttctcacat gtgttggctc cctcactggg gatccagcct   3300

gcacactctg ccattcagaa agtctgtgtt cctgtttgac cccggtccct cttgctacag   3360

gctcagcact gtcttctggc tctgaggctt tgagaaggga agggtggtat agcttctgaa   3420

acgatagctg atttgggccc cgggttgagg gctatcacat cataccagaa tcacgactct   3480

taccagtgcc catcagactt ctggaagaac aaaaccctag gcaagagtga agcccaggca   3540

actctctgag gtcaaacact cggtgtctaa gtatgtttca cttcctgtac tactggccct   3600

ccccccagcc ctttcccagg acaatgagaa gagagaaggg ggcccagatg gctttgaagg   3660

agaaacagac cttttatacg atgtgctata agcctgggga tgcaggtagg gactgacccc   3720

acccgctcag gacacagaga agaaagacca gtttggggag atggagtcta gagagggtac   3780

agcattcact ctgtaaccct ggctgtcctg gaactcactc tgtagaccag gctggcctcg   3840

gactcagaaa tccgcctgcc tctgcctctc aagtgctggg attaaaggcg tgtaccacca   3900

ctgcccgtct ggggtctaga ctcttgtgtt agactcctgt tactaatgga atctgacaag   3960

cctcccctgg atgaggctta ctctctcctt taagaccaga gctgcagggg agggccacga   4020

agagatgata cagcaggtaa tgatgcttgc tacgtaagct gggtgacctg agttcgatct   4080

ccagcgccca cgtaaaggcg gaaggagaaa aacagctgca cagaattatc tctgactttc   4140

acacttgtac cttagcacga agacccttac agacagaccc agtaataatg aatacattta   4200

aaacaacaaa accccccaga gctgtgtaag gtacctacac agacgtcaca cagttgtctc   4260

tgctcctggt ggtcccttta aaccccgtcc tgcttccagc ctgccctgag ctccctgctg   4320

tgcgtgactt cagcctgttc tatccaggcc tcaatctaaa caatcttgat tcctgttgcc   4380

ggcctggcgg gaccctgaat ggcaggaagt aaggacaaga gcctgtttat gtttgaagca   4440

gccaggctgg gggtggggag tgggggcact gggaaacggt gggcaggggt ggaggctgga   4500

gcgatgggca aacggctgag gacaagagat gagctatgag agagtcgtcc ttcccactgt   4560

agctctgtct gtctgcaacc ctcccggcct attaccctct gaacagttgc agtgggcaca   4620

gagccccggt cctctctggc tctcttcatt taaacacagt tctccaccct ttacccccaa   4680

cagatggttt ccatggggaa gtgaaccagg acttcccttg caggccccgc cctaaagtca   4740

gacgtaggag ttgggaggtg gcttccctgc ctccccccac cccccaaaaa aaacctcaca   4800

gtgatttcct ctggtaggag gagaccttgg tcaccacagc tatcacgttt tgcagatc     4858


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic conserved region of ICE-Like caspaces

<400>  2

Gln Ala Cys Lys Gly 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polylinker

<400>  3

Gly Gly Gly Gly Ser 
1               5   


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polylinker

<400>  4

Glu Gly Leu Ser Ser Gly Ser Gly Ser Glu Ser Leu Val Asp 
1               5                   10                  


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polylinker

<400>  5

Leu Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Arg 
        


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic  forward primer in Alk1 intron 2 sequence

<400>  6
agtgaaccag gacttccctt gcag                                            24


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic reverse primer in SD/SA sequence

<400>  7
cgggtacaat tccgcagctt ttag                                            24


