                         SEQUENCE LISTING

<110>  Bristol-Myers Squibb Company
 
<120>  METHODS OF INHIBITING QUIESCENT TUMOR PROLIFERATION

<130>  11355 PCT

<150>  US 61/201913
<151>  2008-12-16

<160>  114   

<170>  PatentIn version 3.5

<210>  1
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Thr Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Gly Asn Leu Phe Gln Arg Trp His Val Pro Leu Glu Leu 
        35                  40                  45              


Gln Met Thr Arg Gln Met Ala Ser Ser Gly Ala Ser Gly Gly Lys Ile 
    50                  55                  60                  


Asp Asn Ser Val Leu Val Leu Ile Val Gly Leu Ser Thr Val Gly Ala 
65                  70                  75                  80  


Gly Ala Tyr Ala Tyr Lys Thr Met Lys Glu Asp Glu Lys Arg Tyr Asn 
                85                  90                  95      


Glu Arg Ile Ser Gly Leu Gly Leu Thr Pro Glu Gln Lys Gln Lys Lys 
            100                 105                 110         


Ala Ala Leu Ser Ala Ser Glu Gly Glu Glu Val Pro Gln Asp Lys Ala 
        115                 120                 125             


Pro Ser His Val Pro Phe Leu Leu Ile Gly Gly Gly Thr Ala Ala Phe 
    130                 135                 140                 


Ala Ala Ala Arg Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu 
145                 150                 155                 160 


Ile Val Ser Glu Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser 
                165                 170                 175     


Lys Glu Leu Trp Phe Ser Asp Asp Pro Asn Val Thr Lys Thr Leu Arg 
            180                 185                 190         


Phe Lys Gln Trp Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro 
        195                 200                 205             


Ser Phe Tyr Val Ser Ala Gln Asp Leu Pro His Ile Glu Asn Gly Gly 
    210                 215                 220                 


Val Ala Val Leu Thr Gly Lys Lys Val Val Gln Leu Asp Val Arg Asp 
225                 230                 235                 240 


Asn Met Val Lys Leu Asn Asp Gly Ser Gln Ile Thr Tyr Glu Lys Cys 
                245                 250                 255     


Leu Ile Ala Thr Gly Gly Thr Pro Arg Ser Leu Ser Ala Ile Asp Arg 
            260                 265                 270         


Ala Gly Ala Glu Val Lys Ser Arg Thr Thr Leu Phe Arg Lys Ile Gly 
        275                 280                 285             


Asp Phe Arg Ser Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Thr 
    290                 295                 300                 


Ile Ile Gly Gly Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly 
305                 310                 315                 320 


Arg Lys Ala Arg Ala Leu Gly Thr Glu Val Ile Gln Leu Phe Pro Glu 
                325                 330                 335     


Lys Gly Asn Met Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Thr 
            340                 345                 350         


Met Glu Lys Val Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile 
        355                 360                 365             


Val Gln Ser Val Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys 
    370                 375                 380                 


Asp Gly Arg Lys Val Glu Thr Asp His Ile Val Ala Ala Val Gly Leu 
385                 390                 395                 400 


Glu Pro Asn Val Glu Leu Ala Lys Thr Gly Gly Leu Glu Ile Asp Ser 
                405                 410                 415     


Asp Phe Gly Gly Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn 
            420                 425                 430         


Ile Trp Val Ala Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly 
        435                 440                 445             


Arg Arg Arg Val Glu His His Asp His Ala Val Val Ser Gly Arg Leu 
    450                 455                 460                 


Ala Gly Glu Asn Met Thr Gly Ala Ala Lys Pro Tyr Trp His Gln Ser 
465                 470                 475                 480 


Met Phe Trp Ser Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly 
                485                 490                 495     


Leu Val Asp Ser Ser Leu Pro Thr Val Gly Val Phe Ala Lys Ala Thr 
            500                 505                 510         


Ala Gln Asp Asn Pro Lys Ser Ala Thr Glu Gln Ser Gly Thr Gly Ile 
        515                 520                 525             


Arg Ser Glu Ser Glu Thr Glu Ser Glu Ala Ser Glu Ile Thr Ile Pro 
    530                 535                 540                 


Pro Ser Thr Pro Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr 
545                 550                 555                 560 


Gly Lys Gly Val Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile 
                565                 570                 575     


Val Leu Trp Asn Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile 
            580                 585                 590         


Lys Asp Gly Glu Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe 
        595                 600                 605             


Asn Ile His Glu Asp 
    610             


<210>  2
<211>  612
<212>  PRT
<213>  Mus musculus

<400>  2

Met Phe Arg Cys Gly Gly Leu Ala Gly Ala Phe Lys Gln Lys Leu Val 
1               5                   10                  15      


Pro Leu Val Arg Thr Val Tyr Val Gln Arg Pro Lys Gln Arg Asn Arg 
            20                  25                  30          


Leu Pro Gly Asn Leu Phe Gln Gln Trp Arg Val Pro Leu Glu Leu Gln 
        35                  40                  45              


Met Ala Arg Gln Met Ala Ser Ser Gly Ser Ser Gly Gly Lys Met Asp 
    50                  55                  60                  


Asn Ser Val Leu Val Leu Ile Val Gly Leu Ser Thr Ile Gly Ala Gly 
65                  70                  75                  80  


Ala Tyr Ala Tyr Lys Thr Ile Lys Glu Asp Gln Lys Arg Tyr Asn Glu 
                85                  90                  95      


Arg Val Met Gly Leu Gly Leu Ser Pro Glu Glu Lys Gln Arg Arg Ala 
            100                 105                 110         


Ile Ala Ser Ala Thr Glu Gly Gly Ser Val Pro Gln Ile Arg Ala Pro 
        115                 120                 125             


Ser His Val Pro Phe Leu Leu Ile Gly Gly Gly Thr Ala Ala Phe Ala 
    130                 135                 140                 


Ala Ala Arg Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu Ile 
145                 150                 155                 160 


Val Ser Glu Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser Lys 
                165                 170                 175     


Glu Leu Trp Phe Ser Asp Asp Pro Asn Val Thr Lys Thr Leu Gln Phe 
            180                 185                 190         


Arg Gln Trp Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro Ser 
        195                 200                 205             


Phe Tyr Val Ser Ala Gln Asp Leu Pro Asn Ile Glu Asn Gly Gly Val 
    210                 215                 220                 


Ala Val Leu Thr Gly Lys Lys Val Val His Leu Asp Val Arg Gly Asn 
225                 230                 235                 240 


Met Val Lys Leu Asn Asp Gly Ser Gln Ile Thr Phe Glu Lys Cys Leu 
                245                 250                 255     


Ile Ala Thr Gly Gly Thr Pro Arg Ser Leu Ser Ala Ile Asp Arg Ala 
            260                 265                 270         


Gly Ala Glu Val Lys Ser Arg Thr Thr Leu Phe Arg Lys Ile Gly Asp 
        275                 280                 285             


Phe Arg Ala Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Thr Val 
    290                 295                 300                 


Ile Gly Gly Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly Arg 
305                 310                 315                 320 


Lys Ser Gln Ala Ser Gly Ile Glu Val Ile Gln Leu Phe Pro Glu Lys 
                325                 330                 335     


Gly Asn Met Gly Lys Ile Leu Pro Gln Tyr Leu Ser Asn Trp Thr Met 
            340                 345                 350         


Glu Lys Val Lys Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile Val 
        355                 360                 365             


Gln Ser Val Gly Val Ser Gly Gly Arg Leu Leu Ile Lys Leu Lys Asp 
    370                 375                 380                 


Gly Arg Lys Val Glu Thr Asp His Ile Val Thr Ala Val Gly Leu Glu 
385                 390                 395                 400 


Pro Asn Val Glu Leu Ala Lys Thr Gly Gly Leu Glu Ile Asp Ser Asp 
                405                 410                 415     


Phe Gly Gly Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn Ile 
            420                 425                 430         


Trp Val Ala Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly Arg 
        435                 440                 445             


Arg Arg Val Glu His His Asp His Ala Val Val Ser Gly Arg Leu Ala 
    450                 455                 460                 


Gly Glu Asn Met Thr Gly Ala Ala Lys Pro Tyr Trp His Gln Ser Met 
465                 470                 475                 480 


Phe Trp Ser Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly Leu 
                485                 490                 495     


Val Asp Ser Ser Leu Pro Thr Val Gly Val Phe Ala Lys Ala Thr Ala 
            500                 505                 510         


Gln Asp Asn Pro Lys Ser Ala Thr Glu Gln Ser Gly Thr Gly Ile Arg 
        515                 520                 525             


Ser Glu Ser Glu Thr Glu Ser Glu Ala Ser Glu Ile Thr Ile Pro Pro 
    530                 535                 540                 


Ser Ala Pro Ala Val Pro Gln Val Pro Val Glu Gly Glu Asp Tyr Gly 
545                 550                 555                 560 


Lys Gly Val Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile Val 
                565                 570                 575     


Leu Trp Asn Val Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile Lys 
            580                 585                 590         


Asp Gly Glu Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe Asn 
        595                 600                 605             


Ile His Glu Asp 
    610         


<210>  3
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Asn His Val Ala Ile Ile Gly Asn Gly Val Ala Gly Phe Thr 
1               5                   10                  15      


Thr Ala Gln Ala Leu Arg Ala Glu Gly Tyr Glu Gly Arg Ile Ser Leu 
            20                  25                  30          


Ile Gly Glu Glu Gln His Leu Pro Tyr Asp Arg Pro Ser Leu Ser Lys 
        35                  40                  45              


Ala Val Leu Asp Gly Ser Phe Glu Gln Pro Pro Arg Leu Ala Glu Ala 
    50                  55                  60                  


Asp Trp Tyr Ser Glu Ala Ser Ile Glu Met Leu Thr Gly Ser Glu Val 
65                  70                  75                  80  


Thr Asp Leu Asp Thr Gln Lys Lys Met Ile Ser Leu Asn Asp Gly Ser 
                85                  90                  95      


Thr Ile Ser Ala Asp Ala Ile Val Ile Ala Thr Gly Ser Arg Ala Arg 
            100                 105                 110         


Met Leu Ser Leu Pro Gly Ser Gln Leu Pro Gly Val Val Thr Leu Arg 
        115                 120                 125             


Thr Tyr Gly Asp Val Gln Leu Leu Arg Asp Ser Trp Thr Pro Asn Thr 
    130                 135                 140                 


Arg Leu Leu Ile Val Gly Gly Gly Leu Ile Gly Cys Glu Val Ala Thr 
145                 150                 155                 160 


Thr Ala Arg Lys Leu Gly Leu Ser Val Thr Ile Leu Glu Ala Gly Asp 
                165                 170                 175     


Glu Leu Leu Val Arg Val Leu Gly Arg Arg Ile Gly Ala Trp Leu Arg 
            180                 185                 190         


Gly Leu Leu Thr Glu Gln Gly Val Gln Val Glu Leu Lys Thr Gly Val 
        195                 200                 205             


Ser Gly Phe Ser Gly Glu Gly Gln Leu Glu Lys Val Met Val Asn Asp 
    210                 215                 220                 


Gly Arg Ser Phe Ile Ala Asp Asn Ala Leu Ile Cys Val Gly Ala Asp 
225                 230                 235                 240 


Pro Ala Asp Gln Leu Ala Arg Gln Ala Gly Leu Glu Cys Asp Arg Gly 
                245                 250                 255     


Val Val Val Asp His Arg Gly Ala Thr Ser Ala Lys Gly Ile Phe Ala 
            260                 265                 270         


Val Gly Asp Val Ala Thr Trp Pro Leu His Ser Gly Gly Lys Arg Ser 
        275                 280                 285             


Leu Glu Thr Tyr Met Asn Ala Gln Arg Gln Ala Thr Ala Val Ala Lys 
    290                 295                 300                 


Ala Ile Leu Gly Lys Glu Val Ser Ala Pro Gln Leu Pro Val Ser Trp 
305                 310                 315                 320 


Thr Glu Ile Ala Gly His Arg Met Gln Met Ala Gly Asp Ile Glu Gly 
                325                 330                 335     


Pro Gly Glu Tyr Val Leu Arg Gly Thr Leu Gly Ile Gly Ser Ala Leu 
            340                 345                 350         


Leu Phe Arg Leu Leu Asp Gly Arg Ile Gln Ala Val Val Ala Val Asp 
        355                 360                 365             


Ala Pro Arg Asp Phe Ala Leu Ala Asn Arg Leu Val Glu Ala Gln Val 
    370                 375                 380                 


Ile Ile Glu Pro Glu Lys Leu Ala Asp Val Ser Asn Asn Met Arg Asp 
385                 390                 395                 400 


Ile Val Arg Ala Asn Glu Gly Asn Gln Lys 
                405                 410 


<210>  4
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Gln Val Asn Glu Leu Lys Glu Lys Gly Asn Lys Ala Leu Ser 
1               5                   10                  15      


Val Gly Asn Ile Asp Asp Ala Leu Gln Cys Tyr Ser Glu Ala Ile Lys 
            20                  25                  30          


Leu Asp Pro His Asn His Val Leu Tyr Ser Asn Arg Ser Ala Ala Tyr 
        35                  40                  45              


Ala Lys Lys Gly Asp Tyr Gln Lys Ala Tyr Glu Asp Gly Cys Lys Thr 
    50                  55                  60                  


Val Asp Leu Lys Pro Asp Trp Gly Lys Gly Tyr Ser Arg Lys Ala Ala 
65                  70                  75                  80  


Ala Leu Glu Phe Leu Asn Arg Phe Glu Glu Ala Lys Arg Thr Tyr Glu 
                85                  90                  95      


Glu Gly Leu Lys His Glu Ala Asn Asn Pro Gln Leu Lys Glu Gly Leu 
            100                 105                 110         


Gln Asn Met Glu Ala Arg Leu Ala Glu Arg Lys Phe Met Asn Pro Phe 
        115                 120                 125             


Asn Met Pro Asn Leu Tyr Gln Lys Leu Glu Ser Asp Pro Arg Thr Arg 
    130                 135                 140                 


Thr Leu Leu Ser Asp Pro Thr Tyr Arg Glu Leu Ile Glu Gln Leu Arg 
145                 150                 155                 160 


Asn Lys Pro Ser Asp Leu Gly Thr Lys Leu Gln Asp Pro Arg Ile Met 
                165                 170                 175     


Thr Thr Leu Ser Val Leu Leu Gly Val Asp Leu Gly Ser Met Asp Glu 
            180                 185                 190         


Glu Glu Glu Ile Ala Thr Pro Pro Pro Pro Pro Pro Pro Lys Lys Glu 
        195                 200                 205             


Thr Lys Pro Glu Pro Met Glu Glu Asp Leu Pro Glu Asn Lys Lys Gln 
    210                 215                 220                 


Ala Leu Lys Glu Lys Glu Leu Gly Asn Asp Ala Tyr Lys Lys Lys Asp 
225                 230                 235                 240 


Phe Asp Thr Ala Leu Lys His Tyr Asp Lys Ala Lys Glu Leu Asp Pro 
                245                 250                 255     


Thr Asn Met Thr Tyr Ile Thr Asn Gln Ala Ala Val Tyr Phe Glu Lys 
            260                 265                 270         


Gly Asp Tyr Asn Lys Cys Arg Glu Leu Cys Glu Lys Ala Ile Glu Val 
        275                 280                 285             


Gly Arg Glu Asn Arg Glu Asp Tyr Arg Gln Ile Ala Lys Ala Tyr Ala 
    290                 295                 300                 


Arg Ile Gly Asn Ser Tyr Phe Lys Glu Glu Lys Tyr Lys Asp Ala Ile 
305                 310                 315                 320 


His Phe Tyr Asn Lys Ser Leu Ala Glu His Arg Thr Pro Asp Val Leu 
                325                 330                 335     


Lys Lys Cys Gln Gln Ala Glu Lys Ile Leu Lys Glu Gln Glu Arg Leu 
            340                 345                 350         


Ala Tyr Ile Asn Pro Asp Leu Ala Leu Glu Glu Lys Asn Lys Gly Asn 
        355                 360                 365             


Glu Cys Phe Gln Lys Gly Asp Tyr Pro Gln Ala Met Lys His Tyr Thr 
    370                 375                 380                 


Glu Ala Ile Lys Arg Asn Pro Lys Asp Ala Lys Leu Tyr Ser Asn Arg 
385                 390                 395                 400 


Ala Ala Cys Tyr Thr Lys Leu Leu Glu Phe Gln Leu Ala Leu Lys Asp 
                405                 410                 415     


Cys Glu Glu Cys Ile Gln Leu Glu Pro Thr Phe Ile Lys Gly Tyr Thr 
            420                 425                 430         


Arg Lys Ala Ala Ala Leu Glu Ala Met Lys Asp Tyr Thr Lys Ala Met 
        435                 440                 445             


Asp Val Tyr Gln Lys Ala Leu Asp Leu Asp Ser Ser Cys Lys Glu Ala 
    450                 455                 460                 


Ala Asp Gly Tyr Gln Arg Cys Met Met Ala Gln Tyr Asn Arg His Asp 
465                 470                 475                 480 


Ser Pro Glu Asp Val Lys Arg Arg Ala Met Ala Asp Pro Glu Val Gln 
                485                 490                 495     


Gln Ile Met Ser Asp Pro Ala Met Arg Leu Ile Leu Glu Gln Met Gln 
            500                 505                 510         


Lys Asp Pro Gln Ala Leu Ser Glu His Leu Lys Asn Pro Val Ile Ala 
        515                 520                 525             


Gln Lys Ile Gln Lys Leu Met Asp Val Gly Leu Ile Ala Ile Arg 
    530                 535                 540             


<210>  5
<211>  546
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Ala Tyr Leu Ser Gln Pro Asn Thr Val Lys Cys Ser Gly Asp 
1               5                   10                  15      


Gly Val Gly Ala Pro Arg Leu Pro Leu Pro Tyr Gly Phe Ser Ala Met 
            20                  25                  30          


Gln Gly Trp Arg Val Ser Met Glu Asp Ala His Asn Cys Ile Pro Glu 
        35                  40                  45              


Leu Asp Ser Glu Thr Ala Met Phe Ser Val Tyr Asp Gly His Gly Gly 
    50                  55                  60                  


Glu Glu Val Ala Leu Tyr Cys Ala Lys Tyr Leu Pro Asp Ile Ile Lys 
65                  70                  75                  80  


Asp Gln Lys Ala Tyr Lys Glu Gly Lys Leu Gln Lys Ala Leu Glu Asp 
                85                  90                  95      


Ala Phe Leu Ala Ile Asp Ala Lys Leu Thr Thr Glu Glu Val Ile Lys 
            100                 105                 110         


Glu Leu Ala Gln Ile Ala Gly Arg Pro Thr Glu Asp Glu Asp Glu Lys 
        115                 120                 125             


Glu Lys Val Ala Asp Glu Asp Asp Val Asp Asn Glu Glu Ala Ala Leu 
    130                 135                 140                 


Leu His Glu Glu Ala Thr Met Thr Ile Glu Glu Leu Leu Thr Arg Tyr 
145                 150                 155                 160 


Gly Gln Asn Cys His Lys Gly Pro Pro His Ser Lys Ser Gly Gly Gly 
                165                 170                 175     


Thr Gly Glu Glu Pro Gly Ser Gln Gly Leu Asn Gly Glu Ala Gly Pro 
            180                 185                 190         


Glu Asp Ser Thr Arg Glu Thr Pro Ser Gln Glu Asn Gly Pro Thr Ala 
        195                 200                 205             


Lys Ala Tyr Thr Gly Phe Ser Ser Asn Ser Glu Arg Gly Thr Glu Ala 
    210                 215                 220                 


Gly Gln Val Gly Glu Pro Gly Ile Pro Thr Gly Glu Ala Gly Pro Ser 
225                 230                 235                 240 


Cys Ser Ser Ala Ser Asp Lys Leu Pro Arg Val Ala Lys Ser Lys Phe 
                245                 250                 255     


Phe Glu Asp Ser Glu Asp Glu Ser Asp Glu Ala Glu Glu Glu Glu Glu 
            260                 265                 270         


Asp Ser Glu Glu Cys Ser Glu Glu Glu Asp Gly Tyr Ser Ser Glu Glu 
        275                 280                 285             


Ala Glu Asn Glu Glu Asp Glu Asp Asp Thr Glu Glu Ala Glu Glu Asp 
    290                 295                 300                 


Asp Glu Glu Glu Glu Glu Glu Met Met Val Pro Gly Met Glu Gly Lys 
305                 310                 315                 320 


Glu Glu Pro Gly Ser Asp Ser Gly Thr Thr Ala Val Val Ala Leu Ile 
                325                 330                 335     


Arg Gly Lys Gln Leu Ile Val Ala Asn Ala Gly Asp Ser Arg Cys Val 
            340                 345                 350         


Val Ser Glu Ala Gly Lys Ala Leu Asp Met Ser Tyr Asp His Lys Pro 
        355                 360                 365             


Glu Asp Glu Val Glu Leu Ala Arg Ile Lys Asn Ala Gly Gly Lys Val 
    370                 375                 380                 


Thr Met Asp Gly Arg Val Asn Gly Gly Leu Asn Leu Ser Arg Ala Ile 
385                 390                 395                 400 


Gly Asp His Phe Tyr Lys Arg Asn Lys Asn Leu Pro Pro Glu Glu Gln 
                405                 410                 415     


Met Ile Ser Ala Leu Pro Asp Ile Lys Val Leu Thr Leu Thr Asp Asp 
            420                 425                 430         


His Glu Phe Met Val Ile Ala Cys Asp Gly Ile Trp Asn Val Met Ser 
        435                 440                 445             


Ser Gln Glu Val Val Asp Phe Ile Gln Ser Lys Ile Ser Gln Arg Asp 
    450                 455                 460                 


Glu Asn Gly Glu Leu Arg Leu Leu Ser Ser Ile Val Glu Glu Leu Leu 
465                 470                 475                 480 


Asp Gln Cys Leu Ala Pro Asp Thr Ser Gly Asp Gly Thr Gly Cys Asp 
                485                 490                 495     


Asn Met Thr Cys Ile Ile Ile Cys Phe Lys Pro Arg Asn Thr Ala Glu 
            500                 505                 510         


Leu Gln Pro Glu Ser Gly Lys Arg Lys Leu Glu Glu Val Leu Ser Thr 
        515                 520                 525             


Glu Gly Ala Glu Glu Asn Gly Asn Ser Asp Lys Lys Lys Lys Ala Lys 
    530                 535                 540                 


Arg Asp 
545     


<210>  6
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Ser Arg Gly Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala 
1               5                   10                  15      


Glu Thr Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg 
            20                  25                  30          


Pro Ser Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly 
        35                  40                  45              


Asp Gln Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp 
    50                  55                  60                  


Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr 
65                  70                  75                  80  


Tyr Thr Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile 
                85                  90                  95      


His Leu Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp 
            100                 105                 110         


Tyr His Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala 
        115                 120                 125             


Lys Gly Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro 
    130                 135                 140                 


Gly Asp Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro 
145                 150                 155                 160 


Gly Ser Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly 
                165                 170                 175     


Arg Tyr Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu 
            180                 185                 190         


Val Glu His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe 
        195                 200                 205             


Val Tyr Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp 
    210                 215                 220                 


Ile Glu Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln 
                245                 250                 255     


Glu Val Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn 
            260                 265                 270         


Lys Gly Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg 
        275                 280                 285             


Val Ile Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile 
    290                 295                 300                 


Asn Ala Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala 
305                 310                 315                 320 


Lys Thr Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp 
                325                 330                 335     


Phe Trp Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr 
            340                 345                 350         


Thr Arg Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro 
        355                 360                 365             


Glu Val Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys 
    370                 375                 380                 


Gly Glu His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser 
385                 390                 395                 400 


Pro Leu Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr 
                405                 410                 415     


Leu Ser Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu 
            420                 425                 430         


Ser Phe Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala 
        435                 440                 445             


Gly Pro Ile Ile Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr 
    450                 455                 460                 


Ile Ile Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu 
465                 470                 475                 480 


Asp Cys Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln 
                485                 490                 495     


Arg Ser Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val 
            500                 505                 510         


Ala Ile Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu 
        515                 520                 525             


Gln Ser Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro 
    530                 535                 540                 


Pro Ala Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys 
545                 550                 555                 560 


His Lys Glu Asp Val Tyr Glu Asn Leu His Thr Lys Asn Lys Arg Glu 
                565                 570                 575     


Glu Lys Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Lys Ser Lys Gly 
            580                 585                 590         


Ser Leu Lys Arg Lys 
        595         


<210>  7
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Asn Asp Gly Ser Gln Ile Thr Tyr Glu Lys 
1               5                   10      


<210>  8
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Leu Gly Thr Glu Val Ile Gln Leu Phe Pro Glu Lys 
1               5                   10              


<210>  9
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Leu Ser Val Gly Asn Ile Asp Asp Ala Leu Gln Cys Tyr Ser Glu 
1               5                   10                  15      


Ala Ile Lys 
            


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Ala Ala Leu Glu Phe Leu Asn Arg 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

His Glu Ala Asn Asn Pro Gln Leu Lys 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Gly Leu Gln Asn Met Glu Ala Arg 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Thr Leu Leu Ser Asp Pro Thr Tyr Arg 
1               5                   


<210>  14
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Leu Ile Glu Gln Leu Arg 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Asn Lys Pro Ser Asp Leu Gly Thr Lys 
1               5                   


<210>  16
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Leu Gly Asn Asp Ala Tyr Lys 
1               5               


<210>  17
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  17

Asp Phe Asp Thr Ala Leu Lys 
1               5           


<210>  18
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  18

Leu Ala Tyr Ile Asn Pro Asp Leu Ala Leu Glu Glu Lys 
1               5                   10              


<210>  19
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Cys Glu Glu Cys Ile Gln Leu Glu Pro Thr Phe Ile Lys 
1               5                   10                  


<210>  20
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Met Asp Val Tyr Gln Lys 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Leu Asp Leu Asp Ser Ser Cys Lys 
1               5                   


<210>  22
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Ala Ala Asp Gly Tyr Gln Arg 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  23

Leu Ile Leu Glu Gln Met Gln Lys 
1               5               


<210>  24
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Pro Gln Ala Leu Ser Glu His Leu Lys 
1               5                   10  


<210>  25
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  25

Asn Pro Val Ile Ala Gln Lys 
1               5           


<210>  26
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  26

Leu Met Asp Val Gly Leu Ile Ala Ile Arg 
1               5                   10  


<210>  27
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  27

Leu Thr Thr Glu Glu Val Ile Lys 
1               5               


<210>  28
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Leu Ala Gln Ile Ala Gly Arg Pro Thr Glu Asp Glu Asp Glu Lys 
1               5                   10                  15      


<210>  29
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Glu Pro Gly Ser Asp Ser Gly Thr Thr Ala Val Val Ala Leu Ile 
1               5                   10                  15      


Arg 
    


<210>  30
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Leu Ile Val Ala Asn Ala Gly Asp Ser Arg 
1               5                   10      


<210>  31
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  31

Asp Leu Ser Gly Leu Asp Ala Glu Thr Leu Leu Lys 
1               5                   10          


<210>  32
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  32

Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr Leu Arg 
1               5                   10                  


<210>  33
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  33

Val Asn Ala Ala Asp Ile Glu Asn Arg 
1               5                   


<210>  34
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Ile Lys 
1               5                   10                  15      


<210>  35
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  35

Thr Leu Gln Val Ser Pro Leu Asp Asn Gly Asp Leu Ile Arg 
1               5                   10                  


<210>  36
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  36

Gly Leu Asp Cys Asp Ile Asp Ile Gln Lys 
1               5                   10  


<210>  37
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Asp Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  38
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  38

Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg 
1               5                   10      


<210>  39
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  39

Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu Arg 
1               5                   10              


<210>  40
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  40

Asn Gln Val Ala Leu Asn Pro Gln Asn Thr Val Phe Asp Ala Lys 
1               5                   10                  15  


<210>  41
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
1               5                   10                  15      


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg 
            20                  25          


<210>  42
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  42

Asp Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg 
1               5                   10          


<210>  43
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  43

Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg 
1               5                   10                  15      


<210>  44
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  44

Phe Glu Glu Leu Cys Ser Asp Leu Phe Arg 
1               5                   10  


<210>  45
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  45

Leu Leu Gln Asp Phe Phe Asn Gly Arg 
1               5                   


<210>  46
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  46

Ser Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala 
1               5                   10                  15      


Ala Ile Leu Met Gly Asp Lys 
            20              


<210>  47
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  47

Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
1               5                   10                  15      


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys 
            20                  25                  30      


<210>  48
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Thr Gln Ile Phe Thr Thr Tyr Ser Asp Asn Gln Pro Gly Val Leu 
1               5                   10                  15      


Ile Gln Val Tyr Glu Gly Glu Arg 
            20                  


<210>  49
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ser Ala Arg Gly Pro Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr 
1               5                   10                  15      


Ser Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn 
            20                  25                  30          


Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr 
        35                  40                  45              


Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro 
    50                  55                  60                  


Thr Asn Thr Ile Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Glu 
65                  70                  75                  80  


Asp Ala Thr Val Gln Ser Asp Met Lys His Trp Pro Phe Arg Val Val 
                85                  90                  95      


Ser Glu Gly Gly Lys Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr 
            100                 105                 110         


Lys Thr Phe Phe Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met 
        115                 120                 125             


Lys Glu Ile Ala Glu Ala Tyr Leu Gly Gly Lys Val His Ser Ala Val 
    130                 135                 140                 


Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys 
145                 150                 155                 160 


Asp Ala Gly Thr Ile Thr Gly Leu Asn Val Leu Arg Ile Ile Asn Glu 
                165                 170                 175     


Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Gly Cys Ala 
            180                 185                 190         


Gly Gly Glu Lys Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe 
        195                 200                 205             


Asp Val Ser Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser 
    210                 215                 220                 


Thr Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met 
225                 230                 235                 240 


Val Ser His Leu Ala Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile 
                245                 250                 255     


Gly Pro Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg 
            260                 265                 270         


Ala Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp 
        275                 280                 285             


Ser Leu Tyr Glu Gly Val Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg 
    290                 295                 300                 


Phe Glu Glu Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Glu Pro Val 
305                 310                 315                 320 


Glu Lys Ala Leu Arg Asp Ala Lys Leu Asp Lys Gly Gln Ile Gln Glu 
                325                 330                 335     


Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu 
            340                 345                 350         


Leu Gln Asp Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro 
        355                 360                 365             


Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ile 
    370                 375                 380                 


Gly Asp Lys Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr 
385                 390                 395                 400 


Pro Leu Ser Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Pro Leu 
                405                 410                 415     


Ile Lys Arg Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr 
            420                 425                 430         


Thr Tyr Ser Asp Asn Gln Ser Ser Val Leu Val Gln Val Tyr Glu Gly 
        435                 440                 445             


Glu Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Asp Leu 
    450                 455                 460                 


Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr 
465                 470                 475                 480 


Phe Asp Ile Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Ala Asp Lys 
                485                 490                 495     


Ser Thr Gly Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg 
            500                 505                 510         


Leu Ser Lys Asp Asp Ile Asp Arg Met Val Gln Glu Ala Glu Arg Tyr 
        515                 520                 525             


Lys Ser Glu Asp Glu Ala Asn Arg Asp Arg Val Ala Ala Lys Asn Ala 
    530                 535                 540                 


Leu Glu Ser Tyr Thr Tyr Asn Ile Lys Gln Thr Val Glu Asp Glu Lys 
545                 550                 555                 560 


Leu Arg Gly Lys Ile Ser Glu Gln Asp Lys Asn Lys Ile Leu Asp Lys 
                565                 570                 575     


Cys Gln Glu Val Ile Asn Trp Leu Asp Arg Asn Gln Met Ala Glu Lys 
            580                 585                 590         


Asp Glu Tyr Glu His Lys Gln Lys Glu Leu Glu Arg Val Cys Asn Pro 
        595                 600                 605             


Ile Ile Ser Lys Leu Tyr Gln Gly Gly Pro Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Ala Ser Gly Gly Pro Thr Ile Glu Glu Val Asp 
625                 630                 635                 


<210>  50
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  50

Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg 
1               5                   10      


<210>  51
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  51

Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu Arg 
1               5                   10              


<210>  52
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  52

Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg 
1               5                   10                  15      


<210>  53
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  53

Phe Glu Glu Leu Cys Asp Ser Leu Phe Arg 
1               5                   10  


<210>  54
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  54

Leu Leu Gln Asp Phe Phe Asn Gly Arg 
1               5                   


<210>  55
<211>  840
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ser Val Val Gly Ile Asp Leu Gly Phe Gln Ser Cys Tyr Val Ala 
1               5                   10                  15      


Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Tyr Ser Asp 
            20                  25                  30          


Arg Cys Thr Pro Ala Cys Ile Ser Phe Gly Pro Lys Asn Arg Ser Ile 
        35                  40                  45              


Gly Ala Ala Ala Lys Ser Gln Val Ile Ser Asn Ala Lys Asn Thr Val 
    50                  55                  60                  


Gln Gly Phe Lys Arg Phe His Gly Arg Ala Phe Ser Asp Pro Phe Val 
65                  70                  75                  80  


Glu Ala Glu Lys Ser Asn Leu Ala Tyr Asp Ile Val Gln Leu Pro Thr 
                85                  90                  95      


Gly Leu Thr Gly Ile Lys Val Thr Tyr Met Glu Glu Glu Arg Asn Phe 
            100                 105                 110         


Thr Thr Glu Gln Val Thr Ala Met Leu Leu Ser Lys Leu Lys Glu Thr 
        115                 120                 125             


Ala Glu Ser Val Leu Lys Lys Pro Val Val Asp Cys Val Val Ser Val 
    130                 135                 140                 


Pro Cys Phe Tyr Thr Asp Ala Glu Arg Arg Ser Val Met Asp Ala Thr 
145                 150                 155                 160 


Gln Ile Ala Gly Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala 
                165                 170                 175     


Val Ala Leu Ala Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ala Leu Glu 
            180                 185                 190         


Glu Lys Pro Arg Asn Val Val Phe Val Asp Met Gly His Ser Ala Tyr 
        195                 200                 205             


Gln Val Ser Val Cys Ala Phe Asn Arg Gly Lys Leu Lys Val Leu Ala 
    210                 215                 220                 


Thr Ala Phe Asp Thr Thr Leu Gly Gly Arg Lys Phe Asp Glu Val Leu 
225                 230                 235                 240 


Val Asn His Phe Cys Glu Glu Phe Gly Lys Lys Tyr Lys Leu Asp Ile 
                245                 250                 255     


Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Ser Gln Glu Cys Glu Lys 
            260                 265                 270         


Leu Lys Lys Leu Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Ser Ile 
        275                 280                 285             


Glu Cys Phe Met Asn Asp Val Asp Val Ser Gly Thr Met Asn Arg Gly 
    290                 295                 300                 


Lys Phe Leu Glu Met Cys Asn Asp Leu Leu Ala Arg Val Glu Pro Pro 
305                 310                 315                 320 


Leu Arg Ser Val Leu Glu Gln Thr Lys Leu Lys Lys Glu Asp Ile Tyr 
                325                 330                 335     


Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
            340                 345                 350         


Lys Ile Ser Lys Phe Phe Gly Lys Glu Leu Ser Thr Thr Leu Asn Ala 
        355                 360                 365             


Asp Glu Ala Val Thr Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
    370                 375                 380                 


Pro Ala Phe Lys Val Arg Glu Phe Ser Ile Thr Asp Val Val Pro Tyr 
385                 390                 395                 400 


Pro Ile Ser Leu Arg Trp Asn Ser Pro Ala Glu Glu Gly Ser Ser Asp 
                405                 410                 415     


Cys Glu Val Phe Ser Lys Asn His Ala Ala Pro Phe Ser Lys Val Leu 
            420                 425                 430         


Thr Phe Tyr Arg Lys Glu Pro Phe Thr Leu Glu Ala Tyr Tyr Ser Ser 
        435                 440                 445             


Pro Gln Asp Leu Pro Tyr Pro Asp Pro Ala Ile Ala Gln Phe Ser Val 
    450                 455                 460                 


Gln Lys Val Thr Pro Gln Ser Asp Gly Ser Ser Ser Lys Val Lys Val 
465                 470                 475                 480 


Lys Val Arg Val Asn Val His Gly Ile Phe Ser Val Ser Ser Ala Ser 
                485                 490                 495     


Leu Val Glu Val His Lys Ser Glu Glu Asn Glu Glu Pro Met Glu Thr 
            500                 505                 510         


Asp Gln Asn Ala Lys Glu Glu Glu Lys Met Gln Val Asp Gln Glu Glu 
        515                 520                 525             


Pro His Val Glu Glu Gln Gln Gln Gln Thr Pro Ala Glu Asn Lys Ala 
    530                 535                 540                 


Glu Ser Glu Glu Met Glu Thr Ser Gln Ala Gly Ser Lys Asp Lys Lys 
545                 550                 555                 560 


Met Asp Gln Pro Pro Gln Ala Lys Lys Ala Lys Val Lys Thr Ser Thr 
                565                 570                 575     


Val Asp Leu Pro Ile Glu Asn Gln Leu Leu Trp Gln Ile Asp Arg Glu 
            580                 585                 590         


Met Leu Asn Leu Tyr Ile Glu Asn Glu Gly Lys Met Ile Met Gln Asp 
        595                 600                 605             


Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu Glu Tyr 
    610                 615                 620                 


Val Tyr Glu Met Arg Asp Lys Leu Ser Gly Glu Tyr Glu Lys Phe Val 
625                 630                 635                 640 


Ser Glu Asp Asp Arg Asn Ser Phe Thr Leu Lys Leu Glu Asp Thr Glu 
                645                 650                 655     


Asn Trp Leu Tyr Glu Asp Gly Glu Asp Gln Pro Lys Gln Val Tyr Val 
            660                 665                 670         


Asp Lys Leu Ala Glu Leu Lys Asn Leu Gly Gln Pro Ile Lys Ile Arg 
        675                 680                 685             


Phe Gln Glu Ser Glu Glu Arg Pro Lys Leu Phe Glu Glu Leu Gly Lys 
    690                 695                 700                 


Gln Ile Gln Gln Tyr Met Lys Ile Ile Ser Ser Phe Lys Asn Lys Glu 
705                 710                 715                 720 


Asp Gln Tyr Asp His Leu Asp Ala Ala Asp Met Thr Lys Val Glu Lys 
                725                 730                 735     


Ser Thr Asn Glu Ala Met Glu Trp Met Asn Asn Lys Leu Asn Leu Gln 
            740                 745                 750         


Asn Lys Gln Ser Leu Thr Met Asp Pro Val Val Lys Ser Lys Glu Ile 
        755                 760                 765             


Glu Ala Lys Ile Lys Glu Leu Thr Ser Thr Cys Ser Pro Ile Ile Ser 
    770                 775                 780                 


Lys Pro Lys Pro Lys Val Glu Pro Pro Lys Glu Glu Gln Lys Asn Ala 
785                 790                 795                 800 


Glu Gln Asn Gly Pro Val Asp Gly Gln Gly Asp Asn Pro Gly Pro Gln 
                805                 810                 815     


Ala Ala Glu Gln Gly Thr Asp Thr Ala Val Pro Ser Asp Ser Asp Lys 
            820                 825                 830         


Lys Leu Pro Glu Met Asp Ile Asp 
        835                 840 


<210>  56
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  56

Glu Leu Ser Thr Thr Leu Asn Ala Asp Glu Ala Val Thr Arg 
1               5                   10                  


<210>  57
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 
            20                  25                  30          


Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 
        35                  40                  45              


Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser 
    50                  55                  60                  


Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 
65                  70                  75                  80  


Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 
                85                  90                  95      


Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 
            100                 105                 110         


Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 
        115                 120                 125             


Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 
    130                 135                 140                 


Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 
145                 150                 155                 160 


Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 
                165                 170                 175     


Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 
            180                 185                 190         


Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 
        195                 200                 205             


Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 
    210                 215                 220                 


Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 
225                 230                 235                 240 


Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 
                245                 250                 255     


Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 
            260                 265                 270         


Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 
        275                 280                 285             


Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 
    290                 295                 300                 


Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 
305                 310                 315                 320 


Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 
                325                 330                 335     


Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 
            340                 345                 350         


Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 
        355                 360                 365             


Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 
    370                 375                 380                 


Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu 
                405                 410                 415     


Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 
            420                 425                 430         


Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 
        435                 440                 445             


Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 
    450                 455                 460                 


Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 
465                 470                 475                 480 


Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
                485                 490                 495     


Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 
            500                 505                 510         


Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 
        515                 520                 525             


Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 
    530                 535                 540                 


Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 
545                 550                 555                 560 


Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 
                565                 570                 575     


Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 
            580                 585                 590         


Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 
        595                 600                 605             


Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 
    610                 615                 620                 


Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 
625                 630                 635                 640 


Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
                645                 650                 


<210>  58
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  58

Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg 
1               5                   10      


<210>  59
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  59

Ile Thr Pro Ser Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg 
1               5                   10                  


<210>  60
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  60

Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys 
1               5                   10                  15      


<210>  61
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  61

Ser Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile 
1               5                   10                  15      


Lys 
    


<210>  62
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gln Ala Pro Arg Glu Leu Ala Val Gly Ile Asp Leu Gly Thr Thr 
1               5                   10                  15      


Tyr Ser Cys Val Gly Val Phe Gln Gln Gly Arg Val Glu Ile Leu Ala 
            20                  25                  30          


Asn Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp 
        35                  40                  45              


Thr Glu Arg Leu Val Gly Asp Ala Ala Lys Ser Gln Ala Ala Leu Asn 
    50                  55                  60                  


Pro His Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe 
65                  70                  75                  80  


Ala Asp Thr Thr Val Gln Ser Asp Met Lys His Trp Pro Phe Arg Val 
                85                  90                  95      


Val Ser Glu Gly Gly Lys Pro Lys Val Arg Val Cys Tyr Arg Gly Glu 
            100                 105                 110         


Asp Lys Thr Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Ser Lys 
        115                 120                 125             


Met Lys Glu Thr Ala Glu Ala Tyr Leu Gly Gln Pro Val Lys His Ala 
    130                 135                 140                 


Val Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr 
145                 150                 155                 160 


Lys Asp Ala Gly Ala Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn 
                165                 170                 175     


Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Arg Gly Ala 
            180                 185                 190         


Gly Glu Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp 
        195                 200                 205             


Val Ser Val Leu Ser Ile Asp Ala Gly Val Phe Glu Val Lys Ala Thr 
    210                 215                 220                 


Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val 
225                 230                 235                 240 


Asn His Phe Met Glu Glu Phe Arg Arg Lys His Gly Lys Asp Leu Ser 
                245                 250                 255     


Gly Asn Lys Arg Ala Leu Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala 
            260                 265                 270         


Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Thr Leu Glu Ile Asp Ser 
        275                 280                 285             


Leu Phe Glu Gly Val Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe 
    290                 295                 300                 


Glu Glu Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu 
305                 310                 315                 320 


Lys Ala Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Val 
                325                 330                 335     


Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu 
            340                 345                 350         


Gln Asp Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp 
        355                 360                 365             


Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Val Leu Met Gly 
    370                 375                 380                 


Asp Lys Cys Glu Lys Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro 
385                 390                 395                 400 


Leu Ser Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Thr Leu Ile 
                405                 410                 415     


Gln Arg Asn Ala Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr 
            420                 425                 430         


Tyr Ser Asp Asn Gln Pro Gly Val Phe Ile Gln Val Tyr Glu Gly Glu 
        435                 440                 445             


Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser 
    450                 455                 460                 


Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe 
465                 470                 475                 480 


Asp Ile Asp Ala Asn Gly Ile Leu Ser Val Thr Ala Thr Asp Arg Ser 
                485                 490                 495     


Thr Gly Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu 
            500                 505                 510         


Ser Lys Glu Glu Val Glu Arg Met Val His Glu Ala Glu Gln Tyr Lys 
        515                 520                 525             


Ala Glu Asp Glu Ala Gln Arg Asp Arg Val Ala Ala Lys Asn Ser Leu 
    530                 535                 540                 


Glu Ala His Val Phe His Val Lys Gly Ser Leu Gln Glu Glu Ser Leu 
545                 550                 555                 560 


Arg Asp Lys Ile Pro Glu Glu Asp Arg Arg Lys Met Gln Asp Lys Cys 
                565                 570                 575     


Arg Glu Val Leu Ala Trp Leu Glu His Asn Gln Leu Ala Glu Lys Glu 
            580                 585                 590         


Glu Tyr Glu His Gln Lys Arg Glu Leu Glu Gln Ile Cys Arg Pro Ile 
        595                 600                 605             


Phe Ser Arg Leu Tyr Gly Gly Pro Gly Val Pro Gly Gly Ser Ser Cys 
    610                 615                 620                 


Gly Thr Gln Ala Arg Gln Gly Asp Pro Ser Thr Gly Pro Ile Ile Glu 
625                 630                 635                 640 


Glu Val Asp 
            


<210>  63
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  63

Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu Arg 
1               5                   10              


<210>  64
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  64

Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg 
1               5                   10                  15      


<210>  65
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  65

Phe Glu Glu Leu Cys Ser Asp Leu Phe Arg 
1               5                   10  


<210>  66
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  66

Leu Leu Gln Asp Phe Phe Asn Gly Lys 
1               5                   


<210>  67
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  68
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  68

Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg 
1               5                   10      


<210>  69
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  69

Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu Arg 
1               5                   10              


<210>  70
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  70

Thr Val Thr Asn Ala Val Val Thr Asn Pro Ala Tyr Phe Asn Asp Ser 
1               5                   10                  15      


Gln Arg 
        


<210>  71
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  71

Asp Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg 
1               5                   10          


<210>  72
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  72

Ile Ile Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys 
1               5                   10                  15  


<210>  73
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  73

Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
1               5                   10                  15      


Glu Phe Ile Asp Phe Tyr Thr Ser Ile Thr Arg 
            20                  25          


<210>  74
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  74

Phe Glu Glu Leu Asn Ala Asp Leu Phe Arg 
1               5                   10  


<210>  75
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  75

Ser Gln Ile His Asp Ile Val Leu Val Gly Gly Ser Thr Arg 
1               5                   10                  


<210>  76
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210>  77
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  77

Glu Gln Gln Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys 
1               5                   10                  


<210>  78
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp 
        115                 120                 125             


Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala 
    130                 135                 140                 


Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe 
145                 150                 155                 160 


Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala 
                165                 170                 175     


Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 
            180                 185                 190         


Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys 
        195                 200                 205             


Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 
    210                 215                 220                 


Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe 
225                 230                 235                 240 


Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His 
                245                 250                 255     


Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 
            260                 265                 270         


Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe 
        275                 280                 285             


Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 
    290                 295                 300                 


Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu 
305                 310                 315                 320 


Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala 
                325                 330                 335     


Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 
            340                 345                 350         


Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro 
        355                 360                 365             


Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 
    370                 375                 380                 


Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 
385                 390                 395                 400 


Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp 
                405                 410                 415     


His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 
            420                 425                 430         


Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala 
        435                 440                 445             


Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 
    450                 455                 460                 


Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp 
465                 470                 475                 480 


Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu 
                485                 490                 495     


Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 
            500                 505             


<210>  79
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  79

Ser Asn Phe Ala Glu Ala Leu Ala Ala His Lys 
1               5                   10      


<210>  80
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  80

Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala Ala Ala Glu Ser 
1               5                   10                  15      


Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe Phe Lys 
            20                  25                  30  


<210>  81
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  81

Gln Phe Leu Gln Ala Ala Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile 
1               5                   10                  15      


Thr Ser Asn Ser Asp Val Phe Ser Lys 
            20                  25  


<210>  82
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  82

His Asn Gln Leu Pro Leu Val Ile Glu Phe Thr Glu Gln Thr Ala Pro 
1               5                   10                  15      


Lys 
    


<210>  83
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  83

Thr His Ile Leu Leu Phe Leu Pro Lys 
1               5                   


<210>  84
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg 
385                 390                 395                 400 


Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala 
                405                 410                 415     


Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr 
            420                 425                 430         


Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  85
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  85

Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg 
1               5                   10      


<210>  86
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  86

Asn Thr Gly Ile Ile Cys Thr Ile Gly Pro Ala Ser Arg 
1               5                   10              


<210>  87
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  87

Thr Ala Thr Glu Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val 
1               5                   10                  15      


Ala Val Ala Leu Asp Thr Lys 
            20              


<210>  88
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  88

Ile Tyr Val Asp Asp Gly Leu Ile Ser Leu Gln Val Lys 
1               5                   10              


<210>  89
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  89

Gly Ala Asp Phe Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly 
1               5                   10                  15      


Ser Lys 
        


<210>  90
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  90

Lys Gly Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser 
1               5                   10                  15      


Glu Lys 
        


<210>  91
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  91

Gly Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu 
1               5                   10                  15      


Lys 
    


<210>  92
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  92

Phe Gly Val Glu Gln Asp Val Asp Met Val Phe Ala Ser Phe Ile Arg 
1               5                   10                  15      


<210>  93
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  93

Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu Lys 
1               5                   10      


<210>  94
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  94

Ala Glu Gly Ser Asp Val Ala Asn Ala Val Leu Asp Gly Ala Asp Cys 
1               5                   10                  15      


Ile Met Leu Ser Gly Glu Thr Ala Lys 
            20                  25  


<210>  95
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  95

Glu Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg 
1               5                   10                  15      


<210>  96
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  96

Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala 
1               5                   10                  15      


Val Glu Ala Ser Phe Lys 
            20          


<210>  97
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  97

Cys Cys Ser Gly Ala Ile Ile Val Leu Thr Lys 
1               5                   10      


<210>  98
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  98

Gly Ile Phe Pro Val Leu Cys Lys 
1               5               


<210>  99
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  99

Asp Pro Val Gln Glu Ala Trp Ala Glu Asp Val Asp Leu Arg 
1               5                   10                  


<210>  100
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  101
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  101

Gly Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys 
1               5                   10              


<210>  102
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  102

Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
1               5                   10                  15      


Leu Arg 
        


<210>  103
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  103

Phe Gly Ala Asn Ala Ile Leu Gly Val Ser Leu Ala Val Cys Lys 
1               5                   10                  15  


<210>  104
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  104

His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile Leu Pro Val Pro 
1               5                   10                  15      


Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly Asn Lys 
            20                  25                  30  


<210>  105
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  105

Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala Asn Phe 
1               5                   10                  15      


Arg 
    


<210>  106
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  106

Asp Ala Thr Asn Val Gly Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu 
1               5                   10                  15      


Glu Asn Lys 
            


<210>  107
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  107

Val Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg 
1               5                   10                  


<210>  108
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  108

Tyr Ile Ser Pro Asp Gln Leu Ala Asp Leu Tyr Lys 
1               5                   10          


<210>  109
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  109

Asp Tyr Pro Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp 
1               5                   10                  15      


Gly Ala Trp Gln Lys 
            20      


<210>  110
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  110

Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu Thr Val 
1               5                   10                  15      


Thr Asn Pro Lys 
            20  


<210>  111
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  111

Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val Val Gly Leu 
1               5                   10                  15      


Cys Thr Gly Gln Ile Lys 
            20          


<210>  112
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210>  113
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  113

Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp Ser Leu Leu Ala Gly 
1               5                   10                  15      


Pro Val Ala Glu Tyr Leu Lys 
            20              


<210>  114
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  114

Val Glu Asn Gln Glu Asn Val Ser Asn Leu Val Ile Glu Asp Thr Glu 
1               5                   10                  15      


Leu Lys 
        


