                         SEQUENCE LISTING

<110>  Novavax, Inc.
 
<120>  Bovine Respiratory Syncytial Virus Virus-Like Particles (VLPs)

<130>  NOVV-037/01WO

<150>  US 61/121,126
<151>  2008-12-09

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  256
<212>  PRT
<213>  Bovine respiratory syncytial virus

<400>  1

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Ile Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Ile Ser Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ile Asn Val Asn Ile Leu Val Arg Gln Ile Ser Thr 
    50                  55                  60                  


Leu Lys Gly Pro Ser Leu Lys Ile Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Ser Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Ile Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Val Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Phe Asn Pro Thr His Glu Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Met Thr Ser Lys Arg Val Val Ile 
145                 150                 155                 160 


Pro Thr Phe Leu Arg Ser Ile Asn Val Lys Ala Lys Asp Leu Asp Ser 
                165                 170                 175     


Leu Glu Asn Ile Ala Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ala Gly Leu Val Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Lys Phe Ser Ile Lys Pro Ile Glu Asp 
                245                 250                 255     


<210>  2
<211>  574
<212>  PRT
<213>  Human respiratory syncytial virus

<400>  2

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Pro Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Ile Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Met Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 


<210>  3
<211>  298
<212>  PRT
<213>  respiratory syncytial virus

<400>  3

Met Ser Lys Asn Lys Asp Gln Arg Thr Ala Lys Thr Leu Glu Arg Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn His Leu Leu Phe Ile Ser Ser Cys Leu Tyr Lys 
            20                  25                  30          


Leu Asn Leu Lys Ser Val Ala Gln Ile Thr Leu Ser Ile Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Ala Ala Ile Ile Phe Ile Ala Ser 
    50                  55                  60                  


Ala Asn His Lys Val Thr Pro Thr Thr Ala Ile Ile Gln Asp Ala Thr 
65                  70                  75                  80  


Ser Gln Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asn Pro Gln 
                85                  90                  95      


Leu Gly Ile Ser Pro Ser Asn Pro Ser Glu Ile Thr Ser Gln Ile Thr 
            100                 105                 110         


Thr Ile Leu Ala Ser Thr Thr Pro Gly Val Lys Ser Thr Leu Gln Ser 
        115                 120                 125             


Thr Thr Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Thr Gln Pro Ser 
    130                 135                 140                 


Lys Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Ser Lys Pro Asn 
145                 150                 155                 160 


Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys 
            180                 185                 190         


Lys Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Leu 
        195                 200                 205             


Lys Thr Thr Lys Lys Asp Pro Lys Pro Gln Thr Thr Lys Ser Lys Glu 
    210                 215                 220                 


Val Pro Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys 
225                 230                 235                 240 


Thr Asn Ile Ile Thr Thr Leu Leu Thr Ser Asn Thr Thr Gly Asn Pro 
                245                 250                 255     


Glu Leu Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly 
            260                 265                 270         


Asn Pro Ser Pro Ser Gln Val Ser Thr Thr Ser Glu Tyr Pro Ser Gln 
        275                 280                 285             


Pro Ser Ser Pro Pro Asn Thr Pro Arg Gln 
    290                 295             


<210>  4
<211>  391
<212>  PRT
<213>  respiratory syncytial virus

<400>  4

Met Ala Leu Ser Lys Val Lys Leu Asn Asp Thr Leu Asn Lys Asp Gln 
1               5                   10                  15      


Leu Leu Ser Ser Ser Lys Tyr Thr Ile Gln Arg Ser Thr Gly Asp Ser 
            20                  25                  30          


Ile Asp Thr Pro Asn Tyr Asp Val Gln Lys His Ile Asn Lys Leu Cys 
        35                  40                  45              


Gly Met Leu Leu Ile Thr Glu Asp Ala Asn His Lys Phe Thr Gly Leu 
    50                  55                  60                  


Ile Gly Met Leu Tyr Ala Met Ser Arg Leu Gly Arg Glu Asp Thr Ile 
65                  70                  75                  80  


Lys Ile Leu Arg Asp Ala Gly Tyr His Val Lys Ala Asn Gly Val Asp 
                85                  90                  95      


Val Thr Thr His Arg Gln Asp Ile Asn Gly Lys Glu Met Lys Phe Glu 
            100                 105                 110         


Val Leu Thr Leu Ala Ser Leu Thr Thr Glu Ile Gln Ile Asn Ile Glu 
        115                 120                 125             


Ile Glu Ser Arg Lys Ser Tyr Lys Lys Met Leu Lys Glu Met Gly Glu 
    130                 135                 140                 


Val Ala Pro Glu Tyr Arg His Asp Ser Pro Asp Cys Gly Met Ile Ile 
145                 150                 155                 160 


Leu Cys Ile Ala Ala Leu Val Ile Thr Lys Leu Ala Ala Gly Asp Arg 
                165                 170                 175     


Ser Gly Leu Thr Ala Val Ile Arg Arg Ala Asn Asn Val Leu Lys Asn 
            180                 185                 190         


Glu Met Lys Arg Tyr Lys Gly Leu Leu Pro Lys Asp Ile Ala Asn Ser 
        195                 200                 205             


Phe Tyr Glu Val Phe Glu Lys His Pro His Phe Ile Asp Val Phe Val 
    210                 215                 220                 


His Phe Gly Ile Ala Gln Ser Ser Thr Arg Gly Gly Ser Arg Val Glu 
225                 230                 235                 240 


Gly Ile Phe Ala Gly Leu Phe Met Asn Ala Tyr Gly Ala Gly Gln Val 
                245                 250                 255     


Met Leu Arg Trp Gly Val Leu Ala Lys Ser Val Lys Asn Ile Met Leu 
            260                 265                 270         


Gly His Ala Ser Val Gln Ala Glu Met Glu Gln Val Val Glu Val Tyr 
        275                 280                 285             


Glu Tyr Ala Gln Lys Leu Gly Gly Glu Ala Gly Phe Tyr His Ile Leu 
    290                 295                 300                 


Asn Asn Pro Lys Ala Ser Leu Leu Ser Leu Thr Gln Phe Pro His Phe 
305                 310                 315                 320 


Ser Ser Val Val Leu Gly Asn Ala Ala Gly Leu Gly Ile Met Gly Glu 
                325                 330                 335     


Tyr Arg Gly Thr Pro Arg Asn Gln Asp Leu Tyr Asp Ala Ala Lys Ala 
            340                 345                 350         


Tyr Ala Glu Gln Leu Lys Glu Asn Gly Val Ile Asn Tyr Ser Val Leu 
        355                 360                 365             


Asp Leu Thr Ala Glu Glu Leu Glu Ala Ile Lys His Gln Leu Asn Pro 
    370                 375                 380                 


Lys Asp Asn Asp Val Glu Leu 
385                 390     


<210>  5
<211>  256
<212>  PRT
<213>  respiratory syncytial virus

<400>  5

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  6
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRSV F chimeric with BRSV F0 cytoplasmic domain replacement

<400>  6

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Phe Tyr Cys Lys Thr Lys Ser Thr Pro Ile Met Leu Gly 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Leu Ser Phe Ser Lys 
                565                 570                 


<210>  7
<211>  771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized Bovine RSV M

<400>  7
atggagactt acgtgaacaa gctgcacgag ggttccacct acaccgctgc tgtgcagtac       60

aacgtgatcg agaaggacga cgaccccgct tccctgacca tctgggtgcc catgttccag      120

tcctccatct ccgctgacct gctgatcaag gagctgatca acgtcaacat cctcgtgcgt      180

cagatctcca ccctgaaggg tcccagcctg aagatcatga tcaactcccg ttccgctgtg      240

ctggctcaga tgccctccaa gttcaccatc tccgccaacg tgtccctgga cgagcgttcc      300

aagctggctt acgacatcac caccccctgc gagatcaagg cttgctccct gacctgcctg      360

aaggtcaaga acatgctgac caccgtgaag gacctgacca tgaagacctt caaccccacc      420

cacgagatca tcgctctgtg cgagttcgag aacatcatga cctccaagcg tgtggtcatc      480

cccaccttcc tccgctccat caacgtgaag gctaaggacc tggactccct cgagaacatc      540

gctaccaccg agttcaagaa cgctatcacc aacgctaaga tcatccctta cgctggcctg      600

gtgctggtca tcaccgtgac cgacaacaag ggcgctttca agtacatcaa gccccagtcc      660

cagttcatcg tggacctggg cgcttacctc gagaaggagt ccatctacta cgtcaccacc      720

aactggaagc acaccgctac caagttctcc atcaagccca tcgaggacta a               771


<210>  8
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized HRSV-A F

<400>  8
atggagctgc tcatcttgaa ggctaacgcc attaccacta tccttacagc ggtgacgttc       60

tgctttgcat ccggtcagaa tattaccgaa gagttctacc aatctacttg tagcgctgtc      120

tcaaaaggct atctgtcggc cctccgtaca ggatggtaca cgagtgttat caccatcgaa      180

ttgtccaaca ttaaggagaa taaatgcaac ggtactgacg cgaaggtaaa gcttatcaaa      240

caggaactgg ataagtacaa gaacgcagtg acagagctcc aattgctgat gcagtctacc      300

ccccctacga ataaccgcgc taggagagaa cttccacgat tcatgaacta tactctcaat      360

aacgccaaaa agaccaacgt cacattgagc aaaaagcgta agcgcaggtt tctgggcttc      420

ctcctgggag ttggttcagc tattgcgtcg ggcgtagccg tgagtaaagt ccttcacttg      480

gagggagaag ttaataagat caagtccgca ctcctgtcta ctaacaaagc tgtggtcagc      540

ttgtcaaacg gtgtatccgt gctgacctcg aaggttcttg acctcaaaaa ttacatcgat      600

aagcaattgc tgccgattgt caacaagcag agttgttcta tcagcaatat tgagacggtg      660

atcgagttcc aacagaaaaa caacagactc ctggaaatca cacgtgagtt ttcagtaaat      720

gccggcgtta ctacccccgt ctccacgtac atgcttacaa actcggaatt gctcagtctg      780

attaacgaca tgcctatcac taatgatcag aagaagctta tgtctaacaa cgtgcaaatt      840

gtccgccagc aaagctattc catcatgtca atcattaaag aggaagtgtt ggcgtacgta      900

gttcagctcc cactgtacgg agtcatcgac accccgtgct ggaagcttca tacctcgccc      960

ttgtgtacga caaatactaa agagggttct aacatttgcc tcaccaggac ggatcgaggc     1020

tggtattgcg ataacgctgg aagtgtgagc ttcttccctc aagcagaaac atgtaaggta     1080

cagtccaata gagttttttg cgacactatg aactcactga cccttccatc tgagatcaat     1140

ttgtgtaacg tcgatatctt caacccgaag tacgactgca aaattatgac gtccaagaca     1200

gatgtgtcga gtagcgtaat cacttcactc ggtgccatcg tttcttgcta cggcaagacc     1260

aaatgtacgg cttccaataa gaaccgtgga attatcaaaa cattctcgaa cggttgcgac     1320

tatgtcagca ataagggcat ggacactgtg agtgtaggaa acaccctgta ctacgttaac     1380

aagcaagaag gtaaatcact gtatgtcaag ggcgagccca ttatcaattt ttacgatcct     1440

cttgtgttcc catccgacga gttcgatgcg tctatcagcc aggtaaacga aaagattaac     1500

cagtccttgg catttatccg caaatcggac gagctcctgc acaatgttaa cgccggaaag     1560

agtacgacaa acattatgat cactaccatc attatcgtca ttatcgtgat ccttttgtca     1620

ctcattgctg taggtctgct tttgtactgt aaagcgaggt ctacgcccgt tacactcagc     1680

aaggatcaac tgtccggcat caataacatt gccttctcga attaa                     1725


<210>  9
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized RSV G

<400>  9
atgtccaaga acaaagacca gcgtaccgct aagactctgg agcgcacatg ggatacgctc       60

aatcacttgc ttttcatctc tagctgcctg tacaaactca acttgaagtc agtggcccaa      120

attacccttt cgatcctggc gatgattatc agtacttccc tcatcattgc agctatcatt      180

tttatcgcct ctgcgaatca taaggtcaca cccacgaccg caatcattca ggacgctact      240

agccaaatca aaaacacaac ccctacgtat ttgactcaga acccacaact gggtatttca      300

ccgtcgaatc ccagtgaaat cacctcccag atcacaacta ttcttgcctc taccacgcct      360

ggcgttaaga gcacactcca atcaactacc gtaaagacga aaaacacaac taccacccag      420

acgcagccat ccaagccgac aactaaacaa aggcagaaca agcccccttc gaagccaaat      480

aacgatttcc acttcgaggt gtttaacttc gtcccgtgta gtatctgctc taataacccc      540

acctgttggg ctatttgcaa aagaatccct aacaagaagc caggaaaaaa gacgacaact      600

aaacccacca agaagcctac gttgaaaaca actaagaagg acccgaaacc acaaaccacg      660

aagagcaaag aagttcccac aactaagcct accgaggaac cgacgatcaa tacaactaag      720

accaacatta tcacgacact gctcacttca aataccactg gtaacccaga gctgacctcc      780

cagatggaaa ccttccattc gacgagttct gagggcaacc ccagcccttc ccaagtatca      840

acaacttcgg aatacccatc tcagcccagt agccctccga ataccccacg acaataa         897


<210>  10
<211>  1203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized RSV N

<400>  10
ggtaccggat ccgccaccat ggctctgtcc aaggtcaagc tgaacgacac cctgaacaag       60

gaccagctgc tgtcctcctc caagtacacc atccagcgtt ccaccggtga ctccatcgac      120

acccccaact acgacgtgca gaagcacatc aacaagctgt gcggcatgct gctgatcacc      180

gaggacgcta accacaagtt caccggtctg atcggcatgc tgtacgctat gtcccgtctg      240

ggtcgtgagg acaccatcaa gatcctgcgt gacgctggtt accacgtgaa ggctaacggt      300

gtcgacgtga ccacccaccg tcaggacatc aacggcaagg agatgaagtt cgaggtcctg      360

accctggctt ccctgaccac cgagatccag atcaacatcg agatcgagtc ccgtaagtcc      420

tacaagaaga tgctgaagga gatgggcgag gtcgcccccg agtaccgtca cgactccccc      480

gactgcggca tgatcatcct gtgcatcgct gctctcgtca tcaccaagct ggctgctggt      540

gaccgttccg gtctgaccgc tgtgatccgt cgtgctaaca acgtgctgaa gaacgagatg      600

aagcgctaca agggtctgct gcccaaggac atcgctaaca gcttctacga ggtgttcgag      660

aagcaccccc acttcatcga cgtgttcgtg cacttcggta tcgctcagtc ctccacccgt      720

ggtggttccc gtgtggaggg catcttcgct ggtctgttca tgaacgctta cggtgctggc      780

caggtcatgc tgcgttgggg tgtgctggct aagtccgtga agaacatcat gctgggtcac      840

gcttccgtgc aggctgagat ggagcaggtg gtggaggtgt acgagtacgc tcagaagctg      900

ggcggcgagg ctggtttcta ccacatcctg aacaacccca aggcttccct gctgtccctg      960

acccagttcc cccacttctc ctccgtggtg ctgggtaacg ctgctggtct gggtatcatg     1020

ggcgagtacc gtggcacccc ccgtaaccag gacctgtacg acgctgctaa ggcttacgcc     1080

gagcagctca aggagaacgg cgtcatcaac tactccgtgc tggacctgac cgctgaggag     1140

ctggaggcta tcaagcacca gctgaacccc aaggacaacg acgtggagct gtaataaaag     1200

ctt                                                                   1203


<210>  11
<211>  771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized RSV M

<400>  11
atggagacct acgtgaacaa gctgcacgaa ggttccactt atacagctgc cgtccagtac       60

aatgttctcg agaaagacga tgaccccgcg tctttgacga tctgggttcc tatgttccaa      120

agctcaatgc cagcagatct tctgattaag gaactcgcta acgtgaatat cttggtcaaa      180

cagatttcga ccccgaaggg cccctcgctt cgtgttatga tcaactcccg ctctgccgta      240

ctggcgcaaa tgcctagcaa gtttactatc tgcgcaaacg tgtcactcga cgagaggtcg      300

aaattggctt acgatgtcac aacgccatgt gaaattaagg cctgcagtct gacctgtctt      360

aagtccaaaa atatgctcac tacagttaag gacttgacca tgaaaacgct gaacccgact      420

catgacatca ttgctctctg cgagttcgaa aacatcgtga cctctaagaa ggtcatcatt      480

cccacatatc tgagaagcat ctcagtacga aataaagatc ttaacacttt ggagaacatt      540

accacgacag aatttaagaa tgcgatcact aacgccaaga tcattcctta ctccggactc      600

ctgttggtga tcaccgttac ggacaacaaa ggtgcattta agtacattaa accacagtcg      660

caattcatcg tcgatctggg cgcttatctt gagaaggaga gtatctacta cgtgacaact      720

aattggaagc acaccgccac ccgtttcgcg attaaaccga tggaagatta a               771


<210>  12
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized hRSV F chimeric with BRSV F0 cytoplasmic domain 
       replacement

<400>  12
atggagctgc tcatcttgaa ggctaacgcc attaccacta tccttacagc ggtgacgttc       60

tgctttgcat ccggtcagaa tattaccgaa gagttctacc aatctacttg tagcgctgtc      120

tcaaaaggct atctgtcggc cctccgtaca ggatggtaca cgagtgttat caccatcgaa      180

ttgtccaaca ttaaggagaa caagtgcaac ggtactgacg cgaaggtaaa gcttatcaaa      240

caggaactgg ataagtacaa gaacgcagtg acagagctcc aattgctgat gcagtctacc      300

cccgctacga ataaccgcgc taggagagaa cttccacgat tcatgaacta tactctcaat      360

aacgccaaaa agaccaacgt cacattgagc aaaaagcgta agcgcaggtt tctgggcttc      420

ctcctgggag ttggttcagc tattgcgtcg ggcgtagccg tgagtaaagt ccttcacttg      480

gagggagaag ttaataagat caagtccgca ctcctgtcta ctaacaaagc tgtggtcagc      540

ttgtcaaacg gtgtatccgt gctgacctcg aaggttcttg acctcaaaaa ttacatcgat      600

aagcaattgc tgccgattgt caacaagcag agttgttcta tcagcaatat tgagacggtg      660

atcgagttcc aacagaaaaa caacagactc ctggaaatca cacgtgagtt ttcagtaaat      720

gccggcgtta ctacccccgt ctccacgtac atgcttacaa actcggaatt gctcagtctg      780

attaacgaca tgcctatcac taatgatcag aagaagctta tgtctaacaa cgtgcaaatt      840

gtccgccagc aaagctattc catcatgtca atcattaaag aggaagtgtt ggcgtacgta      900

gttcagctcc cactgtacgg agtcatcgac accccgtgct ggaagcttca tacctcgccc      960

ttgtgtacga caaatactaa agagggttct aacatttgcc tcaccaggac ggatcgaggc     1020

tggtattgcg ataacgctgg aagtgtgagc ttcttccctc aagcagaaac atgtaaggta     1080

cagtccaata gagttttttg cgacactatg aactcactga cccttccatc tgaggtcaat     1140

ttgtgtaacg tcgatatctt caacccgaag tacgactgca aaattatgac gtccaagaca     1200

gatgtgtcga gtagcgtaat cacttcactc ggtgccatcg tttcttgcta cggcaagacc     1260

aaatgtacgg cttccaataa gaaccgtgga attatcaaaa cattctcgaa cggttgcgac     1320

tatgtcagca ataagggcgt ggacactgtg agtgtaggaa acaccctgta ctacgttaac     1380

aagcaagaag gtaaatcact gtatgtcaag ggcgagccca ttatcaattt ttacgatcct     1440

cttgtgttcc catccgacga gttcgatgcg tctatcagcc aggtaaacga aaagattaac     1500

cagtccttgg catttatccg caaatcggac gagctcctgc acaatgttaa cgccggaaag     1560

agtacgacaa acattatgat cactaccatc attatcgtca ttatcgtgat ccttttgtca     1620

ctcattgctg taggtctgct tttctactgt aaaacgaagt ctacgcccat tatgctcggg     1680

aaggatcaac tgtccggcat caataacctt tccttctcga agtaa                     1725


