                         SEQUENCE LISTING

<110>  Gautier, Jean
       Kopelovich, Levy
 
<120>  INHIBITORS OF MRE11, RAD50 AND/OR NBS1

<130>  NIH0045PCT

<150>  US61/203,377
<151>  2008-12-22

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide used as a negative control

<400>  1

Ala Val Gly Lys Lys Ala Ala Gln Ala Ala Gln Glu Tyr 
1               5                   10              


<210>  2
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide derived from histone H~AX peptide

<400>  2

Ala Val Gly Lys Lys Ala Ser Gln Ala Ser Gln Glu Tyr 
1               5                   10              


<210>  3
<211>  5164
<212>  DNA
<213>  Homo sapiens

<400>  3
acgttatcca tgaagtgtcg cgagagaaac ggacgccgtt ctctcccgcg gaattcaggt       60

ttacggccct gcgggttctc agaggcaagt tcagaccgtg ttgttttctt ttcacggatc      120

ctgccctttc ttcccgaaaa gaagacagcc ttgggtcgcg attgtggggc ttcgaagagt      180

ccagcagtgg gaatttctag aatttggaat cgagtgcatt ttctgacatt tgagtacagt      240

acccaggggt tcttggagaa gaacctggtc ccagaggagc ttgactgacc ataaaaatga      300

gtactgcaga tgcacttgat gatgaaaaca catttaaaat attagttgca acagatattc      360

atcttggatt tatggagaaa gatgcagtca gaggaaatga tacgtttgta acactcgatg      420

aaattttaag acttgcccag gaaaatgaag tggattttat tttgttaggt ggtgatcttt      480

ttcatgaaaa taagccctca aggaaaacat tacatacctg cctcgagtta ttaagaaaat      540

attgtatggg tgatcggcct gtccagtttg aaattctcag tgatcagtca gtcaactttg      600

gttttagtaa gtttccatgg gtgaactatc aagatggcaa cctcaacatt tcaattccag      660

tgtttagtat tcatggcaat catgacgatc ccacaggggc agatgcactt tgtgccttgg      720

acattttaag ttgtgctgga tttgtaaatc actttggacg ttcaatgtct gtggagaaga      780

tagacattag tccggttttg cttcaaaaag gaagcacaaa gattgcgcta tatggtttag      840

gatccattcc agatgaaagg ctctatcgaa tgtttgtcaa taaaaaagta acaatgttga      900

gaccaaagga agatgagaac tcttggttta acttatttgt gattcatcag aacaggagta      960

aacatggaag tactaacttc attccagaac aatttttgga tgacttcatt gatcttgtta     1020

tctggggcca tgaacatgag tgtaaaatag ctccaaccaa aaatgaacaa cagctgtttt     1080

atatctcaca acctggaagc tcagtggtta cttctctttc cccaggagaa gctgtaaaga     1140

aacatgttgg tttgctgcgt attaaaggga ggaagatgaa tatgcataaa attcctcttc     1200

acacagtgcg gcagtttttc atggaggata ttgttctagc taatcatcca gacattttta     1260

acccagataa tcctaaagta acccaagcca tacaaagctt ctgtttggag aagattgaag     1320

aaatgcttga aaatgctgaa cgggaacgtc tgggtaattc tcaccagcca gagaagcctc     1380

ttgtacgact gcgagtggac tatagtggag gttttgaacc tttcagtgtt cttcgcttta     1440

gccagaaatt tgtggatcgg gtagctaatc caaaagacat tatccatttt ttcaggcata     1500

gagaacaaaa ggaaaaaaca ggagaagaga tcaactttgg gaaacttatc acaaagcctt     1560

cagaaggaac aactttaagg gtagaagatc ttgtaaaaca gtactttcaa accgcagaga     1620

agaatgtgca gctctcactg ctaacagaaa gagggatggg tgaagcagta caagaatttg     1680

tggacaagga ggagaaagat gccattgagg aattagtgaa ataccagttg gaaaaaacac     1740

agcgatttct taaagaacgt catattgatg ccctcgaaga caaaatcgat gaggaggtac     1800

gtcgtttcag agaaaccaga caaaaaaata ctaatgaaga agatgatgaa gtccgtgagg     1860

ctatgaccag ggccagagca ctcagatctc agtcagagga gtctgcttct gcctttagtg     1920

ctgatgacct tatgagtata gatttagcag aacagatggc taatgactct gatgatagca     1980

tctcagcagc aaccaacaaa ggaagaggcc gaggaagagg tcgaagaggt ggaagagggc     2040

agaattcagc atcgagagga gggtctcaaa gaggaagagc ctttaaatct acaagacagc     2100

agccttcccg aaatgtcact actaagaatt attcagaggt gattgaggta gatgaatcag     2160

atgtggaaga agacattttt cctaccactt caaagacaga tcaaaggtgg tccagcacat     2220

catccagcaa aatcatgtcc cagagtcaag tatcgaaagg ggttgatttt gaatcaagtg     2280

aggatgatga tgatgatcct tttatgaaca ctagttcttt aagaagaaat agaagataat     2340

atatttaatg gcactgagaa acatgcaaga tacaggaaaa atgaaaatgt tacaagctaa     2400

gagtttacag tttaagattt taagtattgt ttcctgagca taactccata agtaagaaat     2460

ttctagttca cagacataca atagcattga ttcaccttgt ttttttaacc tggttgttgt     2520

agtaagagct ttgtttcaat atcactcttg agtaaagatt aaaataaagc taccatttta     2580

catttctatt tcataatgaa aaactatgtc agtattttaa tatggttaca tttagccaaa     2640

gttgagggaa agagcttata aaatttaact tcttcataat tttagtaatt tcctagaggt     2700

tctgggtttt ctgaaagtaa aacaatttat gcgaacctat gtctaaattc actgtttgtt     2760

actatgtatg tttttttcca atgcttctta taagactaaa tgattagaag tacctaatag     2820

tttgaacaga tatgttttta tttaaaagag tagaataacc tttcagaatt actgagtttt     2880

ttattccagt tgtagcaaag atttcaaaag attgtgttcc cattaagtgg tagtaatttc     2940

ctttattatt ctgtatcctt aatggtgttc tctctctctc tctctctctc tctctctccc     3000

tctccccccc gttccccact cttcctttct cctttgcttt ttcttctctt tcatacatat     3060

atgcgtgcct agttctagga ggaaacgggt taaaaattgt tttaaactac atcttgaaaa     3120

tattgaagaa tttgttttag gtagagtggt cagttgaacc ttacagtaaa gtatagaaat     3180

atatttaatg tggaatgtca atgccaggat ttctcattaa caatatttta tctcaacttt     3240

ggttcctgtg atacatttct gaatgggcaa ttccagaaat cttagtagcc catgttaagc     3300

ttctattttt tacttgtttt cggggagaaa taagaattag acatcttcag atttaagtta     3360

aataatccca ttctttataa tcctctgtaa aaagatccct gagattattc cttcttctag     3420

ttttatgcga cagctttact ttaaaattca agttatacat cttgggagta caatggcccg     3480

acatttcttc ataggtagaa acaaatactt gactcagtga tactcatgac cattagaata     3540

gtcatacctg gaatgtgtca aattataaga gacagacact tggttagtgg ctgcctcata     3600

tagcactttt gaagaggcct aagtcaaaac ttgcaatata acattctatt gactttctta     3660

aaaatatttt ttctgtacct aacttgagca taagggttat ttgagcaagt aacattaact     3720

cagtggaagg cattgtcctg tgaaatattc ttaggcagat ctgcccacat ctttattgaa     3780

cttgaaatct aatatttcta gtatttgaac aaagcagaag gttaagtcag ggaagagcag     3840

tgctgtccat gatgtaatgg aagctaccag gggaggcagt gtctggatga tgctgtgcta     3900

cctacccctg cacaagccat gctggctcag tctgagctgt gggccacatc agctagtggc     3960

tcttctcatg catcagttag gtgggtctgg gtgagagtta tagtgaggga atggtcacta     4020

aagtatcctg acaagttcct aggaaaaaag gaataaagtt tttttcctta aaaaaaaaaa     4080

aattgctctt ggctgtgaaa agaggtacta aatgcgattc agttcaccgc taaggaaagt     4140

gatgacatag cagttacaga gggtgataaa tctctccagc taattcaggt cattttgtga     4200

atactatgta tcaagccctg aaaatatggt aaataaaacg tgacagggaa accttttttt     4260

gattgaatat tgttacatag ttaaatgtgc tatatatcct taatatttta tattgatcct     4320

gcaaaatctg ttggttttag gggagttttg ttttttgttt ctaacaattt tcagacctgt     4380

tggtatagga atgtagaagt ctttcagatg atttgaaagc agctgcattt gctcttggag     4440

gctttgggag agcaggaatg aaaacattca gaggaagaca tctgtaggga attcttctgt     4500

tacttaccaa agaataagtg tctttctggt gttttatttc ctatcataaa aatacaacag     4560

tgcatttaca aggttaaaga ttcctcgaag ttctaggaaa ttcttgaaaa tataagtggt     4620

gcttagaaaa ttcaagcatt taggaatgtg acctttaatt caggtatgta aaagactttt     4680

ttcccaaact tttaaaagta ggaaatacaa taaatacaga aaagtcatat ggttgaataa     4740

ataattataa attgagcact gatggaatcc ctctacaggt caagaaatag cgcagtgtcc     4800

tggatgccca ttatattgtt ttctcctttc tgggtaacaa gccctaactt ctgtaattta     4860

aaagctccta cttttgccac aaggtggtgc ttctgccatt agacgcagtt aggaggatgc     4920

aactgcaaat ctaaaattac gaagttagtg tagttgcaat aaacttagaa catatgcatt     4980

aatactaaac ctatgcagta ataccataat tagccttcta atcatgtaat ttgctttact     5040

taggtatttc atttggttca gcctgttatg gaatttacca gcttgataaa tttgcctata     5100

aagttttata aagaaaagga atattttgtt ttcataaaga ggaaaatcca ttcttagaaa     5160

aaaa                                                                  5164


<210>  4
<211>  5826
<212>  DNA
<213>  homo sapiens

<400>  4
ccaggagagc ggcgtggacg cgtgcgggcc tagaggccca cgtgatccgc agggcggccg       60

aggcaggaag ctgtgagtgc gcggttgcgg ggtcgcattg tggctacggc tttgcgtccc      120

cggcgggcag ccccaggctg gtccccgcct ccgctctccc caccggcggg gaaagcagct      180

ggtgtgggag gaaaggctcc atcccccgcc ccctctctcc cgctgttggc tggcaggatc      240

ttttggcagt cctgtggcct cgctccccgc ccggatcctc ctgaccctga gattcgcggg      300

tctcacgtcc cgtgcacgcc ttgcttcggc ctcagttaag cctttgtgga ctccaggtcc      360

ctggtgagat tagaaacgtt tgcaaacatg tcccggatcg aaaagatgag cattctgggc      420

gtgcggagtt ttggaataga ggacaaagat aagcaaatta tcactttctt cagccccctt      480

acaattttgg ttggacccaa tggggcggga aagacgacca tcattgaatg tctaaaatat      540

atttgtactg gagatttccc tcctggaacc aaaggaaata catttgtaca cgatcccaag      600

gttgctcaag aaacagatgt gagagcccag attcgtctgc aatttcgtga tgtcaatgga      660

gaacttatag ctgtgcaaag atctatggca tggtgaaaag gtcagtctga gctctaagtg      720

tgcagaaatt gaccgagaaa tgatcagttc tcttggggtt tccaaggctg tgctaaataa      780

tgtcattttc tgtcatcaag aagattctaa ttggccttta agtgaaggaa aggctttgaa      840

gcaaaagttt gatgagattt tttcagcaac aagatacatt aaagccttag aaacacttcg      900

gcaggtacgt cagacacaag gtcagaaagt aaaagaatat caaatggaac taaaatatct      960

gaagcaatat aaggaaaaag cttgtgagat tcgtgatcag attacaagta aggaagccca     1020

gttaacatct tcaaaggaaa ttgtcaaatc ctatgagaat gaacttgatc cattgaagaa     1080

tcgtctaaaa gaaattgaac ataatctctc taaaataatg aaacttgaca atgaaattaa     1140

agccttggat agccgaaaga agcaaatgga gaaagataat agtgaactgg aagagaaaat     1200

ggaaaaggtt tttcaaggga ctgatgagca actaaatgac ttatatcaca atcaccagag     1260

aacagtaagg gagaaagaaa ggaaattggt agactgtcat cgtgaactgg aaaaactaaa     1320

taaagaatct aggcttctca atcaggaaaa atcagaactg cttgttgaac agggtcgtct     1380

acagctgcaa gcagatcgcc atcaagaaca tatccgagct agagattcat taattcagtc     1440

tttggcaaca cagctagaat tggatggctt tgagcgtgga ccattcagtg aaagacagat     1500

taaaaatttt cacaaacttg tgagagagag acaagaaggg gaagcaaaaa ctgccaacca     1560

actgatgaat gactttgcag aaaaagagac tctgaaacaa aaacagatag atgagataag     1620

agataagaaa actggactgg gaagaataat tgagttaaaa tcagaaatcc taagtaagaa     1680

gcagaatgag ctgaaaaatg tgaagtatga attacagcag ttggaaggat cttcagacag     1740

gattcttgaa ctggaccagg agctcataaa agctgaacgt gagttaagca aggctgagaa     1800

aaacagcaat gtagaaacct taaaaatgga agtaataagt ctccaaaatg aaaaagcaga     1860

cttagacagg accctgcgta aacttgacca ggagatggag cagttaaacc atcatacaac     1920

aacacgtacc caaatggaga tgctgaccaa agacaaagct gacaaagatg aacaaatcag     1980

aaaaataaaa tctaggcaca gtgatgaatt aacctcactg ttgggatatt ttcccaacaa     2040

aaaacagctt gaagactggc tacatagtaa atcaaaagaa attaatcaga ccagggacag     2100

acttgccaaa ttgaacaagg aactagcttc atctgagcag aataaaaatc atataaataa     2160

tgaactaaaa agaaaggaag agcagttgtc cagttacgaa gacaagctgt ttgatgtttg     2220

tggtagccag gattttgaaa gtgatttaga caggcttaaa gaggaaattg aaaaatcatc     2280

aaaacagcga gccatgctgg ctggagccac agcagtttac tcccagttca ttactcagct     2340

aacagacgaa aaccagtcat gttgccccgt ttgtcagaga gtttttcaga cagaggctga     2400

gttacaagaa gtcatcagtg atttgcagtc taaactgcga cttgctccag ataaactcaa     2460

gtcaacagaa tcagagctaa aaaaaaagga aaagcggcgt gatgaaatgc tgggacttgt     2520

gcccatgagg caaagcataa ttgatttgaa ggagaaggaa ataccagaat taagaaacaa     2580

actgcagaat gtcaatagag acatacagcg cctaaagaac gacatagaag aacaagaaac     2640

actcttgggt acaataatgc ctgaagaaga aagtgccaaa gtatgcctga cagatgttac     2700

aattatggag aggttccaga tggaacttaa agatgttgaa agaaaaattg cacaacaagc     2760

agctaagcta caaggaatag acttagatcg aactgtccaa caagtcaacc aggagaaaca     2820

agagaaacag cacaagttag acacagtttc tagtaagatt gaattgaatc gtaagcttat     2880

acaggaccag caggaacaga ttcaacatct aaaaagtaca acaaatgagc taaaatctga     2940

gaaacttcag atatccacta atttgcaacg tcgtcagcaa ctggaggagc agactgtgga     3000

attatccact gaagttcagt ctttgtacag agagataaag gatgctaaag agcaggtaag     3060

ccctttggaa acaacattgg aaaagttcca gcaagaaaaa gaagaattaa tcaacaaaaa     3120

aaatacaagc aacaaaatag cacaggataa actgaatgat attaaagaga aggttaaaaa     3180

tattcatggc tatatgaaag acattgagaa ttatattcaa gatgggaaag acgactataa     3240

gaagcaaaaa gaaactgaac ttaataaagt aatagctcaa ctaagtgaat gcgagaaaca     3300

caaagaaaag ataaatgaag atatgagact catgagacaa gatattgata cacagaagat     3360

acaagaaagg tggctacaag ataaccttac tttaagaaaa agaaatgagg aactaaaaga     3420

agttgaagaa gaaagaaaac aacatttgaa ggaaatgggt caaatgcagg ttttgcaaat     3480

gaaaagtgaa catcagaagt tggaagagaa catagacaat ataaaaagaa atcataattt     3540

ggcattaggg cgacagaaag gttatgaaga agaaattatt cattttaaga aagaacttcg     3600

agaaccacaa tttcgggatg ctgaggaaaa gtatagagaa atgatgattg ttatgaggac     3660

aacagaactt gtgaacaagg atctggatat ttattataag actcttgacc aagcaataat     3720

gaaatttcac agtatgaaaa tggaagaaat caataaaatt atacgtgacc tgtggcgaag     3780

tacctatcgt ggacaagata ttgaatacat agaaatacgg tctgatgccg atgaaaatgt     3840

atcagcttct gataaaaggc ggaattataa ctaccgagtg gtgatgctga agggagacac     3900

agccttggat atgcgaggac gatgcagtgc tggacaaaag gtattagcct cactcatcat     3960

tcgcctggcc ctggctgaaa cgttctgcct caactgtggc atcattgcct tggatgagcc     4020

aacaacaaat cttgaccgag aaaacattga atctcttgca catgctctgg ttgagataat     4080

aaaaagtcgc tcacagcagc gtaacttcca gcttctggta atcactcatg atgaagattt     4140

tgtggagctt ttaggacgtt ctgaatatgt ggagaaattc tacaggatta aaaagaacat     4200

cgatcagtgc tcagagattg tgaaatgcag tgttagctcc ctgggattca atgttcatta     4260

aaaatatcca agatttaaat gccatagaaa tgtaggtcct cagaaagtgt ataataagaa     4320

acttatttct catatcaact tagtcaataa gaaaatatat tctttcaaag gaacattgtg     4380

tctaggattt tggatgttga gaggttctaa aatcatgaaa cttgtttcac tgaaaattgg     4440

acagattgcc tgtttctgat ttgctgctct tcatcccatt ccaggcagcc tctgtcaggc     4500

cttcagggtt cagcagtaca gccgagactc gactctgtgc ctccctcccc agtgcaaatg     4560

catgcttctt ctcaaagcac tgttgagaag gagataatta ctgccttgaa aatttatggt     4620

tttggtattt ttttaaatca tagttaaatg ttacctctga atttacttcc ttgcatgtgg     4680

tttgaaaaac tgagtattaa tatctgagga tgaccagaaa tggtgagatg tatgtttggc     4740

tctgctttta actttataaa tccagtgacc tctctctctg ggacttggtt tccccaacta     4800

aaatttgaag tagttgaatg gggtctcaaa gtttgacagg aaccttaagt aatcatctaa     4860

gtcagtaccc accaccttct tctcctacat atcccttcca gatggtcatc cagactcaga     4920

gctctctcta cagagaggaa attctccact gtgcacaccc acctttggaa agctctgacc     4980

acttgaggcc tgatctgccc atcgtgaaga agcctgtaac actcctctgc gtctatcctg     5040

tgtagcatac tggcttcacc atcaatcctg attcctctct aagtgggcat tgccatgtgg     5100

aaggcaagcc aggctcactc acagagtcaa ggcctgctcc ctgtagggtc caaccagacc     5160

tggaagaaca ggcctctcca tttgctcttc agatgccact tctaagaaaa gcctaatcac     5220

agtttttcct ggaattgcca gctgacatct tgaatccttc cattccacac agaatgcaac     5280

caagtcacac gcttttgaat tatgctttgt agagttttgt cattcagagt cagccaggac     5340

cataccgggt cttgattcag tcacatggca tggttttgtg ccatctgtag ctataatgag     5400

catgtttgcc tagacagctt ttctcaactg ggtccagaag agaattaagc cctaaggtcc     5460

taaggcatct atctgtgcta ggttaaatgg ttggccccca aagatagaca ggtcctgatt     5520

tctagaaccc gtgactgtta ctttatacag caaaggaaac tttgcagatg tgattaaagc     5580

taaggacctt aagacagagt atcctggggg tggtggtggg gtgggggggg gtcctaaatg     5640

taatcacgag taagattaag agcaaatcaa ttctagtcat atattaaaca tccacaataa     5700

ccaagatatt tttatcccaa gaatgcaaga tttcagaaaa tgaaaaatct gttgataaat     5760

ccatcactat aataaaaccg aaggtgaaaa aaattctgaa aaaaaaaaaa aaaaaaaaaa     5820

aaaaaa                                                                5826


<210>  5
<211>  4437
<212>  DNA
<213>  Homo sapiens

<400>  5
gctcgtctag cagccccggt tacgcggttg cacgtcggcc ccagccctga ggagccggac       60

cgatgtggaa actgctgccc gccgcgggcc cggcaggagg agaaccatac agacttttga      120

ctggcgttga gtacgttgtt ggaaggaaaa actgtgccat tctaattgaa aatgatcagt      180

cgatcagccg aaatcatgct gtgttaactg ctaacttttc tgtaaccaac ctgagtcaaa      240

cagatgaaat ccctgtattg acattaaaag ataattctaa gtatggtacc tttgttaatg      300

aggaaaaaat gcagaatggc ttttcccgaa ctttgaagtc gggggatggt attacttttg      360

gagtgtttgg aagtaaattc agaatagagt atgagccttt ggttgcatgc tcttcttgtt      420

tagatgtctc tgggaaaact gctttaaatc aagctatatt gcaacttgga ggatttactg      480

taaacaattg gacagaagaa tgcactcacc ttgtcatggt atcagtgaaa gttaccatta      540

aaacaatatg tgcactcatt tgtggacgtc caattgtaaa gccagaatat tttactgaat      600

tcctgaaagc agttcagtcc aagaagcagc ctccacaaat tgaaagtttt tacccacctc      660

ttgatgaacc atctattgga agtaaaaatg ttgatctgtc aggacggcag gaaagaaaac      720

aaatcttcaa agggaaaaca tttatatttt tgaatgccaa acagcataag aaattgagtt      780

ccgcagttgt ctttggaggt ggggaagcta ggttgataac agaagagaat gaagaagaac      840

ataatttctt tttggctccg ggaacgtgtg ttgttgatac aggaataaca aactcacaga      900

ccttaattcc tgactgtcag aagaaatgga ttcagtcaat aatggatatg ctccaaaggc      960

aaggtcttag acctattcct gaagcagaaa ttggattggc ggtgattttc atgactacaa     1020

agaattactg tgatcttcag ggccatccca gtacaggatt aaagacaaca actccaggac     1080

caagcctttc acaaggcgtg tcagttgatg aaaaactaat gccaagcgcc ccagtgaaca     1140

ctacaacata cgtagctgac acagaatcag agcaagcaga tacatgggat ttgagtgaaa     1200

ggccaaaaga aatcaaagtc tccaaaatgg aacaaaaatt cagaatgctt tcacaagacg     1260

cacccactgt aaaggagtcc tgcaaaacaa gctctaataa taatagtatg gtatcaaata     1320

ctttggctaa gatgagaatc ccaaactatc agctttcacc aactaaattg ccaagtataa     1380

ataaaagtaa agatagggct tctcagcagc agcagaccaa ctccatcaga aactactttc     1440

agccgtctac caaaaaaagg gaaagggatg aagaaaatca agaaatgtct tcatgcaaat     1500

cagcaagaat agaaacgtct tgttctcttt tagaacaaac acaacctgct acaccctcat     1560

tgtggaaaaa taaggagcag catctatctg agaatgagcc tgtggacaca aactcagaca     1620

ataacttatt tacagataca gatttaaaat ctattgtgaa aaattctgcc agtaaatctc     1680

atgctgcaga aaagctaaga tcaaataaaa aaagggaaat ggatgatgtg gccatagaag     1740

atgaagtatt ggaacagtta ttcaaggaca caaaaccaga gttagaaatt gatgtgaaag     1800

ttcaaaaaca ggaggaagat gtcaatgtta gaaaaaggcc aaggatggat atagaaacaa     1860

atgacacttt cagtgatgaa gcagtaccag aaagtagcaa aatatctcaa gaaaatgaaa     1920

ttgggaagaa acgtgaactc aaggaagact cactatggtc agctaaagaa atatctaaca     1980

atgacaaact tcaggatgat agtgagatgc ttccaaaaaa gctgttattg actgaattta     2040

gatcactggt gattaaaaac tctacttcca gaaatccgtc tggcataaat gatgattatg     2100

gtcaactaaa aaatttcaag aaattcaaaa aggtcacata tcctggagca ggaaaacttc     2160

cacacatcat tggaggatca gatctaatag ctcatcatgc tcgaaagaat acagaactag     2220

aagagtggct aaggcaggaa atggaggtac aaaatcaaca tgcaaaagaa gagtctcttg     2280

ctgatgatct ttttagatac aatccttatt taaaaaggag aagataactg aggattttaa     2340

aaagaagcca tggaaaaact tcctagtaag catctacttc aggccaacaa ggttatatga     2400

atatatagtg tatagaagcg atttaagtta caatgtttta tggcctaaat ttattaaata     2460

aaatgcacaa aactttgatt cttttgtatg taacaattgt ttgttctgtt ttcaggcttt     2520

gtcattgcat ctttttttca tttttaaatg tgttttgttt attaaatagt taatatagtc     2580

acagttcaaa attctaaata tacgtaaggt aaagactaaa gtcacccttc caccattgtc     2640

ctagctactt ggttcccctc agaaaaaaat tcatgatact catttcttat gaatctttcc     2700

agggattttt gagtcctatt caaattccta tttttaaata atttcctaca caaatgatag     2760

cataacatat gcagtgttct acaccttgct tttttactta gtagattaaa aattatagga     2820

atatcaatat aatgttttta atattttttc ttttccatta tgctgtactc ttacctaaac     2880

tctggtgatc caaacaaaat ggcttcagtg gtgcagatgt cacctacatg ttattctagt     2940

actagaaact gaagaccatg tggagacttc atcaaacatg ggtttagttt tcaccagaat     3000

ggaaagacct gtaccccttt ttggtggtct tactgagctg ggtgggtgtc tgttttgagc     3060

ttatttagag tcctagtttt cctacttata aagtagaaat ggtgagattg ttttcttttt     3120

ctaccttaaa gggagatggt aagaaacaat gaatgtcttt tttcaaactt tattgacaag     3180

tgattttcaa gtctgtgttc aaaaatatat tcatgtacct gtgatccagc aagaagggag     3240

ttccagtcaa gagtcactac aactgattag ttgtttagag aatgagaaat ggaacagtga     3300

ggaatggagg ccatatttcc atgacttccc ttgtaaacag aagcaacaga agggacaaga     3360

ggctggcctc tacatcactc tcaccttcca aatcttgtgg aagtgcatct acttgccaga     3420

accaaattaa cttacttcca agttctggct gcttgcaggt ggaactccag ctgcaaggga     3480

gttagggaaa tgaaggtctt tttttaaaag cttctcagcc ttcctaggga acagacattg     3540

ggtgagccaa tctgcaattt ctactacagg cattgagacc agttagatta ttgaaatatt     3600

atagagagtt atgaacactt aaattatgat agtggtatga cattggatag aacatgggat     3660

actttagaag tagaattgac agggcatatt agttgatgaa atggagtcat ttgagtctct     3720

taatagccat gtatcataat taccaagtga agctggtgga acatatggtc tccattttac     3780

agttaaggaa tataatggac agattaatat tgttctctgt catgcccaca atccctttct     3840

aaggaagact gccctactat agcagttttt atatttgtca atttatgaat ataatgaatg     3900

agagttctgg tacctcctgt ctttacaaat attggtgttg tcagtatttt tcctttttaa     3960

ccattccaat cggtgtgtag tgatgtttca ttttggtttt aatttgtata tccctgatag     4020

ctataattgg gtcatagaaa ttctttatac attctagatg caagtctctt gtcggatata     4080

cgtattgaga tattacacct agtctgtggc ttgactgttt tctttatgtc ttttgatgaa     4140

tagaagtttt aaattttgac aaggtcaaat ttattttttt cttttgtttg atattttttc     4200

tctccaattt aaccccaaga tttcagatat tctgctctat tatataaact ttatattttt     4260

atatttgtga tctaccttga attgatatgt atgttgtgaa ttatggatca gggttctttt     4320

tttcccccat acaagtatcc agtcattgta acactgttta ttgaaagaat tatcctttcc     4380

tcattaaatt accttgccaa ttagtaaaaa atcaattaac caaaaaaaaa aaaaaaa        4437


<210>  6
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence that may be homologous or complimentary to an siRNA of 
       the present invention

<400>  6
acaggagaag agatcaact                                                    19


<210>  7
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence that may be homologous or complimentary to an siRNA of 
       the present invention

<400>  7
cctgcctcga gttattaag                                                    19


<210>  8
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence that may be homologous or complimentary to an siRNA of 
       the present invention

<400>  8
ctgcgagtgg actatagtg                                                    19


<210>  9
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence that may be homologous or complimentary to an siRNA of 
       the present invention

<400>  9
gatgccattg aggaattag                                                    19


<210>  10
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence that may be homologous or complimentary to an siRNA of 
       the present invention


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n=a,c,g,t or u

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n=a,c,g,t or u

<400>  10
gagcauaacu ccauaaguan tnt                                               23


<210>  11
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence that may be homologous or complimentary to an siRNA of 
       the rpesent invention

<400>  11
gcuaaugacu cugaugaua                                                    19


<210>  12
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence that may be homologous or complimentary to an siRNA of 
       the present invention

<400>  12
ggagaaggaa ataccagaa                                                    19


<210>  13
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence that may be homologous or complimentary to an siRNA of 
       the rpesent inventionr

<400>  13
gcagacttag acaggaccc                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Sequence that may be homologous or complimentary to an siRNA of 
       the present invention

<400>  14
gcucagagau ugugaaaug                                                    19


<210>  15
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence that may be homologous or complimentary to an siRNA of 
       the present invention

<400>  15
caggaggaag atgtcaatg                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Sequence that may be homologous or complimentary to an siRNA of 
       the present invention

<400>  16
gaagaaacgu gaacucaag                                                    19


<210>  17
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence that may be homologous or omplimentary to an siRNA of 
       the present invention


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n=a, c, g, t or u


<400>  17
ggcguuguca guugaugaaa ntt                                               23


<210>  18
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  One strand of an siRNA molecule

<400>  18
gctaatgact ctgatgata                                                    19


<210>  19
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  One strand of an siRNA molecule

<400>  19
gctcagagat tgtgaaatg                                                    19


<210>  20
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide sequence from the NBS1 C-terminus

<400>  20

Val Arg Glu Glu Ser Leu Ala Glu Asp Leu Phe Arg Tyr Asn Pro Lys 
1               5                   10                  15      


Pro Ser Lys Arg Arg Arg 
            20          


<210>  21
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide used as a control

<400>  21

Val Arg Ala Ala Ser Leu Ala Ala Ala Leu Phe Arg Tyr Asn Pro Lys 
1               5                   10                  15      


Pro Ser Lys Arg Arg Arg 
            20          


