                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  SPLICING FACTORS WITH A PUF PROTEIN RNA-BINDING DOMAIN AND A 
       SPLICING EFFECTOR DOMAIN AND USES OF SAME

<130>  705588

<150>  US 61/140,326
<151>  2008-12-23

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  2
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  2

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  3
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  3

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  4
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  4

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  5
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  5

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Cys Arg Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Glu Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr 
            340     


<210>  6
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  6

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Cys Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Cys Val Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Glu Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr 
            340     


<210>  7
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  7

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Cys Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Cys Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Cys Val Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Cys Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr 
            340     


<210>  8
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  8

Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly Phe 
1               5                   10                  15      


Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly Arg Gly 
            20                  25                  30          


Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser Gly Asp 
        35                  40                  45              


Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly Gly Gly 
    50                  55                  60                  


Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly 
65                  70                  75                  80  


Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly 
                85                  90                  95      


Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly Tyr Gly 
            100                 105                 110         


Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
        115                 120                 125     


<210>  9
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  9

Arg Gly Gly Asn Phe Gly Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn 
1               5                   10                  15      


Phe Gly Pro Gly Pro Gly Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr 
            20                  25                  30          


Gly Ser Gly Arg Gly Phe Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly 
        35                  40                  45              


Pro Gly Gly Gly Asn Phe Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg 
    50                  55                  60                  


Gly Gly Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly 
65                  70                  75                  80  


Tyr Gly Gly Gly Tyr Asp Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly 
                85                  90                  95      


Asn Tyr Asn Asp Phe Gly Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly 
            100                 105                 110         


Pro Met Lys Ser Gly Asn Phe Gly Gly Ser Arg Asn Met Gly Gly Pro 
        115                 120                 125             


Tyr Gly Gly Gly Asn Tyr Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Tyr Gly Gly Arg Ser Arg Tyr 
145                 150     


<210>  10
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  10

Gly Ser Gln Arg Gly Arg Gly Gly Gly Ser Gly Asn Phe Met Gly Arg 
1               5                   10                  15      


Gly Gly Asn Phe Gly Gly Gly Gly Gly Asn Phe Gly Arg Gly Gly Asn 
            20                  25                  30          


Phe Gly Gly Arg Gly Gly Tyr Gly Gly Gly Gly Gly Gly Ser Arg Gly 
        35                  40                  45              


Ser Tyr Gly Gly Gly Asp Gly Gly Tyr Asn Gly Phe Gly Gly Asp Gly 
    50                  55                  60                  


Gly Asn Tyr Gly Gly Gly Pro Gly Tyr Ser Ser Arg Gly Gly Tyr Gly 
65                  70                  75                  80  


Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly 
                85                  90                  95      


Gly Gly Tyr Asp Gly Tyr Asn Glu Gly Gly Asn Phe Gly Gly Gly Asn 
            100                 105                 110         


Tyr Gly Gly Gly Gly Asn Tyr Asn Asp Phe Gly Asn Tyr Ser Gly Gln 
        115                 120                 125             


Gln Gln Ser Asn Tyr Gly Pro Met Lys Gly Gly Ser Phe Gly Gly Arg 
    130                 135                 140                 


Ser Ser Gly Ser Pro Tyr Gly Gly Gly Tyr Gly Ser Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Tyr Gly Ser Arg Arg Phe 
                165             


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  11

Gly Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr 
1               5                   10                  15      


Gly Gly Gly 
            


<210>  12
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  12

Arg Ser Pro Ser Tyr Gly Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser 
1               5                   10                  15      


Arg Ser Arg Ser Arg Ser Asn Ser Arg Ser Arg Ser Tyr Ser Pro Arg 
            20                  25                  30          


Arg Ser Arg Gly Ser Pro Arg Tyr Ser Pro Arg His Ser Arg Ser Arg 
        35                  40                  45              


Ser Arg Thr 
    50      


<210>  13
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  13

Ser Arg Arg Arg Arg Ser Arg Ser Arg Ser Arg Ser His Ser Arg Ser 
1               5                   10                  15      


Arg Gly Arg Arg Tyr Ser Arg Ser Arg Ser Arg Ser Arg Gly Arg Arg 
            20                  25                  30          


Ser Arg Ser Ala Ser Pro Arg Arg Ser Arg Ser Ile Ser Leu Arg Arg 
        35                  40                  45              


Ser Arg Ser Ala Ser Leu Arg Arg Ser Arg Ser Gly Ser Ile Lys Gly 
    50                  55                  60                  


Ser Arg Tyr Phe Gln Ser Pro Ser Arg Ser Arg Ser Arg Ser Arg Ser 
65                  70                  75                  80  


Ile Ser Arg Pro Arg Ser Ser Arg Ser Lys Ser Arg Ser Pro Ser Pro 
                85                  90                  95      


Lys Arg Ser Arg Ser Pro Ser Gly Ser Pro Arg Arg Ser Ala Ser Pro 
            100                 105                 110         


Glu Arg Met Asp 
        115     


<210>  14
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  14

Arg Arg Ser Arg Ser Pro Arg Arg Arg Arg Arg Ser Arg Ser Arg Ser 
1               5                   10                  15      


Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Tyr Ser Arg Ser Lys 
            20                  25                  30          


Ser Arg Ser Arg Thr Arg Ser Arg Ser Arg Ser Thr Ser Lys Ser Arg 
        35                  40                  45              


Ser Ala Arg Arg Ser Lys Ser Lys Ser Ser Ser Val Ser Arg Ser Arg 
    50                  55                  60                  


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Pro Pro Pro Val Ser 
65                  70                  75                  80  


Lys Arg Glu Ser Lys Ser Arg Ser Arg Ser Lys Ser Pro Pro Lys Ser 
                85                  90                  95      


Pro Glu Glu Glu Gly Ala Val Ser Ser 
            100                 105 


<210>  15
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  15

Ser Lys Arg His Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Thr Arg 
1               5                   10                  15      


Ser Ser Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Lys Ser 
            20                  25                  30          


Tyr Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Lys Ser 
        35                  40                  45              


Arg Ser Val Ser Arg Ser Pro Val Pro Glu Lys Ser Gln Lys Arg Gly 
    50                  55                  60                  


Ser Ser Ser Arg Ser Lys Ser Pro Ala Ser Val Asp Arg Gln Arg Ser 
65                  70                  75                  80  


Arg Ser Arg Ser Arg Ser Arg Ser Val Asp Ser Gly Asn 
                85                  90              


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  16

Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser 
1               5                   10          


<210>  17
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
ccagaauugu auauauucg                                                    19


<210>  18
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
ccagaauugu auguauucg                                                    19


<210>  19
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
cccagauuug auauauucg                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
ccagaauugu gcguguucg                                                    19


<210>  21
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
uguacaua                                                                 8


<210>  22
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
uguacgua                                                                 8


<210>  23
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
uugacaua                                                                 8


<210>  24
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
ugugcgug                                                                 8


<210>  25
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  25

Asp Phe Ser Gln Asn Val Arg Tyr Cys Ser Thr Glu Ile Asp Arg Asn 
1               5                   10                  15      


Asn Ser Ser Ser Lys Asn Asp His Leu Lys Tyr Ser Arg Pro Ala Leu 
            20                  25                  30          


Ser Arg Asn Ser Arg Ser Phe Thr Arg Ser Asn Asn Val Leu Pro Thr 
        35                  40                  45              


Trp Ser Leu Asp Ser Asn Gly Glu Met Arg Ser Arg Leu Ser Leu Ser 
    50                  55                  60                  


Glu Val Leu Asp Ser Gly Asp Leu Met Lys Phe Ala Val Asp Lys Thr 
65                  70                  75                  80  


Gly Cys Gln Phe Leu Glu Lys Ala Val Lys Gly Ser Leu Thr Ser Tyr 
                85                  90                  95      


Gln Lys Phe Gln Leu Phe Glu Gln Val Ile Gly Arg Lys Asp Asp Phe 
            100                 105                 110         


Leu Lys Leu Ser Thr Asn Ile Phe Gly Asn Tyr Phe Val Gln Glu Ile 
        115                 120                 125             


Ile Gly Met Ser Leu Thr Thr Tyr Asp Asp Asp Asn Ile Lys Arg Gln 
    130                 135                 140                 


Glu Lys Leu Lys Asn Phe Ile Ser Ser Gln Met Thr Asp Met Cys Leu 
145                 150                 155                 160 


Asp Lys Phe Ala Cys Arg Val Ile Gln Ser Ser Leu Gln Asn Met Asp 
                165                 170                 175     


Leu Ser Leu Ala Cys Lys Leu Val Gln Ala Leu Pro Arg Asp Ala Arg 
            180                 185                 190         


Leu Ile Ala Ile Cys Val Asp Gln Asn Ala Asn His Val Ile Gln Lys 
        195                 200                 205             


Val Val Ala Val Ile Pro Leu Lys Asn Trp Glu Phe Ile Val Asp Phe 
    210                 215                 220                 


Val Ala Thr Pro Glu His Leu Arg Gln Ile Cys Phe Asp Lys Tyr Gly 
225                 230                 235                 240 


Cys Arg Val Val Gln Thr Ile Ile Glu Lys Leu Thr Ala Asp Ser Ile 
                245                 250                 255     


Asn Val Asp Leu Thr Ser Ala Ala Gln His Leu Arg Glu Arg Ala Leu 
            260                 265                 270         


Gln Arg Leu Met Thr Ser Val Thr Asn Arg Cys Gln Glu Leu Ala Thr 
        275                 280                 285             


Asn Glu Tyr Ala Asn Tyr Ile Ile Gln His Ile Val Ser Asn Asp Asp 
    290                 295                 300                 


Leu Ala Val Tyr Arg Glu Cys Ile Ile Glu Lys Cys Leu Met Arg Asn 
305                 310                 315                 320 


Leu Leu Ser Leu Ser Gln Glu Lys Phe Ala Ser His Val Val Glu Lys 
                325                 330                 335     


Ala Phe Leu His Ala Pro Met Glu Leu Leu Ala Glu Met Met Asp Glu 
            340                 345                 350         


Ile Phe Asp Gly Tyr Met Pro His Pro Gly Thr Gly Lys Asp Ala Leu 
        355                 360                 365             


Asp Ile Met Met Phe His Gln Phe Gly Asn Tyr Val Val Gln Cys Met 
    370                 375                 380                 


Leu Thr Ile Cys Cys Asp Ala Val Ser Gly Arg Arg Gln Thr Lys Glu 
385                 390                 395                 400 


Gly Ser Tyr Asp His Ala Asn Ser Phe Gln Val Trp Leu Lys Lys Leu 
                405                 410                 415     


His Ser Arg Val Thr Lys Glu Arg His Arg Leu Ser Arg Phe Ser Ser 
            420                 425                 430         


Gly Lys Lys Met Ile Glu Thr Leu Ala His Leu Arg Ser Thr His Pro 
        435                 440                 445             


Ile Tyr Gly Leu Gln Ser Ser Gly His Glu Ser Phe Lys Thr Asp Cys 
    450                 455                 460                 


Phe Ser Thr Ala Ser Glu His Asp Gly Leu Glu Leu Glu Lys Asn Gly 
465                 470                 475                 480 


Ile Glu Glu Gly Asn Leu Arg Leu Met Arg Thr Phe Ser Pro 
                485                 490                 


<210>  26
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  26

Asp Phe Ser Gln Asn Val Arg Cys Phe Ser Ala Asp Ile Asp Arg Ser 
1               5                   10                  15      


Lys Ser Tyr Gly Ser Ser Lys His Tyr His Leu Lys Tyr Ser Arg Pro 
            20                  25                  30          


Ala Leu Ser Arg Asn Ser Arg Ser Phe Thr Arg Ser Asn Asn Val Leu 
        35                  40                  45              


Pro Thr Trp Ser Leu Asp Ser Asn Gly Glu Met Arg Ser Arg Leu Ser 
    50                  55                  60                  


Leu Ser Glu Val Leu Asp Ser Gly Asp Leu Met Lys Phe Ala Val Asp 
65                  70                  75                  80  


Lys Thr Gly Cys Gln Phe Leu Glu Lys Ala Val Lys Gly Ser Leu Thr 
                85                  90                  95      


Ser Tyr Gln Lys Phe Gln Leu Phe Glu Gln Val Ile Gly Arg Lys Asp 
            100                 105                 110         


Asp Phe Leu Lys Leu Ser Thr Asn Ile Phe Gly Asn Tyr Leu Val Gln 
        115                 120                 125             


Ser Val Ile Gly Ile Ser Leu Ala Thr Asn Asp Asp Gly Tyr Thr Lys 
    130                 135                 140                 


Arg Gln Glu Lys Leu Lys Asn Phe Ile Ser Ser Gln Met Thr Asp Met 
145                 150                 155                 160 


Cys Leu Asp Lys Phe Ala Cys Arg Val Ile Gln Ser Ser Leu Gln Asn 
                165                 170                 175     


Met Asp Leu Ser Leu Ala Cys Lys Leu Val Gln Ala Leu Pro Arg Asp 
            180                 185                 190         


Ala Arg Leu Ile Ala Ile Cys Val Asp Gln Asn Ala Asn His Val Ile 
        195                 200                 205             


Gln Lys Val Val Ala Val Ile Pro Leu Lys Asn Trp Glu Phe Ile Val 
    210                 215                 220                 


Asp Phe Val Ala Thr Pro Glu His Leu Arg Gln Ile Cys Ser Asp Lys 
225                 230                 235                 240 


Tyr Gly Cys Arg Val Val Gln Thr Ile Ile Glu Lys Leu Thr Ala Asp 
                245                 250                 255     


Ser Met Asn Val Asp Leu Thr Ser Ala Ala Gln Asn Leu Arg Glu Arg 
            260                 265                 270         


Ala Leu Gln Arg Leu Met Thr Ser Val Thr Asn Arg Cys Gln Glu Leu 
        275                 280                 285             


Ala Thr Asn Glu Tyr Ala Asn Tyr Ile Ile Gln His Ile Val Ser Asn 
    290                 295                 300                 


Asp Asp Leu Ala Val Tyr Arg Glu Cys Ile Ile Glu Lys Cys Leu Met 
305                 310                 315                 320 


Arg Asn Leu Leu Ser Leu Ser Gln Glu Lys Phe Ala Ser His Val Val 
                325                 330                 335     


Glu Lys Ala Phe Leu His Ala Pro Leu Glu Leu Leu Ala Glu Met Met 
            340                 345                 350         


Asp Glu Ile Phe Asp Gly Tyr Ile Pro His Pro Asp Thr Gly Lys Asp 
        355                 360                 365             


Ala Leu Asp Ile Met Met Phe His Gln Phe Gly Asn Tyr Val Val Gln 
    370                 375                 380                 


Cys Met Leu Thr Ile Cys Cys Asp Ala Val Ser Gly Arg Arg Gln Thr 
385                 390                 395                 400 


Lys Glu Gly Gly Tyr Asp His Ala Ile Ser Phe Gln Asp Trp Leu Lys 
                405                 410                 415     


Lys Leu His Ser Arg Val Thr Lys Glu Arg His Arg Leu Ser Arg Phe 
            420                 425                 430         


Ser Ser Gly Lys Lys Met Ile Glu Thr Leu Ala Asn Leu Arg Ser Thr 
        435                 440                 445             


His Pro Ile Tyr Glu Leu Gln Ser Ser Gly His Asp Ser Phe Lys Thr 
    450                 455                 460                 


Asp Tyr Phe Ser Thr Ala Ser Glu His Asp Gly Pro Glu Leu Glu Lys 
465                 470                 475                 480 


Asn Gly Ile Glu Glu Gly Ser Leu Met Leu Glu Pro Arg Ser Asn Lys 
                485                 490                 495     


Ser Ser Val Ser Val Lys Phe Ser Ser Ser Gly Ser His Gly Asp Asp 
            500                 505                 510         


<210>  27
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  27

Met His Gln Ala His Ser Gln Ser Ile Arg Val Pro Val Gln Pro Ser 
1               5                   10                  15      


Ala Thr Gly Ile Phe Ser Asn Pro Tyr Arg Glu Pro Thr Thr Thr Asp 
            20                  25                  30          


Asp Leu Leu Thr Arg Tyr Arg Ala Asn Pro Ala Met Met Lys Asn Leu 
        35                  40                  45              


Lys Leu Ser Asp Ile Arg Gly Ala Leu Leu Lys Phe Ala Lys Asp Gln 
    50                  55                  60                  


Val Gly Ser Arg Phe Ile Gln Gln Glu Leu Ala Ser Ser Lys Asp Arg 
65                  70                  75                  80  


Phe Glu Lys Asp Ser Ile Phe Asp Glu Val Val Ser Asn Ala Asp Glu 
                85                  90                  95      


Leu Val Asp Asp Ile Phe Gly Asn Tyr Val Val Gln Lys Phe Phe Glu 
            100                 105                 110         


Tyr Gly Glu Glu Arg His Trp Ala Arg Leu Val Asp Ala Ile Ile Asp 
        115                 120                 125             


Arg Val Pro Glu Tyr Ala Phe Gln Met Tyr Ala Cys Arg Val Leu Gln 
    130                 135                 140                 


Lys Ala Leu Glu Lys Ile Asn Glu Pro Leu Gln Ile Lys Ile Leu Ser 
145                 150                 155                 160 


Gln Ile Arg His Val Ile His Arg Cys Met Lys Asp Gln Asn Gly Asn 
                165                 170                 175     


His Val Val Gln Lys Ala Ile Glu Lys Val Ser Pro Gln Tyr Val Gln 
            180                 185                 190         


Phe Ile Val Asp Thr Leu Leu Glu Ser Ser Asn Thr Ile Tyr Glu Met 
        195                 200                 205             


Ser Val Asp Pro Tyr Gly Cys Arg Val Val Gln Arg Cys Leu Glu His 
    210                 215                 220                 


Cys Ser Pro Ser Gln Thr Lys Pro Val Ile Gly Gln Ile His Lys Arg 
225                 230                 235                 240 


Phe Asp Glu Ile Ala Asn Asn Gln Tyr Gly Asn Tyr Val Val Gln His 
                245                 250                 255     


Val Ile Glu His Gly Ser Glu Glu Asp Arg Met Val Ile Val Thr Arg 
            260                 265                 270         


Val Ser Asn Asn Leu Phe Glu Phe Ala Thr His Lys Tyr Ser Ser Asn 
        275                 280                 285             


Val Ile Glu Lys Cys Leu Glu Gln Gly Ala Val Tyr His Lys Ser Met 
    290                 295                 300                 


Ile Val Gly Ala Ala Cys His His Gln Glu Gly Ser Val Pro Ile Val 
305                 310                 315                 320 


Val Gln Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met 
                325                 330                 335     


Phe Asp Gln Val Thr Ser Glu Gln Arg Arg Glu Leu Ile Leu Thr Val 
            340                 345                 350         


Arg Pro His Ile Pro Val Leu Arg Gln Phe Pro His Gly Lys His Ile 
        355                 360                 365             


Leu Ala Lys Leu Glu Lys Tyr Phe Gln Lys Pro Ala Val Met Ser Tyr 
    370                 375                 380                 


Pro Tyr Gln Asp Met Gln Gly Ser His 
385                 390             


<210>  28
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  28

Met His Gln Ala His Ser Gln Ser Ile Arg Val Pro Val Gln Pro Ser 
1               5                   10                  15      


Ala Thr Gly Ile Phe Ser Asn Pro Tyr Arg Glu Pro Thr Thr Thr Asp 
            20                  25                  30          


Asp Leu Leu Thr Arg Tyr Arg Ala Asn Pro Ala Met Met Lys Asn Leu 
        35                  40                  45              


Lys Leu Ser Asp Ile Arg Gly Ala Leu Leu Lys Phe Ala Lys Asp Gln 
    50                  55                  60                  


Val Gly Ser Arg Phe Ile Gln Gln Glu Leu Ala Ser Ser Lys Asp Arg 
65                  70                  75                  80  


Phe Glu Lys Asp Ser Ile Phe Asp Glu Val Val Ser Asn Ala Asp Glu 
                85                  90                  95      


Leu Val Asp Asp Ile Phe Gly Asn Tyr Val Val Gln Lys Phe Phe Glu 
            100                 105                 110         


Tyr Gly Glu Glu Arg His Trp Ala Arg Leu Val Asp Ala Ile Ile Asp 
        115                 120                 125             


Arg Val Pro Glu Tyr Ala Phe Gln Met Tyr Ala Cys Arg Val Leu Gln 
    130                 135                 140                 


Lys Ala Leu Glu Lys Ile Asn Glu Pro Leu Gln Ile Lys Ile Leu Ser 
145                 150                 155                 160 


Gln Ile Arg His Val Ile His Arg Cys Met Lys Asp Gln Asn Gly Asn 
                165                 170                 175     


His Val Ile Gln Lys Val Val Ala Val Ile Pro Leu Lys Asn Trp Glu 
            180                 185                 190         


Phe Ile Val Asp Phe Val Ala Thr Pro Glu His Leu Arg Gln Ile Cys 
        195                 200                 205             


Phe Asp Lys Tyr Gly Cys Arg Val Val Gln Thr Ile Ile Glu Lys Leu 
    210                 215                 220                 


Thr Ala Asp Ser Ile Asn Val Asp Leu Thr Ser Ala Ala Gln His Leu 
225                 230                 235                 240 


Arg Glu Arg Ala Leu Gln Arg Leu Met Thr Ser Val His Lys Arg Phe 
                245                 250                 255     


Asp Glu Ile Ala Asn Asn Gln Tyr Gly Asn Tyr Val Val Gln His Val 
            260                 265                 270         


Ile Glu His Gly Ser Glu Glu Asp Arg Met Val Ile Val Thr Arg Val 
        275                 280                 285             


Ser Asn Asn Leu Phe Glu Phe Ala Thr His Lys Tyr Ser Ser Asn Val 
    290                 295                 300                 


Ile Glu Lys Cys Leu Glu Gln Gly Ala Val Tyr His Lys Ser Met Ile 
305                 310                 315                 320 


Val Gly Ala Ala Cys His His Gln Glu Gly Ser Val Pro Ile Val Val 
                325                 330                 335     


Gln Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Phe 
            340                 345                 350         


Asp Gln Val Thr Ser Glu Gln Arg Arg Glu Leu Ile Leu Thr Val Arg 
        355                 360                 365             


Pro His Ile Pro Val Leu Arg Gln Phe Pro His Gly Lys His Ile Leu 
    370                 375                 380                 


Ala Lys Leu Glu Lys Tyr Phe Gln Lys Pro Ala Val Met Ser Tyr Pro 
385                 390                 395                 400 


Tyr Gln Asp Met Gln Gly Ser His 
                405             


<210>  29
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  29

Met His Gln Ala His Ser Gln Ser Ile Arg Val Pro Val Gln Pro Ser 
1               5                   10                  15      


Ala Thr Gly Ile Phe Ser Asn Pro Tyr Arg Glu Pro Thr Thr Thr Asp 
            20                  25                  30          


Asp Leu Leu Thr Arg Tyr Arg Ala Asn Pro Ala Met Met Lys Asn Leu 
        35                  40                  45              


Lys Leu Ser Asp Ile Arg Gly Ala Leu Leu Lys Phe Ala Lys Asp Gln 
    50                  55                  60                  


Val Gly Ser Arg Phe Ile Gln Gln Glu Leu Ala Ser Ser Lys Asp Arg 
65                  70                  75                  80  


Phe Glu Lys Asp Ser Ile Phe Asp Glu Val Val Ser Asn Ala Asp Glu 
                85                  90                  95      


Leu Val Asp Asp Ile Phe Gly Asn Tyr Val Val Gln Lys Phe Phe Glu 
            100                 105                 110         


Tyr Gly Glu Glu Arg His Trp Ala Arg Leu Val Asp Ala Ile Ile Asp 
        115                 120                 125             


Arg Val Pro Glu Tyr Ala Phe Gln Met Tyr Ala Cys Arg Val Leu Gln 
    130                 135                 140                 


Lys Ala Leu Glu Lys Ile Asn Glu Pro Leu Gln Ile Lys Ile Leu Ser 
145                 150                 155                 160 


Gln Ile Arg His Val Ile His Arg Cys Met Lys Asp Gln Asn Gly Asn 
                165                 170                 175     


His Val Val Gln Lys Ala Ile Glu Lys Val Ser Pro Gln Tyr Val Gln 
            180                 185                 190         


Phe Ile Val Asp Thr Leu Leu Glu Ser Ser Asn Thr Ile Tyr Glu Met 
        195                 200                 205             


Ser Val Asp Pro Tyr Gly Cys Arg Val Val Gln Arg Cys Leu Glu His 
    210                 215                 220                 


Leu Thr Ala Asp Ser Ile Asn Val Asp Leu Thr Ser Ala Ala Gln His 
225                 230                 235                 240 


Leu Arg Glu Arg Ala Leu Gln Arg Leu Met Thr Ser Val His Lys Arg 
                245                 250                 255     


Phe Asp Glu Ile Ala Asn Asn Gln Tyr Gly Asn Tyr Val Val Gln His 
            260                 265                 270         


Val Ile Glu His Gly Ser Glu Glu Asp Arg Met Val Ile Val Thr Arg 
        275                 280                 285             


Val Ser Asn Asn Leu Phe Glu Phe Ala Thr His Lys Tyr Ser Ser Asn 
    290                 295                 300                 


Val Ile Glu Lys Cys Leu Glu Gln Gly Ala Val Tyr His Lys Ser Met 
305                 310                 315                 320 


Ile Val Gly Ala Ala Cys His His Gln Glu Gly Ser Val Pro Ile Val 
                325                 330                 335     


Val Gln Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met 
            340                 345                 350         


Phe Asp Gln Val Thr Ser Glu Gln Arg Arg Glu Leu Ile Leu Thr Val 
        355                 360                 365             


Arg Pro His Ile Pro Val Leu Arg Gln Phe Pro His Gly Lys His Ile 
    370                 375                 380                 


Leu Ala Lys Leu Glu Lys Tyr Phe Gln Lys Pro Ala Val Met Ser Tyr 
385                 390                 395                 400 


Pro Tyr Gln Asp Met Gln Gly Ser His 
                405                 


<210>  30
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  30

Met His Gln Ala His Ser Gln Ser Ile Arg Val Pro Val Gln Pro Ser 
1               5                   10                  15      


Ala Thr Gly Ile Phe Ser Asn Pro Tyr Arg Glu Pro Thr Thr Thr Asp 
            20                  25                  30          


Asp Leu Leu Thr Arg Tyr Arg Ala Asn Pro Ala Met Met Lys Asn Leu 
        35                  40                  45              


Lys Leu Ser Asp Ile Arg Gly Ala Leu Leu Lys Phe Ala Lys Asp Gln 
    50                  55                  60                  


Val Gly Ser Arg Phe Ile Gln Gln Glu Leu Ala Ser Ser Lys Asp Arg 
65                  70                  75                  80  


Phe Glu Lys Asp Ser Ile Phe Asp Glu Val Val Ser Asn Ala Asp Glu 
                85                  90                  95      


Leu Val Asp Asp Ile Phe Gly Asn Tyr Val Val Gln Lys Phe Phe Glu 
            100                 105                 110         


Tyr Gly Glu Glu Arg His Trp Ala Arg Leu Val Asp Ala Ile Ile Asp 
        115                 120                 125             


Arg Val Pro Glu Tyr Ala Phe Gln Met Tyr Ala Cys Arg Val Leu Gln 
    130                 135                 140                 


Lys Ala Leu Glu Lys Ile Asn Glu Pro Leu Gln Ile Lys Ile Leu Ser 
145                 150                 155                 160 


Gln Ile Arg His Val Ile His Arg Cys Met Lys Asp Gln Asn Gly Asn 
                165                 170                 175     


His Val Ile Gln Lys Val Val Ala Val Ile Pro Leu Lys Asn Trp Glu 
            180                 185                 190         


Phe Ile Val Asp Phe Val Ala Thr Pro Glu His Leu Arg Gln Ile Cys 
        195                 200                 205             


Phe Asp Lys Tyr Gly Cys Arg Val Val Gln Thr Ile Ile Glu Lys Cys 
    210                 215                 220                 


Ser Pro Ser Gln Thr Lys Pro Val Ile Gly Gln Ile His Lys Arg Phe 
225                 230                 235                 240 


Asp Glu Ile Ala Asn Asn Gln Tyr Gly Asn Tyr Val Val Gln His Val 
                245                 250                 255     


Ile Glu His Gly Ser Glu Glu Asp Arg Met Val Ile Val Thr Arg Val 
            260                 265                 270         


Ser Asn Asn Leu Phe Glu Phe Ala Thr His Lys Tyr Ser Ser Asn Val 
        275                 280                 285             


Ile Glu Lys Cys Leu Glu Gln Gly Ala Val Tyr His Lys Ser Met Ile 
    290                 295                 300                 


Val Gly Ala Ala Cys His His Gln Glu Gly Ser Val Pro Ile Val Val 
305                 310                 315                 320 


Gln Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Phe 
                325                 330                 335     


Asp Gln Val Thr Ser Glu Gln Arg Arg Glu Leu Ile Leu Thr Val Arg 
            340                 345                 350         


Pro His Ile Pro Val Leu Arg Gln Phe Pro His Gly Lys His Ile Leu 
        355                 360                 365             


Ala Lys Leu Glu Lys Tyr Phe Gln Lys Pro Ala Val Met Ser Tyr Pro 
    370                 375                 380                 


Tyr Gln Asp Met Gln Gly Ser His 
385                 390         


<210>  31
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  31

His Gln Ala His Ser Gln Ser Ile Arg Val Pro Val Gln Pro Ser Ala 
1               5                   10                  15      


Thr Gly Ile Phe Ser Asn Pro Tyr Arg Glu Pro Thr Thr Thr Asp Asp 
            20                  25                  30          


Leu Leu Thr Arg Tyr Arg Ala Asn Pro Ala Met Met Lys Asn Leu Lys 
        35                  40                  45              


Leu Ser Asp Ile Arg Gly Ala Leu Leu Lys Phe Ala Lys Asp Gln Val 
    50                  55                  60                  


Gly Ser Arg Phe Ile Gln Gln Glu Leu Ala Ser Ser Lys Asp Arg Phe 
65                  70                  75                  80  


Glu Lys Asp Ser Ile Phe Asp Glu Val Val Ser Asn Ala Asp Glu Leu 
                85                  90                  95      


Val Asp Asp Ile Phe Gly Asn Tyr Val Val Gln Lys Phe Phe Glu Tyr 
            100                 105                 110         


Gly Glu Glu Arg His Trp Ala Arg Leu Val Asp Ala Ile Ile Asp Arg 
        115                 120                 125             


Val Pro Glu Tyr Ala Phe Gln Met Tyr Ala Cys Arg Val Leu Gln Lys 
    130                 135                 140                 


Ala Leu Glu Lys Ile Asn Glu Pro Leu Gln Ile Lys Ile Leu Ser Gln 
145                 150                 155                 160 


Ile Arg His Val Ile His Arg Cys Met Lys Asp Gln Asn Gly Asn His 
                165                 170                 175     


Val Val Gln Lys Ala Ile Ala Val Ile Pro Leu Lys Asn Trp Glu Phe 
            180                 185                 190         


Ile Val Asp Thr Leu Leu Glu Ser Ser Asn Thr Ile Tyr Glu Met Ser 
        195                 200                 205             


Val Asp Pro Tyr Gly Cys Arg Val Val Gln Arg Cys Leu Glu His Cys 
    210                 215                 220                 


Ser Pro Ser Gln Thr Lys Pro Val Ile Gly Gln Ile His Lys Arg Phe 
225                 230                 235                 240 


Asp Glu Ile Ala Asn Asn Gln Tyr Gly Asn Tyr Val Val Gln His Val 
                245                 250                 255     


Ile Glu His Gly Ser Glu Glu Asp Arg Met Val Ile Val Thr Arg Val 
            260                 265                 270         


Ser Asn Asn Leu Phe Glu Phe Ala Thr His Lys Tyr Ser Ser Asn Val 
        275                 280                 285             


Ile Glu Lys Cys Leu Glu Gln Gly Ala Val Tyr His Lys Ser Met Ile 
    290                 295                 300                 


Val Gly Ala Ala Cys His His Gln Glu Gly Ser Val Pro Ile Val Val 
305                 310                 315                 320 


Gln Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Phe 
                325                 330                 335     


Asp Gln Val Thr Ser Glu Gln Arg Arg Glu Leu Ile Leu Thr Val Arg 
            340                 345                 350         


Pro His Ile Pro Val Leu Arg Gln Phe Pro His Gly Lys His Ile Leu 
        355                 360                 365             


Ala Lys Leu Glu Lys Tyr Phe Gln Lys Pro Ala Val Met Ser Tyr Pro 
    370                 375                 380                 


Tyr Gln Asp Met Gln Gly Ser His 
385                 390         


<210>  32
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  32

His Gln Ala His Ser Gln Ser Ile Arg Val Pro Val Gln Pro Ser Ala 
1               5                   10                  15      


Thr Gly Ile Phe Ser Asn Pro Tyr Arg Glu Pro Thr Thr Thr Asp Asp 
            20                  25                  30          


Leu Leu Thr Arg Tyr Arg Ala Asn Pro Ala Met Met Lys Asn Leu Lys 
        35                  40                  45              


Leu Ser Asp Ile Arg Gly Ala Leu Leu Lys Phe Ala Lys Asp Gln Val 
    50                  55                  60                  


Gly Ser Arg Phe Ile Gln Gln Glu Leu Ala Ser Ser Lys Asp Arg Phe 
65                  70                  75                  80  


Glu Lys Asp Ser Ile Phe Asp Glu Val Val Ser Asn Ala Asp Glu Leu 
                85                  90                  95      


Val Asp Asp Ile Phe Gly Asn Tyr Val Val Gln Lys Phe Phe Glu Tyr 
            100                 105                 110         


Gly Glu Glu Arg His Trp Ala Arg Leu Val Asp Ala Ile Ile Asp Arg 
        115                 120                 125             


Val Pro Glu Tyr Ala Phe Gln Met Tyr Ala Cys Arg Val Leu Gln Lys 
    130                 135                 140                 


Ala Leu Glu Lys Ile Asn Glu Pro Leu Gln Ile Lys Ile Leu Ser Gln 
145                 150                 155                 160 


Ile Arg His Val Ile His Arg Cys Met Lys Asp Gln Asn Gly Asn His 
                165                 170                 175     


Val Val Gln Lys Ala Ile Glu Lys Val Ser Pro Gln Tyr Val Gln Phe 
            180                 185                 190         


Ile Val Asp Thr Leu Leu Glu Ser Ser Asn Thr Leu Arg Gln Ile Cys 
        195                 200                 205             


Ser Asp Lys Tyr Gly Cys Arg Val Val Gln Arg Cys Leu Glu His Cys 
    210                 215                 220                 


Ser Pro Ser Gln Thr Lys Pro Val Ile Gly Gln Ile His Lys Arg Phe 
225                 230                 235                 240 


Asp Glu Ile Ala Asn Asn Gln Tyr Gly Asn Tyr Val Val Gln His Val 
                245                 250                 255     


Ile Glu His Gly Ser Glu Glu Asp Arg Met Val Ile Val Thr Arg Val 
            260                 265                 270         


Ser Asn Asn Leu Phe Glu Phe Ala Thr His Lys Tyr Ser Ser Asn Val 
        275                 280                 285             


Ile Glu Lys Cys Leu Glu Gln Gly Ala Val Tyr His Lys Ser Met Ile 
    290                 295                 300                 


Val Gly Ala Ala Cys His His Gln Glu Gly Ser Val Pro Ile Val Val 
305                 310                 315                 320 


Gln Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Phe 
                325                 330                 335     


Asp Gln Val Thr Ser Glu Gln Arg Arg Glu Leu Ile Leu Thr Val Arg 
            340                 345                 350         


Pro His Ile Pro Val Leu Arg Gln Phe Pro His Gly Lys His Ile Leu 
        355                 360                 365             


Ala Lys Leu Glu Lys Tyr Phe Gln Lys Pro Ala Val Met Ser Tyr Pro 
    370                 375                 380                 


Tyr Gln Asp Met Gln Gly Ser His 
385                 390         


<210>  33
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
ugugccaua                                                                9


<210>  34
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
uguacaua                                                                 8


<210>  35
<211>  5472
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression vector

<400>  35
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactg      660

cgatcgcccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata      720

agcagagctc gtttagtgaa ccgtcagatc actagaagct ttattgcggt agtttatcac      780

agttaaattg ctaacgcagt cagtgcttct gacacaacag tctcgaactt aagctgcagt      840

gactctctta aggtagcctt gcagaagttg gtcgtgaggc actgggcagg taagtatcaa      900

ggttacaaga caggtttaag gagaccaata gaaactgggc ttgtcgagac agagaagact      960

cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac     1020

aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact     1080

ataggctagc ctcgagaatt cacgcgtggt acctctagag tcgacccggg cggccgcttc     1140

cctttagtga gggttaatgc ttcgagcaga catgataaga tacattgatg agtttggaca     1200

aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc     1260

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt     1320

tatgtttcag gttcaggggg agatgtggga ggttttttaa agcaagtaaa acctctacaa     1380

atgtggtaaa atccgataag gatcgatccg ggctggcgta atagcgaaga ggcccgcacc     1440

gatcgccctt cccaacagtt gcgcagcctg aatggcgaat ggacgcgccc tgtagcggcg     1500

cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc     1560

tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc     1620

gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg     1680

accccaaaaa acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg     1740

tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg     1800

gaacaacact caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt     1860

cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa     1920

tattaacgct tacaatttcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc     1980

acaccgcata cgcggatctg cgcagcacca tggcctgaaa taacctctga aagaggaact     2040

tggttaggta ccttctgagg cggaaagaac cagctgtgga atgtgtgtca gttagggtgt     2100

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca     2160

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     2220

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     2280

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     2340

gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     2400

ggcttttgca aaaagcttga ttcttctgac acaacagtct cgaacttaag gctagagcca     2460

ccatgattga acaagatgga ttgcacgcag gttctccggc cgcttgggtg gagaggctat     2520

tcggctatga ctgggcacaa cagacaatcg gctgctctga tgccgccgtg ttccggctgt     2580

cagcgcaggg gcgcccggtt ctttttgtca agaccgacct gtccggtgcc ctgaatgaac     2640

tgcaggacga ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct tgcgcagctg     2700

tgctcgacgt tgtcactgaa gcgggaaggg actggctgct attgggcgaa gtgccggggc     2760

aggatctcct gtcatctcac cttgctcctg ccgagaaagt atccatcatg gctgatgcaa     2820

tgcggcggct gcatacgctt gatccggcta cctgcccatt cgaccaccaa gcgaaacatc     2880

gcatcgagcg agcacgtact cggatggaag ccggtcttgt cgatcaggat gatctggacg     2940

aagagcatca ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg cgcatgcccg     3000

acggcgagga tctcgtcgtg acccatggcg atgcctgctt gccgaatatc atggtggaaa     3060

atggccgctt ttctggattc atcgactgtg gccggctggg tgtggcggac cgctatcagg     3120

acatagcgtt ggctacccgt gatattgctg aagagcttgg cggcgaatgg gctgaccgct     3180

tcctcgtgct ttacggtatc gccgctcccg attcgcagcg catcgccttc tatcgccttc     3240

ttgacgagtt cttctgagcg ggactctggg gttcgaaatg accgaccaag cgacgcccaa     3300

cctgccatca cgatggccgc aataaaatat ctttattttc attacatctg tgtgttggtt     3360

ttttgtgtga atcgatagcg ataaggatcc gcgtatggtg cactctcagt acaatctgct     3420

ctgatgccgc atagttaagc cagccccgac acccgccaac acccgctgac gcgccctgac     3480

gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca     3540

tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac     3600

gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca ggtggcactt     3660

ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt     3720

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta     3780

tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg     3840

tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac     3900

gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg     3960

aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc     4020

gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg     4080

ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat     4140

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg     4200

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg     4260

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc     4320

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt     4380

cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct     4440

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc     4500

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca     4560

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct     4620

cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt     4680

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga     4740

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca     4800

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac     4860

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg     4920

taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag     4980

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac     5040

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt     5100

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg     5160

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc     5220

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc     5280

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     5340

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa     5400

acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgg     5460

ctcgacagat ct                                                         5472


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  36

Met Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5                   


<210>  37
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bacteriophage MS2

<400>  37

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Glu Glu Leu Pro Val 
65                  70                  75                  80  


Ala Gly Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr 
    130 


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  38

Pro Pro Lys Lys Lys Arg Lys Val 
1               5               


<210>  39
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  39

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Arg Glu Leu Tyr Pro Ala 
1               5                   10                  15      


Thr Met Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
            20                  25                  30          


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
        35                  40                  45              


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
    50                  55                  60                  


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
                85                  90                  95      


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
            100                 105                 110         


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly 
        115                 120                 125             


Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
    130                 135                 140                 


Pro Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg 
145                 150                 155                 160 


Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln 
                165                 170                 175     


Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His 
            180                 185                 190         


Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu 
        195                 200                 205             


Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met 
    210                 215                 220                 


Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly 
225                 230                 235                 240 


Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val 
                245                 250                 255     


Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala 
            260                 265                 270         


Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu 
        275                 280                 285             


Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val 
    290                 295                 300                 


Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile 
305                 310                 315                 320 


Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr 
                325                 330                 335     


Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln 
            340                 345                 350         


Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val 
        355                 360                 365             


Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly 
    370                 375                 380                 


Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val 
385                 390                 395                 400 


Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys 
                405                 410                 415     


Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val 
            420                 425                 430         


Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys 
        435                 440                 445             


Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu 
    450                 455                 460                 


Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala 
465                 470                 475                 480 


Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu 
                485                 490                 495     


Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            500                 505         


<210>  40
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  40

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Arg Glu Leu Tyr Pro Ala 
1               5                   10                  15      


Thr Met Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
            20                  25                  30          


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
        35                  40                  45              


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
    50                  55                  60                  


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
                85                  90                  95      


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
            100                 105                 110         


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly 
        115                 120                 125             


Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
    130                 135                 140                 


Pro Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg 
145                 150                 155                 160 


Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln 
                165                 170                 175     


Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His 
            180                 185                 190         


Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu 
        195                 200                 205             


Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met 
    210                 215                 220                 


Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly 
225                 230                 235                 240 


Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val 
                245                 250                 255     


Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala 
            260                 265                 270         


Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu 
        275                 280                 285             


Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val 
    290                 295                 300                 


Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile 
305                 310                 315                 320 


Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr 
                325                 330                 335     


Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln 
            340                 345                 350         


Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val 
        355                 360                 365             


Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly 
    370                 375                 380                 


Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val 
385                 390                 395                 400 


Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys 
                405                 410                 415     


Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val 
            420                 425                 430         


Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys 
        435                 440                 445             


Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu 
    450                 455                 460                 


Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala 
465                 470                 475                 480 


Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu 
                485                 490                 495     


Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            500                 505         


<210>  41
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  41

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Arg Glu Leu Tyr Pro Ala 
1               5                   10                  15      


Thr Met Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
            20                  25                  30          


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
        35                  40                  45              


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
    50                  55                  60                  


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
                85                  90                  95      


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
            100                 105                 110         


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly 
        115                 120                 125             


Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
    130                 135                 140                 


Pro Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg 
145                 150                 155                 160 


Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln 
                165                 170                 175     


Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His 
            180                 185                 190         


Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu 
        195                 200                 205             


Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met 
    210                 215                 220                 


Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly 
225                 230                 235                 240 


Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val 
                245                 250                 255     


Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala 
            260                 265                 270         


Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu 
        275                 280                 285             


Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val 
    290                 295                 300                 


Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile 
305                 310                 315                 320 


Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr 
                325                 330                 335     


Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln 
            340                 345                 350         


Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val 
        355                 360                 365             


Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu His Gly 
    370                 375                 380                 


Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val 
385                 390                 395                 400 


Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln Lys Cys 
                405                 410                 415     


Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val 
            420                 425                 430         


Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys 
        435                 440                 445             


Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu 
    450                 455                 460                 


Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala 
465                 470                 475                 480 


Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu 
                485                 490                 495     


Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            500                 505         


<210>  42
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  42

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Leu Glu Arg Ser Pro Ser 
1               5                   10                  15      


Tyr Gly Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser 
            20                  25                  30          


Arg Ser Asn Ser Arg Ser Arg Ser Tyr Ser Pro Arg Arg Ser Arg Gly 
        35                  40                  45              


Ser Pro Arg Tyr Ser Pro Arg His Ser Arg Ser Arg Ser Arg Thr Arg 
    50                  55                  60                  


Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg 
65                  70                  75                  80  


Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg 
                85                  90                  95      


Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser 
            100                 105                 110         


Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln 
        115                 120                 125             


Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp 
    130                 135                 140                 


Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu 
145                 150                 155                 160 


Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser 
                165                 170                 175     


Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala Leu Glu 
            180                 185                 190         


Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly 
        195                 200                 205             


His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln 
    210                 215                 220                 


Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp 
225                 230                 235                 240 


Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys 
                245                 250                 255     


Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu 
            260                 265                 270         


Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp 
        275                 280                 285             


Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro 
    290                 295                 300                 


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val 
305                 310                 315                 320 


Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr 
                325                 330                 335     


His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr 
            340                 345                 350         


Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln 
        355                 360                 365             


Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly 
    370                 375                 380                 


Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu 
385                 390                 395                 400 


Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr 
                405                 410                 415     


Tyr Met Lys Asn Gly Val Asp Leu Gly 
            420                 425 


<210>  43
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  43

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Leu Glu Arg Ser Pro Ser 
1               5                   10                  15      


Tyr Gly Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser 
            20                  25                  30          


Arg Ser Asn Ser Arg Ser Arg Ser Tyr Ser Pro Arg Arg Ser Arg Gly 
        35                  40                  45              


Ser Pro Arg Tyr Ser Pro Arg His Ser Arg Ser Arg Ser Arg Thr Arg 
    50                  55                  60                  


Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg 
65                  70                  75                  80  


Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg 
                85                  90                  95      


Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser 
            100                 105                 110         


Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln 
        115                 120                 125             


Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp 
    130                 135                 140                 


Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu 
145                 150                 155                 160 


Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser 
                165                 170                 175     


Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu 
            180                 185                 190         


Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly 
        195                 200                 205             


His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln 
    210                 215                 220                 


Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp 
225                 230                 235                 240 


Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys 
                245                 250                 255     


Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu 
            260                 265                 270         


Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp 
        275                 280                 285             


Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro 
    290                 295                 300                 


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val 
305                 310                 315                 320 


Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr 
                325                 330                 335     


His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr 
            340                 345                 350         


Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln 
        355                 360                 365             


Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly 
    370                 375                 380                 


Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu 
385                 390                 395                 400 


Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr 
                405                 410                 415     


Tyr Met Lys Asn Gly Val Asp Leu Gly 
            420                 425 


<210>  44
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  44

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Leu Glu Arg Ser Pro Ser 
1               5                   10                  15      


Tyr Gly Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser 
            20                  25                  30          


Arg Ser Asn Ser Arg Ser Arg Ser Tyr Ser Pro Arg Arg Ser Arg Gly 
        35                  40                  45              


Ser Pro Arg Tyr Ser Pro Arg His Ser Arg Ser Arg Ser Arg Thr Arg 
    50                  55                  60                  


Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg 
65                  70                  75                  80  


Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg 
                85                  90                  95      


Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser 
            100                 105                 110         


Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln 
        115                 120                 125             


Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp 
    130                 135                 140                 


Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu 
145                 150                 155                 160 


Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser 
                165                 170                 175     


Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala Leu Glu 
            180                 185                 190         


Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly 
        195                 200                 205             


His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln 
    210                 215                 220                 


Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp 
225                 230                 235                 240 


Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys 
                245                 250                 255     


Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu 
            260                 265                 270         


Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp 
        275                 280                 285             


Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro 
    290                 295                 300                 


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val 
305                 310                 315                 320 


Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln Lys Cys Val Thr 
                325                 330                 335     


His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr 
            340                 345                 350         


Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln 
        355                 360                 365             


Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly 
    370                 375                 380                 


Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu 
385                 390                 395                 400 


Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr 
                405                 410                 415     


Tyr Met Lys Asn Gly Val Asp Leu Gly 
            420                 425 


<210>  45
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  45

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Arg Glu Leu Tyr Pro Ala 
1               5                   10                  15      


Thr Met Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
            20                  25                  30          


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
        35                  40                  45              


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
    50                  55                  60                  


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
                85                  90                  95      


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
            100                 105                 110         


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly 
        115                 120                 125             


Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
    130                 135                 140                 


Pro Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg 
145                 150                 155                 160 


Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln 
                165                 170                 175     


Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His 
            180                 185                 190         


Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu 
        195                 200                 205             


Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met 
    210                 215                 220                 


Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly 
225                 230                 235                 240 


Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val 
                245                 250                 255     


Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala 
            260                 265                 270         


Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu 
        275                 280                 285             


Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val 
    290                 295                 300                 


Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile 
305                 310                 315                 320 


Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr 
                325                 330                 335     


Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro Asp Gln 
            340                 345                 350         


Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val 
        355                 360                 365             


Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly 
    370                 375                 380                 


Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val 
385                 390                 395                 400 


Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys 
                405                 410                 415     


Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val 
            420                 425                 430         


Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys 
        435                 440                 445             


Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu 
    450                 455                 460                 


Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala 
465                 470                 475                 480 


Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu 
                485                 490                 495     


Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            500                 505         


<210>  46
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  46
cacggatcct cccccccaag aaaaagagga aggtatctag aggccgcagc cgccttttg        59


<210>  47
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  47
gtggtcgact taccctaagt caacacc                                           27


<210>  48
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  48
cacgctagca tggactacaa ggacgacgat gacaagggtc tcgagagaag tccaagttat       60

ggaag                                                                   65


<210>  49
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  49
cacggatccc cgtacgagag cgagatctg                                         29


<210>  50
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  50
attgcaccac ccgaaacacc tgactccaaa gttcgtatgg ttatcatcac tggaccgcca       60

gaggcccaat tcaag                                                        75


<210>  51
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  n is a , c, g, or t

<220>
<221>  misc_feature
<222>  (13)..(20)
<223>  n is a, c, g, or t

<400>  51
cacctcgaga atnnnnnnnn ttcgggcccc ac                                     32


<210>  52
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (13)..(20)
<223>  n is a, c, g, or t

<400>  52
gtggggcccg aannnnnnnn attctcgagg tg                                     32


<210>  53
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  53
cacctcgaga attgtacata ttcgggcccc ac                                     32


<210>  54
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  54
cacctcgaga attgtacgta ttcgggcccc ac                                     32


<210>  55
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  55
cacctcgaga atttgacata ttcgggcccc ac                                     32


<210>  56
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  56
cacctcgaga attgtgcgtg ttcgggcccc ac                                     32


<210>  57
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  57
gtggggcccg aatatgtaca attctcgagg tg                                     32


<210>  58
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  58
gtggggcccg aatacgtaca attctcgagg tg                                     32


<210>  59
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  59
gtggggcccg aatatgtcaa attctcgagg tg                                     32


<210>  60
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  60
gtggggcccg aacacgcaca attctcgagg tg                                     32


<210>  61
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  61
agtgcttcag ccgctaccc                                                    19


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  62
gttgtactcc agcttgtgcc                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic pimer

<400>  63
catggcagca gtaaagcaag                                                   20


<210>  64
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic pimer

<400>  64
gcattgttcc catagagttc c                                                 21


<210>  65
<211>  10455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression vector

<400>  65
ttggaagggc taattcactc ccaaagaaga caagatatcc ttgatctgtg gatctaccac       60

acacaaggct acttccctga ttagcagaac tacacaccag ggccaggggt cagatatcca      120

ctgacctttg gatggtgcta caagctagta ccagttgagc cagataaggt agaagaggcc      180

aataaaggag agaacaccag cttgttacac cctgtgagcc tgcatgggat ggatgacccg      240

gagagagaag tgttagagtg gaggtttgac agccgcctag catttcatca cgtggcccga      300

gagctgcatc cggagtactt caagaactgc tgatatcgag cttgctacaa gggactttcc      360

gctggggact ttccagggag gcgtggcctg ggcgggactg gggagtggcg agccctcaga      420

tcctgcatat aagcagctgc tttttgcctg tactgggtct ctctggttag accagatctg      480

agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc      540

ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct      600

cagacccttt tagtcagtgt ggaaaatctc tagcagtggc gcccgaacag ggacttgaaa      660

gcgaaaggga aaccagagga gctctctcga cgcaggactc ggcttgctga agcgcgcacg      720

gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag cggaggctag      780

aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgcgatgg      840

gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca tatagtatgg      900

gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac atcagaaggc      960

tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga agaacttaga     1020

tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga gataaaagac     1080

accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac caccgcacag     1140

caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt ggagaagtga     1200

attatataaa tataaagtag taaaaattga accattagga gtagcaccca ccaaggcaaa     1260

gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt tccttgggtt     1320

cttgggagca gcaggaagca ctatgggcgc agcgtcaatg acgctgacgg tacaggccag     1380

acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta ttgaggcgca     1440

acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa gaatcctggc     1500

tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct ctggaaaact     1560

catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc tggaacagat     1620

ttggaatcac acgacctgga tggagtggga cagagaaatt aacaattaca caagcttaat     1680

acactcctta attgaagaat cgcaaaacca gcaagaaaag aatgaacaag aattattgga     1740

attagataaa tgggcaagtt tgtggaattg gtttaacata acaaattggc tgtggtatat     1800

aaaattattc ataatgatag taggaggctt ggtaggttta agaatagttt ttgctgtact     1860

ttctatagtg aatagagtta ggcagggata ttcaccatta tcgtttcaga cccacctccc     1920

aaccccgagg ggacccgaca ggcccgaagg aatagaagaa gaaggtggag agagagacag     1980

agacagatcc attcgattag tgaacggatc tcgacggtat cgatgtcgac gataagcttt     2040

gcaaagatgg ataaagtttt aaacagagag gaatctttgc agctaatgga ccttctaggt     2100

cttgaaagga gtgggaattg gctccggtgc ccgtcagtgg gcagagcgca catcgcccac     2160

agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg     2220

cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg     2280

agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc     2340

cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg     2400

cccttgcgtg ccttgaatta cttccactgg ctgcagtacg tgattcttga tcccgagctt     2460

cgggttggaa gtgggtggga gagttcgagg ccttgcgctt aaggagcccc ttcgcctcgt     2520

gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg gtggcacctt     2580

cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg atgacctgct     2640

gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaagatct gcacactggt     2700

atttcggttt ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg cacatgttcg     2760

gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc tcaagctggc     2820

cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg ggcggcaagg     2880

ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg ccctgctgca     2940

gggagctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc acccacacaa     3000

aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg actccacgga gtaccgggcg     3060

ccgtccaggc acctcgatta gttctcgagc ttttggagta cgtcgtcttt aggttggggg     3120

gaggggtttt atgcgatgga gtttccccac actgagtggg tggagactga agttaggcca     3180

gcttggcact tgatgtaatt ctccttggaa tttgcccttt ttgagtttgg atcttggttc     3240

attctcaagc ctcagacagt ggttcaaagt ttttttcttc catttcaggt gtcgtgagga     3300

atttcgacat ttaaatttaa ttaatctcga cggtatcggt taacttttaa aagaaaaggg     3360

gggattgggg ggtacagtgc aggggaaaga atagtagaca taatagcaac agacatacaa     3420

actaaagaat tacaaaaaca aattacaaaa attcaaaatt ttccgatcac gagactagcc     3480

tcgaggttta aactacggga tccaggccta agcttacgcg tcctagcgct accggtcgcc     3540

accatggtga gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg     3600

gacggcgacg taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc     3660

tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc     3720

accctcgtga ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg     3780

aagcagcacg acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc     3840

ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc     3900

ctggtgaacc gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg     3960

cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga caagcagaag     4020

aacggcatca aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc     4080

gccgaccact accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac     4140

cactacctga gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg     4200

gtcctgctgg agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag     4260

tccggactca gatctcgata gctagtagct agctagctag tcgagctcaa cttcgaattc     4320

ccgggactag tcatatgata atcaacctct ggattacaaa atttgtgaaa gattgactgg     4380

tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta     4440

tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct     4500

gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt     4560

tgctgacgca acccccactg gttggggcat tgccaccacc tgtcagctcc tttccgggac     4620

tttcgctttc cccctcccta ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg     4680

ctggacaggg gctcggctgt tgggcactga caattccgtg gtgttgtcgg ggaagctgac     4740

gtcctttcca tggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg     4800

ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct     4860

gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt cggatctccc tttgggccgc     4920

ctccccgcat cggtacgtat ggccaggtac ctttaagacc aatgacttac aaggcagctg     4980

tagatcttag ccacttttta aaagaaaagg ggggactgga agggctaatt cactcccaac     5040

gaagacaaga tctgcttttt gcttgtactg ggtctctctg gttagaccag atctgagcct     5100

gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag     5160

tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac     5220

ccttttagtc agtgtggaaa atctctagca gcatctagaa ttaattccgt gtattctata     5280

gtgtcaccta aatcgtatgt gtatgataca taaggttatg tattaattgt agccgcgttc     5340

taacgacaat atgtacaagc ctaattgtgt agcatctggc ttactgaagc agaccctatc     5400

atctctctcg taaactgccg tcagagtcgg tttggttgga cgaaccttct gagtttctgg     5460

taacgccgtc ccgcacccgg aaatggtcag cgaaccaatc agcagggtca tcgctagcca     5520

gatcctctac gccggacgca tcgtggccgg catcaccggc gccacaggtg cggttgctgg     5580

cgcctatatc gccgacatca ccgatgggga agatcgggct cgccacttcg ggctcatgag     5640

cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc gggggactgt tgggcgccat     5700

ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac ggcctcaacc tactactggg     5760

ctgcttccta atgcaggagt cgcataaggg agagcgtcga atggtgcact ctcagtacaa     5820

tctgctctga tgccgcatag ttaagccagc cccgacaccc gccaacaccc gctgacgcgc     5880

cctgacgggc ttgtctgctc ccggcatccg cttacagaca agctgtgacc gtctccggga     5940

gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg cgcgagacga aagggcctcg     6000

tgatacgcct atttttatag gttaatgtca tgataataat ggtttcttag acgtcaggtg     6060

gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa     6120

atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga     6180

agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc     6240

ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg     6300

gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc     6360

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat     6420

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg     6480

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag     6540

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa     6600

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc     6660

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca     6720

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc     6780

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc     6840

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg     6900

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta     6960

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag     7020

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga     7080

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc     7140

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa     7200

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa     7260

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     7320

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt     7380

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     7440

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     7500

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     7560

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcat tgagaaagcg     7620

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     7680

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     7740

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     7800

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     7860

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     7920

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     7980

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     8040

gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag     8100

tatgcaaagc atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc     8160

agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct     8220

aactccgccc atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg     8280

actaattttt tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa     8340

gtagtgagga ggcttttttg gaggcctagg cttttgcaaa aagcttggac acaagacagg     8400

cttgcgagat atgtttgaga ataccacttt atcccgcgtc agggagaggc agtgcgtaaa     8460

aagacgcgga ctcatgtgaa atactggttt ttagtgcgcc agatctctat aatctcgcgc     8520

aacctatttt cccctcgaac actttttaag ccgtagataa acaggctggg acacttcaca     8580

tgagcgaaaa atacatcgtc acctgggaca tgttgcagat ccatgcacgt aaactcgcaa     8640

gccgactgat gccttctgaa caatggaaag gcattattgc cgtaagccgt ggcggtctgt     8700

accgggtgcg ttactggcgc gtgaactggg tattcgtcat gtcgataccg tttgtatttc     8760

cagctacgat cacgacaacc agcgcgagct taaagtgctg aaacgcgcag aaggcgatgg     8820

cgaaggcttc atcgttattg atgacctggt ggataccggt ggtactgcgg ttgcgattcg     8880

tgaaatgtat ccaaaagcgc actttgtcac catcttcgca aaaccggctg gtcgtccgct     8940

ggttgatgac tatgttgttg atatcccgca agatacctgg attgaacagc cgtgggatat     9000

gggcgtcgta ttcgtcccgc caatctccgg tcgctaatct tttcaacgcc tggcactgcc     9060

gggcgttgtt ctttttaact tcaggcgggt tacaatagtt tccagtaagt attctggagg     9120

ctgcatccat gacacaggca aacctgagcg aaaccctgtt caaaccccgc tttaaacatc     9180

ctgaaacctc gacgctagtc cgccgcttta atcacggcgc acaaccgcct gtgcagtcgg     9240

cccttgatgg taaaaccatc cctcactggt atcgcatgat taaccgtctg atgtggatct     9300

ggcgcggcat tgacccacgc gaaatcctcg acgtccaggc acgtattgtg atgagcgatg     9360

ccgaacgtac cgacgatgat ttatacgata cggtgattgg ctaccgtggc ggcaactgga     9420

tttatgagtg ggccccggat ctttgtgaag gaaccttact tctgtggtgt gacataattg     9480

gacaaactac ctacagagat ttaaagctct aaggtaaata taaaattttt aagtgtataa     9540

tgtgttaaac tactgattct aattgtttgt gtattttaga ttccaaccta tggaactgat     9600

gaatgggagc agtggtggaa tgcctttaat gaggaaaacc tgttttgctc agaagaaatg     9660

ccatctagtg atgatgaggc tactgctgac tctcaacatt ctactcctcc aaaaaagaag     9720

agaaaggtag aagaccccaa ggactttcct tcagaattgc taagtttttt gagtcatgct     9780

gtgtttagta atagaactct tgcttgcttt gctatttaca ccacaaagga aaaagctgca     9840

ctgctataca agaaaattat ggaaaaatat tctgtaacct ttataagtag gcataacagt     9900

tataatcata acatactgtt ttttcttact ccacacaggc atagagtgtc tgctattaat     9960

aactatgctc aaaaattgtg tacctttagc tttttaattt gtaaaggggt taataaggaa    10020

tatttgatgt atagtgcctt gactagagat cataatcagc cataccacat ttgtagaggt    10080

tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc    10140

aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat    10200

cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact    10260

catcaatgta tcttatcatg tctggatcaa ctggataact caagctaacc aaaatcatcc    10320

caaacttccc accccatacc ctattaccac tgccaattac ctagtggttt catttactct    10380

aaacctgtga ttcctctgaa ttattttcat tttaaagaaa ttgtatttgt taaatatgta    10440

ctacaaactt agtag                                                     10455


<210>  66
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  66

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Arg Ser Gly Ser Gly Asn 
1               5                   10                  15      


Phe Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly Asn Asp Asn Phe Gly 
            20                  25                  30          


Arg Gly Gly Asn Phe Ser Gly Arg Gly Gly Phe Gly Gly Ser Arg Gly 
        35                  40                  45              


Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr Asn Gly Phe Gly Asn 
    50                  55                  60                  


Asp Gly Ser Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn 
65                  70                  75                  80  


Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe 
                85                  90                  95      


Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala 
            100                 105                 110         


Lys Pro Arg Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Tyr Gly Ser Gly Arg Arg Phe Pro Gly Ile Leu Pro Pro Lys Lys Lys 
    130                 135                 140                 


Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn 
145                 150                 155                 160 


Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met 
                165                 170                 175     


Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu 
            180                 185                 190         


Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu 
        195                 200                 205             


Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Cys Arg Val Ile 
    210                 215                 220                 


Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala 
225                 230                 235                 240 


Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly 
                245                 250                 255     


Cys Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln 
            260                 265                 270         


Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys 
        275                 280                 285             


Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln 
    290                 295                 300                 


Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe 
305                 310                 315                 320 


Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu 
                325                 330                 335     


Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His 
            340                 345                 350         


Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile 
        355                 360                 365             


Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val 
    370                 375                 380                 


Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala 
385                 390                 395                 400 


Asn Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg 
                405                 410                 415     


Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser 
            420                 425                 430         


Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Glu 
        435                 440                 445             


Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His 
    450                 455                 460                 


Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys 
465                 470                 475                 480 


His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr 
                485                 490 


<210>  67
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  67

Met Asp Tyr Lys Asp Asp Asp Asp Lys Ser Arg Arg Arg Arg Ser Arg 
1               5                   10                  15      


Ser Arg Ser Arg Ser His Ser Arg Ser Arg Gly Arg Arg Tyr Ser Arg 
            20                  25                  30          


Ser Arg Ser Arg Ser Arg Gly Arg Arg Ser Arg Ser Ala Ser Pro Arg 
        35                  40                  45              


Arg Ser Arg Ser Ile Ser Leu Arg Arg Ser Arg Ser Ala Ser Leu Arg 
    50                  55                  60                  


Arg Ser Arg Ser Gly Ser Ile Lys Gly Ser Arg Tyr Phe Gln Ser Pro 
65                  70                  75                  80  


Ser Arg Ser Arg Ser Arg Ser Arg Ser Ile Ser Arg Pro Arg Ser Ser 
                85                  90                  95      


Arg Ser Lys Ser Arg Ser Pro Ser Pro Lys Arg Ser Arg Ser Pro Ser 
            100                 105                 110         


Gly Ser Pro Arg Arg Ser Ala Ser Pro Glu Arg Met Asp Pro Gly Ile 
        115                 120                 125             


Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu 
    130                 135                 140                 


Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu 
145                 150                 155                 160 


Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg 
                165                 170                 175     


Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu 
            180                 185                 190         


Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val 
        195                 200                 205             


Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu 
    210                 215                 220                 


Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu 
225                 230                 235                 240 


Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe 
                245                 250                 255     


Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His 
            260                 265                 270         


Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys 
        275                 280                 285             


Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala 
    290                 295                 300                 


Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg 
305                 310                 315                 320 


Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro 
                325                 330                 335     


Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln 
            340                 345                 350         


Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu 
        355                 360                 365             


Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu 
    370                 375                 380                 


Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His 
385                 390                 395                 400 


Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met 
                405                 410                 415     


Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr 
            420                 425                 430         


Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln 
        435                 440                 445             


Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg 
    450                 455                 460                 


Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr 
465                 470                 475                 480 


<210>  68
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  68

Met Asp Tyr Lys Asp Asp Asp Asp Lys Arg Arg Ser Arg Ser Pro Arg 
1               5                   10                  15      


Arg Arg Arg Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg 
            20                  25                  30          


Ser Arg Ser Arg Tyr Ser Arg Ser Lys Ser Arg Ser Arg Thr Arg Ser 
        35                  40                  45              


Arg Ser Arg Ser Thr Ser Lys Ser Arg Ser Ala Arg Arg Ser Lys Ser 
    50                  55                  60                  


Lys Ser Ser Ser Val Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser 
65                  70                  75                  80  


Arg Ser Arg Ser Pro Pro Pro Val Ser Lys Arg Glu Ser Lys Ser Arg 
                85                  90                  95      


Ser Arg Ser Lys Ser Pro Pro Lys Ser Pro Glu Glu Glu Gly Ala Val 
            100                 105                 110         


Ser Ser Pro Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg 
        115                 120                 125             


Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
    130                 135                 140                 


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
145                 150                 155                 160 


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
                165                 170                 175     


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
            180                 185                 190         


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
        195                 200                 205             


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
    210                 215                 220                 


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
225                 230                 235                 240 


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
                245                 250                 255     


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
            260                 265                 270         


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
        275                 280                 285             


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
    290                 295                 300                 


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
305                 310                 315                 320 


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
                325                 330                 335     


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
            340                 345                 350         


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
        355                 360                 365             


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
    370                 375                 380                 


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
385                 390                 395                 400 


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
                405                 410                 415     


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
            420                 425                 430         


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
        435                 440                 445             


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
    450                 455                 460                 


Leu Glu Lys Tyr Tyr 
465                 


<210>  69
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  69

Met Asp Tyr Lys Asp Asp Asp Asp Lys Ser Lys Arg His Ser Arg Ser 
1               5                   10                  15      


Arg Ser Arg Ser Arg Ser Arg Thr Arg Ser Ser Ser Arg Ser Arg Ser 
            20                  25                  30          


Arg Ser Arg Ser Arg Ser Arg Lys Ser Tyr Ser Arg Ser Arg Ser Arg 
        35                  40                  45              


Ser Arg Ser Arg Ser Arg Ser Lys Ser Arg Ser Val Ser Arg Ser Pro 
    50                  55                  60                  


Val Pro Glu Lys Ser Gln Lys Arg Gly Ser Ser Ser Arg Ser Lys Ser 
65                  70                  75                  80  


Pro Ala Ser Val Asp Arg Gln Arg Ser Arg Ser Arg Ser Arg Ser Arg 
                85                  90                  95      


Ser Val Asp Ser Gly Asn Pro Gly Ile Leu Pro Pro Lys Lys Lys Arg 
            100                 105                 110         


Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn 
        115                 120                 125             


Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu 
    130                 135                 140                 


Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu 
145                 150                 155                 160 


Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln 
                165                 170                 175     


Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln 
            180                 185                 190         


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
        195                 200                 205             


Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser 
    210                 215                 220                 


Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn 
225                 230                 235                 240 


Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp 
                245                 250                 255     


Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro 
            260                 265                 270         


Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala 
        275                 280                 285             


Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu 
    290                 295                 300                 


His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln 
305                 310                 315                 320 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln 
                325                 330                 335     


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
            340                 345                 350         


Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser 
        355                 360                 365             


Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala 
    370                 375                 380                 


Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala 
385                 390                 395                 400 


Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys 
                405                 410                 415     


Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys 
            420                 425                 430         


Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His 
        435                 440                 445             


Ile Leu Ala Lys Leu Glu Lys Tyr Tyr 
    450                 455         


<210>  70
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  70

Met Asp Tyr Lys Asp Asp Asp Asp Lys Arg Ser Arg Ser Arg Ser Arg 
1               5                   10                  15      


Ser Arg Ser Arg Ser Pro Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys 
            20                  25                  30          


Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg 
        35                  40                  45              


Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe 
    50                  55                  60                  


Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg 
65                  70                  75                  80  


Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala 
                85                  90                  95      


Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys 
            100                 105                 110         


Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg 
        115                 120                 125             


Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg 
    130                 135                 140                 


Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu 
145                 150                 155                 160 


Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln 
                165                 170                 175     


Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln 
            180                 185                 190         


Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu 
        195                 200                 205             


Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His 
    210                 215                 220                 


Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His 
225                 230                 235                 240 


Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His 
                245                 250                 255     


Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu 
            260                 265                 270         


Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn 
        275                 280                 285             


Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val 
    290                 295                 300                 


Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu 
305                 310                 315                 320 


Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met 
                325                 330                 335     


Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile 
            340                 345                 350         


Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile 
        355                 360                 365             


Leu Ala Lys Leu Glu Lys Tyr Tyr 
    370                 375     


<210>  71
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  71

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Arg Ser Gly Ser Gly Asn 
1               5                   10                  15      


Phe Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly Asn Asp Asn Phe Gly 
            20                  25                  30          


Arg Gly Gly Asn Phe Ser Gly Arg Gly Gly Phe Gly Gly Ser Arg Gly 
        35                  40                  45              


Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr Asn Gly Phe Gly Asn 
    50                  55                  60                  


Asp Gly Ser Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn 
65                  70                  75                  80  


Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe 
                85                  90                  95      


Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala 
            100                 105                 110         


Lys Pro Arg Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Tyr Gly Ser Gly Arg Arg Phe Pro Gly Ile Leu Pro Pro Lys Lys Lys 
    130                 135                 140                 


Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn 
145                 150                 155                 160 


Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met 
                165                 170                 175     


Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu 
            180                 185                 190         


Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu 
        195                 200                 205             


Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile 
    210                 215                 220                 


Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala 
225                 230                 235                 240 


Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly 
                245                 250                 255     


Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln 
            260                 265                 270         


Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys 
        275                 280                 285             


Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln 
    290                 295                 300                 


Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe 
305                 310                 315                 320 


Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu 
                325                 330                 335     


Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His 
            340                 345                 350         


Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile 
        355                 360                 365             


Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val 
    370                 375                 380                 


Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg 
                405                 410                 415     


Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser 
            420                 425                 430         


Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln 
        435                 440                 445             


Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His 
    450                 455                 460                 


Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys 
465                 470                 475                 480 


His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr 
                485                 490 


<210>  72
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  72

Met Asp Tyr Lys Asp Asp Asp Asp Lys Arg Gly Gly Asn Phe Gly Phe 
1               5                   10                  15      


Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly Pro Gly Pro Gly Ser 
            20                  25                  30          


Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser Gly Arg Gly Phe Gly 
        35                  40                  45              


Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly Gly Gly Asn Phe Gly 
    50                  55                  60                  


Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly Tyr Gly Gly Gly Gly 
65                  70                  75                  80  


Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Tyr Asp Asn 
                85                  90                  95      


Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Asn Tyr Asn Asp Phe Gly Asn 
            100                 105                 110         


Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met Lys Ser Gly Asn Phe 
        115                 120                 125             


Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly Gly Gly Asn Tyr Gly 
    130                 135                 140                 


Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly Gly Arg Ser Arg Tyr 
145                 150                 155                 160 


Pro Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg 
                165                 170                 175     


Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln 
            180                 185                 190         


Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His 
        195                 200                 205             


Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu 
    210                 215                 220                 


Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met 
225                 230                 235                 240 


Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly 
                245                 250                 255     


Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val 
            260                 265                 270         


Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala 
        275                 280                 285             


Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu 
    290                 295                 300                 


Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val 
305                 310                 315                 320 


Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile 
                325                 330                 335     


Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr 
            340                 345                 350         


Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln 
        355                 360                 365             


Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val 
    370                 375                 380                 


Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly 
385                 390                 395                 400 


Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val 
                405                 410                 415     


Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys 
            420                 425                 430         


Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val 
        435                 440                 445             


Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys 
    450                 455                 460                 


Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu 
465                 470                 475                 480 


Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala 
                485                 490                 495     


Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu 
            500                 505                 510         


Lys Tyr Tyr 
        515 


<210>  73
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  73

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gln Arg Gly Arg Gly 
1               5                   10                  15      


Gly Gly Ser Gly Asn Phe Met Gly Arg Gly Gly Asn Phe Gly Gly Gly 
            20                  25                  30          


Gly Gly Asn Phe Gly Arg Gly Gly Asn Phe Gly Gly Arg Gly Gly Tyr 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Ser Arg Gly Ser Tyr Gly Gly Gly Asp Gly 
    50                  55                  60                  


Gly Tyr Asn Gly Phe Gly Gly Asp Gly Gly Asn Tyr Gly Gly Gly Pro 
65                  70                  75                  80  


Gly Tyr Ser Ser Arg Gly Gly Tyr Gly Gly Gly Gly Pro Gly Tyr Gly 
                85                  90                  95      


Asn Gln Gly Gly Gly Tyr Gly Gly Gly Gly Gly Tyr Asp Gly Tyr Asn 
            100                 105                 110         


Glu Gly Gly Asn Phe Gly Gly Gly Asn Tyr Gly Gly Gly Gly Asn Tyr 
        115                 120                 125             


Asn Asp Phe Gly Asn Tyr Ser Gly Gln Gln Gln Ser Asn Tyr Gly Pro 
    130                 135                 140                 


Met Lys Gly Gly Ser Phe Gly Gly Arg Ser Ser Gly Ser Pro Tyr Gly 
145                 150                 155                 160 


Gly Gly Tyr Gly Ser Gly Gly Gly Ser Gly Gly Tyr Gly Ser Arg Arg 
                165                 170                 175     


Phe Pro Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly 
            180                 185                 190         


Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu 
        195                 200                 205             


Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln 
    210                 215                 220                 


His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala 
225                 230                 235                 240 


Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu 
                245                 250                 255     


Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe 
            260                 265                 270         


Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His 
        275                 280                 285             


Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys 
    290                 295                 300                 


Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu 
305                 310                 315                 320 


Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His 
                325                 330                 335     


Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe 
            340                 345                 350         


Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro 
        355                 360                 365             


Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp 
    370                 375                 380                 


Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu 
385                 390                 395                 400 


Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His 
                405                 410                 415     


Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn 
            420                 425                 430         


Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys 
        435                 440                 445             


Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu 
    450                 455                 460                 


Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met 
465                 470                 475                 480 


Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala 
                485                 490                 495     


Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile 
            500                 505                 510         


Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu 
        515                 520                 525             


Glu Lys Tyr Tyr 
    530         


<210>  74
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  74

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Tyr Gly Gly Gly Gly Pro 
1               5                   10                  15      


Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Pro Gly Ile Leu 
            20                  25                  30          


Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu 
        35                  40                  45              


Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile 
    50                  55                  60                  


Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe 
65                  70                  75                  80  


Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val 
                85                  90                  95      


Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe 
            100                 105                 110         


Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln 
        115                 120                 125             


Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala 
    130                 135                 140                 


Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile 
145                 150                 155                 160 


Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val 
                165                 170                 175     


Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys 
            180                 185                 190         


Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe 
        195                 200                 205             


Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val 
    210                 215                 220                 


Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile 
225                 230                 235                 240 


Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr 
                245                 250                 255     


Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp 
            260                 265                 270         


Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser 
        275                 280                 285             


Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala 
    290                 295                 300                 


Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn 
305                 310                 315                 320 


Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala 
                325                 330                 335     


Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg 
            340                 345                 350         


Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys 
        355                 360                 365             


Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr 
    370                 375                 380             


<210>  75
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  75

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Arg Ser Gly Ser Gly Asn 
1               5                   10                  15      


Phe Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly Asn Asp Asn Phe Gly 
            20                  25                  30          


Arg Gly Gly Asn Phe Ser Gly Arg Gly Gly Phe Gly Gly Ser Arg Gly 
        35                  40                  45              


Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr Asn Gly Phe Gly Asn 
    50                  55                  60                  


Asp Gly Ser Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn 
65                  70                  75                  80  


Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe 
                85                  90                  95      


Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala 
            100                 105                 110         


Lys Pro Arg Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Tyr Gly Ser Gly Arg Arg Phe Pro Gly Ile Leu Pro Pro Lys Lys Lys 
    130                 135                 140                 


Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn 
145                 150                 155                 160 


Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met 
                165                 170                 175     


Glu Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu 
            180                 185                 190         


Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu 
        195                 200                 205             


Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile 
    210                 215                 220                 


Glu Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala 
225                 230                 235                 240 


Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly 
                245                 250                 255     


Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln 
            260                 265                 270         


Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys 
        275                 280                 285             


Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln 
    290                 295                 300                 


Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe 
305                 310                 315                 320 


Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu 
                325                 330                 335     


Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His 
            340                 345                 350         


Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile 
        355                 360                 365             


Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val 
    370                 375                 380                 


Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala 
385                 390                 395                 400 


Cys Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg 
                405                 410                 415     


Ala Val Leu Ile Asp Glu Cys Val Thr Met Asn Asp Gly Pro His Ser 
            420                 425                 430         


Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Glu 
        435                 440                 445             


Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His 
    450                 455                 460                 


Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys 
465                 470                 475                 480 


His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr 
                485                 490 


<210>  76
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein

<400>  76

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Arg Ser Gly Ser Gly Asn 
1               5                   10                  15      


Phe Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly Asn Asp Asn Phe Gly 
            20                  25                  30          


Arg Gly Gly Asn Phe Ser Gly Arg Gly Gly Phe Gly Gly Ser Arg Gly 
        35                  40                  45              


Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr Asn Gly Phe Gly Asn 
    50                  55                  60                  


Asp Gly Ser Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn 
65                  70                  75                  80  


Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe 
                85                  90                  95      


Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala 
            100                 105                 110         


Lys Pro Arg Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Tyr Gly Ser Gly Arg Arg Phe Pro Gly Ile Leu Pro Pro Lys Lys Lys 
    130                 135                 140                 


Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn 
145                 150                 155                 160 


Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met 
                165                 170                 175     


Glu Phe Ser Gln Asp Gln His Gly Cys Arg Phe Ile Gln Leu Lys Leu 
            180                 185                 190         


Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu 
        195                 200                 205             


Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile 
    210                 215                 220                 


Glu Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala 
225                 230                 235                 240 


Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly 
                245                 250                 255     


Asn Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln 
            260                 265                 270         


Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys 
        275                 280                 285             


Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln 
    290                 295                 300                 


Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe 
305                 310                 315                 320 


Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu 
                325                 330                 335     


Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His 
            340                 345                 350         


Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile 
        355                 360                 365             


Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val 
    370                 375                 380                 


Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala 
385                 390                 395                 400 


Cys Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg 
                405                 410                 415     


Ala Val Leu Ile Asp Glu Cys Val Thr Met Asn Asp Gly Pro His Ser 
            420                 425                 430         


Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Cys Tyr Val Val Gln 
        435                 440                 445             


Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His 
    450                 455                 460                 


Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys 
465                 470                 475                 480 


His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr 
                485                 490 


