                         SEQUENCE LISTING

<110>  Novo Nordisk
       Novo Nordisk A/S
 
<120>  Antibodies

<130>  7788

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  1

Asp Ser Glu Glu Asp Glu Glu His Thr Ile Ile Thr Asp Thr Glu Leu 
1               5                   10                  15      


Pro Pro Leu Lys Leu Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp 
            20                  25                  30          


Gly Pro Cys Lys Ala Ile Met Lys Arg Phe Phe Phe Asn Ile Phe Thr 
        35                  40                  45              


Arg Gln Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gln Asn 
    50                  55                  60                  


Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp Asn 
65                  70                  75                  80  


Ala Asn Arg Ile Ile Lys Thr Thr Leu Gln Gln Glu Lys Pro Asp Phe 
                85                  90                  95      


Cys Phe Leu Glu Glu Asp Pro Gly Ile Cys Arg Gly Tyr Ile Thr Arg 
            100                 105                 110         


Tyr Phe Tyr Asn Asn Gln Thr Lys Gln Cys Glu Arg Phe Lys Tyr Gly 
        115                 120                 125             


Gly Cys Leu Gly Asn Met Asn Asn Phe Glu Thr Leu Glu Glu Cys Lys 
    130                 135                 140                 


Asn Ile Cys Glu Asp Gly Pro Asn Gly Phe Gln Val Asp Asn Tyr Gly 
145                 150                 155                 160 


Thr Gln Leu Asn Ala Val Asn Asn Ser Leu Thr Pro Gln Ser Thr Lys 
                165                 170                 175     


Val Pro Ser Leu Phe Glu Phe His Gly Pro Ser Trp Cys Leu Thr Pro 
            180                 185                 190         


Ala Asp Arg Gly Leu Cys Arg Ala Asn Glu Asn Arg Phe Tyr Tyr Asn 
        195                 200                 205             


Ser Val Ile Gly Lys Cys Arg Pro Phe Lys Tyr Ser Gly Cys Gly Gly 
    210                 215                 220                 


Asn Glu Asn Asn Phe Thr Ser Lys Gln Glu Cys Leu Arg Ala Cys Lys 
225                 230                 235                 240 


Lys Gly Phe Ile Gln Arg Ile Ser Lys Gly Gly Leu Ile Lys Thr Lys 
                245                 250                 255     


Arg Lys Arg Lys Lys Gln Arg Val Lys Ile Ala Tyr Glu Glu Ile Phe 
            260                 265                 270         


Val Lys Asn Met 
        275     


<210>  2
<211>  66
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial construct used for epitope mapping

<400>  2

Gln Glu Lys Pro Asp Phe Cys Phe Leu Glu Glu Asp Pro Gly Ile Cys 
1               5                   10                  15      


Arg Gly Tyr Ile Thr Arg Tyr Phe Tyr Asn Asn Gln Thr Lys Gln Cys 
            20                  25                  30          


Glu Arg Phe Lys Tyr Gly Gly Cys Leu Gly Asn Met Asn Asn Phe Glu 
        35                  40                  45              


Thr Leu Glu Glu Cys Lys Asn Ile Cys Glu Asp Gly His His His His 
    50                  55                  60                  


His His 
65      


<210>  3
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  3
gatattgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcttcc       60

atctcttgca agtcaagtca gagcctctta gaaagtgatg gaaaaaccta tttaaattgg      120

ttattacaga ggccaggcga gtctccaaag ctcctaatct atctggtgtc tatactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac gctgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgtt tgcaagctac acattttcct      300

cagacgttcg gtggcggcac caagctggaa atcaaacgg                             339


<210>  4
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  4

Asp Ile Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Glu Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Ile Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Ala 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  5
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  5
ccgtttgatt tccagcttgg tgccgccacc gaacgtctga ggaaaatgtg tagcttgcaa       60

acaataataa actcccaaat cctcagcctc cactctgctg attttcagcg tgaaatctgt      120

ccctgatcca ctgccagtga acctgtcagg gactccagag tccagtatag acaccagata      180

gattaggagc tttggagact cgcctggcct ctgtaataac caatttaaat aggtttttcc      240

atcactttct aagaggctct gacttgactt gcaagagatg gaagctggtt gtccaatggt      300

aaccgacaaa gtgagtggag tctgggtcat cacaatatc                             339


<210>  6
<211>  219
<212>  PRT
<213>  Mus musculus

<400>  6

Asp Ile Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Glu Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Ile Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Ala 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  7
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  7
gaggtggagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt aactatgcca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtcgta gtggtagtta ctcctacttt      180

ccagacagtg tgcagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgcg gtctgaggac acggccatgt attattgtac aagacttggg      300

ggttacgacg agggggatgc tatggactcc tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  8
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  8

Glu Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Ser Tyr Ser Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Gly Gly Tyr Asp Glu Gly Asp Ala Met Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  9
tgaggagacg gtgactgagg ttccttgacc ccaggagtcc atagcatccc cctcgtcgta       60

acccccaagt cttgtacaat aatacatggc cgtgtcctca gaccgcagac tgctcatttg      120

caggtacagg gtgttcttgg cattgtctct ggagatggtg aatcgaccct gcacactgtc      180

tggaaagtag gagtaactac cactacgact aatggttgcg acccactcca gcctcttctc      240

cggagtctgg cgaacccaag acatggcata gttactgaaa gtgaatccag aggctgcaca      300

ggagagtttc agggaccctc caggcttcac taagcctccc ccagactcca ccagctccac      360

ctc                                                                    363


<210>  10
<211>  445
<212>  PRT
<213>  Mus musculus

<400>  10

Glu Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Ser Tyr Ser Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Gly Gly Tyr Asp Glu Gly Asp Ala Met Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
    210                 215                 220                 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
    290                 295                 300                 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
305                 310                 315                 320 


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
            340                 345                 350         


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
        355                 360                 365             


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
    370                 375                 380                 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
385                 390                 395                 400 


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
                405                 410                 415     


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
            420                 425                 430         


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445 


<210>  11
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  11
cccttgacca ggcatcccag                                                   20


<210>  12
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  12
gctctagact aacactcatt cctgttgaag ctcttg                                 36


<210>  13
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized variable light chain

<400>  13
gacatcgtga tgacccagac ccctctgtcc ctgtccgtga cccctggcca gcctgcctcc       60

atctcctgca agtcctccca gtccctgctg gaatccgacg gcaagaccta cctgaactgg      120

tatctgcaga agcctggcca gtcccctcag ctgctgatct acctggtgtc catcctggac      180

tccggcgtgc ctgaccggtt ctccggctcc ggcagcggca ccgacttcac cctgaagatc      240

tcccgggtgg aggccgagga cgtgggcgtg tactactgcc tgcaggccac ccacttccct      300

cagacctttg gcggcggaac aaaggtggag atcaagcgt                             339


<210>  14
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized variable light chain

<400>  14
ctgtagcact actgggtctg gggagacagg gacaggcact ggggaccggt cggacggagg       60

tagaggacgt tcaggagggt cagggacgac cttaggctgc cgttctggat ggacttgacc      120

atagacgtct tcggaccggt caggggagtc gacgactaga tggaccacag gtaggacctg      180

aggccgcacg gactggccaa gaggccgagg ccgtcgccgt ggctgaagtg ggacttctag      240

agggcccacc tccggctcct gcacccgcac atgatgacgg acgtccggtg ggtgaaggga      300

gtctggaaac cgccgccttg tttccacctc tagttcgca                             339


<210>  15
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized variable light chain

<400>  15

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Ile Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ala 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  16
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized variable heavy chain

<400>  16
gaggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcggctc cctgcggctg       60

tcctgcgctg cctccggctt caccttctcc aactacgcca tgtcctgggt gcggcagacc      120

ccagaaaagc ggctggaatg ggtggccacc atctcccggt ccggctccta ctcctacttc      180

cctgactccg tgcagggccg gttcaccatc agcagggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgag agccgaggac acagccgtgt actactgcgc caggctgggc      300

ggctacgacg agggcgacgc catggacagc tggggccagg gcaccaccgt gaccgtgtcc      360

tcc                                                                    363


<210>  17
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized variable heavy chain

<400>  17
ctccacgtcg accagctcag accgccgcct gaccacttcg gaccgccgag ggacgccgac       60

aggacgcgac ggaggccgaa gtggaagagg ttgatgcggt acaggaccca cgccgtctgg      120

ggtcttttcg ccgaccttac ccaccggtgg tagagggcca ggccgaggat gaggatgaag      180

ggactgaggc acgtcccggc caagtggtag tcgtccctgt tgcggttctt gagggacatg      240

gacgtctact tgagggactc tcggctcctg tgtcggcaca tgatgacgcg gtccgacccg      300

ccgatgctgc tcccgctgcg gtacctgtcg accccggtcc cgtggtggca ctggcacagg      360

agg                                                                    363


<210>  18
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized variable heavy chain

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Ser Tyr Ser Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Tyr Asp Glu Gly Asp Ala Met Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized constant light chain

<400>  19
gacatcgtga tgacccagac ccctctgtcc ctgtccgtga cccctggcca gcctgcctcc       60

atctcctgca agtcctccca gtccctgctg gaatccgacg gcaagaccta cctgaactgg      120

tatctgcaga agcctggcca gtcccctcag ctgctgatct acctggtgtc catcctggac      180

tccggcgtgc ctgaccggtt ctccggctcc ggcagcggca ccgacttcac cctgaagatc      240

tcccgggtgg aggccgagga cgtgggcgtg tactactgcc tgcaggccac ccacttccct      300

cagacctttg gcggcggaac aaaggtggag atcaagcgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  20
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized constant light chain

<400>  20
ctgtagcact actgggtctg gggagacagg gacaggcact ggggaccggt cggacggagg       60

tagaggacgt tcaggagggt cagggacgac cttaggctgc cgttctggat ggacttgacc      120

atagacgtct tcggaccggt caggggagtc gacgactaga tggaccacag gtaggacctg      180

aggccgcacg gactggccaa gaggccgagg ccgtcgccgt ggctgaagtg ggacttctag      240

agggcccacc tccggctcct gcacccgcac atgatgacgg acgtccggtg ggtgaaggga      300

gtctggaaac cgccgccttg tttccacctc tagttcgcat gccaccgacg tggtagacag      360

aagtagaagg gcggtagact actcgtcaac tttagacctt gacggagaca acacacggac      420

gacttattga agatagggtc tctccggttt catgtcacct tccacctatt gcgggaggtt      480

agcccattga gggtcctctc acagtgtctc gtcctgtcgt tcctgtcgtg gatgtcggag      540

tcgtcgtggg actgcgactc gtttcgtctg atgctctttg tgtttcagat gcggacgctt      600

cagtgggtag tcccggactc gagcgggcag tgtttctcga agttgtcccc tctcaca         657


<210>  21
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized constant light chain

<400>  21

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Ile Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ala 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  22
<211>  1344
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized constant heavy chain

<400>  22
gaggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcggctc cctgcggctg       60

tcctgcgctg cctccggctt caccttctcc aactacgcca tgtcctgggt gcggcagacc      120

ccagaaaagc ggctggaatg ggtggccacc atctcccggt ccggctccta ctcctacttc      180

cctgactccg tgcagggccg gttcaccatc agcagggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgag agccgaggac acagccgtgt actactgcgc caggctgggc      300

ggctacgacg agggcgacgc catggacagc tggggccagg gcaccaccgt gaccgtgtcc      360

tccgctagca ccaagggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      660

tccaaatatg gtcccccatg cccaccatgc ccagcacctg agttcctggg gggaccatca      720

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      780

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      840

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac      960

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag     1260

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1320

agcctctccc tgtctctggg taaa                                            1344


<210>  23
<211>  1344
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized constant heavy chain

<400>  23
ctccacgtcg accagctcag accgccgcct gaccacttcg gaccgccgag ggacgccgac       60

aggacgcgac ggaggccgaa gtggaagagg ttgatgcggt acaggaccca cgccgtctgg      120

ggtcttttcg ccgaccttac ccaccggtgg tagagggcca ggccgaggat gaggatgaag      180

ggactgaggc acgtcccggc caagtggtag tcgtccctgt tgcggttctt gagggacatg      240

gacgtctact tgagggactc tcggctcctg tgtcggcaca tgatgacgcg gtccgacccg      300

ccgatgctgc tcccgctgcg gtacctgtcg accccggtcc cgtggtggca ctggcacagg      360

aggcgatcgt ggttcccggg taggcagaag ggggaccgcg ggacgaggtc ctcgtggagg      420

ctctcgtgtc ggcgggaccc gacggaccag ttcctgatga aggggcttgg ccactgccac      480

agcaccttga gtccgcggga ctggtcgccg cacgtgtgga agggccgaca ggatgtcagg      540

agtcctgaga tgagggagtc gtcgcaccac tggcacggga ggtcgtcgaa cccgtgcttc      600

tggatgtgga cgttgcatct agtgttcggg tcgttgtggt tccacctgtt ctctcaactc      660

aggtttatac cagggggtac gggtggtacg ggtcgtggac tcaaggaccc ccctggtagt      720

cagaaggaca aggggggttt tgggttcctg tgagagtact agagggcctg gggactccag      780

tgcacgcacc accacctgca ctcggtcctt ctggggctcc aggtcaagtt gaccatgcac      840

ctaccgcacc tccacgtatt acggttctgt ttcggcgccc tcctcgtcaa gttgtcgtgc      900

atggcacacc agtcgcagga gtggcaggac gtggtcctga ccgacttgcc gttcctcatg      960

ttcacgttcc agaggttgtt tccggagggc aggaggtagc tcttttggta gaggtttcgg     1020

tttcccgtcg gggctctcgg tgtccacatg tgggacgggg gtagggtcct cctctactgg     1080

ttcttggtcc agtcggactg gacggaccag tttccgaaga tggggtcgct gtagcggcac     1140

ctcaccctct cgttacccgt cggcctcttg ttgatgttct ggtgcggagg gcacgacctg     1200

aggctgccga ggaagaagga gatgtcgtcc gattggcacc tgttctcgtc caccgtcctc     1260

cccttacaga agagtacgag gcactacgta ctccgagacg tgttggtgat gtgtgtcttc     1320

tcggagaggg acagagaccc attt                                            1344


<210>  24
<211>  448
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized constant heavy chain

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Ser Tyr Ser Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Tyr Asp Glu Gly Asp Ala Met Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210>  25
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  HzTFPI4F36-CDRgrafted VL nucleic acid sequence (signal peptide 
       sequence omitted)

<400>  25
gacatcgtga tgacccagac ccctctgtcc ctgtccgtga cccctggcca gcctgcctcc       60

atctcctgca agtcctccca gtccctgctg gaatccgacg gcaagaccta cctgaactgg      120

tatctgcaga agcctggcca gtcccctcag ctgctgatct acctggtgtc catcctggac      180

tccggcgtgc ctgaccggtt ctccggctcc ggcagcggca ccgacttcac cctgaagatc      240

tcccgggtgg aggccgagga cgtgggcgtg tactactgcc tgcaggccac ccacttccct      300

cagacctttg gcggcggaac aaaggtggag atcaagcgt                             339


<210>  26
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  HzTFPI4F36-CDRgrafted VL amino acid sequence (signal peptide 
       sequence omitted)

<400>  26

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Ile Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ala 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  27
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  HzTFPI4F36-CDRgrafted VH nucleic acid sequence (signal peptide 
       sequence omitted)

<400>  27
gaggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcggctc cctgcggctg       60

tcctgcgctg cctccggctt caccttctcc aactacgcca tgtcctgggt gcggcaggcc      120

ccagggaagg gactggaatg ggtgtccacc atctcccggt ccggctccta ctcctactac      180

gccgactccg tgaagggccg gttcaccatc agcagggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgag agccgaggac acagccgtgt actactgcgc caggctgggc      300

ggctacgacg agggcgacgc catggacagc tggggccagg gcaccaccgt gaccgtgtcc      360

tcc                                                                    363


<210>  28
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  HzTFPI4F36-CDRgrafted VH amino acid sequence (signal peptide 
       sequence omitted)

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Arg Ser Gly Ser Tyr Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Tyr Asp Glu Gly Asp Ala Met Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  29
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  HzTFPI4F36-CDRgrafted LC amino acid sequence, human kappa chain 
       (signal peptide sequence omitted)

<400>  29

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Ile Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ala 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  30
<211>  448
<212>  PRT
<213>  Artificial

<220>
<223>  HzTFPI4F36-CDRgrafted HC amino acid sequence, human IgG4(S241P) 
       (signal peptide sequence omitted)

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Arg Ser Gly Ser Tyr Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Tyr Asp Glu Gly Asp Ala Met Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210>  31
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  31

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ile His Leu Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  32
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


<210>  33
<211>  224
<212>  PRT
<213>  Mus musculus

<400>  33

Glu Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Ser Tyr Ser Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Gly Gly Tyr Asp Glu Gly Asp Ala Met Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
    210                 215                 220                 


<210>  34
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Ser Tyr Ser Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Tyr Asp Glu Gly Asp Ala Met Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220         


