                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  Antibodies

<130>  7925

<140>
<141>

<160>  9    

<170>  PatentIn version 3.4

<210>  1
<211>  276
<212>  PRT
<213>  Homo sapiens

<220>
<221>  DOMAIN
<222>  (26)..(76)
<223>  Kunitz domain 1

<220>
<221>  DOMAIN
<222>  (97)..(147)
<223>  Kunitz domain 2

<220>
<221>  DOMAIN
<222>  (188)..(238)
<223>  Kunitz domain 3

<400>  1
Asp Ser Glu Glu Asp Glu Glu His Thr Ile Ile Thr Asp Thr Glu Leu 
1               5                   10                  15      

Pro Pro Leu Lys Leu Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp 
            20                  25                  30          

Gly Pro Cys Lys Ala Ile Met Lys Arg Phe Phe Phe Asn Ile Phe Thr 
        35                  40                  45              

Arg Gln Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gln Asn 
    50                  55                  60                  

Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp Asn 
65                  70                  75                  80  

Ala Asn Arg Ile Ile Lys Thr Thr Leu Gln Gln Glu Lys Pro Asp Phe 
                85                  90                  95      

Cys Phe Leu Glu Glu Asp Pro Gly Ile Cys Arg Gly Tyr Ile Thr Arg 
            100                 105                 110         

Tyr Phe Tyr Asn Asn Gln Thr Lys Gln Cys Glu Arg Phe Lys Tyr Gly 
        115                 120                 125             

Gly Cys Leu Gly Asn Met Asn Asn Phe Glu Thr Leu Glu Glu Cys Lys 
    130                 135                 140                 

Asn Ile Cys Glu Asp Gly Pro Asn Gly Phe Gln Val Asp Asn Tyr Gly 
145                 150                 155                 160 

Thr Gln Leu Asn Ala Val Asn Asn Ser Leu Thr Pro Gln Ser Thr Lys 
                165                 170                 175     

Val Pro Ser Leu Phe Glu Phe His Gly Pro Ser Trp Cys Leu Thr Pro 
            180                 185                 190         

Ala Asp Arg Gly Leu Cys Arg Ala Asn Glu Asn Arg Phe Tyr Tyr Asn 
        195                 200                 205             

Ser Val Ile Gly Lys Cys Arg Pro Phe Lys Tyr Ser Gly Cys Gly Gly 
    210                 215                 220                 

Asn Glu Asn Asn Phe Thr Ser Lys Gln Glu Cys Leu Arg Ala Cys Lys 
225                 230                 235                 240 

Lys Gly Phe Ile Gln Arg Ile Ser Lys Gly Gly Leu Ile Lys Thr Lys 
                245                 250                 255     

Arg Lys Arg Lys Lys Gln Arg Val Lys Ile Ala Tyr Glu Glu Ile Phe 
            260                 265                 270         

Val Lys Asn Met 
        275     


<210>  2
<211>  339
<212>  DNA
<213>  Mus musculus

<220>
<221>  CDS
<222>  (1)..(339)

<400>  2
gat gtt gtg atg acc cag act cca ctc act ttg tcg gtt acc att gga       48
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly         
1               5                   10                  15              

caa cca gct tcc atc tct tgc aag tca agt cag agc ctc tta gat agt       96
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser         
            20                  25                  30                  

gat gga aaa acc tat tta aat tgg tta tta cag agg cca ggc gag tct      144
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Glu Ser         
        35                  40                  45                      

cca aag ctc ctt atc tat ctg gtg tct aaa ctg gac tct gga gtc cct      192
Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc act ggc agt gga tca ggg aca gat ttc aca ctg aaa atc      240
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat ttg gga gtt tat tac tgc tta caa ggt      288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly         
                85                  90                  95              

aca cat ttt cct cac acg ttc gga ggg ggg acc aag ctg gaa ata aaa      336
Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 

cgg                                                                  339
Arg                                                                     
                                                                        


<210>  3
<211>  113
<212>  PRT
<213>  Mus musculus

<220>
<221>  DOMAIN
<222>  (24)..(39)
<223>  CDR

<220>
<221>  DOMAIN
<222>  (55)..(61)
<223>  CDR

<220>
<221>  DOMAIN
<222>  (94)..(102)
<223>  CDR


<400>  3
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      

Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          

Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Glu Ser 
        35                  40                  45              

Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  

Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  

Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      

Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

Arg 
    


<210>  4
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  4
ccgttttatt tccagcttgg tcccccctcc gaacgtgtga ggaaaatgtg taccttgtaa     60
gcagtaataa actcccaaat cctcagcctc cactctgctg attttcagtg tgaaatctgt    120
ccctgatcca ctgccagtga acctgtcagg gactccagag tccagtttag acaccagata    180
gataaggagc tttggagact cgcctggcct ctgtaataac caatttaaat aggtttttcc    240
atcactatct aagaggctct gacttgactt gcaagagatg gaagctggtt gtccaatggt    300
aaccgacaaa gtgagtggag tctgggtcat cacaacatc                           339


<210>  5
<211>  354
<212>  DNA
<213>  Mus musculus

<220>
<221>  CDS
<222>  (1)..(354)

<400>  5
gaa gtg aag ctg gta gag tct ggg gga ggc ttg gtg aag cct gga ggg       48
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc act ttc agt aac tat       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr         
            20                  25                  30                  

gcc ctg tct tgg gtt cgc cag act cca gac aag agg ctg gag tgg gtc      144
Ala Leu Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val         
        35                  40                  45                      

gca tcc att agt agt ggt ggt gcc acc tac tat cca gac agt gtg gag      192
Ala Ser Ile Ser Ser Gly Gly Ala Thr Tyr Tyr Pro Asp Ser Val Glu         
    50                  55                  60                          

ggc cga ttc acc atc tcc aga gat aat gtc agg aac atc ctg tac ctg      240
Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg Asn Ile Leu Tyr Leu         
65                  70                  75                  80          

caa atg agc agt ctg cag tct gag gac acg gcc atg tat tac tgt aca      288
Gln Met Ser Ser Leu Gln Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr         
                85                  90                  95              

aga gga gcc tac ggc tcg gac tac ttt gac tac tgg ggc caa ggc acc      336
Arg Gly Ala Tyr Gly Ser Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr         
            100                 105                 110                 

act ctc aca gtc tcc tca                                              354
Thr Leu Thr Val Ser Ser                                                 
        115                                                             


<210>  6
<211>  118
<212>  PRT
<213>  Mus musculus

<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR

<220>
<221>  DOMAIN
<222>  (50)..(65)
<223>  CDR

<220>
<221>  DOMAIN
<222>  (98)..(107)
<223>  CDR

<400>  6
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          

Ala Leu Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              

Ala Ser Ile Ser Ser Gly Gly Ala Thr Tyr Tyr Pro Asp Ser Val Glu 
    50                  55                  60                  

Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  

Gln Met Ser Ser Leu Gln Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr 
                85                  90                  95      

Arg Gly Ala Tyr Gly Ser Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         

Thr Leu Thr Val Ser Ser 
        115             


<210>  7
<211>  354
<212>  DNA
<213>  Mus musculus

<400>  7
tgaggagact gtgagagtgg tgccttggcc ccagtagtca aagtagtccg agccgtaggc     60
tcctcttgta cagtaataca tggccgtgtc ctcagactgc agactgctca tttgcaggta    120
caggatgttc ctgacattat ctctggagat ggtgaatcgg ccctccacac tgtctggata    180
gtaggtggca ccaccactac taatggatgc gacccactcc agcctcttgt ctggagtctg    240
gcgaacccaa gacagggcat agttactgaa agtgaatcca gaggctgcac aggagagtct    300
cagggaccct ccaggcttca ccaagcctcc cccagactct accagcttca cttc          354


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  8
cccttgacca ggcatcccag                                                 20


<210>  9
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  9
gctctagact aacactcatt cctgttgaag ctcttg                               36

 