                         SEQUENCE LISTING

<110>  UNIVERSITE LAVAL
       CHAHINE, Mohamed
 
<120>  METHODS, REAGENTS AND KITS FOR THE IDENTIFICATION OF MODULATORS 
       OF VOLTAGE-GATED SODIUM CHANNELS

<130>  780/11229.297

<150>  US  61/139,790
<151>  2008-12-22

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  6051
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcaaact tcctattacc tcggggcacc agcagcttcc gcaggttcac acgggagtcc       60

ctggcagcca tcgagaagcg catggcagag aagcaagccc gcggctcaac caccttgcag      120

gagagccgag aggggctgcc cgaggaggag gctccccggc cccagctgga cctgcaggcc      180

tccaaaaagc tgccagatct ctatggcaat ccaccccaag agctcatcgg agagcccctg      240

gaggacctgg accccttcta tagcacccaa aagactttca tcgtactgaa taaaggcaag      300

accatcttcc ggttcagtgc caccaacgcc ttgtatgtcc tcagtccctt ccaccccatc      360

cggagagcgg ctgtgaagat tctggttcac tcgctcttca acatgctcat catgtgcacc      420

atcctcacca actgcgtgtt catggcccag cacgaccctc caccctggac caagtatgtc      480

gagtacacct tcaccgccat ttacaccttt gagtctctgg tcaagattct ggctcgaggc      540

ttctgcctgc acgcgttcac tttccttcgg gacccatgga actggctgga ctttagtgtg      600

attatcatgg catacacaac tgaatttgtg gacctgggca atgtctcagc cttacgcacc      660

ttccgagtcc tccgggccct gaaaactata tcagtcattt cagggctgaa gaccatcgtg      720

ggggccctga tccagtctgt gaagaagctg gctgatgtga tggtcctcac agtcttctgc      780

ctcagcgtct ttgccctcat cggcctgcag ctcttcatgg gcaacctaag gcacaagtgc      840

gtgcgcaact tcacagcgct caacggcacc aacggctccg tggaggccga cggcttggtc      900

tgggaatccc tggaccttta cctcagtgat ccagaaaatt acctgctcaa gaacggcacc      960

tctgatgtgt tactgtgtgg gaacagctct gacgctggga catgtccgga gggctaccgg     1020

tgcctaaagg caggcgagaa ccccgaccac ggctacacca gcttcgattc ctttgcctgg     1080

gcctttcttg cactcttccg cctgatgacg caggactgct gggagcgcct ctatcagcag     1140

accctcaggt ccgcagggaa gatctacatg atcttcttca tgcttgtcat cttcctgggg     1200

tccttctacc tggtgaacct gatcctggcc gtggtcgcaa tggcctatga ggagcaaaac     1260

caagccacca tcgctgagac cgaggagaag gaaaagcgct tccaggaggc catggaaatg     1320

ctcaagaaag aacacgaggc cctcaccatc aggggtgtgg ataccgtgtc ccgtagctcc     1380

ttggagatgt cccctttggc cccagtaaac agccatgaga gaagaagcaa gaggagaaaa     1440

cggatgtctt caggaactga ggagtgtggg gaggacaggc tccccaagtc tgactcagaa     1500

gatggtccca gagcaatgaa tcatctcagc ctcacccgtg gcctcagcag gacttctatg     1560

aagccacgtt ccagccgcgg gagcattttc acctttcgca ggcgagacct gggttctgaa     1620

gcagattttg cagatgatga aaacagcaca gcgggggaga gcgagagcca ccacacatca     1680

ctgctggtgc cctggcccct gcgccggacc agtgcccagg gacagcccag tcccggaacc     1740

tcggctcctg gccacgccct ccatggcaaa aagaacagca ctgtggactg caatggggtg     1800

gtctcattac tgggggcagg cgacccagag gccacatccc caggaagcca cctcctccgc     1860

cctgtgatgc tagagcaccc gccagacacg accacgccat cggaggagcc aggcgggccc     1920

cagatgctga cctcccaggc tccgtgtgta gatggcttcg aggagccagg agcacggcag     1980

cgggccctca gcgcagtcag cgtcctcacc agcgcactgg aagagttaga ggagtctcgc     2040

cacaagtgtc caccatgctg gaaccgtctc gcccagcgct acctgatctg ggagtgctgc     2100

ccgctgtgga tgtccatcaa gcagggagtg aagttggtgg tcatggaccc gtttactgac     2160

ctcaccatca ctatgtgcat cgtactcaac acactcttca tggcgctgga gcactacaac     2220

atgacaagtg aattcgagga gatgctgcag gtcggaaacc tggtcttcac agggattttc     2280

acagcagaga tgaccttcaa gatcattgcc ctcgacccct actactactt ccaacagggc     2340

tggaacatct tcgacagcat catcgtcatc cttagcctca tggagctggg cctgtcccgc     2400

atgagcaact tgtcggtgct gcgctccttc cgcctgctgc gggtcttcaa gctggccaaa     2460

tcatggccca ccctgaacac actcatcaag atcatcggga actcagtggg ggcactgggg     2520

aacctgacac tggtgctagc catcatcgtg ttcatctttg ctgtggtggg catgcagctc     2580

tttggcaaga actactcgga gctgagggac agcgactcag gcctgctgcc tcgctggcac     2640

atgatggact tctttcatgc cttcctcatc atcttccgca tcctctgtgg agagtggatc     2700

gagaccatgt gggactgcat ggaggtgtcg gggcagtcat tatgcctgct ggtcttcttg     2760

cttgttatgg tcattggcaa ccttgtggtc ctgaatctct tcctggcctt gctgctcagc     2820

tccttcagtg cagacaacct cacagcccct gatgaggaca gagagatgaa caacctccag     2880

ctggccctgg cccgcatcca gaggggcctg cgctttgtca agcggaccac ctgggatttc     2940

tgctgtggtc tcctgcggca gcggcctcag aagcccgcag cccttgccgc ccagggccag     3000

ctgcccagct gcattgccac cccctactcc ccgccacccc cagagacgga gaaggtgcct     3060

cccacccgca aggaaacacg gtttgaggaa ggcgagcaac caggccaggg cacccccggg     3120

gatccagagc ccgtgtgtgt gcccatcgct gtggccgagt cagacacaga tgaccaagaa     3180

gaagatgagg agaacagcct gggcacggag gaggagtcca gcaagcagca ggaatcccag     3240

cctgtgtccg gtggcccaga ggcccctccg gattccagga cctggagcca ggtgtcagcg     3300

actgcctcct ctgaggccga ggccagtgca tctcaggccg actggcggca gcagtggaaa     3360

gcggaacccc aggccccagg gtgcggtgag accccagagg acagttgctc cgagggcagc     3420

acagcagaca tgaccaacac cgctgagctc ctggagcaga tccctgacct cggccaggat     3480

gtcaaggacc cagaggactg cttcactgaa ggctgtgtcc ggcgctgtcc ctgctgtgcg     3540

gtggacacca cacaggcccc agggaaggtc tggtggcggt tgcgcaagac ctgctaccac     3600

atcgtggagc acagctggtt cgagacattc atcatcttca tgatcctact cagcagtgga     3660

gcgctggcct tcgaggacat ctacctagag gagcggaaga ccatcaaggt tctgcttgag     3720

tatgccgaca agatgttcac atatgtcttc gtgctggaga tgctgctcaa gtgggtggcc     3780

tacggcttca agaagtactt caccaatgcc tggtgctggc tcgacttcct catcgtagac     3840

gtctctctgg tcagcctggt ggccaacacc ctgggctttg ccgagatggg ccccatcaag     3900

tcactgcgga cgctgcgtgc actccgtcct ctgagagctc tgtcacgatt tgagggcatg     3960

agggtggtgg tcaatgccct ggtgggcgcc atcccgtcca tcatgaacgt cctcctcgtc     4020

tgcctcatct tctggctcat cttcagcatc atgggcgtga acctctttgc ggggaagttt     4080

gggaggtgca tcaaccagac agagggagac ttgcctttga actacaccat cgtgaacaac     4140

aagagccagt gtgagtcctt gaacttgacc ggagaattgt actggaccaa ggtgaaagtc     4200

aactttgaca acgtgggggc cgggtacctg gcccttctgc aggtggcaac attttgtggc     4260

tggatggaca ttatgtatgc agctgtggac tccagggggt atgaagagca gcctcagtgg     4320

gaatacaacc tctacatgta catctatttt gtcattttca tcatctttgg gtctttcttc     4380

accctgaacc tctttattgg tgtcatcatt gacaacttca accaacagaa gaaaaagtta     4440

gggggccagg acatccaaat gacagaggag cagaagaagt actacaatgc catgaagaag     4500

ctgggctcca agaagcccca gaagcccatc ccacggcccc tgaacaagta ccagggcttc     4560

atattcgaca ttgtgaccaa gcaggccttt gacgtcacca tcatgtttct gatctgcttg     4620

aatatggtga ccatgatggt ggagacagat gaccaaagtc ctgagaaaat caacatcttg     4680

gccaagatca acctgctctt tgtggccatc ttcacaggcg agtgtattgt caagctggct     4740

gccctgcgcc actactactt caccaacagc tggaatatct tcgacttcgt ggttgtcatc     4800

ctctccatcg tgggcactgt gctctcggac atcatccaga agtacttctt ctccccgacg     4860

ctcttccgag tcatccgcct ggcccgaata ggccgcatcc tcagactgat ccgaggggcc     4920

aaggggatcc gcacgctgct ctttgccctc atgatgtccc tgcctgccct cttcaacatc     4980

gggctgctgc tcttcctcgt catgttcatc tactccatct ttggcatggc caacttcgct     5040

tatgtcaagt gggaggctgg catcgacgac atgttcaact tccagacctt cgccaacagc     5100

atgctgtgcc tcttccagat caccacgtcg gccggctggg atggcctcct cagccccatc     5160

ctcaacactg ggccgcccta ctgcgacccc actctgccca acagcaatgg ctctcggggg     5220

gactgcggga gcccagccgt gggcatcctc ttcttcacca cctacatcat catctccttc     5280

ctcatcgtgg tcaacatgta cattgccatc atcctggaga acttcagcgt ggccacggag     5340

gagagcaccg agcccctgag tgaggacgac ttcgatatgt tctatgagat ctgggagaaa     5400

tttgacccag aggccactca gtttattgag tattcggtcc tgtctgactt tgccgatgcc     5460

ctgtctgagc cactccgtat cgccaagccc aaccagataa gcctcatcaa catggacctg     5520

cccatggtga gtggggaccg catccattgc atggacattc tctttgcctt caccaaaagg     5580

gtcctggggg agtctgggga gatggacgcc ctgaagatcc agatggagga gaagttcatg     5640

gcagccaacc catccaagat ctcctacgag cccatcacca ccacactccg gcgcaagcac     5700

gaagaggtgt cggccatggt tatccagaga gccttccgca ggcacctgct gcaacgctct     5760

ttgaagcatg cctccttcct cttccgtcag caggcgggca gcggcctctc cgaagaggat     5820

gcccctgagc gagagggcct catcgcctac gtgatgagtg agaacttctc ccgacccctt     5880

ggcccaccct ccagctcctc catctcctcc acttccttcc caccctccta tgacagtgtc     5940

actagagcca ccagcgataa cctccaggtg cgggggtctg actacagcca cagtgaagat     6000

ctcgccgact tccccccttc tccggacagg gaccgtgagt ccatcgtgtg a              6051


<210>  2
<211>  6051
<212>  DNA
<213>  Homo sapiens

<400>  2
atggcaaact tcctattacc tcggggcacc agcagcttcc gcaggttcac acgggagtcc       60

ctggcagcca tcgagaagcg catggcagag aagcaagccc gcggctcaac caccttgcag      120

gagagccgag aggggctgcc cgaggaggag gctccccggc cccagctgga cctgcaggcc      180

tccaaaaagc tgccagatct ctatggcaat ccaccccaag agctcatcgg agagcccctg      240

gaggacctgg accccttcta tagcacccaa aagactttca tcgtactgaa taaaggcaag      300

accatcttcc ggttcagtgc caccaacgcc ttgtatgtcc tcagtccctt ccaccccatc      360

cggagagcgg ctgtgaagat tctggttcac tcgctcttca acatgctcat catgtgcacc      420

atcctcacca actgcgtgtt catggcccag cacgaccctc caccctggac caagtatgtc      480

gagtacacct tcaccgccat ttacaccttt gagtctctgg tcaagattct ggctcgaggc      540

ttctgcctgc acgcgttcac tttccttcgg gacccatgga actggctgga ctttagtgtg      600

attatcatgg catacacaac tgaatttgtg gacctgggca atgtctcagc cttacgcacc      660

ttccgagtcc tccgggccct gaaaactata tcagtcattt cagggctgaa gaccatcgtg      720

ggggccctga tccagtctgt gaagaagctg gctgatgtga tggtcctcac agtcttctgc      780

ctcagcgtct ttgccctcat cggcctgcag ctcttcatgg gcaacctaag gcacaagtgc      840

gtgcgcaact tcacagcgct caacggcacc aacggctccg tggaggccga cggcttggtc      900

tgggaatccc tggaccttta cctcagtgat ccagaaaatt acctgctcaa gaacggcacc      960

tctgatgtgt tactgtgtgg gaacagctct gacgctggga catgtccgga gggctaccgg     1020

tgcctaaagg caggcgagaa ccccgaccac ggctacacca gcttcgattc ctttgcctgg     1080

gcctttcttg cactcttccg cctgatgacg caggactgct gggagcgcct ctatcagcag     1140

accctcaggt ccgcagggaa gatctacatg atcttcttca tgcttgtcat cttcctgggg     1200

tccttctacc tggtgaacct gatcctggcc gtggtcgcaa tggcctatga ggagcaaaac     1260

caagccacca tcgctgagac cgaggagaag gaaaagcgct tccaggaggc catggaaatg     1320

ctcaagaaag aacacgaggc cctcaccatc aggggtgtgg ataccgtgtc ccgtagctcc     1380

ttggagatgt cccctttggc cccagtaaac agccatgaga gaagaagcaa gaggagaaaa     1440

cggatgtctt caggaactga ggagtgtggg gaggacaggc tccccaagtc tgactcagaa     1500

gatggtccca gagcaatgaa tcatctcagc ctcacccgtg gcctcagcag gacttctatg     1560

aagccacgtt ccagccgcgg gagcattttc acctttcgca ggcgagacct gggttctgaa     1620

gcagattttg cagatgatga aaacagcaca gcgggggaga gcgagagcca ccacacatca     1680

ctgctggtgc cctggcccct gcgccggacc agtgcccagg gacagcccag tcccggaacc     1740

tcggctcctg gccacgccct ccatggcaaa aagaacagca ctgtggactg caatggggtg     1800

gtctcattac tgggggcagg cgacccagag gccacatccc caggaagcca cctcctccgc     1860

cctgtgatgc tagagcaccc gccagacacg accacgccat cggaggagcc aggcgggccc     1920

cagatgctga cctcccaggc tccgtgtgta gatggcttcg aggagccagg agcacggcag     1980

cgggccctca gcgcagtcag cgtcctcacc agcgcactgg aagagttaga ggagtctcgc     2040

cacaagtgtc caccatgctg gaaccgtctc gcccagcgct acctgatctg ggagtgctgc     2100

ccgctgtgga tgtccatcaa gcagggagtg aagttggtgg tcatggaccc gtttactgac     2160

ctcaccatca ctatgtgcat cgtactcaac acactcttca tggcgctgga gcactacaac     2220

atgacaagtg aattcgagga gatgctgcag gtcggaaacc tggtcttcac agggattttc     2280

acagcagaga tgaccttcaa gatcattgcc ctcgacccct actactactt ccaacagggc     2340

tggaacatct tcgacagcat catcgtcatc cttagcctca tggagctggg cctgtcccgc     2400

atgagcaact tgtcggtgct gcgctccttc cgcctgctgc gggtcttcaa gctggccaaa     2460

tcatggccca ccctgaacac actcatcaag atcatcggga actcagtggg ggcactgggg     2520

aacctgacac tggtgctagc catcatcgtg ttcatctttg ctgtggtggg catgcagctc     2580

tttggcaaga actactcgga gctgagggac agcgactcag gcctgctgcc tcgctggcac     2640

atgatggact tctttcatgc cttcctcatc atcttccgca tcctctgtgg agagtggatc     2700

gagaccatgt gggactgcat ggaggtgtcg gggcagtcat tatgcctgct ggtcttcttg     2760

cttgttatgg tcattggcaa ccttgtggtc ctgaatctct tcctggcctt gctgctcagc     2820

tccttcagtg cagacaacct cacagcccct gatgaggaca gagagatgaa caacctccag     2880

ctggccctgg cccgcatcca gaggggcctg cgctttgtca agcggaccac ctgggatttc     2940

tgctgtggtc tcctgcggca gcggcctcag aagcccgcag cccttgccgc ccagggccag     3000

ctgcccagct gcattgccac cccctactcc ccgccacccc cagagacgga gaaggtgcct     3060

cccacccgca aggaaacacg gtttgaggaa ggcgagcaac caggccaggg cacccccggg     3120

gatccagagc ccgtgtgtgt gcccatcgct gtggccgagt cagacacaga tgaccaagaa     3180

gaagatgagg agaacagcct gggcacggag gaggagtcca gcaagcagca ggaatcccag     3240

cctgtgtccg gtggcccaga ggcccctccg gattccagga cctggagcca ggtgtcagcg     3300

actgcctcct ctgaggccga ggccagtgca tctcaggccg actggcggca gcagtggaaa     3360

gcggaacccc aggccccagg gtgcggtgag accccagagg acagttgctc cgagggcagc     3420

acagcagaca tgaccaacac cgctgagctc ctggagcaga tccctgacct cggccaggat     3480

gtcaaggacc cagaggactg cttcactgaa ggctgtgtcc ggcgctgtcc ctgctgtgcg     3540

gtggacacca cacaggcccc agggaaggtc tggtggcggt tgcgcaagac ctgctaccac     3600

atcgtggagc acagctggtt cgagacattc atcatcttca tgatcctact cagcagtgga     3660

gcgctggcct tcgaggacat ctacctagag gagcggaaga ccatcaaggt tctgcttgag     3720

tatgccgaca agatgttcac atatgtcttc gtgctggaga tgctgctcaa gtgggtggcc     3780

tacggcttca agaagtactt caccaatgcc tggtgctggc tcgacttcct catcgtagac     3840

gtctctctgg tcagcctggt ggccaacacc ctgggctttg ccgagatggg ccccatcaag     3900

tcactgcgga cgctgcgtgc actccgtcct ctgagagctc tgtcacgatt tgagggcatg     3960

agggtggtgg tcaatgccct ggtgggcgcc atcccgtcca tcatgaacgt cctcctcgtc     4020

tgcctcatct tctggctcat cttcagcatc atgggcgtga acctctttgc ggggaagttt     4080

gggaggtgca tcaaccagac agagggagac ttgcctttga actacaccat cgtgaacaac     4140

aagagccagt gtgagtcctt gaacttgacc ggagaattgt actggaccaa ggtgaaagtc     4200

aactttgaca acgtgggggc cgggtacctg gcccttctgc aggtggcaac attttgtggc     4260

tggatggaca ttatgtatgc agctgtggac tccagggggt atgaagagca gcctcagtgg     4320

gaatacaacc tctacatgta catctatttt gtcattttca tcatctttgg gtctttcttc     4380

accctgaacc tctttattgg tgtcatcatt gacaacttca accaacagaa gaaaaagtta     4440

gggggccagg acatccagat gacagaggag cagaagaagt actacaatgc catgaagaag     4500

ctgggctcca agaagcccca gaagcccatc ccacggcccc tgaacaagta ccagggcttc     4560

atattcgaca ttgtgaccaa gcaggccttt gacgtcacca tcatgtttct gatctgcttg     4620

aatatggtga ccatgatggt ggagacagat gaccaaagtc ctgagaaaat caacatcttg     4680

gccaagatca acctgctctt tgtggccatc ttcacaggcg agtgtattgt caagctggct     4740

gccctgcgcc actactactt caccaacagc tggaatatct tcgacttcgt ggttgtcatc     4800

ctctccatcg tgggcactgt gctctcggac atcatccaga agtacttctt ctccccgacg     4860

ctcttccgag tcatccgcct ggcccgaata ggccgcatcc tcagactgat ccgaggggcc     4920

aaggggatcc gcacgctgct ctttgccctc atgatgtccc tgcctgccct cttcaacatc     4980

gggctgctgc tcttcctcgt catgttcatc tactccatct ttggcatggc caacttcgct     5040

tatgtcaagt gggaggctgg catcgacgac atgttcaact tccagacctt cgccaacagc     5100

atgctgtgcc tcttccagat caccacgtcg gccggctggg atggcctcct cagccccatc     5160

ctcaacactg ggccgcccta ctgcgacccc actctgccca acagcaatgg ctctcggggg     5220

gactgcggga gcccagccgt gggcatcctc ttcttcacca cctacatcat catctccttc     5280

ctcatcgtgg tcaacatgta cattgccatc atcctggaga acttcagcgt ggccacggag     5340

gagagcaccg agcccctgag tgaggacgac ttcgatatgt tctatgagat ctgggagaaa     5400

tttgacccag aggccactca gtttattgag tattcggtcc tgtctgactt tgccgatgcc     5460

ctgtctgagc cactccgtat cgccaagccc aaccagataa gcctcatcaa catggacctg     5520

cccatggtga gtggggaccg catccattgc atggacattc tctttgcctt caccaaaagg     5580

gtcctggggg agtctgggga gatggacgcc ctgaagatcc agatggagga gaagttcatg     5640

gcagccaacc catccaagat ctcctacgag cccatcacca ccacactccg gcgcaagcac     5700

gaagaggtgt cggccatggt tatccagaga gccttccgca ggcacctgct gcaacgctct     5760

ttgaagcatg cctccttcct cttccgtcag caggcgggca gcggcctctc cgaagaggat     5820

gcccctgagc gagagggcct catcgcctac gtgatgagtg agaacttctc ccgacccctt     5880

ggcccaccct ccagctcctc catctcctcc acttccttcc caccctccta tgacagtgtc     5940

actagagcca ccagcgataa cctccaggtg cgggggtctg actacagcca cagtgaagat     6000

ctcgccgact tccccccttc tccggacagg gaccgtgagt ccatcgtgtg a              6051


<210>  3
<211>  6051
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcaaact tcctattacc tcggggcacc agcagcttcc gcaggttcac acgggagtcc       60

ctggcagcca tcgagaagcg catggcagag aagcaagccc gcggctcaac caccttgcag      120

gagagccgag aggggctgcc cgaggaggag gctccccggc cccagctgga cctgcaggcc      180

tccaaaaagc tgccagatct ctatggcaat ccaccccaag agctcatcgg agagcccctg      240

gaggacctgg accccttcta tagcacccaa aagactttca tcgtactgaa taaaggcaag      300

accatcttcc ggttcagtgc caccaacgcc ttgtatgtcc tcagtccctt ccaccccatc      360

cggagagcgg ctgtgaagat tctggttcac tcgctcttca acatgctcat catgtgcacc      420

atcctcacca actgcgtgtt catggcccag cacgaccctc caccctggac caagtatgtc      480

gagtacacct tcaccgccat ttacaccttt gagtctctgg tcaagattct ggctcgaggc      540

ttctgcctgc acgcgttcac tttccttcgg gacccatgga actggctgga ctttagtgtg      600

attatcatgg catacacaac tgaatttgtg gacctgggca atgtctcagc cttacgcacc      660

ttccgagtcc tccgggccct gaaaactata tcagtcattt cagggctgaa gaccatcgtg      720

ggggccctga tccagtctgt gaagaagctg gctgatgtga tggtcctcac agtcttctgc      780

ctcagcgtct ttgccctcat cggcctgcag ctcttcatgg gcaacctaag gcacaagtgc      840

gtgcgcaact tcacagcgct caacggcacc aacggctccg tggaggccga cggcttggtc      900

tgggaatccc tggaccttta cctcagtgat ccagaaaatt acctgctcaa gaacggcacc      960

tctgatgtgt tactgtgtgg gaacagctct gacgctggga catgtccgga gggctaccgg     1020

tgcctaaagg caggcgagaa ccccgaccac ggctacacca gcttcgattc ctttgcctgg     1080

gcctttcttg cactcttccg cctgatgacg caggactgct gggagcgcct ctatcagcag     1140

accctcaggt ccgcagggaa gatctacatg atcttcttca tgcttgtcat cttcctgggg     1200

tccttctacc tggtgaacct gatcctggcc gtggtcgcaa tggcctatga ggagcaaaac     1260

caagccacca tcgctgagac cgaggagaag gaaaagcgct tccaggaggc catggaaatg     1320

ctcaagaaag aacacgaggc cctcaccatc aggggtgtgg ataccgtgtc ccgtagctcc     1380

ttggagatgt cccctttggc cccagtaaac agccatgaga gaagaagcaa gaggagaaaa     1440

cggatgtctt caggaactga ggagtgtggg gaggacaggc tccccaagtc tgactcagaa     1500

gatggtccca gagcaatgaa tcatctcagc ctcacccgtg gcctcagcag gacttctatg     1560

aagccacgtt ccagccgcgg gagcattttc acctttcgca ggcgagacct gggttctgaa     1620

gcagattttg cagatgatga aaacagcaca gcgggggaga gcgagagcca ccacacatca     1680

ctgctggtgc cctggcccct gcgccggacc agtgcccagg gacagcccag tcccggaacc     1740

tcggctcctg gccacgccct ccatggcaaa aagaacagca ctgtggactg caatggggtg     1800

gtctcattac tgggggcagg cgacccagag gccacatccc caggaagcca cctcctccgc     1860

cctgtgatgc tagagcaccc gccagacacg accacgccat cggaggagcc aggcgggccc     1920

cagatgctga cctcccaggc tccgtgtgta gatggcttcg aggagccagg agcacggcag     1980

cgggccctca gcgcagtcag cgtcctcacc agcgcactgg aagagttaga ggagtctcgc     2040

cacaagtgtc caccatgctg gaaccgtctc gcccagcgct acctgatctg ggagtgctgc     2100

ccgctgtgga tgtccatcaa gcagggagtg aagttggtgg tcatggaccc gtttactgac     2160

ctcaccatca ctatgtgcat cgtactcaac acactcttca tggcgctgga gcactacaac     2220

atgacaagtg aattcgagga gatgctgcag gtcggaaacc tggtcttcac agggattttc     2280

acagcagaga tgaccttcaa gatcattgcc ctcgacccct actactactt ccaacagggc     2340

tggaacatct tcgacagcat catcgtcatc cttagcctca tggagctggg cctgtcccgc     2400

atgagcaact tgtcggtgct gcgctccttc cgcctgctgc gggtcttcaa gctggccaaa     2460

tcatggccca ccctgaacac actcatcaag atcatcggga actcagtggg ggcactgggg     2520

aacctgacac tggtgctagc catcatcgtg ttcatctttg ctgtggtggg catgcagctc     2580

tttggcaaga actactcgga gctgagggac agcgactcag gcctgctgcc tcgctggcac     2640

atgatggact tctttcatgc cttcctcatc atcttccgca tcctctgtgg agagtggatc     2700

gagaccatgt gggactgcat ggaggtgtcg gggcagtcat tatgcctgct ggtcttcttg     2760

cttgttatgg tcattggcaa ccttgtggtc ctgaatctct tcctggcctt gctgctcagc     2820

tccttcagtg cagacaacct cacagcccct gatgaggaca gagagatgaa caacctccag     2880

ctggccctgg cccgcatcca gaggggcctg cgctttgtca agcggaccac ctgggatttc     2940

tgctgtggtc tcctgcggca gcggcctcag aagcccgcag cccttgccgc ccagggccag     3000

ctgcccagct gcattgccac cccctactcc ccgccacccc cagagacgga gaaggtgcct     3060

cccacccgca aggaaacacg gtttgaggaa ggcgagcaac caggccaggg cacccccggg     3120

gatccagagc ccgtgtgtgt gcccatcgct gtggccgagt cagacacaga tgaccaagaa     3180

gaagatgagg agaacagcct gggcacggag gaggagtcca gcaagcagca ggaatcccag     3240

cctgtgtccg gtggcccaga ggcccctccg gattccagga cctggagcca ggtgtcagcg     3300

actgcctcct ctgaggccga ggccagtgca tctcaggccg actggcggca gcagtggaaa     3360

gcggaacccc aggccccagg gtgcggtgag accccagagg acagttgctc cgagggcagc     3420

acagcagaca tgaccaacac cgctgagctc ctggagcaga tccctgacct cggccaggat     3480

gtcaaggacc cagaggactg cttcactgaa ggctgtgtcc ggcgctgtcc ctgctgtgcg     3540

gtggacacca cacaggcccc agggaaggtc tggtggcggt tgcgcaagac ctgctaccac     3600

atcgtggagc acagctggtt cgagacattc atcatcttca tgatcctact cagcagtgga     3660

gcgctggcct tcgaggacat ctacctagag gagcggaaga ccatcaaggt tctgcttgag     3720

tatgccgaca agatgttcac atatgtcttc gtgctggaga tgctgctcaa gtgggtggcc     3780

tacggcttca agaagtactt caccaatgcc tggtgctggc tcgacttcct catcgtagac     3840

gtctctctgg tcagcctggt ggccaacacc ctgggctttg ccgagatggg ccccatcaag     3900

tcactgcgga cgctgcgtgc actccgtcct ctgagagctc tgtcacgatt tgagggcatg     3960

agggtggtgg tcaatgccct ggtgggcgcc atcccgtcca tcatgaacgt cctcctcgtc     4020

tgcctcatct tctggctcat cttcagcatc atgggcgtga acctctttgc ggggaagttt     4080

gggaggtgca tcaaccagac agagggagac ttgcctttga actacaccat cgtgaacaac     4140

aagagccagt gtgagtcctt gaacttgacc ggagaattgt actggaccaa ggtgaaagtc     4200

aactttgaca acgtgggggc cgggtacctg gcccttctgc aggtggcaac attttgcggc     4260

tggatggaca ttatgtatgc agctgtggac tccagggggt atgaagagca gcctcagtgg     4320

gaatacaacc tctacatgta catctatttt gtcattttca tcatctttgg gtctttcttc     4380

accctgaacc tctttattgg tgtcatcatt gacaacttca accaacagaa gaaaaagtta     4440

gggggccagg acatccaaat gacagaggag cagaagaagt actacaatgc catgaagaag     4500

ctgggctcca agaagcccca gaagcccatc ccacggcccc tgaacaagta ccagggcttc     4560

atattcgaca ttgtgaccaa gcaggccttt gacgtcacca tcatgtttct gatctgcttg     4620

aatatggtga ccatgatggt ggagacagat gaccaaagtc ctgagaaaat caacatcttg     4680

gccaagatca acctgctctt tgtggccatc ttcacaggcg agtgtattgt caagctggct     4740

gccctgcgcc actactactt caccaacagc tggaatatct tcgacttcgt ggttgtcatc     4800

ctctccatcg tgggcactgt gctctcggac atcatccaga agtacttctt ctccccgacg     4860

ctcttccgag tcatccgcct ggcccgaata ggccgcatcc tcagactgat ccgaggggcc     4920

aaggggatcc gcacgctgct ctttgccctc atgatgtccc tgcctgccct cttcaacatc     4980

gggctgctgc tcttcctcgt catgttcatc tactccatct ttggcatggc caacttcgct     5040

tatgtcaagt gggaggctgg catcgacgac atgttcaact tccagacctt cgccaacagc     5100

atgctgtgcc tcttccagat caccacgtcg gccggctggg atggcctcct cagccccatc     5160

ctcaacactg ggccgcccta ctgcgacccc actctgccca acagcaatgg ctctcggggg     5220

gactgcggga gcccagccgt gggcatcctc ttcttcacca cctacatcat catctccttc     5280

ctcatcgtgg tcaacatgta cattgccatc atcctggaga acttcagcgt ggccacggag     5340

gagagcaccg agcccctgag tgaggacgac ttcgatatgt tctatgagat ctgggagaaa     5400

tttgacccag aggccactca gtttattgag tattcggtcc tgtctgactt tgccgatgcc     5460

ctgtctgagc cactccgtat cgccaagccc aaccagataa gcctcatcaa catggacctg     5520

cccatggtga gtggggaccg catccattgc atggacattc tctttgcctt caccaaaagg     5580

gtcctggggg agtctgggga gatggacgcc ctgaagatcc agatggagga gaagttcatg     5640

gcagccaacc catccaagat ctcctacgag cccatcacca ccacactccg gcgcaagcac     5700

gaagaggtgt cggccatggt tatccagaga gccttccgca ggcacctgct gcaacgctct     5760

ttgaagcatg cctccttcct cttccgtcag caggcgggca gcggcctctc cgaagaggat     5820

gcccctgagc gagagggcct catcgcctac gtgatgagtg agaacttctc ccgacccctt     5880

ggcccaccct ccagctcctc catctcctcc acttccttcc caccctccta tgacagtgtc     5940

actagagcca ccagcgataa cctccaggtg cgggggtctg actacagcca cagtgaagat     6000

ctcgccgact tccccccttc tccggacagg gaccgtgagt ccatcgtgtg a              6051


<210>  4
<211>  6051
<212>  DNA
<213>  Homo sapiens

<400>  4
atggcaaact tcctattacc tcggggcacc agcagcttcc gcaggttcac acgggagtcc       60

ctggcagcca tcgagaagcg catggcagag aagcaagccc gcggctcaac caccttgcag      120

gagagccgag aggggctgcc cgaggaggag gctccccggc cccagctgga cctgcaggcc      180

tccaaaaagc tgccagatct ctatggcaat ccaccccaag agctcatcgg agagcccctg      240

gaggacctgg accccttcta tagcacccaa aagactttca tcgtactgaa taaaggcaag      300

accatcttcc ggttcagtgc caccaacgcc ttgtatgtcc tcagtccctt ccaccccatc      360

cggagagcgg ctgtgaagat tctggttcac tcgctcttca acatgctcat catgtgcacc      420

atcctcacca actgcgtgtt catggcccag cacgaccctc caccctggac caagtatgtc      480

gagtacacct tcaccgccat ttacaccttt gagtctctgg tcaagattct ggctcgaggc      540

ttctgcctgc acgcgttcac tttccttcgg gacccatgga actggctgga ctttagtgtg      600

attatcatgg catacacaac tgaatttgtg gacctgggca atgtctcagc cttacgcacc      660

ttccgagtcc tccgggccct gaaaactata tcagtcattt cagggctgaa gaccatcgtg      720

ggggccctga tccagtctgt gaagaagctg gctgatgtga tggtcctcac agtcttctgc      780

ctcagcgtct ttgccctcat cggcctgcag ctcttcatgg gcaacctaag gcacaagtgc      840

gtgcgcaact tcacagcgct caacggcacc aacggctccg tggaggccga cggcttggtc      900

tgggaatccc tggaccttta cctcagtgat ccagaaaatt acctgctcaa gaacggcacc      960

tctgatgtgt tactgtgtgg gaacagctct gacgctggga catgtccgga gggctaccgg     1020

tgcctaaagg caggcgagaa ccccgaccac ggctacacca gcttcgattc ctttgcctgg     1080

gcctttcttg cactcttccg cctgatgacg caggactgct gggagcgcct ctatcagcag     1140

accctcaggt ccgcagggaa gatctacatg atcttcttca tgcttgtcat cttcctgggg     1200

tccttctacc tggtgaacct gatcctggcc gtggtcgcaa tggcctatga ggagcaaaac     1260

caagccacca tcgctgagac cgaggagaag gaaaagcgct tccaggaggc catggaaatg     1320

ctcaagaaag aacacgaggc cctcaccatc aggggtgtgg ataccgtgtc ccgtagctcc     1380

ttggagatgt cccctttggc cccagtaaac agccatgaga gaagaagcaa gaggagaaaa     1440

cggatgtctt caggaactga ggagtgtggg gaggacaggc tccccaagtc tgactcagaa     1500

gatggtccca gagcaatgaa tcatctcagc ctcacccgtg gcctcagcag gacttctatg     1560

aagccacgtt ccagccgcgg gagcattttc acctttcgca ggcgagacct gggttctgaa     1620

gcagattttg cagatgatga aaacagcaca gcgggggaga gcgagagcca ccacacatca     1680

ctgctggtgc cctggcccct gcgccggacc agtgcccagg gacagcccag tcccggaacc     1740

tcggctcctg gccacgccct ccatggcaaa aagaacagca ctgtggactg caatggggtg     1800

gtctcattac tgggggcagg cgacccagag gccacatccc caggaagcca cctcctccgc     1860

cctgtgatgc tagagcaccc gccagacacg accacgccat cggaggagcc aggcgggccc     1920

cagatgctga cctcccaggc tccgtgtgta gatggcttcg aggagccagg agcacggcag     1980

cgggccctca gcgcagtcag cgtcctcacc agcgcactgg aagagttaga ggagtctcgc     2040

cacaagtgtc caccatgctg gaaccgtctc gcccagcgct acctgatctg ggagtgctgc     2100

ccgctgtgga tgtccatcaa gcagggagtg aagttggtgg tcatggaccc gtttactgac     2160

ctcaccatca ctatgtgcat cgtactcaac acactcttca tggcgctgga gcactacaac     2220

atgacaagtg aattcgagga gatgctgcag gtcggaaacc tggtcttcac agggattttc     2280

acagcagaga tgaccttcaa gatcattgcc ctcgacccct actactactt ccaacagggc     2340

tggaacatct tcgacagcat catcgtcatc cttagcctca tggagctggg cctgtcccgc     2400

atgagcaact tgtcggtgct gcgctccttc cgcctgctgc gggtcttcaa gctggccaaa     2460

tcatggccca ccctgaacac actcatcaag atcatcggga actcagtggg ggcactgggg     2520

aacctgacac tggtgctagc catcatcgtg ttcatctttg ctgtggtggg catgcagctc     2580

tttggcaaga actactcgga gctgagggac agcgactcag gcctgctgcc tcgctggcac     2640

atgatggact tctttcatgc cttcctcatc atcttccgca tcctctgtgg agagtggatc     2700

gagaccatgt gggactgcat ggaggtgtcg gggcagtcat tatgcctgct ggtcttcttg     2760

cttgttatgg tcattggcaa ccttgtggtc ctgaatctct tcctggcctt gctgctcagc     2820

tccttcagtg cagacaacct cacagcccct gatgaggaca gagagatgaa caacctccag     2880

ctggccctgg cccgcatcca gaggggcctg cgctttgtca agcggaccac ctgggatttc     2940

tgctgtggtc tcctgcggca gcggcctcag aagcccgcag cccttgccgc ccagggccag     3000

ctgcccagct gcattgccac cccctactcc ccgccacccc cagagacgga gaaggtgcct     3060

cccacccgca aggaaacacg gtttgaggaa ggcgagcaac caggccaggg cacccccggg     3120

gatccagagc ccgtgtgtgt gcccatcgct gtggccgagt cagacacaga tgaccaagaa     3180

gaagatgagg agaacagcct gggcacggag gaggagtcca gcaagcagca ggaatcccag     3240

cctgtgtccg gtggcccaga ggcccctccg gattccagga cctggagcca ggtgtcagcg     3300

actgcctcct ctgaggccga ggccagtgca tctcaggccg actggcggca gcagtggaaa     3360

gcggaacccc aggccccagg gtgcggtgag accccagagg acagttgctc cgagggcagc     3420

acagcagaca tgaccaacac cgctgagctc ctggagcaga tccctgacct cggccaggat     3480

gtcaaggacc cagaggactg cttcactgaa ggctgtgtcc ggcgctgtcc ctgctgtgcg     3540

gtggacacca cacaggcccc agggaaggtc tggtggcggt tgcgcaagac ctgctaccac     3600

atcgtggagc acagctggtt cgagacattc atcatcttca tgatcctact cagcagtgga     3660

gcgctggcct tcgaggacat ctacctagag gagcggaaga ccatcaaggt tctgcttgag     3720

tatgccgaca agatgttcac atatgtcttc gtgctggaga tgctgctcaa gtgggtggcc     3780

tacggcttca agaagtactt caccaatgcc tggtgctggc tcgacttcct catcgtagac     3840

gtctctctgg tcagcctggt ggccaacacc ctgggctttg ccgagatggg ccccatcaag     3900

tcactgcgga cgctgcgtgc actccgtcct ctgagagctc tgtcacgatt tgagggcatg     3960

agggtggtgg tcaatgccct ggtgggcgcc atcccgtcca tcatgaacgt cctcctcgtc     4020

tgcctcatct tctggctcat cttcagcatc atgggcgtga acctctttgc ggggaagttt     4080

gggaggtgca tcaaccagac agagggagac ttgcctttga actacaccat cgtgaacaac     4140

aagagccagt gtgagtcctt gaacttgacc ggagaattgt actggaccaa ggtgaaagtc     4200

aactttgaca acgtgggggc cgggtacctg gcccttctgc aggtggcaac attttgcggc     4260

tggatggaca ttatgtatgc agctgtggac tccagggggt atgaagagca gcctcagtgg     4320

gaatacaacc tctacatgta catctatttt gtcattttca tcatctttgg gtctttcttc     4380

accctgaacc tctttattgg tgtcatcatt gacaacttca accaacagaa gaaaaagtta     4440

gggggccagg acatccagat gacagaggag cagaagaagt actacaatgc catgaagaag     4500

ctgggctcca agaagcccca gaagcccatc ccacggcccc tgaacaagta ccagggcttc     4560

atattcgaca ttgtgaccaa gcaggccttt gacgtcacca tcatgtttct gatctgcttg     4620

aatatggtga ccatgatggt ggagacagat gaccaaagtc ctgagaaaat caacatcttg     4680

gccaagatca acctgctctt tgtggccatc ttcacaggcg agtgtattgt caagctggct     4740

gccctgcgcc actactactt caccaacagc tggaatatct tcgacttcgt ggttgtcatc     4800

ctctccatcg tgggcactgt gctctcggac atcatccaga agtacttctt ctccccgacg     4860

ctcttccgag tcatccgcct ggcccgaata ggccgcatcc tcagactgat ccgaggggcc     4920

aaggggatcc gcacgctgct ctttgccctc atgatgtccc tgcctgccct cttcaacatc     4980

gggctgctgc tcttcctcgt catgttcatc tactccatct ttggcatggc caacttcgct     5040

tatgtcaagt gggaggctgg catcgacgac atgttcaact tccagacctt cgccaacagc     5100

atgctgtgcc tcttccagat caccacgtcg gccggctggg atggcctcct cagccccatc     5160

ctcaacactg ggccgcccta ctgcgacccc actctgccca acagcaatgg ctctcggggg     5220

gactgcggga gcccagccgt gggcatcctc ttcttcacca cctacatcat catctccttc     5280

ctcatcgtgg tcaacatgta cattgccatc atcctggaga acttcagcgt ggccacggag     5340

gagagcaccg agcccctgag tgaggacgac ttcgatatgt tctatgagat ctgggagaaa     5400

tttgacccag aggccactca gtttattgag tattcggtcc tgtctgactt tgccgatgcc     5460

ctgtctgagc cactccgtat cgccaagccc aaccagataa gcctcatcaa catggacctg     5520

cccatggtga gtggggaccg catccattgc atggacattc tctttgcctt caccaaaagg     5580

gtcctggggg agtctgggga gatggacgcc ctgaagatcc agatggagga gaagttcatg     5640

gcagccaacc catccaagat ctcctacgag cccatcacca ccacactccg gcgcaagcac     5700

gaagaggtgt cggccatggt tatccagaga gccttccgca ggcacctgct gcaacgctct     5760

ttgaagcatg cctccttcct cttccgtcag caggcgggca gcggcctctc cgaagaggat     5820

gcccctgagc gagagggcct catcgcctac gtgatgagtg agaacttctc ccgacccctt     5880

ggcccaccct ccagctcctc catctcctcc acttccttcc caccctccta tgacagtgtc     5940

actagagcca ccagcgataa cctccaggtg cgggggtctg actacagcca cagtgaagat     6000

ctcgccgact tccccccttc tccggacagg gaccgtgagt ccatcgtgtg a              6051


<210>  5
<211>  2016
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Cys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Gln Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Thr Val Leu 
    1595                 1600                 1605             


Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro Thr  Leu Phe Arg 
    1610                 1615                 1620             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg 
    1625                 1630                 1635             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1640                 1645                 1650             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1655                 1660                 1665             


Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe Ala  Tyr Val Lys 
    1670                 1675                 1680             


Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala 
    1685                 1690                 1695             


Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1700                 1705                 1710             


Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys 
    1715                 1720                 1725             


Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg Gly  Asp Cys Gly 
    1730                 1735                 1740             


Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr Tyr  Ile Ile Ile 
    1745                 1750                 1755             


Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala Ile  Ile Leu Glu 
    1760                 1765                 1770             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1775                 1780                 1785             


Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu Lys  Phe Asp Pro 
    1790                 1795                 1800             


Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu Ser  Asp Phe Ala 
    1805                 1810                 1815             


Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys Pro  Asn Gln Ile 
    1820                 1825                 1830             


Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1835                 1840                 1845             


His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1850                 1855                 1860             


Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln Met  Glu Glu Lys 
    1865                 1870                 1875             


Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr Glu  Pro Ile Thr 
    1880                 1885                 1890             


Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser Ala  Met Val Ile 
    1895                 1900                 1905             


Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg Ser  Leu Lys His 
    1910                 1915                 1920             


Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser Gly  Leu Ser Glu 
    1925                 1930                 1935             


Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala Tyr  Val Met Ser 
    1940                 1945                 1950             


Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser Ser  Ser Ser Ile 
    1955                 1960                 1965             


Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser Val  Thr Arg Ala 
    1970                 1975                 1980             


Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp Tyr  Ser His Ser 
    1985                 1990                 1995             


Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp Arg  Asp Arg Glu 
    2000                 2005                 2010             


Ser Ile  Val 
    2015     


<210>  6
<211>  8504
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (195)..(6245)

<400>  6
agacggcggc ggcgcccgta ggatgcaggg atcgctcccc cggggccgct gagcctgcgc       60

ccagtgcccc gagccccgcg ccgagccgag tccgcgccaa gcagcagccg cccaccccgg      120

ggcccggccg ggggaccagc agcttcccca caggcaacgt gaggagagcc tgtgcccaga      180

agcaggatga gaag atg gca aac ttc cta tta cct cgg ggc acc agc agc        230
                Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser           
                1               5                   10                    

ttc cgc agg ttc aca cgg gag tcc ctg gca gcc atc gag aag cgc atg        278
Phe Arg Arg Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met           
        15                  20                  25                        

gca gag aag caa gcc cgc ggc tca acc acc ttg cag gag agc cga gag        326
Ala Glu Lys Gln Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu           
    30                  35                  40                            

ggg ctg ccc gag gag gag gct ccc cgg ccc cag ctg gac ctg cag gcc        374
Gly Leu Pro Glu Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala           
45                  50                  55                  60            

tcc aaa aag ctg cca gat ctc tat ggc aat cca ccc caa gag ctc atc        422
Ser Lys Lys Leu Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile           
                65                  70                  75                

gga gag ccc ctg gag gac ctg gac ccc ttc tat agc acc caa aag act        470
Gly Glu Pro Leu Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr           
            80                  85                  90                    

ttc atc gta ctg aat aaa ggc aag acc atc ttc cgg ttc agt gcc acc        518
Phe Ile Val Leu Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr           
        95                  100                 105                       

aac gcc ttg tat gtc ctc agt ccc ttc cac ccc atc cgg aga gcg gct        566
Asn Ala Leu Tyr Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala           
    110                 115                 120                           

gtg aag att ctg gtt cac tcg ctc ttc aac atg ctc atc atg tgc acc        614
Val Lys Ile Leu Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr           
125                 130                 135                 140           

atc ctc acc aac tgc gtg ttc atg gcc cag cac gac cct cca ccc tgg        662
Ile Leu Thr Asn Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp           
                145                 150                 155               

acc aag tat gtc gag tac acc ttc acc gcc att tac acc ttt gag tct        710
Thr Lys Tyr Val Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser           
            160                 165                 170                   

ctg gtc aag att ctg gct cga ggc ttc tgc ctg cac gcg ttc act ttc        758
Leu Val Lys Ile Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe           
        175                 180                 185                       

ctt cgg gac cca tgg aac tgg ctg gac ttt agt gtg att atc atg gca        806
Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala           
    190                 195                 200                           

tac aca act gaa ttt gtg gac ctg ggc aat gtc tca gcc tta cgc acc        854
Tyr Thr Thr Glu Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr           
205                 210                 215                 220           

ttc cga gtc ctc cgg gcc ctg aaa act ata tca gtc att tca ggg ctg        902
Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu           
                225                 230                 235               

aag acc atc gtg ggg gcc ctg atc cag tct gtg aag aag ctg gct gat        950
Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp           
            240                 245                 250                   

gtg atg gtc ctc aca gtc ttc tgc ctc agc gtc ttt gcc ctc atc ggc        998
Val Met Val Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly           
        255                 260                 265                       

ctg cag ctc ttc atg ggc aac cta agg cac aag tgc gtg cgc aac ttc       1046
Leu Gln Leu Phe Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe           
    270                 275                 280                           

aca gcg ctc aac ggc acc aac ggc tcc gtg gag gcc gac ggc ttg gtc       1094
Thr Ala Leu Asn Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val           
285                 290                 295                 300           

tgg gaa tcc ctg gac ctt tac ctc agt gat cca gaa aat tac ctg ctc       1142
Trp Glu Ser Leu Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu           
                305                 310                 315               

aag aac ggc acc tct gat gtg tta ctg tgt ggg aac agc tct gac gct       1190
Lys Asn Gly Thr Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala           
            320                 325                 330                   

ggg aca tgt ccg gag ggc tac cgg tgc cta aag gca ggc gag aac ccc       1238
Gly Thr Cys Pro Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro           
        335                 340                 345                       

gac cac ggc tac acc agc ttc gat tcc ttt gcc tgg gcc ttt ctt gca       1286
Asp His Gly Tyr Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala           
    350                 355                 360                           

ctc ttc cgc ctg atg acg cag gac tgc tgg gag cgc ctc tat cag cag       1334
Leu Phe Arg Leu Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln           
365                 370                 375                 380           

acc ctc agg tcc gca ggg aag atc tac atg atc ttc ttc atg ctt gtc       1382
Thr Leu Arg Ser Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val           
                385                 390                 395               

atc ttc ctg ggg tcc ttc tac ctg gtg aac ctg atc ctg gcc gtg gtc       1430
Ile Phe Leu Gly Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val           
            400                 405                 410                   

gca atg gcc tat gag gag caa aac caa gcc acc atc gct gag acc gag       1478
Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu           
        415                 420                 425                       

gag aag gaa aag cgc ttc cag gag gcc atg gaa atg ctc aag aaa gaa       1526
Glu Lys Glu Lys Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu           
    430                 435                 440                           

cac gag gcc ctc acc atc agg ggt gtg gat acc gtg tcc cgt agc tcc       1574
His Glu Ala Leu Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser           
445                 450                 455                 460           

ttg gag atg tcc cct ttg gcc cca gta aac agc cat gag aga aga agc       1622
Leu Glu Met Ser Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser           
                465                 470                 475               

aag agg aga aaa cgg atg tct tca gga act gag gag tgt ggg gag gac       1670
Lys Arg Arg Lys Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp           
            480                 485                 490                   

agg ctc ccc aag tct gac tca gaa gat ggt ccc aga gca atg aat cat       1718
Arg Leu Pro Lys Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His           
        495                 500                 505                       

ctc agc ctc acc cgt ggc ctc agc agg act tct atg aag cca cgt tcc       1766
Leu Ser Leu Thr Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser           
    510                 515                 520                           

agc cgc ggg agc att ttc acc ttt cgc agg cga gac ctg ggt tct gaa       1814
Ser Arg Gly Ser Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu           
525                 530                 535                 540           

gca gat ttt gca gat gat gaa aac agc aca gcg ggg gag agc gag agc       1862
Ala Asp Phe Ala Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser           
                545                 550                 555               

cac cac aca tca ctg ctg gtg ccc tgg ccc ctg cgc cgg acc agt gcc       1910
His His Thr Ser Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala           
            560                 565                 570                   

cag gga cag ccc agt ccc gga acc tcg gct cct ggc cac gcc ctc cat       1958
Gln Gly Gln Pro Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His           
        575                 580                 585                       

ggc aaa aag aac agc act gtg gac tgc aat ggg gtg gtc tca tta ctg       2006
Gly Lys Lys Asn Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu           
    590                 595                 600                           

ggg gca ggc gac cca gag gcc aca tcc cca gga agc cac ctc ctc cgc       2054
Gly Ala Gly Asp Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg           
605                 610                 615                 620           

cct gtg atg cta gag cac ccg cca gac acg acc acg cca tcg gag gag       2102
Pro Val Met Leu Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu           
                625                 630                 635               

cca ggc ggg ccc cag atg ctg acc tcc cag gct ccg tgt gta gat ggc       2150
Pro Gly Gly Pro Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly           
            640                 645                 650                   

ttc gag gag cca gga gca cgg cag cgg gcc ctc agc gca gtc agc gtc       2198
Phe Glu Glu Pro Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val           
        655                 660                 665                       

ctc acc agc gca ctg gaa gag tta gag gag tct cgc cac aag tgt cca       2246
Leu Thr Ser Ala Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro           
    670                 675                 680                           

cca tgc tgg aac cgt ctc gcc cag cgc tac ctg atc tgg gag tgc tgc       2294
Pro Cys Trp Asn Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys           
685                 690                 695                 700           

ccg ctg tgg atg tcc atc aag cag gga gtg aag ttg gtg gtc atg gac       2342
Pro Leu Trp Met Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp           
                705                 710                 715               

ccg ttt act gac ctc acc atc act atg tgc atc gta ctc aac aca ctc       2390
Pro Phe Thr Asp Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu           
            720                 725                 730                   

ttc atg gcg ctg gag cac tac aac atg aca agt gaa ttc gag gag atg       2438
Phe Met Ala Leu Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met           
        735                 740                 745                       

ctg cag gtc gga aac ctg gtc ttc aca ggg att ttc aca gca gag atg       2486
Leu Gln Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met           
    750                 755                 760                           

acc ttc aag atc att gcc ctc gac ccc tac tac tac ttc caa cag ggc       2534
Thr Phe Lys Ile Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly           
765                 770                 775                 780           

tgg aac atc ttc gac agc atc atc gtc atc ctt agc ctc atg gag ctg       2582
Trp Asn Ile Phe Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu           
                785                 790                 795               

ggc ctg tcc cgc atg agc aac ttg tcg gtg ctg cgc tcc ttc cgc ctg       2630
Gly Leu Ser Arg Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu           
            800                 805                 810                   

ctg cgg gtc ttc aag ctg gcc aaa tca tgg ccc acc ctg aac aca ctc       2678
Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu           
        815                 820                 825                       

atc aag atc atc ggg aac tca gtg ggg gca ctg ggg aac ctg aca ctg       2726
Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu           
    830                 835                 840                           

gtg cta gcc atc atc gtg ttc atc ttt gct gtg gtg ggc atg cag ctc       2774
Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu           
845                 850                 855                 860           

ttt ggc aag aac tac tcg gag ctg agg gac agc gac tca ggc ctg ctg       2822
Phe Gly Lys Asn Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu           
                865                 870                 875               

cct cgc tgg cac atg atg gac ttc ttt cat gcc ttc ctc atc atc ttc       2870
Pro Arg Trp His Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe           
            880                 885                 890                   

cgc atc ctc tgt gga gag tgg atc gag acc atg tgg gac tgc atg gag       2918
Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu           
        895                 900                 905                       

gtg tcg ggg cag tca tta tgc ctg ctg gtc ttc ttg ctt gtt atg gtc       2966
Val Ser Gly Gln Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val           
    910                 915                 920                           

att ggc aac ctt gtg gtc ctg aat ctc ttc ctg gcc ttg ctg ctc agc       3014
Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser           
925                 930                 935                 940           

tcc ttc agt gca gac aac ctc aca gcc cct gat gag gac aga gag atg       3062
Ser Phe Ser Ala Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met           
                945                 950                 955               

aac aac ctc cag ctg gcc ctg gcc cgc atc cag agg ggc ctg cgc ttt       3110
Asn Asn Leu Gln Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe           
            960                 965                 970                   

gtc aag cgg acc acc tgg gat ttc tgc tgt ggt ctc ctg cgg cag cgg       3158
Val Lys Arg Thr Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg           
        975                 980                 985                       

cct cag aag ccc gca gcc ctt gcc gcc cag ggc cag  ctg ccc agc tgc      3206
Pro Gln Lys Pro Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys          
    990                 995                 1000                          

att  gcc acc ccc tac tcc  ccg cca ccc cca gag  acg gag aag gtg        3251
Ile  Ala Thr Pro Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val            
1005                 1010                 1015                            

cct  ccc acc cgc aag gaa  aca cgg ttt gag gaa  ggc gag caa cca        3296
Pro  Pro Thr Arg Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro            
1020                 1025                 1030                            

ggc  cag ggc acc ccc ggg  gat cca gag ccc gtg  tgt gtg ccc atc        3341
Gly  Gln Gly Thr Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile            
1035                 1040                 1045                            

gct  gtg gcc gag tca gac  aca gat gac caa gaa  gaa gat gag gag        3386
Ala  Val Ala Glu Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu            
1050                 1055                 1060                            

aac  agc ctg ggc acg gag  gag gag tcc agc aag  cag cag gaa tcc        3431
Asn  Ser Leu Gly Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser            
1065                 1070                 1075                            

cag  cct gtg tcc ggt ggc  cca gag gcc cct ccg  gat tcc agg acc        3476
Gln  Pro Val Ser Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr            
1080                 1085                 1090                            

tgg  agc cag gtg tca gcg  act gcc tcc tct gag  gcc gag gcc agt        3521
Trp  Ser Gln Val Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser            
1095                 1100                 1105                            

gca  tct cag gcc gac tgg  cgg cag cag tgg aaa  gcg gaa ccc cag        3566
Ala  Ser Gln Ala Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln            
1110                 1115                 1120                            

gcc  cca ggg tgc ggt gag  acc cca gag gac agt  tgc tcc gag ggc        3611
Ala  Pro Gly Cys Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly            
1125                 1130                 1135                            

agc  aca gca gac atg acc  aac acc gct gag ctc  ctg gag cag atc        3656
Ser  Thr Ala Asp Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile            
1140                 1145                 1150                            

cct  gac ctc ggc cag gat  gtc aag gac cca gag  gac tgc ttc act        3701
Pro  Asp Leu Gly Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr            
1155                 1160                 1165                            

gaa  ggc tgt gtc cgg cgc  tgt ccc tgc tgt gcg  gtg gac acc aca        3746
Glu  Gly Cys Val Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr            
1170                 1175                 1180                            

cag  gcc cca ggg aag gtc  tgg tgg cgg ttg cgc  aag acc tgc tac        3791
Gln  Ala Pro Gly Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr            
1185                 1190                 1195                            

cac  atc gtg gag cac agc  tgg ttc gag aca ttc  atc atc ttc atg        3836
His  Ile Val Glu His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met            
1200                 1205                 1210                            

atc  cta ctc agc agt gga  gcg ctg gcc ttc gag  gac atc tac cta        3881
Ile  Leu Leu Ser Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu            
1215                 1220                 1225                            

gag  gag cgg aag acc atc  aag gtt ctg ctt gag  tat gcc gac aag        3926
Glu  Glu Arg Lys Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys            
1230                 1235                 1240                            

atg  ttc aca tat gtc ttc  gtg ctg gag atg ctg  ctc aag tgg gtg        3971
Met  Phe Thr Tyr Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val            
1245                 1250                 1255                            

gcc  tac ggc ttc aag aag  tac ttc acc aat gcc  tgg tgc tgg ctc        4016
Ala  Tyr Gly Phe Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu            
1260                 1265                 1270                            

gac  ttc ctc atc gta gac  gtc tct ctg gtc agc  ctg gtg gcc aac        4061
Asp  Phe Leu Ile Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn            
1275                 1280                 1285                            

acc  ctg ggc ttt gcc gag  atg ggc ccc atc aag  tca ctg cgg acg        4106
Thr  Leu Gly Phe Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr            
1290                 1295                 1300                            

ctg  cgt gca ctc cgt cct  ctg aga gct ctg tca  cga ttt gag ggc        4151
Leu  Arg Ala Leu Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly            
1305                 1310                 1315                            

atg  agg gtg gtg gtc aat  gcc ctg gtg ggc gcc  atc ccg tcc atc        4196
Met  Arg Val Val Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile            
1320                 1325                 1330                            

atg  aac gtc ctc ctc gtc  tgc ctc atc ttc tgg  ctc atc ttc agc        4241
Met  Asn Val Leu Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser            
1335                 1340                 1345                            

atc  atg ggc gtg aac ctc  ttt gcg ggg aag ttt  ggg agg tgc atc        4286
Ile  Met Gly Val Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile            
1350                 1355                 1360                            

aac  cag aca gag gga gac  ttg cct ttg aac tac  acc atc gtg aac        4331
Asn  Gln Thr Glu Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn            
1365                 1370                 1375                            

aac  aag agc cag tgt gag  tcc ttg aac ttg acc  gga gaa ttg tac        4376
Asn  Lys Ser Gln Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr            
1380                 1385                 1390                            

tgg  acc aag gtg aaa gtc  aac ttt gac aac gtg  ggg gcc ggg tac        4421
Trp  Thr Lys Val Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr            
1395                 1400                 1405                            

ctg  gcc ctt ctg cag gtg  gca aca ttt aaa ggc  tgg atg gac att        4466
Leu  Ala Leu Leu Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile            
1410                 1415                 1420                            

atg  tat gca gct gtg gac  tcc agg ggg tat gaa  gag cag cct cag        4511
Met  Tyr Ala Ala Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln            
1425                 1430                 1435                            

tgg  gaa tac aac ctc tac  atg tac atc tat ttt  gtc att ttc atc        4556
Trp  Glu Tyr Asn Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile            
1440                 1445                 1450                            

atc  ttt ggg tct ttc ttc  acc ctg aac ctc ttt  att ggt gtc atc        4601
Ile  Phe Gly Ser Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile            
1455                 1460                 1465                            

att  gac aac ttc aac caa  cag aag aaa aag tta  ggg ggc cag gac        4646
Ile  Asp Asn Phe Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp            
1470                 1475                 1480                            

atc  ttc atg aca gag gag  cag aag aag tac tac  aat gcc atg aag        4691
Ile  Phe Met Thr Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys            
1485                 1490                 1495                            

aag  ctg ggc tcc aag aag  ccc cag aag ccc atc  cca cgg ccc ctg        4736
Lys  Leu Gly Ser Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu            
1500                 1505                 1510                            

aac  aag tac cag ggc ttc  ata ttc gac att gtg  acc aag cag gcc        4781
Asn  Lys Tyr Gln Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala            
1515                 1520                 1525                            

ttt  gac gtc acc atc atg  ttt ctg atc tgc ttg  aat atg gtg acc        4826
Phe  Asp Val Thr Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr            
1530                 1535                 1540                            

atg  atg gtg gag aca gat  gac caa agt cct gag  aaa atc aac atc        4871
Met  Met Val Glu Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile            
1545                 1550                 1555                            

ttg  gcc aag atc aac ctg  ctc ttt gtg gcc atc  ttc aca ggc gag        4916
Leu  Ala Lys Ile Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu            
1560                 1565                 1570                            

tgt  att gtc aag ctg gct  gcc ctg cgc cac tac  tac ttc acc aac        4961
Cys  Ile Val Lys Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn            
1575                 1580                 1585                            

agc  tgg aat atc ttc gac  ttc gtg gtt gtc atc  ctc tcc atc gtg        5006
Ser  Trp Asn Ile Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val            
1590                 1595                 1600                            

ggc  act gtg ctc tcg gac  atc atc cag aag tac  ttc ttc tcc ccg        5051
Gly  Thr Val Leu Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro            
1605                 1610                 1615                            

acg  ctc ttc cga gtc atc  cgc ctg gcc cga ata  ggc cgc atc ctc        5096
Thr  Leu Phe Arg Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu            
1620                 1625                 1630                            

aga  ctg atc cga ggg gcc  aag ggg atc cgc acg  ctg ctc ttt gcc        5141
Arg  Leu Ile Arg Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala            
1635                 1640                 1645                            

ctc  atg atg tcc ctg cct  gcc ctc ttc aac atc  ggg ctg ctg ctc        5186
Leu  Met Met Ser Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu            
1650                 1655                 1660                            

ttc  ctc gtc atg ttc atc  tac tcc atc ttt ggc  atg gcc aac ttc        5231
Phe  Leu Val Met Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe            
1665                 1670                 1675                            

gct  tat gtc aag tgg gag  gct ggc atc gac gac  atg ttc aac ttc        5276
Ala  Tyr Val Lys Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe            
1680                 1685                 1690                            

cag  acc ttc gcc aac agc  atg ctg tgc ctc ttc  cag atc acc acg        5321
Gln  Thr Phe Ala Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr            
1695                 1700                 1705                            

tcg  gcc ggc tgg gat ggc  ctc ctc agc ccc atc  ctc aac act ggg        5366
Ser  Ala Gly Trp Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly            
1710                 1715                 1720                            

ccg  ccc tac tgc gac ccc  act ctg ccc aac agc  aat ggc tct cgg        5411
Pro  Pro Tyr Cys Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg            
1725                 1730                 1735                            

ggg  gac tgc ggg agc cca  gcc gtg ggc atc ctc  ttc ttc acc acc        5456
Gly  Asp Cys Gly Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr            
1740                 1745                 1750                            

tac  atc atc atc tcc ttc  ctc atc gtg gtc aac  atg tac att gcc        5501
Tyr  Ile Ile Ile Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala            
1755                 1760                 1765                            

atc  atc ctg gag aac ttc  agc gtg gcc acg gag  gag agc acc gag        5546
Ile  Ile Leu Glu Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu            
1770                 1775                 1780                            

ccc  ctg agt gag gac gac  ttc gat atg ttc tat  gag atc tgg gag        5591
Pro  Leu Ser Glu Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu            
1785                 1790                 1795                            

aaa  ttt gac cca gag gcc  act cag ttt att gag  tat tcg gtc ctg        5636
Lys  Phe Asp Pro Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu            
1800                 1805                 1810                            

tct  gac ttt gcc gat gcc  ctg tct gag cca ctc  cgt atc gcc aag        5681
Ser  Asp Phe Ala Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys            
1815                 1820                 1825                            

ccc  aac cag ata agc ctc  atc aac atg gac ctg  ccc atg gtg agt        5726
Pro  Asn Gln Ile Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser            
1830                 1835                 1840                            

ggg  gac cgc atc cat tgc  atg gac att ctc ttt  gcc ttc acc aaa        5771
Gly  Asp Arg Ile His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys            
1845                 1850                 1855                            

agg  gtc ctg ggg gag tct  ggg gag atg gac gcc  ctg aag atc cag        5816
Arg  Val Leu Gly Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln            
1860                 1865                 1870                            

atg  gag gag aag ttc atg  gca gcc aac cca tcc  aag atc tcc tac        5861
Met  Glu Glu Lys Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr            
1875                 1880                 1885                            

gag  ccc atc acc acc aca  ctc cgg cgc aag cac  gaa gag gtg tcg        5906
Glu  Pro Ile Thr Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser            
1890                 1895                 1900                            

gcc  atg gtt atc cag aga  gcc ttc cgc agg cac  ctg ctg caa cgc        5951
Ala  Met Val Ile Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg            
1905                 1910                 1915                            

tct  ttg aag cat gcc tcc  ttc ctc ttc cgt cag  cag gcg ggc agc        5996
Ser  Leu Lys His Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser            
1920                 1925                 1930                            

ggc  ctc tcc gaa gag gat  gcc cct gag cga gag  ggc ctc atc gcc        6041
Gly  Leu Ser Glu Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala            
1935                 1940                 1945                            

tac  gtg atg agt gag aac  ttc tcc cga ccc ctt  ggc cca ccc tcc        6086
Tyr  Val Met Ser Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser            
1950                 1955                 1960                            

agc  tcc tcc atc tcc tcc  act tcc ttc cca ccc  tcc tat gac agt        6131
Ser  Ser Ser Ile Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser            
1965                 1970                 1975                            

gtc  act aga gcc acc agc  gat aac ctc cag gtg  cgg ggg tct gac        6176
Val  Thr Arg Ala Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp            
1980                 1985                 1990                            

tac  agc cac agt gaa gat  ctc gcc gac ttc ccc  cct tct ccg gac        6221
Tyr  Ser His Ser Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp            
1995                 2000                 2005                            

agg  gac cgt gag tcc atc  gtg tga gcctcggcct ggctggccag               6265
Arg  Asp Arg Glu Ser Ile  Val                                             
2010                 2015                                                 

gacacactga aaagcagcct ttttcaccat ggcaaaccta aatgcagtca gtcacaaacc     6325

agcctggggc cttcctggct ttgggagtaa gaaatgggcc tcagccccgc ggatcaacca     6385

ggcagagttc tgtggcgccg cgtggacagc cggagcagtt ggcctgtgct tggaggcctc     6445

agatagacct gtgacctggt ctggtcaggc aatgccctgc ggctctggaa agcaacttca     6505

tcccagctgc tgaggcgaaa tataaaactg agactgtata tgttgtgaat gggctttcat     6565

aaatttatta tatttgatat ttttttactt gagcaaagaa ctaaggattt ttccatggac     6625

atgggcagca attcacgctg tctcttctta accctgaaca agagtgtcta tggagcagcc     6685

ggaagtctgt tctcaaagca gaagtggaat ccagtgtggc tcccacaggt cttcactgcc     6745

caggggtcga atggggtccc cctcccactt gacctgagat gctgggaggg ctgaaccccc     6805

actcacacaa gcacacacac acagtcctca cacacggagg ccagacacag gccgtgggac     6865

ccaggctccc agcctaaggg agacaggcct ttccctgccg gccccccaag gatggggttc     6925

ttgtccacgg ggctcactct ggccccctat tgtctccaag gtcccatttt ccccctgtgt     6985

tttcacgcag gtcatattgt cagtcctaca aaaataaaag gcttccagag gagagtggcc     7045

tgggtcccag ggctggccct aggcactgat agttgccttt tcttcccctc ctgtaagagt     7105

attaacaaaa ccaaaggaca caagggtgca agccccattc acggcctggc atgcagcttg     7165

tccttgctcc tggaacctgg caggccctgc ccagccagcc atcggaagag agggctgagc     7225

catgggggtt tggggctaag aagttcacca gccctgagcc atggcggccc ctcagcctgc     7285

ctgaagagag gaaactggcg atctcccagg gctctctgga ccatacgcgg aggagttttc     7345

tgtgtggtct ccagctcctc tccagacaca gagacatggg agtggggagc ggagcttggc     7405

cctgcgccct gtgcagggaa agggatggtc aggcccagtt ctcgtgccct tagaggggaa     7465

tgaaccatgg cacctttgag agagggggca ctgtggtcag gcccagcctc tctggctcag     7525

cccgggatcc tgatggcacc cacacagagg acctctttgg ggcaagatcc aggtggtccc     7585

ataggtcttg tgaaaaggct ttttcaggga aaaatatttt actagtccaa tcacccccag     7645

gacctcttca gctgctgaca atcctattta gcatatgcaa atcttttaac atagagaact     7705

gtcaccctga ggtaacaggg tcaactggcg aagcctgagc aggcaggggc ttggctgccc     7765

cattccagct ctcccatgga gcccctccac cgggcgcatg cctcccaggc cacctcagtc     7825

tcacctgccg gctctgggct ggctgctcct aacctacctc gccgagctgt cggagggctg     7885

gacatttgtg gcagtgctga agggggcatt gccggcgagt aaagtattat gtttcttctt     7945

gtcaccccag ttcccttggt ggcaacccca gacccaaccc atgcccctga cagatctagt     8005

tctcttctcc tgtgttccct ttgagtccag tgtgggacac ggtttaactg tcccagcgac     8065

atttctccaa gtggaaatcc tatttttgta gatctccatg ctttgctctc aaggcttgga     8125

gaggtatgtg cccctcctgg gtgctcaccg cctgctacac aggcaggaat gcggttggga     8185

ggcaggtcgg gctgccagcc cagctggccg gaaggagact gtggtttttg tgtgtgtgga     8245

cagcccggga gctttgagac aggtgcctgg ggctggctgc agacggtgtg gttgggggtg     8305

ggaggtgagc tagacccaac ccttagcttt tagcctggct gtcacctttt taatttccag     8365

aactgcacaa tgaccagcag gagggaagga cagacatcaa gtgccagatg ttgtctgaac     8425

taatcgagca cttctcacca aacttcatgt ataaataaaa tacatatttt taaaacaaac     8485

caataaatgg cttacatga                                                  8504


<210>  7
<211>  2016
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Thr Val Leu 
    1595                 1600                 1605             


Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro Thr  Leu Phe Arg 
    1610                 1615                 1620             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg 
    1625                 1630                 1635             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1640                 1645                 1650             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1655                 1660                 1665             


Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe Ala  Tyr Val Lys 
    1670                 1675                 1680             


Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala 
    1685                 1690                 1695             


Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1700                 1705                 1710             


Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys 
    1715                 1720                 1725             


Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg Gly  Asp Cys Gly 
    1730                 1735                 1740             


Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr Tyr  Ile Ile Ile 
    1745                 1750                 1755             


Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala Ile  Ile Leu Glu 
    1760                 1765                 1770             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1775                 1780                 1785             


Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu Lys  Phe Asp Pro 
    1790                 1795                 1800             


Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu Ser  Asp Phe Ala 
    1805                 1810                 1815             


Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys Pro  Asn Gln Ile 
    1820                 1825                 1830             


Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1835                 1840                 1845             


His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1850                 1855                 1860             


Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln Met  Glu Glu Lys 
    1865                 1870                 1875             


Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr Glu  Pro Ile Thr 
    1880                 1885                 1890             


Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser Ala  Met Val Ile 
    1895                 1900                 1905             


Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg Ser  Leu Lys His 
    1910                 1915                 1920             


Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser Gly  Leu Ser Glu 
    1925                 1930                 1935             


Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala Tyr  Val Met Ser 
    1940                 1945                 1950             


Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser Ser  Ser Ser Ile 
    1955                 1960                 1965             


Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser Val  Thr Arg Ala 
    1970                 1975                 1980             


Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp Tyr  Ser His Ser 
    1985                 1990                 1995             


Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp Arg  Asp Arg Glu 
    2000                 2005                 2010             


Ser Ile  Val 
    2015     


<210>  8
<211>  8501
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (195)..(6242)

<400>  8
agacggcggc ggcgcccgta ggatgcaggg atcgctcccc cggggccgct gagcctgcgc       60

ccagtgcccc gagccccgcg ccgagccgag tccgcgccaa gcagcagccg cccaccccgg      120

ggcccggccg ggggaccagc agcttcccca caggcaacgt gaggagagcc tgtgcccaga      180

agcaggatga gaag atg gca aac ttc cta tta cct cgg ggc acc agc agc        230
                Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser           
                1               5                   10                    

ttc cgc agg ttc aca cgg gag tcc ctg gca gcc atc gag aag cgc atg        278
Phe Arg Arg Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met           
        15                  20                  25                        

gca gag aag caa gcc cgc ggc tca acc acc ttg cag gag agc cga gag        326
Ala Glu Lys Gln Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu           
    30                  35                  40                            

ggg ctg ccc gag gag gag gct ccc cgg ccc cag ctg gac ctg cag gcc        374
Gly Leu Pro Glu Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala           
45                  50                  55                  60            

tcc aaa aag ctg cca gat ctc tat ggc aat cca ccc caa gag ctc atc        422
Ser Lys Lys Leu Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile           
                65                  70                  75                

gga gag ccc ctg gag gac ctg gac ccc ttc tat agc acc caa aag act        470
Gly Glu Pro Leu Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr           
            80                  85                  90                    

ttc atc gta ctg aat aaa ggc aag acc atc ttc cgg ttc agt gcc acc        518
Phe Ile Val Leu Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr           
        95                  100                 105                       

aac gcc ttg tat gtc ctc agt ccc ttc cac ccc atc cgg aga gcg gct        566
Asn Ala Leu Tyr Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala           
    110                 115                 120                           

gtg aag att ctg gtt cac tcg ctc ttc aac atg ctc atc atg tgc acc        614
Val Lys Ile Leu Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr           
125                 130                 135                 140           

atc ctc acc aac tgc gtg ttc atg gcc cag cac gac cct cca ccc tgg        662
Ile Leu Thr Asn Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp           
                145                 150                 155               

acc aag tat gtc gag tac acc ttc acc gcc att tac acc ttt gag tct        710
Thr Lys Tyr Val Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser           
            160                 165                 170                   

ctg gtc aag att ctg gct cga ggc ttc tgc ctg cac gcg ttc act ttc        758
Leu Val Lys Ile Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe           
        175                 180                 185                       

ctt cgg gac cca tgg aac tgg ctg gac ttt agt gtg att atc atg gca        806
Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala           
    190                 195                 200                           

tac aca act gaa ttt gtg gac ctg ggc aat gtc tca gcc tta cgc acc        854
Tyr Thr Thr Glu Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr           
205                 210                 215                 220           

ttc cga gtc ctc cgg gcc ctg aaa act ata tca gtc att tca ggg ctg        902
Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu           
                225                 230                 235               

aag acc atc gtg ggg gcc ctg atc cag tct gtg aag aag ctg gct gat        950
Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp           
            240                 245                 250                   

gtg atg gtc ctc aca gtc ttc tgc ctc agc gtc ttt gcc ctc atc ggc        998
Val Met Val Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly           
        255                 260                 265                       

ctg cag ctc ttc atg ggc aac cta agg cac aag tgc gtg cgc aac ttc       1046
Leu Gln Leu Phe Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe           
    270                 275                 280                           

aca gcg ctc aac ggc acc aac ggc tcc gtg gag gcc gac ggc ttg gtc       1094
Thr Ala Leu Asn Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val           
285                 290                 295                 300           

tgg gaa tcc ctg gac ctt tac ctc agt gat cca gaa aat tac ctg ctc       1142
Trp Glu Ser Leu Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu           
                305                 310                 315               

aag aac ggc acc tct gat gtg tta ctg tgt ggg aac agc tct gac gct       1190
Lys Asn Gly Thr Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala           
            320                 325                 330                   

ggg aca tgt ccg gag ggc tac cgg tgc cta aag gca ggc gag aac ccc       1238
Gly Thr Cys Pro Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro           
        335                 340                 345                       

gac cac ggc tac acc agc ttc gat tcc ttt gcc tgg gcc ttt ctt gca       1286
Asp His Gly Tyr Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala           
    350                 355                 360                           

ctc ttc cgc ctg atg acg cag gac tgc tgg gag cgc ctc tat cag cag       1334
Leu Phe Arg Leu Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln           
365                 370                 375                 380           

acc ctc agg tcc gca ggg aag atc tac atg atc ttc ttc atg ctt gtc       1382
Thr Leu Arg Ser Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val           
                385                 390                 395               

atc ttc ctg ggg tcc ttc tac ctg gtg aac ctg atc ctg gcc gtg gtc       1430
Ile Phe Leu Gly Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val           
            400                 405                 410                   

gca atg gcc tat gag gag caa aac caa gcc acc atc gct gag acc gag       1478
Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu           
        415                 420                 425                       

gag aag gaa aag cgc ttc cag gag gcc atg gaa atg ctc aag aaa gaa       1526
Glu Lys Glu Lys Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu           
    430                 435                 440                           

cac gag gcc ctc acc atc agg ggt gtg gat acc gtg tcc cgt agc tcc       1574
His Glu Ala Leu Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser           
445                 450                 455                 460           

ttg gag atg tcc cct ttg gcc cca gta aac agc cat gag aga aga agc       1622
Leu Glu Met Ser Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser           
                465                 470                 475               

aag agg aga aaa cgg atg tct tca gga act gag gag tgt ggg gag gac       1670
Lys Arg Arg Lys Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp           
            480                 485                 490                   

agg ctc ccc aag tct gac tca gaa gat ggt ccc aga gca atg aat cat       1718
Arg Leu Pro Lys Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His           
        495                 500                 505                       

ctc agc ctc acc cgt ggc ctc agc agg act tct atg aag cca cgt tcc       1766
Leu Ser Leu Thr Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser           
    510                 515                 520                           

agc cgc ggg agc att ttc acc ttt cgc agg cga gac ctg ggt tct gaa       1814
Ser Arg Gly Ser Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu           
525                 530                 535                 540           

gca gat ttt gca gat gat gaa aac agc aca gcg ggg gag agc gag agc       1862
Ala Asp Phe Ala Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser           
                545                 550                 555               

cac cac aca tca ctg ctg gtg ccc tgg ccc ctg cgc cgg acc agt gcc       1910
His His Thr Ser Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala           
            560                 565                 570                   

cag gga cag ccc agt ccc gga acc tcg gct cct ggc cac gcc ctc cat       1958
Gln Gly Gln Pro Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His           
        575                 580                 585                       

ggc aaa aag aac agc act gtg gac tgc aat ggg gtg gtc tca tta ctg       2006
Gly Lys Lys Asn Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu           
    590                 595                 600                           

ggg gca ggc gac cca gag gcc aca tcc cca gga agc cac ctc ctc cgc       2054
Gly Ala Gly Asp Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg           
605                 610                 615                 620           

cct gtg atg cta gag cac ccg cca gac acg acc acg cca tcg gag gag       2102
Pro Val Met Leu Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu           
                625                 630                 635               

cca ggc ggg ccc cag atg ctg acc tcc cag gct ccg tgt gta gat ggc       2150
Pro Gly Gly Pro Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly           
            640                 645                 650                   

ttc gag gag cca gga gca cgg cag cgg gcc ctc agc gca gtc agc gtc       2198
Phe Glu Glu Pro Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val           
        655                 660                 665                       

ctc acc agc gca ctg gaa gag tta gag gag tct cgc cac aag tgt cca       2246
Leu Thr Ser Ala Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro           
    670                 675                 680                           

cca tgc tgg aac cgt ctc gcc cag cgc tac ctg atc tgg gag tgc tgc       2294
Pro Cys Trp Asn Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys           
685                 690                 695                 700           

ccg ctg tgg atg tcc atc aag cag gga gtg aag ttg gtg gtc atg gac       2342
Pro Leu Trp Met Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp           
                705                 710                 715               

ccg ttt act gac ctc acc atc act atg tgc atc gta ctc aac aca ctc       2390
Pro Phe Thr Asp Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu           
            720                 725                 730                   

ttc atg gcg ctg gag cac tac aac atg aca agt gaa ttc gag gag atg       2438
Phe Met Ala Leu Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met           
        735                 740                 745                       

ctg cag gtc gga aac ctg gtc ttc aca ggg att ttc aca gca gag atg       2486
Leu Gln Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met           
    750                 755                 760                           

acc ttc aag atc att gcc ctc gac ccc tac tac tac ttc caa cag ggc       2534
Thr Phe Lys Ile Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly           
765                 770                 775                 780           

tgg aac atc ttc gac agc atc atc gtc atc ctt agc ctc atg gag ctg       2582
Trp Asn Ile Phe Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu           
                785                 790                 795               

ggc ctg tcc cgc atg agc aac ttg tcg gtg ctg cgc tcc ttc cgc ctg       2630
Gly Leu Ser Arg Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu           
            800                 805                 810                   

ctg cgg gtc ttc aag ctg gcc aaa tca tgg ccc acc ctg aac aca ctc       2678
Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu           
        815                 820                 825                       

atc aag atc atc ggg aac tca gtg ggg gca ctg ggg aac ctg aca ctg       2726
Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu           
    830                 835                 840                           

gtg cta gcc atc atc gtg ttc atc ttt gct gtg gtg ggc atg cag ctc       2774
Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu           
845                 850                 855                 860           

ttt ggc aag aac tac tcg gag ctg agg gac agc gac tca ggc ctg ctg       2822
Phe Gly Lys Asn Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu           
                865                 870                 875               

cct cgc tgg cac atg atg gac ttc ttt cat gcc ttc ctc atc atc ttc       2870
Pro Arg Trp His Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe           
            880                 885                 890                   

cgc atc ctc tgt gga gag tgg atc gag acc atg tgg gac tgc atg gag       2918
Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu           
        895                 900                 905                       

gtg tcg ggg cag tca tta tgc ctg ctg gtc ttc ttg ctt gtt atg gtc       2966
Val Ser Gly Gln Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val           
    910                 915                 920                           

att ggc aac ctt gtg gtc ctg aat ctc ttc ctg gcc ttg ctg ctc agc       3014
Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser           
925                 930                 935                 940           

tcc ttc agt gca gac aac ctc aca gcc cct gat gag gac aga gag atg       3062
Ser Phe Ser Ala Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met           
                945                 950                 955               

aac aac ctc cag ctg gcc ctg gcc cgc atc cag agg ggc ctg cgc ttt       3110
Asn Asn Leu Gln Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe           
            960                 965                 970                   

gtc aag cgg acc acc tgg gat ttc tgc tgt ggt ctc ctg cgg cag cgg       3158
Val Lys Arg Thr Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg           
        975                 980                 985                       

cct cag aag ccc gca gcc ctt gcc gcc cag ggc cag  ctg ccc agc tgc      3206
Pro Gln Lys Pro Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys          
    990                 995                 1000                          

att  gcc acc ccc tac tcc  ccg cca ccc cca gag  acg gag aag gtg        3251
Ile  Ala Thr Pro Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val            
1005                 1010                 1015                            

cct  ccc acc cgc aag gaa  aca cgg ttt gag gaa  ggc gag caa cca        3296
Pro  Pro Thr Arg Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro            
1020                 1025                 1030                            

ggc  cag ggc acc ccc ggg  gat cca gag ccc gtg  tgt gtg ccc atc        3341
Gly  Gln Gly Thr Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile            
1035                 1040                 1045                            

gct  gtg gcc gag tca gac  aca gat gac caa gaa  gaa gat gag gag        3386
Ala  Val Ala Glu Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu            
1050                 1055                 1060                            

aac  agc ctg ggc acg gag  gag gag tcc agc aag  cag gaa tcc cag        3431
Asn  Ser Leu Gly Thr Glu  Glu Glu Ser Ser Lys  Gln Glu Ser Gln            
1065                 1070                 1075                            

cct  gtg tcc ggt ggc cca  gag gcc cct ccg gat  tcc agg acc tgg        3476
Pro  Val Ser Gly Gly Pro  Glu Ala Pro Pro Asp  Ser Arg Thr Trp            
1080                 1085                 1090                            

agc  cag gtg tca gcg act  gcc tcc tct gag gcc  gag gcc agt gca        3521
Ser  Gln Val Ser Ala Thr  Ala Ser Ser Glu Ala  Glu Ala Ser Ala            
1095                 1100                 1105                            

tct  cag gcc gac tgg cgg  cag cag tgg aaa gcg  gaa ccc cag gcc        3566
Ser  Gln Ala Asp Trp Arg  Gln Gln Trp Lys Ala  Glu Pro Gln Ala            
1110                 1115                 1120                            

cca  ggg tgc ggt gag acc  cca gag gac agt tgc  tcc gag ggc agc        3611
Pro  Gly Cys Gly Glu Thr  Pro Glu Asp Ser Cys  Ser Glu Gly Ser            
1125                 1130                 1135                            

aca  gca gac atg acc aac  acc gct gag ctc ctg  gag cag atc cct        3656
Thr  Ala Asp Met Thr Asn  Thr Ala Glu Leu Leu  Glu Gln Ile Pro            
1140                 1145                 1150                            

gac  ctc ggc cag gat gtc  aag gac cca gag gac  tgc ttc act gaa        3701
Asp  Leu Gly Gln Asp Val  Lys Asp Pro Glu Asp  Cys Phe Thr Glu            
1155                 1160                 1165                            

ggc  tgt gtc cgg cgc tgt  ccc tgc tgt gcg gtg  gac acc aca cag        3746
Gly  Cys Val Arg Arg Cys  Pro Cys Cys Ala Val  Asp Thr Thr Gln            
1170                 1175                 1180                            

gcc  cca ggg aag gtc tgg  tgg cgg ttg cgc aag  acc tgc tac cac        3791
Ala  Pro Gly Lys Val Trp  Trp Arg Leu Arg Lys  Thr Cys Tyr His            
1185                 1190                 1195                            

atc  gtg gag cac agc tgg  ttc gag aca ttc atc  atc ttc atg atc        3836
Ile  Val Glu His Ser Trp  Phe Glu Thr Phe Ile  Ile Phe Met Ile            
1200                 1205                 1210                            

cta  ctc agc agt gga gcg  ctg gcc ttc gag gac  atc tac cta gag        3881
Leu  Leu Ser Ser Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Leu Glu            
1215                 1220                 1225                            

gag  cgg aag acc atc aag  gtt ctg ctt gag tat  gcc gac aag atg        3926
Glu  Arg Lys Thr Ile Lys  Val Leu Leu Glu Tyr  Ala Asp Lys Met            
1230                 1235                 1240                            

ttc  aca tat gtc ttc gtg  ctg gag atg ctg ctc  aag tgg gtg gcc        3971
Phe  Thr Tyr Val Phe Val  Leu Glu Met Leu Leu  Lys Trp Val Ala            
1245                 1250                 1255                            

tac  ggc ttc aag aag tac  ttc acc aat gcc tgg  tgc tgg ctc gac        4016
Tyr  Gly Phe Lys Lys Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu Asp            
1260                 1265                 1270                            

ttc  ctc atc gta gac gtc  tct ctg gtc agc ctg  gtg gcc aac acc        4061
Phe  Leu Ile Val Asp Val  Ser Leu Val Ser Leu  Val Ala Asn Thr            
1275                 1280                 1285                            

ctg  ggc ttt gcc gag atg  ggc ccc atc aag tca  ctg cgg acg ctg        4106
Leu  Gly Phe Ala Glu Met  Gly Pro Ile Lys Ser  Leu Arg Thr Leu            
1290                 1295                 1300                            

cgt  gca ctc cgt cct ctg  aga gct ctg tca cga  ttt gag ggc atg        4151
Arg  Ala Leu Arg Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly Met            
1305                 1310                 1315                            

agg  gtg gtg gtc aat gcc  ctg gtg ggc gcc atc  ccg tcc atc atg        4196
Arg  Val Val Val Asn Ala  Leu Val Gly Ala Ile  Pro Ser Ile Met            
1320                 1325                 1330                            

aac  gtc ctc ctc gtc tgc  ctc atc ttc tgg ctc  atc ttc agc atc        4241
Asn  Val Leu Leu Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser Ile            
1335                 1340                 1345                            

atg  ggc gtg aac ctc ttt  gcg ggg aag ttt ggg  agg tgc atc aac        4286
Met  Gly Val Asn Leu Phe  Ala Gly Lys Phe Gly  Arg Cys Ile Asn            
1350                 1355                 1360                            

cag  aca gag gga gac ttg  cct ttg aac tac acc  atc gtg aac aac        4331
Gln  Thr Glu Gly Asp Leu  Pro Leu Asn Tyr Thr  Ile Val Asn Asn            
1365                 1370                 1375                            

aag  agc cag tgt gag tcc  ttg aac ttg acc gga  gaa ttg tac tgg        4376
Lys  Ser Gln Cys Glu Ser  Leu Asn Leu Thr Gly  Glu Leu Tyr Trp            
1380                 1385                 1390                            

acc  aag gtg aaa gtc aac  ttt gac aac gtg ggg  gcc ggg tac ctg        4421
Thr  Lys Val Lys Val Asn  Phe Asp Asn Val Gly  Ala Gly Tyr Leu            
1395                 1400                 1405                            

gcc  ctt ctg cag gtg gca  aca ttt aaa ggc tgg  atg gac att atg        4466
Ala  Leu Leu Gln Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile Met            
1410                 1415                 1420                            

tat  gca gct gtg gac tcc  agg ggg tat gaa gag  cag cct cag tgg        4511
Tyr  Ala Ala Val Asp Ser  Arg Gly Tyr Glu Glu  Gln Pro Gln Trp            
1425                 1430                 1435                            

gaa  tac aac ctc tac atg  tac atc tat ttt gtc  att ttc atc atc        4556
Glu  Tyr Asn Leu Tyr Met  Tyr Ile Tyr Phe Val  Ile Phe Ile Ile            
1440                 1445                 1450                            

ttt  ggg tct ttc ttc acc  ctg aac ctc ttt att  ggt gtc atc att        4601
Phe  Gly Ser Phe Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile Ile            
1455                 1460                 1465                            

gac  aac ttc aac caa cag  aag aaa aag tta ggg  ggc cag gac atc        4646
Asp  Asn Phe Asn Gln Gln  Lys Lys Lys Leu Gly  Gly Gln Asp Ile            
1470                 1475                 1480                            

ttc  atg aca gag gag cag  aag aag tac tac aat  gcc atg aag aag        4691
Phe  Met Thr Glu Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys Lys            
1485                 1490                 1495                            

ctg  ggc tcc aag aag ccc  cag aag ccc atc cca  cgg ccc ctg aac        4736
Leu  Gly Ser Lys Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Leu Asn            
1500                 1505                 1510                            

aag  tac cag ggc ttc ata  ttc gac att gtg acc  aag cag gcc ttt        4781
Lys  Tyr Gln Gly Phe Ile  Phe Asp Ile Val Thr  Lys Gln Ala Phe            
1515                 1520                 1525                            

gac  gtc acc atc atg ttt  ctg atc tgc ttg aat  atg gtg acc atg        4826
Asp  Val Thr Ile Met Phe  Leu Ile Cys Leu Asn  Met Val Thr Met            
1530                 1535                 1540                            

atg  gtg gag aca gat gac  caa agt cct gag aaa  atc aac atc ttg        4871
Met  Val Glu Thr Asp Asp  Gln Ser Pro Glu Lys  Ile Asn Ile Leu            
1545                 1550                 1555                            

gcc  aag atc aac ctg ctc  ttt gtg gcc atc ttc  aca ggc gag tgt        4916
Ala  Lys Ile Asn Leu Leu  Phe Val Ala Ile Phe  Thr Gly Glu Cys            
1560                 1565                 1570                            

att  gtc aag ctg gct gcc  ctg cgc cac tac tac  ttc acc aac agc        4961
Ile  Val Lys Leu Ala Ala  Leu Arg His Tyr Tyr  Phe Thr Asn Ser            
1575                 1580                 1585                            

tgg  aat atc ttc gac ttc  gtg gtt gtc atc ctc  tcc atc gtg ggc        5006
Trp  Asn Ile Phe Asp Phe  Val Val Val Ile Leu  Ser Ile Val Gly            
1590                 1595                 1600                            

act  gtg ctc tcg gac atc  atc cag aag tac ttc  ttc tcc ccg acg        5051
Thr  Val Leu Ser Asp Ile  Ile Gln Lys Tyr Phe  Phe Ser Pro Thr            
1605                 1610                 1615                            

ctc  ttc cga gtc atc cgc  ctg gcc cga ata ggc  cgc atc ctc aga        5096
Leu  Phe Arg Val Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu Arg            
1620                 1625                 1630                            

ctg  atc cga ggg gcc aag  ggg atc cgc acg ctg  ctc ttt gcc ctc        5141
Leu  Ile Arg Gly Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala Leu            
1635                 1640                 1645                            

atg  atg tcc ctg cct gcc  ctc ttc aac atc ggg  ctg ctg ctc ttc        5186
Met  Met Ser Leu Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu Phe            
1650                 1655                 1660                            

ctc  gtc atg ttc atc tac  tcc atc ttt ggc atg  gcc aac ttc gct        5231
Leu  Val Met Phe Ile Tyr  Ser Ile Phe Gly Met  Ala Asn Phe Ala            
1665                 1670                 1675                            

tat  gtc aag tgg gag gct  ggc atc gac gac atg  ttc aac ttc cag        5276
Tyr  Val Lys Trp Glu Ala  Gly Ile Asp Asp Met  Phe Asn Phe Gln            
1680                 1685                 1690                            

acc  ttc gcc aac agc atg  ctg tgc ctc ttc cag  atc acc acg tcg        5321
Thr  Phe Ala Asn Ser Met  Leu Cys Leu Phe Gln  Ile Thr Thr Ser            
1695                 1700                 1705                            

gcc  ggc tgg gat ggc ctc  ctc agc ccc atc ctc  aac act ggg ccg        5366
Ala  Gly Trp Asp Gly Leu  Leu Ser Pro Ile Leu  Asn Thr Gly Pro            
1710                 1715                 1720                            

ccc  tac tgc gac ccc act  ctg ccc aac agc aat  ggc tct cgg ggg        5411
Pro  Tyr Cys Asp Pro Thr  Leu Pro Asn Ser Asn  Gly Ser Arg Gly            
1725                 1730                 1735                            

gac  tgc ggg agc cca gcc  gtg ggc atc ctc ttc  ttc acc acc tac        5456
Asp  Cys Gly Ser Pro Ala  Val Gly Ile Leu Phe  Phe Thr Thr Tyr            
1740                 1745                 1750                            

atc  atc atc tcc ttc ctc  atc gtg gtc aac atg  tac att gcc atc        5501
Ile  Ile Ile Ser Phe Leu  Ile Val Val Asn Met  Tyr Ile Ala Ile            
1755                 1760                 1765                            

atc  ctg gag aac ttc agc  gtg gcc acg gag gag  agc acc gag ccc        5546
Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Thr Glu Pro            
1770                 1775                 1780                            

ctg  agt gag gac gac ttc  gat atg ttc tat gag  atc tgg gag aaa        5591
Leu  Ser Glu Asp Asp Phe  Asp Met Phe Tyr Glu  Ile Trp Glu Lys            
1785                 1790                 1795                            

ttt  gac cca gag gcc act  cag ttt att gag tat  tcg gtc ctg tct        5636
Phe  Asp Pro Glu Ala Thr  Gln Phe Ile Glu Tyr  Ser Val Leu Ser            
1800                 1805                 1810                            

gac  ttt gcc gat gcc ctg  tct gag cca ctc cgt  atc gcc aag ccc        5681
Asp  Phe Ala Asp Ala Leu  Ser Glu Pro Leu Arg  Ile Ala Lys Pro            
1815                 1820                 1825                            

aac  cag ata agc ctc atc  aac atg gac ctg ccc  atg gtg agt ggg        5726
Asn  Gln Ile Ser Leu Ile  Asn Met Asp Leu Pro  Met Val Ser Gly            
1830                 1835                 1840                            

gac  cgc atc cat tgc atg  gac att ctc ttt gcc  ttc acc aaa agg        5771
Asp  Arg Ile His Cys Met  Asp Ile Leu Phe Ala  Phe Thr Lys Arg            
1845                 1850                 1855                            

gtc  ctg ggg gag tct ggg  gag atg gac gcc ctg  aag atc cag atg        5816
Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Lys Ile Gln Met            
1860                 1865                 1870                            

gag  gag aag ttc atg gca  gcc aac cca tcc aag  atc tcc tac gag        5861
Glu  Glu Lys Phe Met Ala  Ala Asn Pro Ser Lys  Ile Ser Tyr Glu            
1875                 1880                 1885                            

ccc  atc acc acc aca ctc  cgg cgc aag cac gaa  gag gtg tcg gcc        5906
Pro  Ile Thr Thr Thr Leu  Arg Arg Lys His Glu  Glu Val Ser Ala            
1890                 1895                 1900                            

atg  gtt atc cag aga gcc  ttc cgc agg cac ctg  ctg caa cgc tct        5951
Met  Val Ile Gln Arg Ala  Phe Arg Arg His Leu  Leu Gln Arg Ser            
1905                 1910                 1915                            

ttg  aag cat gcc tcc ttc  ctc ttc cgt cag cag  gcg ggc agc ggc        5996
Leu  Lys His Ala Ser Phe  Leu Phe Arg Gln Gln  Ala Gly Ser Gly            
1920                 1925                 1930                            

ctc  tcc gaa gag gat gcc  cct gag cga gag ggc  ctc atc gcc tac        6041
Leu  Ser Glu Glu Asp Ala  Pro Glu Arg Glu Gly  Leu Ile Ala Tyr            
1935                 1940                 1945                            

gtg  atg agt gag aac ttc  tcc cga ccc ctt ggc  cca ccc tcc agc        6086
Val  Met Ser Glu Asn Phe  Ser Arg Pro Leu Gly  Pro Pro Ser Ser            
1950                 1955                 1960                            

tcc  tcc atc tcc tcc act  tcc ttc cca ccc tcc  tat gac agt gtc        6131
Ser  Ser Ile Ser Ser Thr  Ser Phe Pro Pro Ser  Tyr Asp Ser Val            
1965                 1970                 1975                            

act  aga gcc acc agc gat  aac ctc cag gtg cgg  ggg tct gac tac        6176
Thr  Arg Ala Thr Ser Asp  Asn Leu Gln Val Arg  Gly Ser Asp Tyr            
1980                 1985                 1990                            

agc  cac agt gaa gat ctc  gcc gac ttc ccc cct  tct ccg gac agg        6221
Ser  His Ser Glu Asp Leu  Ala Asp Phe Pro Pro  Ser Pro Asp Arg            
1995                 2000                 2005                            

gac  cgt gag tcc atc gtg  tga gcctcggcct ggctggccag gacacactga        6272
Asp  Arg Glu Ser Ile Val                                                  
2010                 2015                                                 

aaagcagcct ttttcaccat ggcaaaccta aatgcagtca gtcacaaacc agcctggggc     6332

cttcctggct ttgggagtaa gaaatgggcc tcagccccgc ggatcaacca ggcagagttc     6392

tgtggcgccg cgtggacagc cggagcagtt ggcctgtgct tggaggcctc agatagacct     6452

gtgacctggt ctggtcaggc aatgccctgc ggctctggaa agcaacttca tcccagctgc     6512

tgaggcgaaa tataaaactg agactgtata tgttgtgaat gggctttcat aaatttatta     6572

tatttgatat ttttttactt gagcaaagaa ctaaggattt ttccatggac atgggcagca     6632

attcacgctg tctcttctta accctgaaca agagtgtcta tggagcagcc ggaagtctgt     6692

tctcaaagca gaagtggaat ccagtgtggc tcccacaggt cttcactgcc caggggtcga     6752

atggggtccc cctcccactt gacctgagat gctgggaggg ctgaaccccc actcacacaa     6812

gcacacacac acagtcctca cacacggagg ccagacacag gccgtgggac ccaggctccc     6872

agcctaaggg agacaggcct ttccctgccg gccccccaag gatggggttc ttgtccacgg     6932

ggctcactct ggccccctat tgtctccaag gtcccatttt ccccctgtgt tttcacgcag     6992

gtcatattgt cagtcctaca aaaataaaag gcttccagag gagagtggcc tgggtcccag     7052

ggctggccct aggcactgat agttgccttt tcttcccctc ctgtaagagt attaacaaaa     7112

ccaaaggaca caagggtgca agccccattc acggcctggc atgcagcttg tccttgctcc     7172

tggaacctgg caggccctgc ccagccagcc atcggaagag agggctgagc catgggggtt     7232

tggggctaag aagttcacca gccctgagcc atggcggccc ctcagcctgc ctgaagagag     7292

gaaactggcg atctcccagg gctctctgga ccatacgcgg aggagttttc tgtgtggtct     7352

ccagctcctc tccagacaca gagacatggg agtggggagc ggagcttggc cctgcgccct     7412

gtgcagggaa agggatggtc aggcccagtt ctcgtgccct tagaggggaa tgaaccatgg     7472

cacctttgag agagggggca ctgtggtcag gcccagcctc tctggctcag cccgggatcc     7532

tgatggcacc cacacagagg acctctttgg ggcaagatcc aggtggtccc ataggtcttg     7592

tgaaaaggct ttttcaggga aaaatatttt actagtccaa tcacccccag gacctcttca     7652

gctgctgaca atcctattta gcatatgcaa atcttttaac atagagaact gtcaccctga     7712

ggtaacaggg tcaactggcg aagcctgagc aggcaggggc ttggctgccc cattccagct     7772

ctcccatgga gcccctccac cgggcgcatg cctcccaggc cacctcagtc tcacctgccg     7832

gctctgggct ggctgctcct aacctacctc gccgagctgt cggagggctg gacatttgtg     7892

gcagtgctga agggggcatt gccggcgagt aaagtattat gtttcttctt gtcaccccag     7952

ttcccttggt ggcaacccca gacccaaccc atgcccctga cagatctagt tctcttctcc     8012

tgtgttccct ttgagtccag tgtgggacac ggtttaactg tcccagcgac atttctccaa     8072

gtggaaatcc tatttttgta gatctccatg ctttgctctc aaggcttgga gaggtatgtg     8132

cccctcctgg gtgctcaccg cctgctacac aggcaggaat gcggttggga ggcaggtcgg     8192

gctgccagcc cagctggccg gaaggagact gtggtttttg tgtgtgtgga cagcccggga     8252

gctttgagac aggtgcctgg ggctggctgc agacggtgtg gttgggggtg ggaggtgagc     8312

tagacccaac ccttagcttt tagcctggct gtcacctttt taatttccag aactgcacaa     8372

tgaccagcag gagggaagga cagacatcaa gtgccagatg ttgtctgaac taatcgagca     8432

cttctcacca aacttcatgt ataaataaaa tacatatttt taaaacaaac caataaatgg     8492

cttacatga                                                             8501


<210>  9
<211>  2015
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Glu Ser Gln Pro  Val Ser Gly 
    1070                 1075                 1080             


Gly Pro  Glu Ala Pro Pro Asp  Ser Arg Thr Trp Ser  Gln Val Ser 
    1085                 1090                 1095             


Ala Thr  Ala Ser Ser Glu Ala  Glu Ala Ser Ala Ser  Gln Ala Asp 
    1100                 1105                 1110             


Trp Arg  Gln Gln Trp Lys Ala  Glu Pro Gln Ala Pro  Gly Cys Gly 
    1115                 1120                 1125             


Glu Thr  Pro Glu Asp Ser Cys  Ser Glu Gly Ser Thr  Ala Asp Met 
    1130                 1135                 1140             


Thr Asn  Thr Ala Glu Leu Leu  Glu Gln Ile Pro Asp  Leu Gly Gln 
    1145                 1150                 1155             


Asp Val  Lys Asp Pro Glu Asp  Cys Phe Thr Glu Gly  Cys Val Arg 
    1160                 1165                 1170             


Arg Cys  Pro Cys Cys Ala Val  Asp Thr Thr Gln Ala  Pro Gly Lys 
    1175                 1180                 1185             


Val Trp  Trp Arg Leu Arg Lys  Thr Cys Tyr His Ile  Val Glu His 
    1190                 1195                 1200             


Ser Trp  Phe Glu Thr Phe Ile  Ile Phe Met Ile Leu  Leu Ser Ser 
    1205                 1210                 1215             


Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Leu Glu Glu  Arg Lys Thr 
    1220                 1225                 1230             


Ile Lys  Val Leu Leu Glu Tyr  Ala Asp Lys Met Phe  Thr Tyr Val 
    1235                 1240                 1245             


Phe Val  Leu Glu Met Leu Leu  Lys Trp Val Ala Tyr  Gly Phe Lys 
    1250                 1255                 1260             


Lys Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu Asp Phe  Leu Ile Val 
    1265                 1270                 1275             


Asp Val  Ser Leu Val Ser Leu  Val Ala Asn Thr Leu  Gly Phe Ala 
    1280                 1285                 1290             


Glu Met  Gly Pro Ile Lys Ser  Leu Arg Thr Leu Arg  Ala Leu Arg 
    1295                 1300                 1305             


Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly Met Arg  Val Val Val 
    1310                 1315                 1320             


Asn Ala  Leu Val Gly Ala Ile  Pro Ser Ile Met Asn  Val Leu Leu 
    1325                 1330                 1335             


Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser Ile Met  Gly Val Asn 
    1340                 1345                 1350             


Leu Phe  Ala Gly Lys Phe Gly  Arg Cys Ile Asn Gln  Thr Glu Gly 
    1355                 1360                 1365             


Asp Leu  Pro Leu Asn Tyr Thr  Ile Val Asn Asn Lys  Ser Gln Cys 
    1370                 1375                 1380             


Glu Ser  Leu Asn Leu Thr Gly  Glu Leu Tyr Trp Thr  Lys Val Lys 
    1385                 1390                 1395             


Val Asn  Phe Asp Asn Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln 
    1400                 1405                 1410             


Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val 
    1415                 1420                 1425             


Asp Ser  Arg Gly Tyr Glu Glu  Gln Pro Gln Trp Glu  Tyr Asn Leu 
    1430                 1435                 1440             


Tyr Met  Tyr Ile Tyr Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe 
    1445                 1450                 1455             


Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn 
    1460                 1465                 1470             


Gln Gln  Lys Lys Lys Leu Gly  Gly Gln Asp Ile Phe  Met Thr Glu 
    1475                 1480                 1485             


Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys 
    1490                 1495                 1500             


Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Leu Asn Lys  Tyr Gln Gly 
    1505                 1510                 1515             


Phe Ile  Phe Asp Ile Val Thr  Lys Gln Ala Phe Asp  Val Thr Ile 
    1520                 1525                 1530             


Met Phe  Leu Ile Cys Leu Asn  Met Val Thr Met Met  Val Glu Thr 
    1535                 1540                 1545             


Asp Asp  Gln Ser Pro Glu Lys  Ile Asn Ile Leu Ala  Lys Ile Asn 
    1550                 1555                 1560             


Leu Leu  Phe Val Ala Ile Phe  Thr Gly Glu Cys Ile  Val Lys Leu 
    1565                 1570                 1575             


Ala Ala  Leu Arg His Tyr Tyr  Phe Thr Asn Ser Trp  Asn Ile Phe 
    1580                 1585                 1590             


Asp Phe  Val Val Val Ile Leu  Ser Ile Val Gly Thr  Val Leu Ser 
    1595                 1600                 1605             


Asp Ile  Ile Gln Lys Tyr Phe  Phe Ser Pro Thr Leu  Phe Arg Val 
    1610                 1615                 1620             


Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu Arg Leu  Ile Arg Gly 
    1625                 1630                 1635             


Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu 
    1640                 1645                 1650             


Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe 
    1655                 1660                 1665             


Ile Tyr  Ser Ile Phe Gly Met  Ala Asn Phe Ala Tyr  Val Lys Trp 
    1670                 1675                 1680             


Glu Ala  Gly Ile Asp Asp Met  Phe Asn Phe Gln Thr  Phe Ala Asn 
    1685                 1690                 1695             


Ser Met  Leu Cys Leu Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp 
    1700                 1705                 1710             


Gly Leu  Leu Ser Pro Ile Leu  Asn Thr Gly Pro Pro  Tyr Cys Asp 
    1715                 1720                 1725             


Pro Thr  Leu Pro Asn Ser Asn  Gly Ser Arg Gly Asp  Cys Gly Ser 
    1730                 1735                 1740             


Pro Ala  Val Gly Ile Leu Phe  Phe Thr Thr Tyr Ile  Ile Ile Ser 
    1745                 1750                 1755             


Phe Leu  Ile Val Val Asn Met  Tyr Ile Ala Ile Ile  Leu Glu Asn 
    1760                 1765                 1770             


Phe Ser  Val Ala Thr Glu Glu  Ser Thr Glu Pro Leu  Ser Glu Asp 
    1775                 1780                 1785             


Asp Phe  Asp Met Phe Tyr Glu  Ile Trp Glu Lys Phe  Asp Pro Glu 
    1790                 1795                 1800             


Ala Thr  Gln Phe Ile Glu Tyr  Ser Val Leu Ser Asp  Phe Ala Asp 
    1805                 1810                 1815             


Ala Leu  Ser Glu Pro Leu Arg  Ile Ala Lys Pro Asn  Gln Ile Ser 
    1820                 1825                 1830             


Leu Ile  Asn Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1835                 1840                 1845             


Cys Met  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1850                 1855                 1860             


Ser Gly  Glu Met Asp Ala Leu  Lys Ile Gln Met Glu  Glu Lys Phe 
    1865                 1870                 1875             


Met Ala  Ala Asn Pro Ser Lys  Ile Ser Tyr Glu Pro  Ile Thr Thr 
    1880                 1885                 1890             


Thr Leu  Arg Arg Lys His Glu  Glu Val Ser Ala Met  Val Ile Gln 
    1895                 1900                 1905             


Arg Ala  Phe Arg Arg His Leu  Leu Gln Arg Ser Leu  Lys His Ala 
    1910                 1915                 1920             


Ser Phe  Leu Phe Arg Gln Gln  Ala Gly Ser Gly Leu  Ser Glu Glu 
    1925                 1930                 1935             


Asp Ala  Pro Glu Arg Glu Gly  Leu Ile Ala Tyr Val  Met Ser Glu 
    1940                 1945                 1950             


Asn Phe  Ser Arg Pro Leu Gly  Pro Pro Ser Ser Ser  Ser Ile Ser 
    1955                 1960                 1965             


Ser Thr  Ser Phe Pro Pro Ser  Tyr Asp Ser Val Thr  Arg Ala Thr 
    1970                 1975                 1980             


Ser Asp  Asn Leu Gln Val Arg  Gly Ser Asp Tyr Ser  His Ser Glu 
    1985                 1990                 1995             


Asp Leu  Ala Asp Phe Pro Pro  Ser Pro Asp Arg Asp  Arg Glu Ser 
    2000                 2005                 2010             


Ile Val  
    2015 


<210>  10
<211>  8504
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (195)..(6245)

<400>  10
agacggcggc ggcgcccgta ggatgcaggg atcgctcccc cggggccgct gagcctgcgc       60

ccagtgcccc gagccccgcg ccgagccgag tccgcgccaa gcagcagccg cccaccccgg      120

ggcccggccg ggggaccagc agcttcccca caggcaacgt gaggagagcc tgtgcccaga      180

agcaggatga gaag atg gca aac ttc cta tta cct cgg ggc acc agc agc        230
                Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser           
                1               5                   10                    

ttc cgc agg ttc aca cgg gag tcc ctg gca gcc atc gag aag cgc atg        278
Phe Arg Arg Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met           
        15                  20                  25                        

gca gag aag caa gcc cgc ggc tca acc acc ttg cag gag agc cga gag        326
Ala Glu Lys Gln Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu           
    30                  35                  40                            

ggg ctg ccc gag gag gag gct ccc cgg ccc cag ctg gac ctg cag gcc        374
Gly Leu Pro Glu Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala           
45                  50                  55                  60            

tcc aaa aag ctg cca gat ctc tat ggc aat cca ccc caa gag ctc atc        422
Ser Lys Lys Leu Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile           
                65                  70                  75                

gga gag ccc ctg gag gac ctg gac ccc ttc tat agc acc caa aag act        470
Gly Glu Pro Leu Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr           
            80                  85                  90                    

ttc atc gta ctg aat aaa ggc aag acc atc ttc cgg ttc agt gcc acc        518
Phe Ile Val Leu Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr           
        95                  100                 105                       

aac gcc ttg tat gtc ctc agt ccc ttc cac ccc atc cgg aga gcg gct        566
Asn Ala Leu Tyr Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala           
    110                 115                 120                           

gtg aag att ctg gtt cac tcg ctc ttc aac atg ctc atc atg tgc acc        614
Val Lys Ile Leu Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr           
125                 130                 135                 140           

atc ctc acc aac tgc gtg ttc atg gcc cag cac gac cct cca ccc tgg        662
Ile Leu Thr Asn Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp           
                145                 150                 155               

acc aag tat gtc gag tac acc ttc acc gcc att tac acc ttt gag tct        710
Thr Lys Tyr Val Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser           
            160                 165                 170                   

ctg gtc aag att ctg gct cga ggc ttc tgc ctg cac gcg ttc act ttc        758
Leu Val Lys Ile Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe           
        175                 180                 185                       

ctt cgg gac cca tgg aac tgg ctg gac ttt agt gtg att atc atg gcg        806
Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala           
    190                 195                 200                           

tat gta tca gaa aat ata aaa cta ggc aat ttg tcg gct ctt cga act        854
Tyr Val Ser Glu Asn Ile Lys Leu Gly Asn Leu Ser Ala Leu Arg Thr           
205                 210                 215                 220           

ttc aga gtc ctg aga gct cta aaa act att tca gtt atc cca ggg ctg        902
Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu           
                225                 230                 235               

aag acc atc gtg ggg gcc ctg atc cag tct gtg aag aag ctg gct gat        950
Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp           
            240                 245                 250                   

gtg atg gtc ctc aca gtc ttc tgc ctc agc gtc ttt gcc ctc atc ggc        998
Val Met Val Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly           
        255                 260                 265                       

ctg cag ctc ttc atg ggc aac cta agg cac aag tgc gtg cgc aac ttc       1046
Leu Gln Leu Phe Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe           
    270                 275                 280                           

aca gcg ctc aac ggc acc aac ggc tcc gtg gag gcc gac ggc ttg gtc       1094
Thr Ala Leu Asn Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val           
285                 290                 295                 300           

tgg gaa tcc ctg gac ctt tac ctc agt gat cca gaa aat tac ctg ctc       1142
Trp Glu Ser Leu Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu           
                305                 310                 315               

aag aac ggc acc tct gat gtg tta ctg tgt ggg aac agc tct gac gct       1190
Lys Asn Gly Thr Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala           
            320                 325                 330                   

ggg aca tgt ccg gag ggc tac cgg tgc cta aag gca ggc gag aac ccc       1238
Gly Thr Cys Pro Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro           
        335                 340                 345                       

gac cac ggc tac acc agc ttc gat tcc ttt gcc tgg gcc ttt ctt gca       1286
Asp His Gly Tyr Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala           
    350                 355                 360                           

ctc ttc cgc ctg atg acg cag gac tgc tgg gag cgc ctc tat cag cag       1334
Leu Phe Arg Leu Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln           
365                 370                 375                 380           

acc ctc agg tcc gca ggg aag atc tac atg atc ttc ttc atg ctt gtc       1382
Thr Leu Arg Ser Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val           
                385                 390                 395               

atc ttc ctg ggg tcc ttc tac ctg gtg aac ctg atc ctg gcc gtg gtc       1430
Ile Phe Leu Gly Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val           
            400                 405                 410                   

gca atg gcc tat gag gag caa aac caa gcc acc atc gct gag acc gag       1478
Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu           
        415                 420                 425                       

gag aag gaa aag cgc ttc cag gag gcc atg gaa atg ctc aag aaa gaa       1526
Glu Lys Glu Lys Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu           
    430                 435                 440                           

cac gag gcc ctc acc atc agg ggt gtg gat acc gtg tcc cgt agc tcc       1574
His Glu Ala Leu Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser           
445                 450                 455                 460           

ttg gag atg tcc cct ttg gcc cca gta aac agc cat gag aga aga agc       1622
Leu Glu Met Ser Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser           
                465                 470                 475               

aag agg aga aaa cgg atg tct tca gga act gag gag tgt ggg gag gac       1670
Lys Arg Arg Lys Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp           
            480                 485                 490                   

agg ctc ccc aag tct gac tca gaa gat ggt ccc aga gca atg aat cat       1718
Arg Leu Pro Lys Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His           
        495                 500                 505                       

ctc agc ctc acc cgt ggc ctc agc agg act tct atg aag cca cgt tcc       1766
Leu Ser Leu Thr Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser           
    510                 515                 520                           

agc cgc ggg agc att ttc acc ttt cgc agg cga gac ctg ggt tct gaa       1814
Ser Arg Gly Ser Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu           
525                 530                 535                 540           

gca gat ttt gca gat gat gaa aac agc aca gcg ggg gag agc gag agc       1862
Ala Asp Phe Ala Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser           
                545                 550                 555               

cac cac aca tca ctg ctg gtg ccc tgg ccc ctg cgc cgg acc agt gcc       1910
His His Thr Ser Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala           
            560                 565                 570                   

cag gga cag ccc agt ccc gga acc tcg gct cct ggc cac gcc ctc cat       1958
Gln Gly Gln Pro Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His           
        575                 580                 585                       

ggc aaa aag aac agc act gtg gac tgc aat ggg gtg gtc tca tta ctg       2006
Gly Lys Lys Asn Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu           
    590                 595                 600                           

ggg gca ggc gac cca gag gcc aca tcc cca gga agc cac ctc ctc cgc       2054
Gly Ala Gly Asp Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg           
605                 610                 615                 620           

cct gtg atg cta gag cac ccg cca gac acg acc acg cca tcg gag gag       2102
Pro Val Met Leu Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu           
                625                 630                 635               

cca ggc ggg ccc cag atg ctg acc tcc cag gct ccg tgt gta gat ggc       2150
Pro Gly Gly Pro Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly           
            640                 645                 650                   

ttc gag gag cca gga gca cgg cag cgg gcc ctc agc gca gtc agc gtc       2198
Phe Glu Glu Pro Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val           
        655                 660                 665                       

ctc acc agc gca ctg gaa gag tta gag gag tct cgc cac aag tgt cca       2246
Leu Thr Ser Ala Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro           
    670                 675                 680                           

cca tgc tgg aac cgt ctc gcc cag cgc tac ctg atc tgg gag tgc tgc       2294
Pro Cys Trp Asn Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys           
685                 690                 695                 700           

ccg ctg tgg atg tcc atc aag cag gga gtg aag ttg gtg gtc atg gac       2342
Pro Leu Trp Met Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp           
                705                 710                 715               

ccg ttt act gac ctc acc atc act atg tgc atc gta ctc aac aca ctc       2390
Pro Phe Thr Asp Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu           
            720                 725                 730                   

ttc atg gcg ctg gag cac tac aac atg aca agt gaa ttc gag gag atg       2438
Phe Met Ala Leu Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met           
        735                 740                 745                       

ctg cag gtc gga aac ctg gtc ttc aca ggg att ttc aca gca gag atg       2486
Leu Gln Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met           
    750                 755                 760                           

acc ttc aag atc att gcc ctc gac ccc tac tac tac ttc caa cag ggc       2534
Thr Phe Lys Ile Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly           
765                 770                 775                 780           

tgg aac atc ttc gac agc atc atc gtc atc ctt agc ctc atg gag ctg       2582
Trp Asn Ile Phe Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu           
                785                 790                 795               

ggc ctg tcc cgc atg agc aac ttg tcg gtg ctg cgc tcc ttc cgc ctg       2630
Gly Leu Ser Arg Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu           
            800                 805                 810                   

ctg cgg gtc ttc aag ctg gcc aaa tca tgg ccc acc ctg aac aca ctc       2678
Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu           
        815                 820                 825                       

atc aag atc atc ggg aac tca gtg ggg gca ctg ggg aac ctg aca ctg       2726
Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu           
    830                 835                 840                           

gtg cta gcc atc atc gtg ttc atc ttt gct gtg gtg ggc atg cag ctc       2774
Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu           
845                 850                 855                 860           

ttt ggc aag aac tac tcg gag ctg agg gac agc gac tca ggc ctg ctg       2822
Phe Gly Lys Asn Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu           
                865                 870                 875               

cct cgc tgg cac atg atg gac ttc ttt cat gcc ttc ctc atc atc ttc       2870
Pro Arg Trp His Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe           
            880                 885                 890                   

cgc atc ctc tgt gga gag tgg atc gag acc atg tgg gac tgc atg gag       2918
Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu           
        895                 900                 905                       

gtg tcg ggg cag tca tta tgc ctg ctg gtc ttc ttg ctt gtt atg gtc       2966
Val Ser Gly Gln Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val           
    910                 915                 920                           

att ggc aac ctt gtg gtc ctg aat ctc ttc ctg gcc ttg ctg ctc agc       3014
Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser           
925                 930                 935                 940           

tcc ttc agt gca gac aac ctc aca gcc cct gat gag gac aga gag atg       3062
Ser Phe Ser Ala Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met           
                945                 950                 955               

aac aac ctc cag ctg gcc ctg gcc cgc atc cag agg ggc ctg cgc ttt       3110
Asn Asn Leu Gln Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe           
            960                 965                 970                   

gtc aag cgg acc acc tgg gat ttc tgc tgt ggt ctc ctg cgg cag cgg       3158
Val Lys Arg Thr Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg           
        975                 980                 985                       

cct cag aag ccc gca gcc ctt gcc gcc cag ggc cag  ctg ccc agc tgc      3206
Pro Gln Lys Pro Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys          
    990                 995                 1000                          

att  gcc acc ccc tac tcc  ccg cca ccc cca gag  acg gag aag gtg        3251
Ile  Ala Thr Pro Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val            
1005                 1010                 1015                            

cct  ccc acc cgc aag gaa  aca cgg ttt gag gaa  ggc gag caa cca        3296
Pro  Pro Thr Arg Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro            
1020                 1025                 1030                            

ggc  cag ggc acc ccc ggg  gat cca gag ccc gtg  tgt gtg ccc atc        3341
Gly  Gln Gly Thr Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile            
1035                 1040                 1045                            

gct  gtg gcc gag tca gac  aca gat gac caa gaa  gaa gat gag gag        3386
Ala  Val Ala Glu Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu            
1050                 1055                 1060                            

aac  agc ctg ggc acg gag  gag gag tcc agc aag  cag cag gaa tcc        3431
Asn  Ser Leu Gly Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser            
1065                 1070                 1075                            

cag  cct gtg tcc ggt ggc  cca gag gcc cct ccg  gat tcc agg acc        3476
Gln  Pro Val Ser Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr            
1080                 1085                 1090                            

tgg  agc cag gtg tca gcg  act gcc tcc tct gag  gcc gag gcc agt        3521
Trp  Ser Gln Val Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser            
1095                 1100                 1105                            

gca  tct cag gcc gac tgg  cgg cag cag tgg aaa  gcg gaa ccc cag        3566
Ala  Ser Gln Ala Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln            
1110                 1115                 1120                            

gcc  cca ggg tgc ggt gag  acc cca gag gac agt  tgc tcc gag ggc        3611
Ala  Pro Gly Cys Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly            
1125                 1130                 1135                            

agc  aca gca gac atg acc  aac acc gct gag ctc  ctg gag cag atc        3656
Ser  Thr Ala Asp Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile            
1140                 1145                 1150                            

cct  gac ctc ggc cag gat  gtc aag gac cca gag  gac tgc ttc act        3701
Pro  Asp Leu Gly Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr            
1155                 1160                 1165                            

gaa  ggc tgt gtc cgg cgc  tgt ccc tgc tgt gcg  gtg gac acc aca        3746
Glu  Gly Cys Val Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr            
1170                 1175                 1180                            

cag  gcc cca ggg aag gtc  tgg tgg cgg ttg cgc  aag acc tgc tac        3791
Gln  Ala Pro Gly Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr            
1185                 1190                 1195                            

cac  atc gtg gag cac agc  tgg ttc gag aca ttc  atc atc ttc atg        3836
His  Ile Val Glu His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met            
1200                 1205                 1210                            

atc  cta ctc agc agt gga  gcg ctg gcc ttc gag  gac atc tac cta        3881
Ile  Leu Leu Ser Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu            
1215                 1220                 1225                            

gag  gag cgg aag acc atc  aag gtt ctg ctt gag  tat gcc gac aag        3926
Glu  Glu Arg Lys Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys            
1230                 1235                 1240                            

atg  ttc aca tat gtc ttc  gtg ctg gag atg ctg  ctc aag tgg gtg        3971
Met  Phe Thr Tyr Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val            
1245                 1250                 1255                            

gcc  tac ggc ttc aag aag  tac ttc acc aat gcc  tgg tgc tgg ctc        4016
Ala  Tyr Gly Phe Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu            
1260                 1265                 1270                            

gac  ttc ctc atc gta gac  gtc tct ctg gtc agc  ctg gtg gcc aac        4061
Asp  Phe Leu Ile Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn            
1275                 1280                 1285                            

acc  ctg ggc ttt gcc gag  atg ggc ccc atc aag  tca ctg cgg acg        4106
Thr  Leu Gly Phe Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr            
1290                 1295                 1300                            

ctg  cgt gca ctc cgt cct  ctg aga gct ctg tca  cga ttt gag ggc        4151
Leu  Arg Ala Leu Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly            
1305                 1310                 1315                            

atg  agg gtg gtg gtc aat  gcc ctg gtg ggc gcc  atc ccg tcc atc        4196
Met  Arg Val Val Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile            
1320                 1325                 1330                            

atg  aac gtc ctc ctc gtc  tgc ctc atc ttc tgg  ctc atc ttc agc        4241
Met  Asn Val Leu Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser            
1335                 1340                 1345                            

atc  atg ggc gtg aac ctc  ttt gcg ggg aag ttt  ggg agg tgc atc        4286
Ile  Met Gly Val Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile            
1350                 1355                 1360                            

aac  cag aca gag gga gac  ttg cct ttg aac tac  acc atc gtg aac        4331
Asn  Gln Thr Glu Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn            
1365                 1370                 1375                            

aac  aag agc cag tgt gag  tcc ttg aac ttg acc  gga gaa ttg tac        4376
Asn  Lys Ser Gln Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr            
1380                 1385                 1390                            

tgg  acc aag gtg aaa gtc  aac ttt gac aac gtg  ggg gcc ggg tac        4421
Trp  Thr Lys Val Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr            
1395                 1400                 1405                            

ctg  gcc ctt ctg cag gtg  gca aca ttt aaa ggc  tgg atg gac att        4466
Leu  Ala Leu Leu Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile            
1410                 1415                 1420                            

atg  tat gca gct gtg gac  tcc agg ggg tat gaa  gag cag cct cag        4511
Met  Tyr Ala Ala Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln            
1425                 1430                 1435                            

tgg  gaa tac aac ctc tac  atg tac atc tat ttt  gtc att ttc atc        4556
Trp  Glu Tyr Asn Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile            
1440                 1445                 1450                            

atc  ttt ggg tct ttc ttc  acc ctg aac ctc ttt  att ggt gtc atc        4601
Ile  Phe Gly Ser Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile            
1455                 1460                 1465                            

att  gac aac ttc aac caa  cag aag aaa aag tta  ggg ggc cag gac        4646
Ile  Asp Asn Phe Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp            
1470                 1475                 1480                            

atc  ttc atg aca gag gag  cag aag aag tac tac  aat gcc atg aag        4691
Ile  Phe Met Thr Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys            
1485                 1490                 1495                            

aag  ctg ggc tcc aag aag  ccc cag aag ccc atc  cca cgg ccc ctg        4736
Lys  Leu Gly Ser Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu            
1500                 1505                 1510                            

aac  aag tac cag ggc ttc  ata ttc gac att gtg  acc aag cag gcc        4781
Asn  Lys Tyr Gln Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala            
1515                 1520                 1525                            

ttt  gac gtc acc atc atg  ttt ctg atc tgc ttg  aat atg gtg acc        4826
Phe  Asp Val Thr Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr            
1530                 1535                 1540                            

atg  atg gtg gag aca gat  gac caa agt cct gag  aaa atc aac atc        4871
Met  Met Val Glu Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile            
1545                 1550                 1555                            

ttg  gcc aag atc aac ctg  ctc ttt gtg gcc atc  ttc aca ggc gag        4916
Leu  Ala Lys Ile Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu            
1560                 1565                 1570                            

tgt  att gtc aag ctg gct  gcc ctg cgc cac tac  tac ttc acc aac        4961
Cys  Ile Val Lys Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn            
1575                 1580                 1585                            

agc  tgg aat atc ttc gac  ttc gtg gtt gtc atc  ctc tcc atc gtg        5006
Ser  Trp Asn Ile Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val            
1590                 1595                 1600                            

ggc  act gtg ctc tcg gac  atc atc cag aag tac  ttc ttc tcc ccg        5051
Gly  Thr Val Leu Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro            
1605                 1610                 1615                            

acg  ctc ttc cga gtc atc  cgc ctg gcc cga ata  ggc cgc atc ctc        5096
Thr  Leu Phe Arg Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu            
1620                 1625                 1630                            

aga  ctg atc cga ggg gcc  aag ggg atc cgc acg  ctg ctc ttt gcc        5141
Arg  Leu Ile Arg Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala            
1635                 1640                 1645                            

ctc  atg atg tcc ctg cct  gcc ctc ttc aac atc  ggg ctg ctg ctc        5186
Leu  Met Met Ser Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu            
1650                 1655                 1660                            

ttc  ctc gtc atg ttc atc  tac tcc atc ttt ggc  atg gcc aac ttc        5231
Phe  Leu Val Met Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe            
1665                 1670                 1675                            

gct  tat gtc aag tgg gag  gct ggc atc gac gac  atg ttc aac ttc        5276
Ala  Tyr Val Lys Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe            
1680                 1685                 1690                            

cag  acc ttc gcc aac agc  atg ctg tgc ctc ttc  cag atc acc acg        5321
Gln  Thr Phe Ala Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr            
1695                 1700                 1705                            

tcg  gcc ggc tgg gat ggc  ctc ctc agc ccc atc  ctc aac act ggg        5366
Ser  Ala Gly Trp Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly            
1710                 1715                 1720                            

ccg  ccc tac tgc gac ccc  act ctg ccc aac agc  aat ggc tct cgg        5411
Pro  Pro Tyr Cys Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg            
1725                 1730                 1735                            

ggg  gac tgc ggg agc cca  gcc gtg ggc atc ctc  ttc ttc acc acc        5456
Gly  Asp Cys Gly Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr            
1740                 1745                 1750                            

tac  atc atc atc tcc ttc  ctc atc gtg gtc aac  atg tac att gcc        5501
Tyr  Ile Ile Ile Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala            
1755                 1760                 1765                            

atc  atc ctg gag aac ttc  agc gtg gcc acg gag  gag agc acc gag        5546
Ile  Ile Leu Glu Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu            
1770                 1775                 1780                            

ccc  ctg agt gag gac gac  ttc gat atg ttc tat  gag atc tgg gag        5591
Pro  Leu Ser Glu Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu            
1785                 1790                 1795                            

aaa  ttt gac cca gag gcc  act cag ttt att gag  tat tcg gtc ctg        5636
Lys  Phe Asp Pro Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu            
1800                 1805                 1810                            

tct  gac ttt gcc gat gcc  ctg tct gag cca ctc  cgt atc gcc aag        5681
Ser  Asp Phe Ala Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys            
1815                 1820                 1825                            

ccc  aac cag ata agc ctc  atc aac atg gac ctg  ccc atg gtg agt        5726
Pro  Asn Gln Ile Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser            
1830                 1835                 1840                            

ggg  gac cgc atc cat tgc  atg gac att ctc ttt  gcc ttc acc aaa        5771
Gly  Asp Arg Ile His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys            
1845                 1850                 1855                            

agg  gtc ctg ggg gag tct  ggg gag atg gac gcc  ctg aag atc cag        5816
Arg  Val Leu Gly Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln            
1860                 1865                 1870                            

atg  gag gag aag ttc atg  gca gcc aac cca tcc  aag atc tcc tac        5861
Met  Glu Glu Lys Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr            
1875                 1880                 1885                            

gag  ccc atc acc acc aca  ctc cgg cgc aag cac  gaa gag gtg tcg        5906
Glu  Pro Ile Thr Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser            
1890                 1895                 1900                            

gcc  atg gtt atc cag aga  gcc ttc cgc agg cac  ctg ctg caa cgc        5951
Ala  Met Val Ile Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg            
1905                 1910                 1915                            

tct  ttg aag cat gcc tcc  ttc ctc ttc cgt cag  cag gcg ggc agc        5996
Ser  Leu Lys His Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser            
1920                 1925                 1930                            

ggc  ctc tcc gaa gag gat  gcc cct gag cga gag  ggc ctc atc gcc        6041
Gly  Leu Ser Glu Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala            
1935                 1940                 1945                            

tac  gtg atg agt gag aac  ttc tcc cga ccc ctt  ggc cca ccc tcc        6086
Tyr  Val Met Ser Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser            
1950                 1955                 1960                            

agc  tcc tcc atc tcc tcc  act tcc ttc cca ccc  tcc tat gac agt        6131
Ser  Ser Ser Ile Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser            
1965                 1970                 1975                            

gtc  act aga gcc acc agc  gat aac ctc cag gtg  cgg ggg tct gac        6176
Val  Thr Arg Ala Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp            
1980                 1985                 1990                            

tac  agc cac agt gaa gat  ctc gcc gac ttc ccc  cct tct ccg gac        6221
Tyr  Ser His Ser Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp            
1995                 2000                 2005                            

agg  gac cgt gag tcc atc  gtg tga gcctcggcct ggctggccag               6265
Arg  Asp Arg Glu Ser Ile  Val                                             
2010                 2015                                                 

gacacactga aaagcagcct ttttcaccat ggcaaaccta aatgcagtca gtcacaaacc     6325

agcctggggc cttcctggct ttgggagtaa gaaatgggcc tcagccccgc ggatcaacca     6385

ggcagagttc tgtggcgccg cgtggacagc cggagcagtt ggcctgtgct tggaggcctc     6445

agatagacct gtgacctggt ctggtcaggc aatgccctgc ggctctggaa agcaacttca     6505

tcccagctgc tgaggcgaaa tataaaactg agactgtata tgttgtgaat gggctttcat     6565

aaatttatta tatttgatat ttttttactt gagcaaagaa ctaaggattt ttccatggac     6625

atgggcagca attcacgctg tctcttctta accctgaaca agagtgtcta tggagcagcc     6685

ggaagtctgt tctcaaagca gaagtggaat ccagtgtggc tcccacaggt cttcactgcc     6745

caggggtcga atggggtccc cctcccactt gacctgagat gctgggaggg ctgaaccccc     6805

actcacacaa gcacacacac acagtcctca cacacggagg ccagacacag gccgtgggac     6865

ccaggctccc agcctaaggg agacaggcct ttccctgccg gccccccaag gatggggttc     6925

ttgtccacgg ggctcactct ggccccctat tgtctccaag gtcccatttt ccccctgtgt     6985

tttcacgcag gtcatattgt cagtcctaca aaaataaaag gcttccagag gagagtggcc     7045

tgggtcccag ggctggccct aggcactgat agttgccttt tcttcccctc ctgtaagagt     7105

attaacaaaa ccaaaggaca caagggtgca agccccattc acggcctggc atgcagcttg     7165

tccttgctcc tggaacctgg caggccctgc ccagccagcc atcggaagag agggctgagc     7225

catgggggtt tggggctaag aagttcacca gccctgagcc atggcggccc ctcagcctgc     7285

ctgaagagag gaaactggcg atctcccagg gctctctgga ccatacgcgg aggagttttc     7345

tgtgtggtct ccagctcctc tccagacaca gagacatggg agtggggagc ggagcttggc     7405

cctgcgccct gtgcagggaa agggatggtc aggcccagtt ctcgtgccct tagaggggaa     7465

tgaaccatgg cacctttgag agagggggca ctgtggtcag gcccagcctc tctggctcag     7525

cccgggatcc tgatggcacc cacacagagg acctctttgg ggcaagatcc aggtggtccc     7585

ataggtcttg tgaaaaggct ttttcaggga aaaatatttt actagtccaa tcacccccag     7645

gacctcttca gctgctgaca atcctattta gcatatgcaa atcttttaac atagagaact     7705

gtcaccctga ggtaacaggg tcaactggcg aagcctgagc aggcaggggc ttggctgccc     7765

cattccagct ctcccatgga gcccctccac cgggcgcatg cctcccaggc cacctcagtc     7825

tcacctgccg gctctgggct ggctgctcct aacctacctc gccgagctgt cggagggctg     7885

gacatttgtg gcagtgctga agggggcatt gccggcgagt aaagtattat gtttcttctt     7945

gtcaccccag ttcccttggt ggcaacccca gacccaaccc atgcccctga cagatctagt     8005

tctcttctcc tgtgttccct ttgagtccag tgtgggacac ggtttaactg tcccagcgac     8065

atttctccaa gtggaaatcc tatttttgta gatctccatg ctttgctctc aaggcttgga     8125

gaggtatgtg cccctcctgg gtgctcaccg cctgctacac aggcaggaat gcggttggga     8185

ggcaggtcgg gctgccagcc cagctggccg gaaggagact gtggtttttg tgtgtgtgga     8245

cagcccggga gctttgagac aggtgcctgg ggctggctgc agacggtgtg gttgggggtg     8305

ggaggtgagc tagacccaac ccttagcttt tagcctggct gtcacctttt taatttccag     8365

aactgcacaa tgaccagcag gagggaagga cagacatcaa gtgccagatg ttgtctgaac     8425

taatcgagca cttctcacca aacttcatgt ataaataaaa tacatatttt taaaacaaac     8485

caataaatgg cttacatga                                                  8504


<210>  11
<211>  2016
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Val Ser Glu 
        195                 200                 205             


Asn Ile Lys Leu Gly Asn Leu Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Thr Val Leu 
    1595                 1600                 1605             


Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro Thr  Leu Phe Arg 
    1610                 1615                 1620             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg 
    1625                 1630                 1635             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1640                 1645                 1650             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1655                 1660                 1665             


Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe Ala  Tyr Val Lys 
    1670                 1675                 1680             


Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala 
    1685                 1690                 1695             


Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1700                 1705                 1710             


Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys 
    1715                 1720                 1725             


Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg Gly  Asp Cys Gly 
    1730                 1735                 1740             


Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr Tyr  Ile Ile Ile 
    1745                 1750                 1755             


Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala Ile  Ile Leu Glu 
    1760                 1765                 1770             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1775                 1780                 1785             


Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu Lys  Phe Asp Pro 
    1790                 1795                 1800             


Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu Ser  Asp Phe Ala 
    1805                 1810                 1815             


Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys Pro  Asn Gln Ile 
    1820                 1825                 1830             


Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1835                 1840                 1845             


His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1850                 1855                 1860             


Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln Met  Glu Glu Lys 
    1865                 1870                 1875             


Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr Glu  Pro Ile Thr 
    1880                 1885                 1890             


Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser Ala  Met Val Ile 
    1895                 1900                 1905             


Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg Ser  Leu Lys His 
    1910                 1915                 1920             


Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser Gly  Leu Ser Glu 
    1925                 1930                 1935             


Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala Tyr  Val Met Ser 
    1940                 1945                 1950             


Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser Ser  Ser Ser Ile 
    1955                 1960                 1965             


Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser Val  Thr Arg Ala 
    1970                 1975                 1980             


Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp Tyr  Ser His Ser 
    1985                 1990                 1995             


Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp Arg  Asp Arg Glu 
    2000                 2005                 2010             


Ser Ile  Val 
    2015     


<210>  12
<211>  8450
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (195)..(6191)

<400>  12
agacggcggc ggcgcccgta ggatgcaggg atcgctcccc cggggccgct gagcctgcgc       60

ccagtgcccc gagccccgcg ccgagccgag tccgcgccaa gcagcagccg cccaccccgg      120

ggcccggccg ggggaccagc agcttcccca caggcaacgt gaggagagcc tgtgcccaga      180

agcaggatga gaag atg gca aac ttc cta tta cct cgg ggc acc agc agc        230
                Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser           
                1               5                   10                    

ttc cgc agg ttc aca cgg gag tcc ctg gca gcc atc gag aag cgc atg        278
Phe Arg Arg Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met           
        15                  20                  25                        

gca gag aag caa gcc cgc ggc tca acc acc ttg cag gag agc cga gag        326
Ala Glu Lys Gln Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu           
    30                  35                  40                            

ggg ctg ccc gag gag gag gct ccc cgg ccc cag ctg gac ctg cag gcc        374
Gly Leu Pro Glu Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala           
45                  50                  55                  60            

tcc aaa aag ctg cca gat ctc tat ggc aat cca ccc caa gag ctc atc        422
Ser Lys Lys Leu Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile           
                65                  70                  75                

gga gag ccc ctg gag gac ctg gac ccc ttc tat agc acc caa aag act        470
Gly Glu Pro Leu Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr           
            80                  85                  90                    

ttc atc gta ctg aat aaa ggc aag acc atc ttc cgg ttc agt gcc acc        518
Phe Ile Val Leu Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr           
        95                  100                 105                       

aac gcc ttg tat gtc ctc agt ccc ttc cac ccc atc cgg aga gcg gct        566
Asn Ala Leu Tyr Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala           
    110                 115                 120                           

gtg aag att ctg gtt cac tcg ctc ttc aac atg ctc atc atg tgc acc        614
Val Lys Ile Leu Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr           
125                 130                 135                 140           

atc ctc acc aac tgc gtg ttc atg gcc cag cac gac cct cca ccc tgg        662
Ile Leu Thr Asn Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp           
                145                 150                 155               

acc aag tat gtc gag tac acc ttc acc gcc att tac acc ttt gag tct        710
Thr Lys Tyr Val Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser           
            160                 165                 170                   

ctg gtc aag att ctg gct cga ggc ttc tgc ctg cac gcg ttc act ttc        758
Leu Val Lys Ile Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe           
        175                 180                 185                       

ctt cgg gac cca tgg aac tgg ctg gac ttt agt gtg att atc atg gcg        806
Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala           
    190                 195                 200                           

tat gta tca gaa aat ata aaa cta ggc aat ttg tcg gct ctt cga act        854
Tyr Val Ser Glu Asn Ile Lys Leu Gly Asn Leu Ser Ala Leu Arg Thr           
205                 210                 215                 220           

ttc aga gtc ctg aga gct cta aaa act att tca gtt atc cca ggg ctg        902
Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu           
                225                 230                 235               

aag acc atc gtg ggg gcc ctg atc cag tct gtg aag aag ctg gct gat        950
Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp           
            240                 245                 250                   

gtg atg gtc ctc aca gtc ttc tgc ctc agc gtc ttt gcc ctc atc ggc        998
Val Met Val Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly           
        255                 260                 265                       

ctg cag ctc ttc atg ggc aac cta agg cac aag tgc gtg cgc aac ttc       1046
Leu Gln Leu Phe Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe           
    270                 275                 280                           

aca gcg ctc aac ggc acc aac ggc tcc gtg gag gcc gac ggc ttg gtc       1094
Thr Ala Leu Asn Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val           
285                 290                 295                 300           

tgg gaa tcc ctg gac ctt tac ctc agt gat cca gaa aat tac ctg ctc       1142
Trp Glu Ser Leu Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu           
                305                 310                 315               

aag aac ggc acc tct gat gtg tta ctg tgt ggg aac agc tct gac gct       1190
Lys Asn Gly Thr Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala           
            320                 325                 330                   

ggg aca tgt ccg gag ggc tac cgg tgc cta aag gca ggc gag aac ccc       1238
Gly Thr Cys Pro Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro           
        335                 340                 345                       

gac cac ggc tac acc agc ttc gat tcc ttt gcc tgg gcc ttt ctt gca       1286
Asp His Gly Tyr Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala           
    350                 355                 360                           

ctc ttc cgc ctg atg acg cag gac tgc tgg gag cgc ctc tat cag cag       1334
Leu Phe Arg Leu Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln           
365                 370                 375                 380           

acc ctc agg tcc gca ggg aag atc tac atg atc ttc ttc atg ctt gtc       1382
Thr Leu Arg Ser Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val           
                385                 390                 395               

atc ttc ctg ggg tcc ttc tac ctg gtg aac ctg atc ctg gcc gtg gtc       1430
Ile Phe Leu Gly Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val           
            400                 405                 410                   

gca atg gcc tat gag gag caa aac caa gcc acc atc gct gag acc gag       1478
Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu           
        415                 420                 425                       

gag aag gaa aag cgc ttc cag gag gcc atg gaa atg ctc aag aaa gaa       1526
Glu Lys Glu Lys Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu           
    430                 435                 440                           

cac gag gcc ctc acc atc agg ggt gtg gat acc gtg tcc cgt agc tcc       1574
His Glu Ala Leu Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser           
445                 450                 455                 460           

ttg gag atg tcc cct ttg gcc cca gta aac agc cat gag aga aga agc       1622
Leu Glu Met Ser Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser           
                465                 470                 475               

aag agg aga aaa cgg atg tct tca gga act gag gag tgt ggg gag gac       1670
Lys Arg Arg Lys Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp           
            480                 485                 490                   

agg ctc ccc aag tct gac tca gaa gat ggt ccc aga gca atg aat cat       1718
Arg Leu Pro Lys Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His           
        495                 500                 505                       

ctc agc ctc acc cgt ggc ctc agc agg act tct atg aag cca cgt tcc       1766
Leu Ser Leu Thr Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser           
    510                 515                 520                           

agc cgc ggg agc att ttc acc ttt cgc agg cga gac ctg ggt tct gaa       1814
Ser Arg Gly Ser Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu           
525                 530                 535                 540           

gca gat ttt gca gat gat gaa aac agc aca gcg ggg gag agc gag agc       1862
Ala Asp Phe Ala Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser           
                545                 550                 555               

cac cac aca tca ctg ctg gtg ccc tgg ccc ctg cgc cgg acc agt gcc       1910
His His Thr Ser Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala           
            560                 565                 570                   

cag gga cag ccc agt ccc gga acc tcg gct cct ggc cac gcc ctc cat       1958
Gln Gly Gln Pro Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His           
        575                 580                 585                       

ggc aaa aag aac agc act gtg gac tgc aat ggg gtg gtc tca tta ctg       2006
Gly Lys Lys Asn Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu           
    590                 595                 600                           

ggg gca ggc gac cca gag gcc aca tcc cca gga agc cac ctc ctc cgc       2054
Gly Ala Gly Asp Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg           
605                 610                 615                 620           

cct gtg atg cta gag cac ccg cca gac acg acc acg cca tcg gag gag       2102
Pro Val Met Leu Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu           
                625                 630                 635               

cca ggc ggg ccc cag atg ctg acc tcc cag gct ccg tgt gta gat ggc       2150
Pro Gly Gly Pro Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly           
            640                 645                 650                   

ttc gag gag cca gga gca cgg cag cgg gcc ctc agc gca gtc agc gtc       2198
Phe Glu Glu Pro Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val           
        655                 660                 665                       

ctc acc agc gca ctg gaa gag tta gag gag tct cgc cac aag tgt cca       2246
Leu Thr Ser Ala Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro           
    670                 675                 680                           

cca tgc tgg aac cgt ctc gcc cag cgc tac ctg atc tgg gag tgc tgc       2294
Pro Cys Trp Asn Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys           
685                 690                 695                 700           

ccg ctg tgg atg tcc atc aag cag gga gtg aag ttg gtg gtc atg gac       2342
Pro Leu Trp Met Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp           
                705                 710                 715               

ccg ttt act gac ctc acc atc act atg tgc atc gta ctc aac aca ctc       2390
Pro Phe Thr Asp Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu           
            720                 725                 730                   

ttc atg gcg ctg gag cac tac aac atg aca agt gaa ttc gag gag atg       2438
Phe Met Ala Leu Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met           
        735                 740                 745                       

ctg cag gtc gga aac ctg gtc ttc aca ggg att ttc aca gca gag atg       2486
Leu Gln Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met           
    750                 755                 760                           

acc ttc aag atc att gcc ctc gac ccc tac tac tac ttc caa cag ggc       2534
Thr Phe Lys Ile Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly           
765                 770                 775                 780           

tgg aac atc ttc gac agc atc atc gtc atc ctt agc ctc atg gag ctg       2582
Trp Asn Ile Phe Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu           
                785                 790                 795               

ggc ctg tcc cgc atg agc aac ttg tcg gtg ctg cgc tcc ttc cgc ctg       2630
Gly Leu Ser Arg Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu           
            800                 805                 810                   

ctg cgg gtc ttc aag ctg gcc aaa tca tgg ccc acc ctg aac aca ctc       2678
Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu           
        815                 820                 825                       

atc aag atc atc ggg aac tca gtg ggg gca ctg ggg aac ctg aca ctg       2726
Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu           
    830                 835                 840                           

gtg cta gcc atc atc gtg ttc atc ttt gct gtg gtg ggc atg cag ctc       2774
Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu           
845                 850                 855                 860           

ttt ggc aag aac tac tcg gag ctg agg gac agc gac tca ggc ctg ctg       2822
Phe Gly Lys Asn Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu           
                865                 870                 875               

cct cgc tgg cac atg atg gac ttc ttt cat gcc ttc ctc atc atc ttc       2870
Pro Arg Trp His Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe           
            880                 885                 890                   

cgc atc ctc tgt gga gag tgg atc gag acc atg tgg gac tgc atg gag       2918
Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu           
        895                 900                 905                       

gtg tcg ggg cag tca tta tgc ctg ctg gtc ttc ttg ctt gtt atg gtc       2966
Val Ser Gly Gln Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val           
    910                 915                 920                           

att ggc aac ctt gtg gtc ctg aat ctc ttc ctg gcc ttg ctg ctc agc       3014
Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser           
925                 930                 935                 940           

tcc ttc agt gca gac aac ctc aca gcc cct gat gag gac aga gag atg       3062
Ser Phe Ser Ala Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met           
                945                 950                 955               

aac aac ctc cag ctg gcc ctg gcc cgc atc cag agg ggc ctg cgc ttt       3110
Asn Asn Leu Gln Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe           
            960                 965                 970                   

gtc aag cgg acc acc tgg gat ttc tgc tgt ggt ctc ctg cgg cag cgg       3158
Val Lys Arg Thr Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg           
        975                 980                 985                       

cct cag aag ccc gca gcc ctt gcc gcc cag ggc cag  ctg ccc agc tgc      3206
Pro Gln Lys Pro Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys          
    990                 995                 1000                          

att  gcc acc ccc tac tcc  ccg cca ccc cca gag  acg gag aag gtg        3251
Ile  Ala Thr Pro Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val            
1005                 1010                 1015                            

cct  ccc acc cgc aag gaa  aca cgg ttt gag gaa  ggc gag caa cca        3296
Pro  Pro Thr Arg Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro            
1020                 1025                 1030                            

ggc  cag ggc acc ccc ggg  gat cca gag ccc gtg  tgt gtg ccc atc        3341
Gly  Gln Gly Thr Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile            
1035                 1040                 1045                            

gct  gtg gcc gag tca gac  aca gat gac caa gaa  gaa gat gag gag        3386
Ala  Val Ala Glu Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu            
1050                 1055                 1060                            

aac  agc ctg ggc acg gag  gag gag tcc agc aag  cag cag gaa tcc        3431
Asn  Ser Leu Gly Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser            
1065                 1070                 1075                            

cag  cct gtg tcc ggt ggc  cca gag gcc cct ccg  gat tcc agg acc        3476
Gln  Pro Val Ser Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr            
1080                 1085                 1090                            

tgg  agc cag gtg tca gcg  act gcc tcc tct gag  gcc gag gcc agt        3521
Trp  Ser Gln Val Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser            
1095                 1100                 1105                            

gca  tct cag gcc gac tgg  cgg cag cag tgg aaa  gcg gaa ccc cag        3566
Ala  Ser Gln Ala Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln            
1110                 1115                 1120                            

gcc  cca ggg tgc ggt gag  acc cca gag gac agt  tgc tcc gag ggc        3611
Ala  Pro Gly Cys Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly            
1125                 1130                 1135                            

agc  aca gca gac atg acc  aac acc gct gag ctc  ctg gag cag atc        3656
Ser  Thr Ala Asp Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile            
1140                 1145                 1150                            

cct  gac ctc ggc cag gat  gtc aag gac cca gag  gac tgc ttc act        3701
Pro  Asp Leu Gly Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr            
1155                 1160                 1165                            

gaa  ggc tgt gtc cgg cgc  tgt ccc tgc tgt gcg  gtg gac acc aca        3746
Glu  Gly Cys Val Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr            
1170                 1175                 1180                            

cag  gcc cca ggg aag gtc  tgg tgg cgg ttg cgc  aag acc tgc tac        3791
Gln  Ala Pro Gly Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr            
1185                 1190                 1195                            

cac  atc gtg gag cac agc  tgg ttc gag aca ttc  atc atc ttc atg        3836
His  Ile Val Glu His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met            
1200                 1205                 1210                            

atc  cta ctc agc agt gga  gcg ctg gcc ttc gag  gac atc tac cta        3881
Ile  Leu Leu Ser Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu            
1215                 1220                 1225                            

gag  gag cgg aag acc atc  aag gtt ctg ctt gag  tat gcc gac aag        3926
Glu  Glu Arg Lys Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys            
1230                 1235                 1240                            

atg  ttc aca tat gtc ttc  gtg ctg gag atg ctg  ctc aag tgg gtg        3971
Met  Phe Thr Tyr Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val            
1245                 1250                 1255                            

gcc  tac ggc ttc aag aag  tac ttc acc aat gcc  tgg tgc tgg ctc        4016
Ala  Tyr Gly Phe Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu            
1260                 1265                 1270                            

gac  ttc ctc atc gta gac  gtc tct ctg gtc agc  ctg gtg gcc aac        4061
Asp  Phe Leu Ile Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn            
1275                 1280                 1285                            

acc  ctg ggc ttt gcc gag  atg ggc ccc atc aag  tca ctg cgg acg        4106
Thr  Leu Gly Phe Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr            
1290                 1295                 1300                            

ctg  cgt gca ctc cgt cct  ctg aga gct ctg tca  cga ttt gag ggc        4151
Leu  Arg Ala Leu Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly            
1305                 1310                 1315                            

atg  agg gtg gtg gtc aat  gcc ctg gtg ggc gcc  atc ccg tcc atc        4196
Met  Arg Val Val Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile            
1320                 1325                 1330                            

atg  aac gtc ctc ctc gtc  tgc ctc atc ttc tgg  ctc atc ttc agc        4241
Met  Asn Val Leu Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser            
1335                 1340                 1345                            

atc  atg ggc gtg aac ctc  ttt gcg ggg aag ttt  ggg agg tgc atc        4286
Ile  Met Gly Val Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile            
1350                 1355                 1360                            

aac  cag aca gag gga gac  ttg cct ttg aac tac  acc atc gtg aac        4331
Asn  Gln Thr Glu Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn            
1365                 1370                 1375                            

aac  aag agc cag tgt gag  tcc ttg aac ttg acc  gga gaa ttg tac        4376
Asn  Lys Ser Gln Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr            
1380                 1385                 1390                            

tgg  acc aag gtg aaa gtc  aac ttt gac aac gtg  ggg gcc ggg tac        4421
Trp  Thr Lys Val Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr            
1395                 1400                 1405                            

ctg  gcc ctt ctg cag gtg  tat gaa gag cag cct  cag tgg gaa tac        4466
Leu  Ala Leu Leu Gln Val  Tyr Glu Glu Gln Pro  Gln Trp Glu Tyr            
1410                 1415                 1420                            

aac  ctc tac atg tac atc  tat ttt gtc att ttc  atc atc ttt ggg        4511
Asn  Leu Tyr Met Tyr Ile  Tyr Phe Val Ile Phe  Ile Ile Phe Gly            
1425                 1430                 1435                            

tct  ttc ttc acc ctg aac  ctc ttt att ggt gtc  atc att gac aac        4556
Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp Asn            
1440                 1445                 1450                            

ttc  aac caa cag aag aaa  aag tta ggg ggc cag  gac atc ttc atg        4601
Phe  Asn Gln Gln Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe Met            
1455                 1460                 1465                            

aca  gag gag cag aag aag  tac tac aat gcc atg  aag aag ctg ggc        4646
Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu Gly            
1470                 1475                 1480                            

tcc  aag aag ccc cag aag  ccc atc cca cgg ccc  ctg aac aag tac        4691
Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Leu Asn Lys Tyr            
1485                 1490                 1495                            

cag  ggc ttc ata ttc gac  att gtg acc aag cag  gcc ttt gac gtc        4736
Gln  Gly Phe Ile Phe Asp  Ile Val Thr Lys Gln  Ala Phe Asp Val            
1500                 1505                 1510                            

acc  atc atg ttt ctg atc  tgc ttg aat atg gtg  acc atg atg gtg        4781
Thr  Ile Met Phe Leu Ile  Cys Leu Asn Met Val  Thr Met Met Val            
1515                 1520                 1525                            

gag  aca gat gac caa agt  cct gag aaa atc aac  atc ttg gcc aag        4826
Glu  Thr Asp Asp Gln Ser  Pro Glu Lys Ile Asn  Ile Leu Ala Lys            
1530                 1535                 1540                            

atc  aac ctg ctc ttt gtg  gcc atc ttc aca ggc  gag tgt att gtc        4871
Ile  Asn Leu Leu Phe Val  Ala Ile Phe Thr Gly  Glu Cys Ile Val            
1545                 1550                 1555                            

aag  ctg gct gcc ctg cgc  cac tac tac ttc acc  aac agc tgg aat        4916
Lys  Leu Ala Ala Leu Arg  His Tyr Tyr Phe Thr  Asn Ser Trp Asn            
1560                 1565                 1570                            

atc  ttc gac ttc gtg gtt  gtc atc ctc tcc atc  gtg ggc act gtg        4961
Ile  Phe Asp Phe Val Val  Val Ile Leu Ser Ile  Val Gly Thr Val            
1575                 1580                 1585                            

ctc  tcg gac atc atc cag  aag tac ttc ttc tcc  ccg acg ctc ttc        5006
Leu  Ser Asp Ile Ile Gln  Lys Tyr Phe Phe Ser  Pro Thr Leu Phe            
1590                 1595                 1600                            

cga  gtc atc cgc ctg gcc  cga ata ggc cgc atc  ctc aga ctg atc        5051
Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu Ile            
1605                 1610                 1615                            

cga  ggg gcc aag ggg atc  cgc acg ctg ctc ttt  gcc ctc atg atg        5096
Arg  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met Met            
1620                 1625                 1630                            

tcc  ctg cct gcc ctc ttc  aac atc ggg ctg ctg  ctc ttc ctc gtc        5141
Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu Val            
1635                 1640                 1645                            

atg  ttc atc tac tcc atc  ttt ggc atg gcc aac  ttc gct tat gtc        5186
Met  Phe Ile Tyr Ser Ile  Phe Gly Met Ala Asn  Phe Ala Tyr Val            
1650                 1655                 1660                            

aag  tgg gag gct ggc atc  gac gac atg ttc aac  ttc cag acc ttc        5231
Lys  Trp Glu Ala Gly Ile  Asp Asp Met Phe Asn  Phe Gln Thr Phe            
1665                 1670                 1675                            

gcc  aac agc atg ctg tgc  ctc ttc cag atc acc  acg tcg gcc ggc        5276
Ala  Asn Ser Met Leu Cys  Leu Phe Gln Ile Thr  Thr Ser Ala Gly            
1680                 1685                 1690                            

tgg  gat ggc ctc ctc agc  ccc atc ctc aac act  ggg ccg ccc tac        5321
Trp  Asp Gly Leu Leu Ser  Pro Ile Leu Asn Thr  Gly Pro Pro Tyr            
1695                 1700                 1705                            

tgc  gac ccc act ctg ccc  aac agc aat ggc tct  cgg ggg gac tgc        5366
Cys  Asp Pro Thr Leu Pro  Asn Ser Asn Gly Ser  Arg Gly Asp Cys            
1710                 1715                 1720                            

ggg  agc cca gcc gtg ggc  atc ctc ttc ttc acc  acc tac atc atc        5411
Gly  Ser Pro Ala Val Gly  Ile Leu Phe Phe Thr  Thr Tyr Ile Ile            
1725                 1730                 1735                            

atc  tcc ttc ctc atc gtg  gtc aac atg tac att  gcc atc atc ctg        5456
Ile  Ser Phe Leu Ile Val  Val Asn Met Tyr Ile  Ala Ile Ile Leu            
1740                 1745                 1750                            

gag  aac ttc agc gtg gcc  acg gag gag agc acc  gag ccc ctg agt        5501
Glu  Asn Phe Ser Val Ala  Thr Glu Glu Ser Thr  Glu Pro Leu Ser            
1755                 1760                 1765                            

gag  gac gac ttc gat atg  ttc tat gag atc tgg  gag aaa ttt gac        5546
Glu  Asp Asp Phe Asp Met  Phe Tyr Glu Ile Trp  Glu Lys Phe Asp            
1770                 1775                 1780                            

cca  gag gcc act cag ttt  att gag tat tcg gtc  ctg tct gac ttt        5591
Pro  Glu Ala Thr Gln Phe  Ile Glu Tyr Ser Val  Leu Ser Asp Phe            
1785                 1790                 1795                            

gcc  gat gcc ctg tct gag  cca ctc cgt atc gcc  aag ccc aac cag        5636
Ala  Asp Ala Leu Ser Glu  Pro Leu Arg Ile Ala  Lys Pro Asn Gln            
1800                 1805                 1810                            

ata  agc ctc atc aac atg  gac ctg ccc atg gtg  agt ggg gac cgc        5681
Ile  Ser Leu Ile Asn Met  Asp Leu Pro Met Val  Ser Gly Asp Arg            
1815                 1820                 1825                            

atc  cat tgc atg gac att  ctc ttt gcc ttc acc  aaa agg gtc ctg        5726
Ile  His Cys Met Asp Ile  Leu Phe Ala Phe Thr  Lys Arg Val Leu            
1830                 1835                 1840                            

ggg  gag tct ggg gag atg  gac gcc ctg aag atc  cag atg gag gag        5771
Gly  Glu Ser Gly Glu Met  Asp Ala Leu Lys Ile  Gln Met Glu Glu            
1845                 1850                 1855                            

aag  ttc atg gca gcc aac  cca tcc aag atc tcc  tac gag ccc atc        5816
Lys  Phe Met Ala Ala Asn  Pro Ser Lys Ile Ser  Tyr Glu Pro Ile            
1860                 1865                 1870                            

acc  acc aca ctc cgg cgc  aag cac gaa gag gtg  tcg gcc atg gtt        5861
Thr  Thr Thr Leu Arg Arg  Lys His Glu Glu Val  Ser Ala Met Val            
1875                 1880                 1885                            

atc  cag aga gcc ttc cgc  agg cac ctg ctg caa  cgc tct ttg aag        5906
Ile  Gln Arg Ala Phe Arg  Arg His Leu Leu Gln  Arg Ser Leu Lys            
1890                 1895                 1900                            

cat  gcc tcc ttc ctc ttc  cgt cag cag gcg ggc  agc ggc ctc tcc        5951
His  Ala Ser Phe Leu Phe  Arg Gln Gln Ala Gly  Ser Gly Leu Ser            
1905                 1910                 1915                            

gaa  gag gat gcc cct gag  cga gag ggc ctc atc  gcc tac gtg atg        5996
Glu  Glu Asp Ala Pro Glu  Arg Glu Gly Leu Ile  Ala Tyr Val Met            
1920                 1925                 1930                            

agt  gag aac ttc tcc cga  ccc ctt ggc cca ccc  tcc agc tcc tcc        6041
Ser  Glu Asn Phe Ser Arg  Pro Leu Gly Pro Pro  Ser Ser Ser Ser            
1935                 1940                 1945                            

atc  tcc tcc act tcc ttc  cca ccc tcc tat gac  agt gtc act aga        6086
Ile  Ser Ser Thr Ser Phe  Pro Pro Ser Tyr Asp  Ser Val Thr Arg            
1950                 1955                 1960                            

gcc  acc agc gat aac ctc  cag gtg cgg ggg tct  gac tac agc cac        6131
Ala  Thr Ser Asp Asn Leu  Gln Val Arg Gly Ser  Asp Tyr Ser His            
1965                 1970                 1975                            

agt  gaa gat ctc gcc gac  ttc ccc cct tct ccg  gac agg gac cgt        6176
Ser  Glu Asp Leu Ala Asp  Phe Pro Pro Ser Pro  Asp Arg Asp Arg            
1980                 1985                 1990                            

gag  tcc atc gtg tga gcctcggcct ggctggccag gacacactga aaagcagcct      6231
Glu  Ser Ile Val                                                          
1995                                                                      

ttttcaccat ggcaaaccta aatgcagtca gtcacaaacc agcctggggc cttcctggct     6291

ttgggagtaa gaaatgggcc tcagccccgc ggatcaacca ggcagagttc tgtggcgccg     6351

cgtggacagc cggagcagtt ggcctgtgct tggaggcctc agatagacct gtgacctggt     6411

ctggtcaggc aatgccctgc ggctctggaa agcaacttca tcccagctgc tgaggcgaaa     6471

tataaaactg agactgtata tgttgtgaat gggctttcat aaatttatta tatttgatat     6531

ttttttactt gagcaaagaa ctaaggattt ttccatggac atgggcagca attcacgctg     6591

tctcttctta accctgaaca agagtgtcta tggagcagcc ggaagtctgt tctcaaagca     6651

gaagtggaat ccagtgtggc tcccacaggt cttcactgcc caggggtcga atggggtccc     6711

cctcccactt gacctgagat gctgggaggg ctgaaccccc actcacacaa gcacacacac     6771

acagtcctca cacacggagg ccagacacag gccgtgggac ccaggctccc agcctaaggg     6831

agacaggcct ttccctgccg gccccccaag gatggggttc ttgtccacgg ggctcactct     6891

ggccccctat tgtctccaag gtcccatttt ccccctgtgt tttcacgcag gtcatattgt     6951

cagtcctaca aaaataaaag gcttccagag gagagtggcc tgggtcccag ggctggccct     7011

aggcactgat agttgccttt tcttcccctc ctgtaagagt attaacaaaa ccaaaggaca     7071

caagggtgca agccccattc acggcctggc atgcagcttg tccttgctcc tggaacctgg     7131

caggccctgc ccagccagcc atcggaagag agggctgagc catgggggtt tggggctaag     7191

aagttcacca gccctgagcc atggcggccc ctcagcctgc ctgaagagag gaaactggcg     7251

atctcccagg gctctctgga ccatacgcgg aggagttttc tgtgtggtct ccagctcctc     7311

tccagacaca gagacatggg agtggggagc ggagcttggc cctgcgccct gtgcagggaa     7371

agggatggtc aggcccagtt ctcgtgccct tagaggggaa tgaaccatgg cacctttgag     7431

agagggggca ctgtggtcag gcccagcctc tctggctcag cccgggatcc tgatggcacc     7491

cacacagagg acctctttgg ggcaagatcc aggtggtccc ataggtcttg tgaaaaggct     7551

ttttcaggga aaaatatttt actagtccaa tcacccccag gacctcttca gctgctgaca     7611

atcctattta gcatatgcaa atcttttaac atagagaact gtcaccctga ggtaacaggg     7671

tcaactggcg aagcctgagc aggcaggggc ttggctgccc cattccagct ctcccatgga     7731

gcccctccac cgggcgcatg cctcccaggc cacctcagtc tcacctgccg gctctgggct     7791

ggctgctcct aacctacctc gccgagctgt cggagggctg gacatttgtg gcagtgctga     7851

agggggcatt gccggcgagt aaagtattat gtttcttctt gtcaccccag ttcccttggt     7911

ggcaacccca gacccaaccc atgcccctga cagatctagt tctcttctcc tgtgttccct     7971

ttgagtccag tgtgggacac ggtttaactg tcccagcgac atttctccaa gtggaaatcc     8031

tatttttgta gatctccatg ctttgctctc aaggcttgga gaggtatgtg cccctcctgg     8091

gtgctcaccg cctgctacac aggcaggaat gcggttggga ggcaggtcgg gctgccagcc     8151

cagctggccg gaaggagact gtggtttttg tgtgtgtgga cagcccggga gctttgagac     8211

aggtgcctgg ggctggctgc agacggtgtg gttgggggtg ggaggtgagc tagacccaac     8271

ccttagcttt tagcctggct gtcacctttt taatttccag aactgcacaa tgaccagcag     8331

gagggaagga cagacatcaa gtgccagatg ttgtctgaac taatcgagca cttctcacca     8391

aacttcatgt ataaataaaa tacatatttt taaaacaaac caataaatgg cttacatga      8450


<210>  13
<211>  1998
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Val Ser Glu 
        195                 200                 205             


Asn Ile Lys Leu Gly Asn Leu Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Tyr Glu Glu Gln Pro  Gln Trp Glu Tyr Asn  Leu Tyr Met 
    1415                 1420                 1425             


Tyr Ile  Tyr Phe Val Ile Phe  Ile Ile Phe Gly Ser  Phe Phe Thr 
    1430                 1435                 1440             


Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp Asn Phe  Asn Gln Gln 
    1445                 1450                 1455             


Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe Met Thr  Glu Glu Gln 
    1460                 1465                 1470             


Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu Gly Ser  Lys Lys Pro 
    1475                 1480                 1485             


Gln Lys  Pro Ile Pro Arg Pro  Leu Asn Lys Tyr Gln  Gly Phe Ile 
    1490                 1495                 1500             


Phe Asp  Ile Val Thr Lys Gln  Ala Phe Asp Val Thr  Ile Met Phe 
    1505                 1510                 1515             


Leu Ile  Cys Leu Asn Met Val  Thr Met Met Val Glu  Thr Asp Asp 
    1520                 1525                 1530             


Gln Ser  Pro Glu Lys Ile Asn  Ile Leu Ala Lys Ile  Asn Leu Leu 
    1535                 1540                 1545             


Phe Val  Ala Ile Phe Thr Gly  Glu Cys Ile Val Lys  Leu Ala Ala 
    1550                 1555                 1560             


Leu Arg  His Tyr Tyr Phe Thr  Asn Ser Trp Asn Ile  Phe Asp Phe 
    1565                 1570                 1575             


Val Val  Val Ile Leu Ser Ile  Val Gly Thr Val Leu  Ser Asp Ile 
    1580                 1585                 1590             


Ile Gln  Lys Tyr Phe Phe Ser  Pro Thr Leu Phe Arg  Val Ile Arg 
    1595                 1600                 1605             


Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu Ile Arg  Gly Ala Lys 
    1610                 1615                 1620             


Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met Met Ser  Leu Pro Ala 
    1625                 1630                 1635             


Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu Val Met  Phe Ile Tyr 
    1640                 1645                 1650             


Ser Ile  Phe Gly Met Ala Asn  Phe Ala Tyr Val Lys  Trp Glu Ala 
    1655                 1660                 1665             


Gly Ile  Asp Asp Met Phe Asn  Phe Gln Thr Phe Ala  Asn Ser Met 
    1670                 1675                 1680             


Leu Cys  Leu Phe Gln Ile Thr  Thr Ser Ala Gly Trp  Asp Gly Leu 
    1685                 1690                 1695             


Leu Ser  Pro Ile Leu Asn Thr  Gly Pro Pro Tyr Cys  Asp Pro Thr 
    1700                 1705                 1710             


Leu Pro  Asn Ser Asn Gly Ser  Arg Gly Asp Cys Gly  Ser Pro Ala 
    1715                 1720                 1725             


Val Gly  Ile Leu Phe Phe Thr  Thr Tyr Ile Ile Ile  Ser Phe Leu 
    1730                 1735                 1740             


Ile Val  Val Asn Met Tyr Ile  Ala Ile Ile Leu Glu  Asn Phe Ser 
    1745                 1750                 1755             


Val Ala  Thr Glu Glu Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe 
    1760                 1765                 1770             


Asp Met  Phe Tyr Glu Ile Trp  Glu Lys Phe Asp Pro  Glu Ala Thr 
    1775                 1780                 1785             


Gln Phe  Ile Glu Tyr Ser Val  Leu Ser Asp Phe Ala  Asp Ala Leu 
    1790                 1795                 1800             


Ser Glu  Pro Leu Arg Ile Ala  Lys Pro Asn Gln Ile  Ser Leu Ile 
    1805                 1810                 1815             


Asn Met  Asp Leu Pro Met Val  Ser Gly Asp Arg Ile  His Cys Met 
    1820                 1825                 1830             


Asp Ile  Leu Phe Ala Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly 
    1835                 1840                 1845             


Glu Met  Asp Ala Leu Lys Ile  Gln Met Glu Glu Lys  Phe Met Ala 
    1850                 1855                 1860             


Ala Asn  Pro Ser Lys Ile Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu 
    1865                 1870                 1875             


Arg Arg  Lys His Glu Glu Val  Ser Ala Met Val Ile  Gln Arg Ala 
    1880                 1885                 1890             


Phe Arg  Arg His Leu Leu Gln  Arg Ser Leu Lys His  Ala Ser Phe 
    1895                 1900                 1905             


Leu Phe  Arg Gln Gln Ala Gly  Ser Gly Leu Ser Glu  Glu Asp Ala 
    1910                 1915                 1920             


Pro Glu  Arg Glu Gly Leu Ile  Ala Tyr Val Met Ser  Glu Asn Phe 
    1925                 1930                 1935             


Ser Arg  Pro Leu Gly Pro Pro  Ser Ser Ser Ser Ile  Ser Ser Thr 
    1940                 1945                 1950             


Ser Phe  Pro Pro Ser Tyr Asp  Ser Val Thr Arg Ala  Thr Ser Asp 
    1955                 1960                 1965             


Asn Leu  Gln Val Arg Gly Ser  Asp Tyr Ser His Ser  Glu Asp Leu 
    1970                 1975                 1980             


Ala Asp  Phe Pro Pro Ser Pro  Asp Arg Asp Arg Glu  Ser Ile Val 
    1985                 1990                 1995             


<210>  14
<211>  26
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  14

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


