                         SEQUENCE LISTING

<110>  UNIVERSITE PIERRE ET MARIE CURIE-PARIS VI
 
<120>  MODULATORS OF THE CX3CR1 CHEMOKINE RECEPTOR AND THERAPEUTIC USES 
       THEREOF

<130>  BET 08P1503

<160>  64    

<170>  PatentIn version 3.4

<210>  1
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be I, T, F, Q, S, W, A, G, N or V

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be L, P or R

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be D, A, Q, G, L, I, P, H, F, V or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be N, Q, G, S, L, R, F, H, V, M, Y or P

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be V, A, D or G

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be L, M or V

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be S, P, T or A

<400>  1

Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  2
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be I, T, F, Q, S, W, A, G, N or V

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be D, A, Q, G, L, I, P, H, F, V or S

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be N, Q, G, S, L, R, F, H, V, M, Y or P

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be V, A, D or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be L, M or V

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be S, P, T or A

<400>  2

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  3
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Q or V

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Q, L or S

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be S, L or F

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be V or A

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be S or P

<400>  3

Xaa Xaa Xaa Xaa Leu Xaa 
1               5       


<210>  4
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be I, T, F, S or W

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be D, A, Q, G, I, P or S

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be N, Q, G, S, L, R, H or P

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be V, D or G

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be L or V

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be S, P, T or A

<400>  4

Xaa Leu Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be P or R

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be D or L

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be S or F

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be V or A

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be L or V

<400>  5

Gln Xaa Xaa Xaa Xaa Xaa Ala 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be L or V

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be A or S

<400>  6

Ile Leu Asp Xaa Gly Xaa Xaa 
1               5           


<210>  7
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be V, A, D or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be L, M or V

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be S, P, T or A

<400>  7

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  8
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  8

Ile Leu Asp Asn Gly Val Ser 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  9

Thr Leu Ala Gln Gly Leu Pro 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  10

Ile Leu Asp Gly Gly Val Ser 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  11

Phe Leu Gln Ser Asp Val Ala 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  12

Ile Leu Asp Leu Gly Leu Ser 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  13

Ile Leu Asp Leu Gly Leu Thr 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  14

Ile Leu Asp Asn Gly Val Ala 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  15

Ile Leu Gly Arg Asp Val Ala 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  16

Gln Pro Leu Phe Ala Val Ala 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  17

Gln Arg Asp Ser Val Leu Ala 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  18

Ser Leu Asp His Gly Leu Ser 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  19

Ser Leu Ile Pro Val Val Pro 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  20

Thr Leu Pro Gln Gly Leu Ala 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  21

Trp Leu Ser Gln Gly Leu Ala 
1               5           


<210>  22
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  22

Gln Ser Leu Val Leu Pro 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  23

Gln Leu Phe Ala Leu Ser 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  24

Val Gln Ser Val Leu Ser 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  25

Gln Pro Gly Gly Val Ser 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  26

Gln Pro Gln Ala Val Ser 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  27

Gln Pro Val Ala Leu Ala 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  28

Gln Pro Val Gly Leu Ser 
1               5       


<210>  29
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  29

Ala Ala Gln Gly Met Ser 
1               5       


<210>  30
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  30

Gln Pro Gly Ala Val Ser 
1               5       


<210>  31
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  31

Gln Pro Met Gly Val Ala 
1               5       


<210>  32
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  32

Gln Pro Gln Gly Leu Ala 
1               5       


<210>  33
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  33

Gln Pro Val Ala Val Ala 
1               5       


<210>  34
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  34

Gln His Leu Gly Leu Ser 
1               5       


<210>  35
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  35

Gln Leu Gln Gly Leu Ala 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  36

Gln Pro Ser Ala Leu Ser 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  37

Gln Ser Leu Gly Val Ser 
1               5       


<210>  38
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  38

Gly Pro Gln Ala Met Ser 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  39

Asn Pro Gln Ala Leu Ser 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  40

Gln Phe Pro Gly Val Ser 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  41

Gln Leu Leu Gly Val Ser 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  42

Gln Pro His Gly Val Ala 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  43

Gln Pro Arg Ala Leu Pro 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  44

Gln Pro Ser Ala Leu Thr 
1               5       


<210>  45
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  45

Gln Pro Ser Gly Met Ser 
1               5       


<210>  46
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  46

Gln Pro Val Ala Val Ser 
1               5       


<210>  47
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  47

Gln Pro Tyr Gly Met Ser 
1               5       


<210>  48
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  48

Gln Pro Tyr Gly Val Ser 
1               5       


<210>  49
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  49

Gln Ser Pro Gly Met Ser 
1               5       


<210>  50
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  50

Gln Val Gln Gly Val Thr 
1               5       


<210>  51
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator

<400>  51

Gln Pro Gln Gly Val Ser 
1               5       


<210>  52
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  N-terminal extremity of native human CX3CL1

<400>  52

Gln His His Gly Val Thr 
1               5       


<210>  53
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  N-terminal extremity of native murine CX3CL1

<400>  53

Gln His Leu Gly Met Thr 
1               5       


<210>  54
<211>  397
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(24)

<220>
<221>  CHAIN
<222>  (25)..(397)
<223>  Fraktaline

<220>
<221>  CHAIN
<222>  (25)..(339)
<223>  Processed Fraktaline

<220>
<221>  DOMAIN
<222>  (25)..(341)
<223>  extracellular

<220>
<221>  DOMAIN
<222>  (25)..(100)
<223>  chemokine

<220>
<221>  DOMAIN
<222>  (101)..(341)
<223>  mucine-like stalk

<220>
<221>  SITE
<222>  (339)..(340)
<223>  cleavage

<220>
<221>  TRANSMEM
<222>  (342)..(362)

<220>
<221>  DOMAIN
<222>  (363)..(397)
<223>  cytoplasmic

<400>  54

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 
            20                  25                  30          


Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
        35                  40                  45              


Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
    50                  55                  60                  


Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                85                  90                  95      


Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
            100                 105                 110         


Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
        115                 120                 125             


Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser 
    130                 135                 140                 


Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 
145                 150                 155                 160 


Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 
                165                 170                 175     


Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 
            180                 185                 190         


Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
        195                 200                 205             


Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
225                 230                 235                 240 


Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                245                 250                 255     


Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 
            260                 265                 270         


Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
        275                 280                 285             


Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 
    290                 295                 300                 


Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 
305                 310                 315                 320 


Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 
                325                 330                 335     


Ala Thr Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 
            340                 345                 350         


Phe Cys Leu Gly Val Ala Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys 
        355                 360                 365             


Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 
    370                 375                 380                 


Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 
385                 390                 395         


<210>  55
<211>  374
<212>  PRT
<213>  Artificial

<220>
<223>  mutant CX3CL1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be I, T, F, Q, S, W, A, G, N or V

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be L, P or R

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be D, A, Q, G, L, I, P, H, F, V or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be N, Q, G, S, L, R, F, H, V, M, Y or P

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be V, A, D or G

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be L, M or V

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be S, P, T or A

<400>  55

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Cys Asn Ile Thr Cys Ser Lys Met 
1               5                   10                  15      


Thr Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln 
            20                  25                  30          


Ala Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His Arg 
        35                  40                  45              


Leu Phe Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln 
    50                  55                  60                  


His Leu Asp Arg Gln Ala Ala Ala Leu Thr Arg Asn Gly Gly Thr Phe 
65                  70                  75                  80  


Glu Lys Gln Ile Gly Glu Val Lys Pro Arg Thr Thr Pro Ala Ala Gly 
                85                  90                  95      


Gly Met Asp Glu Ser Val Val Leu Glu Pro Glu Ala Thr Gly Glu Ser 
            100                 105                 110         


Ser Ser Leu Glu Pro Thr Pro Ser Ser Gln Glu Ala Gln Arg Ala Leu 
        115                 120                 125             


Gly Thr Ser Pro Glu Leu Pro Thr Gly Val Thr Gly Ser Ser Gly Thr 
    130                 135                 140                 


Arg Leu Pro Pro Thr Pro Lys Ala Gln Asp Gly Gly Pro Val Gly Thr 
145                 150                 155                 160 


Glu Leu Phe Arg Val Pro Pro Val Ser Thr Ala Ala Thr Trp Gln Ser 
                165                 170                 175     


Ser Ala Pro His Gln Pro Gly Pro Ser Leu Trp Ala Glu Ala Lys Thr 
            180                 185                 190         


Ser Glu Ala Pro Ser Thr Gln Asp Pro Ser Thr Gln Ala Ser Thr Ala 
        195                 200                 205             


Ser Ser Pro Ala Pro Glu Glu Asn Ala Pro Ser Glu Gly Gln Arg Val 
    210                 215                 220                 


Trp Gly Gln Gly Gln Ser Pro Arg Pro Glu Asn Ser Leu Glu Arg Glu 
225                 230                 235                 240 


Glu Met Gly Pro Val Pro Ala His Thr Asp Ala Phe Gln Asp Trp Gly 
                245                 250                 255     


Pro Gly Ser Met Ala His Val Ser Val Val Pro Val Ser Ser Glu Gly 
            260                 265                 270         


Thr Pro Ser Arg Glu Pro Val Ala Ser Gly Ser Trp Thr Pro Lys Ala 
        275                 280                 285             


Glu Glu Pro Ile His Ala Thr Met Asp Pro Gln Arg Leu Gly Val Leu 
    290                 295                 300                 


Ile Thr Pro Val Pro Asp Ala Gln Ala Ala Thr Arg Arg Gln Ala Val 
305                 310                 315                 320 


Gly Leu Leu Ala Phe Leu Gly Leu Leu Phe Cys Leu Gly Val Ala Met 
                325                 330                 335     


Phe Thr Tyr Gln Ser Leu Gln Gly Cys Pro Arg Lys Met Ala Gly Glu 
            340                 345                 350         


Met Ala Glu Gly Leu Arg Tyr Ile Pro Arg Ser Cys Gly Ser Asn Ser 
        355                 360                 365             


Tyr Val Leu Val Pro Val 
    370                 


<210>  56
<211>  373
<212>  PRT
<213>  Artificial

<220>
<223>  mutant CX3CL1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be V, A, D or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be L, M or V

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be S, P, T or A

<400>  56

Xaa Xaa Xaa Xaa Xaa Xaa Lys Cys Asn Ile Thr Cys Ser Lys Met Thr 
1               5                   10                  15      


Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln Ala 
            20                  25                  30          


Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His Arg Leu 
        35                  40                  45              


Phe Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln His 
    50                  55                  60                  


Leu Asp Arg Gln Ala Ala Ala Leu Thr Arg Asn Gly Gly Thr Phe Glu 
65                  70                  75                  80  


Lys Gln Ile Gly Glu Val Lys Pro Arg Thr Thr Pro Ala Ala Gly Gly 
                85                  90                  95      


Met Asp Glu Ser Val Val Leu Glu Pro Glu Ala Thr Gly Glu Ser Ser 
            100                 105                 110         


Ser Leu Glu Pro Thr Pro Ser Ser Gln Glu Ala Gln Arg Ala Leu Gly 
        115                 120                 125             


Thr Ser Pro Glu Leu Pro Thr Gly Val Thr Gly Ser Ser Gly Thr Arg 
    130                 135                 140                 


Leu Pro Pro Thr Pro Lys Ala Gln Asp Gly Gly Pro Val Gly Thr Glu 
145                 150                 155                 160 


Leu Phe Arg Val Pro Pro Val Ser Thr Ala Ala Thr Trp Gln Ser Ser 
                165                 170                 175     


Ala Pro His Gln Pro Gly Pro Ser Leu Trp Ala Glu Ala Lys Thr Ser 
            180                 185                 190         


Glu Ala Pro Ser Thr Gln Asp Pro Ser Thr Gln Ala Ser Thr Ala Ser 
        195                 200                 205             


Ser Pro Ala Pro Glu Glu Asn Ala Pro Ser Glu Gly Gln Arg Val Trp 
    210                 215                 220                 


Gly Gln Gly Gln Ser Pro Arg Pro Glu Asn Ser Leu Glu Arg Glu Glu 
225                 230                 235                 240 


Met Gly Pro Val Pro Ala His Thr Asp Ala Phe Gln Asp Trp Gly Pro 
                245                 250                 255     


Gly Ser Met Ala His Val Ser Val Val Pro Val Ser Ser Glu Gly Thr 
            260                 265                 270         


Pro Ser Arg Glu Pro Val Ala Ser Gly Ser Trp Thr Pro Lys Ala Glu 
        275                 280                 285             


Glu Pro Ile His Ala Thr Met Asp Pro Gln Arg Leu Gly Val Leu Ile 
    290                 295                 300                 


Thr Pro Val Pro Asp Ala Gln Ala Ala Thr Arg Arg Gln Ala Val Gly 
305                 310                 315                 320 


Leu Leu Ala Phe Leu Gly Leu Leu Phe Cys Leu Gly Val Ala Met Phe 
                325                 330                 335     


Thr Tyr Gln Ser Leu Gln Gly Cys Pro Arg Lys Met Ala Gly Glu Met 
            340                 345                 350         


Ala Glu Gly Leu Arg Tyr Ile Pro Arg Ser Cys Gly Ser Asn Ser Tyr 
        355                 360                 365             


Val Leu Val Pro Val 
    370             


<210>  57
<211>  336
<212>  PRT
<213>  Artificial

<220>
<223>  chimeric polypeptide


<220>
<221>  SIGNAL
<222>  (1)..(24)

<220>
<221>  MISC_FEATURE
<222>  (25)..(100)
<223>  Mutant CXC3CL1

<220>
<221>  MISC_FEATURE
<222>  (101)..(336)
<223>  Fragment of an immunoglobulin

<400>  57

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Gly Ile Leu Asp Asn Gly Val Ser Cys 
            20                  25                  30          


Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
        35                  40                  45              


Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
    50                  55                  60                  


Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                85                  90                  95      


Thr Arg Asn Gly Ala Ala Ala His Pro Arg Gly Pro Thr Ile Lys Pro 
            100                 105                 110         


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
    130                 135                 140                 


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
145                 150                 155                 160 


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
                165                 170                 175     


Gln Thr Gln Thr His Arg Glu Asp Tyr Asp Ser Thr Leu Arg Val Val 
            180                 185                 190         


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Ala Phe 
        195                 200                 205             


Ala Cys Ala Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Gly Arg Thr 
    210                 215                 220                 


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
                245                 250                 255     


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
            260                 265                 270         


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
        275                 280                 285             


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
    290                 295                 300                 


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
305                 310                 315                 320 


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Pro Pro Gly Lys 
                325                 330                 335     


<210>  58
<211>  1194
<212>  DNA
<213>  Homo sapiens

<400>  58
atggctccga tatctctgtc gtggctgctc cgcttggcca ccttctgcca tctgactgtc     60

ctgctggctg gacagcacca cggtgtgacg aaatgcaaca tcacgtgcag caagatgaca    120

tcaaagatac ctgtagcttt gctcatccac tatcaacaga accaggcatc atgcggcaaa    180

cgcgcaatca tcttggagac gagacagcac aggctgttct gtgccgaccc gaaggagcaa    240

tgggtcaagg acgcgatgca gcatctggac cgccaggctg ctgccctaac tcgaaatggc    300

ggcaccttcg agaagcagat cggcgaggtg aagcccagga ccacccctgc cgccggggga    360

atggacgagt ctgtggtcct ggagcccgaa gccacaggcg aaagcagtag cccggagccg    420

actccttctt cccaggaagc acagagggcc ctggggacct ccccagagct gccgacgggc    480

gtgactggtt cctcagggac caggctcccc ccgacgccaa aggctcagga tggagggcct    540

gtgggcacgg agcttttccg agtgcctccc gtctccactg ccgccacgtg gcagagttct    600

gctccccacc aacctgggcc cagcctctgg gctgaggcaa agacctctga ggccccgtcc    660

acccaggacc cctccaccca ggcctccact gcgtcctccc cagccccaga ggagaatgct    720

ccgtctgaag gccagcgtgt gtggggtcag ggacagagcc ccaggccaga gaactctctg    780

gagcgggagg agatgggtcc cgtgccagcg cacacggatg ccttccagga ctgggggcct    840

ggcagcatgg cccacgtctc tgtggtccct gtctcctcag aagggacccc cagcagggag    900

ccagtggctt caggcagctg gacccctaag gctgaggaac ccatccatgc caccatggac    960

ccccagaggc tgggcgtcct tatcactcct gtccctgacg cccaggctgc cacccggagg   1020

caggcggtgg ggctgctggc cttccttggc ctcctcttct gcctgggggt ggccatgttc   1080

acctaccaga gcctccaggg ctgccctcga aagatggcag gagagatggc ggagggcctt   1140

cgctacatcc cccggagctg tggtagtaat tcatatgtcc tggtgcccgt ttaa         1194


<210>  59
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide

<400>  59
ccggccatgg cccagcacca cggtgtgac                                       29


<210>  60
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide

<400>  60
ttgttctgcg gccgcgccat ttcgagttag                                      30


<210>  61
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or t

<400>  61
ccggccatgg ccnnkcnann knnkgncntg ncaaaatgca acatcacgtg c              51


<210>  62
<211>  105
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide

<400>  62
aaaactgcag ccatggctcc gatatctctg tcgtggctgc tccgcttggc caccttctgc     60

catctgactg tcctgctggc tggaattcta gataatggcg tgtca                    105


<210>  63
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  64
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CX3CR1 modulator


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be L, P, Q or R

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be V, A, D or G

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be L, M or V

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be S, P, T or A

<400>  64

Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


