                         SEQUENCE LISTING

<110>  INSERM
 
<120>  SERINE PROTEASE DERIVATIVES AND USES FOR THE PREVENTION AND/OR 
       THE TREATMENT OF BLOOD COAGULATION DISORDERS

<130>  BIO08687 CHRISTOPHE / MP

<160>  36    

<170>  PatentIn version 3.3

<210>  1
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        115                 120                 125             


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    130                 135                 140                 


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                165                 170                 175     


Leu Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly 
            180                 185                 190         


Glu Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu 
        195                 200                 205             


Asp Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 
    210                 215                 220                 


Pro Glu Arg Gly Asp Asn Asn Leu Thr Arg Ile Val Gly Gly Gln Glu 
225                 230                 235                 240 


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
                245                 250                 255     


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
            260                 265                 270         


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 
        275                 280                 285             


Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu 
    290                 295                 300                 


Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp 
305                 310                 315                 320 


Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met 
                325                 330                 335     


Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 
            340                 345                 350         


Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 
        355                 360                 365             


Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 
    370                 375                 380                 


Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 
385                 390                 395                 400 


Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 
                405                 410                 415     


Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe 
            420                 425                 430         


Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys 
        435                 440                 445             


Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg 
    450                 455                 460                 


Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 
465                 470                 475                 480 


Val Ile Thr Ser Ser Pro Leu Lys 
                485             


<210>  2
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile 
1               5                   10                  15      


Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro 
            20                  25                  30          


Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg Gly Asp Asn 
        35                  40                  45              


Asn Leu Thr Arg 
    50          


<210>  3
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala Thr Trp Gly Ile 
1               5                   10                  15      


Ser Gly Thr Pro Ala Pro Leu Asp Ser Val Phe Ser Ser Ser Glu Arg 
            20                  25                  30          


Ala His Gln Val Leu Arg Ile Arg Lys Arg Ala Asn Ser Phe Leu Glu 
        35                  40                  45              


Glu Leu Arg His Ser Ser Leu Glu Arg Glu Cys Ile Glu Glu Ile Cys 
    50                  55                  60                  


Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln Asn Val Asp Asp Thr Leu 
65                  70                  75                  80  


Ala Phe Trp Ser Lys His Val Asp Gly Asp Gln Cys Leu Val Leu Pro 
                85                  90                  95      


Leu Glu His Pro Cys Ala Ser Leu Cys Cys Gly His Gly Thr Cys Ile 
            100                 105                 110         


Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys Arg Ser Gly Trp Glu Gly 
        115                 120                 125             


Arg Phe Cys Gln Arg Glu Val Ser Phe Leu Asn Cys Ser Leu Asp Asn 
    130                 135                 140                 


Gly Gly Cys Thr His Tyr Cys Leu Glu Glu Val Gly Trp Arg Arg Cys 
145                 150                 155                 160 


Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp Asp Leu Leu Gln Cys His 
                165                 170                 175     


Pro Ala Val Lys Phe Pro Cys Gly Arg Pro Trp Lys Arg Met Glu Lys 
            180                 185                 190         


Lys Arg Ser His Leu Lys Arg Asp Thr Glu Asp Gln Glu Asp Gln Val 
        195                 200                 205             


Asp Pro Arg Leu Ile Asp Gly Lys Met Thr Arg Arg Gly Asp Ser Pro 
    210                 215                 220                 


Trp Gln Val Val Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Ala 
225                 230                 235                 240 


Val Leu Ile His Pro Ser Trp Val Leu Thr Ala Ala His Cys Met Asp 
                245                 250                 255     


Glu Ser Lys Lys Leu Leu Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg 
            260                 265                 270         


Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile Lys Glu Val Phe Val His 
        275                 280                 285             


Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn Asp Ile Ala Leu Leu His 
    290                 295                 300                 


Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr Ile Val Pro Ile Cys Leu 
305                 310                 315                 320 


Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu Asn Gln Ala Gly Gln Glu 
                325                 330                 335     


Thr Leu Val Thr Gly Trp Gly Tyr His Ser Ser Arg Glu Lys Glu Ala 
            340                 345                 350         


Lys Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys Ile Pro Val Val 
        355                 360                 365             


Pro His Asn Glu Cys Ser Glu Val Met Ser Asn Met Val Ser Glu Asn 
    370                 375                 380                 


Met Leu Cys Ala Gly Ile Leu Gly Asp Arg Gln Asp Ala Cys Glu Gly 
385                 390                 395                 400 


Asp Ser Gly Gly Pro Met Val Ala Ser Phe His Gly Thr Trp Phe Leu 
                405                 410                 415     


Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Leu Leu His Asn Tyr 
            420                 425                 430         


Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp Ile His Gly His 
        435                 440                 445             


Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser Trp Ala Pro 
    450                 455                 460     


<210>  4
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly Gly Val Arg 
1               5                   10                  15      


<210>  5
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is G or V

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is V or P

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is I, A or S

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is V or F

<400>  5

Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly Xaa Xaa Arg 
1               5                   10                  15      


Xaa Xaa Gly 
            


<210>  6
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is V or G

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is V or P

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is I, A or S

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is V or F

<400>  6

Asp Phe Leu Ala Glu Gly Gly Xaa Xaa Arg Xaa Xaa Gly 
1               5                   10              


<210>  7
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  7

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ile Val Gly 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  8

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ala Val Gly 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  9

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ser Val Gly 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  10

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ile Phe Gly 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  11

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ala Phe Gly 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  12

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ser Phe Gly 
1               5                   10              


<210>  13
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is L, A or S

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is I or F

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is G or D

<400>  13

Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly Gly Val Arg 
1               5                   10                  15      


Xaa Xaa Xaa 
            


<210>  14
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURES
<222>  (11)..(11)
<223>  X is L, A or S

<220>
<221>  MISC_FEATURES
<222>  (12)..(12)
<223>  X is I or F

<220>
<221>  MISC_FEATURES
<222>  (13)..(13)
<223>  X is G or D

<400>  14

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Xaa Xaa Xaa 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  15

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Leu Ile Asp 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  16

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Leu Ile Gly 
1               5                   10              


<210>  17
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  17

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ala Ile Asp 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  18

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ala Ile Gly 
1               5                   10              


<210>  19
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  19

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ser Ile Asp 
1               5                   10              


<210>  20
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  20

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ser Ile Gly 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  21

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ala Phe Asp 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  22

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ala Phe Gly 
1               5                   10              


<210>  23
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  23

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ser Phe Asp 
1               5                   10              


<210>  24
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  24

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ser Phe Gly 
1               5                   10              


<210>  25
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  25

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Leu Phe Asp 
1               5                   10              


<210>  26
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  26

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Leu Phe Gly 
1               5                   10              


<210>  27
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  27

Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
1               5                   10          


<210>  28
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Primers

<400>  28
ctggaacgcc ggaagaggga cctgcttgac ttcaaccaga cgcag                     45


<210>  29
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Primers

<400>  29
gttgaagtcc agcaggtccc tcttccgacg ttccagtgtc tgttt                     45


<210>  30
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Primers

<400>  30
gactttctag ctgaaggagg aggcgtgcgt atcgtgggag gccaggaatg c              51


<210>  31
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Primers

<400>  31
cctcctcctt ctgctagaaa gtctctcttt ctgcgttcca gggtctgttt                50


<210>  32
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Primers

<400>  32
cctcctcctt ctgctagaaa gtccctggtc aggttgttgt cg                        42


<210>  33
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primers

<400>  33
cttgacttcg cccagacgca gcct                                            24


<210>  34
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primers

<400>  34
aggctgcgtc tgggggaagt caag                                            24


<210>  35
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Primers

<400>  35
ggcgacaatg ctctcaccag gatcgt                                          26


<210>  36
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Primers

<400>  36
gatcctggtg agagcattgt cgcccct                                         27


