                         SEQUENCE LISTING

<110>  ZACHARIAS, DAVID A
       PLANEY, SONIA L
 
<120>  CELL-BASED DETECTION OF APF FOR DIAGNOSIS OF INTERSTITIAL 
       CYSTITIS

<130>  C1304/20002

<150>  61/122,157
<151>  2008-12-12

<160>  22    

<170>  PatentIn version 3.3

<210>  1
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  1
caccggtacc atgccctcgg ccaaacaaag g                                    31


<210>  2
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  2
aattctcgag gaccttttcg tgaatcttct ccactttcac                           40


<210>  3
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  3
tattctcgag atggtgagca agggcgagga                                      30


<210>  4
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  4
ctcggaattc ttacttgtac agctcgtcca                                      30


<210>  5
<211>  2913
<212>  DNA
<213>  Homo sapiens

<400>  5
gggggagccc ctgcaagttt cccgggccgc gcgccgcgct cgctcgcctc ccagcccgcg     60

gcccgagccg ccgccgcgcc cgccatgccc tcggccaaac aaaggggctc caagggcggc    120

cacggcgccg cgagcccctc ggagaagggt gcccacccgt cgggcggcgc ggatgacgtg    180

gcgaagaagc cgccgccggc gccgcagcag ccgccgccgc cgcccgcgcc gcacccgcag    240

cagcacccgc agcagcaccc gcagaaccag gcgcacggca agggcggcca ccgcggcggc    300

ggcggcggcg gcggcaagtc ctcctcctcc tcctccgcct ccgccgccgc tgccgccgcc    360

gccgcctcgt cctcggcgtc ctgctcgcgc aggctcggca gggcgctcaa ctttctcttc    420

tacctcgccc tggtggcggc ggccgctttc tcgggctggt gcgtccacca cgtcctggag    480

gaggtccagc aggtccggcg cagccaccag gacttctccc ggcagaggga ggagctgggc    540

cagggcttgc agggcgtcga gcagaaggtg cagtctttgc aagccacatt tggaactttt    600

gagtccatct tgagaagctc ccaacataaa caagacctca cagagaaagc tgtgaagcaa    660

ggggagagtg aggtcagccg gatcagcgaa gtgctgcaga aactccagaa tgagattctc    720

aaagacctct cggatgggat ccatgtggtg aaggacgccc gggagcggga cttcacgtcc    780

ctggagaaca cggtggagga gcggctgacg gagctcacca aatccatcaa cgacaacatc    840

gccatcttca cagaagtcca gaagaggagc cagaaggaga tcaatgacat gaaggcaaag    900

gttgcctccc tggaagaatc tgaggggaac aagcaggatt tgaaagcctt aaaggaagct    960

gtgaaggaga tacagacctc agccaagtcc agagagtggg acatggaggc cctgagaagt   1020

acccttcaga ctatggagtc tgacatctac accgaggttc gcgagctggt gagcctcaag   1080

caggagcagc aggctttcaa ggaggcggcc gacacggagc ggctcgccct gcaggccctc   1140

acggagaagc ttctcaggtc tgaggagtcc gtctcccgcc tcccggagga gatccggaga   1200

ctggaggaag agctccgcca gctgaagtcc gattcccacg ggccgaagga ggacggaggc   1260

ttcagacact cggaagcctt tgaggcactc cagcaaaaga gtcagggact ggactccagg   1320

ctccagcacg tggaggatgg ggtgctctcc atgcaggtgg cttctgcgcg ccagaccgag   1380

agcctggagt ccctcctgtc caagagccag gagcacgagc agcgcctggc cgccctgcag   1440

gggcgcctgg aaggcctcgg gtcctcagag gcagaccagg atggcctggc cagcacggtg   1500

aggagcctgg gcgagaccca gctggtgctc tacggtgacg tggaggagct gaagaggagt   1560

gtgggcgagc tccccagcac cgtggaatca ctccagaagg tgcaggagca ggtgcacacg   1620

ctgctcagtc aggaccaagc ccaggccgcc cgtctgcctc ctcaggactt cctggacaga   1680

ctttcttctc tagacaacct gaaagcctca gtcagccaag tggaggcgga cttgaaaatg   1740

ctcaggactg ctgtggacag tttggttgca tactcggtca aaatagaaac caacgagaac   1800

aatctggaat cagccaaggg tttactagat gacctgagga atgatctgga taggttgttt   1860

gtgaaagtgg agaagattca cgaaaaggtc taaatgaatt gcgtgtgcag ggcgcggatt   1920

taaagtccaa tttctcatga ccaaaaaatg tgtggttttt tcccatgtgt cccctacccc   1980

ccaatttctt gtcccctctt aaagagcagt tgtcaccacc tgaacaccaa ggcattgtat   2040

tttcatgccc agttaactta tttacaatat ttaagttctc tgcttctgca tttggttggt   2100

ttcctgaagc gcagcccctg tgaataacag gtggcttttc atggatgtct ctagtcagag   2160

aaaaatgata aaggcttaaa ttgaggatta acagaagcag attaacctca gaaatcctgt   2220

ctggctggca gatttcaagt aaaaaaaaaa aaaaggtggg ttggggggac ccttttcttt   2280

ctagttgtct ttaaggaaaa ttaattttac tttttttttt gttctggccg aaatttttat   2340

gagatatctc tcacttgtct tccactttga accggttaaa gctcatagct gtcagctctg   2400

aatgaggagg ggagaagccc ctgggtcttt ctttgaaagg aatccgctgc ttgagggctg   2460

cctccctcat ggtgtgcgtg tcgttctctt cctgacgcat ctgtgatatc agaggtaact   2520

atgcaaagca tccaggcggt tctgaatgtg aagcactaca cccagcagag tcccggtgcc   2580

ctctgtcccc actgccggcc catgtcctct ctccggaggt caccaaggaa tgcacaggtt   2640

tcgactacca gaaaggggag tccttgggtt ctttcaaaaa attcgtgagg agagctgtct   2700

acagtggaat agggggtctc cctggggaat gcaggccaag tccttttatt ttaacatgat   2760

gtccatgaag aggtttgccg tctgggcagc cctgtcggca aggagcgtgc atactgcgtt   2820

tgtgtaattg tttgctgtat ctcccttccc tctgagctgt attgttcttt aatggctgtc   2880

ttgcccttcc aaaaaaaatt gaaaaaaaaa aaa                                2913


<210>  6
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Ser Ala Lys Gln Arg Gly Ser Lys Gly Gly His Gly Ala Ala 
1               5                   10                  15      


Ser Pro Ser Glu Lys Gly Ala His Pro Ser Gly Gly Ala Asp Asp Val 
            20                  25                  30          


Ala Lys Lys Pro Pro Pro Ala Pro Gln Gln Pro Pro Pro Pro Pro Ala 
        35                  40                  45              


Pro His Pro Gln Gln His Pro Gln Gln His Pro Gln Asn Gln Ala His 
    50                  55                  60                  


Gly Lys Gly Gly His Arg Gly Gly Gly Gly Gly Gly Gly Lys Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser 
                85                  90                  95      


Ser Ala Ser Cys Ser Arg Arg Leu Gly Arg Ala Leu Asn Phe Leu Phe 
            100                 105                 110         


Tyr Leu Ala Leu Val Ala Ala Ala Ala Phe Ser Gly Trp Cys Val His 
        115                 120                 125             


His Val Leu Glu Glu Val Gln Gln Val Arg Arg Ser His Gln Asp Phe 
    130                 135                 140                 


Ser Arg Gln Arg Glu Glu Leu Gly Gln Gly Leu Gln Gly Val Glu Gln 
145                 150                 155                 160 


Lys Val Gln Ser Leu Gln Ala Thr Phe Gly Thr Phe Glu Ser Ile Leu 
                165                 170                 175     


Arg Ser Ser Gln His Lys Gln Asp Leu Thr Glu Lys Ala Val Lys Gln 
            180                 185                 190         


Gly Glu Ser Glu Val Ser Arg Ile Ser Glu Val Leu Gln Lys Leu Gln 
        195                 200                 205             


Asn Glu Ile Leu Lys Asp Leu Ser Asp Gly Ile His Val Val Lys Asp 
    210                 215                 220                 


Ala Arg Glu Arg Asp Phe Thr Ser Leu Glu Asn Thr Val Glu Glu Arg 
225                 230                 235                 240 


Leu Thr Glu Leu Thr Lys Ser Ile Asn Asp Asn Ile Ala Ile Phe Thr 
                245                 250                 255     


Glu Val Gln Lys Arg Ser Gln Lys Glu Ile Asn Asp Met Lys Ala Lys 
            260                 265                 270         


Val Ala Ser Leu Glu Glu Ser Glu Gly Asn Lys Gln Asp Leu Lys Ala 
        275                 280                 285             


Leu Lys Glu Ala Val Lys Glu Ile Gln Thr Ser Ala Lys Ser Arg Glu 
    290                 295                 300                 


Trp Asp Met Glu Ala Leu Arg Ser Thr Leu Gln Thr Met Glu Ser Asp 
305                 310                 315                 320 


Ile Tyr Thr Glu Val Arg Glu Leu Val Ser Leu Lys Gln Glu Gln Gln 
                325                 330                 335     


Ala Phe Lys Glu Ala Ala Asp Thr Glu Arg Leu Ala Leu Gln Ala Leu 
            340                 345                 350         


Thr Glu Lys Leu Leu Arg Ser Glu Glu Ser Val Ser Arg Leu Pro Glu 
        355                 360                 365             


Glu Ile Arg Arg Leu Glu Glu Glu Leu Arg Gln Leu Lys Ser Asp Ser 
    370                 375                 380                 


His Gly Pro Lys Glu Asp Gly Gly Phe Arg His Ser Glu Ala Phe Glu 
385                 390                 395                 400 


Ala Leu Gln Gln Lys Ser Gln Gly Leu Asp Ser Arg Leu Gln His Val 
                405                 410                 415     


Glu Asp Gly Val Leu Ser Met Gln Val Ala Ser Ala Arg Gln Thr Glu 
            420                 425                 430         


Ser Leu Glu Ser Leu Leu Ser Lys Ser Gln Glu His Glu Gln Arg Leu 
        435                 440                 445             


Ala Ala Leu Gln Gly Arg Leu Glu Gly Leu Gly Ser Ser Glu Ala Asp 
    450                 455                 460                 


Gln Asp Gly Leu Ala Ser Thr Val Arg Ser Leu Gly Glu Thr Gln Leu 
465                 470                 475                 480 


Val Leu Tyr Gly Asp Val Glu Glu Leu Lys Arg Ser Val Gly Glu Leu 
                485                 490                 495     


Pro Ser Thr Val Glu Ser Leu Gln Lys Val Gln Glu Gln Val His Thr 
            500                 505                 510         


Leu Leu Ser Gln Asp Gln Ala Gln Ala Ala Arg Leu Pro Pro Gln Asp 
        515                 520                 525             


Phe Leu Asp Arg Leu Ser Ser Leu Asp Asn Leu Lys Ala Ser Val Ser 
    530                 535                 540                 


Gln Val Glu Ala Asp Leu Lys Met Leu Arg Thr Ala Val Asp Ser Leu 
545                 550                 555                 560 


Val Ala Tyr Ser Val Lys Ile Glu Thr Asn Glu Asn Asn Leu Glu Ser 
                565                 570                 575     


Ala Lys Gly Leu Leu Asp Asp Leu Arg Asn Asp Leu Asp Arg Leu Phe 
            580                 585                 590         


Val Lys Val Glu Lys Ile His Glu Lys Val 
        595                 600         


<210>  7
<211>  4012
<212>  DNA
<213>  Homo sapiens

<400>  7
gtgggagccc gcgaggtggc ccgagcgagg gccccgcatc cccgcagagc ccgcccgagg     60

gcgcagcctg ccacgccagg ggaggcggcc gggcggcggg gaacggcggg ggcggagcgc    120

agcctcccga cgccgccgcc tcaccgcccc cctccgcctc ctcggcctcc gctcgcagcc    180

gccgcctccg cctccgccgg gctgaggagc cgggagtccg ccgcgccggc tcggggctgc    240

gggatgggga gttagcgcca cggcggcggc agtggccgca gcgcaccccg ccgccgccca    300

ggagcccgtc cagccagggg tgccgggccc gcccagcccg ccccggagcc aggcccgcgg    360

gcggcggcgg agctgggcag gtggatgcgg ctggaagatg gcgccctcgg gcccgggcag    420

cagcgccagg cggcggtgcc ggcgggtgct gtactggatc ccggtggtgt tcatcaccct    480

cctgctcggc tggtcctact acgcctacgc catccagctg tgcatagtgt ccatggaaaa    540

cactggcgaa caagttgtgt gcctgatggc ctatcatcta ctttttgcaa tgtttgtctg    600

gtcatactgg aaaactatct ttacattacc aatgaatcct tcaaaagaat tccatctctc    660

ttatgcagag aaagatttgt tggagagaga gccaagagga gaagcccatc aggaagttct    720

taggcgagca gccaaggatc ttcccatcta taccaggacc atgtctggag ccatccgata    780

ctgtgacaga tgccaactta taaaaccaga tcgctgccat cactgctccg tctgtgataa    840

atgtattttg aagatggatc atcattgtcc atgggtgaac aattgtgttg gattttcaaa    900

ttataagttc tttctccttt tcttggctta ttctctgctc tactgccttt ttattgcggc    960

aacagattta cagtatttta tcaaattttg gacaaatggc ctacctgata ctcaagccaa   1020

gttccatatt atgtttttat tctttgctgc agctatgttt tctgtcagct tgtcttctct   1080

gtttggctat cattgttggc tagtcagcaa aaataaatct acattagagg cattcagaag   1140

tccagtattt cgacatggaa cagataagaa tggattcagc ttgggtttca gtaaaaacat   1200

gcgacaagtt tttggtgatg agaagaagta ctggttgcta cccatttttt caagtctagg   1260

tgatggctgc tcctttccaa cttgccttgt taaccaggat cctgaacaag catctactcc   1320

tgcagggctg aattccacag ctaaaaatct cgaaaaccat cagtttcctg caaagccatt   1380

gagagagtcc cagagccacc ttcttactga ttctcagtct tggacggaga gcagcataaa   1440

cccaggaaaa tgcaaagctg gtatgagcaa tcctgcatta accatggaaa atgagactta   1500

actcttcaag caagataaat tcatacttta taaaagtatc aatgctgtag atggatggaa   1560

gaggcttccc acaggaaggt gccaccagtc agttgtgcct atgtcccttt ggctggaaat   1620

gcagaatatg aattgattag ttctctccaa gccattgctt aaaatataac atgttttgga   1680

tccaatacac acattgttac aactaacaca aattcctatt aaatattaaa agtagttctg   1740

gtttattaat caacggggaa aacatcttct ccaaaaaact tggaataaat ccaaggacca   1800

gtttttaccc aaatatatgg gtagcacagt ttatcacata gaaactccat taatcatctg   1860

attttccgaa tctgaaaatt gagactatta agatattagg atttcagaga tttcaagtca   1920

cattataatg ataagcatta ttcataaaac ttgttacctt taagaaggtg gaagtggcaa   1980

accatacttc ttttttttcc tctgatgtga atccagcctc agactgagtg aactgtaata   2040

attatgaatt cattacagag tccaggtggc ctgcagttga agatcatcaa ccatttttgc   2100

ctcacttaat tccagccttt tgttttctgc tggaaaataa gtgtggacat tgaagcttga   2160

gctctcaaag cagttggctg gaatactttt gtcagaatac ggtacatttc tattacatca   2220

gaaatatatt ttcatctctt cttgttaaat tgggaggaaa tttatgatag caattatgaa   2280

gattgtttta tgacattctt ttgtcagttt ggctttctaa aaatctcttt ttagattatt   2340

tctcctgttg aacatagtaa aactattgaa tttctcttaa gaattcctaa taggtcaata   2400

gatttaccct ccagtgatat ctatattatt tctttctcgt ctcatcaaaa tgatgacagg   2460

taaactatat ttttccttaa acacctatta cagttaaatt atgcaaatca ttaaataaaa   2520

atcatacaac ttttggaaag ttagttcaac atgaactaaa atggcatgct atttggaaat   2580

ttagtttgag ataaactaaa gtgtgttgat gccagaatgt tcagcttcag taaatataat   2640

aagctcttgt gccttgtatg cactatttaa aaaaagtttt ttttatttga gtccagtata   2700

attcatgtaa atgttaacaa ttagaataat actctgtatg cttttttgat actgattttg   2760

agaatttaaa gcagattacc ttttaaaact ggaccaacta agtaattggt atttaatcaa   2820

agagaaaatg gtaataaact tttcaaaatc tttgttaaac caaacattca acacaaaata   2880

aactagaagg ccagaggata atggaataaa agatcattgc aattacttat ccttcctaaa   2940

aatatagttt tatattaatt gtgcttatgg aagaaacaat gtcagccaag tccattttat   3000

agtttgagtg caattctttg aacaatagaa atatctgcag tctttcacag atttgtatta   3060

tgctgaagag tttcatctga caatctgctt caagaaatct cagaaaatat gataacattt   3120

taactttcat tttagagcac gttttggtca tttttaaaaa tacctaaagt gccagaccgg   3180

aacctatagc tactgctaga agtcttaaaa aaaccaacag cagcacagga tgtattaaga   3240

attatatgaa gtcaggtttg tttttttttt tttttttttt tcaaagcaca gtactgttag   3300

ctgtttttgt ggacaggatt cgattaagta ttccctcttg tcaaactgga agctagggga   3360

aaaagaggga tttttatcct ttactcttct agagtactgt taatgcccct ttcccacagt   3420

cttttatata attaaatata tgtcaataca cattagaatc agatttgaaa aagttaaaac   3480

aatttcattg ttgtaattgt tccctttctg ttttcatata gtgaataacc tttaaagggt   3540

tgttttgttt tgttttgaat tataggagtt ataatctttg gagatgattg catatctcat   3600

tagatatgca atataaattt atctgagtga acaaagtgct aaataaatag atctacattt   3660

tgtacatatt tatataaaat ttacctttaa gtatttactt taaaaaattt aatggcttaa   3720

ctcgaacttg aagacacata cttcaactgt ccttattgtc cattaaactg ataattttga   3780

tttttcttgc ttttatagat tttactatat aggaatcaag atttaagaaa ttttgcatta   3840

aaaatagtgt accaatgctt catatacgtt agttatttgc tattatgtag ggaagaggat   3900

tgttatttca aagatatatt aaagaacagt tgcatctgaa tataatcatg atgcattcaa   3960

tgaagttcat atccatgaat tcactcctaa tataccctaa taaagtggtt ga           4012


<210>  8
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Pro Ser Gly Pro Gly Ser Ser Ala Arg Arg Arg Cys Arg Arg 
1               5                   10                  15      


Val Leu Tyr Trp Ile Pro Val Val Phe Ile Thr Leu Leu Leu Gly Trp 
            20                  25                  30          


Ser Tyr Tyr Ala Tyr Ala Ile Gln Leu Cys Ile Val Ser Met Glu Asn 
        35                  40                  45              


Thr Gly Glu Gln Val Val Cys Leu Met Ala Tyr His Leu Leu Phe Ala 
    50                  55                  60                  


Met Phe Val Trp Ser Tyr Trp Lys Thr Ile Phe Thr Leu Pro Met Asn 
65                  70                  75                  80  


Pro Ser Lys Glu Phe His Leu Ser Tyr Ala Glu Lys Asp Leu Leu Glu 
                85                  90                  95      


Arg Glu Pro Arg Gly Glu Ala His Gln Glu Val Leu Arg Arg Ala Ala 
            100                 105                 110         


Lys Asp Leu Pro Ile Tyr Thr Arg Thr Met Ser Gly Ala Ile Arg Tyr 
        115                 120                 125             


Cys Asp Arg Cys Gln Leu Ile Lys Pro Asp Arg Cys His His Cys Ser 
    130                 135                 140                 


Val Cys Asp Lys Cys Ile Leu Lys Met Asp His His Cys Pro Trp Val 
145                 150                 155                 160 


Asn Asn Cys Val Gly Phe Ser Asn Tyr Lys Phe Phe Leu Leu Phe Leu 
                165                 170                 175     


Ala Tyr Ser Leu Leu Tyr Cys Leu Phe Ile Ala Ala Thr Asp Leu Gln 
            180                 185                 190         


Tyr Phe Ile Lys Phe Trp Thr Asn Gly Leu Pro Asp Thr Gln Ala Lys 
        195                 200                 205             


Phe His Ile Met Phe Leu Phe Phe Ala Ala Ala Met Phe Ser Val Ser 
    210                 215                 220                 


Leu Ser Ser Leu Phe Gly Tyr His Cys Trp Leu Val Ser Lys Asn Lys 
225                 230                 235                 240 


Ser Thr Leu Glu Ala Phe Arg Ser Pro Val Phe Arg His Gly Thr Asp 
                245                 250                 255     


Lys Asn Gly Phe Ser Leu Gly Phe Ser Lys Asn Met Arg Gln Val Phe 
            260                 265                 270         


Gly Asp Glu Lys Lys Tyr Trp Leu Leu Pro Ile Phe Ser Ser Leu Gly 
        275                 280                 285             


Asp Gly Cys Ser Phe Pro Thr Cys Leu Val Asn Gln Asp Pro Glu Gln 
    290                 295                 300                 


Ala Ser Thr Pro Ala Gly Leu Asn Ser Thr Ala Lys Asn Leu Glu Asn 
305                 310                 315                 320 


His Gln Phe Pro Ala Lys Pro Leu Arg Glu Ser Gln Ser His Leu Leu 
                325                 330                 335     


Thr Asp Ser Gln Ser Trp Thr Glu Ser Ser Ile Asn Pro Gly Lys Cys 
            340                 345                 350         


Lys Ala Gly Met Ser Asn Pro Ala Leu Thr Met Glu Asn Glu Thr 
        355                 360                 365         


<210>  9
<211>  740
<212>  DNA
<213>  Artificial

<220>
<223>  Artifical Construct

<400>  9
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac     60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac    120

ggcaagctga ccctgaagct gatctgcacc accggcaagc tgcccgtgcc ctggcccacc    180

ctcgtgacca ccctgggcta cggcctgcag tgcttcgccc gctaccccga ccacatgaag    240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc    300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg    360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac    420

aagctggagt acaactacaa cagccacaac gtctatatca ccgccgacaa gcagaagaac    480

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc    540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac    600

tacctgagct accagtccaa gctgagcaaa gaccccaacg agaagcgcga tcacatggtc    660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa    720

ttacttgtac agctcgtcca                                                740


<210>  10
<211>  239
<212>  PRT
<213>  Artificial

<220>
<223>  Artifical Construct

<400>  10

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  11
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Arg Ser Pro Pro Ser Pro Arg Pro Glu Pro Pro Pro Arg Pro Pro 
1               5                   10                  15      


Cys Pro Arg Pro Asn Lys Gly Ala Pro Arg Ala Ala Thr Ala Pro Arg 
            20                  25                  30          


Ala Pro Arg Arg Arg Val Pro Thr Arg Arg Ala Ala Arg Met Thr Trp 
        35                  40                  45              


Arg Arg Ser Arg Arg Arg Arg Arg Ser Ser Arg Arg Arg Arg Pro Arg 
    50                  55                  60                  


Arg Thr Arg Ser Ser Thr Arg Ser Ser Thr Arg Arg Thr Arg Arg Thr 
65                  70                  75                  80  


Ala Arg Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Leu Gly Arg Ala 
                85                  90                  95      


Leu Asn Phe Leu Phe Tyr Leu Ala Leu Val Ala Ala Ala Ala Phe Ser 
            100                 105                 110         


Gly Trp Cys Val His His Val Leu Glu Glu Val Gln Gln Val Arg Arg 
        115                 120                 125             


Ser His Gln Asp Phe Ser Arg Gln Arg Glu Glu Leu Gly Gln Gly Leu 
    130                 135                 140                 


Gln Gly Val Glu Gln Lys Val Gln Ser Leu Gln Ala Thr Phe Gly Thr 
145                 150                 155                 160 


Phe Glu Ser Ile Leu Arg Ser Ser Gln His Lys Gln Asp Leu Thr Glu 
                165                 170                 175     


Lys Ala Val Lys Gln Gly Glu Ser Glu Val Ser Arg Ile Ser Glu Val 
            180                 185                 190         


Leu Gln Lys Leu Gln Asn Glu Ile Leu Lys Asp Leu Ser Asp Gly Ile 
        195                 200                 205             


His Val Val Lys Asp Ala Arg Glu Arg Asp Phe Thr Ser Leu Glu Asn 
    210                 215                 220                 


Thr Val Glu Glu Arg Leu Thr Glu Leu Thr Lys Ser Ile Asn Asp Asn 
225                 230                 235                 240 


Ile Ala Ile Phe Thr Glu Val Gln Lys Arg Ser Gln Lys Glu Ile Asn 
                245                 250                 255     


Asp Met Lys Ala Lys Val Ala Ser Leu Glu Glu Ser Glu Gly Asn Lys 
            260                 265                 270         


Gln Asp Leu Lys Ala Leu Lys Glu Ala Val Lys Glu Ile Gln Thr Ser 
        275                 280                 285             


Ala Lys Ser Arg Glu Trp Asp Met Glu Ala Leu Arg Ser Thr Leu Gln 
    290                 295                 300                 


Thr Met Glu Ser Asp Ile Tyr Thr Glu Val Arg Glu Leu Val Ser Leu 
305                 310                 315                 320 


Lys Gln Glu Gln Gln Ala Phe Lys Glu Ala Ala Asp Thr Glu Arg Leu 
                325                 330                 335     


Ala Leu Gln Ala Leu Thr Glu Lys Leu Leu Arg Ser Glu Glu Ser Val 
            340                 345                 350         


Ser Arg Leu Pro Glu Glu Ile Arg Arg Leu Glu Glu Glu Leu Arg Gln 
        355                 360                 365             


Leu Lys Ser Asp Ser His Gly Pro Lys Glu Asp Gly Gly Phe Arg His 
    370                 375                 380                 


Ser Glu Ala Phe Glu Ala Leu Gln Gln Lys Ser Gln Gly Leu Asp Ser 
385                 390                 395                 400 


Arg Leu Gln His Val Glu Asp Gly Val Leu Ser Met Gln Val Ala Ser 
                405                 410                 415     


Ala Arg Gln Thr Glu Ser Leu Glu Ser Leu Leu Ser Lys Ser Gln Glu 
            420                 425                 430         


His Glu Gln Arg Leu Ala Ala Leu Gln Gly Arg Leu Glu Gly Leu Gly 
        435                 440                 445             


Ser Ser Glu Ala Asp Gln Asp Gly Leu Ala Ser Thr Val Arg Ser Leu 
    450                 455                 460                 


Gly Glu Thr Gln Leu Val Leu Tyr Gly Asp Val Glu Glu Leu Lys Arg 
465                 470                 475                 480 


Ser Val Gly Glu Leu Pro Ser Thr Val Glu Ser Leu Gln Lys Val Gln 
                485                 490                 495     


Glu Gln Val His Thr Leu Leu Ser Gln Asp Gln Ala Gln Ala Ala Arg 
            500                 505                 510         


Leu Pro Pro Gln Asp Phe Leu Asp Arg Leu Ser Ser Leu Asp Asn Leu 
        515                 520                 525             


Lys Ala Ser Val Ser Gln Val Glu Ala Asp Leu Lys Met Leu Arg Thr 
    530                 535                 540                 


Ala Val Asp Ser Leu Val Ala Tyr Ser Val Lys Ile Glu Thr Asn Glu 
545                 550                 555                 560 


Asn Asn Leu Glu Ser Ala Lys Gly Leu Leu Asp Asp Leu Arg Asn Asp 
                565                 570                 575     


Leu Asp Arg Leu Phe Val Lys Val Glu Lys Ile His Glu Lys Val 
            580                 585                 590     


<210>  12
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Ser Ala Lys Gln Arg Gly Ser Lys Gly Gly His Gly Ala Ala 
1               5                   10                  15      


Ser Pro Ser Glu Lys Gly Ala His Pro Ser Gly Gly Ala Asp Asp Gly 
            20                  25                  30          


Ala Gln Leu Ser Leu Leu Pro Arg Pro Ala Ala Ala Ala Phe Ser Gly 
        35                  40                  45              


Trp Cys Val His His Val Leu Glu Glu Val Gln Gln Val Arg Arg Ser 
    50                  55                  60                  


His Gln Asp Phe Ser Arg Gln Arg Glu Glu Leu Gly Gln Gly Leu Gln 
65                  70                  75                  80  


Gly Val Glu Gln Lys Val Gln Ser Leu Gln Ala Thr Phe Gly Thr Phe 
                85                  90                  95      


Glu Ser Ile Leu Arg Ser Ser Gln His Lys Gln Asp Leu Thr Glu Lys 
            100                 105                 110         


Ala Val Lys Gln Gly Glu Ser Glu Val Ser Arg Ile Ser Glu Val Leu 
        115                 120                 125             


Gln Lys Leu Gln Asn Glu Ile Leu Lys Asp Leu Ser Asp Gly Ile His 
    130                 135                 140                 


Val Val Lys Asp Ala Arg Glu Arg Asp Phe Thr Ser Leu Glu Asn Thr 
145                 150                 155                 160 


Val Glu Glu Arg Leu Thr Glu Leu Thr Lys Ser Ile Asn Asp Asn Ile 
                165                 170                 175     


Ala Ile Phe Thr Glu Val Gln Lys Arg Ser Gln Lys Glu Ile Asn Asp 
            180                 185                 190         


Met Lys Ala Lys Val Ala Ser Leu Glu Glu Ser Glu Gly Asn Lys Gln 
        195                 200                 205             


Asp Leu Lys Ala Leu Lys Glu Ala Val Lys Glu Ile Gln Thr Ser Ala 
    210                 215                 220                 


Lys Ser Arg Glu Trp Asp Met Glu Ala Leu Arg Ser Thr Leu Gln Thr 
225                 230                 235                 240 


Met Glu Ser Asp Ile Tyr Thr Glu Val Arg Glu Leu Val Ser Leu Lys 
                245                 250                 255     


Gln Glu Gln Gln Ala Phe Lys Glu Ala Ala Asp Thr Glu Arg Leu Ala 
            260                 265                 270         


Leu Gln Ala Leu Thr Glu Lys Leu Leu Arg Ser Glu Glu Ser Val Ser 
        275                 280                 285             


Arg Leu Pro Glu Glu Ile Arg Arg Leu Glu Glu Glu Leu Arg Gln Leu 
    290                 295                 300                 


Lys Ser Asp Ser His Gly Pro Lys Glu Asp Gly Gly Phe Arg His Ser 
305                 310                 315                 320 


Glu Ala Phe Glu Ala Leu Gln Gln Lys Ser Gln Gly Leu Asp Ser Arg 
                325                 330                 335     


Leu Gln His Val Glu Asp Gly Val Leu Ser Met Gln Val Ala Ser Ala 
            340                 345                 350         


Arg Gln Thr Glu Ser Leu Glu Ser Leu Leu Ser Lys Ser Gln Glu His 
        355                 360                 365             


Glu Gln Arg Leu Ala Ala Leu Gln Gly Arg Leu Glu Gly Leu Gly Ser 
    370                 375                 380                 


Ser Glu Ala Asp Gln Asp Gly Leu Ala Ser Thr Val Arg Ser Leu Gly 
385                 390                 395                 400 


Glu Thr Gln Leu Val Leu Tyr Gly Asp Val Glu Glu Leu Lys Arg Ser 
                405                 410                 415     


Val Gly Glu Leu Pro Ser Thr Val Glu Ser Leu Gln Lys Val Gln Glu 
            420                 425                 430         


Gln Val His Thr Leu Leu Ser Gln Asp Gln Ala Gln Ala Ala Arg Leu 
        435                 440                 445             


Pro Pro Gln Asp Phe Leu Asp Arg Leu Ser Ser Leu Asp Asn Leu Lys 
    450                 455                 460                 


Ala Ser Val Ser Gln Val Glu Ala Asp Leu Lys Met Leu Arg Thr Ala 
465                 470                 475                 480 


Val Asp Ser Leu Val Ala Tyr Ser Val Lys Ile Glu Thr Asn Glu Asn 
                485                 490                 495     


Asn Leu Glu Ser Ala Lys Gly Leu Leu Asp Asp Leu Arg Asn Asp Leu 
            500                 505                 510         


Asp Arg Leu Phe Val Lys Val Glu Lys Ile His Glu Lys Val 
        515                 520                 525     


<210>  13
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Ser Ala Lys Gln Arg Gly Ser Lys Gly Gly His Gly Ala Ala 
1               5                   10                  15      


Ser Pro Ser Glu Lys Gly Ala His Pro Ser Gly Gly Ala Asp Asp Val 
            20                  25                  30          


Ala Lys Lys Pro Pro Pro Ala Pro Gln Gln Pro Pro Pro Pro Pro Ala 
        35                  40                  45              


Pro His Pro Gln Gln His Pro Gln Gln His Pro Gln Asn Gln Ala His 
    50                  55                  60                  


Gly Lys Gly Gly His Arg Gly Gly Gly Gly Gly Gly Gly Lys Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser 
                85                  90                  95      


Ser Ala Ser Cys Ser Arg Arg Leu Gly Arg Ala Leu Asn Phe Leu Phe 
            100                 105                 110         


Tyr Leu Ala Leu Val Ala Ala Ala Ala Phe Ser Gly Trp Cys Val His 
        115                 120                 125             


His Val Leu Glu Glu Val Gln Gln Val Arg Arg Ser His Gln Asp Phe 
    130                 135                 140                 


Ser Arg Gln Arg Glu Glu Leu Gly Gln Gly Leu Gln Gly Val Glu Gln 
145                 150                 155                 160 


Lys Val Gln Ser Leu Gln Ala Thr Phe Gly Thr Phe Glu Ser Ile Leu 
                165                 170                 175     


Arg Ser Ser Gln His Lys Gln Asp Leu Thr Glu Lys Ala Val Lys Gln 
            180                 185                 190         


Gly Glu Ser Glu Val Ser Arg Ile Ser Glu Val Leu Gln Lys Leu Gln 
        195                 200                 205             


Asn Glu Ile Leu Lys Asp Leu Ser Asp Gly Ile His Val Val Lys Asp 
    210                 215                 220                 


Ala Arg Glu Arg Asp Phe Thr Ser Leu Glu Asn Thr Val Glu Glu Arg 
225                 230                 235                 240 


Leu Thr Glu Leu Thr Lys Ser Ile Asn Asp Asn Ile Ala Ile Phe Thr 
                245                 250                 255     


Glu Val Gln Lys Arg Ser Gln Lys Glu Ile Asn Asp Met Lys Ala Lys 
            260                 265                 270         


Val Ala Ser Leu Glu Glu Ser Glu Gly Asn Lys Gln Asp Leu Lys Ala 
        275                 280                 285             


Leu Lys Glu Ala Val Lys Glu Ile Gln Thr Ser Ala Lys Ser Arg Glu 
    290                 295                 300                 


Trp Asp Met Glu Ala Leu Arg Ser Thr Leu Gln Thr Met Glu Ser Asp 
305                 310                 315                 320 


Ile Tyr Thr Glu Val Arg Glu Leu Val Ser Leu Lys Gln Glu Gln Gln 
                325                 330                 335     


Ala Phe Lys Glu Ala Ala Asp Thr Glu Arg Leu Ala Leu Gln Ala Leu 
            340                 345                 350         


Thr Glu Lys Leu Leu Arg Ser Glu Glu Ser Val Ser Arg Leu Pro Glu 
        355                 360                 365             


Glu Ile Arg Arg Leu Glu Glu Glu Leu Arg Gln Leu Lys Ser Asp Ser 
    370                 375                 380                 


His Gly Pro Lys Glu Asp Gly Gly Phe Arg His Ser Glu Ala Phe Glu 
385                 390                 395                 400 


Ala Leu Gln Gln Lys Ser Gln Gly Leu Asp Ser Arg Leu Gln His Val 
                405                 410                 415     


Glu Asp Gly Val Leu Ser Met Gln Val Ala Ser Ala Arg Gln Thr Glu 
            420                 425                 430         


Ser Leu Glu Ser Leu Leu Ser Lys Ser Gln Glu His Glu Gln Arg Leu 
        435                 440                 445             


Ala Ala Leu Gln Gly Arg Leu Glu Gly Leu Gly Ser Ser Glu Ala Asp 
    450                 455                 460                 


Gln Asp Gly Leu Ala Ser Thr Val Arg Ser Leu Gly Glu Thr Gln Leu 
465                 470                 475                 480 


Val Leu Tyr Gly Asp Val Glu Glu Leu Lys Arg Ser Val Gly Glu Leu 
                485                 490                 495     


Pro Ser Thr Val Glu Ser Leu Gln Lys Val Gln Glu Gln Val His Thr 
            500                 505                 510         


Leu Leu Ser Gln Asp Gln Ala Gln Ala Ala Arg Leu Pro Pro Gln Asp 
        515                 520                 525             


Phe Leu Asp Arg Leu Ser Ser Leu Asp Asn Leu Lys Ala Ser Val Ser 
    530                 535                 540                 


Gln Val Glu Ala Asp Leu Lys Met Leu Arg Thr Ala Val Asp Ser Leu 
545                 550                 555                 560 


Val Ala Tyr Ser Val Lys Ile Glu Thr Asn Glu Asn Asn Leu Glu Ser 
                565                 570                 575     


Ala Lys Gly Leu Leu Asp Asp Leu Arg Asn Asp Leu Asp Arg Leu Phe 
            580                 585                 590         


Val Lys Val Glu Lys Ile His Glu Lys Val 
        595                 600         


<210>  14
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Ser Ala Lys Gln Arg Gly Ser Lys Gly Gly His Gly Ala Ala 
1               5                   10                  15      


Ser Pro Ser Glu Lys Gly Ala His Pro Ser Gly Gly Ala Asp Asp Val 
            20                  25                  30          


Ala Lys Lys Pro Pro Pro Ala Pro Gln Gln Pro Pro Pro Pro Pro Ala 
        35                  40                  45              


Pro His Pro Gln Gln His Pro Gln Gln His Pro Gln Asn Gln Ala His 
    50                  55                  60                  


Gly Lys Gly Gly His Arg Gly Gly Gly Gly Gly Gly Gly Lys Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser 
                85                  90                  95      


Ser Ala Ser Cys Ser Arg Arg Leu Gly Arg Ala Leu Asn Phe Leu Phe 
            100                 105                 110         


Tyr Leu Ala Leu Val Ala Ala Ala Ala Phe Ser Gly Trp Cys Val His 
        115                 120                 125             


His Val Leu Glu Glu Val Gln Gln Val Arg Arg Ser His Gln Asp Phe 
    130                 135                 140                 


Ser Arg Gln Arg Glu Glu Leu Gly Gln Gly Leu Gln Gly Val Glu Gln 
145                 150                 155                 160 


Lys Val Gln Ser Leu Gln Ala Thr Phe Gly Thr Phe Glu Ser Ile Leu 
                165                 170                 175     


Arg Ser Ser Gln His Lys Gln Asp Leu Thr Glu Lys Ala Val Lys Gln 
            180                 185                 190         


Gly Glu Ser Glu Val Ser Arg Ile Ser Glu Val Leu Gln Lys Leu Gln 
        195                 200                 205             


Asn Glu Ile Leu Lys Asp Leu Ser Asp Gly Ile His Val Val Lys Asp 
    210                 215                 220                 


Ala Arg Glu Arg Asp Phe Thr Ser Leu Glu Asn Thr Val Glu Glu Arg 
225                 230                 235                 240 


Leu Thr Glu Leu Thr Lys Ser Ile Asn Asp Asn Ile Ala Ile Phe Thr 
                245                 250                 255     


Glu Ser Leu Leu Ser Lys Ser Gln Glu His Glu Gln Arg Leu Ala Ala 
            260                 265                 270         


Leu Gln Gly Arg Leu Glu Gly Leu Gly Ser Ser Glu Ala Asp Gln Asp 
        275                 280                 285             


Gly Leu Ala Ser Thr Val Arg Ser Leu Gly Glu Thr Gln Leu Val Leu 
    290                 295                 300                 


Tyr Gly Asp Val Glu Glu Leu Lys Arg Ser Val Gly Glu Leu Pro Ser 
305                 310                 315                 320 


Thr Val Glu Ser Leu Gln Lys Val Gln Glu Gln Val His Thr Leu Leu 
                325                 330                 335     


Ser Gln Asp Gln Ala Gln Ala Ala Arg Leu Pro Pro Gln Asp Phe Leu 
            340                 345                 350         


Asp Arg Leu Ser Ser Leu Asp Asn Leu Lys Ala Ser Val Ser Gln Val 
        355                 360                 365             


Glu Ala Asp Leu Lys Met Leu Arg Thr Ala Val Asp Ser Leu Val Ala 
    370                 375                 380                 


Tyr Ser Val Lys Ile Glu Thr Asn Glu Asn Asn Leu Glu Ser Ala Lys 
385                 390                 395                 400 


Gly Leu Leu Asp Asp Leu Arg Asn Asp Leu Asp Arg Leu Phe Val Lys 
                405                 410                 415     


Val Glu Lys Ile His Glu Lys Val 
            420                 


<210>  15
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Pro Ser Ala Lys Gln Arg Gly Ser Lys Gly Gly His Gly Ala Ala 
1               5                   10                  15      


Ser Pro Ser Glu Lys Gly Ala His Pro Ser Gly Gly Ala Asp Asp Val 
            20                  25                  30          


Ala Lys Lys Pro Pro Pro Ala Pro Gln Gln Pro Pro Pro Pro Pro Ala 
        35                  40                  45              


Pro His Pro Gln Gln His Pro Gln Gln His Pro Arg Asn Gln Ala His 
    50                  55                  60                  


Gly Lys Gly Gly His Arg Gly Gly Gly Gly Gly Gly Gly Lys Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser 
                85                  90                  95      


Ser Ala Ser Cys Ser Arg Arg Leu Gly Arg Ala Leu Asn Phe Leu Phe 
            100                 105                 110         


Tyr Leu Ala Leu Val Ala Ala Ala Ala Phe Ser Gly Trp Cys Val His 
        115                 120                 125             


His Val Leu Glu Glu Val Gln Gln Val Arg Arg Ser His Gln Asp Phe 
    130                 135                 140                 


Ser Arg Gln Arg Glu Glu Leu Gly Gln Gly Leu Gln Gly Val Glu Gln 
145                 150                 155                 160 


Lys Val Gln Ser Leu Gln Ala Thr Phe Gly Thr Phe Glu Ser Ile Leu 
                165                 170                 175     


Arg Ser Ser Gln His Lys Gln Asp Leu Thr Glu Lys Ala Val Lys Gln 
            180                 185                 190         


Gly Glu Ser Glu Val Ser Arg Ile Ser Glu Val Leu Gln Lys Leu Gln 
        195                 200                 205             


Asn Glu Ile Leu Lys Asp Leu Ser Asp Gly Ile His Val Val Lys Asp 
    210                 215                 220                 


Ala Arg Glu Arg Asp Phe Thr Ser Leu Glu Asn Thr Val Glu Glu Arg 
225                 230                 235                 240 


Leu Thr Glu Leu Thr Lys Ser Ile Asn Asp Asn Ile Ala Ile Phe Thr 
                245                 250                 255     


Glu Val Gln Lys Arg Ser Gln Lys Glu Ile Asn Asp Met Lys Ala Lys 
            260                 265                 270         


Val Ala Ser Leu Glu Glu Ser Glu Gly Asn Lys Gln Asp Leu Lys Ala 
        275                 280                 285             


Leu Lys Glu Ala Val Lys Glu Ile Gln Thr Ser Ala Lys Ser Arg Glu 
    290                 295                 300                 


Trp Asp Met Glu Ala Leu Arg Ser Thr Leu Gln Thr Met Glu Ser Asp 
305                 310                 315                 320 


Ile Tyr Thr Glu Val Arg Glu Leu Val Ser Leu Lys Gln Glu Gln Gln 
                325                 330                 335     


Ala Phe Lys Glu Ala Ala Asp Thr Glu Arg Leu Ala Leu Gln Ala Leu 
            340                 345                 350         


Thr Glu Lys Leu Leu Arg Ser Glu Glu Ser Val Ser Arg Leu Pro Glu 
        355                 360                 365             


Glu Ile Arg Arg Leu Glu Glu Glu Leu Arg Gln Leu Lys Ser Asp Ser 
    370                 375                 380                 


His Gly Pro Lys Glu Asp Gly Gly Phe Arg His Ser Glu Ala Phe Glu 
385                 390                 395                 400 


Ala Leu Gln Gln Lys Ser Gln Gly Leu Asp Ser Arg Leu Gln His Val 
                405                 410                 415     


Glu Asp Gly Val Leu Ser Met Gln Val Ala Ser Ala Arg Gln Thr Glu 
            420                 425                 430         


Ser Leu Glu Ser Leu Leu Ser Lys Ser Gln Glu His Glu Gln Arg Leu 
        435                 440                 445             


Ala Ala Leu Gln Gly Arg Leu Glu Gly Leu Gly Ser Ser Glu Ala Asp 
    450                 455                 460                 


Gln Asp Gly Leu Ala Ser Thr Val Arg Ser Leu Gly Glu Thr Gln Leu 
465                 470                 475                 480 


Val Leu Tyr Gly Asp Val Glu Glu Leu Lys Arg Ser Val Gly Glu Leu 
                485                 490                 495     


Pro Ser Thr Val Glu Ser Leu Gln Lys Val Gln Glu Gln Val His Thr 
            500                 505                 510         


Leu Leu Ser Gln Asp Gln Ala Gln Ala Ala Arg Leu Pro Pro Gln Asp 
        515                 520                 525             


Phe Leu Asp Arg Leu Ser Ser Leu Asp Asn Leu Lys Ala Ser Val Ser 
    530                 535                 540                 


Gln Val Glu Ala Asp Leu Lys Met Leu Arg Thr Ala Val Asp Ser Leu 
545                 550                 555                 560 


Val Ala Tyr Ser Val Lys Ile Glu Thr Asn Glu Asn Asn Leu Glu Ser 
                565                 570                 575     


Ala Lys Gly Leu Leu Asp Asp Leu Arg Asn Asp Leu Asp Arg Leu Phe 
            580                 585                 590         


Val Lys Val Glu Lys Ile His Glu Lys Val 
        595                 600         


<210>  16
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Ser Ala Lys Gln Arg Gly Ser Lys Gly Gly His Gly Ala Ala 
1               5                   10                  15      


Ser Pro Ser Glu Lys Gly Ala His Pro Ser Gly Gly Ala Asp Asp Val 
            20                  25                  30          


Ala Lys Lys Pro Pro Pro Ala Pro Gln Gln Pro Pro Pro Pro Pro Ala 
        35                  40                  45              


Pro His Pro Gln Gln His Pro Gln Gln His Pro Gln Asn Gln Ala His 
    50                  55                  60                  


Gly Lys Gly Gly His Arg Gly Gly Gly Gly Gly Gly Gly Lys Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser 
                85                  90                  95      


Ser Ala Ser Cys Ser Arg Arg Leu Gly Arg Ala Leu Asn Phe Leu Phe 
            100                 105                 110         


Tyr Leu Ala Leu Val Ala Ala Ala Ala Phe Ser Gly Trp Cys Val His 
        115                 120                 125             


His Val Leu Glu Glu Val Gln Gln Val Arg Arg Ser His Gln Asp Phe 
    130                 135                 140                 


Ser Arg Gln Arg Glu Glu Leu Gly Gln Gly Leu Gln Gly Val Glu Gln 
145                 150                 155                 160 


Lys Val Gln Ser Leu Gln Ala Thr Phe Gly Thr Phe Glu Ser Ile Leu 
                165                 170                 175     


Arg Ser Ser Gln His Lys Gln Asp Leu Thr Glu Lys Ala Val Lys Gln 
            180                 185                 190         


Gly Glu Ser Glu Val Ser Arg Ile Ser Glu Val Leu Gln Lys Leu Gln 
        195                 200                 205             


Asn Glu Ile Leu Lys Asp Leu Ser Asp Gly Ile His Val Val Lys Asp 
    210                 215                 220                 


Ala Arg Glu Arg Asp Phe Thr Ser Leu Glu Asn Thr Val Glu Glu Arg 
225                 230                 235                 240 


Leu Thr Glu Leu Thr Lys Ser Ile Asn Asp Asn Ile Ala Ile Phe Thr 
                245                 250                 255     


Glu Val Gln Lys Arg Ser Gln Lys Glu Ile Asn Asp Met Lys Ala Lys 
            260                 265                 270         


Val Ala Ser Leu Glu Glu Ser Glu Gly Asn Lys Gln Asp Leu Lys Ala 
        275                 280                 285             


Leu Lys Glu Ala Val Lys Glu Ile Gln Thr Ser Ala Lys Ser Arg Glu 
    290                 295                 300                 


Trp Asp Met Glu Ala Leu Arg Ser Thr Leu Gln Thr Met Glu Ser Asp 
305                 310                 315                 320 


Ile Tyr Thr Glu Val Arg Glu Leu Val Ser Leu Lys Gln Glu Gln Gln 
                325                 330                 335     


Ala Phe Lys Glu Ala Ala Asp Thr Glu Arg Leu Ala Leu Gln Ala Leu 
            340                 345                 350         


Thr Glu Lys Leu Leu Arg Ser Glu Glu Ser Val Ser Arg Leu Pro Glu 
        355                 360                 365             


Glu Ile Arg Arg Leu Glu Glu Glu Leu Arg Gln Leu Lys Ser Asp Ser 
    370                 375                 380                 


His Gly Pro Lys Glu Asp Gly Gly Phe Arg His Ser Glu Ala Phe Glu 
385                 390                 395                 400 


Ala Leu Gln Gln Lys Ser Gln Gly Leu Asp Ser Arg Leu Gln His Val 
                405                 410                 415     


Glu Asp Gly Val Leu Ser Met Gln Val Ala Ser Ala Arg Gln Thr Glu 
            420                 425                 430         


Ser Leu Glu Ser Leu Leu Ser Lys Ser Gln Glu His Glu Gln Arg Leu 
        435                 440                 445             


Ala Ala Leu Gln Gly Arg Leu Glu Gly Leu Gly Ser Ser Glu Ala Asp 
    450                 455                 460                 


Gln Asp Gly Leu Ala Ser Thr Val Arg Ser Leu Gly Glu Thr Gln Leu 
465                 470                 475                 480 


Val Leu Tyr Gly Asp Val Glu Glu Leu Lys Arg Ser Val Gly Glu Leu 
                485                 490                 495     


Pro Ser Thr Val Glu Ser Leu Gln Lys Val Gln Glu Gln Val His Thr 
            500                 505                 510         


Leu Leu Ser Gln Asp Gln Ala Gln Ala Ala Arg Leu Pro Pro Gln Asp 
        515                 520                 525             


Phe Leu Asp Arg Leu Ser Ser Leu Asp Asn Leu Lys Ala Ser Val Ser 
    530                 535                 540                 


Gln Val Glu Ala Asp Leu Lys Met Leu Arg Thr Ala Val Asp Ser Leu 
545                 550                 555                 560 


Val Ala Tyr Ser Val Lys Ile Glu Thr Asn Glu Asn Asn Leu Glu Ser 
                565                 570                 575     


Ala Lys Gly Leu Leu Asp Asp Leu Arg Asn Asp Leu Asp Arg Leu Phe 
            580                 585                 590         


Val Lys Val Glu Lys Ile His Glu Lys Val 
        595                 600         


<210>  17
<211>  1809
<212>  DNA
<213>  Homo sapiens

<400>  17
atgccctcgg ccaaacaaag gggctccaag ggcggccacg gcgccgcgag cccctcggag     60

aagggtgccc acccgtcggg cggcgcggat gacgtggcga agaagccgcc gccggcgccg    120

cagcagccgc cgccgccgcc cgcgccgcac ccgcagcagc acccgcagca gcacccgcag    180

aaccaggcgc acggcaaggg cggccaccgc ggcggcggcg gcggcggcgg caagtcctcc    240

tcctcctcct ccgcctccgc cgccgctgcc gccgccgccg cctcgtcctc ggcgtcctgc    300

tcgcgcaggc tcggcagggc gctcaacttt ctcttctacc tcgccctggt ggcggcggcc    360

gctttctcgg gctggtgcgt ccaccacgtc ctggaggagg tccagcaggt ccggcgcagc    420

caccaggact tctcccggca gagggaggag ctgggccagg gcttgcaggg cgtcgagcag    480

aaggtgcagt ctttgcaagc cacatttgga acttttgagt ccatcttgag aagctcccaa    540

cataaacaag acctcacaga gaaagctgtg aagcaagggg agagtgaggt cagccggatc    600

agcgaagtgc tgcagaaact ccagaatgag attctcaaag acctctcgga tgggatccat    660

gtggtgaagg acgcccggga gcgggacttc acgtccctgg agaacacggt ggaggagcgg    720

ctgacggagc tcaccaaatc catcaacgac aacatcgcca tcttcacaga agtccagaag    780

aggagccaga aggagatcaa tgacatgaag gcaaaggttg cctccctgga agaatctgag    840

gggaacaagc aggatttgaa agccttaaag gaagctgtga aggagataca gacctcagcc    900

aagtccagag agtgggacat ggaggccctg agaagtaccc ttcagactat ggagtctgac    960

atctacaccg aggtccgcga gctggtgagc ctcaagcagg agcagcaggc tttcaaggag   1020

gcggccgaca cggagcggct cgccctgcag gccctcacgg agaagcttct caggtctgag   1080

gagtccgtct cccgcctccc ggaggagatc cggagactgg aggaagagct ccgccagctg   1140

aagtccgatt cccacgggcc gaaggaggac ggaggcttca gacactcgga agcctttgag   1200

gcactccagc aaaagagtca gggactggac tccaggctcc agcacgtgga ggatggggtg   1260

ctctccatgc aggtggcttc tgcgcgccag accgagagcc tggagtccct cctgtccaag   1320

agccaggagc acgagcagcg cctggccgcc ctgcaggggc gcctggaagg cctcgggtcc   1380

tcagaggcag accaggatgg cctggccagc acggtgagga gcctgggcga gacccagctg   1440

gtgctctacg gtgacgtgga ggagctgaag aggagtgtgg gcgagctccc cagcaccgtg   1500

gaatcactcc agaaggtgca ggagcaggtg cacacgctgc tcagtcagga ccaagcccag   1560

gccgcccgtc tgcctcctca ggacttcctg gacagacttt cttctctaga caacctgaaa   1620

gcctcagtca gccaagtgga ggcggacttg aaaatgctca ggactgctgt ggacagtttg   1680

gttgcatact cggtcaaaat agaaaccaac gagaacaatc tggaatcagc caagggttta   1740

ctagatgacc tgaggaatga tctggatagg ttgtttgtga aagtggagaa gattcacgaa   1800

aaggtctaa                                                           1809


<210>  18
<211>  1581
<212>  DNA
<213>  Homo sapiens

<400>  18
atgccctcgg ccaaacaaag gggctccaag ggcggccacg gcgccgcgag cccctcggag     60

aagggtgccc acccgtcggg cggcgcggat gacggcgctc aactttctct tctacctcgc    120

cctgcggcgg ccgctttctc gggctggtgc gtccaccacg tcctggagga ggtccagcag    180

gtccggcgca gccaccagga cttctcccgg cagagggagg agctgggcca gggcttgcag    240

ggcgtcgagc agaaggtgca gtctttgcaa gccacatttg gaacttttga gtccatcttg    300

agaagctccc aacataaaca agacctcaca gagaaagctg tgaagcaagg ggagagtgag    360

gtcagccgga tcagcgaagt gctgcagaaa ctccagaatg agattctcaa agacctctcg    420

gatgggatcc atgtggtgaa ggacgcccgg gagcgggact tcacgtccct ggagaacacg    480

gtggaggagc ggctgacgga gctcaccaaa tccatcaacg acaacatcgc catcttcaca    540

gaagtccaga agaggagcca gaaggagatc aatgacatga aggcaaaggt tgcctccctg    600

gaagaatctg aggggaacaa gcaggatttg aaagccttaa aggaagctgt gaaggagata    660

cagacctcag ccaagtccag agagtgggac atggaggccc tgagaagtac ccttcagact    720

atggagtctg acatctacac cgaggtccgc gagctggtga gcctcaagca ggagcagcag    780

gctttcaagg aggcggccga cacggagcgg ctcgccctgc aggccctcac ggagaagctt    840

ctcaggtctg aggagtccgt ctcccgcctc ccggaggaga tccggagact ggaggaagag    900

ctccgccagc tgaagtccga ttcccacggg ccgaaggagg acggaggctt cagacactcg    960

gaagcctttg aggcactcca gcaaaagagt cagggactgg actccaggct ccagcacgtg   1020

gaggatgggg tgctctccat gcaggtggct tctgcgcgcc agaccgagag cctggagtcc   1080

ctcctgtcca agagccagga gcacgagcag cgcctggccg ccctgcaggg gcgcctggaa   1140

ggcctcgggt cctcagaggc agaccaggat ggcctggcca gcacggtgag gagcctgggc   1200

gagacccagc tggtgctcta cggtgacgtg gaggagctga agaggagtgt gggcgagctc   1260

cccagcaccg tggaatcact ccagaaggtg caggagcagg tgcacacgct gctcagtcag   1320

gaccaagccc aggccgcccg tctgcctcct caggacttcc tggacagact ttcttctcta   1380

gacaacctga aagcctcagt cagccaagtg gaggcggact tgaaaatgct caggactgct   1440

gtggacagtt tggttgcata ctcggtcaaa atagaaacca acgagaacaa tctggaatca   1500

gccaagggtt tactagatga cctgaggaat gatctggata ggttgtttgt gaaagtggag   1560

aagattcacg aaaaggtcta a                                             1581


<210>  19
<211>  1776
<212>  DNA
<213>  Homo sapiens

<400>  19
gctcgctcgc ctcccagccc gcggcccgag ccgccgccgc gcccgccatg ccctcggcca     60

aacaaagggg ctccaagggc ggccacggcg ccgcgagccc ctcggagaag ggtgcccacc    120

cgtcgggcgg cgcggatgac gtggcgaaga agccgccgcc ggcgccgcag cagccgccgc    180

cgccgcccgc gccgcacccg cagcagcacc cgcagcagca cccgcagaac caggcgcacg    240

gcaagggcgg ccaccgcggc ggcggcggcg gcggcgctcg gcagggcgct caactttctc    300

ttctacctcg ccctggtggc ggcggccgct ttctcgggct ggtgcgtcca ccacgtcctg    360

gaggaggtcc agcaggtccg gcgcagccac caggacttct cccggcagag ggaggagctg    420

ggccagggct tgcagggcgt cgagcagaag gtgcagtctt tgcaagccac atttggaact    480

tttgagtcca tcttgagaag ctcccaacat aaacaagacc tcacagagaa agctgtgaag    540

caaggggaga gtgaggtcag ccggatcagc gaagtgctgc agaaactcca gaatgagatt    600

ctcaaagacc tctcggatgg gatccatgtg gtgaaggacg cccgggagcg ggacttcacg    660

tccctggaga acacggtgga ggagcggctg acggagctca ccaaatccat caacgacaac    720

atcgccatct tcacagaagt ccagaagagg agccagaagg agatcaatga catgaaggca    780

aaggttgcct ccctggaaga atctgagggg aacaagcagg atttgaaagc cttaaaggaa    840

gctgtgaagg agatacagac ctcagccaag tccagagagt gggacatgga ggccctgaga    900

agtacccttc agactatgga gtctgacatc tacaccgagg tccgcgagct ggtgagcctc    960

aagcaggagc agcaggcttt caaggaggcg gccgacacgg agcggctcgc cctgcaggcc   1020

ctcacggaga agcttctcag gtctgaggag tccgtctccc gcctcccgga ggagatccgg   1080

agactggagg aagagctccg ccagctgaag tccgattccc acgggccgaa ggaggacgga   1140

ggcttcagac actcggaagc ctttgaggca ctccagcaaa agagtcaggg actggactcc   1200

aggctccagc acgtggagga tggggtgctc tccatgcagg tggcttctgc gcgccagacc   1260

gagagcctgg agtccctcct gtccaagagc caggagcacg agcagcgcct ggccgccctg   1320

caggggcgcc tggaaggcct cgggtcctca gaggcagacc aggatggcct ggccagcacg   1380

gtgaggagcc tgggcgagac ccagctggtg ctctacggtg acgtggagga gctgaagagg   1440

agtgtgggcg agctccccag caccgtggaa tcactccaga aggtgcagga gcaggtgcac   1500

acgctgctca gtcaggacca agcccaggcc gcccgtctgc ctcctcagga cttcctggac   1560

agactttctt ctctagacaa cctgaaagcc tcagtcagcc aagtggaggc ggacttgaaa   1620

atgctcagga ctgctgtgga cagtttggtt gcatactcgg tcaaaataga aaccaacgag   1680

aacaatctgg aatcagccaa gggtttacta gatgacctga ggaatgatct ggataggttg   1740

tttgtgaaag tggagaagat tcacgaaaag gtctaa                             1776


<210>  20
<211>  2913
<212>  DNA
<213>  Homo sapiens

<400>  20
gggggagccc ctgcaagttt cccgggccgc gcgccgcgct cgctcgcctc ccagcccgcg     60

gcccgagccg ccgccgcgcc cgccatgccc tcggccaaac aaaggggctc caagggcggc    120

cacggcgccg cgagcccctc ggagaagggt gcccacccgt cgggcggcgc ggatgacgtg    180

gcgaagaagc cgccgccggc gccgcagcag ccgccgccgc cgcccgcgcc gcacccgcag    240

cagcacccgc agcagcaccc gcagaaccag gcgcacggca agggcggcca ccgcggcggc    300

ggcggcggcg gcggcaagtc ctcctcctcc tcctccgcct ccgccgccgc tgccgccgcc    360

gccgcctcgt cctcggcgtc ctgctcgcgc aggctcggca gggcgctcaa ctttctcttc    420

tacctcgccc tggtggcggc ggccgctttc tcgggctggt gcgtccacca cgtcctggag    480

gaggtccagc aggtccggcg cagccaccag gacttctccc ggcagaggga ggagctgggc    540

cagggcttgc agggcgtcga gcagaaggtg cagtctttgc aagccacatt tggaactttt    600

gagtccatct tgagaagctc ccaacataaa caagacctca cagagaaagc tgtgaagcaa    660

ggggagagtg aggtcagccg gatcagcgaa gtgctgcaga aactccagaa tgagattctc    720

aaagacctct cggatgggat ccatgtggtg aaggacgccc gggagcggga cttcacgtcc    780

ctggagaaca cggtggagga gcggctgacg gagctcacca aatccatcaa cgacaacatc    840

gccatcttca cagaagtcca gaagaggagc cagaaggaga tcaatgacat gaaggcaaag    900

gttgcctccc tggaagaatc tgaggggaac aagcaggatt tgaaagcctt aaaggaagct    960

gtgaaggaga tacagacctc agccaagtcc agagagtggg acatggaggc cctgagaagt   1020

acccttcaga ctatggagtc tgacatctac accgaggttc gcgagctggt gagcctcaag   1080

caggagcagc aggctttcaa ggaggcggcc gacacggagc ggctcgccct gcaggccctc   1140

acggagaagc ttctcaggtc tgaggagtcc gtctcccgcc tcccggagga gatccggaga   1200

ctggaggaag agctccgcca gctgaagtcc gattcccacg ggccgaagga ggacggaggc   1260

ttcagacact cggaagcctt tgaggcactc cagcaaaaga gtcagggact ggactccagg   1320

ctccagcacg tggaggatgg ggtgctctcc atgcaggtgg cttctgcgcg ccagaccgag   1380

agcctggagt ccctcctgtc caagagccag gagcacgagc agcgcctggc cgccctgcag   1440

gggcgcctgg aaggcctcgg gtcctcagag gcagaccagg atggcctggc cagcacggtg   1500

aggagcctgg gcgagaccca gctggtgctc tacggtgacg tggaggagct gaagaggagt   1560

gtgggcgagc tccccagcac cgtggaatca ctccagaagg tgcaggagca ggtgcacacg   1620

ctgctcagtc aggaccaagc ccaggccgcc cgtctgcctc ctcaggactt cctggacaga   1680

ctttcttctc tagacaacct gaaagcctca gtcagccaag tggaggcgga cttgaaaatg   1740

ctcaggactg ctgtggacag tttggttgca tactcggtca aaatagaaac caacgagaac   1800

aatctggaat cagccaaggg tttactagat gacctgagga atgatctgga taggttgttt   1860

gtgaaagtgg agaagattca cgaaaaggtc taaatgaatt gcgtgtgcag ggcgcggatt   1920

taaagtccaa tttctcatga ccaaaaaatg tgtggttttt tcccatgtgt cccctacccc   1980

ccaatttctt gtcccctctt aaagagcagt tgtcaccacc tgaacaccaa ggcattgtat   2040

tttcatgccc agttaactta tttacaatat ttaagttctc tgcttctgca tttggttggt   2100

ttcctgaagc gcagcccctg tgaataacag gtggcttttc atggatgtct ctagtcagag   2160

aaaaatgata aaggcttaaa ttgaggatta acagaagcag attaacctca gaaatcctgt   2220

ctggctggca gatttcaagt aaaaaaaaaa aaaaggtggg ttggggggac ccttttcttt   2280

ctagttgtct ttaaggaaaa ttaattttac tttttttttt gttctggccg aaatttttat   2340

gagatatctc tcacttgtct tccactttga accggttaaa gctcatagct gtcagctctg   2400

aatgaggagg ggagaagccc ctgggtcttt ctttgaaagg aatccgctgc ttgagggctg   2460

cctccctcat ggtgtgcgtg tcgttctctt cctgacgcat ctgtgatatc agaggtaact   2520

atgcaaagca tccaggcggt tctgaatgtg aagcactaca cccagcagag tcccggtgcc   2580

ctctgtcccc actgccggcc catgtcctct ctccggaggt caccaaggaa tgcacaggtt   2640

tcgactacca gaaaggggag tccttgggtt ctttcaaaaa attcgtgagg agagctgtct   2700

acagtggaat agggggtctc cctggggaat gcaggccaag tccttttatt ttaacatgat   2760

gtccatgaag aggtttgccg tctgggcagc cctgtcggca aggagcgtgc atactgcgtt   2820

tgtgtaattg tttgctgtat ctcccttccc tctgagctgt attgttcttt aatggctgtc   2880

ttgcccttcc aaaaaaaatt gaaaaaaaaa aaa                                2913


<210>  21
<211>  2231
<212>  DNA
<213>  Homo sapiens

<400>  21
agccaatggg gctcgctcgc ctcccagccc gcggcccgag ccgccgccgc gcccgccatg     60

ccctcggcca aacaaagggg ctccaagggc ggccacggcg ccgcgagccc ctcggagaag    120

ggtgcccacc cgtcgggcgg cgcggatgac gtggcgaaga agccgccgcc ggcgccgcag    180

cagccgccgc cgccgcccgc gccgcacccg cagcagcacc cgcagcagca cccgcagaac    240

caggcgcacg gcaagggcgg ccaccgcggc ggcggcggcg gcggcggcaa gtcctcctcc    300

tcctcctccg cctccgccgc cgctgccgcc gccgccgcct cgtcctcggc gtcctgctcg    360

cgcaggctcg gcagggcgct caactttctc ttctacctcg ccctggtggc ggcggccgct    420

ttctcgggct ggtgcgtcca ccacgtcctg gaggaggtcc agcaggtccg gcgcagccac    480

caggacttct cccggcagag ggaggagctg ggccagggct tgcagggcgt cgagcagaag    540

gtgcagtctt tgcaagccac atttggaact tttgagtcca tcttgagaag ctcccaacat    600

aaacaagacc tcacagagaa agctgtgaag caaggggaga gtgaggtcag ccggatcagc    660

gaagtgctgc agaaactcca gaatgagatt ctcaaagacc tctcggatgg gatccatgtg    720

gtgaaggacg cccgggagcg ggacttcacg tccctggaga acacggtgga ggagcggctg    780

acggagctca ccaaatccat caacgacaac atcgccatct tcacagaagt ccagaagagg    840

agccagaagg agatcaatga catgaaggca aaggttgcct ccctggaaga atctgagggg    900

aacaagcagg atttgaaagc cttaaaggaa gctgtgaagg agatacagac ctcagccaag    960

tccagagagt gggacatgga ggccctgaga agtacccttc agactatgga gtctgacatc   1020

tacaccgagg tccgcgagct ggtgagcctc aagcaggagc agcaggcttt caaggaggcg   1080

gccgacacgg agcggctcgc cctgcaggcc ctcacggaga agcttctcag gtctgaggag   1140

tccgtctccc gcctcccgga ggagatccgg agactggagg aagagctccg ccagctgaag   1200

tccgattccc acgggccgaa ggaggacgga ggcttcagac actcggaagc ctttgaggca   1260

ctccagcaaa agagtcaggg actggactcc aggctccagc acgtggagga tggggtgctc   1320

tccatgcagg tggcttctgc gcgccagacc gagagcctgg agtccctcct gtccaagagc   1380

caggagcacg agcagcgcct ggccgccctg caggggcgcc tggaaggcct cgggtcctca   1440

gaggcagacc aggatggcct ggccagcacg gtgaggagcc tgggcgagac ccagctggtg   1500

ctctacggtg acgtggagga gctgaagagg agtgtgggcg agctccccag caccgtggaa   1560

tcactccaga aggtgcagga gcaggtgcac acgctgctca gtcaggacca agcccaggcc   1620

gcccgtctgc ctcctcagga cttcctggac agactttctt ctctagacaa cctgaaagcc   1680

tcagtcagcc aagtggaggc ggacttgaaa atgctcagga ctgctgtgga cagtttggtt   1740

gcatactcgg tcaaaataga aaccaacgag aacaatctgg aatcagccaa gggtttacta   1800

gatgacctga ggaatgatct ggataggttg tttgtgaaag tggagaagat tcacgaaaag   1860

gtctaaatga attgcgtgtg cagggcgcgg atttaaagtc caatttctca tgaccaaaaa   1920

atgtgtggtt ttttcccatg tgtcccctac cccccaattt cttgtcccct cttaaagagc   1980

agttgtcacc acctgaacac caaggcattg tattttcatg cccagttaac ttatttacaa   2040

tatttaagtt ctctgcttct gcatttggtt ggtttcctga agcgcagccc ctgtgaataa   2100

caggtggctt ttcatggatg tctctagtca gagaaaaatg ataaaggctt aaattgagga   2160

ttaacagaag cagattaacc tcagaaatcc tgtctggctg gcagatttca agtaaaaaaa   2220

aaaaaaaaaa a                                                        2231


<210>  22
<211>  2039
<212>  DNA
<213>  Homo sapiens

<400>  22
gcgtgccgct cgcccagtcc cgggggagcc cctgcaagtt tcccgggccg cgcgccgcgc     60

tcgctcgcct cccagcccgc ggcccgagcc gccgccgcgc ccgccatgcc ctcggccaaa    120

caaaggggct ccaagggcgg ccacggcgcc gcgagcccct cggagaaggg tgcccacccg    180

tcgggcggcg cggatgacgt ggcgaagaag ccgccgccgg cggccgcttt ctcgggctgg    240

tgcgtccacc acgtcctgga ggaggtccag caggtccggc gcagccacca ggacttctcc    300

cggcagaggg aggagctggg ccagggcttg cagggcgtcg agcagaaggt gcagtctttg    360

caagccacat ttggaacttt tgagtccatc ttgagaagct cccaacataa acaagacctc    420

acagagaaag ctgtgaagca aggggagagt gaggtcagcc ggatcagcga agtgctgcag    480

aaactccaga atgagattct caaagacctc tcggatggga tccatgtggt gaaggacgcc    540

cgggagcggg acttcacgtc cctggagaac acggtggagg agcggctgac ggagctcacc    600

aaatccatca acgacaacat cgccatcttc acagaagtcc agaagaggag ccagaaggag    660

atcaatgaca tgaaggcaaa ggttgcctcc ctggaagaat ctgaggggaa caagcaggat    720

ttgaaagcct taaaggaagc tgtgaaggag atacagacct cagccaagtc cagagagtgg    780

gacatggagg ccctgagaag tacccttcag actatggagt ctgacatcta caccgaggtc    840

cgcgagctgg tgagcctcaa gcaggagcag caggctttca aggaggcggc cgacacggag    900

cggctcgccc tgcaggccct cacggagaag cttctcaggt ctgaggagcc cgtctcccgc    960

ctcccggagg agatccggag actggaggaa gagctccgcc agctgaagtc cgattcccac   1020

gggccgaagg aggacggagg cttcagacac tcggaagcct ttgaggcact ccagcaaaag   1080

agtcagggac tggactccag gctccagcac gtggaggatg gggtgctctc catgcaggtg   1140

gcttctgcgc gccagaccga gagcctggag tccctcctgt ccaagagcca ggagcacgag   1200

cagcgcctgg ccgccctgca ggggcgcctg gaaggcctcg ggtcctcaga ggcagaccag   1260

gatggcctgg ccagcacggt gaggagcctg ggcgagaccc agctggtgct ctacggtgac   1320

gtggaggagc tgaagaggag tgtgggcgag ctccccagca ccgtggaatc actccagaag   1380

gtgcaggagc aggtgcacac gctgctcagt caggaccaag cccaggccgc ccgtctgcct   1440

cctcaggact tcctggacag actttcttct ctagacaacc tgaaagcctc agtcagccaa   1500

gtggaggcgg acttgaaaat gctcaggact gctgtggaca gtttggttgc atactcggtc   1560

aaaatagaaa ccaacgagaa caatctggaa tcagccaagg gtttactaga tgacctgagg   1620

aatgatctgg ataggttgtt tgtgaaagtg gagaagattc acgaaaaggt ctaaatgaat   1680

tgcgtgtgca gggcgcggat ttaaagtcca atttctcatg accaaaaaat gtgtggtttt   1740

ttcccatgtg tcccctaccc cccaatttct tgtcccctct taaagagcag ttgtcaccac   1800

ctgaacacca aggcattgta ttttcatgcc cagttaactt atttacaata tttaagttct   1860

ctgcttctgc atttggttgg tttcctgaag cgcagcccct gtgaataaca ggtggctttt   1920

catggatgtc tctagtcaga gaaaaatgat aaaggcttaa attgaggatt aacagaagca   1980

gattaacctc agaaatcctg tctggctggc agatttcaag taaaaaaaaa aaaaaaaaa    2039


