
                                SEQUENCE LISTING

<110> Merck Sharp & Dohme Corp.
      Ni, Yan
      Sitlani, Ayesha
      Pandit, Shilpa
      Lewis, Dale
      Shen, Xun
      Lobo, Sharon
      McCabe, Timothy
      Condra, Jon
      Cubbon, Rose

<120> PCSK9 IMMUNOASSAY
  

<130> MRL-ACV-00011

<150> 60/121,951          
<151> 2008-12-12  

<160> 16

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 633
<212> DNA
<213> Homo Sapien

<400> 1
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc 60
tcgtgtagcg gcgattctct tcgtgataag tatgttcatt ggtaccagca gaaacccggg 120
caggcgccag ttgttgtgat ttattatgat actaatcgtc cctcaggcat cccggaacgc 180
tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa 240
gacgaagcgg attattattg cgctgcttat actcgttcta tttatgtgtt tggcggcggc 300
acgaagttaa ccgttcttgg ccagccgaaa gccgcaccga gtgtgacgct gtttccgccg 360
agcagcgaag aattgcaggc gaacaaagcg accctggtgt gcctgattag cgacttttat 420
ccgggagccg tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc gggagtggag 480
accaccacac cctccaaaca aagcaacaac aagtacgcgg ccagcagcta tctgagcctg 540
acgcctgagc agtggaagtc ccacagaagc tacagctgcc aggtcacgca tgaggggagc 600
accgtggaaa aaaccgttgc gccgactgag gcc                              633

<210> 2
<211> 735
<212> DNA
<213> Homo Sapien

<400> 2
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg 60
agctgcgcgg cctccggatt taccttttct gatcattgga tgcattgggt gcgccaagcc 120
cctgggaagg gtctcgagtg ggtgagctat atcgattatt atggtagcaa tacccattat 180
gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat 240
ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtatgctt 300
tatggttgga attatggtgt ttttgattat tggggccaag gcaccctggt gacggttagc 360
tcagcgtcga ccaaaggtcc aagcgtgttt ccgctggctc cgagcagcaa aagcaccagc 420
ggcggcacgg ctgccctggg ctgcctggtt aaagattatt tcccggaacc agtcaccgtg 480
agctggaaca gcggggcgct gaccagcggc gtgcatacct ttccggcggt gctgcaaagc 540
agcggcctgt atagcctgag cagcgttgtg accgtgccga gcagcagctt aggcactcag 600
acctatattt gcaacgtgaa ccataaaccg agcaacacca aagtggataa aaaagtggaa 660
ccgaaaagcg aattcgagca gaagctgatc tctgaggagg atctgaacgg cgcgccgcac 720
catcatcacc atcac                                                  735

<210> 3
<211> 211
<212> PRT
<213> Homo Sapien

<400> 3
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asp Lys Tyr Val
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Tyr
        35                  40                  45              
Tyr Asp Thr Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Thr Arg Ser Ile Tyr Val
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala
            100                 105                 110         
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn
        115                 120                 125             
Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val
    130                 135                 140                 
Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu
145                 150                 155                 160 
Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser
                165                 170                 175     
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser
            180                 185                 190         
Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro
        195                 200                 205             
Thr Glu Ala
    210     


<210> 4
<211> 245
<212> PRT
<213> Homo Sapien

<400> 4
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Asp Tyr Tyr Gly Ser Asn Thr His Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Met Leu Tyr Gly Trp Asn Tyr Gly Val Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Glu
    210                 215                 220                 
Phe Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Pro His
225                 230                 235                 240 
His His His His His
                245 


<210> 5
<211> 636
<212> DNA
<213> Homo Sapien

<400> 5
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc 60
tcgtgtagcg gcgattctct tcgtgataag tatgttcatt ggtaccagca gaaacccggg 120
caggcgccag ttgttgtgat ttattatgat actaatcgtc cctcaggcat cccggaacgc 180
tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa 240
gacgaagcgg attattattg cgctgcttat actcgttcta tttatgtgtt tggcggcggc 300
acgaagttaa ccgttcttgg ccagcccaag gccaacccca ccgtgaccct gttcccccca 360
tcttctgagg agctgcaagc caacaaggcc accctggtgt gcctgatctc tgacttctac 420
cctggcgctg tgacagtggc ctggaaggct gatggctctc ctgtgaaggc tggcgtggag 480
accaccaagc catctaagca gtctaacaac aagtatgctg cctcttctta cctgtctctg 540
acccctgagc agtggaagag ccaccggtct tactcttgcc aggtgaccca tgagggctct 600
acagtggaga agacagtggc ccccacagag tgctct                           636

<210> 6
<211> 1341
<212> DNA
<213> Homo Sapien

<400> 6
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg 60
agctgcgcgg cctccggatt taccttttct gatcattgga tgcattgggt gcgccaagcc 120
cctgggaagg gtctcgagtg ggtgagctat atcgattatt atggtagcaa tacccattat 180
gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat 240
ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtatgctt 300
tatggttgga attatggtgt ttttgattat tggggccaag gcaccctggt gacggttagc 360
tcagcatcca ccaagggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc 420
gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg 480
tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc 540
tcaggactct actccctcag cagcgtggtg accgtgacct ccagcaactt tggcacgcag 600
acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag 660
cggaaatgct gcgtggagtg cccaccatgc ccagcacctc cagtggccgg accatcagtc 720
ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg 780
tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat 840
ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgttc 900
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag 960
tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaaaccaaa 1020
gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag 1080
aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag 1140
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccat gctggactcc 1200
gacggctcct tcttcctcta cagcaagcta accgtggaca agagcaggtg gcagcagggg 1260
aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc 1320
ctctccctgt ctcctggtaa a                                           1341

<210> 7
<211> 212
<212> PRT
<213> Homo Sapien

<400> 7
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asp Lys Tyr Val
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Tyr
        35                  40                  45              
Tyr Asp Thr Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Thr Arg Ser Ile Tyr Val
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Asn
            100                 105                 110         
Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn
        115                 120                 125             
Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val
    130                 135                 140                 
Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly Val Glu
145                 150                 155                 160 
Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser
                165                 170                 175     
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser
            180                 185                 190         
Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro
        195                 200                 205             
Thr Glu Cys Ser
    210         


<210> 8
<211> 447
<212> PRT
<213> Homo Sapien

<400> 8
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Asp Tyr Tyr Gly Ser Asn Thr His Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Met Leu Tyr Gly Trp Asn Tyr Gly Val Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Thr Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys
    210                 215                 220                 
Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
                325                 330                 335     
Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350         
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445         


<210> 9
<211> 645
<212> DNA
<213> Homo Sapien

<400> 9
gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc 60
ctgagctgca gagcgagcca gtctgttaat tctaattatc tggcttggta ccagcagaaa 120
ccaggtcaag caccgcgtct attaatttat ggtgcttctt ctcgtgcaac tggggtcccg 180
gcgcgtttta gcggctctgg atccggcacg gattttaccc tgaccattag cagcctggaa 240
cctgaagact ttgcggttta ttattgccag cagtggggtg atgttcctat tacctttggc 300
cagggtacga aagttgaaat taaacgtacg gtggctgctc cgagcgtgtt tatttttccg 360
ccgagcgatg aacaactgaa aagcggcacg gcgagcgtgg tgtgcctgct gaacaacttt 420
tatccgcgtg aagcgaaagt tcagtggaaa gtagacaacg cgctgcaaag cggcaacagc 480
caggaaagcg tgaccgaaca ggatagcaaa gatagcacct attctctgag cagcaccctg 540
accctgagca aagcggatta tgaaaaacat aaagtgtatg cgtgcgaagt gacccatcaa 600
ggtctgagca gcccggtgac taaatctttt aatcgtggcg aggcc                 645

<210> 10
<211> 714
<212> DNA
<213> Homo Sapien

<400> 10
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg 60
agctgcgcgg cctccggatt taccttttct gattattata tgcattgggt gcgccaagcc 120
cctgggaagg gtctcgagtg ggtgagcaat atctctggtt ctggtagcac tacctattat 180
gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat 240
ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggtatg 300
tttgattttt ggggccaagg caccctggtg acggttagct cagcgtcgac caaaggtcca 360
agcgtgtttc cgctggctcc gagcagcaaa agcaccagcg gcggcacggc tgccctgggc 420
tgcctggtta aagattattt cccggaacca gtcaccgtga gctggaacag cggggcgctg 480
accagcggcg tgcatacctt tccggcggtg ctgcaaagca gcggcctgta tagcctgagc 540
agcgttgtga ccgtgccgag cagcagctta ggcactcaga cctatatttg caacgtgaac 600
cataaaccga gcaacaccaa agtggataaa aaagtggaac cgaaaagcga attcgagcag 660
aagctgatct ctgaggagga tctgaacggc gcgccgcacc atcatcacca tcac       714

<210> 11
<211> 215
<212> PRT
<213> Homo Sapien

<400> 11
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Asn
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Gly Asp Val Pro
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Ala
    210                 215 


<210> 12
<211> 237
<212> PRT
<213> Homo Sapien

<400> 12
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Asn Ile Ser Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Gly Met Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
        195                 200                 205             
Lys Lys Val Glu Pro Lys Ser Glu Phe Glu Gln Lys Leu Ile Ser Glu
    210                 215                 220                 
Glu Asp Leu Asn Gly Ala Pro His His His His His His
225                 230                 235         


<210> 13
<211> 645
<212> DNA
<213> Homo Sapien

<400> 13
gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc 60
ctgagctgca gagcgagcca gtctgttaat tctaattatc tggcttggta ccagcagaaa 120
ccaggtcaag caccgcgtct attaatttat ggtgcttctt ctcgtgcaac tggggtcccg 180
gcgcgtttta gcggctctgg atccggcacg gattttaccc tgaccattag cagcctggaa 240
cctgaagact ttgcggttta ttattgccag cagtggggtg atgttcctat tacctttggc 300
cagggtacga aagttgaaat taaacgtacg gtggctgcac catctgtctt catcttcccg 360
ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 420
tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 480
caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 540
acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 600
ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                 645

<210> 14
<211> 1320
<212> DNA
<213> Homo Sapien

<400> 14
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg 60
agctgcgcgg cctccggatt taccttttct gattattata tgcattgggt gcgccaagcc 120
cctgggaagg gtctcgagtg ggtgagcaat atctctggtt ctggtagcac tacctattat 180
gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat 240
ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggtatg 300
tttgattttt ggggccaagg caccctggtg acggttagct cagcatccac caagggccca 360
tccgtcttcc ccctggcgcc ctgctccagg agcacctccg agagcacagc cgccctgggc 420
tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg 480
accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc 540
agcgtggtga ccgtgacctc cagcaacttt ggcacgcaga cctacacctg caacgtagat 600
cacaagccca gcaacaccaa ggtggacaag acagttgagc ggaaatgctg cgtggagtgc 660
ccaccatgcc cagcacctcc agtggccgga ccatcagtct tcctgttccc cccaaaaccc 720
aaggacactc tcatgatctc ccggacccct gaggtcacgt gcgtggtggt ggacgtgagc 780
caggaagacc ccgaggtcca gttcaactgg tacgtggatg gcgtggaggt gcataatgcc 840
aagacaaagc cgcgggagga gcagttcaac agcacgttcc gtgtggtcag cgtcctcacc 900
gtcctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtctc caacaaaggc 960
ctcccgtcct ccatcgagaa aaccatctcc aaaaccaaag ggcagccccg agagccacag 1020
gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc 1080
ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 1140
gagaacaact acaagaccac gcctcccatg ctggactccg acggctcctt cttcctctac 1200
agcaagctaa ccgtggacaa gagcaggtgg cagcagggga atgtcttctc atgctccgtg 1260
atgcatgagg ctctgcacaa ccactacaca cagaagagcc tctccctgtc tcctggtaaa 1320


<210> 15
<211> 215
<212> PRT
<213> Homo Sapien

<400> 15
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Asn
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Gly Asp Val Pro
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 16
<211> 440
<212> PRT
<213> Homo Sapien

<400> 16
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Asn Ile Ser Gly Ser Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Met Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val
            100                 105                 110         
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys
        115                 120                 125             
Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys
    130                 135                 140                 
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
145                 150                 155                 160 
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu
                165                 170                 175     
Tyr Ser Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr
            180                 185                 190         
Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val
        195                 200                 205             
Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro
    210                 215                 220                 
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
225                 230                 235                 240 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                245                 250                 255     
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
            260                 265                 270         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
        275                 280                 285             
Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
305                 310                 315                 320 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro
                325                 330                 335     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
            340                 345                 350         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
        355                 360                 365             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
    370                 375                 380                 
Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
385                 390                 395                 400 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
            420                 425                 430         
Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440 

