                         SEQUENCE LISTING

<110>  Firmenich SA
 
<120>  Method for producing beta-santalene

<130>  7530PRIOR

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  548
<212>  PRT
<213>  Santalum album

<400>  1

Met Ala Thr Asp Asn Asp Ser Ser Glu Asn Arg Arg Met Gly Asn Tyr 
1               5                   10                  15      


Lys Pro Ser Ile Trp Asn Tyr Asp Phe Leu Gln Ser Leu Ala Thr Arg 
            20                  25                  30          


His Asn Ile Met Glu Glu Arg His Leu Lys Leu Ala Glu Lys Leu Lys 
        35                  40                  45              


Gly Gln Val Lys Phe Met Phe Gly Ala Pro Met Glu Pro Leu Ala Lys 
    50                  55                  60                  


Leu Glu Leu Val Asp Val Val Gln Arg Leu Gly Leu Asn His Arg Phe 
65                  70                  75                  80  


Glu Thr Glu Ile Lys Glu Ala Leu Phe Ser Ile Tyr Lys Asp Glu Ser 
                85                  90                  95      


Asn Gly Trp Trp Phe Gly His Leu His Ala Thr Ser Leu Arg Phe Arg 
            100                 105                 110         


Leu Leu Arg Gln Cys Gly Leu Phe Ile Pro Gln Asp Val Phe Lys Thr 
        115                 120                 125             


Phe Gln Ser Lys Thr Gly Glu Phe Asp Met Lys Leu Cys Asp Asn Val 
    130                 135                 140                 


Lys Gly Leu Leu Ser Leu Tyr Glu Ala Ser Phe Leu Gly Trp Arg Asp 
145                 150                 155                 160 


Glu Asn Ile Leu Asp Glu Ala Lys Ala Phe Ala Thr Lys Tyr Leu Lys 
                165                 170                 175     


Asn Ala Trp Glu Asn Ile Ser Gln Lys Trp Leu Ala Lys Arg Val Lys 
            180                 185                 190         


His Ala Leu Ala Leu Pro Leu His Trp Arg Val Pro Arg Ile Glu Ala 
        195                 200                 205             


Arg Trp Phe Val Glu Ala Tyr Gly Glu Glu Glu Asn Met Asn Pro Thr 
    210                 215                 220                 


Leu Leu Lys Leu Ala Lys Leu Asp Phe Asn Met Val Gln Ser Ile His 
225                 230                 235                 240 


Gln Lys Glu Ile Gly Glu Leu Ala Arg Trp Trp Val Thr Thr Gly Leu 
                245                 250                 255     


Asp Lys Leu Ala Phe Ala Arg Asn Asn Leu Leu Gln Ser Tyr Met Trp 
            260                 265                 270         


Ser Cys Ala Ile Ala Ser Asp Pro Lys Phe Lys Leu Ala Arg Glu Thr 
        275                 280                 285             


Ile Val Glu Ile Gly Ser Val Leu Thr Val Val Asp Asp Ala Tyr Asp 
    290                 295                 300                 


Val Tyr Gly Ser Met Asp Glu Leu Asp Leu Tyr Thr Asn Ser Val Glu 
305                 310                 315                 320 


Arg Trp Ser Cys Thr Glu Ile Asp Lys Leu Pro Asn Thr Leu Lys Leu 
                325                 330                 335     


Ile Phe Met Ala Met Phe Asn Lys Thr Asn Glu Val Gly Leu Arg Val 
            340                 345                 350         


Gln His Glu Arg Gly Tyr Ser Gly Ile Thr Thr Phe Ile Lys Ala Trp 
        355                 360                 365             


Val Glu Gln Cys Lys Ser Tyr Gln Lys Glu Ala Arg Trp Tyr His Gly 
    370                 375                 380                 


Gly His Thr Pro Pro Leu Glu Glu Tyr Ser Leu Asn Gly Leu Val Ser 
385                 390                 395                 400 


Ile Gly Phe Pro Leu Leu Leu Ile Thr Gly Tyr Val Ala Ile Ala Glu 
                405                 410                 415     


Asn Glu Ala Ala Leu Asp Lys Val His Pro Leu Pro Asp Leu Leu His 
            420                 425                 430         


Tyr Ser Ser Leu Leu Ser Arg Leu Ile Asn Asp Met Gly Thr Ser Ser 
        435                 440                 445             


Asp Glu Leu Glu Arg Gly Asp Asn Leu Lys Ser Ile Gln Cys Tyr Met 
    450                 455                 460                 


Asn Gln Thr Gly Ala Ser Glu Lys Val Ala Arg Glu His Ile Lys Gly 
465                 470                 475                 480 


Ile Ile Glu Glu Asn Trp Lys Ile Leu Asn Glu Cys Cys Phe Asp Gln 
                485                 490                 495     


Ser Gln Phe Gln Glu Pro Phe Val Thr Phe Asn Leu Asn Ser Val Arg 
            500                 505                 510         


Gly Ser His Phe Phe Tyr Glu Phe Gly Asp Gly Phe Gly Val Thr Asn 
        515                 520                 525             


Ser Trp Thr Lys Val Asp Met Lys Ser Val Leu Ile Asp Pro Ile Pro 
    530                 535                 540                 


Leu Asp Glu Glu 
545             


<210>  2
<211>  1650
<212>  DNA
<213>  Santalum album

<400>  2
atggctaccg ataatgacag ctctgaaaac cgtcgtatgg gtaattacaa gccgtccatc       60

tggaactacg acttcctgca gtccctggct acccgccaca atatcatgga agagcgccac      120

ttgaaactgg cggagaaact gaaaggccag gtgaagttta tgtttggtgc cccgatggag      180

ccgctggcca aactggagct ggttgatgtt gttcagcgcc tgggtctgaa tcatcgcttc      240

gagacggaga ttaaggaggc cctgttcagc atctacaagg atgagagcaa cggttggtgg      300

tttggccacc tgcatgccac cagcctgcgt tttcgcctgc tgcgccagtg tggtctgttc      360

attccgcaag acgttttcaa gacgttccaa agcaagaccg gcgagttcga catgaaactg      420

tgcgacaacg tcaagggttt gctgagcctg tacgaggctt cctttctggg ctggcgtgac      480

gaaaatatcc tggacgaagc gaaagctttt gccacgaagt acctgaagaa cgcatgggaa      540

aacattagcc agaagtggct ggcgaaacgc gtgaagcatg cgttggcact gccgttgcac      600

tggcgtgtgc ctcgtattga agcacgctgg tttgttgagg cgtacggcga ggaggaaaat      660

atgaatccga ccttgctgaa gctggctaag ttggatttta acatggtgca atctattcac      720

caaaaggaaa tcggtgaatt ggcacgttgg tgggtcacca ccggtctgga caaactggca      780

ttcgcgcgca ataatttgct gcaaagctac atgtggagct gcgcgatcgc atctgacccg      840

aagtttaagc tggctcgcga aaccatcgtg gagatcggtt ccgtgctgac tgttgtggat      900

gacgcctacg atgtttacgg tagcatggac gaactggact tgtataccaa tagcgtggag      960

cgttggagct gtacggaaat cgataagctg ccgaatacgc tgaaactgat ttttatggct     1020

atgtttaaca agaccaatga agttggtctg cgtgttcagc acgagcgtgg ttactccggc     1080

atcaccacct tcattaaggc atgggtcgaa cagtgtaaga gctatcaaaa agaagcgcgc     1140

tggtatcatg gtggtcacac gcctccgctg gaagagtact ccttgaatgg cttggtgagc     1200

attggtttcc cgctgctgct gattaccggc tacgtcgcca ttgccgaaaa cgaagcagcg     1260

ctggacaaag tgcatccgct gccggatctg ctgcactata gctctctgct gagccgcctg     1320

atcaacgaca tgggtacgag cagcgacgag ctggagcgcg gcgataatct gaaaagcatc     1380

caatgctata tgaatcagac cggcgcgagc gagaaggtgg cgcgcgagca catcaagggc     1440

atcattgagg agaattggaa gattctgaac gaatgttgct tcgaccaaag ccaatttcaa     1500

gagccgttcg tgacgttcaa cctgaacagc gttcgtggtt cccatttctt ttacgagttt     1560

ggtgacggtt tcggtgtgac gaatagctgg accaaggttg acatgaagag cgtcctgatt     1620

gatccgattc cactggatga agaataatga                                      1650


<210>  3
<211>  551
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide encoded by the optimized sequence SCH10-Ctg8201-opt 
       for expression in E. coli.

<400>  3

Met Ala Thr Leu Lys Thr Asp Thr Asp Ala Ser Glu Asn Arg Arg Met 
1               5                   10                  15      


Gly Asn Tyr Lys Pro Ser Ile Trp Asn Tyr Asp Phe Leu Gln Ser Leu 
            20                  25                  30          


Ala Thr His His Asn Ile Val Glu Glu Arg His Leu Lys Leu Ala Glu 
        35                  40                  45              


Lys Leu Lys Gly Gln Val Lys Phe Met Phe Gly Ala Pro Met Glu Pro 
    50                  55                  60                  


Leu Ala Lys Leu Glu Leu Val Asp Val Val Gln Arg Leu Gly Leu Asn 
65                  70                  75                  80  


His Leu Phe Glu Thr Glu Ile Lys Glu Ala Leu Phe Ser Ile Tyr Lys 
                85                  90                  95      


Asp Gly Ser Asn Gly Trp Trp Phe Gly His Leu His Ala Thr Ser Leu 
            100                 105                 110         


Arg Phe Arg Leu Leu Arg Gln Cys Gly Leu Phe Ile Pro Gln Asp Val 
        115                 120                 125             


Phe Lys Thr Phe Gln Asn Lys Thr Gly Glu Phe Asp Met Lys Leu Trp 
    130                 135                 140                 


Asp Asn Val Lys Gly Leu Leu Ser Leu Tyr Glu Ala Ser Tyr Leu Gly 
145                 150                 155                 160 


Trp Lys Gly Glu Asn Ile Leu Asp Glu Ala Lys Ala Phe Thr Thr Lys 
                165                 170                 175     


Cys Leu Lys Ser Ala Trp Glu Asn Ile Ser Glu Lys Trp Leu Ala Lys 
            180                 185                 190         


Arg Val Lys His Ala Leu Ala Leu Pro Leu His Trp Arg Val Pro Arg 
        195                 200                 205             


Ile Glu Ala Arg Trp Phe Ile Glu Val Tyr Glu Gln Glu Ala Asn Met 
    210                 215                 220                 


Asn Pro Thr Leu Leu Lys Leu Ala Lys Leu Asp Phe Asn Met Val Gln 
225                 230                 235                 240 


Ser Ile His Gln Lys Glu Ile Gly Glu Leu Ala Arg Trp Trp Val Thr 
                245                 250                 255     


Thr Gly Leu Asp Lys Leu Asp Phe Ala Arg Asn Asn Leu Leu Gln Ser 
            260                 265                 270         


Tyr Met Trp Ser Cys Ala Ile Ala Ser Asp Pro Lys Phe Lys Leu Ala 
        275                 280                 285             


Arg Glu Thr Ile Val Glu Ile Gly Ser Val Leu Thr Val Val Asp Asp 
    290                 295                 300                 


Gly Tyr Asp Val Tyr Gly Ser Met Asp Glu Leu Asp Leu Tyr Thr Ser 
305                 310                 315                 320 


Ser Val Glu Arg Trp Ser Cys Val Lys Ile Asp Lys Leu Pro Asn Thr 
                325                 330                 335     


Leu Lys Leu Ile Phe Met Ser Met Phe Asn Lys Thr Asn Glu Val Gly 
            340                 345                 350         


Leu Arg Val Gln His Glu Arg Gly Tyr Asn Ser Ile Pro Thr Phe Ile 
        355                 360                 365             


Lys Ala Trp Val Glu Gln Cys Lys Ser Tyr Gln Lys Glu Ala Arg Trp 
    370                 375                 380                 


Phe His Gly Gly His Thr Pro Pro Leu Glu Glu Tyr Ser Leu Asn Gly 
385                 390                 395                 400 


Leu Val Ser Ile Gly Phe Pro Leu Leu Leu Ile Thr Gly Tyr Val Ala 
                405                 410                 415     


Ile Ala Glu Asn Glu Ala Ala Leu Asp Lys Val His Pro Leu Pro Asp 
            420                 425                 430         


Leu Leu His Tyr Ser Ser Leu Leu Ser Arg Leu Ile Asn Asp Ile Gly 
        435                 440                 445             


Thr Ser Pro Asp Glu Met Ala Arg Gly Asp Asn Leu Lys Ser Ile His 
    450                 455                 460                 


Cys Tyr Met Asn Glu Thr Gly Ala Ser Glu Glu Val Ala Arg Glu His 
465                 470                 475                 480 


Ile Lys Gly Val Ile Glu Glu Asn Trp Lys Ile Leu Asn Gln Cys Cys 
                485                 490                 495     


Phe Asp Gln Ser Gln Phe Gln Glu Pro Phe Ile Thr Phe Asn Leu Asn 
            500                 505                 510         


Ser Val Arg Gly Ser His Phe Phe Tyr Glu Phe Gly Asp Gly Phe Gly 
        515                 520                 525             


Val Thr Asp Ser Trp Thr Lys Val Asp Met Lys Ser Val Leu Ile Asp 
    530                 535                 540                 


Pro Ile Pro Leu Gly Glu Glu 
545                 550     


<210>  4
<211>  1656
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Optimized sequence for expression in E. coli.

<400>  4
atggcaacct tgaagactga caccgacgct agcgagaatc gtcgcatggg caactataaa       60

ccgagcattt ggaactacga tttcctgcaa agcctggcta cccaccacaa tatcgtggag      120

gagcgtcacc tgaaactggc agaaaaattg aaaggccaag tgaaattcat gttcggcgca      180

ccgatggaac cgctggcgaa actggagctg gtcgacgtgg tccaacgcct gggtctgaat      240

cacctgtttg aaaccgaaat taaagaggca ctgttcagca tctataagga cggttcgaac      300

ggttggtggt tcggtcacct gcatgcaacc agcctgcgtt ttcgtctgct gcgtcagtgt      360

ggcctgttca ttccgcagga cgtctttaaa acctttcaga acaaaaccgg cgagtttgac      420

atgaagctgt gggacaatgt gaaaggcctg ttgagcctgt atgaggcgag ctacctgggt      480

tggaagggtg aaaacatcct ggatgaagca aaggcattta ccaccaagtg tctgaagagc      540

gcgtgggaaa atatctctga gaaatggttg gcgaaacgtg tgaagcacgc gctggcgctg      600

ccgctgcact ggcgcgttcc gcgcatcgaa gcgcgctggt ttatcgaagt ttatgaacag      660

gaagctaata tgaacccgac cctgctgaag ctggcgaagc tggatttcaa catggttcaa      720

agcattcatc aaaaggagat cggcgagctg gcccgctggt gggtgaccac gggtttggac      780

aagctggact ttgcacgtaa taatctgttg caaagctaca tgtggagctg cgctatcgca      840

tccgacccga aatttaagtt ggcacgtgaa accatcgttg aaattggtag cgtgctgact      900

gtggtggatg acggttacga tgtttacggt agcatggacg aactggacct gtacacgtcg      960

agcgtcgagc gctggagctg tgtcaaaatt gataagctgc cgaacacgct gaaactgatc     1020

ttcatgagca tgttcaacaa aaccaacgaa gtgggcctgc gcgtgcagca cgaacgtggc     1080

tataatagca ttccgacgtt tatcaaggca tgggtggagc aatgtaaaag ctaccaaaaa     1140

gaggcccgtt ggtttcatgg cggccatacc ccgcctctgg aggaatatag cctgaacggc     1200

ctggtgtcca ttggttttcc gctgctgctg atcaccggct acgtggcaat cgcggaaaat     1260

gaagccgcgc tggacaaggt ccatccactg ccggacctgt tgcattatag ctctctgctg     1320

agccgtctga tcaatgatat cggtacgagc ccggacgaga tggctcgtgg tgacaacctg     1380

aaaagcatcc attgttatat gaacgagacg ggtgcgtccg aagaggtcgc ccgcgagcat     1440

atcaagggcg ttattgagga gaactggaaa atcctgaatc aatgttgctt cgatcaaagc     1500

cagttccaag agccgttcat cacgttcaat ctgaacagcg ttcgcggtag ccactttttc     1560

tacgaatttg gcgacggttt tggcgttacg gacagctgga ccaaagttga tatgaaatcc     1620

gttctgatcg acccgatccc gttgggtgaa gagtag                               1656


<210>  5
<211>  1064
<212>  DNA
<213>  Santalum album

<400>  5
cccccgccat gagagctcca ttcattgatc atactgatca tgtgaatctc agaactgata       60

acgattcctc agagaatcga aggatgggga attataaacc cagtatttgg aactatgatt      120

ttttgcaatc gcttgcgact cgccacaata ttatggaaga gaggcatcta aagctagctg      180

agaagctgaa gggccaagtg aagtttatgt ttggggcacc aatggagccg ttagcaaagc      240

tggagcttgt ggatgtggtt caaaggctcg ggctaaacca ccgatttgag acagagatca      300

aggaagcgct atttagtatt tataaggatg agagcaatgg atggtggttt ggccacctcc      360

atgcgacatc tctccgattt aggctgctac gacagtgtgg gctttttatc ccccaggatg      420

tgtttaaaac atttcagagc aaaactggtg aatttgatat gaaactgtgt gacaatgtaa      480

aaggattgct gagcttgtat gaagcttcat tcttggggtg gagggatgaa aacatcttag      540

atgaagccaa agccttcgcc accaagtact tgaaaaatgc atgggaaaac atatcccaaa      600

agtggcttgc caaaagagtg aagcatgcac tggctttgcc tttgcactgg agagtcccta      660

gaatcgaagc tagatggttc gttgaggcat atggggaaga agagaatatg aacccaacac      720

ttctcaaact tgcaaaattg gactttaaca tggtgcaatc aattcatcag aaagagattg      780

gggaattagc gaggtggtgg gtgactacgg ggttggataa gttagcgttt gctaggaata      840

atttactgca aagctatatg tggagctgcg cgattgcttc cgacccaaag ttcaaacttg      900

ctagagaaac tattgttgaa atcggaagtg tactcacagt tgttgacgat gcatatgacg      960

tctatggttc aatggatgaa cttgatctct acacgaactc cgttgaaagg tggagctgta     1020

cagaaattga caagttacca aacacattaa aattgatttt tatg                      1064


<210>  6
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Primer synthesized on the basis of SCH5-Contig5.

<400>  6
cttcactctt ttggcaagcc acttttggg                                         29


<210>  7
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer synthesized on the basis of SCH5-Contig5.

<400>  7
gtggcgaagg ctttggcttc atctaagatg                                        30


<210>  8
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Primer synthesized on the basis of SCH5-Contig5

<400>  8
gcatatgacg tctatggttc aatggatgaa c                                      31


<210>  9
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer synthesized on the basis of SCH5-Contig5

<400>  9
gttgaaaggt ggagctgtac agaaattgac                                        30


<210>  10
<211>  610
<212>  DNA
<213>  Santalum album

<400>  10
acaaaataaa tctcttgttc tgttctttgg atctcgtttt cttcccctca gctctctcac       60

taatggattc ttccaccgcc accgccatga gagctccatt cattgatcat actgatcatg      120

tgaatctcag aactgataac gattcctcag agaatcgaag gatggggaat tataaaccca      180

gtatttggaa ctatgatttt ttgcaatcgc ttgcgactcg ccacaatatt atggaagaga      240

ggcatctaaa gctagctgag aagctgaagg gccaagtgaa gtttatgttt ggggcaccaa      300

tggagccgtt agcaaagctg gagcttgtgg atgtggttca aaggctcggg ctaaaccacc      360

gatttgagac agagatcaag gaagcgctat ttagtattta taaggatgag agcaatggat      420

ggtggtttgg ccacctccat gcgacatctc tccgatttag gctgctacga cagtgtgggc      480

tttttatccc ccaggatgtg tttaaaacat ttcagagcaa aactggtgaa tttgatatga      540

aactgtgtga caatgtaaaa ggattgctga gcttgtatga agcttcattc ttggggtgga      600

gggatgaaaa                                                             610


<210>  11
<211>  1049
<212>  DNA
<213>  Santalum album

<400>  11
caagttacca aacacattaa aattgatttt tatgtctatg tttaacaaga ccaatgaagt       60

tggccttcga gtccagcatg agcgaggcta cagtggcatc actactttta tcaaagcgtg      120

ggttgaacag tgtaaatcgt accagaaaga agcaagatgg taccatgggg gacacacgcc      180

tccactggaa gaatatagct tgaatggact ggtttccata ggattccctc tcttgttgat      240

cacaggctac gtggcaatcg ctgagaacga ggctgcactg gataaagtgc acccccttcc      300

tgatcttctg cactactcct ccctccttag tcgcctcatc aatgatatgg gaacctcttc      360

ggacgagttg gaaaggggag ataatctgaa gtcaattcaa tgttacatga accaaactgg      420

ggcttctgag aaagttgctc gtgagcacat aaagggaata atcgaggaaa actggaaaat      480

actgaatgag tgttgctttg atcaatctca gtttcaggag ccttttgtaa cattcaattt      540

gaactctgtt cgagggtctc atttcttcta cgaatttgga gatggctttg gggtgacgga      600

tagctggaca aaggttgata tgaagtctgt tttgatcgat cctattcctc tcgacgagga      660

gtagaaaact caaagcttgt gcttggttta cggtaatagt gattcagtat aaatataaaa      720

atcggacgaa cttgaggaat atgtgaggca taactatttt taatgatcat gagttaaata      780

attaagaaat atctattcgg ctcatgattc ttgagtatat attattcctt atgcgttata      840

tttccatcaa ataattagtc cgctcctgta agtcgactgt aacattactc taagggtcgc      900

tattggtttt atgttatatt aagtctacta gtttgaagtg atggaataaa tgtttgtttt      960

taagggggtt atgcactatg ttctcggttg ccttttacta ataaattttt tatgaaactc     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                       1049


<210>  12
<211>  2157
<212>  DNA
<213>  Santalum album

<400>  12
acaaaataaa tctcttgttc tgttctttgg atctcgtttt cttcccctca gctctctcac       60

taatggattc ttccaccgcc accgccatga gagctccatt cattgatcat actgatcatg      120

tgaatctcag aactgataac gattcctcag agaatcgaag gatggggaat tataaaccca      180

gtatttggaa ctatgatttt ttgcaatcgc ttgcgactcg ccacaatatt atggaagaga      240

ggcatctaaa gctagctgag aagctgaagg gccaagtgaa gtttatgttt ggggcaccaa      300

tggagccgtt agcaaagctg gagcttgtgg atgtggttca aaggctcggg ctaaaccacc      360

gatttgagac agagatcaag gaagcgctat ttagtattta taaggatgag agcaatggat      420

ggtggtttgg ccacctccat gcgacatctc tccgatttag gctgctacga cagtgtgggc      480

tttttatccc ccaggatgtg tttaaaacat ttcagagcaa aactggtgaa tttgatatga      540

aactgtgtga caatgtaaaa ggattgctga gcttgtatga agcttcattc ttggggtgga      600

gggatgaaaa catcttagat gaagccaaag ccttcgccac caagtacttg aaaaatgcat      660

gggaaaacat atcccaaaag tggcttgcca aaagagtgaa gcatgcactg gctttgcctt      720

tgcactggag agtccctaga atcgaagcta gatggttcgt tgaggcatat ggggaagaag      780

agaatatgaa cccaacactt ctcaaacttg caaaattgga ctttaacatg gtgcaatcaa      840

ttcatcagaa agagattggg gaattagcga ggtggtgggt gactacgggg ttggataagt      900

tagcgtttgc taggaataat ttactgcaaa gctatatgtg gagctgcgcg attgcttccg      960

acccaaagtt caaacttgct agagaaacta ttgttgaaat cggaagtgta ctcacagttg     1020

ttgacgatgc atatgacgtc tatggttcaa tggatgaact tgatctctac acgaactccg     1080

ttgaaaggtg gagctgtaca gaaattgaca agttaccaaa cacattaaaa ttgattttta     1140

tgtctatgtt taacaagacc aatgaagttg gccttcgagt ccagcatgag cgaggctaca     1200

gtggcatcac tacttttatc aaagcgtggg ttgaacagtg taaatcgtac cagaaagaag     1260

caagatggta ccatggggga cacacgcctc cactggaaga atatagcttg aatggactgg     1320

tttccatagg attccctctc ttgttgatca caggctacgt ggcaatcgct gagaacgagg     1380

ctgcactgga taaagtgcac ccccttcctg atcttctgca ctactcctcc ctccttagtc     1440

gcctcatcaa tgatatggga acctcttcgg acgagttgga aaggggagat aatctgaagt     1500

caattcaatg ttacatgaac caaactgggg cttctgagaa agttgctcgt gagcacataa     1560

agggaataat cgaggaaaac tggaaaatac tgaatgagtg ttgctttgat caatctcagt     1620

ttcaggagcc ttttgtaaca ttcaatttga actctgttcg agggtctcat ttcttctacg     1680

aatttggaga tggctttggg gtgacggata gctggacaaa ggttgatatg aagtctgttt     1740

tgatcgatcc tattcctctc gacgaggagt agaaaactca aagcttgtgc ttggtttacg     1800

gtaatagtga ttcagtataa atataaaaat cggacgaact tgaggaatat gtgaggcata     1860

actattttta atgatcatga gttaaataat taagaaatat ctattcggct catgattctt     1920

gagtatatat tattccttat gcgttatatt tccatcaaat aattagtccg ctcctgtaag     1980

tcgactgtaa cattactcta agggtcgcta ttggttttat gttatattaa gtctactagt     2040

ttgaagtgat ggaataaatg tttgttttta agggggttat gcactatgtt ctcggttgcc     2100

ttttactaat aaatttttta tgaaactcaa aaaaaaaaaa aaaaaaaaaa aaaaaaa        2157


<210>  13
<211>  569
<212>  PRT
<213>  Santalum album

<400>  13

Met Asp Ser Ser Thr Ala Thr Ala Met Arg Ala Pro Phe Ile Asp His 
1               5                   10                  15      


Thr Asp His Val Asn Leu Arg Thr Asp Asn Asp Ser Ser Glu Asn Arg 
            20                  25                  30          


Arg Met Gly Asn Tyr Lys Pro Ser Ile Trp Asn Tyr Asp Phe Leu Gln 
        35                  40                  45              


Ser Leu Ala Thr Arg His Asn Ile Met Glu Glu Arg His Leu Lys Leu 
    50                  55                  60                  


Ala Glu Lys Leu Lys Gly Gln Val Lys Phe Met Phe Gly Ala Pro Met 
65                  70                  75                  80  


Glu Pro Leu Ala Lys Leu Glu Leu Val Asp Val Val Gln Arg Leu Gly 
                85                  90                  95      


Leu Asn His Arg Phe Glu Thr Glu Ile Lys Glu Ala Leu Phe Ser Ile 
            100                 105                 110         


Tyr Lys Asp Glu Ser Asn Gly Trp Trp Phe Gly His Leu His Ala Thr 
        115                 120                 125             


Ser Leu Arg Phe Arg Leu Leu Arg Gln Cys Gly Leu Phe Ile Pro Gln 
    130                 135                 140                 


Asp Val Phe Lys Thr Phe Gln Ser Lys Thr Gly Glu Phe Asp Met Lys 
145                 150                 155                 160 


Leu Cys Asp Asn Val Lys Gly Leu Leu Ser Leu Tyr Glu Ala Ser Phe 
                165                 170                 175     


Leu Gly Trp Arg Asp Glu Asn Ile Leu Asp Glu Ala Lys Ala Phe Ala 
            180                 185                 190         


Thr Lys Tyr Leu Lys Asn Ala Trp Glu Asn Ile Ser Gln Lys Trp Leu 
        195                 200                 205             


Ala Lys Arg Val Lys His Ala Leu Ala Leu Pro Leu His Trp Arg Val 
    210                 215                 220                 


Pro Arg Ile Glu Ala Arg Trp Phe Val Glu Ala Tyr Gly Glu Glu Glu 
225                 230                 235                 240 


Asn Met Asn Pro Thr Leu Leu Lys Leu Ala Lys Leu Asp Phe Asn Met 
                245                 250                 255     


Val Gln Ser Ile His Gln Lys Glu Ile Gly Glu Leu Ala Arg Trp Trp 
            260                 265                 270         


Val Thr Thr Gly Leu Asp Lys Leu Ala Phe Ala Arg Asn Asn Leu Leu 
        275                 280                 285             


Gln Ser Tyr Met Trp Ser Cys Ala Ile Ala Ser Asp Pro Lys Phe Lys 
    290                 295                 300                 


Leu Ala Arg Glu Thr Ile Val Glu Ile Gly Ser Val Leu Thr Val Val 
305                 310                 315                 320 


Asp Asp Ala Tyr Asp Val Tyr Gly Ser Met Asp Glu Leu Asp Leu Tyr 
                325                 330                 335     


Thr Asn Ser Val Glu Arg Trp Ser Cys Thr Glu Ile Asp Lys Leu Pro 
            340                 345                 350         


Asn Thr Leu Lys Leu Ile Phe Met Ser Met Phe Asn Lys Thr Asn Glu 
        355                 360                 365             


Val Gly Leu Arg Val Gln His Glu Arg Gly Tyr Ser Gly Ile Thr Thr 
    370                 375                 380                 


Phe Ile Lys Ala Trp Val Glu Gln Cys Lys Ser Tyr Gln Lys Glu Ala 
385                 390                 395                 400 


Arg Trp Tyr His Gly Gly His Thr Pro Pro Leu Glu Glu Tyr Ser Leu 
                405                 410                 415     


Asn Gly Leu Val Ser Ile Gly Phe Pro Leu Leu Leu Ile Thr Gly Tyr 
            420                 425                 430         


Val Ala Ile Ala Glu Asn Glu Ala Ala Leu Asp Lys Val His Pro Leu 
        435                 440                 445             


Pro Asp Leu Leu His Tyr Ser Ser Leu Leu Ser Arg Leu Ile Asn Asp 
    450                 455                 460                 


Met Gly Thr Ser Ser Asp Glu Leu Glu Arg Gly Asp Asn Leu Lys Ser 
465                 470                 475                 480 


Ile Gln Cys Tyr Met Asn Gln Thr Gly Ala Ser Glu Lys Val Ala Arg 
                485                 490                 495     


Glu His Ile Lys Gly Ile Ile Glu Glu Asn Trp Lys Ile Leu Asn Glu 
            500                 505                 510         


Cys Cys Phe Asp Gln Ser Gln Phe Gln Glu Pro Phe Val Thr Phe Asn 
        515                 520                 525             


Leu Asn Ser Val Arg Gly Ser His Phe Phe Tyr Glu Phe Gly Asp Gly 
    530                 535                 540                 


Phe Gly Val Thr Asp Ser Trp Thr Lys Val Asp Met Lys Ser Val Leu 
545                 550                 555                 560 


Ile Asp Pro Ile Pro Leu Asp Glu Glu 
                565                 


<210>  14
<211>  1710
<212>  DNA
<213>  Santalum album

<400>  14
atggattctt ccaccgccac cgccatgaga gctccattca ttgatcatac tgatcatgtg       60

aatctcagaa ctgataacga ttcctcagag aatcgaagga tggggaatta taaacccagt      120

atttggaact atgatttttt gcaatcgctt gcgactcgcc acaatattat ggaagagagg      180

catctaaagc tagctgagaa gctgaagggc caagtgaagt ttatgtttgg ggcaccaatg      240

gagccgttag caaagctgga gcttgtggat gtggttcaaa ggctcgggct aaaccaccga      300

tttgagacag agatcaagga agcgctattt agtatttata aggatgagag caatggatgg      360

tggtttggcc acctccatgc gacatctctc cgatttaggc tgctacgaca gtgtgggctt      420

tttatccccc aggatgtgtt taaaacattt cagagcaaaa ctggtgaatt tgatatgaaa      480

ctgtgtgaca atgtaaaagg attgctgagc ttgtatgaag cttcattctt ggggtggagg      540

gatgaaaaca tcttagatga agccaaagcc ttcgccacca agtacttgaa aaatgcatgg      600

gaaaacatat cccaaaagtg gcttgccaaa agagtgaagc atgcactggc tttgcctttg      660

cactggagag tccctagaat cgaagctaga tggttcgttg aggcatatgg ggaagaagag      720

aatatgaacc caacacttct caaacttgca aaattggact ttaacatggt gcaatcaatt      780

catcagaaag agattgggga attagcgagg tggtgggtga ctacggggtt ggataagtta      840

gcgtttgcta ggaataattt actgcaaagc tatatgtgga gctgcgcgat tgcttccgac      900

ccaaagttca aacttgctag agaaactatt gttgaaatcg gaagtgtact cacagttgtt      960

gacgatgcat atgacgtcta tggttcaatg gatgaacttg atctctacac gaactccgtt     1020

gaaaggtgga gctgtacaga aattgacaag ttaccaaaca cattaaaatt gatttttatg     1080

gctatgttta acaagaccaa tgaagttggc cttcgagtcc agcatgagcg aggctacagc     1140

ggcatcacta cttttatcaa agcatgggtt gaacagtgta aatcgtacca gaaagaagca     1200

agatggtacc atgggggaca cacgcctcca ctggaagaat atagcttgaa tggacttgtt     1260

tccataggat tccctctctt gttgatcaca ggctacgtgg caatcgctga gaacgaggct     1320

gcactggata aagtgcaccc ccttcctgat cttctgcact actcctccct ccttagtcgc     1380

ctcatcaatg atatgggaac ctcttcggac gagttggaaa ggggagataa tctgaagtca     1440

attcaatgtt acatgaacca aactggggct tctgagaaag ttgctcgtga gcacataaag     1500

ggaataatcg aggaaaactg gaaaatactg aatgagtgtt gctttgatca atctcagttt     1560

caggagcctt ttgtaacatt caatttgaac tctgttcgag ggtctcattt cttctacgaa     1620

tttggagatg gctttggggt gacgaatagc tggacaaagg ttgatatgaa gtctgttttg     1680

atcgatccta ttcctctcga cgaggagtag                                      1710


<210>  15
<211>  569
<212>  PRT
<213>  Santalum album

<400>  15

Met Asp Ser Ser Thr Ala Thr Ala Met Arg Ala Pro Phe Ile Asp His 
1               5                   10                  15      


Thr Asp His Val Asn Leu Arg Thr Asp Asn Asp Ser Ser Glu Asn Arg 
            20                  25                  30          


Arg Met Gly Asn Tyr Lys Pro Ser Ile Trp Asn Tyr Asp Phe Leu Gln 
        35                  40                  45              


Ser Leu Ala Thr Arg His Asn Ile Met Glu Glu Arg His Leu Lys Leu 
    50                  55                  60                  


Ala Glu Lys Leu Lys Gly Gln Val Lys Phe Met Phe Gly Ala Pro Met 
65                  70                  75                  80  


Glu Pro Leu Ala Lys Leu Glu Leu Val Asp Val Val Gln Arg Leu Gly 
                85                  90                  95      


Leu Asn His Arg Phe Glu Thr Glu Ile Lys Glu Ala Leu Phe Ser Ile 
            100                 105                 110         


Tyr Lys Asp Glu Ser Asn Gly Trp Trp Phe Gly His Leu His Ala Thr 
        115                 120                 125             


Ser Leu Arg Phe Arg Leu Leu Arg Gln Cys Gly Leu Phe Ile Pro Gln 
    130                 135                 140                 


Asp Val Phe Lys Thr Phe Gln Ser Lys Thr Gly Glu Phe Asp Met Lys 
145                 150                 155                 160 


Leu Cys Asp Asn Val Lys Gly Leu Leu Ser Leu Tyr Glu Ala Ser Phe 
                165                 170                 175     


Leu Gly Trp Arg Asp Glu Asn Ile Leu Asp Glu Ala Lys Ala Phe Ala 
            180                 185                 190         


Thr Lys Tyr Leu Lys Asn Ala Trp Glu Asn Ile Ser Gln Lys Trp Leu 
        195                 200                 205             


Ala Lys Arg Val Lys His Ala Leu Ala Leu Pro Leu His Trp Arg Val 
    210                 215                 220                 


Pro Arg Ile Glu Ala Arg Trp Phe Val Glu Ala Tyr Gly Glu Glu Glu 
225                 230                 235                 240 


Asn Met Asn Pro Thr Leu Leu Lys Leu Ala Lys Leu Asp Phe Asn Met 
                245                 250                 255     


Val Gln Ser Ile His Gln Lys Glu Ile Gly Glu Leu Ala Arg Trp Trp 
            260                 265                 270         


Val Thr Thr Gly Leu Asp Lys Leu Ala Phe Ala Arg Asn Asn Leu Leu 
        275                 280                 285             


Gln Ser Tyr Met Trp Ser Cys Ala Ile Ala Ser Asp Pro Lys Phe Lys 
    290                 295                 300                 


Leu Ala Arg Glu Thr Ile Val Glu Ile Gly Ser Val Leu Thr Val Val 
305                 310                 315                 320 


Asp Asp Ala Tyr Asp Val Tyr Gly Ser Met Asp Glu Leu Asp Leu Tyr 
                325                 330                 335     


Thr Asn Ser Val Glu Arg Trp Ser Cys Thr Glu Ile Asp Lys Leu Pro 
            340                 345                 350         


Asn Thr Leu Lys Leu Ile Phe Met Ala Met Phe Asn Lys Thr Asn Glu 
        355                 360                 365             


Val Gly Leu Arg Val Gln His Glu Arg Gly Tyr Ser Gly Ile Thr Thr 
    370                 375                 380                 


Phe Ile Lys Ala Trp Val Glu Gln Cys Lys Ser Tyr Gln Lys Glu Ala 
385                 390                 395                 400 


Arg Trp Tyr His Gly Gly His Thr Pro Pro Leu Glu Glu Tyr Ser Leu 
                405                 410                 415     


Asn Gly Leu Val Ser Ile Gly Phe Pro Leu Leu Leu Ile Thr Gly Tyr 
            420                 425                 430         


Val Ala Ile Ala Glu Asn Glu Ala Ala Leu Asp Lys Val His Pro Leu 
        435                 440                 445             


Pro Asp Leu Leu His Tyr Ser Ser Leu Leu Ser Arg Leu Ile Asn Asp 
    450                 455                 460                 


Met Gly Thr Ser Ser Asp Glu Leu Glu Arg Gly Asp Asn Leu Lys Ser 
465                 470                 475                 480 


Ile Gln Cys Tyr Met Asn Gln Thr Gly Ala Ser Glu Lys Val Ala Arg 
                485                 490                 495     


Glu His Ile Lys Gly Ile Ile Glu Glu Asn Trp Lys Ile Leu Asn Glu 
            500                 505                 510         


Cys Cys Phe Asp Gln Ser Gln Phe Gln Glu Pro Phe Val Thr Phe Asn 
        515                 520                 525             


Leu Asn Ser Val Arg Gly Ser His Phe Phe Tyr Glu Phe Gly Asp Gly 
    530                 535                 540                 


Phe Gly Val Thr Asn Ser Trp Thr Lys Val Asp Met Lys Ser Val Leu 
545                 550                 555                 560 


Ile Asp Pro Ile Pro Leu Asp Glu Glu 
                565                 


<210>  16
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  16
ctagccatgg cttcagaaaa agaaattagg agag                                   34


<210>  17
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  17
ccggaattcc tatttgcttc tcttgtaaac tttgttcaag                             40


<210>  18
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  18
aaggagatat acatatgaca aaaaaagttg gtgtcggtca gg                          42


<210>  19
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  19
ctttaccaga ctcgagttac gcctttttca tctgatcctt tgc                         43


<210>  20
<211>  35
<212>  DNA
<213>  Primer

<400>  20
cccgggggat ccatggctac cgataatgac agctc                                  35


<210>  21
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  21
caccgctgag caataactag cat                                               23


<210>  22
<211>  383
<212>  DNA
<213>  Santalum album

<400>  22
gatcaaggaa gcgctgttta gtatttacaa ggatgggagc aatggatggt ggtttggcca       60

ccttcatgcg acatctctcc gatttaggct gctacgacag tgtgggcttt ttattcccca      120

agatgtgttt aaaacgttcc aaaacaaaac tggggaattt gatatgaaac tgtgggacaa      180

cgtaaaaggg ctgctgagct tatatgaagc ttcatacttg ggatggaagg gtgaaaacat      240

cctagatgaa gccaaggcct tcaccaccaa gtgcttgaaa agtgcatggg aaaatatatc      300

cgaaaagtgg ttagccaaaa gagtgaagca tgcattggct ttgcctttgc attggagagt      360

ccctcgaatc gaagctagat ggt                                              383


<210>  23
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  23
ccgaaaagtg gttagccaaa agagtg                                            26


<210>  24
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  24
cgggtcggaa gcaatcgcgc agc                                               23


<210>  25
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  25
ccgatttcga caatagtttc tctagc                                            26


<210>  26
<211>  1725
<212>  DNA
<213>  Santalum album

<400>  26
actaatggat tcttccaccg ccaccgccat gacagctcca ttcattgatc ctactgatca       60

tgtgaatctc aaaactgata ctgatgcctc agagaatcga aggatgggaa attataaacc      120

cagcatttgg aattatgatt ttttacaatc acttgcaact catcacaata ttgtggaaga      180

gaggcatcta aagctagctg agaagctgaa gggccaagtg aagtttatgt ttggggcacc      240

aatggagccg ttagcaaagc tggagcttgt ggatgtggtt caaaggcttg ggctaaacca      300

cctatttgag acagagatca aggaagcgct gtttagtatt tacaaggatg ggagcaatgg      360

atggtggttt ggccaccttc atgcgacatc tctccgattt aggctgctac gacagtgtgg      420

gctttttatt ccccaagatg tgtttaaaac gttccaaaac aaaactgggg aatttgatat      480

gaaactgtgg gacaacgtaa aagggctgct gagcttatat gaagcttcat acttgggatg      540

gaagggtgaa aacatcctag atgaagccaa ggccttcacc accaagtgct tgaaaagtgc      600

atgggaaaat atatccgaaa agtggttagc caaaagagtg aagcatgcat tggctttgcc      660

tttgcattgg agagtccctc gaatcgaagc tagatggttc attgaggtat atgagcaaga      720

agcgaatatg aacccaacac tactcaaact cgcaaaatta gactttaata tggtgcaatc      780

aattcatcag aaagagattg gggaattagc aaggtggtgg gtgactactg gcttggataa      840

gttagacttt gctaggaata atttactgca gagctatatg tggagctgcc cgattgcttc      900

cgacccgaag ttcaaacttg ctagagaaac tattgtcgaa atcggaagtg tactcacagt      960

tgttgacgat ggatatgacg tctatggttc aatggacgaa cttgatctct acacaagctc     1020

cgttgaaagg tggagctgtg tgaaaattga caagttgcca aacacgttaa aattaatttt     1080

tatgtctatg ttcaacaaga ccaatgaggt tggtcttcga gtccagcatg agcgaggcta     1140

caatagcatc cctactttta tcaaagcgtg ggttgaacag tgtaaatcat accagaaaga     1200

agcaagatgg ttccacgggg gacacacgcc tccattggaa gaatatagct tgaatggact     1260

tgtttccata ggattccctc tcttgttaat cacaggctac gtggcaatcg ctgagaacga     1320

ggctgcactg gataaagtgc acccccttcc tgatcttctg cactactcct ccctccttag     1380

tcgcctcatc aatgatatag gaacgtctcc ggatgagatg gcaagaggcg ataatctgaa     1440

gtcaatccat tgttacatga acgaaactgg ggcttccgag gaagttgctc gtgagcacat     1500

aaagggagta atcgaggaga attggaaaat actgaatcag tgctgctttg atcaatctca     1560

gtttcaggag ccttttataa ccttcaattt gaactctgtt cgagggtctc atttcttcta     1620

tgaatttggg gatggctttg gggtgacgga tagctggaca aaggttgata tgaagtccgt     1680

tttgatcgac cctattcctc tcggcgagga gtagtaagct cgaag                     1725


<210>  27
<211>  569
<212>  PRT
<213>  Santalum Album

<400>  27

Met Asp Ser Ser Thr Ala Thr Ala Met Thr Ala Pro Phe Ile Asp Pro 
1               5                   10                  15      


Thr Asp His Val Asn Leu Lys Thr Asp Thr Asp Ala Ser Glu Asn Arg 
            20                  25                  30          


Arg Met Gly Asn Tyr Lys Pro Ser Ile Trp Asn Tyr Asp Phe Leu Gln 
        35                  40                  45              


Ser Leu Ala Thr His His Asn Ile Val Glu Glu Arg His Leu Lys Leu 
    50                  55                  60                  


Ala Glu Lys Leu Lys Gly Gln Val Lys Phe Met Phe Gly Ala Pro Met 
65                  70                  75                  80  


Glu Pro Leu Ala Lys Leu Glu Leu Val Asp Val Val Gln Arg Leu Gly 
                85                  90                  95      


Leu Asn His Leu Phe Glu Thr Glu Ile Lys Glu Ala Leu Phe Ser Ile 
            100                 105                 110         


Tyr Lys Asp Gly Ser Asn Gly Trp Trp Phe Gly His Leu His Ala Thr 
        115                 120                 125             


Ser Leu Arg Phe Arg Leu Leu Arg Gln Cys Gly Leu Phe Ile Pro Gln 
    130                 135                 140                 


Asp Val Phe Lys Thr Phe Gln Asn Lys Thr Gly Glu Phe Asp Met Lys 
145                 150                 155                 160 


Leu Trp Asp Asn Val Lys Gly Leu Leu Ser Leu Tyr Glu Ala Ser Tyr 
                165                 170                 175     


Leu Gly Trp Lys Gly Glu Asn Ile Leu Asp Glu Ala Lys Ala Phe Thr 
            180                 185                 190         


Thr Lys Cys Leu Lys Ser Ala Trp Glu Asn Ile Ser Glu Lys Trp Leu 
        195                 200                 205             


Ala Lys Arg Val Lys His Ala Leu Ala Leu Pro Leu His Trp Arg Val 
    210                 215                 220                 


Pro Arg Ile Glu Ala Arg Trp Phe Ile Glu Val Tyr Glu Gln Glu Ala 
225                 230                 235                 240 


Asn Met Asn Pro Thr Leu Leu Lys Leu Ala Lys Leu Asp Phe Asn Met 
                245                 250                 255     


Val Gln Ser Ile His Gln Lys Glu Ile Gly Glu Leu Ala Arg Trp Trp 
            260                 265                 270         


Val Thr Thr Gly Leu Asp Lys Leu Asp Phe Ala Arg Asn Asn Leu Leu 
        275                 280                 285             


Gln Ser Tyr Met Trp Ser Cys Pro Ile Ala Ser Asp Pro Lys Phe Lys 
    290                 295                 300                 


Leu Ala Arg Glu Thr Ile Val Glu Ile Gly Ser Val Leu Thr Val Val 
305                 310                 315                 320 


Asp Asp Gly Tyr Asp Val Tyr Gly Ser Met Asp Glu Leu Asp Leu Tyr 
                325                 330                 335     


Thr Ser Ser Val Glu Arg Trp Ser Cys Val Lys Ile Asp Lys Leu Pro 
            340                 345                 350         


Asn Thr Leu Lys Leu Ile Phe Met Ser Met Phe Asn Lys Thr Asn Glu 
        355                 360                 365             


Val Gly Leu Arg Val Gln His Glu Arg Gly Tyr Asn Ser Ile Pro Thr 
    370                 375                 380                 


Phe Ile Lys Ala Trp Val Glu Gln Cys Lys Ser Tyr Gln Lys Glu Ala 
385                 390                 395                 400 


Arg Trp Phe His Gly Gly His Thr Pro Pro Leu Glu Glu Tyr Ser Leu 
                405                 410                 415     


Asn Gly Leu Val Ser Ile Gly Phe Pro Leu Leu Leu Ile Thr Gly Tyr 
            420                 425                 430         


Val Ala Ile Ala Glu Asn Glu Ala Ala Leu Asp Lys Val His Pro Leu 
        435                 440                 445             


Pro Asp Leu Leu His Tyr Ser Ser Leu Leu Ser Arg Leu Ile Asn Asp 
    450                 455                 460                 


Ile Gly Thr Ser Pro Asp Glu Met Ala Arg Gly Asp Asn Leu Lys Ser 
465                 470                 475                 480 


Ile His Cys Tyr Met Asn Glu Thr Gly Ala Ser Glu Glu Val Ala Arg 
                485                 490                 495     


Glu His Ile Lys Gly Val Ile Glu Glu Asn Trp Lys Ile Leu Asn Gln 
            500                 505                 510         


Cys Cys Phe Asp Gln Ser Gln Phe Gln Glu Pro Phe Ile Thr Phe Asn 
        515                 520                 525             


Leu Asn Ser Val Arg Gly Ser His Phe Phe Tyr Glu Phe Gly Asp Gly 
    530                 535                 540                 


Phe Gly Val Thr Asp Ser Trp Thr Lys Val Asp Met Lys Ser Val Leu 
545                 550                 555                 560 


Ile Asp Pro Ile Pro Leu Gly Glu Glu 
                565                 


