                           SEQUENCE LISTING

<110>  Compugen Ltd

<120>  POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG 
 TARGET FOR PRODUCING DRUGS AND BIOLOGICS

<130>  0000

<160>  201


<210>  1
<211>  916
<212>  DNA
<213>  Homo sapiens

<400> 1

gggacggagg cggggcccag gttggggcgg ggccgggccc aggtacagcg gccctgcggc     60

tggcgcggcg gacgggatga ggcgctgcag tctctgcgct ttcgacgccg cccgggggcc    120

caggcggctg atgcgtgtgg gcctcgcgct gatcttggtg ggccacgtga acctgctgct    180

gggggccgtg ctgcatggca ccgtcctgcg gcacgtggcc aatccccgcg gcgctgtcac    240

gccggagtac accgtagcca atgtcatctc tgtcggctcg gggctgctga gcgtttccgt    300

gggacttgtg gccctcctgg cgtccaggaa ccttcttcgc cctccactgc actgggtcct    360

gctggcacta gctctggtga acctgctctt gtccgttgcc tgctccctgg gcctccttct    420

tgctgtgtca ctcactgtgg ccaacggtgg ccgccgcctt attgctgact gccacccagg    480

actgctggat cctctggtac cactggatga ggggccggga catactgact gcccctttga    540

ccccacaaga atctatgata cagccttggc tctctggatc ccttctttgc tcatgtctgc    600

aggggaggct gctctatctg gttactgctg tgtggctgca ctcactctac gtggagttgg    660

gccctgcagg aaggacggac ttcaggggca gctagaggaa atgacagagc ttgaatctcc    720

taaatgtaaa aggcaggaaa atgagcagct actggatcaa aatcaagaaa tccgggcatc    780

acagagaagt tgggtttagg acagcaggtg ctgttccgag actcagtcct aaagggtttt    840

ttttcccact aagcaagggg ccctgacctc gggatgagat aacaaattgt aataaagtaa    900

cttctctttt cttcta                                                    916


<210>  2
<211>  78
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 2

gtgagcgcgg caggcgaccc gggcgggggc cgggctcccg gagagcccag caggccaaag     60

gctttgtgtc ttccacag                                                   78


<210>  3
<211>  994
<212>  DNA
<213>  Homo sapiens

<400> 3

gggacggagg cggggcccag gttggggcgg ggccgggccc aggtacagcg gccctgcggc     60

tggcgcggcg gacgggatga ggcgctgcag tctctgcgct ttcgacgccg cccgggggcc    120

caggcggctg atgcgtgtgg gcctcgcgct gatcttggtg ggccacgtga acctgctgct    180

gggggccgtg ctgcatggca ccgtcctgcg gcacgtggcc aatccccgcg gcgctgtcac    240

gccggagtac accgtagcca atgtcatctc tgtcggctcg gggctgctgg tgagcgcggc    300

aggcgacccg ggcgggggcc gggctcccgg agagcccagc aggccaaagg ctttgtgtct    360

tccacagagc gtttccgtgg gacttgtggc cctcctggcg tccaggaacc ttcttcgccc    420

tccactgcac tgggtcctgc tggcactagc tctggtgaac ctgctcttgt ccgttgcctg    480

ctccctgggc ctccttcttg ctgtgtcact cactgtggcc aacggtggcc gccgccttat    540

tgctgactgc cacccaggac tgctggatcc tctggtacca ctggatgagg ggccgggaca    600

tactgactgc ccctttgacc ccacaagaat ctatgataca gccttggctc tctggatccc    660

ttctttgctc atgtctgcag gggaggctgc tctatctggt tactgctgtg tggctgcact    720

cactctacgt ggagttgggc cctgcaggaa ggacggactt caggggcagc tagaggaaat    780

gacagagctt gaatctccta aatgtaaaag gcaggaaaat gagcagctac tggatcaaaa    840

tcaagaaatc cgggcatcac agagaagttg ggtttaggac agcaggtgct gttccgagac    900

tcagtcctaa agggtttttt ttcccactaa gcaaggggcc ctgacctcgg gatgagataa    960

caaattgtaa taaagtaact tctcttttct tcta                                994


<210>  4
<211>  1332
<212>  DNA
<213>  Homo sapiens

<400> 4

gggacggagg cggggcccag gttggggcgg ggccgggccc aggtacagcg gccctgcggc     60

tggcgcggcg gacgggatga ggcgctgcag tctctgcgct ttcgacgccg cccgggggcc    120

caggcggctg atgcgtgtgg gcctcgcgct gatcttggtg ggccacgtga acctgctgct    180

gggggccgtg ctgcatggca ccgtcctgcg gcacgtggcc aatccccgcg gcgctgtcac    240

gccggagtac accgtagcca atgtcatctc tgtcggctcg gggctgctga gcgtttccgt    300

gggacttgtg gccctcctgg cgtccaggaa ccttcttcgc cctccactgc actgggtcct    360

gctggcacta gctctggtga acctgctctt gtccgttgcc tgctccctgg gcctccttct    420

tgctgtgtca ctcactgtgg ccaacggtgg ccgccgcctt attgctgact gccacccagg    480

actgctggat cctctggtac cactggatga ggggccggga catactgact gcccctttga    540

ccccacaaga atctatgata cagccttggc tctctggatc ccttctttgc tcatgtctgc    600

aggggaggct gctctatctg gttactgctg tgtggctgca ctcactctac gtggagttgg    660

gccctgcagg aaggacggac ttcaggggca ggtaaggaag gcaaacagga agggttcatt    720

ccacagagac tggctgtgtt gaaaagatgc tgaccggccg ggtgcggagg ctcacacctg    780

taatcccagc actttgggag gctgaggcag gcggatcact tgaggtcagg agtttgagac    840

cagcttggac aacatggtga aacctcgtct ctactaaaaa tacaaaaaat taggtggggt    900

ggtgggcgcc tgtaatccca gctacttgga aggctgaggc aggagaatcg cttgaacccg    960

gaaggcggag gttgcagtga accgagatca cgccactgca ctccagcctg ggcaacagag   1020

tgaggctccg tcacaaaaaa caaaacaaaa aaaagatgct gacctatcat tcagggcgag   1080

ggtgtctaac tctatcttct tctgcagcta gaggaaatga cagagcttga atctcctaaa   1140

tgtaaaaggc aggaaaatga gcagctactg gatcaaaatc aagaaatccg ggcatcacag   1200

agaagttggg tttaggacag caggtgctgt tccgagactc agtcctaaag ggtttttttt   1260

cccactaagc aaggggccct gacctcggga tgagataaca aattgtaata aagtaacttc   1320

tcttttcttc ta                                                       1332


<210>  5
<211>  871
<212>  DNA
<213>  Homo sapiens

<400> 5

gggacggagg cggggcccag gttggggcgg ggccgggccc aggtacagcg gccctgcggc     60

tggcgcggcg gacgggatga ggcgctgcag tctctgcgct ttcgacgccg cccgggggcc    120

caggcggctg atgcgtgtgg gcctcgcgct gatcttggtg ggccacgtga acctgctgct    180

gggggccgtg ctgcatggca ccgtcctgcg gcacgtggcc aatccccgcg gcgctgtcac    240

gccggagtac accgtagcca atgtcatctc tgtcggctcg gggctgctga gcgtttccgt    300

gggacttgtg gccctcctgg cgtccaggaa ccttcttcgc cctccactgc actgggtcct    360

gctggcacta gctctggtga acctgctctt gtccgttgcc tgctccctgg gcctccttct    420

tgctgtgtca ctcactgtgg ccaacggtgg ccgccgcctt attgctgact gccacccagg    480

actgctggat cctctggtac cactggatga ggggccggga catactgact gcccctttga    540

ccccacaaga atctatgata cagccttggc tctctggatc ccttctttgc tcatgtctgc    600

aggggaggct gctctatctg gttactgctg tgtggctgca ctcactctac gtggagttgg    660

gccctgcagg aaggacggac ttcaggggca ggtagtagct gggtgtgacg caagagtgaa    720

acagaaagcc tggcagccac ggtttcctgg gattaaagtc aaagcattat gaatatggca    780

ctaaagtgac tgagctacca gaccaatgat cctgtaaggc agccacagaa ctaaaaaaca    840

acaattatta ttaaactgct ctggattctc a                                   871


<210>  6
<211>  709
<212>  DNA
<213>  Homo sapiens

<400> 6

gggacggagg cggggcccag gttggggcgg ggccgggccc aggtacagcg gccctgcggc     60

tggcgcggcg gacgggatga ggcgctgcag tctctgcgct ttcgacgccg cccgggggcc    120

caggcggctg atgcgtgtgg gcctcgcgct gatcttggtg ggccacgtga acctgctgct    180

gggggccgtg ctgcatggca ccgtcctgcg gcacgtggcc aatccccgcg gcgctgtcac    240

gccggagtac accgtagcca atgtcatctc tgtcggctcg gggctgctga gcgtttccgt    300

gggacttgtg gccctcctgg cgtccaggaa ccttcttcgc cctccactgg atacagcctt    360

ggctctctgg atcccttctt tgctcatgtc tgcaggggag gctgctctat ctggttactg    420

ctgtgtggct gcactcactc tacgtggagt tgggccctgc aggaaggacg gacttcaggg    480

gcagctagag gaaatgacag agcttgaatc tcctaaatgt aaaaggcagg aaaatgagca    540

gctactggat caaaatcaag aaatccgggc atcacagaga agttgggttt aggacagcag    600

gtgctgttcc gagactcagt cctaaagggt tttttttccc actaagcaag gggccctgac    660

ctcgggatga gataacaaat tgtaataaag taacttctct tttcttcta                709


<210>  7
<211>  240
<212>  PRT
<213>  Homo sapiens

<400> 7

Met Arg Arg Cys Ser Leu Cys Ala Phe Asp Ala Ala Arg Gly Pro Arg 
1               5                   10                  15      

Arg Leu Met Arg Val Gly Leu Ala Leu Ile Leu Val Gly His Val Asn 
            20                  25                  30          

Leu Leu Leu Gly Ala Val Leu His Gly Thr Val Leu Arg His Val Ala 
        35                  40                  45              

Asn Pro Arg Gly Ala Val Thr Pro Glu Tyr Thr Val Ala Asn Val Ile 
    50                  55                  60                  

Ser Val Gly Ser Gly Leu Leu Ser Val Ser Val Gly Leu Val Ala Leu 
65                  70                  75                  80  

Leu Ala Ser Arg Asn Leu Leu Arg Pro Pro Leu His Trp Val Leu Leu 
                85                  90                  95      

Ala Leu Ala Leu Val Asn Leu Leu Leu Ser Val Ala Cys Ser Leu Gly 
            100                 105                 110         

Leu Leu Leu Ala Val Ser Leu Thr Val Ala Asn Gly Gly Arg Arg Leu 
        115                 120                 125             

Ile Ala Asp Cys His Pro Gly Leu Leu Asp Pro Leu Val Pro Leu Asp 
    130                 135                 140                 

Glu Gly Pro Gly His Thr Asp Cys Pro Phe Asp Pro Thr Arg Ile Tyr 
145                 150                 155                 160 

Asp Thr Ala Leu Ala Leu Trp Ile Pro Ser Leu Leu Met Ser Ala Gly 
                165                 170                 175     

Glu Ala Ala Leu Ser Gly Tyr Cys Cys Val Ala Ala Leu Thr Leu Arg 
            180                 185                 190         

Gly Val Gly Pro Cys Arg Lys Asp Gly Leu Gln Gly Gln Leu Glu Glu 
        195                 200                 205             

Met Thr Glu Leu Glu Ser Pro Lys Cys Lys Arg Gln Glu Asn Glu Gln 
    210                 215                 220                 

Leu Leu Asp Gln Asn Gln Glu Ile Arg Ala Ser Gln Arg Ser Trp Val 
225                 230                 235                 240 


<210>  8
<211>  240
<212>  PRT
<213>  Homo sapiens

<400> 8

Met Arg Arg Cys Ser Leu Cys Ala Phe Asp Ala Ala Arg Gly Pro Arg 
1               5                   10                  15      

Arg Leu Met Arg Val Gly Leu Ala Leu Ile Leu Val Gly His Val Asn 
            20                  25                  30          

Leu Leu Leu Gly Ala Val Leu His Gly Thr Val Leu Arg His Val Ala 
        35                  40                  45              

Asn Pro Arg Gly Ala Val Thr Pro Glu Tyr Thr Val Ala Asn Val Ile 
    50                  55                  60                  

Ser Val Gly Ser Gly Leu Leu Ser Val Ser Val Gly Leu Val Thr Leu 
65                  70                  75                  80  

Leu Ala Ser Arg Asn Leu Leu Arg Pro Pro Leu His Trp Val Leu Leu 
                85                  90                  95      

Ala Leu Ala Leu Val Asn Leu Leu Leu Ser Val Ala Cys Ser Leu Gly 
            100                 105                 110         

Leu Leu Leu Ala Val Ser Leu Thr Val Ala Asn Gly Gly Arg Arg Leu 
        115                 120                 125             

Ile Ala Asp Cys His Pro Gly Leu Leu Asp Pro Leu Val Pro Leu Asp 
    130                 135                 140                 

Glu Gly Pro Gly His Thr Asp Cys Pro Phe Asp Pro Thr Arg Ile Tyr 
145                 150                 155                 160 

Asp Thr Ala Leu Ala Leu Trp Ile Pro Ser Leu Leu Met Ser Ala Gly 
                165                 170                 175     

Glu Ala Ala Leu Ser Gly Tyr Cys Cys Val Ala Ala Leu Thr Leu Arg 
            180                 185                 190         

Gly Val Gly Pro Cys Arg Lys Asp Gly Leu Gln Gly Gln Leu Glu Glu 
        195                 200                 205             

Met Thr Glu Leu Glu Ser Pro Lys Cys Lys Arg Gln Glu Asn Glu Gln 
    210                 215                 220                 

Leu Leu Asp Gln Asn Gln Glu Ile Arg Ala Ser Gln Arg Ser Trp Val 
225                 230                 235                 240 


<210>  9
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 9

gtaaggaagg caaacaggaa gggttcattc cacagagact ggctgtgt                  48


<210>  10
<211>  266
<212>  PRT
<213>  Homo sapiens

<400> 10

Met Arg Arg Cys Ser Leu Cys Ala Phe Asp Ala Ala Arg Gly Pro Arg 
1               5                   10                  15      

Arg Leu Met Arg Val Gly Leu Ala Leu Ile Leu Val Gly His Val Asn 
            20                  25                  30          

Leu Leu Leu Gly Ala Val Leu His Gly Thr Val Leu Arg His Val Ala 
        35                  40                  45              

Asn Pro Arg Gly Ala Val Thr Pro Glu Tyr Thr Val Ala Asn Val Ile 
    50                  55                  60                  

Ser Val Gly Ser Gly Leu Leu Val Ser Ala Ala Gly Asp Pro Gly Gly 
65                  70                  75                  80  

Gly Arg Ala Pro Gly Glu Pro Ser Arg Pro Lys Ala Leu Cys Leu Pro 
                85                  90                  95      

Gln Ser Val Ser Val Gly Leu Val Ala Leu Leu Ala Ser Arg Asn Leu 
            100                 105                 110         

Leu Arg Pro Pro Leu His Trp Val Leu Leu Ala Leu Ala Leu Val Asn 
        115                 120                 125             

Leu Leu Leu Ser Val Ala Cys Ser Leu Gly Leu Leu Leu Ala Val Ser 
    130                 135                 140                 

Leu Thr Val Ala Asn Gly Gly Arg Arg Leu Ile Ala Asp Cys His Pro 
145                 150                 155                 160 

Gly Leu Leu Asp Pro Leu Val Pro Leu Asp Glu Gly Pro Gly His Thr 
                165                 170                 175     

Asp Cys Pro Phe Asp Pro Thr Arg Ile Tyr Asp Thr Ala Leu Ala Leu 
            180                 185                 190         

Trp Ile Pro Ser Leu Leu Met Ser Ala Gly Glu Ala Ala Leu Ser Gly 
        195                 200                 205             

Tyr Cys Cys Val Ala Ala Leu Thr Leu Arg Gly Val Gly Pro Cys Arg 
    210                 215                 220                 

Lys Asp Gly Leu Gln Gly Gln Leu Glu Glu Met Thr Glu Leu Glu Ser 
225                 230                 235                 240 

Pro Lys Cys Lys Arg Gln Glu Asn Glu Gln Leu Leu Asp Gln Asn Gln 
                245                 250                 255     

Glu Ile Arg Ala Ser Gln Arg Ser Trp Val 
            260                 265     


<210>  11
<211>  221
<212>  PRT
<213>  Homo sapiens

<400> 11

Met Arg Arg Cys Ser Leu Cys Ala Phe Asp Ala Ala Arg Gly Pro Arg 
1               5                   10                  15      

Arg Leu Met Arg Val Gly Leu Ala Leu Ile Leu Val Gly His Val Asn 
            20                  25                  30          

Leu Leu Leu Gly Ala Val Leu His Gly Thr Val Leu Arg His Val Ala 
        35                  40                  45              

Asn Pro Arg Gly Ala Val Thr Pro Glu Tyr Thr Val Ala Asn Val Ile 
    50                  55                  60                  

Ser Val Gly Ser Gly Leu Leu Ser Val Ser Val Gly Leu Val Ala Leu 
65                  70                  75                  80  

Leu Ala Ser Arg Asn Leu Leu Arg Pro Pro Leu His Trp Val Leu Leu 
                85                  90                  95      

Ala Leu Ala Leu Val Asn Leu Leu Leu Ser Val Ala Cys Ser Leu Gly 
            100                 105                 110         

Leu Leu Leu Ala Val Ser Leu Thr Val Ala Asn Gly Gly Arg Arg Leu 
        115                 120                 125             

Ile Ala Asp Cys His Pro Gly Leu Leu Asp Pro Leu Val Pro Leu Asp 
    130                 135                 140                 

Glu Gly Pro Gly His Thr Asp Cys Pro Phe Asp Pro Thr Arg Ile Tyr 
145                 150                 155                 160 

Asp Thr Ala Leu Ala Leu Trp Ile Pro Ser Leu Leu Met Ser Ala Gly 
                165                 170                 175     

Glu Ala Ala Leu Ser Gly Tyr Cys Cys Val Ala Ala Leu Thr Leu Arg 
            180                 185                 190         

Gly Val Gly Pro Cys Arg Lys Asp Gly Leu Gln Gly Gln Val Arg Lys 
        195                 200                 205             

Ala Asn Arg Lys Gly Ser Phe His Arg Asp Trp Leu Cys 
    210                 215                 220     


<210>  12
<211>  231
<212>  PRT
<213>  Homo sapiens

<400> 12

Met Arg Arg Cys Ser Leu Cys Ala Phe Asp Ala Ala Arg Gly Pro Arg 
1               5                   10                  15      

Arg Leu Met Arg Val Gly Leu Ala Leu Ile Leu Val Gly His Val Asn 
            20                  25                  30          

Leu Leu Leu Gly Ala Val Leu His Gly Thr Val Leu Arg His Val Ala 
        35                  40                  45              

Asn Pro Arg Gly Ala Val Thr Pro Glu Tyr Thr Val Ala Asn Val Ile 
    50                  55                  60                  

Ser Val Gly Ser Gly Leu Leu Ser Val Ser Val Gly Leu Val Ala Leu 
65                  70                  75                  80  

Leu Ala Ser Arg Asn Leu Leu Arg Pro Pro Leu His Trp Val Leu Leu 
                85                  90                  95      

Ala Leu Ala Leu Val Asn Leu Leu Leu Ser Val Ala Cys Ser Leu Gly 
            100                 105                 110         

Leu Leu Leu Ala Val Ser Leu Thr Val Ala Asn Gly Gly Arg Arg Leu 
        115                 120                 125             

Ile Ala Asp Cys His Pro Gly Leu Leu Asp Pro Leu Val Pro Leu Asp 
    130                 135                 140                 

Glu Gly Pro Gly His Thr Asp Cys Pro Phe Asp Pro Thr Arg Ile Tyr 
145                 150                 155                 160 

Asp Thr Ala Leu Ala Leu Trp Ile Pro Ser Leu Leu Met Ser Ala Gly 
                165                 170                 175     

Glu Ala Ala Leu Ser Gly Tyr Cys Cys Val Ala Ala Leu Thr Leu Arg 
            180                 185                 190         

Gly Val Gly Pro Cys Arg Lys Asp Gly Leu Gln Gly Gln Val Val Ala 
        195                 200                 205             

Gly Cys Asp Ala Arg Val Lys Gln Lys Ala Trp Gln Pro Arg Phe Pro 
    210                 215                 220                 

Gly Ile Lys Val Lys Ala Leu 
225                 230     


<210>  13
<211>  171
<212>  PRT
<213>  Homo sapiens

<400> 13

Met Arg Arg Cys Ser Leu Cys Ala Phe Asp Ala Ala Arg Gly Pro Arg 
1               5                   10                  15      

Arg Leu Met Arg Val Gly Leu Ala Leu Ile Leu Val Gly His Val Asn 
            20                  25                  30          

Leu Leu Leu Gly Ala Val Leu His Gly Thr Val Leu Arg His Val Ala 
        35                  40                  45              

Asn Pro Arg Gly Ala Val Thr Pro Glu Tyr Thr Val Ala Asn Val Ile 
    50                  55                  60                  

Ser Val Gly Ser Gly Leu Leu Ser Val Ser Val Gly Leu Val Ala Leu 
65                  70                  75                  80  

Leu Ala Ser Arg Asn Leu Leu Arg Pro Pro Leu Asp Thr Ala Leu Ala 
                85                  90                  95      

Leu Trp Ile Pro Ser Leu Leu Met Ser Ala Gly Glu Ala Ala Leu Ser 
            100                 105                 110         

Gly Tyr Cys Cys Val Ala Ala Leu Thr Leu Arg Gly Val Gly Pro Cys 
        115                 120                 125             

Arg Lys Asp Gly Leu Gln Gly Gln Leu Glu Glu Met Thr Glu Leu Glu 
    130                 135                 140                 

Ser Pro Lys Cys Lys Arg Gln Glu Asn Glu Gln Leu Leu Asp Gln Asn 
145                 150                 155                 160 

Gln Glu Ile Arg Ala Ser Gln Arg Ser Trp Val 
                165                 170     


<210>  14
<211>  1252
<212>  DNA
<213>  Homo sapiens

<400> 14

gaaggagatc aggcagagga gagaagagtc agtgtgaact aggctggtgg ctctgtccgg     60

tagggagacg gaaagggtgc cgcccatcat agaagtacca gaacttgagc tggactttgc    120

tgatttagct tatggaagag gaaccagaaa tttgtccttg aataatgttt cccgacaacg    180

aagaggcaga aggatctggg cctgtgcgcg acgccccggg ggacgaggct catggagaag    240

tttcgggcgg tgctggacct gcacgtcaag caccacagcg ccttgggcta cggcctggtg    300

accctgctga cggcgggcgg ggagcgcatc ttctccgccg tggcattcca gtgcccgtgc    360

agcgccgcct ggaacctgcc ctacggcctg gtcttcttgc tggtgccggc gctcgcgctc    420

ttcctcctgg gctacgtgct gagcgcacgc acgtggcgcc tgctcaccgg atgctgctcc    480

agcgcccgcg cgagttgcgg atcggcgctg cgcggctccc tggtgtgcgc gcaaatcagc    540

gcggccgccg cgctcgcgcc cctcacctgg gtggccgtgg cgctgctcgg gggcgccttt    600

tacgagtgcg cggccaccgg gagcgcggcc ttcgcgcagc gcctgtgcct cggccgcaac    660

cgcagctgcg ccgcggagct gccgctggtg ccgtgcaacc aggccaaggc gtcggacgtg    720

caggacctcc tgaaggatct gaaggctcag tcgcaggtgt tgggctggat cttgatagca    780

gttgttatca tcattcttct gatttttaca tctgtcaccc gatgcctatc tccagttagt    840

tttctgcagc tgaaattctg gaaaatctat ttggaacagg agcagcagat ccttaaaagt    900

aaagccacag agcatgcaac tgaattggca aaagagaata ttaaatgttt ctttgagggc    960

tcgcatccaa aagaatataa cactccaagc atgaaagagt ggcagcaaat ttcatcactg   1020

tatactttca atccgaaggg ccagtactac agcatgttgc acaaatatgt caacagaaaa   1080

gagaagactc acagtatcag gtctactgaa ggagatacgg tgattcctgt tcttggcttt   1140

gtagattcat ctggtataaa cagcactcct gagttatgac cttttgaatg agtagaaaaa   1200

aaaattgttt tgaattattg ctttattaaa aaataaacat tggtattttt tg           1252


<210>  15
<211>  315
<212>  PRT
<213>  Homo sapiens

<400> 15

Met Glu Lys Phe Arg Ala Val Leu Asp Leu His Val Lys His His Ser 
1               5                   10                  15      

Ala Leu Gly Tyr Gly Leu Val Thr Leu Leu Thr Ala Gly Gly Glu Arg 
            20                  25                  30          

Ile Phe Ser Ala Val Ala Phe Gln Cys Pro Cys Ser Ala Ala Trp Asn 
        35                  40                  45              

Leu Pro Tyr Gly Leu Val Phe Leu Leu Val Pro Ala Leu Ala Leu Phe 
    50                  55                  60                  

Leu Leu Gly Tyr Val Leu Ser Ala Arg Thr Trp Arg Leu Leu Thr Gly 
65                  70                  75                  80  

Cys Cys Ser Ser Ala Arg Ala Ser Cys Gly Ser Ala Leu Arg Gly Ser 
                85                  90                  95      

Leu Val Cys Thr Gln Ile Ser Ala Ala Ala Ala Leu Ala Pro Leu Thr 
            100                 105                 110         

Trp Val Ala Val Ala Leu Leu Gly Gly Ala Phe Tyr Glu Cys Ala Ala 
        115                 120                 125             

Thr Gly Ser Ala Ala Phe Ala Gln Arg Leu Cys Leu Gly Arg Asn Arg 
    130                 135                 140                 

Ser Cys Ala Ala Glu Leu Pro Leu Val Pro Cys Asn Gln Ala Lys Ala 
145                 150                 155                 160 

Ser Asp Val Gln Asp Leu Leu Lys Asp Leu Lys Ala Gln Ser Gln Val 
                165                 170                 175     

Leu Gly Trp Ile Leu Ile Ala Val Val Ile Ile Ile Leu Leu Ile Phe 
            180                 185                 190         

Thr Ser Val Thr Arg Cys Leu Ser Pro Val Ser Phe Leu Gln Leu Lys 
        195                 200                 205             

Phe Trp Lys Ile Tyr Leu Glu Gln Glu Gln Gln Ile Leu Lys Ser Lys 
    210                 215                 220                 

Ala Thr Glu His Ala Thr Glu Leu Ala Lys Glu Asn Ile Lys Cys Phe 
225                 230                 235                 240 

Phe Glu Gly Ser His Pro Lys Glu Tyr Asn Thr Pro Ser Met Lys Glu 
                245                 250                 255     

Trp Gln Gln Ile Ser Ser Leu Tyr Thr Phe Asn Pro Lys Gly Gln Tyr 
            260                 265                 270         

Tyr Ser Met Leu His Lys Tyr Val Asn Arg Lys Glu Lys Thr His Ser 
        275                 280                 285             

Ile Arg Ser Thr Glu Gly Asp Thr Val Ile Pro Val Leu Gly Phe Val 
    290                 295                 300                 

Asp Ser Ser Gly Ile Asn Ser Thr Pro Glu Leu 
305                 310                 315 


<210>  16
<211>  143
<212>  PRT
<213>  Homo sapiens

<400> 16

Met Phe Pro Val Leu Gly Trp Ile Leu Ile Ala Val Val Ile Ile Ile 
1               5                   10                  15      

Leu Leu Ile Phe Thr Ser Val Thr Arg Cys Leu Ser Pro Val Ser Phe 
            20                  25                  30          

Leu Gln Leu Lys Phe Trp Lys Ile Tyr Leu Glu Gln Glu Gln Gln Ile 
        35                  40                  45              

Leu Lys Ser Lys Ala Thr Glu His Ala Thr Glu Leu Ala Lys Glu Asn 
    50                  55                  60                  

Ile Lys Cys Phe Phe Glu Gly Ser His Pro Lys Glu Tyr Asn Thr Pro 
65                  70                  75                  80  

Ser Met Lys Glu Trp Gln Gln Ile Ser Ser Leu Tyr Thr Phe Asn Pro 
                85                  90                  95      

Lys Gly Gln Tyr Tyr Ser Met Leu His Lys Tyr Val Asn Arg Lys Glu 
            100                 105                 110         

Lys Thr His Ser Ile Arg Ser Thr Glu Gly Asp Thr Val Ile Pro Val 
        115                 120                 125             

Leu Gly Phe Val Asp Ser Ser Gly Ile Asn Ser Thr Pro Glu Leu 
    130                 135                 140             


<210>  17
<211>  158
<212>  PRT
<213>  Homo sapiens

<400> 17

Arg Trp Gly Arg Leu Gly Gly Ala Glu Arg Pro Ser Phe Leu Arg Ala 
1               5                   10                  15      

Ala Gly Val Leu Gly Trp Ile Leu Ile Ala Val Val Ile Ile Ile Leu 
            20                  25                  30          

Leu Ile Phe Thr Ser Val Thr Arg Cys Leu Ser Pro Val Ser Phe Leu 
        35                  40                  45              

Gln Leu Lys Phe Trp Lys Ile Tyr Leu Glu Gln Glu Gln Gln Ile Leu 
    50                  55                  60                  

Lys Ser Lys Ala Thr Glu His Ala Thr Glu Leu Ala Lys Glu Asn Ile 
65                  70                  75                  80  

Lys Cys Phe Phe Glu Gly Ser His Pro Lys Glu Tyr Asn Thr Pro Ser 
                85                  90                  95      

Met Lys Glu Trp Gln Gln Ile Ser Ser Leu Tyr Thr Phe Asn Pro Lys 
            100                 105                 110         

Gly Gln Tyr Tyr Ser Met Leu His Lys Tyr Val Asn Arg Lys Glu Lys 
        115                 120                 125             

Thr His Ser Ile Arg Ser Thr Glu Gly Asp Thr Val Ile Pro Val Leu 
    130                 135                 140                 

Gly Phe Val Asp Ser Ser Gly Ile Asn Ser Thr Pro Glu Leu 
145                 150                 155             


<210>  18
<211>  315
<212>  PRT
<213>  Homo sapiens

<400> 18

Met Glu Lys Phe Arg Ala Val Leu Asp Leu His Val Lys His His Ser 
1               5                   10                  15      

Ala Leu Gly Tyr Gly Leu Val Thr Leu Leu Thr Ala Gly Gly Glu Arg 
            20                  25                  30          

Ile Phe Ser Ala Val Ala Phe Gln Cys Pro Cys Ser Ala Ala Trp Asn 
        35                  40                  45              

Leu Pro Tyr Gly Leu Val Phe Leu Leu Val Pro Ala Leu Ala Leu Phe 
    50                  55                  60                  

Leu Leu Gly Tyr Val Leu Ser Ala Arg Thr Trp Arg Leu Leu Thr Gly 
65                  70                  75                  80  

Cys Cys Ser Ser Ala Arg Ala Ser Cys Gly Ser Ala Leu Arg Gly Ser 
                85                  90                  95      

Leu Val Cys Ala Gln Ile Ser Ala Ala Ala Ala Leu Ala Pro Leu Thr 
            100                 105                 110         

Trp Val Ala Val Ala Leu Leu Gly Gly Ala Phe Tyr Glu Cys Ala Ala 
        115                 120                 125             

Thr Gly Ser Ala Ala Phe Ala Gln Arg Leu Cys Leu Gly Arg Asn Arg 
    130                 135                 140                 

Ser Cys Ala Ala Glu Leu Pro Leu Val Pro Cys Asn Gln Ala Lys Ala 
145                 150                 155                 160 

Ser Asp Val Gln Asp Leu Leu Lys Asp Leu Lys Ala Gln Ser Gln Val 
                165                 170                 175     

Leu Gly Trp Ile Leu Ile Ala Val Val Ile Ile Ile Leu Leu Ile Phe 
            180                 185                 190         

Thr Ser Val Thr Arg Cys Leu Ser Pro Val Ser Phe Leu Gln Leu Lys 
        195                 200                 205             

Phe Trp Lys Ile Tyr Leu Glu Gln Glu Gln Gln Ile Leu Lys Ser Lys 
    210                 215                 220                 

Ala Thr Glu His Ala Thr Glu Leu Ala Lys Glu Asn Ile Lys Cys Phe 
225                 230                 235                 240 

Phe Glu Gly Ser His Pro Lys Glu Tyr Asn Thr Pro Ser Met Lys Glu 
                245                 250                 255     

Trp Gln Gln Ile Ser Ser Leu Tyr Thr Phe Asn Pro Lys Gly Gln Tyr 
            260                 265                 270         

Tyr Ser Met Leu His Lys Tyr Val Asn Arg Lys Glu Lys Thr His Ser 
        275                 280                 285             

Ile Arg Ser Thr Glu Gly Asp Thr Val Ile Pro Val Leu Gly Phe Val 
    290                 295                 300                 

Asp Ser Ser Gly Ile Asn Ser Thr Pro Glu Leu 
305                 310                 315 


<210>  19
<211>  194
<212>  PRT
<213>  Homo sapiens

<400> 19

Met Ala Ser Leu Trp Pro Ser Ala Leu Thr Phe Asn Thr Asp Ala Asn 
1               5                   10                  15      

Ile Pro Gly Pro Leu Gly Phe Cys Gly Gly Trp Val Arg Leu Cys Ser 
            20                  25                  30          

Leu Ser Ser Leu Thr Pro Pro Cys Gly Arg Arg Leu Val Pro Cys Leu 
        35                  40                  45              

Ser Ala Pro Ala Pro Asn Ala Pro Arg Leu Pro Ala Pro Ala Arg Cys 
    50                  55                  60                  

Ser Ile Gly Ala Leu Ile Gly Leu Ser Val Ala Ala Val Val Leu Leu 
65                  70                  75                  80  

Ala Phe Ile Val Thr Ala Cys Val Leu Cys Tyr Leu Phe Ile Ser Ser 
                85                  90                  95      

Lys Pro His Thr Lys Leu Asp Leu Gly Leu Ser Leu Gln Thr Ala Gly 
            100                 105                 110         

Pro Glu Glu Val Ser Pro Asp Cys Gln Gly Val Asn Thr Gly Met Ala 
        115                 120                 125             

Ala Glu Val Pro Lys Val Ser Pro Leu Gln Gln Ser Tyr Ser Cys Leu 
    130                 135                 140                 

Asn Pro Gln Leu Glu Ser Asn Glu Gly Gln Ala Val Asn Ser Lys Arg 
145                 150                 155                 160 

Leu Leu His His Cys Phe Met Ala Thr Val Thr Thr Ser Asp Ile Pro 
                165                 170                 175     

Gly Ser Pro Glu Glu Ala Ser Val Pro Asn Pro Asp Leu Cys Gly Pro 
            180                 185                 190         

Val Pro 
<210>  20

<211>  614
<212>  DNA
<213>  Homo sapiens

<400> 20

atggcttctc tctggccctc agctctcacc tttaacacgg atgcgaacat ccccgggccc     60

ctgggttttt gcggaggttg ggtgaggttg tgttcactct cctcactgac cccgccgtgt    120

ggtcgccggc tggtgccttg tctgtctgcc ccagccccga atgccccgag actcccggcg    180

ccggctcggt gcagcattgg cgctctcata ggcctgtccg tagcagcagt ggttcttctc    240

gccttcattg ttaccgcctg tgtgctctgc tacctgttca tcagctctaa gccccacaca    300

aagttggacc tgggcttgag cttacagaca gcaggccctg aggaggtttc tcctgactgc    360

caaggtgtga acacaggcat ggcggcagaa gtgccaaaag tgagccctct ccagcagagt    420

tactcctgct tgaacccgca gctggagagc aatgaggggc aggctgtgaa ctccaaacgc    480

ctcctccatc attgcttcat ggccacagtg accaccagtg acattccagg cagccctgag    540

gaagcctctg tacccaaccc tgacctatgt ggaccagtcc cataaacatt caataaatgt    600

ctccatacca tccc                                                      614


<210>  21
<211>  3517
<212>  DNA
<213>  Homo sapiens

<400> 21

acgcggctgc acggaccgcc aatgctgctg cctcccagag cagagggagg cagaagagga     60

gggagggaga agagtggaag ggagggggag gcggcacttg ggctgcagct cgcaaccaga    120

ggcagtgtct ctcagctctc ggaaggaccg agagaggcaa ccgcggagta ggatgctctg    180

cggggcgccc agagccgggg gcgcttgaag cagcttcggg gactggggca accgggcagt    240

tttcaccatg catcagtccc tgactcagca gcggtccagc gacatgtccc tgcccgattc    300

catgggagca ttcaatcgga ggaaacgaaa ctccatctat gtcaccgtga ctttgcttat    360

tgtgtccgtg ttaattctca cagtgggcct tgctgcaacc accaggaccc agaatgtgac    420

tgtaggaggt tattaccccg gagttattct cggctttgga tcgttccttg gaatcattgg    480

atcaaacctt attgagaaca aaaggcagat gctggtggct tctatcgtgt ttatcagctt    540

tggtgtgatt gcggcttttt gttgtgccat agttgacggg gtctttgctg ccagacacat    600

tgatctgaaa ccactctacg ctaaccggtg ccattatgtt cccaagacat cacagaagga    660

agctgaggag gtcataagtt cctcaaccaa aaattctcct tccacgaggg ttatgaggaa    720

ccttacccag gcagctagag aggttaactg ccctcacctc agccgtgaat tctgcacacc    780

tcgcatccgg ggcaacacct gcttctgctg tgacctctac aactgtggca accgggtgga    840

gatcactggt gggtactacg aatacatcga tgtcagcagt tgccaagata tcatccacct    900

ctaccacctg ctctggtctg ccaccatcct caacattgtt ggcctgttcc tgggcatcat    960

cactgccgct gtccttggag gctttaagga catgaaccca actctcccag cactgaactg   1020

ttctgttgaa aatacccatc caacagtttc ttactatgct catccccaag tggcatccta   1080

caatacctac taccatagcc ctcctcacct gccaccatat tctgcttatg actttcagca   1140

ttccggtgtc tttccatcct cccctccctc tggactttct gatgagcccc agtctgcctc   1200

tccctcaccc agctacatgt ggtcctcaag tgcaccgccc cgttactctc caccctacta   1260

tccacctttt gaaaagccac caccttacag tccctaaaga ggaatgcctg ctggctattg   1320

agattattgt ggcttttgta tttctgcttc agtggaagtg tgtagggtac aaaatttaaa   1380

gtgtgactct tatgcataaa gttttacaat ggcctgccag gctagggaaa gatagggacg   1440

aagcttattc attattagtg cagagcaggg gtggtcaggc tgaacgcagc acagaagggc   1500

agctcacatt ctctaagcaa gactggggag ccagcccagc aagaagcttg tttggacttg   1560

cattacccta tgctccacct ctgtattcag cagaagtgtg gttgccatct ttttcacttt   1620

atgtaaagga gtgttgccct cgggcccttg gcagattgcc accccagcac ctaggttgaa   1680

gcacctggtt tataggccct atctttccct acccctaaag tcagtcccta aggacaattt   1740

cccagctgat ggggctacac agtagttcca atacagagag ttctggctaa gattttgttt   1800

gcttgtgtct ggatgttgaa aaagactgcc cgtatctctt actccttcct tctctgtgag   1860

tattgtaaaa atggctgttg tgatcactca gctcagcttt tgttattggt acctcctaaa   1920

gggaaaagtg caatattctt gcatcttcag tagtggggaa caggatgtat tgttccggaa   1980

acactgaaat acacagcaac atgtgagatg ttttaagtag atcacttagg agacagtggt   2040

tctactacat gttgcattat tacaaaatac atttgctaca ggagatataa atcttatggt   2100

tgtaattcag agtttaaaaa tgttataaat taggttcttg ggtcgtgata tgaattgtta   2160

ctaatctttg tgactattta atcttcaaat attgtgctta accccagcaa tccgcacgta   2220

tcctgcaccc caccccaaaa gagtcatctg tattttaatg ccactggtct tatcggtcct   2280

tttgtctgtt gagaccagtc atgacagcat tcaagattat gaaagtgtta caatgccgct   2340

tcaagtctgc aaaacctcaa acgtagccaa cttgacaaat atttaagtgt tacggcagat   2400

ttaaaatcca tctggcacac cgtggtaggt atttgtacag ttcttttaat tacacatagc   2460

tttaaaccat caacctgatg agtttaaagc ttttgcaccc atgccttcac ttcagaatga   2520

acaccttcat tgtgatctta tgttaacctg agaattgatt taaaggaaga ttgataatcc   2580

tatactttat aacgtaaaaa tacaggggct acaggagggt acctaattag acagttctcc   2640

aaacacagaa cacacactgg aaaattttcc ggccaatttt gctacctccc aacttgatgg   2700

attagaggta gcgcaaatgc tggtgctccc atctaccttg tagacactta gccatcaaga   2760

atcaaggcac aagaagtgca ctctctcatt aacagtaaat gtttgcaaga tattcagttt   2820

aactttcagc atcatgaatg ttcttatcca gattttgaat ccgaaaaact ataatccttt   2880

tatgttatac aaaattacta tgatttttta cagttctgag catattaaaa ttctactgga   2940

tttcaaaaag agactaatac ccaactgact aactaaacaa atatcaactt gtaatactca   3000

atgaattttt ttgccattta catttgaccg ttggctttag tgaatgtcca tatttaattt   3060

tttaaggcac cattacacag tttatcctac atttatcaca tttcttaaag tgttaagatt   3120

ctatggctca tttctatgta tttttcttac tttacaaaat aacctgaaac agtatagatt   3180

ttgtaacact taatttgagc agctttttta ttacattgaa ttatataaag tgcatgttac   3240

cttagaaaaa ttaatatttg ctgctttact cttttgcaaa acatttgctg taatgaatgg   3300

atttgtattt ccaatatgta tcttgactgc attttgtaat atttactgct ttattcctaa   3360

ttctgcttta aagtactgaa ctgggcatga aacattaaaa tattaatcca gaaactgtat   3420

aaactggatg ttgcttaaaa tctgtatcac tgccatgttg aaaactcaga ctgcttttgt   3480

gatgtttcaa atgaataaaa ctatcctccc ctcgtta                            3517


<210>  22
<211>  3445
<212>  DNA
<213>  Homo sapiens

<400> 22

acgcggctgc acggaccgcc aatgctgctg cctcccagag cagagggagg cagaagagga     60

gggagggaga agagtggaag ggagggggag gcggcacttg ggctgcagct cgcaaccaga    120

ggcagtgtct ctcagctctc ggaaggaccg agagaggcaa ccgcggagta ggatgctctg    180

cggggcgccc agagccgggg gcgcttgaag cagcttcggg gactggggca accgggcagt    240

tttcaccatg catcagtccc tgactcagca gcggtccagc gacatgtccc tgcccgattc    300

catgggagca ttcaatcgga ggaaacgaaa ctccatctat gtcaccgtga ctttgcttat    360

tgtgtccgtg ttaattctca cagtgggcct tgctgcaacc accaggaccc agaatgtgac    420

tgtaggaggt tattaccccg gagttattct cggctttgga tcgttccttg gaatcattgg    480

atcaaacctt attgagaaca aaaggcagat gctggtggct tctatcgtgt ttatcagctt    540

tggtgtgatt gcggcttttt gttgtgccat agttgacggg gtctttgctg ccagacacat    600

tgatctgaaa ccactctacg ctaaccggtg ccattatgtt cccaagacat cacagaagga    660

agctgaggag gttaactgcc ctcacctcag ccgtgaattc tgcacacctc gcatccgggg    720

caacacctgc ttctgctgtg acctctacaa ctgtggcaac cgggtggaga tcactggtgg    780

gtactacgaa tacatcgatg tcagcagttg ccaagatatc atccacctct accacctgct    840

ctggtctgcc accatcctca acattgttgg cctgttcctg ggcatcatca ctgccgctgt    900

ccttggaggc tttaaggaca tgaacccaac tctcccagca ctgaactgtt ctgttgaaaa    960

tacccatcca acagtttctt actatgctca tccccaagtg gcatcctaca atacctacta   1020

ccatagccct cctcacctgc caccatattc tgcttatgac tttcagcatt ccggtgtctt   1080

tccatcctcc cctccctctg gactttctga tgagccccag tctgcctctc cctcacccag   1140

ctacatgtgg tcctcaagtg caccgccccg ttactctcca ccctactatc caccttttga   1200

aaagccacca ccttacagtc cctaaagagg aatgcctgct ggctattgag attattgtgg   1260

cttttgtatt tctgcttcag tggaagtgtg tagggtacaa aatttaaagt gtgactctta   1320

tgcataaagt tttacaatgg cctgccaggc tagggaaaga tagggacgaa gcttattcat   1380

tattagtgca gagcaggggt ggtcaggctg aacgcagcac agaagggcag ctcacattct   1440

ctaagcaaga ctggggagcc agcccagcaa gaagcttgtt tggacttgca ttaccctatg   1500

ctccacctct gtattcagca gaagtgtggt tgccatcttt ttcactttat gtaaaggagt   1560

gttgccctcg ggcccttggc agattgccac cccagcacct aggttgaagc acctggttta   1620

taggccctat ctttccctac ccctaaagtc agtccctaag gacaatttcc cagctgatgg   1680

ggctacacag tagttccaat acagagagtt ctggctaaga ttttgtttgc ttgtgtctgg   1740

atgttgaaaa agactgcccg tatctcttac tccttccttc tctgtgagta ttgtaaaaat   1800

ggctgttgtg atcactcagc tcagcttttg ttattggtac ctcctaaagg gaaaagtgca   1860

atattcttgc atcttcagta gtggggaaca ggatgtattg ttccggaaac actgaaatac   1920

acagcaacat gtgagatgtt ttaagtagat cacttaggag acagtggttc tactacatgt   1980

tgcattatta caaaatacat ttgctacagg agatataaat cttatggttg taattcagag   2040

tttaaaaatg ttataaatta ggttcttggg tcgtgatatg aattgttact aatctttgtg   2100

actatttaat cttcaaatat tgtgcttaac cccagcaatc cgcacgtatc ctgcacccca   2160

ccccaaaaga gtcatctgta ttttaatgcc actggtctta tcggtccttt tgtctgttga   2220

gaccagtcat gacagcattc aagattatga aagtgttaca atgccgcttc aagtctgcaa   2280

aacctcaaac gtagccaact tgacaaatat ttaagtgtta cggcagattt aaaatccatc   2340

tggcacaccg tggtaggtat ttgtacagtt cttttaatta cacatagctt taaaccatca   2400

acctgatgag tttaaagctt ttgcacccat gccttcactt cagaatgaac accttcattg   2460

tgatcttatg ttaacctgag aattgattta aaggaagatt gataatccta tactttataa   2520

cgtaaaaata caggggctac aggagggtac ctaattagac agttctccaa acacagaaca   2580

cacactggaa aattttccgg ccaattttgc tacctcccaa cttgatggat tagaggtagc   2640

gcaaatgctg gtgctcccat ctaccttgta gacacttagc catcaagaat caaggcacaa   2700

gaagtgcact ctctcattaa cagtaaatgt ttgcaagata ttcagtttaa ctttcagcat   2760

catgaatgtt cttatccaga ttttgaatcc gaaaaactat aatcctttta tgttatacaa   2820

aattactatg attttttaca gttctgagca tattaaaatt ctactggatt tcaaaaagag   2880

actaataccc aactgactaa ctaaacaaat atcaacttgt aatactcaat gaattttttt   2940

gccatttaca tttgaccgtt ggctttagtg aatgtccata tttaattttt taaggcacca   3000

ttacacagtt tatcctacat ttatcacatt tcttaaagtg ttaagattct atggctcatt   3060

tctatgtatt tttcttactt tacaaaataa cctgaaacag tatagatttt gtaacactta   3120

atttgagcag cttttttatt acattgaatt atataaagtg catgttacct tagaaaaatt   3180

aatatttgct gctttactct tttgcaaaac atttgctgta atgaatggat ttgtatttcc   3240

aatatgtatc ttgactgcat tttgtaatat ttactgcttt attcctaatt ctgctttaaa   3300

gtactgaact gggcatgaaa cattaaaata ttaatccaga aactgtataa actggatgtt   3360

gcttaaaatc tgtatcactg ccatgttgaa aactcagact gcttttgtga tgtttcaaat   3420

gaataaaact atcctcccct cgtta                                         3445


<210>  23
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 23

gtaagccgcc tccacttcct actcctggga aggaggatcg caaaagctg                 49


<210>  24
<211>  3193
<212>  DNA
<213>  Homo sapiens

<400> 24

acgcggctgc acggaccgcc aatgctgctg cctcccagag cagagggagg cagaagagga     60

gggagggaga agagtggaag ggagggggag gcggcacttg ggctgcagct cgcaaccaga    120

ggcagtgtct ctcagctctc ggaaggaccg agagaggcaa ccgcggagta ggatgctctg    180

cggggcgccc agagccgggg gcgcttgaag cagcttcggg gactggggca accgggcagt    240

tttcaccatg catcagtccc tgactcagca gcggtccagc gacatgtccc tgcccgattc    300

catgggagca ttcaatcgga ggaaacgaaa ctccatctat gtcaccgtga ctttgcttat    360

tgtgtccgtg ttaattctca cagtgggcct tgctgcaacc accaggaccc agaatgtgac    420

tgtaggaggt tattaccccg gagttattct cggctttgga tcgttccttg gaatcattgg    480

atcaaacctt attgagaaca aaaggcagat gctggtggct tctatcgtgt ttatcagctt    540

tggtgtgatt gcggcttttt gttgtgccat agttgacggg gtctttgctg ccagacacat    600

tgatctgaaa ccactctacg ctaaccggtg ccattatgtt cccaagacat cacagaagga    660

agctgaggag aacccaactc tcccagcact gaactgttct gttgaaaata cccatccaac    720

agtttcttac tatgctcatc cccaagtggc atcctacaat acctactacc atagccctcc    780

tcacctgcca ccatattctg cttatgactt tcagcattcc ggtgtctttc catcctcccc    840

tccctctgga ctttctgatg agccccagtc tgcctctccc tcacccagct acatgtggtc    900

ctcaagtgca ccgccccgtt actctccacc ctactatcca ccttttgaaa agccaccacc    960

ttacagtccc taaagaggaa tgcctgctgg ctattgagat tattgtggct tttgtatttc   1020

tgcttcagtg gaagtgtgta gggtacaaaa tttaaagtgt gactcttatg cataaagttt   1080

tacaatggcc tgccaggcta gggaaagata gggacgaagc ttattcatta ttagtgcaga   1140

gcaggggtgg tcaggctgaa cgcagcacag aagggcagct cacattctct aagcaagact   1200

ggggagccag cccagcaaga agcttgtttg gacttgcatt accctatgct ccacctctgt   1260

attcagcaga agtgtggttg ccatcttttt cactttatgt aaaggagtgt tgccctcggg   1320

cccttggcag attgccaccc cagcacctag gttgaagcac ctggtttata ggccctatct   1380

ttccctaccc ctaaagtcag tccctaagga caatttccca gctgatgggg ctacacagta   1440

gttccaatac agagagttct ggctaagatt ttgtttgctt gtgtctggat gttgaaaaag   1500

actgcccgta tctcttactc cttccttctc tgtgagtatt gtaaaaatgg ctgttgtgat   1560

cactcagctc agcttttgtt attggtacct cctaaaggga aaagtgcaat attcttgcat   1620

cttcagtagt ggggaacagg atgtattgtt ccggaaacac tgaaatacac agcaacatgt   1680

gagatgtttt aagtagatca cttaggagac agtggttcta ctacatgttg cattattaca   1740

aaatacattt gctacaggag atataaatct tatggttgta attcagagtt taaaaatgtt   1800

ataaattagg ttcttgggtc gtgatatgaa ttgttactaa tctttgtgac tatttaatct   1860

tcaaatattg tgcttaaccc cagcaatccg cacgtatcct gcaccccacc ccaaaagagt   1920

catctgtatt ttaatgccac tggtcttatc ggtccttttg tctgttgaga ccagtcatga   1980

cagcattcaa gattatgaaa gtgttacaat gccgcttcaa gtctgcaaaa cctcaaacgt   2040

agccaacttg acaaatattt aagtgttacg gcagatttaa aatccatctg gcacaccgtg   2100

gtaggtattt gtacagttct tttaattaca catagcttta aaccatcaac ctgatgagtt   2160

taaagctttt gcacccatgc cttcacttca gaatgaacac cttcattgtg atcttatgtt   2220

aacctgagaa ttgatttaaa ggaagattga taatcctata ctttataacg taaaaataca   2280

ggggctacag gagggtacct aattagacag ttctccaaac acagaacaca cactggaaaa   2340

ttttccggcc aattttgcta cctcccaact tgatggatta gaggtagcgc aaatgctggt   2400

gctcccatct accttgtaga cacttagcca tcaagaatca aggcacaaga agtgcactct   2460

ctcattaaca gtaaatgttt gcaagatatt cagtttaact ttcagcatca tgaatgttct   2520

tatccagatt ttgaatccga aaaactataa tccttttatg ttatacaaaa ttactatgat   2580

tttttacagt tctgagcata ttaaaattct actggatttc aaaaagagac taatacccaa   2640

ctgactaact aaacaaatat caacttgtaa tactcaatga atttttttgc catttacatt   2700

tgaccgttgg ctttagtgaa tgtccatatt taatttttta aggcaccatt acacagttta   2760

tcctacattt atcacatttc ttaaagtgtt aagattctat ggctcatttc tatgtatttt   2820

tcttacttta caaaataacc tgaaacagta tagattttgt aacacttaat ttgagcagct   2880

tttttattac attgaattat ataaagtgca tgttacctta gaaaaattaa tatttgctgc   2940

tttactcttt tgcaaaacat ttgctgtaat gaatggattt gtatttccaa tatgtatctt   3000

gactgcattt tgtaatattt actgctttat tcctaattct gctttaaagt actgaactgg   3060

gcatgaaaca ttaaaatatt aatccagaaa ctgtataaac tggatgttgc ttaaaatctg   3120

tatcactgcc atgttgaaaa ctcagactgc ttttgtgatg tttcaaatga ataaaactat   3180

cctcccctcg tta                                                      3193


<210>  25
<211>  165
<212>  PRT
<213>  Homo sapiens

<400> 25

Leu Cys Ser Leu Ser Ser Leu Thr Pro Pro Cys Gly Arg Arg Leu Val 
1               5                   10                  15      

Pro Cys Leu Ser Ala Pro Ala Pro Asn Ala Pro Arg Leu Pro Ala Pro 
            20                  25                  30          

Ala Arg Cys Ser Ile Gly Ala Leu Ile Gly Leu Ser Val Ala Ala Val 
        35                  40                  45              

Val Leu Leu Ala Phe Ile Val Thr Ala Cys Val Leu Cys Tyr Leu Phe 
    50                  55                  60                  

Ile Ser Ser Lys Pro His Thr Lys Leu Asp Leu Gly Leu Ser Leu Gln 
65                  70                  75                  80  

Thr Ala Gly Pro Glu Glu Val Ser Pro Asp Cys Gln Gly Val Asn Thr 
                85                  90                  95      

Gly Met Ala Ala Glu Val Pro Lys Val Ser Pro Leu Gln Gln Ser Tyr 
            100                 105                 110         

Ser Cys Leu Asn Pro Gln Leu Glu Ser Asn Glu Gly Gln Ala Val Asn 
        115                 120                 125             

Ser Lys Arg Leu Leu His His Cys Phe Met Ala Thr Val Thr Thr Ser 
    130                 135                 140                 

Asp Ile Pro Gly Ser Pro Glu Glu Ala Ser Val Pro Asn Pro Asp Leu 
145                 150                 155                 160 

Cys Gly Pro Val Pro 
                165 


<210>  26
<211>  3454
<212>  DNA
<213>  Homo sapiens

<400> 26

acgcggctgc acggaccgcc aatgctgctg cctcccagag cagagggagg cagaagagga     60

gggagggaga agagtggaag ggagggggag gcggcacttg ggctgcagct cgcaaccaga    120

ggcagtgtct ctcagctctc ggaaggaccg agagaggcaa ccgcggagta ggatgctctg    180

cggggcgccc agagccgggg gcgcttgaag cagcttcggg gactggggca accgggcagt    240

tttcaccatg catcagtccc tgactcagca gcggtccagc gacatgtccc tgcccgattc    300

catgggagca ttcaatcgga ggaaacgaaa ctccatctat gtcaccgtga ctttgcttat    360

tgtgtccgtg ttaattctca cagtgggcct tgctgcaacc accaggaccc agaatgtgac    420

tgtaggaggt tattaccccg gagttattct ggtggcttct atcgtgttta tcagctttgg    480

tgtgattgcg gctttttgtt gtgccatagt tgacggggtc tttgctgcca gacacattga    540

tctgaaacca ctctacgcta accggtgcca ttatgttccc aagacatcac agaaggaagc    600

tgaggaggtc ataagttcct caaccaaaaa ttctccttcc acgagggtta tgaggaacct    660

tacccaggca gctagagagg ttaactgccc tcacctcagc cgtgaattct gcacacctcg    720

catccggggc aacacctgct tctgctgtga cctctacaac tgtggcaacc gggtggagat    780

cactggtggg tactacgaat acatcgatgt cagcagttgc caagatatca tccacctcta    840

ccacctgctc tggtctgcca ccatcctcaa cattgttggc ctgttcctgg gcatcatcac    900

tgccgctgtc cttggaggct ttaaggacat gaacccaact ctcccagcac tgaactgttc    960

tgttgaaaat acccatccaa cagtttctta ctatgctcat ccccaagtgg catcctacaa   1020

tacctactac catagccctc ctcacctgcc accatattct gcttatgact ttcagcattc   1080

cggtgtcttt ccatcctccc ctccctctgg actttctgat gagccccagt ctgcctctcc   1140

ctcacccagc tacatgtggt cctcaagtgc accgccccgt tactctccac cctactatcc   1200

accttttgaa aagccaccac cttacagtcc ctaaagagga atgcctgctg gctattgaga   1260

ttattgtggc ttttgtattt ctgcttcagt ggaagtgtgt agggtacaaa atttaaagtg   1320

tgactcttat gcataaagtt ttacaatggc ctgccaggct agggaaagat agggacgaag   1380

cttattcatt attagtgcag agcaggggtg gtcaggctga acgcagcaca gaagggcagc   1440

tcacattctc taagcaagac tggggagcca gcccagcaag aagcttgttt ggacttgcat   1500

taccctatgc tccacctctg tattcagcag aagtgtggtt gccatctttt tcactttatg   1560

taaaggagtg ttgccctcgg gcccttggca gattgccacc ccagcaccta ggttgaagca   1620

cctggtttat aggccctatc tttccctacc cctaaagtca gtccctaagg acaatttccc   1680

agctgatggg gctacacagt agttccaata cagagagttc tggctaagat tttgtttgct   1740

tgtgtctgga tgttgaaaaa gactgcccgt atctcttact ccttccttct ctgtgagtat   1800

tgtaaaaatg gctgttgtga tcactcagct cagcttttgt tattggtacc tcctaaaggg   1860

aaaagtgcaa tattcttgca tcttcagtag tggggaacag gatgtattgt tccggaaaca   1920

ctgaaataca cagcaacatg tgagatgttt taagtagatc acttaggaga cagtggttct   1980

actacatgtt gcattattac aaaatacatt tgctacagga gatataaatc ttatggttgt   2040

aattcagagt ttaaaaatgt tataaattag gttcttgggt cgtgatatga attgttacta   2100

atctttgtga ctatttaatc ttcaaatatt gtgcttaacc ccagcaatcc gcacgtatcc   2160

tgcaccccac cccaaaagag tcatctgtat tttaatgcca ctggtcttat cggtcctttt   2220

gtctgttgag accagtcatg acagcattca agattatgaa agtgttacaa tgccgcttca   2280

agtctgcaaa acctcaaacg tagccaactt gacaaatatt taagtgttac ggcagattta   2340

aaatccatct ggcacaccgt ggtaggtatt tgtacagttc ttttaattac acatagcttt   2400

aaaccatcaa cctgatgagt ttaaagcttt tgcacccatg ccttcacttc agaatgaaca   2460

ccttcattgt gatcttatgt taacctgaga attgatttaa aggaagattg ataatcctat   2520

actttataac gtaaaaatac aggggctaca ggagggtacc taattagaca gttctccaaa   2580

cacagaacac acactggaaa attttccggc caattttgct acctcccaac ttgatggatt   2640

agaggtagcg caaatgctgg tgctcccatc taccttgtag acacttagcc atcaagaatc   2700

aaggcacaag aagtgcactc tctcattaac agtaaatgtt tgcaagatat tcagtttaac   2760

tttcagcatc atgaatgttc ttatccagat tttgaatccg aaaaactata atccttttat   2820

gttatacaaa attactatga ttttttacag ttctgagcat attaaaattc tactggattt   2880

caaaaagaga ctaataccca actgactaac taaacaaata tcaacttgta atactcaatg   2940

aatttttttg ccatttacat ttgaccgttg gctttagtga atgtccatat ttaatttttt   3000

aaggcaccat tacacagttt atcctacatt tatcacattt cttaaagtgt taagattcta   3060

tggctcattt ctatgtattt ttcttacttt acaaaataac ctgaaacagt atagattttg   3120

taacacttaa tttgagcagc ttttttatta cattgaatta tataaagtgc atgttacctt   3180

agaaaaatta atatttgctg ctttactctt ttgcaaaaca tttgctgtaa tgaatggatt   3240

tgtatttcca atatgtatct tgactgcatt ttgtaatatt tactgcttta ttcctaattc   3300

tgctttaaag tactgaactg ggcatgaaac attaaaatat taatccagaa actgtataaa   3360

ctggatgttg cttaaaatct gtatcactgc catgttgaaa actcagactg cttttgtgat   3420

gtttcaaatg aataaaacta tcctcccctc gtta                               3454


<210>  27
<211>  108
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 27

gttgtgttca ctctcctcac tgaccccgcc gtgtggtcgc cggctggtgc cttgtctgtc     60

tgccccagcc ccgaatgccc cgagactccc ggcgccggct cggtgcag                 108


<210>  28
<211>  2880
<212>  DNA
<213>  Homo sapiens

<400> 28

catttgctat gaatattctc tataacaaag caagacaaat ttagcagcac ttcattgcat     60

ctggatgggg gagagagctg gacaatttct tgctaacaag agatggttaa ctgccctcac    120

ctcagccgtg aattctgcac acctcgcatc cggggcaaca cctgcttctg ctgtgacctc    180

tacaactgtg gcaaccgggt ggagatcact ggtgggtact acgaatacat cgatgtcagc    240

agttgccaag atatcatcca cctctaccac ctgctctggt ctgccaccat cctcaacatt    300

gttggcctgt tcctgggcat catcactgcc gctgtccttg gaggctttaa ggacatgaac    360

ccaactctcc cagcactgaa ctgttctgtt gaaaataccc atccaacagt ttcttactat    420

gctcatcccc aagtggcatc ctacaatacc tactaccata gccctcctca cctgccacca    480

tattctgctt atgactttca gcattccggt gtctttccat cctcccctcc ctctggactt    540

tctgatgagc cccagtctgc ctctccctca cccagctaca tgtggtcctc aagtgcaccg    600

ccccgttact ctccacccta ctatccacct tttgaaaagc caccacctta cagtccctaa    660

agaggaatgc ctgctggcta ttgagattat tgtggctttt gtatttctgc ttcagtggaa    720

gtgtgtaggg tacaaaattt aaagtgtgac tcttatgcat aaagttttac aatggcctgc    780

caggctaggg aaagataggg acgaagctta ttcattatta gtgcagagca ggggtggtca    840

ggctgaacgc agcacagaag ggcagctcac attctctaag caagactggg gagccagccc    900

agcaagaagc ttgtttggac ttgcattacc ctatgctcca cctctgtatt cagcagaagt    960

gtggttgcca tctttttcac tttatgtaaa ggagtgttgc cctcgggccc ttggcagatt   1020

gccaccccag cacctaggtt gaagcacctg gtttataggc cctatctttc cctaccccta   1080

aagtcagtcc ctaaggacaa tttcccagct gatggggcta cacagtagtt ccaatacaga   1140

gagttctggc taagattttg tttgcttgtg tctggatgtt gaaaaagact gcccgtatct   1200

cttactcctt ccttctctgt gagtattgta aaaatggctg ttgtgatcac tcagctcagc   1260

ttttgttatt ggtacctcct aaagggaaaa gtgcaatatt cttgcatctt cagtagtggg   1320

gaacaggatg tattgttccg gaaacactga aatacacagc aacatgtgag atgttttaag   1380

tagatcactt aggagacagt ggttctacta catgttgcat tattacaaaa tacatttgct   1440

acaggagata taaatcttat ggttgtaatt cagagtttaa aaatgttata aattaggttc   1500

ttgggtcgtg atatgaattg ttactaatct ttgtgactat ttaatcttca aatattgtgc   1560

ttaaccccag caatccgcac gtatcctgca ccccacccca aaagagtcat ctgtatttta   1620

atgccactgg tcttatcggt ccttttgtct gttgagacca gtcatgacag cattcaagat   1680

tatgaaagtg ttacaatgcc gcttcaagtc tgcaaaacct caaacgtagc caacttgaca   1740

aatatttaag tgttacggca gatttaaaat ccatctggca caccgtggta ggtatttgta   1800

cagttctttt aattacacat agctttaaac catcaacctg atgagtttaa agcttttgca   1860

cccatgcctt cacttcagaa tgaacacctt cattgtgatc ttatgttaac ctgagaattg   1920

atttaaagga agattgataa tcctatactt tataacgtaa aaatacaggg gctacaggag   1980

ggtacctaat tagacagttc tccaaacaca gaacacacac tggaaaattt tccggccaat   2040

tttgctacct cccaacttga tggattagag gtagcgcaaa tgctggtgct cccatctacc   2100

ttgtagacac ttagccatca agaatcaagg cacaagaagt gcactctctc attaacagta   2160

aatgtttgca agatattcag tttaactttc agcatcatga atgttcttat ccagattttg   2220

aatccgaaaa actataatcc ttttatgtta tacaaaatta ctatgatttt ttacagttct   2280

gagcatatta aaattctact ggatttcaaa aagagactaa tacccaactg actaactaaa   2340

caaatatcaa cttgtaatac tcaatgaatt tttttgccat ttacatttga ccgttggctt   2400

tagtgaatgt ccatatttaa ttttttaagg caccattaca cagtttatcc tacatttatc   2460

acatttctta aagtgttaag attctatggc tcatttctat gtatttttct tactttacaa   2520

aataacctga aacagtatag attttgtaac acttaatttg agcagctttt ttattacatt   2580

gaattatata aagtgcatgt taccttagaa aaattaatat ttgctgcttt actcttttgc   2640

aaaacatttg ctgtaatgaa tggatttgta tttccaatat gtatcttgac tgcattttgt   2700

aatatttact gctttattcc taattctgct ttaaagtact gaactgggca tgaaacatta   2760

aaatattaat ccagaaactg tataaactgg atgttgctta aaatctgtat cactgccatg   2820

ttgaaaactc agactgcttt tgtgatgttt caaatgaata aaactatcct cccctcgtta   2880


<210>  29
<211>  349
<212>  PRT
<213>  Homo sapiens

<400> 29

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          

Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              

Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  

Gly Val Ile Leu Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ser Asn 
65                  70                  75                  80  

Leu Ile Glu Asn Lys Arg Gln Met Leu Val Ala Ser Ile Val Phe Ile 
                85                  90                  95      

Ser Phe Gly Val Ile Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val 
            100                 105                 110         

Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys 
        115                 120                 125             

His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu Val Ile Ser 
    130                 135                 140                 

Ser Ser Thr Lys Asn Ser Pro Ser Thr Arg Val Met Arg Asn Leu Thr 
145                 150                 155                 160 

Gln Ala Ala Arg Glu Val Asn Cys Pro His Leu Ser Arg Glu Phe Cys 
                165                 170                 175     

Thr Pro Arg Ile Arg Gly Asn Thr Cys Phe Cys Cys Asp Leu Tyr Asn 
            180                 185                 190         

Cys Gly Asn Arg Val Glu Ile Thr Gly Gly Tyr Tyr Glu Tyr Ile Asp 
        195                 200                 205             

Val Ser Ser Cys Gln Asp Ile Ile His Leu Tyr His Leu Leu Trp Ser 
    210                 215                 220                 

Ala Thr Ile Leu Asn Ile Val Gly Leu Phe Leu Gly Ile Ile Thr Ala 
225                 230                 235                 240 

Ala Val Leu Gly Gly Phe Lys Asp Met Asn Pro Thr Leu Pro Ala Leu 
                245                 250                 255     

Asn Cys Ser Val Glu Asn Thr His Pro Thr Val Ser Tyr Tyr Ala His 
            260                 265                 270         

Pro Gln Val Ala Ser Tyr Asn Thr Tyr Tyr His Ser Pro Pro His Leu 
        275                 280                 285             

Pro Pro Tyr Ser Ala Tyr Asp Phe Gln His Ser Gly Val Phe Pro Ser 
    290                 295                 300                 

Ser Pro Pro Ser Gly Leu Ser Asp Glu Pro Gln Ser Ala Ser Pro Ser 
305                 310                 315                 320 

Pro Ser Tyr Met Trp Ser Ser Ser Ala Pro Pro Arg Tyr Ser Pro Pro 
                325                 330                 335     

Tyr Tyr Pro Pro Phe Glu Lys Pro Gln Pro Tyr Ser Pro 
            340                 345                 


<210>  30
<211>  349
<212>  PRT
<213>  Homo sapiens

<400> 30

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          

Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              

Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  

Gly Val Ile Leu Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ser Asn 
65                  70                  75                  80  

Leu Ile Glu Asn Lys Arg Gln Met Leu Val Ala Ser Ile Val Phe Ile 
                85                  90                  95      

Ser Phe Gly Val Ile Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val 
            100                 105                 110         

Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys 
        115                 120                 125             

His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu Val Ile Ser 
    130                 135                 140                 

Ser Ser Thr Lys Asn Ser Pro Ser Thr Arg Val Met Arg Asn Leu Thr 
145                 150                 155                 160 

Gln Ala Ala Arg Glu Val Asn Cys Pro His Leu Ser Arg Glu Phe Cys 
                165                 170                 175     

Thr Pro Arg Ile Arg Gly Asn Thr Cys Phe Cys Cys Asp Leu Tyr Asn 
            180                 185                 190         

Cys Gly Asn Arg Val Glu Ile Thr Gly Gly Tyr Tyr Glu Tyr Ile Asp 
        195                 200                 205             

Val Ser Ser Cys Gln Asp Ile Ile His Leu Tyr His Leu Leu Trp Ser 
    210                 215                 220                 

Ala Thr Ile Leu Asn Ile Val Gly Leu Phe Leu Gly Ile Ile Thr Ala 
225                 230                 235                 240 

Ala Val Leu Gly Gly Phe Lys Asp Met Asn Pro Thr Leu Pro Ala Leu 
                245                 250                 255     

Asn Cys Ser Val Glu Asn Thr His Pro Thr Val Ser Tyr Tyr Ala His 
            260                 265                 270         

Pro Gln Val Ala Ser Tyr Asn Thr Tyr Tyr His Ser Pro Pro His Leu 
        275                 280                 285             

Pro Pro Tyr Ser Ala Tyr Asp Phe Gln His Ser Gly Val Phe Pro Ser 
    290                 295                 300                 

Ser Pro Pro Ser Gly Leu Ser Asp Glu Pro Gln Ser Ala Ser Pro Ser 
305                 310                 315                 320 

Pro Ser Tyr Met Trp Ser Ser Ser Ala Pro Pro Arg Tyr Ser Pro Pro 
                325                 330                 335     

Tyr Tyr Pro Pro Phe Glu Lys Pro Pro Pro Tyr Ser Pro 
            340                 345                 


<210>  31
<211>  349
<212>  PRT
<213>  Homo sapiens

<400> 31

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          

Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              

Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  

Gly Val Ile Leu Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ser Asn 
65                  70                  75                  80  

Leu Ile Glu Asn Lys Arg Gln Met Leu Val Ala Ser Ile Val Phe Ile 
                85                  90                  95      

Ser Phe Gly Val Ile Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val 
            100                 105                 110         

Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys 
        115                 120                 125             

His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu Val Ile Ser 
    130                 135                 140                 

Ser Ser Thr Lys Asn Ser Pro Ser Thr Arg Val Met Arg Asn Leu Thr 
145                 150                 155                 160 

Gln Ala Ala Arg Glu Val Asn Cys Pro His Leu Ser Arg Glu Phe Cys 
                165                 170                 175     

Thr Pro Arg Ile Arg Gly Asn Thr Cys Phe Cys Cys Asp Leu Tyr Asn 
            180                 185                 190         

Cys Gly Asn Arg Val Glu Ile Thr Gly Gly Tyr Tyr Glu Tyr Ile Asp 
        195                 200                 205             

Val Ser Ser Cys Gln Asp Ile Ile His Leu Tyr His Leu Leu Trp Ser 
    210                 215                 220                 

Ala Thr Ile Leu Asn Ile Val Gly Leu Phe Leu Gly Ile Ile Thr Ala 
225                 230                 235                 240 

Ala Val Leu Gly Gly Phe Lys Asp Met Asn Pro Thr Leu Pro Ala Leu 
                245                 250                 255     

Asn Cys Ser Val Glu Asn Thr His Pro Thr Val Ser Tyr Tyr Ala His 
            260                 265                 270         

Pro Gln Val Ala Ser Tyr Asn Thr Tyr Tyr His Ser Pro Pro His Leu 
        275                 280                 285             

Pro Pro Tyr Ser Ala Tyr Asp Phe Gln His Ser Gly Val Phe Pro Ser 
    290                 295                 300                 

Ser Pro Pro Ser Gly Leu Ser Asp Glu Pro Gln Ser Ala Ser Ser Ser 
305                 310                 315                 320 

Pro Ser Tyr Met Trp Ser Ser Ser Ala Pro Pro Arg Tyr Ser Pro Pro 
                325                 330                 335     

Tyr Tyr Pro Pro Phe Glu Lys Pro Pro Pro Tyr Ser Pro 
            340                 345                 


<210>  32
<211>  185
<212>  PRT
<213>  Homo sapiens

<400> 32

Met Val Asn Cys Pro His Leu Ser Arg Glu Phe Cys Thr Pro Arg Ile 
1               5                   10                  15      

Arg Gly Asn Thr Cys Phe Cys Cys Asp Leu Tyr Asn Cys Gly Asn Arg 
            20                  25                  30          

Val Glu Ile Thr Gly Gly Tyr Tyr Glu Tyr Ile Asp Val Ser Ser Cys 
        35                  40                  45              

Gln Asp Ile Ile His Leu Tyr His Leu Leu Trp Ser Ala Thr Ile Leu 
    50                  55                  60                  

Asn Ile Val Gly Leu Phe Leu Gly Ile Ile Thr Ala Ala Val Leu Gly 
65                  70                  75                  80  

Gly Phe Lys Asp Met Asn Pro Thr Leu Pro Ala Leu Asn Cys Ser Val 
                85                  90                  95      

Glu Asn Thr His Pro Thr Val Ser Tyr Tyr Ala His Pro Gln Val Ala 
            100                 105                 110         

Ser Tyr Asn Thr Tyr Tyr His Ser Pro Pro His Leu Pro Pro Tyr Ser 
        115                 120                 125             

Ala Tyr Asp Phe Gln His Ser Gly Val Phe Pro Ser Ser Pro Pro Ser 
    130                 135                 140                 

Gly Leu Ser Asp Glu Pro Gln Ser Ala Ser Pro Ser Pro Ser Tyr Met 
145                 150                 155                 160 

Trp Ser Ser Ser Ala Pro Pro Arg Tyr Ser Pro Pro Tyr Tyr Pro Pro 
                165                 170                 175     

Phe Glu Lys Pro Pro Pro Tyr Ser Pro 
            180                 185 


<210>  33
<211>  325
<212>  PRT
<213>  Homo sapiens

<400> 33

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          

Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              

Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  

Gly Val Ile Leu Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ser Asn 
65                  70                  75                  80  

Leu Ile Glu Asn Lys Arg Gln Met Leu Val Ala Ser Ile Val Phe Ile 
                85                  90                  95      

Ser Phe Gly Val Ile Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val 
            100                 105                 110         

Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys 
        115                 120                 125             

His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu Val Asn Cys 
    130                 135                 140                 

Pro His Leu Ser Arg Glu Phe Cys Thr Pro Arg Ile Arg Gly Asn Thr 
145                 150                 155                 160 

Cys Phe Cys Cys Asp Leu Tyr Asn Cys Gly Asn Arg Val Glu Ile Thr 
                165                 170                 175     

Gly Gly Tyr Tyr Glu Tyr Ile Asp Val Ser Ser Cys Gln Asp Ile Ile 
            180                 185                 190         

His Leu Tyr His Leu Leu Trp Ser Ala Thr Ile Leu Asn Ile Val Gly 
        195                 200                 205             

Leu Phe Leu Gly Ile Ile Thr Ala Ala Val Leu Gly Gly Phe Lys Asp 
    210                 215                 220                 

Met Asn Pro Thr Leu Pro Ala Leu Asn Cys Ser Val Glu Asn Thr His 
225                 230                 235                 240 

Pro Thr Val Ser Tyr Tyr Ala His Pro Gln Val Ala Ser Tyr Asn Thr 
                245                 250                 255     

Tyr Tyr His Ser Pro Pro His Leu Pro Pro Tyr Ser Ala Tyr Asp Phe 
            260                 265                 270         

Gln His Ser Gly Val Phe Pro Ser Ser Pro Pro Ser Gly Leu Ser Asp 
        275                 280                 285             

Glu Pro Gln Ser Ala Ser Pro Ser Pro Ser Tyr Met Trp Ser Ser Ser 
    290                 295                 300                 

Ala Pro Pro Arg Tyr Ser Pro Pro Tyr Tyr Pro Pro Phe Glu Lys Pro 
305                 310                 315                 320 

Pro Pro Tyr Ser Pro 
                325 


<210>  34
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 34

aatcattatg ctgaggattt ggaaa                                           25


<210>  35
<211>  241
<212>  PRT
<213>  Homo sapiens

<400> 35

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          

Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              

Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  

Gly Val Ile Leu Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ser Asn 
65                  70                  75                  80  

Leu Ile Glu Asn Lys Arg Gln Met Leu Val Ala Ser Ile Val Phe Ile 
                85                  90                  95      

Ser Phe Gly Val Ile Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val 
            100                 105                 110         

Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys 
        115                 120                 125             

His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu Asn Pro Thr 
    130                 135                 140                 

Leu Pro Ala Leu Asn Cys Ser Val Glu Asn Thr His Pro Thr Val Ser 
145                 150                 155                 160 

Tyr Tyr Ala His Pro Gln Val Ala Ser Tyr Asn Thr Tyr Tyr His Ser 
                165                 170                 175     

Pro Pro His Leu Pro Pro Tyr Ser Ala Tyr Asp Phe Gln His Ser Gly 
            180                 185                 190         

Val Phe Pro Ser Ser Pro Pro Ser Gly Leu Ser Asp Glu Pro Gln Ser 
        195                 200                 205             

Ala Ser Pro Ser Pro Ser Tyr Met Trp Ser Ser Ser Ala Pro Pro Arg 
    210                 215                 220                 

Tyr Ser Pro Pro Tyr Tyr Pro Pro Phe Glu Lys Pro Pro Pro Tyr Ser 
225                 230                 235                 240 

Pro 
<210>  36

<211>  328
<212>  PRT
<213>  Homo sapiens

<400> 36

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          

Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              

Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  

Gly Val Ile Leu Val Ala Ser Ile Val Phe Ile Ser Phe Gly Val Ile 
65                  70                  75                  80  

Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val Phe Ala Ala Arg His 
                85                  90                  95      

Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys His Tyr Val Pro Lys 
            100                 105                 110         

Thr Ser Gln Lys Glu Ala Glu Glu Val Ile Ser Ser Ser Thr Lys Asn 
        115                 120                 125             

Ser Pro Ser Thr Arg Val Met Arg Asn Leu Thr Gln Ala Ala Arg Glu 
    130                 135                 140                 

Val Asn Cys Pro His Leu Ser Arg Glu Phe Cys Thr Pro Arg Ile Arg 
145                 150                 155                 160 

Gly Asn Thr Cys Phe Cys Cys Asp Leu Tyr Asn Cys Gly Asn Arg Val 
                165                 170                 175     

Glu Ile Thr Gly Gly Tyr Tyr Glu Tyr Ile Asp Val Ser Ser Cys Gln 
            180                 185                 190         

Asp Ile Ile His Leu Tyr His Leu Leu Trp Ser Ala Thr Ile Leu Asn 
        195                 200                 205             

Ile Val Gly Leu Phe Leu Gly Ile Ile Thr Ala Ala Val Leu Gly Gly 
    210                 215                 220                 

Phe Lys Asp Met Asn Pro Thr Leu Pro Ala Leu Asn Cys Ser Val Glu 
225                 230                 235                 240 

Asn Thr His Pro Thr Val Ser Tyr Tyr Ala His Pro Gln Val Ala Ser 
                245                 250                 255     

Tyr Asn Thr Tyr Tyr His Ser Pro Pro His Leu Pro Pro Tyr Ser Ala 
            260                 265                 270         

Tyr Asp Phe Gln His Ser Gly Val Phe Pro Ser Ser Pro Pro Ser Gly 
        275                 280                 285             

Leu Ser Asp Glu Pro Gln Ser Ala Ser Pro Ser Pro Ser Tyr Met Trp 
    290                 295                 300                 

Ser Ser Ser Ala Pro Pro Arg Tyr Ser Pro Pro Tyr Tyr Pro Pro Phe 
305                 310                 315                 320 

Glu Lys Pro Pro Pro Tyr Ser Pro 
                325             


<210>  37
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 37

cctcccatct ccttcatcac at                                              22


<210>  38
<211>  3349
<212>  DNA
<213>  Homo sapiens

<400> 38

ggctggagag gcgtgataat agaaccagtg cttcaacagc aacttctctt ttgcaatcct     60

tgctggtctg acaggctcct gcagaattac atcacttcct aaaaaacagg cacacacctc    120

tccttcaagt cagcaccgac ccaaacaagc aggaaacagg aaatgttcac gtttcagaga    180

ggctgcagcc cggcgcagca tcctgagcgc gcctctgccg aggcgagcgg acatgcaggc    240

tccccgcgca gccctagtct tcgccctggt gatcgcgctc gttcccgtcg gccggggtaa    300

ttatgaggaa ttagaaaact caggagatac aactgtggaa tctgaaagac caaataaagt    360

gactattcca agcacatttg ctgcagtgac catcaaagaa acattaaatg caaatataaa    420

ttctaccaac tttgctccgg atgaaaatca gttagagttt atactgatgg tgttaatccc    480

attgatttta ttggtcctct tacttttatc cgtggtattc cttgcaacat actataaaag    540

aaaaagaact aaacaagaac cttctagcca aggatctcag agtgctttac agacatatga    600

actgggaagt gaaaacgtga aagtccctat ttttgaggaa gatacaccct ctgttatgga    660

aattgaaatg gaagagcttg ataaatggat gaacagcatg aatagaaatg ccgactttga    720

atgtttacct accttgaagg aagagaagga atcaaatcac aacccaagtg acagtgaatc    780

ctaaacctga atggcgctca tgttttccaa gagaagcagc ccctgaggga gtctgctgag    840

gctgccaaca gaggatgaag aggatacaaa tttaattaat ttcaaatcaa catagacaca    900

agaacctttt gctgtttctt ccaacgccca ctcttcctaa tgatggcatc acttgcactt    960

ggaagaatgt gcaattgaga agtactagga aaaggcctgg ctgccatcca tcgctgcctc   1020

tgagggtgga gaaggaggcg ggtgatgtgc tcacttctga tcaacatgtg ttgcctcctc   1080

tcagccaact tctagctcac tgcactcact ctggtcatga taaatgttcg tcacctttct   1140

gcttcattcc ttagggccta aatcaggaag ctgttttatc gatggtttcc ttttgggtca   1200

gtaaccagct ttggataatt tcctctgatt attcaagtcg tgggacaggt aaactacatt   1260

cagcaggaac ttttctcgag gagtgttatg tcatggaaaa gacaccaaac acagcaagta   1320

ttttaatgaa tacaccatcc cagggggtca gtaagctctg cctgccaaga agacacagtg   1380

agaggggtcc acagtcctga tgaggtggcg tttggtaact tgtagaccct agcatggcca   1440

ggtctggtca cccttaagaa cttctcagag aaactaggaa tcttcagtga aagaactaat   1500

gttctcctca gctgaaattc ccttgcttgt cagcatttct gcaaagctca cacttgtttc   1560

accatacctc ccttggatgt gacatgtagg taggaagtat gtgcaggtgg gagtcatctg   1620

tcagccttct atgtttcaga gatcctgaag gtggtttgaa acaaacagaa gaggagcagg   1680

aaatatccgt gcctgtggca gatctcactc atcatgctta gcattctctc ccgccaagct   1740

gggataagcc tcatgtccta acacagcaca acaggaggtc tctgtcagtc catcagagat   1800

gacattctat gtgatatttt tgacatcctt gtgctaaaag caatggcaca aaatggaaaa   1860

gggcctattg accacaccta ctccagtaaa attgttcttc atttattcct taattttcta   1920

aatctgaccc ctttaaagca atctagcaaa ttgagaatcc tcagctctcc ttggatacct   1980

gatattttat ttcaagaaag agacaaagaa ggaaaatttt atttatttta ctacccacat   2040

ataaaccgaa gggagatggg actacccaaa catttgctgc tcaattttgt gtcttgtgct   2100

tgaaagtctg ccctaatgca taacaaaaac tacttgtctc ctaccttttg ggatcccttt   2160

aacaagtatt tgccttctga actacgtgga taatttcaaa ggcagagttc cagaccagag   2220

aggtctttcc atacaatgaa agctataact agctggttgt gtttaaccac tgctatcacg   2280

ctatcctggg actgcataga actttgacaa aagacagact tcatggtaca caacttcaac   2340

agattttctg tcatattctc accagcacat ctgaatgagg ctttgtgttt tccttgctct   2400

cttgcatgtt ccttttcaac tcatggccca cagtgactct cagagattta tgccaaaatt   2460

gcatacaatt gttttctgaa tcataacttg tctatttttc tgcctatgtg tgctactttc   2520

agtttgtttc tcatcaacat tttgactctc agaagagcct ccatttgccc ctttctctct   2580

ttaggtatct aagatctttg aacacctgga cctttacatt tgatccaacc ctatcaaata   2640

atgaacttct cagagaggca tctggggtcc tggaacttca tgttgatgaa gtcatattat   2700

ataatatgat aaaaatattc tcatgcagta ttttaaataa tttcaaattc tagaagaagc   2760

aaatttcagc gacatgtcat tgagttttta tttggtaaag ctataattgt gcagtgtaca   2820

aagcactttt taaaaagata gtttattctg tcagggtata tgaagttagt atacagccag   2880

aacagccaag cctcaattct tgtaccttgt gtctttttat tactgtttaa tcaatagata   2940

tcatatgttt atgacagttt caagaattgt ttttaaaccc aaacttaatt ttatgtttca   3000

gactattgtt agaaaaacaa aacaaaaaac aaaaaaaccc tcactaattt gccctaattg   3060

gatagggcaa tcagaacaaa atctgacttt cgaatattta aaagatatgt aagtttgatt   3120

gcattttcgt acattttaag caaactaggt taacaacaac atagcctagt caaacttctc   3180

aggaaacttg ttttaataaa tatgtaaaaa tacccattca tgactcttga cccaatggtg   3240

tgactcctcc ctctgggaag ggctttgtta cccaatgcaa gaccacagcc tggatccacc   3300

ttgatgtagg tggctcctgg ataacccaca tcaaacaaat gtgataaag               3349


<210>  39
<211>  2767
<212>  DNA
<213>  Homo sapiens

<400> 39

ggctggagag gcgtgataat agaaccagtg cttcaacagc aacttctctt ttgcaatcct     60

tgctggtctg acaggctcct gcagaattac atcacttcct aaaaaacagg cacacacctc    120

tccttcaagt cagcaccgac ccaaacaagc aggaaacagg aaatgttcac gtttcagaga    180

ggctgcagcc cggcgcagca tcctgagcgc gcctctgccg aggcgagcgg acatgcaggc    240

tccccgcgca gccctagtct tcgccctggt gatcgcgctc gttcccgtcg gccggggtaa    300

ttatgaggaa ttagaaaact caggagatac aactgtggaa tctgaaagac caaataaagt    360

gactattcca agcacatttg ctgcagtgac catcaaagaa acattaaatg caaatataaa    420

ttctaccaac tttgctccgg atgaaaatca gttagagttt atactgatgg tgttaatccc    480

attgatttta ttggtcctct tacttttatc cgtggtattc cttgcaacat actataaaag    540

aaaaagaact aaacaagaac cttctagcca aggatctcag agtgctttac agacatatga    600

actgggaagt gaaaacgtga aagtccctat ttttgaggaa gatacaccct ctgttatgga    660

aattgaaatg gaagagcttg ataaatggat gaacagcatg aatagaaatg ccgactttga    720

atgtttacct accttgaagg aagagaagga atcaaatcac aacccaagtg acagtgaatc    780

ctaaacctga atggcgctca tgttttccaa gagaagcagc ccctgaggga gtctgctgag    840

gctgccaaca gaggatgaag aggatacaaa tttaattaat ttcaaatcaa catagacaca    900

agaacctttt gctgtttctt ccaacgccca ctcttcctaa tgatggcatc acttgcactt    960

ggaagaatgt gcaattgaga agtactagga aaaggcctgg ctgccatcca tcgctgcctc   1020

tgagggtgga gaaggaggcg ggtgatgtgc tcacttctga tcaacatgtg ttgcctcctc   1080

tcagccaact tctagctcac tgcactcact ctggtcatga taaatgttcg tcacctttct   1140

gcttcattcc ttagggccta aatcaggaag ctgttttatc gatggtttcc ttttgggtca   1200

gtaaccagct ttggataatt tcctctgatt attcaagtcg tgggacaggt aaactacatt   1260

cagcaggaac ttttctcgag gagtgttatg tcatggaaaa gacaccaaac acagcaagta   1320

ttttaatgaa tacaccatcc cagggggtca gtaagctctg cctgccaaga agacacagtg   1380

agaggggtcc acagtcctga tgaggtggcg tttggtaact tgtagaccct agcatggcca   1440

ggtctggtca cccttaagaa cttctcagag aaactaggaa tcttcagtga aagaactaat   1500

gttctcctca gctgaaattc ccttgcttgt cagcatttct gcaaagctca cacttgtttc   1560

accatacctc ccttggatgt gacatgtagg taggaagtat gtgcaggtgg gagtcatctg   1620

tcagccttct atgtttcaga gatcctgaag gtggtttgaa acaaacagaa gaggagcagg   1680

aaatatccgt gcctgtggca gatctcactc atcatgctta gcattctctc ccgccaagct   1740

gggataagcc tcatgtccta acacagcaca acaggaggtc tctgtcagtc catcagagat   1800

gacattctat gtgatatttt tgacatcctt gtgctaaaag caatggcaca aaatggaaaa   1860

gggcctattg accacaccta ctccagtaaa attgttcttc atttattcct taattttcta   1920

aatctgaccc ctttaaagca atctagcaaa ttgagaatcc tcagctctcc ttggatacct   1980

gatattttat ttcaagaaag agacaaagaa ggaaaatttt atttatttta ctacccacat   2040

ataaaccgaa gggagatggg actacccaaa catttgctgc tcaattttgt gtcttgtgct   2100

tgaaagtctg ccctaatgca taacaaaaac tacttgtctc ctaccttttg ggatcccttt   2160

aacaagtatt tgccttctga actacgtgga taatttcaaa ggcagagttc cagaccagag   2220

aggtctttcc atacaatgaa agctataact agctggttgt gtttaaccac tgctatcacg   2280

ctatcctggg actgcataga actttgacaa aagacagact tcatggtaca caacttcaac   2340

agattttctg tcatattctc accagcacat ctgaatgagg ctttgtgttt tccttgctct   2400

cttgcatgtt ccttttcaac tcatggccca cagtgactct cagagattta tgccaaaatt   2460

gcatacaatt gttttctgaa tcataacttg tctatttttc tgcctatgtg tgctactttc   2520

agtttgtttc tcatcaacat tttgactctc agaagagcct ccatttgccc ctttctctct   2580

ttaggtatct aagatctttg aacacctgga cctttacatt tgatccaacc ctatcaaata   2640

atgaacttct cagagaggca tctggggtcc tggaacttca tgttgatgaa gtcatattat   2700

ataatatgat aaaaatattc tcatgcagta ttttaaataa tttcaaattc tagaagaagc   2760

aaatttc                                                             2767


<210>  40
<211>  3398
<212>  DNA
<213>  Homo sapiens

<400> 40

ggctggagag gcgtgataat agaaccagtg cttcaacagc aacttctctt ttgcaatcct     60

tgctggtctg acaggctcct gcagaattac atcacttcct aaaaaacagg cacacacctc    120

tccttcaagt cagcaccgac ccaaacaagc aggaaacagg aaatgttcac gtttcagaga    180

ggctgcagcc cggcgcagca tcctgagcgc gcctctgccg aggcgagcgg acatgcaggc    240

tccccgcgca gccctagtct tcgccctggt gatcgcgctc gttcccgtcg gccggggtaa    300

gccgcctcca cttcctactc ctgggaagga ggatcgcaaa agctggtaat tatgaggaat    360

tagaaaactc aggagataca actgtggaat ctgaaagacc aaataaagtg actattccaa    420

gcacatttgc tgcagtgacc atcaaagaaa cattaaatgc aaatataaat tctaccaact    480

ttgctccgga tgaaaatcag ttagagttta tactgatggt gttaatccca ttgattttat    540

tggtcctctt acttttatcc gtggtattcc ttgcaacata ctataaaaga aaaagaacta    600

aacaagaacc ttctagccaa ggatctcaga gtgctttaca gacatatgaa ctgggaagtg    660

aaaacgtgaa agtccctatt tttgaggaag atacaccctc tgttatggaa attgaaatgg    720

aagagcttga taaatggatg aacagcatga atagaaatgc cgactttgaa tgtttaccta    780

ccttgaagga agagaaggaa tcaaatcaca acccaagtga cagtgaatcc taaacctgaa    840

tggcgctcat gttttccaag agaagcagcc cctgagggag tctgctgagg ctgccaacag    900

aggatgaaga ggatacaaat ttaattaatt tcaaatcaac atagacacaa gaaccttttg    960

ctgtttcttc caacgcccac tcttcctaat gatggcatca cttgcacttg gaagaatgtg   1020

caattgagaa gtactaggaa aaggcctggc tgccatccat cgctgcctct gagggtggag   1080

aaggaggcgg gtgatgtgct cacttctgat caacatgtgt tgcctcctct cagccaactt   1140

ctagctcact gcactcactc tggtcatgat aaatgttcgt cacctttctg cttcattcct   1200

tagggcctaa atcaggaagc tgttttatcg atggtttcct tttgggtcag taaccagctt   1260

tggataattt cctctgatta ttcaagtcgt gggacaggta aactacattc agcaggaact   1320

tttctcgagg agtgttatgt catggaaaag acaccaaaca cagcaagtat tttaatgaat   1380

acaccatccc agggggtcag taagctctgc ctgccaagaa gacacagtga gaggggtcca   1440

cagtcctgat gaggtggcgt ttggtaactt gtagacccta gcatggccag gtctggtcac   1500

ccttaagaac ttctcagaga aactaggaat cttcagtgaa agaactaatg ttctcctcag   1560

ctgaaattcc cttgcttgtc agcatttctg caaagctcac acttgtttca ccatacctcc   1620

cttggatgtg acatgtaggt aggaagtatg tgcaggtggg agtcatctgt cagccttcta   1680

tgtttcagag atcctgaagg tggtttgaaa caaacagaag aggagcagga aatatccgtg   1740

cctgtggcag atctcactca tcatgcttag cattctctcc cgccaagctg ggataagcct   1800

catgtcctaa cacagcacaa caggaggtct ctgtcagtcc atcagagatg acattctatg   1860

tgatattttt gacatccttg tgctaaaagc aatggcacaa aatggaaaag ggcctattga   1920

ccacacctac tccagtaaaa ttgttcttca tttattcctt aattttctaa atctgacccc   1980

tttaaagcaa tctagcaaat tgagaatcct cagctctcct tggatacctg atattttatt   2040

tcaagaaaga gacaaagaag gaaaatttta tttattttac tacccacata taaaccgaag   2100

ggagatggga ctacccaaac atttgctgct caattttgtg tcttgtgctt gaaagtctgc   2160

cctaatgcat aacaaaaact acttgtctcc taccttttgg gatcccttta acaagtattt   2220

gccttctgaa ctacgtggat aatttcaaag gcagagttcc agaccagaga ggtctttcca   2280

tacaatgaaa gctataacta gctggttgtg tttaaccact gctatcacgc tatcctggga   2340

ctgcatagaa ctttgacaaa agacagactt catggtacac aacttcaaca gattttctgt   2400

catattctca ccagcacatc tgaatgaggc tttgtgtttt ccttgctctc ttgcatgttc   2460

cttttcaact catggcccac agtgactctc agagatttat gccaaaattg catacaattg   2520

ttttctgaat cataacttgt ctatttttct gcctatgtgt gctactttca gtttgtttct   2580

catcaacatt ttgactctca gaagagcctc catttgcccc tttctctctt taggtatcta   2640

agatctttga acacctggac ctttacattt gatccaaccc tatcaaataa tgaacttctc   2700

agagaggcat ctggggtcct ggaacttcat gttgatgaag tcatattata taatatgata   2760

aaaatattct catgcagtat tttaaataat ttcaaattct agaagaagca aatttcagcg   2820

acatgtcatt gagtttttat ttggtaaagc tataattgtg cagtgtacaa agcacttttt   2880

aaaaagatag tttattctgt cagggtatat gaagttagta tacagccaga acagccaagc   2940

ctcaattctt gtaccttgtg tctttttatt actgtttaat caatagatat catatgttta   3000

tgacagtttc aagaattgtt tttaaaccca aacttaattt tatgtttcag actattgtta   3060

gaaaaacaaa acaaaaaaca aaaaaaccct cactaatttg ccctaattgg atagggcaat   3120

cagaacaaaa tctgactttc gaatatttaa aagatatgta agtttgattg cattttcgta   3180

cattttaagc aaactaggtt aacaacaaca tagcctagtc aaacttctca ggaaacttgt   3240

tttaataaat atgtaaaaat acccattcat gactcttgac ccaatggtgt gactcctccc   3300

tctgggaagg gctttgttac ccaatgcaag accacagcct ggatccacct tgatgtaggt   3360

ggctcctgga taacccacat caaacaaatg tgataaag                           3398


<210>  41
<211>  776
<212>  DNA
<213>  Homo sapiens

<400> 41

ggctggagag gcgtgataat agaaccagtg cttcaacagc aacttctctt ttgcaatcct     60

tgctggtctg acaggctcct gcagaattac atcacttcct aaaaaacagg cacacacctc    120

tccttcaagt cagcaccgac ccaaacaagc aggaaacagg aaatgttcac gtttcagaga    180

ggctgcagcc cggcgcagca tcctgagcgc gcctctgccg aggcgagcgg acatgcaggc    240

tccccgcgca gccctagtct tcgccctggt gatcgcgctc gttcccgtcg gccggggtaa    300

ttatgaggaa ttagaaaact caggagatac aactgtggaa tctgaaagac caaataaagt    360

gactattcca agcacatttg ctgcagtgac catcaaagaa acattaaatg caaatataaa    420

ttctaccaac tttgctccgg atgaaaatca gttagagttt atactgatgg tgttaatccc    480

attgatttta ttggtcctct tacttttatc cgtggtattc cttgcaacat actataaaag    540

aaaaagaact aaacaagaac cttctagcca aggatctcag agtgctttac agacatgtaa    600

aatacaacta tcatggaagg tcataccagc gttttgcttg gaaagctccc acagaaatgc    660

tttataggag agcatggaca cctgcacact atgtcccctg ggaagttaga agcagacata    720

ctgtttctta ctgcacttgg gtagagcctg gtctgttata ctatactagg aaataa        776


<210>  42
<211>  183
<212>  PRT
<213>  Homo sapiens

<400> 42

Met Gln Ala Pro Arg Ala Ala Leu Val Phe Ala Leu Val Ile Ala Leu 
1               5                   10                  15      

Val Pro Val Gly Arg Gly Asn Tyr Glu Glu Leu Glu Asn Ser Gly Asp 
            20                  25                  30          

Thr Thr Val Glu Ser Glu Arg Pro Asn Lys Val Thr Ile Pro Ser Thr 
        35                  40                  45              

Phe Ala Ala Val Thr Ile Lys Glu Thr Leu Asn Ala Asn Ile Asn Ser 
    50                  55                  60                  

Thr Asn Phe Ala Pro Asp Glu Asn Gln Leu Glu Phe Ile Leu Met Val 
65                  70                  75                  80  

Leu Ile Pro Leu Ile Leu Leu Val Leu Leu Leu Leu Ser Val Val Phe 
                85                  90                  95      

Leu Ala Thr Tyr Tyr Lys Arg Lys Arg Thr Lys Gln Glu Pro Ser Ser 
            100                 105                 110         

Gln Gly Ser Gln Ser Ala Leu Gln Thr Tyr Glu Leu Gly Ser Glu Asn 
        115                 120                 125             

Val Lys Val Pro Ile Phe Glu Glu Asp Thr Pro Ser Val Met Glu Ile 
    130                 135                 140                 

Glu Met Glu Glu Leu Asp Lys Trp Met Asn Ser Met Asn Arg Asn Ala 
145                 150                 155                 160 

Asp Phe Glu Cys Leu Pro Thr Leu Lys Glu Glu Lys Glu Ser Asn His 
                165                 170                 175     

Asn Pro Ser Asp Ser Glu Ser 
            180             


<210>  43
<211>  128
<212>  PRT
<213>  Homo sapiens

<400> 43

Glu Thr Leu Asn Ala Asn Ile Asn Ser Thr Asn Phe Ala Pro Asp Glu 
1               5                   10                  15      

Asn Gln Leu Glu Phe Ile Leu Met Val Leu Ile Pro Leu Ile Leu Leu 
            20                  25                  30          

Val Leu Leu Leu Leu Ser Val Val Phe Leu Ala Thr Tyr Tyr Lys Arg 
        35                  40                  45              

Lys Arg Thr Lys Gln Glu Pro Ser Ser Gln Gly Ser Gln Ser Ala Leu 
    50                  55                  60                  

Gln Thr Tyr Glu Leu Gly Ser Glu Asn Val Lys Val Pro Ile Phe Glu 
65                  70                  75                  80  

Glu Asp Thr Pro Ser Val Met Glu Ile Glu Met Glu Glu Leu Asp Lys 
                85                  90                  95      

Trp Met Asn Ser Met Asn Arg Asn Ala Asp Phe Glu Cys Leu Pro Thr 
            100                 105                 110         

Leu Lys Glu Glu Lys Glu Ser Asn His Asn Pro Ser Asp Ser Glu Ser 
        115                 120                 125             


<210>  44
<211>  183
<212>  PRT
<213>  Homo sapiens

<400> 44

Met Gln Ala Pro Arg Ala Ala Leu Val Phe Ala Leu Val Ile Ala Leu 
1               5                   10                  15      

Val Pro Val Gly Arg Gly Asn Tyr Glu Glu Leu Glu Asn Ser Gly Asp 
            20                  25                  30          

Thr Thr Val Glu Ser Glu Arg Pro Asn Lys Val Thr Ile Pro Ser Thr 
        35                  40                  45              

Phe Ala Ala Val Thr Ile Lys Glu Thr Leu Asn Ala Asn Ile Asn Ser 
    50                  55                  60                  

Thr Asn Phe Ala Pro Asp Glu Asn Gln Leu Glu Phe Ile Leu Met Val 
65                  70                  75                  80  

Leu Ile Pro Leu Ile Leu Leu Val Leu Leu Leu Leu Phe Val Val Phe 
                85                  90                  95      

Leu Ala Thr Tyr Tyr Lys Arg Lys Arg Thr Lys Gln Glu Pro Ser Ser 
            100                 105                 110         

Gln Gly Ser Gln Ser Ala Leu Gln Thr Tyr Glu Leu Gly Ser Glu Asn 
        115                 120                 125             

Val Lys Val Pro Ile Phe Glu Glu Asp Thr Pro Ser Val Met Glu Ile 
    130                 135                 140                 

Glu Met Glu Glu Leu Asp Lys Trp Met Asn Ser Met Asn Arg Asn Ala 
145                 150                 155                 160 

Asp Phe Glu Cys Leu Pro Thr Leu Lys Glu Glu Lys Glu Ser Asn His 
                165                 170                 175     

Asn Pro Ser Asp Ser Glu Ser 
            180             


<210>  45
<211>  105
<212>  PRT
<213>  Homo sapiens

<400> 45

Met Val Leu Ile Pro Leu Ile Leu Leu Val Leu Leu Leu Leu Ser Val 
1               5                   10                  15      

Val Phe Leu Ala Thr Tyr Tyr Lys Arg Lys Arg Thr Lys Gln Glu Pro 
            20                  25                  30          

Ser Ser Gln Gly Ser Gln Ser Ala Leu Gln Thr Tyr Glu Leu Gly Ser 
        35                  40                  45              

Glu Asn Val Lys Val Pro Ile Phe Glu Glu Asp Thr Pro Ser Val Met 
    50                  55                  60                  

Glu Ile Glu Met Glu Glu Leu Asp Lys Trp Met Asn Ser Met Asn Arg 
65                  70                  75                  80  

Asn Ala Asp Phe Glu Cys Leu Pro Thr Leu Lys Glu Glu Lys Glu Ser 
                85                  90                  95      

Asn His Asn Pro Ser Asp Ser Glu Ser 
            100                 105 


<210>  46
<211>  144
<212>  PRT
<213>  Homo sapiens

<400> 46

Met Gln Ala Pro Arg Ala Ala Leu Val Phe Ala Leu Val Ile Ala Leu 
1               5                   10                  15      

Val Pro Val Gly Arg Gly Asn Tyr Glu Glu Leu Glu Asn Ser Gly Asp 
            20                  25                  30          

Thr Thr Val Glu Ser Glu Arg Pro Asn Lys Val Thr Ile Pro Ser Thr 
        35                  40                  45              

Phe Ala Ala Val Thr Ile Lys Glu Thr Leu Asn Ala Asn Ile Asn Ser 
    50                  55                  60                  

Thr Asn Phe Ala Pro Asp Glu Asn Gln Leu Glu Phe Ile Leu Met Val 
65                  70                  75                  80  

Leu Ile Pro Leu Ile Leu Leu Val Leu Leu Leu Leu Ser Val Val Phe 
                85                  90                  95      

Leu Ala Thr Tyr Tyr Lys Arg Lys Arg Thr Lys Gln Glu Pro Ser Ser 
            100                 105                 110         

Gln Gly Ser Gln Ser Ala Leu Gln Thr Cys Lys Ile Gln Leu Ser Trp 
        115                 120                 125             

Lys Val Ile Pro Ala Phe Cys Leu Glu Ser Ser His Arg Asn Ala Leu 
    130                 135                 140                 


<210>  47
<211>  21
<212>  PRT
<213>  

<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 47

Thr Val Leu Arg His Val Ala Asn Pro Arg Gly Ala Val Thr Pro Glu 
1               5                   10                  15      

Tyr Thr Val Ala Asn 
            20      


<210>  48
<211>  48
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 48

Leu Ala Val Ser Leu Thr Val Ala Asn Gly Gly Arg Arg Leu Ile Ala 
1               5                   10                  15      

Asp Cys His Pro Gly Leu Leu Asp Pro Leu Val Pro Leu Asp Glu Gly 
            20                  25                  30          

Pro Gly His Thr Asp Cys Pro Phe Asp Pro Thr Arg Ile Tyr Asp Thr 
        35                  40                  45              


<210>  49
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 49

Met Arg Arg Cys Ser Leu Cys Ala Phe Asp Ala Ala Arg Gly Pro Arg 
1               5                   10                  15      

Arg Leu Met Arg 
            20  


<210>  50
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 50

Asp Pro Gly Gly Gly Arg Ala Pro Gly Glu Pro Ser Arg Pro Lys 
1               5                   10                  15  


<210>  51
<211>  57
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 51

Cys Cys Val Ala Ala Leu Thr Leu Arg Gly Val Gly Pro Cys Arg Lys 
1               5                   10                  15      

Asp Gly Leu Gln Gly Gln Leu Glu Glu Met Thr Glu Leu Glu Ser Pro 
            20                  25                  30          

Lys Cys Lys Arg Gln Glu Asn Glu Gln Leu Leu Asp Gln Asn Gln Glu 
        35                  40                  45              

Ile Arg Ala Ser Gln Arg Ser Trp Val 
    50                  55          


<210>  52
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 52

Gln Cys Pro Cys Ser Ala Ala Trp Asn 
1               5                   


<210>  53
<211>  51
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 53

Glu Cys Ala Ala Thr Gly Ser Ala Ala Phe Ala Gln Arg Leu Cys Leu 
1               5                   10                  15      

Gly Arg Asn Arg Ser Cys Ala Ala Glu Leu Pro Leu Val Pro Cys Asn 
            20                  25                  30          

Gln Ala Lys Ala Ser Asp Val Gln Asp Leu Leu Lys Asp Leu Lys Ala 
        35                  40                  45              

Gln Ser Gln 
    50      


<210>  54
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 54

Thr Thr Arg Thr Gln Asn Val Thr Val 
1               5                   


<210>  55
<211>  116
<212>  PRT
<213>  Homo sapiens

<400> 55

Asp Gly Val Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala 
1               5                   10                  15      

Asn Arg Cys His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu 
            20                  25                  30          

Val Ile Ser Ser Ser Thr Lys Asn Ser Pro Ser Thr Arg Val Met Arg 
        35                  40                  45              

Asn Leu Thr Gln Ala Ala Arg Glu Val Asn Cys Pro His Leu Ser Arg 
    50                  55                  60                  

Glu Phe Cys Thr Pro Arg Ile Arg Gly Asn Thr Cys Phe Cys Cys Asp 
65                  70                  75                  80  

Leu Tyr Asn Cys Gly Asn Arg Val Glu Ile Thr Gly Gly Tyr Tyr Glu 
                85                  90                  95      

Tyr Ile Asp Val Ser Ser Cys Gln Asp Ile Ile His Leu Tyr His Leu 
            100                 105                 110         

Leu Trp Ser Ala 
        115     


<210>  56
<211>  92
<212>  PRT
<213>  Homo sapiens

<400> 56

Asp Gly Val Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala 
1               5                   10                  15      

Asn Arg Cys His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu 
            20                  25                  30          

Val Asn Cys Pro His Leu Ser Arg Glu Phe Cys Thr Pro Arg Ile Arg 
        35                  40                  45              

Gly Asn Thr Cys Phe Cys Cys Asp Leu Tyr Asn Cys Gly Asn Arg Val 
    50                  55                  60                  

Glu Ile Thr Gly Gly Tyr Tyr Glu Tyr Ile Asp Val Ser Ser Cys Gln 
65                  70                  75                  80  

Asp Ile Ile His Leu Tyr His Leu Leu Trp Ser Ala 
                85                  90          


<210>  57
<211>  106
<212>  PRT
<213>  Homo sapiens

<400> 57

Gly Gly Phe Lys Asp Met Asn Pro Thr Leu Pro Ala Leu Asn Cys Ser 
1               5                   10                  15      

Val Glu Asn Thr His Pro Thr Val Ser Tyr Tyr Ala His Pro Gln Val 
            20                  25                  30          

Ala Ser Tyr Asn Thr Tyr Tyr His Ser Pro Pro His Leu Pro Pro Tyr 
        35                  40                  45              

Ser Ala Tyr Asp Phe Gln His Ser Gly Val Phe Pro Ser Ser Pro Pro 
    50                  55                  60                  

Ser Gly Leu Ser Asp Glu Pro Gln Ser Ala Ser Pro Ser Pro Ser Tyr 
65                  70                  75                  80  

Met Trp Ser Ser Ser Ala Pro Pro Arg Tyr Ser Pro Pro Tyr Tyr Pro 
                85                  90                  95      

Pro Phe Glu Lys Pro Pro Pro Tyr Ser Pro 
            100                 105     


<210>  58
<211>  132
<212>  PRT
<213>  Homo sapiens

<400> 58

Asp Gly Val Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala 
1               5                   10                  15      

Asn Arg Cys His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu 
            20                  25                  30          

Asn Pro Thr Leu Pro Ala Leu Asn Cys Ser Val Glu Asn Thr His Pro 
        35                  40                  45              

Thr Val Ser Tyr Tyr Ala His Pro Gln Val Ala Ser Tyr Asn Thr Tyr 
    50                  55                  60                  

Tyr His Ser Pro Pro His Leu Pro Pro Tyr Ser Ala Tyr Asp Phe Gln 
65                  70                  75                  80  

His Ser Gly Val Phe Pro Ser Ser Pro Pro Ser Gly Leu Ser Asp Glu 
                85                  90                  95      

Pro Gln Ser Ala Ser Pro Ser Pro Ser Tyr Met Trp Ser Ser Ser Ala 
            100                 105                 110         

Pro Pro Arg Tyr Ser Pro Pro Tyr Tyr Pro Pro Phe Glu Lys Pro Pro 
        115                 120                 125             

Pro Tyr Ser Pro 
    130         


<210>  59
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 59

Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro Gly 
1               5                   10                  15  


<210>  60
<211>  55
<212>  PRT
<213>  Homo sapiens

<400> 60

Met Ser Gly Ala Cys Thr Ser Tyr Val Ser Ala Glu Gln Glu Val Val 
1               5                   10                  15      

Arg Gly Phe Ser Cys Pro Arg Pro Gly Gly Glu Ala Ala Ala Val Phe 
            20                  25                  30          

Cys Cys Gly Phe Arg Asp His Lys Tyr Cys Cys Asp Asp Pro His Ser 
        35                  40                  45              

Phe Phe Pro Tyr Glu His Ser 
    50                  55  


<210>  61
<211>  100
<212>  PRT
<213>  Homo sapiens

<400> 61

Ser Ser Lys Pro His Thr Lys Leu Asp Leu Gly Leu Ser Leu Gln Thr 
1               5                   10                  15      

Ala Gly Pro Glu Glu Val Ser Pro Asp Cys Gln Gly Val Asn Thr Gly 
            20                  25                  30          

Met Ala Ala Glu Val Pro Lys Val Ser Pro Leu Gln Gln Ser Tyr Ser 
        35                  40                  45              

Cys Leu Asn Pro Gln Leu Glu Ser Asn Glu Gly Gln Ala Val Asn Ser 
    50                  55                  60                  

Lys Arg Leu Leu His His Cys Phe Met Ala Thr Val Thr Thr Ser Asp 
65                  70                  75                  80  

Ile Pro Gly Ser Pro Glu Glu Ala Ser Val Pro Asn Pro Asp Leu Cys 
                85                  90                  95      

Gly Pro Val Pro 
            100 


<210>  62
<211>  71
<212>  PRT
<213>  Homo sapiens

<400> 62

Met Ala Ser Leu Trp Pro Ser Ala Leu Thr Phe Asn Thr Asp Ala Asn 
1               5                   10                  15      

Ile Pro Gly Pro Leu Gly Phe Cys Gly Gly Trp Val Arg Leu Cys Ser 
            20                  25                  30          

Leu Ser Ser Leu Thr Pro Pro Cys Gly Arg Arg Leu Val Pro Cys Leu 
        35                  40                  45              

Ser Ala Pro Ala Pro Asn Ala Pro Arg Leu Pro Ala Pro Ala Arg Cys 
    50                  55                  60                  

Ser Ile Gly Ala Leu Ile Gly 
65                  70      


<210>  63
<211>  51
<212>  PRT
<213>  Homo sapiens

<400> 63

Glu Glu Leu Glu Asn Ser Gly Asp Thr Thr Val Glu Ser Glu Arg Pro 
1               5                   10                  15      

Asn Lys Val Thr Ile Pro Ser Thr Phe Ala Ala Val Thr Ile Lys Glu 
            20                  25                  30          

Thr Leu Asn Ala Asn Ile Asn Ser Thr Asn Phe Ala Pro Asp Glu Asn 
        35                  40                  45              

Gln Leu Glu 
    50      


<210>  64
<211>  86
<212>  PRT
<213>  Homo sapiens

<400> 64

Ala Thr Tyr Tyr Lys Arg Lys Arg Thr Lys Gln Glu Pro Ser Ser Gln 
1               5                   10                  15      

Gly Ser Gln Ser Ala Leu Gln Thr Tyr Glu Leu Gly Ser Glu Asn Val 
            20                  25                  30          

Lys Val Pro Ile Phe Glu Glu Asp Thr Pro Ser Val Met Glu Ile Glu 
        35                  40                  45              

Met Glu Glu Leu Asp Lys Trp Met Asn Ser Met Asn Arg Asn Ala Asp 
    50                  55                  60                  

Phe Glu Cys Leu Pro Thr Leu Lys Glu Glu Lys Glu Ser Asn His Asn 
65                  70                  75                  80  

Pro Ser Asp Ser Glu Ser 
                85      


<210>  65
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 65

aatttgtcaa gtcggtgcag c                                               21


<210>  66
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 66

tcaccccttc atttttgcgt                                                 20


<210>  67
<211>  106
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 67

aatttgtcaa gtcggtgcag ctggcaagac ctaaaggatt atatgcgtca ggcaggagaa     60

gtgacttatg cagatgctca caagggacgc aaaaatgaag gggtga                   106


<210>  68
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 68

gctccaggcc ataaggactt c                                               21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 69

cagcttcaaa ctctcccctg c                                               21


<210>  70
<211>  103
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 70

gctccaggcc ataaggactt cattccaaat atgattacag gagcagccca ggcggatgta     60

gctgttttag ttgtagatgc cagcagggga gagtttgaag ctg                      103


<210>  71
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 71

ttccttgcca ggacctagag                                                 20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 72

cataaacctt tcgccttgac                                                 20


<210>  73
<211>  128
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 73

ttccttgcca ggacctagag tttgttcagt tccaccccac aggcatatat ggtgctggtt     60

gtctcattac ggaaggatgt cgtggagagg gaggcattct cattaacagt caaggcgaaa    120

ggtttatg                                                             128


<210>  74
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 74

cagccaggtt atgccaacac                                                 20


<210>  75
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 75

tcaaagcagg cgaacttcat c                                           20


<210>  76
<211>  140
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 76

cagccaggtt atgccaacac tttgagggat gcagctccca aaatgtataa ggaagaaggc     60

ctaaaagcat tctacaaggg ggttgctcct ctctggatga gacagatacc atacaccatg    120

atgaagttcg cctgctttga                                                140


<210>  77
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 77

cggtttgctg cggtaatcat                                                 20


<210>  78
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 78

tttcttgctg ccagtctgga c                                               21


<210>  79
<211>  122
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 79

cggtttgctg cggtaatcat gaggataaga gagccacgaa ccacggcact gattttcagt     60

tctgggaaaa tggtgtgcac aggagccaag agtgaagaac agtccagact ggcagcaaga    120

aa                                                                   122


<210>  80
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 80

atttgggtcg cggttcttg                                                  19


<210>  81
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 81

tgccttgaca ttctcgatgg t                                               21


<210>  82
<211>  133
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 82

atttgggtcg cggttcttgt ttgtggatcg ctgtgatcgt cacttgacaa tgcagatctt     60

cgtgaagact ctgactggta agaccatcac cctcgaggtt gagcccagtg acaccatcga    120

gaatgtcaag gca                                                       133


<210>  83
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 83

tgggaacaag agggcatctg                                                 20


<210>  84
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 84

ccaccactgc atcaaattca tg                                              22


<210>  85
<211>  86
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 85

tgggaacaag agggcatctg ctaaagtttc agattccatt tctgctcagt atccagtagt     60

ggatcatgaa tttgatgcag tggtgg                                          86


<210>  86
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 86

tgacactggc aaaacaatgc a                                               21


<210>  87
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 87

ggtccttttc accagcaagc t                                               21


<210>  88
<211>  94
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 88

tgacactggc aaaacaatgc agactttgct ttccttggtc aggcagtata atccaaagat     60

ggtcaaggtc gcaagcttgc tggtgaaaag gacc                                 94


<210>  89
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 89

gaggccgtca ccaagaacat                                                 20


<210>  90
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 90

ggacagccgg tcagagctc                                                  19


<210>  91
<211>  111
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 91

gaggccgtca ccaagaacat tcacgagtcc tgcatgagcc agataggctg gaaccgcatc     60

atcgtggaga agcccttcgg gagggacctg cagagctctg accggctgtc c             111


<210>  92
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 92

cccctttgac cccacaaga                                                  19


<210>  93
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 93

cagccacaca gcagtaacca g                                               21


<210>  94
<211>  107
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 94

cccctttgac cccacaagaa tctatgatac agccttggct ctctggatcc cttctttgct     60

catgtctgca ggggaggctg ctctatctgg ttactgctgt gtggctg                  107


<210>  95
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 95

ggccaaggcg tcggac                                                     16


<210>  96
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 96

gaaaactaac tggagatagg catcg                                           25


<210>  97
<211>  143
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 97

ggccaaggcg tcggacgtgc aggacctcct gaaggatctg aaggctcagt cgcaggtgtt     60

gggctggatc ttgatagcag ttgttatcat cattcttctg atttttacat ctgtcacccg    120

atgcctatct ccagttagtt ttc                                            143


<210>  98
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 98

tcggacgtgc aggacctc                                                   18


<210>  99
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 99

gagataggca tcgggtgaca g                                               21


<210>  100
<211>  121
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 100

tcggacgtgc aggacctcct gaaggatctg aaggctcagt cgcaggtgtt gggctggatc     60

ttgatagcag ttgttatcat cattcttctg atttttacat ctgtcacccg atgcctatct    120

c                                                                    121


<210>  101
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 101

ctggtggctt ctatcgtgtt tatcag                                          26


<210>  102
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 102

cggttagcgt agagtggttt cag                                             23


<210>  103
<211>  116
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 103

ctggtggctt ctatcgtgtt tatcagcttt ggtgtgattg cggctttttg ttgtgccata     60

gttgacgggg tctttgctgc cagacacatt gatctgaaac cactctacgc taaccg        116


<210>  104
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 104

ccttctagcc aaggatctca gagtg                                           25


<210>  105
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 105

cttgggttgt gatttgattc cttctc                                          26


<210>  106
<211>  209
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 106

ccttctagcc aaggatctca gagtgcttta cagacatatg aactgggaag tgaaaacgtg     60

aaagtcccta tttttgagga agatacaccc tctgttatgg aaattgaaat ggaagagctt    120

gataaatgga tgaacagcat gaatagaaat gccgactttg aatgtttacc taccttgaag    180

gaagagaagg aatcaaatca caacccaag                                      209


<210>  107
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 107

cagcattggc gctctcatag g                                               21


<210>  108
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 108

gtgttcacac cttggcagtc ag                                              22


<210>  109
<211>  183
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 109

cagcattggc gctctcatag gcctgtccgt agcagcagtg gttcttctcg ccttcattgt     60

taccgcctgt gtgctctgct acctgttcat cagctctaag ccccacacaa agttggacct    120

gggcttgagc ttacagacag caggccctga ggaggtttct cctgactgcc aaggtgtgaa    180

cac                                                                  183


<210>  110
<211>  1455
<212>  DNA
<213>  Homo sapiens

<400> 110

atgaggcgct gcagtctctg cgctttcgac gccgcccggg ggcccaggcg gctgatgcgt     60

gtgggcctcg cgctgatctt ggtgggccac gtgaacctgc tgctgggggc cgtgctgcat    120

ggcaccgtcc tgcggcacgt ggccaatccc cgcggcgctg tcacgccgga gtacaccgta    180

gccaatgtca tctctgtcgg ctcggggctg ctgagcgttt ccgtgggact tgtggccctc    240

ctggcgtcca ggaaccttct tcgccctcca ctgcactggg tcctgctggc actagctctg    300

gtgaacctgc tcttgtccgt tgcctgctcc ctgggcctcc ttcttgctgt gtcactcact    360

gtggccaacg gtggccgccg ccttattgct gactgccacc caggactgct ggatcctctg    420

gtaccactgg atgaggggcc gggacatact gactgcccct ttgaccccac aagaatctat    480

gatacagcct tggctctctg gatcccttct ttgctcatgt ctgcagggga ggctgctcta    540

tctggttact gctgtgtggc tgcactcact ctacgtggag ttgggccctg caggaaggac    600

ggacttcagg ggcagctaga ggaaatgaca gagcttgaat ctcctaaatg taaaaggcag    660

gaaaatgagc agctactgga tcaaaatcaa gaaatccggg catcacagag aagttgggtt    720

ggaccggtcg ccaccatggt gagcaagggc gaggagctgt tcaccggggt ggtgcccatc    780

ctggtcgagc tggacggcga cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag    840

ggcgatgcca cctacggcaa gctgaccctg aagttcatct gcaccaccgg caagctgccc    900

gtgccctggc ccaccctcgt gaccaccctg acctacggcg tgcagtgctt cagccgctac    960

cccgaccaca tgaagcagca cgacttcttc aagtccgcca tgcccgaagg ctacgtccag   1020

gagcgcacca tcttcttcaa ggacgacggc aactacaaga cccgcgccga ggtgaagttc   1080

gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc   1140

aacatcctgg ggcacaagct ggagtacaac tacaacagcc acaacgtcta tatcatggcc   1200

gacaagcaga agaacggcat caaggtgaac ttcaagatcc gccacaacat cgaggacggc   1260

agcgtgcagc tcgccgacca ctaccagcag aacaccccca tcggcgacgg ccccgtgctg   1320

ctgcccgaca accactacct gagcacccag tccgccctga gcaaagaccc caacgagaag   1380

cgcgatcaca tggtcctgct ggagttcgtg accgccgccg ggatcactct cggcatggac   1440

gagctgtaca agtaa                                                    1455


<210>  111
<211>  1437
<212>  DNA
<213>  Homo sapiens

<400> 111

atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac     60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac    120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc    180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag    240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc    300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg    360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac    420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac    480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc    540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac    600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc    660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagagg    720

cgctgcagtc tctgcgcttt cgacgccgcc cgggggccca ggcggctgat gcgtgtgggc    780

ctcgcgctga tcttggtggg ccacgtgaac ctgctgctgg gggccgtgct gcatggcacc    840

gtcctgcggc acgtggccaa tccccgcggc gctgtcacgc cggagtacac cgtagccaat    900

gtcatctctg tcggctcggg gctgctgagc gtttccgtgg gacttgtggc cctcctggcg    960

tccaggaacc ttcttcgccc tccactgcac tgggtcctgc tggcactagc tctggtgaac   1020

ctgctcttgt ccgttgcctg ctccctgggc ctccttcttg ctgtgtcact cactgtggcc   1080

aacggtggcc gccgccttat tgctgactgc cacccaggac tgctggatcc tctggtacca   1140

ctggatgagg ggccgggaca tactgactgc ccctttgacc ccacaagaat ctatgataca   1200

gccttggctc tctggatccc ttctttgctc atgtctgcag gggaggctgc tctatctggt   1260

tactgctgtg tggctgcact cactctacgt ggagttgggc cctgcaggaa ggacggactt   1320

caggggcagc tagaggaaat gacagagctt gaatctccta aatgtaaaag gcaggaaaat   1380

gagcagctac tggatcaaaa tcaagaaatc cgggcatcac agagaagttg ggtttag      1437


<210>  112
<211>  723
<212>  DNA
<213>  Homo sapiens

<400> 112

atgaggcgct gcagtctctg cgctttcgac gccgcccggg ggcccaggcg gctgatgcgt     60

gtgggcctcg cgctgatctt ggtgggccac gtgaacctgc tgctgggggc cgtgctgcat    120

ggcaccgtcc tgcggcacgt ggccaatccc cgcggcgctg tcacgccgga gtacaccgta    180

gccaatgtca tctctgtcgg ctcggggctg ctgagcgttt ccgtgggact tgtggccctc    240

ctggcgtcca ggaaccttct tcgccctcca ctgcactggg tcctgctggc actagctctg    300

gtgaacctgc tcttgtccgt tgcctgctcc ctgggcctcc ttcttgctgt gtcactcact    360

gtggccaacg gtggccgccg ccttattgct gactgccacc caggactgct ggatcctctg    420

gtaccactgg atgaggggcc gggacatact gactgcccct ttgaccccac aagaatctat    480

gatacagcct tggctctctg gatcccttct ttgctcatgt ctgcagggga ggctgctcta    540

tctggttact gctgtgtggc tgcactcact ctacgtggag ttgggccctg caggaaggac    600

ggacttcagg ggcagctaga ggaaatgaca gagcttgaat ctcctaaatg taaaaggcag    660

gaaaatgagc agctactgga tcaaaatcaa gaaatccggg catcacagag aagttgggtt    720

tag                                                                  723


<210>  113
<211>  484
<212>  PRT
<213>  Homo sapiens

<400> 113

Met Arg Arg Cys Ser Leu Cys Ala Phe Asp Ala Ala Arg Gly Pro Arg 
1               5                   10                  15      

Arg Leu Met Arg Val Gly Leu Ala Leu Ile Leu Val Gly His Val Asn 
            20                  25                  30          

Leu Leu Leu Gly Ala Val Leu His Gly Thr Val Leu Arg His Val Ala 
        35                  40                  45              

Asn Pro Arg Gly Ala Val Thr Pro Glu Tyr Thr Val Ala Asn Val Ile 
    50                  55                  60                  

Ser Val Gly Ser Gly Leu Leu Ser Val Ser Val Gly Leu Val Ala Leu 
65                  70                  75                  80  

Leu Ala Ser Arg Asn Leu Leu Arg Pro Pro Leu His Trp Val Leu Leu 
                85                  90                  95      

Ala Leu Ala Leu Val Asn Leu Leu Leu Ser Val Ala Cys Ser Leu Gly 
            100                 105                 110         

Leu Leu Leu Ala Val Ser Leu Thr Val Ala Asn Gly Gly Arg Arg Leu 
        115                 120                 125             

Ile Ala Asp Cys His Pro Gly Leu Leu Asp Pro Leu Val Pro Leu Asp 
    130                 135                 140                 

Glu Gly Pro Gly His Thr Asp Cys Pro Phe Asp Pro Thr Arg Ile Tyr 
145                 150                 155                 160 

Asp Thr Ala Leu Ala Leu Trp Ile Pro Ser Leu Leu Met Ser Ala Gly 
                165                 170                 175     

Glu Ala Ala Leu Ser Gly Tyr Cys Cys Val Ala Ala Leu Thr Leu Arg 
            180                 185                 190         

Gly Val Gly Pro Cys Arg Lys Asp Gly Leu Gln Gly Gln Leu Glu Glu 
        195                 200                 205             

Met Thr Glu Leu Glu Ser Pro Lys Cys Lys Arg Gln Glu Asn Glu Gln 
    210                 215                 220                 

Leu Leu Asp Gln Asn Gln Glu Ile Arg Ala Ser Gln Arg Ser Trp Val 
225                 230                 235                 240 

Gly Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly 
                245                 250                 255     

Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys 
            260                 265                 270         

Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
        275                 280                 285             

Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
    290                 295                 300                 

Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr 
305                 310                 315                 320 

Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
                325                 330                 335     

Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
            340                 345                 350         

Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
        355                 360                 365             

Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
    370                 375                 380                 

His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala 
385                 390                 395                 400 

Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn 
                405                 410                 415     

Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
            420                 425                 430         

Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
        435                 440                 445             

Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
    450                 455                 460                 

Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
465                 470                 475                 480 

Glu Leu Tyr Lys 
<210>  114

<211>  478
<212>  PRT
<213>  Homo sapiens

<400> 114

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      

Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          

Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              

Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  

Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  

Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      

Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         

Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             

Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 

Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 

Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     

Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         

Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             

Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 

Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Arg 
225                 230                 235                 240 

Arg Cys Ser Leu Cys Ala Phe Asp Ala Ala Arg Gly Pro Arg Arg Leu 
                245                 250                 255     

Met Arg Val Gly Leu Ala Leu Ile Leu Val Gly His Val Asn Leu Leu 
            260                 265                 270         

Leu Gly Ala Val Leu His Gly Thr Val Leu Arg His Val Ala Asn Pro 
        275                 280                 285             

Arg Gly Ala Val Thr Pro Glu Tyr Thr Val Ala Asn Val Ile Ser Val 
    290                 295                 300                 

Gly Ser Gly Leu Leu Ser Val Ser Val Gly Leu Val Ala Leu Leu Ala 
305                 310                 315                 320 

Ser Arg Asn Leu Leu Arg Pro Pro Leu His Trp Val Leu Leu Ala Leu 
                325                 330                 335     

Ala Leu Val Asn Leu Leu Leu Ser Val Ala Cys Ser Leu Gly Leu Leu 
            340                 345                 350         

Leu Ala Val Ser Leu Thr Val Ala Asn Gly Gly Arg Arg Leu Ile Ala 
        355                 360                 365             

Asp Cys His Pro Gly Leu Leu Asp Pro Leu Val Pro Leu Asp Glu Gly 
    370                 375                 380                 

Pro Gly His Thr Asp Cys Pro Phe Asp Pro Thr Arg Ile Tyr Asp Thr 
385                 390                 395                 400 

Ala Leu Ala Leu Trp Ile Pro Ser Leu Leu Met Ser Ala Gly Glu Ala 
                405                 410                 415     

Ala Leu Ser Gly Tyr Cys Cys Val Ala Ala Leu Thr Leu Arg Gly Val 
            420                 425                 430         

Gly Pro Cys Arg Lys Asp Gly Leu Gln Gly Gln Leu Glu Glu Met Thr 
        435                 440                 445             

Glu Leu Glu Ser Pro Lys Cys Lys Arg Gln Glu Asn Glu Gln Leu Leu 
    450                 455                 460                 

Asp Gln Asn Gln Glu Ile Arg Ala Ser Gln Arg Ser Trp Val 
465                 470                 475             


<210>  115
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 115

Glu Gln Leu Leu Asp Gln Asn Gln Glu Ile Arg Ala Ser Gln Arg Ser 
1               5                   10                  15      


<210>  116
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 116

Leu Asp Glu Gly Pro Gly His Thr Asp Cys Pro Phe Asp Pro Thr Arg 
1               5                   10                  15      


<210>  117
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 117

Glu Lys Phe Arg Ala Val Leu Asp Leu His Val Lys His 
1               5                   10              


<210>  118
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 118

Cys Asn Gln Ala Lys Ala Ser Asp Val Gln Asp Leu Leu Lys Asp 
1               5                   10                  15  


<210>  119
<211>  1002
<212>  DNA
<213>  Homo sapiens

<400> 119

atgcatcagt ccctgactca gcagcggtcc agcgacatgt ccctgcccga ttccatggga     60

gcattcaatc ggaggaaacg aaactccatc tatgtcaccg tgactttgct tattgtgtcc    120

gtgttaattc tcacagtggg ccttgctgca accaccagga cccagaatgt gactgtagga    180

ggttattacc ccggagttat tctcggcttt ggatcgttcc ttggaatcat tggatcaaac    240

cttattgaga acaaaaggca gatgctggtg gcttctatcg tgtttatcag ctttggtgtg    300

attgcggctt tttgttgtgc catagttgac ggggtctttg ctgccagaca cattgatctg    360

aaaccactct acgctaaccg gtgccattat gttcccaaga catcacagaa ggaagctgag    420

gaggttaact gccctcacct cagccgtgaa ttctgcacac ctcgcatccg gggcaacacc    480

tgcttctgct gtgacctcta caactgtggc aaccgggtgg agatcactgg tgggtactac    540

gaatacatcg atgtcagcag ttgccaagat atcatccacc tctaccacct gctctggtct    600

gccaccatcc tcaacattgt tggcctgttc ctgggcatca tcactgccgc tgtccttgga    660

ggctttaagg acatgaaccc aactctccca gcactgaact gttctgttga aaatacccat    720

ccaacagttt cttactatgc tcatccccaa gtggcatcct acaataccta ctaccatagc    780

cctcctcacc tgccaccata ttctgcttat gactttcagc attccggtgt ctttccatcc    840

tcccctccct ctggactttc tgatgagccc cagtctgcct ctccctcacc cagctacatg    900

tggtcctcaa gtgcaccgcc ccgttactct ccaccctact atccaccttt tgaaaagcca    960

ccaccttaca gtcccgacta caaagacgat gacgacaagt aa                      1002


<210>  120
<211>  333
<212>  PRT
<213>  Homo sapiens

<400> 120

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          

Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              

Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  

Gly Val Ile Leu Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ser Asn 
65                  70                  75                  80  

Leu Ile Glu Asn Lys Arg Gln Met Leu Val Ala Ser Ile Val Phe Ile 
                85                  90                  95      

Ser Phe Gly Val Ile Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val 
            100                 105                 110         

Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys 
        115                 120                 125             

His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu Val Asn Cys 
    130                 135                 140                 

Pro His Leu Ser Arg Glu Phe Cys Thr Pro Arg Ile Arg Gly Asn Thr 
145                 150                 155                 160 

Cys Phe Cys Cys Asp Leu Tyr Asn Cys Gly Asn Arg Val Glu Ile Thr 
                165                 170                 175     

Gly Gly Tyr Tyr Glu Tyr Ile Asp Val Ser Ser Cys Gln Asp Ile Ile 
            180                 185                 190         

His Leu Tyr His Leu Leu Trp Ser Ala Thr Ile Leu Asn Ile Val Gly 
        195                 200                 205             

Leu Phe Leu Gly Ile Ile Thr Ala Ala Val Leu Gly Gly Phe Lys Asp 
    210                 215                 220                 

Met Asn Pro Thr Leu Pro Ala Leu Asn Cys Ser Val Glu Asn Thr His 
225                 230                 235                 240 

Pro Thr Val Ser Tyr Tyr Ala His Pro Gln Val Ala Ser Tyr Asn Thr 
                245                 250                 255     

Tyr Tyr His Ser Pro Pro His Leu Pro Pro Tyr Ser Ala Tyr Asp Phe 
            260                 265                 270         

Gln His Ser Gly Val Phe Pro Ser Ser Pro Pro Ser Gly Leu Ser Asp 
        275                 280                 285             

Glu Pro Gln Ser Ala Ser Pro Ser Pro Ser Tyr Met Trp Ser Ser Ser 
    290                 295                 300                 

Ala Pro Pro Arg Tyr Ser Pro Pro Tyr Tyr Pro Pro Phe Glu Lys Pro 
305                 310                 315                 320 

Pro Pro Tyr Ser Pro Asp Tyr Lys Asp Asp Asp Asp Lys 
                325                 330             


<210>  121
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 121

Cys His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu Val 
1               5                   10                  15  


<210>  122
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 122

ctgaaggatc tgaaggctca gtc                                             23


<210>  123
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 123

ggatctgctg ctcctgttcc                                                 20


<210>  124
<211>  163
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 124

ctgaaggatc tgaaggctca gtcgcaggtg ttgggctgga tcttgatagc agttgttatc     60

atcattcttc tgatttttac atctgtcacc cgatgcctat ctccagttag ttttctgcag    120

ctgaaattct ggaaaatcta tttggaacag gagcagcaga tcc                      163


<210>  125
<211>  669
<212>  DNA
<213>  Homo sapiens

<400> 125

gaaggagatc aggcagagga gagaagagtc agtgtgaact aggctggtgg ctctgtccgg     60

tagggagacg gaaagggtgc cgcccatcat agaagtacca gaacttgagc tggactttgc    120

tgatttagct tatggaagag gaaccagaaa tttgtccttg aataatgttt cccgtgttgg    180

gctggatctt gatagcagtt gttatcatca ttcttctgat ttttacatct gtcacccgat    240

gcctatctcc agttagtttt ctgcagctga aattctggaa aatctatttg gaacaggagc    300

agcagatcct taaaagtaaa gccacagagc atgcaactga attggcaaaa gagaatatta    360

aatgtttctt tgagggctcg catccaaaag aatataacac tccaagcatg aaagagtggc    420

agcaaatttc atcactgtat actttcaatc cgaagggcca gtactacagc atgttgcaca    480

aatatgtcaa cagaaaagag aagactcaca gtatcaggtc tactgaagga gatacggtga    540

ttcctgttct tggctttgta gattcatctg gtataaacag cactcctgag ttatgacctt    600

ttgaatgagt agaaaaaaaa attgttttga attattgctt tattaaaaaa taaacattgg    660

tattttttg                                                            669


<210>  126
<211>  101
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 126

aatcattatg ctgaggattt ggaaagggtg tttattcctc atggactaat tatggacagg     60

actgaacgtc ttgctcgaga tgtgatgaag gagatgggag g                        101


<210>  127
<211>  117
<212>  PRT
<213>  Homo sapiens

<400> 127

Leu Ser Pro Val Ser Phe Leu Gln Leu Lys Phe Trp Lys Ile Tyr Leu 
1               5                   10                  15      

Glu Gln Glu Gln Gln Ile Leu Lys Ser Lys Ala Thr Glu His Ala Thr 
            20                  25                  30          

Glu Leu Ala Lys Glu Asn Ile Lys Cys Phe Phe Glu Gly Ser His Pro 
        35                  40                  45              

Lys Glu Tyr Asn Thr Pro Ser Met Lys Glu Trp Gln Gln Ile Ser Ser 
    50                  55                  60                  

Leu Tyr Thr Phe Asn Pro Lys Gly Gln Tyr Tyr Ser Met Leu His Lys 
65                  70                  75                  80  

Tyr Val Asn Arg Lys Glu Lys Thr His Ser Ile Arg Ser Thr Glu Gly 
                85                  90                  95      

Asp Thr Val Ile Pro Val Leu Gly Phe Val Asp Ser Ser Gly Ile Asn 
            100                 105                 110         

Ser Thr Pro Glu Leu 
        115         


<210>  128
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 128

aacatcatgg atcagaacaa cagc                                            24


<210>  129
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 129

atcattggac taaagatagg gattcc                                          26


<210>  130
<211>  101
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 130

aacatcatgg atcagaacaa cagcctgcca ccttacgctc agggcttggc ctcccctcag     60

ggtgccatga ctcccggaat ccctatcttt agtccaatga t                        101


<210>  131
<211>  888
<212>  DNA
<213>  Homo sapiens

<400> 131

gtccgctccg gctcctgccg cgttccagca gccgtcactc ccgccgccgg cccccgccgc     60

ccgccccgcc tgcccctacc cctccgcgcg ggccgggcac ctggccgccg ctcggtcctc    120

ggggccccgc gctgctgtct ctgtctcggc ttctctcggc ccctgggtct cttcgtctct    180

gccgttctca ggctcagctc cgtctcgctc ggtccctcgc ttccccgccg ggctctagcc    240

ggccgtctgg tggcccgagg tggcggcggg ctgggcgcgg ggcgcgatga gcggcgcctg    300

cacgagctac gtgagcgcag agcaggaggt ggtgcgcggc ttcagctgcc cgcggccggg    360

gggcgaggcg gccgctgtct tctgctgcgg cttccgcgac cacaagtact gctgcgacga    420

cccgcacagc ttcttcccct acgagcacag ctacatgtgg tggctcagca ttggcgctct    480

cataggcctg tccgtagcag cagtggttct tctcgccttc attgttaccg cctgtgtgct    540

ctgctacctg ttcatcagct ctaagcccca cacaaagttg gacctgggct tgagcttaca    600

gacagcaggc cctgaggagg tttctcctga ctgccaaggt gtgaacacag gcatggcggc    660

agaagtgcca aaagtgagcc ctctccagca gagttactcc tgcttgaacc cgcagctgga    720

gagcaatgag gggcaggctg tgaactccaa acgcctcctc catcattgct tcatggccac    780

agtgaccacc agtgacattc caggcagccc tgaggaagcc tctgtaccca accctgacct    840

atgtggacca gtcccataaa cattcaataa atgtctccat accatccc                 888


<210>  132
<211>  72
<212>  PRT
<213>  Homo sapiens

<400> 132

Met Ser Gly Ala Cys Thr Ser Tyr Val Ser Ala Glu Gln Glu Val Val 
1               5                   10                  15      

Arg Gly Phe Ser Cys Pro Arg Pro Gly Gly Glu Ala Ala Ala Val Phe 
            20                  25                  30          

Cys Cys Gly Phe Arg Asp His Lys Tyr Cys Cys Asp Asp Pro His Ser 
        35                  40                  45              

Phe Phe Pro Tyr Glu His Ser Tyr Met Trp Trp Leu Arg Asp Gly Val 
    50                  55                  60                  

Ser Pro Cys Cys Pro Gly Trp Ser 
65                  70          


<210>  133
<211>  153
<212>  PRT
<213>  Homo sapiens

<400> 133

Met Ser Gly Ala Cys Thr Ser Tyr Val Ser Ala Glu Gln Glu Val Val 
1               5                   10                  15      

Arg Gly Phe Ser Cys Pro Arg Pro Gly Gly Glu Ala Ala Ala Val Phe 
            20                  25                  30          

Cys Cys Gly Phe Arg Asp His Lys Tyr Cys Cys Asp Asp Pro His Ser 
        35                  40                  45              

Phe Phe Pro Tyr Glu His Ser Tyr Met Trp Trp Leu Ser Ile Gly Ala 
    50                  55                  60                  

Leu Ile Gly Leu Ser Val Ala Ala Val Val Leu Leu Ala Phe Ile Val 
65                  70                  75                  80  

Thr Ala Cys Val Leu Cys Tyr Leu Phe Ile Ser Ser Lys Pro His Thr 
                85                  90                  95      

Lys Leu Asp Leu Gly Leu Ser Leu Gln Thr Ala Gly Pro Val Gln Val 
            100                 105                 110         

Ala Thr Asn Lys Arg Asn Gln Thr Val Leu Thr Leu Lys Gly Leu Thr 
        115                 120                 125             

Trp Arg Thr Arg Gln Ala His Lys Trp Pro Gly Gly Pro Val Val Ala 
    130                 135                 140                 

Leu His Gly Ala Leu Gly Arg Lys Lys 
145                 150             


<210>  134
<211>  134
<212>  PRT
<213>  Homo sapiens

<400> 134

Met Trp Trp Leu Ser Ile Gly Ala Leu Ile Gly Leu Ser Val Ala Ala 
1               5                   10                  15      

Val Val Leu Leu Ala Phe Ile Val Thr Ala Cys Val Leu Cys Tyr Leu 
            20                  25                  30          

Phe Ile Ser Ser Lys Pro His Thr Lys Leu Asp Leu Gly Leu Ser Leu 
        35                  40                  45              

Gln Thr Ala Gly Pro Glu Glu Val Ser Pro Asp Cys Gln Gly Val Asn 
    50                  55                  60                  

Thr Gly Met Ala Ala Glu Val Pro Lys Val Ser Pro Leu Gln Gln Ser 
65                  70                  75                  80  

Tyr Ser Cys Leu Asn Pro Gln Leu Glu Ser Asn Glu Gly Gln Ala Val 
                85                  90                  95      

Asn Ser Lys Arg Leu Leu His His Cys Phe Met Ala Thr Val Thr Thr 
            100                 105                 110         

Ser Asp Ile Pro Gly Ser Pro Glu Glu Ala Ser Val Pro Asn Pro Asp 
        115                 120                 125             

Leu Cys Gly Pro Val Pro 
    130                 


<210>  135
<211>  190
<212>  PRT
<213>  Homo sapiens

<400> 135

Met Ser Gly Ala Cys Thr Ser Tyr Val Ser Ala Glu Gln Glu Val Val 
1               5                   10                  15      

Arg Gly Phe Ser Cys Pro Arg Pro Gly Gly Glu Ala Ala Ala Val Phe 
            20                  25                  30          

Cys Cys Gly Phe Arg Asp His Lys Tyr Cys Cys Asp Asp Pro His Ser 
        35                  40                  45              

Phe Phe Pro Tyr Glu His Ser Tyr Met Trp Trp Leu Ser Ile Gly Ala 
    50                  55                  60                  

Leu Ile Gly Leu Ser Val Ala Ala Val Val Leu Leu Ala Phe Ile Val 
65                  70                  75                  80  

Thr Ala Cys Val Leu Cys Tyr Leu Phe Ile Ser Ser Lys Pro His Thr 
                85                  90                  95      

Lys Leu Asp Leu Gly Leu Ser Leu Gln Thr Ala Gly Pro Glu Glu Val 
            100                 105                 110         

Ser Pro Asp Cys Gln Gly Val Asn Thr Gly Met Ala Ala Glu Val Pro 
        115                 120                 125             

Lys Val Ser Pro Leu Gln Gln Ser Tyr Ser Cys Leu Asn Pro Gln Leu 
    130                 135                 140                 

Glu Ser Asn Glu Gly Gln Ala Val Asn Ser Lys Arg Leu Leu His His 
145                 150                 155                 160 

Cys Phe Met Ala Thr Val Thr Thr Ser Asp Ile Pro Gly Ser Pro Glu 
                165                 170                 175     

Glu Ala Ser Val Pro Asn Pro Asp Leu Cys Gly Pro Val Pro 
            180                 185                 190 


<210>  136
<211>  2405
<212>  DNA
<213>  Homo sapiens

<400> 136

tccggcgtgg tgcgcaggcg cggtatcccc cctcccccgc cagctcgacc ccggtgtggt     60

gcgcaggcgc agtctgcgca gggactggcg ggactgcgcg gcggcaacag cagacatgtc    120

gggggtccgg ggcctgtcgc ggctgctgag cgctcggcgc ctggcgctgg ccaaggcgtg    180

gccaacagtg ttgcaaacag gaacccgagg ttttcacttc actgttgatg ggaacaagag    240

ggcatctgct aaagtttcag attccatttc tgctcagtat ccagtagtgg atcatgaatt    300

tgatgcagtg gtggtaggcg ctggaggggc aggcttgcga gctgcatttg gcctttctga    360

ggcagggttt aatacagcat gtgttaccaa gctgtttcct accaggtcac acactgttgc    420

agcacaggga ggaatcaatg ctgctctggg gaacatggag gaggacaact ggaggtggca    480

tttctacgac accgtgaagg gctccgactg gctgggggac caggatgcca tccactacat    540

gacggagcag gcccccgccg ccgtggtcga gctagaaaat tatggcatgc cgtttagcag    600

aactgaagat gggaagattt atcagcgtgc atttggtgga cagagcctca agtttggaaa    660

gggcgggcag gcccatcggt gctgctgtgt ggctgatcgg actggccact cgctattgca    720

caccttatat ggaaggtctc tgcgatatga taccagctat tttgtggagt attttgcctt    780

ggatctcctg atggagaatg gggagtgccg tggtgtcatc gcactgtgca tagaggacgg    840

gtccatccat cgcataagag caaagaacac tgttgttgcc acaggaggct acgggcgcac    900

ctacttcagc tgcacgtctg cccacaccag cactggcgac ggcacggcca tgatcaccag    960

ggcaggcctt ccttgccagg acctagagtt tgttcagttc caccctacag gcatatatgg   1020

tgctggttgt ctcattacgg aaggatgtcg tggagaggga ggcattctca ttaacagtca   1080

aggcgaaagg tttatggagc gatacgcccc tgtcgcgaag gacctggcgt ctagagatgt   1140

ggtgtctcgg tccatgactc tggagatccg agaaggaaga ggctgtggcc ctgagaaaga   1200

tcacgtctac ctgcagctgc accacctacc tccagagcag ctggccacgc gcctgcctgg   1260

catttcagag acagccatga tcttcgctgg cgtggacgtc acgaaggagc cgatccctgt   1320

cctccccacc gtgcattata acatgggcgg cattcccacc aactacaagg ggcaggtcct   1380

gaggcacgtg aatggccagg atcagattgt gcccggcctg tacgcctgtg gggaggccgc   1440

ctgtgcctcg gtacatggtg ccaaccgcct cggggcaaac tcgctcttgg acctggttgt   1500

ctttggtcgg gcatgtgccc tgagcatcga agagtcatgc aggcctggag ataaagtccc   1560

tccaattaaa ccaaacgctg gggaagaatc tgtcatgaat cttgacaaat tgagatttgc   1620

tgatggaagc ataagaacat cggaactgcg actcagcatg cagaagtcaa tgcaaaatca   1680

tgctgccgtg ttccgtgtgg gaagcgtgtt gcaagaaggt tgtgggaaaa tcagcaagct   1740

ctatggagac ctaaagcacc tgaagacgtt cgaccgggga atggtctgga acacggacct   1800

ggtggagacc ctggagctgc agaacctgat gctgtgtgcg ctgcagacca tctacggagc   1860

agaggcacgg aaggagtcac ggggcgcgca tgccagggaa gactacaagg tgcggattga   1920

tgagtacgat tactccaagc ccatccaggg gcaacagaag aagccctttg aggagcactg   1980

gaggaagcac accctgtcct atgtggacgt tggcactggg aaggtcactc tggaatatag   2040

acccgtgatc gacaaaactt tgaacgaggc tgactgtgcc accgtcccgc cagccattcg   2100

ctcctactga tgagacaaga tgtggtgatg acagaatcag cttttgtaat tatgtataat   2160

agctcatgca tgtgtccatg tcataactgt cttcatacgc ttctgcactc tggggaagaa   2220

ggagtacatt gaagggagat tggcacctag tggctgggag cttgccagga acccagtggc   2280

cagggagcgt ggcacttacc tttgtccctt gcttcattct tgtgagatga taaaactggg   2340

cacagctctt aaataaaata taaatgaaca aactttcttt tatttccaaa aaaaaaaaaa   2400

aaaaa                                                               2405


<210>  137
<211>  1435
<212>  DNA
<213>  Homo sapiens

<400> 137

ggcggggcct gcttctcctc agcttcaggc ggctgcgacg agccctcagg cgaacctctc     60

ggctttcccg cgcggcgccg cctcttgctg cgcctccgcc tcctcctctg ctccgccacc    120

ggcttcctcc tcctgagcag tcagcccgcg cgccggccgg ctccgttatg gcgacccgca    180

gccctggcgt cgtgattagt gatgatgaac caggttatga ccttgattta ttttgcatac    240

ctaatcatta tgctgaggat ttggaaaggg tgtttattcc tcatggacta attatggaca    300

ggactgaacg tcttgctcga gatgtgatga aggagatggg aggccatcac attgtagccc    360

tctgtgtgct caaggggggc tataaattct ttgctgacct gctggattac atcaaagcac    420

tgaatagaaa tagtgataga tccattccta tgactgtaga ttttatcaga ctgaagagct    480

attgtaatga ccagtcaaca ggggacataa aagtaattgg tggagatgat ctctcaactt    540

taactggaaa gaatgtcttg attgtggaag atataattga cactggcaaa acaatgcaga    600

ctttgctttc cttggtcagg cagtataatc caaagatggt caaggtcgca agcttgctgg    660

tgaaaaggac cccacgaagt gttggatata agccagactt tgttggattt gaaattccag    720

acaagtttgt tgtaggatat gcccttgact ataatgaata cttcagggat ttgaatcatg    780

tttgtgtcat tagtgaaact ggaaaagcaa aatacaaagc ctaagatgag agttcaagtt    840

gagtttggaa acatctggag tcctattgac atcgccagta aaattatcaa tgttctagtt    900

ctgtggccat ctgcttagta gagctttttg catgtatctt ctaagaattt tatctgtttt    960

gtactttaga aatgtcagtt gctgcattcc taaactgttt atttgcacta tgagcctata   1020

gactatcagt tccctttggg cggattgttg tttaacttgt aaatgaaaaa attctcttaa   1080

accacagcac tattgagtga aacattgaac tcatatctgt aagaaataaa gagaagatat   1140

attagttttt taattggtat tttaattttt atatatgcag gaaagaatag aagtgattga   1200

atattgttaa ttataccacc gtgtgttaga aaagtaagaa gcagtcaatt ttcacatcaa   1260

agacagcatc taagaagttt tgttctgtcc tggaattatt ttagtagtgt ttcagtaatg   1320

ttgactgtat tttccaactt gttcaaatta ttaccagtga atctttgtca gcagttccct   1380

tttaaatgca aatcaataaa ttcccaaaaa tttaaaaaaa aaaaaaaaaa aaaaa        1435


<210>  138
<211>  2395
<212>  DNA
<213>  Homo sapiens

<400> 138

agaggcaggg gctggcctgg gatgcgcgcg cacctgccct cgccccgccc cgcccgcacg     60

aggggtggtg gccgaggccc cgccccgcac gcctcgcctg aggcgggtcc gctcagccca    120

ggcgcccgcc cccgcccccg ccgattaaat gggccggcgg ggctcagccc ccggaaacgg    180

tcgtacactt cggggctgcg agcgcggagg gcgacgacga cgaagcgcag acagcgtcat    240

ggcagagcag gtggccctga gccggaccca ggtgtgcggg atcctgcggg aagagctttt    300

ccagggcgat gccttccatc agtcggatac acacatattc atcatcatgg gtgcatcggg    360

tgacctggcc aagaagaaga tctaccccac catctggtgg ctgttccggg atggccttct    420

gcccgaaaac accttcatcg tgggctatgc ccgttcccgc ctcacagtgg ctgacatccg    480

caaacagagt gagcccttct tcaaggccac cccagaggag aagctcaagc tggaggactt    540

ctttgcccgc aactcctatg tggctggcca gtacgatgat gcagcctcct accagcgcct    600

caacagccac atgaatgccc tccacctggg gtcacaggcc aaccgcctct tctacctggc    660

cttgcccccg accgtctacg aggccgtcac caagaacatt cacgagtcct gcatgagcca    720

gataggctgg aaccgcatca tcgtggagaa gcccttcggg agggacctgc agagctctga    780

ccggctgtcc aaccacatct cctccctgtt ccgtgaggac cagatctacc gcatcgacca    840

ctacctgggc aaggagatgg tgcagaacct catggtgctg agatttgcca acaggatctt    900

cggccccatc tggaaccggg acaacatcgc ctgcgttatc ctcaccttca aggagccctt    960

tggcactgag ggtcgcgggg gctatttcga tgaatttggg atcatccggg acgtgatgca   1020

gaaccaccta ctgcagatgc tgtgtctggt ggccatggag aagcccgcct ccaccaactc   1080

agatgacgtc cgtgatgaga aggtcaaggt gttgaaatgc atctcagagg tgcaggccaa   1140

caatgtggtc ctgggccagt acgtggggaa ccccgatgga gagggcgagg ccaccaaagg   1200

gtacctggac gaccccacgg tgccccgcgg gtccaccacc gccacttttg cagccgtcgt   1260

cctctatgtg gagaatgaga ggtgggatgg ggtgcccttc atcctgcgct gcggcaaggc   1320

cctgaacgag cgcaaggccg aggtgaggct gcagttccat gatgtggccg gcgacatctt   1380

ccaccagcag tgcaagcgca acgagctggt gatccgcgtg cagcccaacg aggccgtgta   1440

caccaagatg atgaccaaga agccgggcat gttcttcaac cccgaggagt cggagctgga   1500

cctgacctac ggcaacagat acaagaacgt gaagctccct gacgcctacg agcgcctcat   1560

cctggacgtc ttctgcggga gccagatgca cttcgtgcgc agcgacgagc tccgtgaggc   1620

ctggcgtatt ttcaccccac tgctgcacca gattgagctg gagaagccca agcccatccc   1680

ctatatttat ggcagccgag gccccacgga ggcagacgag ctgatgaaga gagtgggttt   1740

ccagtatgag ggcacctaca agtgggtgaa cccccacaag ctctgagccc tgggcaccca   1800

cctccacccc cgccacggcc accctccttc ccgccgcccg accccgagtc gggaggactc   1860

cgggaccatt gacctcagct gcacattcct ggccccgggc tctggccacc ctggcccgcc   1920

cctcgctgct gctactaccc gagcccagct acattcctca gctgccaagc actcgagacc   1980

atcctggccc ctccagaccc tgcctgagcc caggagctga gtcacctcct ccactcactc   2040

cagcccaaca gaaggaagga ggagggcgcc cattcgtctg tcccagagct tattggccac   2100

tgggtctcac tcctgagtgg ggccagggtg ggagggaggg acaaggggga ggaaaggggc   2160

gagcacccac gtgagagaat ctgcctgtgg ccttgcccgc cagcctcagt gccacttgac   2220

attccttgtc accagcaaca tctcgagccc cctggatgtc ccctgtccca ccaactctgc   2280

actccatggc caccccgtgc cacccgtagg cagcctctct gctataagaa aagcagacgc   2340

agcagctggg acccctccca acctcaatgc cctgccatta aatccgcaaa cagcc        2395


<210>  139
<211>  2201
<212>  DNA
<213>  Homo sapiens

<400> 139

cgggatttgg gtcgcggttc ttgtttgtgg atcgctgtga tcgtcacttg acaatgcaga     60

tcttcgtgaa gactctgact ggtaagacca tcaccctcga ggttgagccc agtgacacca    120

tcgagaatgt caaggcaaag atccaagata aggaaggcat ccctcctgac cagcagaggc    180

tgatctttgc tggaaaacag ctggaagatg ggcgcaccct gtctgactac aacatccaga    240

aagagtccac cctgcacctg gtgctccgtc tcagaggtgg gatgcaaatc ttcgtgaaga    300

cactcactgg caagaccatc acccttgagg tggagcccag tgacaccatc gagaacgtca    360

aagcaaagat ccaggacaag gaaggcattc ctcctgacca gcagaggttg atctttgccg    420

gaaagcagct ggaagatggg cgcaccctgt ctgactacaa catccagaaa gagtctaccc    480

tgcacctggt gctccgtctc agaggtggga tgcagatctt cgtgaagacc ctgactggta    540

agaccatcac cctcgaggtg gagcccagtg acaccatcga gaatgtcaag gcaaagatcc    600

aagataagga aggcattcct cctgatcagc agaggttgat ctttgccgga aaacagctgg    660

aagatggtcg taccctgtct gactacaaca tccagaaaga gtccaccttg cacctggtac    720

tccgtctcag aggtgggatg caaatcttcg tgaagacact cactggcaag accatcaccc    780

ttgaggtcga gcccagtgac actatcgaga acgtcaaagc aaagatccaa gacaaggaag    840

gcattcctcc tgaccagcag aggttgatct ttgccggaaa gcagctggaa gatgggcgca    900

ccctgtctga ctacaacatc cagaaagagt ctaccctgca cctggtgctc cgtctcagag    960

gtgggatgca gatcttcgtg aagaccctga ctggtaagac catcaccctc gaagtggagc   1020

cgagtgacac cattgagaat gtcaaggcaa agatccaaga caaggaaggc atccctcctg   1080

accagcagag gttgatcttt gccggaaaac agctggaaga tggtcgtacc ctgtctgact   1140

acaacatcca gaaagagtcc accttgcacc tggtgctccg tctcagaggt gggatgcaga   1200

tcttcgtgaa gaccctgact ggtaagacca tcactctcga ggtggagccg agtgacacca   1260

ttgagaatgt caaggcaaag atccaagaca aggaaggcat ccctcctgat cagcagaggt   1320

tgatctttgc tgggaaacag ctggaagatg gacgcaccct gtctgactac aacatccaga   1380

aagagtccac cctgcacctg gtgctccgtc ttagaggtgg gatgcagatc ttcgtgaaga   1440

ccctgactgg taagaccatc actctcgaag tggagccgag tgacaccatt gagaatgtca   1500

aggcaaagat ccaagacaag gaaggcatcc ctcctgacca gcagaggttg atctttgctg   1560

ggaaacagct ggaagatgga cgcaccctgt ctgactacaa catccagaaa gagtccaccc   1620

tgcacctggt gctccgtctt agaggtggga tgcagatctt cgtgaagacc ctgactggta   1680

agaccatcac tctcgaagtg gagccgagtg acaccattga gaatgtcaag gcaaagatcc   1740

aagacaagga aggcatccct cctgaccagc agaggttgat ctttgctggg aaacagctgg   1800

aagatggacg caccctgtct gactacaaca tccagaaaga gtccaccctg cacctggtgc   1860

tccgtctcag aggtgggatg cagatcttcg tgaagaccct gactggtaag accatcaccc   1920

tcgaggtgga gcccagtgac accatcgaga atgtcaaggc aaagatccaa gataaggaag   1980

gcatccctcc tgatcagcag aggttgatct ttgctgggaa acagctggaa gatggacgca   2040

ccctgtctga ctacaacatc cagaaagagt ccactctgca cttggtcctg cgcttgaggg   2100

ggggtgtcta agtttcccct tttaaggttt caacaaattt cattgcactt tcctttcaat   2160

aaagttgttg cattcccaaa aaaaaaaaaa aaaaaaaaaa a                       2201


<210>  140
<211>  1867
<212>  DNA
<213>  Homo sapiens

<400> 140

ggttcgctgt ggcgggcgcc tgggccgccg gctgtttaac ttcgcttccg ctggcccata     60

gtgatctttg cagtgaccca gcagcatcac tgtttcttgg cgtgtgaaga taacccaagg    120

aattgaggaa gttgctgaga agagtgtgct ggagatgctc taggaaaaaa ttgaatagtg    180

agacgagttc cagcgcaagg gtttctggtt tgccaagaag aaagtgaaca tcatggatca    240

gaacaacagc ctgccacctt acgctcaggg cttggcctcc cctcagggtg ccatgactcc    300

cggaatccct atctttagtc caatgatgcc ttatggcact ggactgaccc cacagcctat    360

tcagaacacc aatagtctgt ctattttgga agagcaacaa aggcagcagc agcaacaaca    420

acagcagcag cagcagcagc agcagcaaca gcaacagcag cagcagcagc agcagcagca    480

gcagcagcag cagcagcagc agcagcagca gcaacaggca gtggcagctg cagccgttca    540

gcagtcaacg tcccagcagg caacacaggg aacctcaggc caggcaccac agctcttcca    600

ctcacagact ctcacaactg cacccttgcc gggcaccact ccactgtatc cctcccccat    660

gactcccatg acccccatca ctcctgccac gccagcttcg gagagttctg ggattgtacc    720

gcagctgcaa aatattgtat ccacagtgaa tcttggttgt aaacttgacc taaagaccat    780

tgcacttcgt gcccgaaacg ccgaatataa tcccaagcgg tttgctgcgg taatcatgag    840

gataagagag ccacgaacca cggcactgat tttcagttct gggaaaatgg tgtgcacagg    900

agccaagagt gaagaacagt ccagactggc agcaagaaaa tatgctagag ttgtacagaa    960

gttgggtttt ccagctaagt tcttggactt caagattcag aatatggtgg ggagctgtga   1020

tgtgaagttt cctataaggt tagaaggcct tgtgctcacc caccaacaat ttagtagtta   1080

tgagccagag ttatttcctg gtttaatcta cagaatgatc aaacccagaa ttgttctcct   1140

tatttttgtt tctggaaaag ttgtattaac aggtgctaaa gtcagagcag aaatttatga   1200

agcatttgaa aacatctacc ctattctaaa gggattcagg aagacgacgt aatggctctc   1260

atgtaccctt gcctccccca cccccttctt tttttttttt taaacaaatc agtttgtttt   1320

ggtaccttta aatggtggtg ttgtgagaag atggatgttg agttgcaggg tgtggcacca   1380

ggtgatgccc ttctgtaagt gcccaccgcg ggatgccggg aaggggcatt atttgtgcac   1440

tgagaacacc gcgcagcgtg actgtgagtt gctcataccg tgctgctatc tgggcagcgc   1500

tgcccattta tttatatgta gattttaaac actgctgttg acaagttggt ttgagggaga   1560

aaactttaag tgttaaagcc acctctataa ttgattggac tttttaattt taatgttttt   1620

ccccatgaac cacagttttt atatttctac cagaaaagta aaaatctttt ttaaaagtgt   1680

tgtttttcta atttataact cctaggggtt atttctgtgc cagacacatt ccacctctcc   1740

agtattgcag gacagaatat atgtgttaat gaaaatgaat ggctgtacat atttttttct   1800

ttcttcagag tactctgtac aataaatgca gtttataaaa gtgttaaaaa aaaaaaaaaa   1860

aaaaaaa                                                             1867


<210>  141
<211>  684
<212>  PRT
<213>  Homo sapiens

<400> 141

Met Ala Arg His Arg Asn Val Arg Gly Tyr Asn Tyr Asp Glu Asp Phe 
1               5                   10                  15      

Glu Asp Asp Asp Leu Tyr Gly Gln Ser Val Glu Asp Asp Tyr Cys Ile 
            20                  25                  30          

Ser Pro Ser Thr Ala Ala Gln Phe Ile Tyr Ser Arg Arg Asp Lys Pro 
        35                  40                  45              

Ser Val Glu Pro Val Glu Glu Tyr Asp Tyr Glu Asp Leu Lys Glu Ser 
    50                  55                  60                  

Ser Asn Ser Val Ser Asn His Gln Leu Ser Gly Phe Asp Gln Ala Arg 
65                  70                  75                  80  

Leu Tyr Ser Cys Leu Asp His Met Arg Glu Val Leu Gly Asp Ala Val 
                85                  90                  95      

Pro Asp Glu Ile Leu Ile Glu Ala Val Leu Lys Asn Lys Phe Asp Val 
            100                 105                 110         

Gln Lys Ala Leu Ser Gly Val Leu Glu Gln Asp Arg Val Gln Ser Leu 
        115                 120                 125             

Lys Asp Lys Asn Glu Ala Thr Val Ser Thr Gly Lys Ile Ala Lys Gly 
    130                 135                 140                 

Lys Pro Val Asp Ser Gln Thr Ser Arg Ser Glu Ser Glu Ile Val Pro 
145                 150                 155                 160 

Lys Val Ala Lys Met Thr Val Ser Gly Lys Lys Gln Thr Met Gly Phe 
                165                 170                 175     

Glu Val Pro Gly Val Ser Ser Glu Glu Asn Gly His Ser Phe His Thr 
            180                 185                 190         

Pro Gln Lys Gly Pro Pro Ile Glu Asp Ala Ile Ala Ser Ser Asp Val 
        195                 200                 205             

Leu Glu Thr Ala Ser Lys Ser Ala Asn Pro Pro His Thr Ile Gln Ala 
    210                 215                 220                 

Ser Glu Glu Gln Ser Ser Thr Pro Ala Pro Val Lys Lys Ser Gly Lys 
225                 230                 235                 240 

Leu Arg Gln Gln Ile Asp Val Lys Ala Glu Leu Glu Lys Arg Gln Gly 
                245                 250                 255     

Gly Lys Gln Leu Leu Asn Leu Val Val Ile Gly His Val Asp Ala Gly 
            260                 265                 270         

Lys Ser Thr Leu Met Gly His Met Leu Tyr Leu Leu Gly Asn Ile Asn 
        275                 280                 285             

Lys Arg Thr Met His Lys Tyr Glu Gln Glu Ser Lys Lys Ala Gly Lys 
    290                 295                 300                 

Ala Ser Phe Ala Tyr Ala Trp Val Leu Asp Glu Thr Gly Glu Glu Arg 
305                 310                 315                 320 

Glu Arg Gly Val Thr Met Asp Val Gly Met Thr Lys Phe Glu Thr Thr 
                325                 330                 335     

Thr Lys Val Ile Thr Leu Met Asp Ala Pro Gly His Lys Asp Phe Ile 
            340                 345                 350         

Pro Asn Met Ile Thr Gly Ala Ala Gln Ala Asp Val Ala Val Leu Val 
        355                 360                 365             

Val Asp Ala Ser Arg Gly Glu Phe Glu Ala Gly Phe Glu Thr Gly Gly 
    370                 375                 380                 

Gln Thr Arg Glu His Gly Leu Leu Val Arg Ser Leu Gly Val Thr Gln 
385                 390                 395                 400 

Leu Ala Val Ala Val Asn Lys Met Asp Gln Val Asn Trp Gln Gln Glu 
                405                 410                 415     

Arg Phe Gln Glu Ile Thr Gly Lys Leu Gly His Phe Leu Lys Gln Ala 
            420                 425                 430         

Gly Phe Lys Glu Ser Asp Val Gly Phe Ile Pro Thr Ser Gly Leu Ser 
        435                 440                 445             

Gly Glu Asn Leu Ile Thr Arg Ser Gln Ser Ser Glu Leu Thr Lys Trp 
    450                 455                 460                 

Tyr Lys Gly Leu Cys Leu Leu Glu Gln Ile Asp Ser Phe Lys Pro Pro 
465                 470                 475                 480 

Gln Arg Ser Ile Asp Lys Pro Phe Arg Leu Cys Val Ser Asp Val Phe 
                485                 490                 495     

Lys Asp Gln Gly Ser Gly Phe Cys Ile Thr Gly Lys Ile Glu Ala Gly 
            500                 505                 510         

Tyr Ile Gln Thr Gly Asp Arg Leu Leu Ala Met Pro Pro Asn Glu Thr 
        515                 520                 525             

Cys Thr Val Lys Gly Ile Thr Leu His Asp Glu Pro Val Asp Trp Ala 
    530                 535                 540                 

Ala Ala Gly Asp His Val Ser Leu Thr Leu Val Gly Met Asp Ile Ile 
545                 550                 555                 560 

Lys Ile Asn Val Gly Cys Ile Phe Cys Gly Pro Lys Val Pro Ile Lys 
                565                 570                 575     

Ala Cys Thr Arg Phe Arg Ala Arg Ile Leu Ile Phe Asn Ile Glu Ile 
            580                 585                 590         

Pro Ile Thr Lys Gly Phe Pro Val Leu Leu His Tyr Gln Thr Val Ser 
        595                 600                 605             

Glu Pro Ala Val Ile Lys Arg Leu Ile Ser Val Leu Asn Lys Ser Thr 
    610                 615                 620                 

Gly Glu Val Thr Lys Lys Lys Pro Lys Phe Leu Thr Lys Gly Gln Asn 
625                 630                 635                 640 

Ala Leu Val Glu Leu Gln Thr Gln Arg Pro Ile Ala Leu Glu Leu Tyr 
                645                 650                 655     

Lys Asp Phe Lys Glu Leu Gly Arg Phe Met Leu Arg Tyr Gly Gly Ser 
            660                 665                 670         

Thr Ile Ala Ala Gly Val Val Thr Glu Ile Lys Glu 
        675                 680                 


<210>  142
<211>  664
<212>  PRT
<213>  Homo sapiens

<400> 142

Met Ser Gly Val Arg Gly Leu Ser Arg Leu Leu Ser Ala Arg Arg Leu 
1               5                   10                  15      

Ala Leu Ala Lys Ala Trp Pro Thr Val Leu Gln Thr Gly Thr Arg Gly 
            20                  25                  30          

Phe His Phe Thr Val Asp Gly Asn Lys Arg Ala Ser Ala Lys Val Ser 
        35                  40                  45              

Asp Ser Ile Ser Ala Gln Tyr Pro Val Val Asp His Glu Phe Asp Ala 
    50                  55                  60                  

Val Val Val Gly Ala Gly Gly Ala Gly Leu Arg Ala Ala Phe Gly Leu 
65                  70                  75                  80  

Ser Glu Ala Gly Phe Asn Thr Ala Cys Val Thr Lys Leu Phe Pro Thr 
                85                  90                  95      

Arg Ser His Thr Val Ala Ala Gln Gly Gly Ile Asn Ala Ala Leu Gly 
            100                 105                 110         

Asn Met Glu Glu Asp Asn Trp Arg Trp His Phe Tyr Asp Thr Val Lys 
        115                 120                 125             

Gly Ser Asp Trp Leu Gly Asp Gln Asp Ala Ile His Tyr Met Thr Glu 
    130                 135                 140                 

Gln Ala Pro Ala Ala Val Val Glu Leu Glu Asn Tyr Gly Met Pro Phe 
145                 150                 155                 160 

Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe Gly Gly Gln 
                165                 170                 175     

Ser Leu Lys Phe Gly Lys Gly Gly Gln Ala His Arg Cys Cys Cys Val 
            180                 185                 190         

Ala Asp Arg Thr Gly His Ser Leu Leu His Thr Leu Tyr Gly Arg Ser 
        195                 200                 205             

Leu Arg Tyr Asp Thr Ser Tyr Phe Val Glu Tyr Phe Ala Leu Asp Leu 
    210                 215                 220                 

Leu Met Glu Asn Gly Glu Cys Arg Gly Val Ile Ala Leu Cys Ile Glu 
225                 230                 235                 240 

Asp Gly Ser Ile His Arg Ile Arg Ala Lys Asn Thr Val Val Ala Thr 
                245                 250                 255     

Gly Gly Tyr Gly Arg Thr Tyr Phe Ser Cys Thr Ser Ala His Thr Ser 
            260                 265                 270         

Thr Gly Asp Gly Thr Ala Met Ile Thr Arg Ala Gly Leu Pro Cys Gln 
        275                 280                 285             

Asp Leu Glu Phe Val Gln Phe His Pro Thr Gly Ile Tyr Gly Ala Gly 
    290                 295                 300                 

Cys Leu Ile Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile Leu Ile Asn 
305                 310                 315                 320 

Ser Gln Gly Glu Arg Phe Met Glu Arg Tyr Ala Pro Val Ala Lys Asp 
                325                 330                 335     

Leu Ala Ser Arg Asp Val Val Ser Arg Ser Met Thr Leu Glu Ile Arg 
            340                 345                 350         

Glu Gly Arg Gly Cys Gly Pro Glu Lys Asp His Val Tyr Leu Gln Leu 
        355                 360                 365             

His His Leu Pro Pro Glu Gln Leu Ala Thr Arg Leu Pro Gly Ile Ser 
    370                 375                 380                 

Glu Thr Ala Met Ile Phe Ala Gly Val Asp Val Thr Lys Glu Pro Ile 
385                 390                 395                 400 

Pro Val Leu Pro Thr Val His Tyr Asn Met Gly Gly Ile Pro Thr Asn 
                405                 410                 415     

Tyr Lys Gly Gln Val Leu Arg His Val Asn Gly Gln Asp Gln Ile Val 
            420                 425                 430         

Pro Gly Leu Tyr Ala Cys Gly Glu Ala Ala Cys Ala Ser Val His Gly 
        435                 440                 445             

Ala Asn Arg Leu Gly Ala Asn Ser Leu Leu Asp Leu Val Val Phe Gly 
    450                 455                 460                 

Arg Ala Cys Ala Leu Ser Ile Glu Glu Ser Cys Arg Pro Gly Asp Lys 
465                 470                 475                 480 

Val Pro Pro Ile Lys Pro Asn Ala Gly Glu Glu Ser Val Met Asn Leu 
                485                 490                 495     

Asp Lys Leu Arg Phe Ala Asp Gly Ser Ile Arg Thr Ser Glu Leu Arg 
            500                 505                 510         

Leu Ser Met Gln Lys Ser Met Gln Asn His Ala Ala Val Phe Arg Val 
        515                 520                 525             

Gly Ser Val Leu Gln Glu Gly Cys Gly Lys Ile Ser Lys Leu Tyr Gly 
    530                 535                 540                 

Asp Leu Lys His Leu Lys Thr Phe Asp Arg Gly Met Val Trp Asn Thr 
545                 550                 555                 560 

Asp Leu Val Glu Thr Leu Glu Leu Gln Asn Leu Met Leu Cys Ala Leu 
                565                 570                 575     

Gln Thr Ile Tyr Gly Ala Glu Ala Arg Lys Glu Ser Arg Gly Ala His 
            580                 585                 590         

Ala Arg Glu Asp Tyr Lys Val Arg Ile Asp Glu Tyr Asp Tyr Ser Lys 
        595                 600                 605             

Pro Ile Gln Gly Gln Gln Lys Lys Pro Phe Glu Glu His Trp Arg Lys 
    610                 615                 620                 

His Thr Leu Ser Tyr Val Asp Val Gly Thr Gly Lys Val Thr Leu Glu 
625                 630                 635                 640 

Tyr Arg Pro Val Ile Asp Lys Thr Leu Asn Glu Ala Asp Cys Ala Thr 
                645                 650                 655     

Val Pro Pro Ala Ile Arg Ser Tyr 
            660                 


<210>  143
<211>  494
<212>  PRT
<213>  Homo sapiens

<400> 143

Met Pro Arg Val Tyr Ile Gly Arg Leu Ser Tyr Gln Ala Arg Glu Arg 
1               5                   10                  15      

Asp Val Glu Arg Phe Phe Lys Gly Tyr Gly Lys Ile Leu Glu Val Asp 
            20                  25                  30          

Leu Lys Asn Gly Tyr Gly Phe Val Glu Phe Asp Asp Leu Arg Asp Ala 
        35                  40                  45              

Asp Asp Ala Val Tyr Glu Leu Asn Gly Lys Asp Leu Cys Gly Glu Arg 
    50                  55                  60                  

Val Ile Val Glu His Ala Arg Gly Pro Arg Arg Asp Gly Ser Tyr Gly 
65                  70                  75                  80  

Ser Gly Arg Ser Gly Tyr Gly Tyr Arg Arg Ser Gly Arg Asp Lys Tyr 
                85                  90                  95      

Gly Pro Pro Thr Arg Thr Glu Tyr Arg Leu Ile Val Glu Asn Leu Ser 
            100                 105                 110         

Ser Arg Cys Ser Trp Gln Asp Leu Lys Asp Tyr Met Arg Gln Ala Gly 
        115                 120                 125             

Glu Val Thr Tyr Ala Asp Ala His Lys Gly Arg Lys Asn Glu Gly Val 
    130                 135                 140                 

Ile Glu Phe Val Ser Tyr Ser Asp Met Lys Arg Ala Leu Glu Lys Leu 
145                 150                 155                 160 

Asp Gly Thr Glu Val Asn Gly Arg Lys Ile Arg Leu Val Glu Asp Lys 
                165                 170                 175     

Pro Gly Ser Arg Arg Arg Arg Ser Tyr Ser Arg Ser Arg Ser His Ser 
            180                 185                 190         

Arg Ser Arg Ser Arg Ser Arg His Ser Arg Lys Ser Arg Ser Arg Ser 
        195                 200                 205             

Gly Ser Ser Lys Ser Ser His Ser Lys Ser Arg Ser Arg Ser Arg Ser 
    210                 215                 220                 

Gly Ser Arg Ser Arg Ser Lys Ser Arg Ser Arg Ser Gln Ser Arg Ser 
225                 230                 235                 240 

Arg Ser Lys Lys Glu Lys Ser Arg Ser Pro Ser Lys Glu Lys Ser Arg 
                245                 250                 255     

Ser Arg Ser His Ser Ala Gly Lys Ser Arg Ser Lys Ser Lys Asp Gln 
            260                 265                 270         

Ala Glu Glu Lys Ile Gln Asn Asn Asp Asn Val Gly Lys Pro Lys Ser 
        275                 280                 285             

Arg Ser Pro Ser Arg His Lys Ser Lys Ser Lys Ser Arg Ser Arg Ser 
    290                 295                 300                 

Gln Glu Arg Arg Val Glu Glu Glu Lys Arg Gly Ser Val Ser Arg Gly 
305                 310                 315                 320 

Arg Ser Gln Glu Lys Ser Leu Arg Gln Ser Arg Ser Arg Ser Arg Ser 
                325                 330                 335     

Lys Gly Gly Ser Arg Ser Arg Ser Arg Ser Arg Ser Lys Ser Lys Asp 
            340                 345                 350         

Lys Arg Lys Gly Arg Lys Arg Ser Arg Glu Glu Ser Arg Ser Arg Ser 
        355                 360                 365             

Arg Ser Arg Ser Lys Ser Glu Arg Ser Arg Lys Arg Gly Ser Lys Arg 
    370                 375                 380                 

Asp Ser Lys Ala Gly Ser Ser Lys Lys Lys Lys Lys Glu Asp Thr Asp 
385                 390                 395                 400 

Arg Ser Gln Ser Arg Ser Pro Ser Arg Ser Val Ser Lys Glu Arg Glu 
                405                 410                 415     

His Ala Lys Ser Glu Ser Ser Gln Arg Glu Gly Arg Gly Glu Ser Glu 
            420                 425                 430         

Asn Ala Gly Thr Asn Gln Glu Thr Arg Ser Arg Ser Arg Ser Asn Ser 
        435                 440                 445             

Lys Ser Lys Pro Asn Leu Pro Ser Glu Ser Arg Ser Arg Ser Lys Ser 
    450                 455                 460                 

Ala Ser Lys Thr Arg Ser Arg Ser Lys Ser Arg Ser Arg Ser Ala Ser 
465                 470                 475                 480 

Arg Ser Pro Ser Arg Ser Arg Ser Arg Ser His Ser Arg Ser 
                485                 490                 


<210>  144
<211>  376
<212>  PRT
<213>  Homo sapiens

<400> 144

Thr Phe Pro Arg Glu Trp Leu Cys Asp Arg His Leu Arg Glu Lys Met 
1               5                   10                  15      

Phe Ser Ser Val Ala His Leu Ala Arg Ala Asn Pro Phe Asn Thr Pro 
            20                  25                  30          

His Leu Gln Leu Val His Asp Gly Leu Gly Asp Leu Arg Ser Ser Ser 
        35                  40                  45              

Pro Gly Pro Thr Gly Gln Pro Arg Arg Pro Arg Asn Leu Ala Ala Ala 
    50                  55                  60                  

Ala Val Glu Glu Tyr Ser Cys Glu Phe Gly Ser Ala Lys Tyr Tyr Ala 
65                  70                  75                  80  

Leu Cys Gly Phe Gly Gly Val Leu Ser Cys Gly Leu Thr His Thr Ala 
                85                  90                  95      

Val Val Pro Leu Asp Leu Val Lys Cys Arg Met Gln Val Asp Pro Gln 
            100                 105                 110         

Lys Tyr Lys Gly Ile Phe Asn Gly Phe Ser Val Thr Leu Lys Glu Asp 
        115                 120                 125             

Gly Val Arg Gly Leu Ala Lys Gly Trp Ala Pro Thr Phe Leu Gly Tyr 
    130                 135                 140                 

Ser Met Gln Gly Leu Cys Lys Phe Gly Phe Tyr Glu Val Phe Lys Val 
145                 150                 155                 160 

Leu Tyr Ser Asn Met Leu Gly Glu Glu Asn Thr Tyr Leu Trp Arg Thr 
                165                 170                 175     

Ser Leu Tyr Leu Ala Ala Ser Ala Ser Ala Glu Phe Phe Ala Asp Ile 
            180                 185                 190         

Ala Leu Ala Pro Met Glu Ala Ala Lys Val Arg Ile Gln Thr Gln Pro 
        195                 200                 205             

Gly Tyr Ala Asn Thr Leu Arg Asp Ala Ala Pro Lys Met Tyr Lys Glu 
    210                 215                 220                 

Glu Gly Leu Lys Ala Phe Tyr Lys Gly Val Ala Pro Leu Trp Met Arg 
225                 230                 235                 240 

Gln Ile Pro Tyr Thr Met Met Lys Phe Ala Cys Phe Glu Arg Thr Val 
                245                 250                 255     

Glu Ala Leu Tyr Lys Phe Val Val Pro Lys Pro Arg Ser Glu Cys Ser 
            260                 265                 270         

Lys Pro Glu Gln Leu Val Val Thr Phe Val Ala Gly Tyr Ile Ala Gly 
        275                 280                 285             

Val Phe Cys Ala Ile Val Ser His Pro Ala Asp Ser Val Val Ser Val 
    290                 295                 300                 

Leu Asn Lys Glu Lys Gly Ser Ser Ala Ser Leu Val Leu Lys Arg Leu 
305                 310                 315                 320 

Gly Phe Lys Gly Val Trp Lys Gly Leu Phe Ala Arg Ile Ile Met Ile 
                325                 330                 335     

Gly Thr Leu Thr Ala Leu Gln Trp Phe Ile Tyr Asp Ser Val Lys Val 
            340                 345                 350         

Tyr Phe Arg Leu Pro Arg Pro Pro Pro Pro Glu Met Pro Glu Ser Leu 
        355                 360                 365             

Lys Lys Lys Leu Gly Leu Thr Gln 
    370                 375     


<210>  145
<211>  339
<212>  PRT
<213>  Homo sapiens

<400> 145

Met Asp Gln Asn Asn Ser Leu Pro Pro Tyr Ala Gln Gly Leu Ala Ser 
1               5                   10                  15      

Pro Gln Gly Ala Met Thr Pro Gly Ile Pro Ile Phe Ser Pro Met Met 
            20                  25                  30          

Pro Tyr Gly Thr Gly Leu Thr Pro Gln Pro Ile Gln Asn Thr Asn Ser 
        35                  40                  45              

Leu Ser Ile Leu Glu Glu Gln Gln Arg Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  

Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  

Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala 
                85                  90                  95      

Val Ala Ala Ala Ala Val Gln Gln Ser Thr Ser Gln Gln Ala Thr Gln 
            100                 105                 110         

Gly Thr Ser Gly Gln Ala Pro Gln Leu Phe His Ser Gln Thr Leu Thr 
        115                 120                 125             

Thr Ala Pro Leu Pro Gly Thr Thr Pro Leu Tyr Pro Ser Pro Met Thr 
    130                 135                 140                 

Pro Met Thr Pro Ile Thr Pro Ala Thr Pro Ala Ser Glu Ser Ser Gly 
145                 150                 155                 160 

Ile Val Pro Gln Leu Gln Asn Ile Val Ser Thr Val Asn Leu Gly Cys 
                165                 170                 175     

Lys Leu Asp Leu Lys Thr Ile Ala Leu Arg Ala Arg Asn Ala Glu Tyr 
            180                 185                 190         

Asn Pro Lys Arg Phe Ala Ala Val Ile Met Arg Ile Arg Glu Pro Arg 
        195                 200                 205             

Thr Thr Ala Leu Ile Phe Ser Ser Gly Lys Met Val Cys Thr Gly Ala 
    210                 215                 220                 

Lys Ser Glu Glu Gln Ser Arg Leu Ala Ala Arg Lys Tyr Ala Arg Val 
225                 230                 235                 240 

Val Gln Lys Leu Gly Phe Pro Ala Lys Phe Leu Asp Phe Lys Ile Gln 
                245                 250                 255     

Asn Met Val Gly Ser Cys Asp Val Lys Phe Pro Ile Arg Leu Glu Gly 
            260                 265                 270         

Leu Val Leu Thr His Gln Gln Phe Ser Ser Tyr Glu Pro Glu Leu Phe 
        275                 280                 285             

Pro Gly Leu Ile Tyr Arg Met Ile Lys Pro Arg Ile Val Leu Leu Ile 
    290                 295                 300                 

Phe Val Ser Gly Lys Val Val Leu Thr Gly Ala Lys Val Arg Ala Glu 
305                 310                 315                 320 

Ile Tyr Glu Ala Phe Glu Asn Ile Tyr Pro Ile Leu Lys Gly Phe Arg 
                325                 330                 335     

Lys Thr Thr 
<210>  146

<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 146

Val Ser Ala Ala Gly Asp Pro Gly Gly Gly Arg Ala Pro Gly Glu Pro 
1               5                   10                  15      

Ser Arg Pro Lys Ala Leu Cys Leu Pro Gln 
            20                  25      


<210>  147
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 147

Val Arg Lys Ala Asn Arg Lys Gly Ser Phe His Arg Asp Trp Leu Cys 
1               5                   10                  15      


<210>  148
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 148

Val Val Ala Gly Cys Asp Ala Arg Val Lys Gln Lys Ala Trp Gln Pro 
1               5                   10                  15      

Arg Phe Pro Gly Ile Lys Val Lys Ala Leu 
            20                  25      


<210>  149
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 149

Arg Trp Gly Arg Leu Gly Gly Ala Glu Arg Pro Ser Phe Leu Arg Ala 
1               5                   10                  15      

Ala Gly 
<210>  150

<211>  56
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 150

Met Ser Gly Ala Cys Thr Ser Tyr Val Ser Ala Glu Gln Glu Val Val 
1               5                   10                  15      

Arg Gly Phe Ser Cys Pro Arg Pro Gly Gly Glu Ala Ala Ala Val Phe 
            20                  25                  30          

Cys Cys Gly Phe Arg Asp His Lys Tyr Cys Cys Asp Asp Pro His Ser 
        35                  40                  45              

Phe Phe Pro Tyr Glu His Ser Tyr 
    50                  55      


<210>  151
<211>  81
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 151

Glu Glu Val Ser Pro Asp Cys Gln Gly Val Asn Thr Gly Met Ala Ala 
1               5                   10                  15      

Glu Val Pro Lys Val Ser Pro Leu Gln Gln Ser Tyr Ser Cys Leu Asn 
            20                  25                  30          

Pro Gln Leu Glu Ser Asn Glu Gly Gln Ala Val Asn Ser Lys Arg Leu 
        35                  40                  45              

Leu His His Cys Phe Met Ala Thr Val Thr Thr Ser Asp Ile Pro Gly 
    50                  55                  60                  

Ser Pro Glu Glu Ala Ser Val Pro Asn Pro Asp Leu Cys Gly Pro Val 
65                  70                  75                  80  

Pro 
<210>  152

<211>  130
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 152

Ser Ile Gly Ala Leu Ile Gly Leu Ser Val Ala Ala Val Val Leu Leu 
1               5                   10                  15      

Ala Phe Ile Val Thr Ala Cys Val Leu Cys Tyr Leu Phe Ile Ser Ser 
            20                  25                  30          

Lys Pro His Thr Lys Leu Asp Leu Gly Leu Ser Leu Gln Thr Ala Gly 
        35                  40                  45              

Pro Glu Glu Val Ser Pro Asp Cys Gln Gly Val Asn Thr Gly Met Ala 
    50                  55                  60                  

Ala Glu Val Pro Lys Val Ser Pro Leu Gln Gln Ser Tyr Ser Cys Leu 
65                  70                  75                  80  

Asn Pro Gln Leu Glu Ser Asn Glu Gly Gln Ala Val Asn Ser Lys Arg 
                85                  90                  95      

Leu Leu His His Cys Phe Met Ala Thr Val Thr Thr Ser Asp Ile Pro 
            100                 105                 110         

Gly Ser Pro Glu Glu Ala Ser Val Pro Asn Pro Asp Leu Cys Gly Pro 
        115                 120                 125             

Val Pro 
    130 


<210>  153
<211>  64
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 153

Met Ala Ser Leu Trp Pro Ser Ala Leu Thr Phe Asn Thr Asp Ala Asn 
1               5                   10                  15      

Ile Pro Gly Pro Leu Gly Phe Cys Gly Gly Trp Val Arg Leu Cys Ser 
            20                  25                  30          

Leu Ser Ser Leu Thr Pro Pro Cys Gly Arg Arg Leu Val Pro Cys Leu 
        35                  40                  45              

Ser Ala Pro Ala Pro Asn Ala Pro Arg Leu Pro Ala Pro Ala Arg Cys 
    50                  55                  60                  


<210>  154
<211>  81
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 154

Glu Glu Val Ser Pro Asp Cys Gln Gly Val Asn Thr Gly Met Ala Ala 
1               5                   10                  15      

Glu Val Pro Lys Val Ser Pro Leu Gln Gln Ser Tyr Ser Cys Leu Asn 
            20                  25                  30          

Pro Gln Leu Glu Ser Asn Glu Gly Gln Ala Val Asn Ser Lys Arg Leu 
        35                  40                  45              

Leu His His Cys Phe Met Ala Thr Val Thr Thr Ser Asp Ile Pro Gly 
    50                  55                  60                  

Ser Pro Glu Glu Ala Ser Val Pro Asn Pro Asp Leu Cys Gly Pro Val 
65                  70                  75                  80  

Pro 
<210>  155

<211>  165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 155

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          

Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              

Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  

Gly Val Ile Leu Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ser Asn 
65                  70                  75                  80  

Leu Ile Glu Asn Lys Arg Gln Met Leu Val Ala Ser Ile Val Phe Ile 
                85                  90                  95      

Ser Phe Gly Val Ile Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val 
            100                 105                 110         

Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys 
        115                 120                 125             

His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu Val Ile Ser 
    130                 135                 140                 

Ser Ser Thr Lys Asn Ser Pro Ser Thr Arg Val Met Arg Asn Leu Thr 
145                 150                 155                 160 

Gln Ala Ala Arg Glu 
                165 


<210>  156
<211>  141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 156

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          

Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              

Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  

Gly Val Ile Leu Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ser Asn 
65                  70                  75                  80  

Leu Ile Glu Asn Lys Arg Gln Met Leu Val Ala Ser Ile Val Phe Ile 
                85                  90                  95      

Ser Phe Gly Val Ile Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val 
            100                 105                 110         

Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys 
        115                 120                 125             

His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu 
    130                 135                 140     


<210>  157
<211>  78
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 157

Met Leu Val Ala Ser Ile Val Phe Ile Ser Phe Gly Val Ile Ala Ala 
1               5                   10                  15      

Phe Cys Cys Ala Ile Val Asp Gly Val Phe Ala Ala Arg His Ile Asp 
            20                  25                  30          

Leu Lys Pro Leu Tyr Ala Asn Arg Cys His Tyr Val Pro Lys Thr Ser 
        35                  40                  45              

Gln Lys Glu Ala Glu Glu Val Ile Ser Ser Ser Thr Lys Asn Ser Pro 
    50                  55                  60                  

Ser Thr Arg Val Met Arg Asn Leu Thr Gln Ala Ala Arg Glu 
65                  70                  75              


<210>  158
<211>  141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 158

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          

Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              

Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  

Gly Val Ile Leu Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ser Asn 
65                  70                  75                  80  

Leu Ile Glu Asn Lys Arg Gln Met Leu Val Ala Ser Ile Val Phe Ile 
                85                  90                  95      

Ser Phe Gly Val Ile Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val 
            100                 105                 110         

Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys 
        115                 120                 125             

His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu 
    130                 135                 140     


<210>  159
<211>  67
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 159

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          

Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              

Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  

Gly Val Ile 
65                             


<210>  160
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 160

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          

Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              

Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  

Gly Val Ile Leu Val Ala Ser Ile Val Phe Ile Ser Phe Gly Val Ile 
65                  70                  75                  80  

Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val Phe Ala Ala Arg His 
                85                  90                  95      

Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys His Tyr Val Pro Lys 
            100                 105                 110         

Thr Ser Gln Lys Glu Ala Glu Glu 
        115                 120 


<210>  161
<211>  55
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 161

Met Gln Ala Pro Arg Ala Ala Leu Val Phe Ala Leu Val Ile Ala Leu 
1               5                   10                  15      

Val Pro Val Gly Arg Gly Asn Tyr Glu Glu Leu Glu Asn Ser Gly Asp 
            20                  25                  30          

Thr Thr Val Glu Ser Glu Arg Pro Asn Lys Val Thr Ile Pro Ser Thr 
        35                  40                  45              

Phe Ala Ala Val Thr Ile Lys 
    50                  55  


<210>  162
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 162

Cys Lys Ile Gln Leu Ser Trp Lys Val Ile Pro Ala Phe Cys Leu Glu 
1               5                   10                  15      

Ser Ser His Arg Asn Ala Leu 
            20              


<210>  163
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 163

ctagctagcc accatgaggc gctgcagtct ctg                                  33


<210>  164
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 164

cgcgaccggt ccaacccaac ttctctgtga tg                                   32


<210>  165
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 165

cgattgtaca agaggcgctg cagtctctgc gctt                                 34


<210>  166
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 166

gcgcgcggcc gcctaaaccc aacttctctg t                                    31


<210>  167
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 167

ctagctagcc accatgcatc agtccctgac tc                                   32


<210>  168
<211>  75
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 168

ataagaatgc ggccgctcat tacttgtcgt catcgtcttt gtagtcggga ctgtaaggtg     60

gtggcttttc aaaag                                                      75


<210>  169
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 169

agagcccagc aggccaaag                                                  19


<210>  170
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 170

agcaggaccc agtgcagtg                                                  19


<210>  171
<211>  111
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 171

agagcccagc aggccaaagg ctttgtgtct tccacagagc gtttccgtgg gacttgtggc     60

cctcctggcg tccaggaacc ttcttcgccc tccactgcac tgggtcctgc t             111


<210>  172
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 172

ctagctagcc accatggaga agtttcgggc                                      30


<210>  173
<211>  68
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 173

cgcaccggtt cattacttgt cgtcatcgtc tttgtagtct aactcaggag tgctgtttat     60

accagatg                                                              68


<210>  174
<211>  972
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 174

atggagaagt ttcgggcggt gctggacctg cacgtcaagc accacagcgc cttgggctac     60

ggcctggtga ccctgctgac ggcgggcggg gagcgcatct tctccgccgt ggcattccag    120

tgcccgtgca gcgccgcctg gaacctgccc tacggcctgg tcttcttgct ggtgccggcg    180

ctcgcgctct tcctcctggg ctacgtgctg agcgcacgca cgtggcgcct gctcaccgga    240

tgctgctcca gcgcccgcgc gagttgcgga tcggcgctgc gcggctccct ggtgtgcgcg    300

caaatcagcg cggccgccgc gctcgcgccc ctcacctggg tggccgtggc gctgctcggg    360

ggcgcctttt acgagtgcgc ggccaccggg agcgcggcct tcgcgcagcg cctgtgcctc    420

ggccgcaacc gcagctgcgc cgcggagctg ccgctggtgc cgtgcaacca ggccaaggcg    480

tcggacgtgc aggacctcct gaaggatctg aaggctcagt cgcaggtgtt gggctggatc    540

ttgatagcag ttgttatcat cattcttctg atttttacat ctgtcacccg atgcctatct    600

ccagttagtt ttctgcagct gaaattctgg aaaatctatt tggaacagga gcagcagatc    660

cttaaaagta aagccacaga gcatgcaact gaattggcaa aagagaatat taaatgtttc    720

tttgagggct cgcatccaaa agaatataac actccaagca tgaaagagtg gcagcaaatt    780

tcatcactgt atactttcaa tccgaagggc cagtactaca gcatgttgca caaatatgtc    840

aacagaaaag agaagactca cagtatcagg tctactgaag gagatacggt gattcctgtt    900

cttggctttg tagattcatc tggtataaac agcactcctg agttagacta caaagacgat    960

gacgacaagt aa                                                        972


<210>  175
<211>  323
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 175

Met Glu Lys Phe Arg Ala Val Leu Asp Leu His Val Lys His His Ser 
1               5                   10                  15      

Ala Leu Gly Tyr Gly Leu Val Thr Leu Leu Thr Ala Gly Gly Glu Arg 
            20                  25                  30          

Ile Phe Ser Ala Val Ala Phe Gln Cys Pro Cys Ser Ala Ala Trp Asn 
        35                  40                  45              

Leu Pro Tyr Gly Leu Val Phe Leu Leu Val Pro Ala Leu Ala Leu Phe 
    50                  55                  60                  

Leu Leu Gly Tyr Val Leu Ser Ala Arg Thr Trp Arg Leu Leu Thr Gly 
65                  70                  75                  80  

Cys Cys Ser Ser Ala Arg Ala Ser Cys Gly Ser Ala Leu Arg Gly Ser 
                85                  90                  95      

Leu Val Cys Ala Gln Ile Ser Ala Ala Ala Ala Leu Ala Pro Leu Thr 
            100                 105                 110         

Trp Val Ala Val Ala Leu Leu Gly Gly Ala Phe Tyr Glu Cys Ala Ala 
        115                 120                 125             

Thr Gly Ser Ala Ala Phe Ala Gln Arg Leu Cys Leu Gly Arg Asn Arg 
    130                 135                 140                 

Ser Cys Ala Ala Glu Leu Pro Leu Val Pro Cys Asn Gln Ala Lys Ala 
145                 150                 155                 160 

Ser Asp Val Gln Asp Leu Leu Lys Asp Leu Lys Ala Gln Ser Gln Val 
                165                 170                 175     

Leu Gly Trp Ile Leu Ile Ala Val Val Ile Ile Ile Leu Leu Ile Phe 
            180                 185                 190         

Thr Ser Val Thr Arg Cys Leu Ser Pro Val Ser Phe Leu Gln Leu Lys 
        195                 200                 205             

Phe Trp Lys Ile Tyr Leu Glu Gln Glu Gln Gln Ile Leu Lys Ser Lys 
    210                 215                 220                 

Ala Thr Glu His Ala Thr Glu Leu Ala Lys Glu Asn Ile Lys Cys Phe 
225                 230                 235                 240 

Phe Glu Gly Ser His Pro Lys Glu Tyr Asn Thr Pro Ser Met Lys Glu 
                245                 250                 255     

Trp Gln Gln Ile Ser Ser Leu Tyr Thr Phe Asn Pro Lys Gly Gln Tyr 
            260                 265                 270         

Tyr Ser Met Leu His Lys Tyr Val Asn Arg Lys Glu Lys Thr His Ser 
        275                 280                 285             

Ile Arg Ser Thr Glu Gly Asp Thr Val Ile Pro Val Leu Gly Phe Val 
    290                 295                 300                 

Asp Ser Ser Gly Ile Asn Ser Thr Pro Glu Leu Asp Tyr Lys Asp Asp 
305                 310                 315                 320 

Asp Asp Lys 
<210>  176

<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 176

tcgtctctgc cgttctcagg                                                 20


<210>  177
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 177

gggatggtat ggagacattt attg                                            24


<210>  178
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 178

ctagctagcc accatggact acaaagacga tgacgacaag agcggcgcct gcacgagcta     60


<210>  179
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 179

cggaattctt atgggactgg tccacatagg                                      30


<210>  180
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 180

ctagctagcc accatgagcg gcgcctgcac gagctac                              37


<210>  181
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 181

ccggaattct tacttgtcgt catcgtcttt gtagtctggg actggtccac ataggtc        57


<210>  182
<211>  597
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 182

atggactaca aagacgatga cgacaagagc ggcgcctgca cgagctacgt gagcgcagag     60

caggaggtgg tgcgcggctt cagctgcccg cggccggggg gcgaggcggc cgctgtcttc    120

tgctgcggct tccgcgacca caagtactgc tgcgacgacc cgcacagctt cttcccctac    180

gagcacagct acatgtggtg gctcagcatt ggcgctctca taggcctgtc cgtagcagca    240

gtggttcttc tcgccttcat tgttaccgcc tgtgtgctct gctacctgtt catcagctct    300

aagccccaca caaagttgga cctgggcttg agcttacaga cagcaggccc tgaggaggtt    360

tctcctgact gccaaggtgt gaacacaggc atggcggcag aagtgccaaa agtgagccct    420

ctccagcaga gttactcctg cttgaacccg cagctggaga gcaatgaggg gcaggctgtg    480

aactccaaac gcctcctcca tcattgcttc atggccacag tgaccaccag tgacattcca    540

ggcagccctg aggaagcctc tgtacccaac cctgacctat gtggaccagt cccataa       597


<210>  183
<211>  597
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 183

atgagcggcg cctgcacgag ctacgtgagc gcagagcagg aggtggtgcg cggcttcagc     60

tgcccgcggc cggggggcga ggcggccgct gtcttctgct gcggcttccg cgaccacaag    120

tactgctgcg acgacccgca cagcttcttc ccctacgagc acagctacat gtggtggctc    180

agcattggcg ctctcatagg cctgtccgta gcagcagtgg ttcttctcgc cttcattgtt    240

accgcctgtg tgctctgcta cctgttcatc agctctaagc cccacacaaa gttggacctg    300

ggcttgagct tacagacagc aggccctgag gaggtttctc ctgactgcca aggtgtgaac    360

acaggcatgg cggcagaagt gccaaaagtg agccctctcc agcagagtta ctcctgcttg    420

aacccgcagc tggagagcaa tgaggggcag gctgtgaact ccaaacgcct cctccatcat    480

tgcttcatgg ccacagtgac caccagtgac attccaggca gccctgagga agcctctgta    540

cccaaccctg acctatgtgg accagtccca gactacaaag acgatgacga caagtaa       597


<210>  184
<211>  198
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 184

Met Asp Tyr Lys Asp Asp Asp Asp Lys Ser Gly Ala Cys Thr Ser Tyr 
1               5                   10                  15      

Val Ser Ala Glu Gln Glu Val Val Arg Gly Phe Ser Cys Pro Arg Pro 
            20                  25                  30          

Gly Gly Glu Ala Ala Ala Val Phe Cys Cys Gly Phe Arg Asp His Lys 
        35                  40                  45              

Tyr Cys Cys Asp Asp Pro His Ser Phe Phe Pro Tyr Glu His Ser Tyr 
    50                  55                  60                  

Met Trp Trp Leu Ser Ile Gly Ala Leu Ile Gly Leu Ser Val Ala Ala 
65                  70                  75                  80  

Val Val Leu Leu Ala Phe Ile Val Thr Ala Cys Val Leu Cys Tyr Leu 
                85                  90                  95      

Phe Ile Ser Ser Lys Pro His Thr Lys Leu Asp Leu Gly Leu Ser Leu 
            100                 105                 110         

Gln Thr Ala Gly Pro Glu Glu Val Ser Pro Asp Cys Gln Gly Val Asn 
        115                 120                 125             

Thr Gly Met Ala Ala Glu Val Pro Lys Val Ser Pro Leu Gln Gln Ser 
    130                 135                 140                 

Tyr Ser Cys Leu Asn Pro Gln Leu Glu Ser Asn Glu Gly Gln Ala Val 
145                 150                 155                 160 

Asn Ser Lys Arg Leu Leu His His Cys Phe Met Ala Thr Val Thr Thr 
                165                 170                 175     

Ser Asp Ile Pro Gly Ser Pro Glu Glu Ala Ser Val Pro Asn Pro Asp 
            180                 185                 190         

Leu Cys Gly Pro Val Pro 
        195             


<210>  185
<211>  198
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 185

Met Ser Gly Ala Cys Thr Ser Tyr Val Ser Ala Glu Gln Glu Val Val 
1               5                   10                  15      

Arg Gly Phe Ser Cys Pro Arg Pro Gly Gly Glu Ala Ala Ala Val Phe 
            20                  25                  30          

Cys Cys Gly Phe Arg Asp His Lys Tyr Cys Cys Asp Asp Pro His Ser 
        35                  40                  45              

Phe Phe Pro Tyr Glu His Ser Tyr Met Trp Trp Leu Ser Ile Gly Ala 
    50                  55                  60                  

Leu Ile Gly Leu Ser Val Ala Ala Val Val Leu Leu Ala Phe Ile Val 
65                  70                  75                  80  

Thr Ala Cys Val Leu Cys Tyr Leu Phe Ile Ser Ser Lys Pro His Thr 
                85                  90                  95      

Lys Leu Asp Leu Gly Leu Ser Leu Gln Thr Ala Gly Pro Glu Glu Val 
            100                 105                 110         

Ser Pro Asp Cys Gln Gly Val Asn Thr Gly Met Ala Ala Glu Val Pro 
        115                 120                 125             

Lys Val Ser Pro Leu Gln Gln Ser Tyr Ser Cys Leu Asn Pro Gln Leu 
    130                 135                 140                 

Glu Ser Asn Glu Gly Gln Ala Val Asn Ser Lys Arg Leu Leu His His 
145                 150                 155                 160 

Cys Phe Met Ala Thr Val Thr Thr Ser Asp Ile Pro Gly Ser Pro Glu 
                165                 170                 175     

Glu Ala Ser Val Pro Asn Pro Asp Leu Cys Gly Pro Val Pro Asp Tyr 
            180                 185                 190         

Lys Asp Asp Asp Asp Lys 
        195             


<210>  186
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 186

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      

Asp Ser 
<210>  187

<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 187

ctagctagcc accatgcagg ctccccgcgc agccctag                             38


<210>  188
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 188

ttacttgtcg tcatcgtctt tgtagtcgga ttcactgtca cttgggttgt gat            53


<210>  189
<211>  576
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 189

atgcaggctc cccgcgcagc cctagtcttc gccctggtga tcgcgctcgt tcccgtcggc     60

cggggtaatt atgaggaatt agaaaactca ggagatacaa ctgtggaatc tgaaagacca    120

aataaagtga ctattccaag cacatttgct gcagtgacca tcaaagaaac attaaatgca    180

aatataaatt ctaccaactt tgctccggat gaaaatcagt tagagtttat actgatggtg    240

ttaatcccat tgattttatt ggtcctctta cttttatccg tggtattcct tgcaacatac    300

tataaaagaa aaagaactaa acaagaacct tctagccaag gatctcagag tgctttacag    360

acatatgaac tgggaagtga aaacgtgaaa gtccctattt ttgaggaaga tacaccctct    420

gttatggaaa ttgaaatgga agagcttgat aaatggatga acagcatgaa tagaaatgcc    480

gactttgaat gtttacctac cttgaaggaa gagaaggaat caaatcacaa cccaagtgac    540

agtgaatccg actacaaaga cgatgacgac aagtaa                              576


<210>  190
<211>  191
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 190

Met Gln Ala Pro Arg Ala Ala Leu Val Phe Ala Leu Val Ile Ala Leu 
1               5                   10                  15      

Val Pro Val Gly Arg Gly Asn Tyr Glu Glu Leu Glu Asn Ser Gly Asp 
            20                  25                  30          

Thr Thr Val Glu Ser Glu Arg Pro Asn Lys Val Thr Ile Pro Ser Thr 
        35                  40                  45              

Phe Ala Ala Val Thr Ile Lys Glu Thr Leu Asn Ala Asn Ile Asn Ser 
    50                  55                  60                  

Thr Asn Phe Ala Pro Asp Glu Asn Gln Leu Glu Phe Ile Leu Met Val 
65                  70                  75                  80  

Leu Ile Pro Leu Ile Leu Leu Val Leu Leu Leu Leu Ser Val Val Phe 
                85                  90                  95      

Leu Ala Thr Tyr Tyr Lys Arg Lys Arg Thr Lys Gln Glu Pro Ser Ser 
            100                 105                 110         

Gln Gly Ser Gln Ser Ala Leu Gln Thr Tyr Glu Leu Gly Ser Glu Asn 
        115                 120                 125             

Val Lys Val Pro Ile Phe Glu Glu Asp Thr Pro Ser Val Met Glu Ile 
    130                 135                 140                 

Glu Met Glu Glu Leu Asp Lys Trp Met Asn Ser Met Asn Arg Asn Ala 
145                 150                 155                 160 

Asp Phe Glu Cys Leu Pro Thr Leu Lys Glu Glu Lys Glu Ser Asn His 
                165                 170                 175     

Asn Pro Ser Asp Ser Glu Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
            180                 185                 190     


<210>  191
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 191

Arg Gly Asn Tyr Glu Glu Leu Glu Asn Ser Gly Asp Thr Thr Val Glu 
1               5                   10                  15      

Ser Glu Arg 
<210>  192

<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 192

Tyr Lys Arg Lys Arg Thr Lys Gln Glu Pro Ser Ser Gln Gly Ser Gln 
1               5                   10                  15      

Ser 
<210>  193

<211>  78
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 193

gtgagcgcgg caggcgaccc gggcgggggc cgggctcccg gagagcccag caggccaaag     60

gctttgtgtc ttccacag                                                   78


<210>  194
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 194

gtaaggaagg caaacaggaa gggttcattc cacagagact ggctgtgt                  48


<210>  195
<211>  20
<212>  DNA
<213>  Artificial 

<220>
<223>  Synthetic polynucleotide

<400> 195

ccctccactg gatacagcct                                                 20


<210>  196
<211>  20
<212>  PRT
<213>  Artificial 

<220>
<223>  Synthetic polypeptide

<400> 196

Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu Asn Pro Thr Leu Pro Ala 
1               5                   10                  15      

Leu Asn Cys Ser 
            20  


<210>  197
<211>  20
<212>  DNA
<213>  Artificial 

<220>
<223>  Synthetic polynucleotide

<400> 197

agctgaggag aacccaactc                                                 20


<210>  198
<211>  20
<212>  DNA
<213>  Artificial 

<220>
<223>  Synthetic polynucleotide

<400> 198

cggagttatt ctggtggctt                                                 20


<210>  199
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 199

Thr Val Gly Gly Tyr Tyr Pro Gly Val Ile Leu Val Ala Ser Ile Val 
1               5                   10                  15      

Phe Ile Ser Phe 
            20  


<210>  200
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 200

Leu Cys Ser Leu Ser Ser Leu Thr Pro Pro Cys Gly Arg Arg Leu Val 
1               5                   10                  15      

Pro Cys Leu Ser Ala Pro Ala Pro Asn Ala Pro Arg Leu Pro Ala Pro 
            20                  25                  30          

Ala Arg Cys 
        35  


<210>  201
<211>  108
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400> 201

gttgtgttca ctctcctcac tgaccccgcc gtgtggtcgc cggctggtgc cttgtctgtc     60

tgccccagcc ccgaatgccc cgagactccc ggcgccggct cggtgcag                 108

