                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  METHODS AND COMPOSITIONS FOR TREATING P.ACNES

<130>  00015-030WO1

<140>  Not yet known
<141>  2009-12-03

<150>  US 61/120,221
<151>  2008-12-05

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment from P. Acnes

<400>  1

Ser Tyr Ser Glu Lys His Leu Gly Val Ala Phe Arg 
1               5                   10          


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Fragment from P. Acnes CAMP factor

<400>  2

Asp Leu Leu Lys Ala Ala Phe Asp Leu Arg 
1               5                   10  


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Fragment from P. Acnes CAMP Factor

<400>  3

Ala Val Leu Leu Thr Ala Asn Pro Ala Ser Thr Ala Lys 
1               5                   10              


<210>  4
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  4
taaggcctct gtcgacgtcg agccgacgac gaccatctcg                             40


<210>  5
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  5
cagaattcgc aagcttggca gccttcttga catcggggga g                           41


<210>  6
<211>  804
<212>  DNA
<213>  Propionibacterium acnes


<220>
<221>  CDS
<222>  (1)..(804)

<400>  6
atg aag aag acc cat ctt gta gct ccc ctc ctt gtc ggc gca atg ctc         48
Met Lys Lys Thr His Leu Val Ala Pro Leu Leu Val Gly Ala Met Leu           
1               5                   10                  15                

gta cca gcg gcg ctg tca gct ccc agt gct cat gct gtc gag ccg acg         96
Val Pro Ala Ala Leu Ser Ala Pro Ser Ala His Ala Val Glu Pro Thr           
            20                  25                  30                    

acg acc atc tcg gcg acc agc acc cac gag ctc tcg gcc agt gac gct        144
Thr Thr Ile Ser Ala Thr Ser Thr His Glu Leu Ser Ala Ser Asp Ala           
        35                  40                  45                        

cgc aat agc atc cag ctt ctg aac gca cat att gcg acc ctt cag tca        192
Arg Asn Ser Ile Gln Leu Leu Asn Ala His Ile Ala Thr Leu Gln Ser           
    50                  55                  60                            

gta cag aaa tcc gtc ccc ggt tct gac tac tct gac cag atc cga gat        240
Val Gln Lys Ser Val Pro Gly Ser Asp Tyr Ser Asp Gln Ile Arg Asp           
65                  70                  75                  80            

ctt ctc aag gct gcc ttc gac ctg cgt ggc ctc atc gag acc ctt gcc        288
Leu Leu Lys Ala Ala Phe Asp Leu Arg Gly Leu Ile Glu Thr Leu Ala           
                85                  90                  95                

cat ggg ggg atc ccg ttc tac gac cct tcg acg atc atg ccg agg atc        336
His Gly Gly Ile Pro Phe Tyr Asp Pro Ser Thr Ile Met Pro Arg Ile           
            100                 105                 110                   

aag ttg gtc gcc acc act att gac acc att cac act gct acc acc act        384
Lys Leu Val Ala Thr Thr Ile Asp Thr Ile His Thr Ala Thr Thr Thr           
        115                 120                 125                       

ctc caa aac aag gtc agc ccc gcc cac gtc gaa ctc ggt ctc gaa gtc        432
Leu Gln Asn Lys Val Ser Pro Ala His Val Glu Leu Gly Leu Glu Val           
    130                 135                 140                           

acc aag gcc gtc ctg ctg acc gct aac cca gcg tcc acc gcc aag gaa        480
Thr Lys Ala Val Leu Leu Thr Ala Asn Pro Ala Ser Thr Ala Lys Glu           
145                 150                 155                 160           

ctc gac gcc gag ggc gcc gcc ctc aag gct cgc ctg gaa aag gtc tcg        528
Leu Asp Ala Glu Gly Ala Ala Leu Lys Ala Arg Leu Glu Lys Val Ser           
                165                 170                 175               

cag tac ccc gac ctc acc ccg aat gac gtt gcc act gtg tac gta cgc        576
Gln Tyr Pro Asp Leu Thr Pro Asn Asp Val Ala Thr Val Tyr Val Arg           
            180                 185                 190                   

acc aac ttc agt aag acg atc tgg cag gtg cgc gcc aac cgt gac cgg        624
Thr Asn Phe Ser Lys Thr Ile Trp Gln Val Arg Ala Asn Arg Asp Arg           
        195                 200                 205                       

tac atc ctt ggt cac aag agc gcc gca gtg tac aag acg ctc aat cac        672
Tyr Ile Leu Gly His Lys Ser Ala Ala Val Tyr Lys Thr Leu Asn His           
    210                 215                 220                           

gcg atc acc aag gcc gtc ggc gtt cga ctg aac cca aag acg acc gta        720
Ala Ile Thr Lys Ala Val Gly Val Arg Leu Asn Pro Lys Thr Thr Val           
225                 230                 235                 240           

ggg aat atc cag gct gca cgc acc gag ctc ctt gcg gcc tat cag acc        768
Gly Asn Ile Gln Ala Ala Arg Thr Glu Leu Leu Ala Ala Tyr Gln Thr           
                245                 250                 255               

gca ttc aac tcc ccc gat gtc aag aag gct gcc tga                        804
Ala Phe Asn Ser Pro Asp Val Lys Lys Ala Ala                               
            260                 265                                       


<210>  7
<211>  267
<212>  PRT
<213>  Propionibacterium acnes

<400>  7

Met Lys Lys Thr His Leu Val Ala Pro Leu Leu Val Gly Ala Met Leu 
1               5                   10                  15      


Val Pro Ala Ala Leu Ser Ala Pro Ser Ala His Ala Val Glu Pro Thr 
            20                  25                  30          


Thr Thr Ile Ser Ala Thr Ser Thr His Glu Leu Ser Ala Ser Asp Ala 
        35                  40                  45              


Arg Asn Ser Ile Gln Leu Leu Asn Ala His Ile Ala Thr Leu Gln Ser 
    50                  55                  60                  


Val Gln Lys Ser Val Pro Gly Ser Asp Tyr Ser Asp Gln Ile Arg Asp 
65                  70                  75                  80  


Leu Leu Lys Ala Ala Phe Asp Leu Arg Gly Leu Ile Glu Thr Leu Ala 
                85                  90                  95      


His Gly Gly Ile Pro Phe Tyr Asp Pro Ser Thr Ile Met Pro Arg Ile 
            100                 105                 110         


Lys Leu Val Ala Thr Thr Ile Asp Thr Ile His Thr Ala Thr Thr Thr 
        115                 120                 125             


Leu Gln Asn Lys Val Ser Pro Ala His Val Glu Leu Gly Leu Glu Val 
    130                 135                 140                 


Thr Lys Ala Val Leu Leu Thr Ala Asn Pro Ala Ser Thr Ala Lys Glu 
145                 150                 155                 160 


Leu Asp Ala Glu Gly Ala Ala Leu Lys Ala Arg Leu Glu Lys Val Ser 
                165                 170                 175     


Gln Tyr Pro Asp Leu Thr Pro Asn Asp Val Ala Thr Val Tyr Val Arg 
            180                 185                 190         


Thr Asn Phe Ser Lys Thr Ile Trp Gln Val Arg Ala Asn Arg Asp Arg 
        195                 200                 205             


Tyr Ile Leu Gly His Lys Ser Ala Ala Val Tyr Lys Thr Leu Asn His 
    210                 215                 220                 


Ala Ile Thr Lys Ala Val Gly Val Arg Leu Asn Pro Lys Thr Thr Val 
225                 230                 235                 240 


Gly Asn Ile Gln Ala Ala Arg Thr Glu Leu Leu Ala Ala Tyr Gln Thr 
                245                 250                 255     


Ala Phe Asn Ser Pro Asp Val Lys Lys Ala Ala 
            260                 265         


<210>  8
<211>  1197
<212>  DNA
<213>  Propionibacterium acnes


<220>
<221>  CDS
<222>  (79)..(1098)

<400>  8
tttttgtagg ctaccctttt cgaattgaat caatatgatt cacgaaattc gccccgtagt       60

tccgctgagg agtcactg atg aag atc aac gca cga ttc gcc gtc atg gcc        111
                    Met Lys Ile Asn Ala Arg Phe Ala Val Met Ala           
                    1               5                   10                

gcg agt gtg gcc gtc ctg atg gct gcc gcg ccg att gcg cag gct gct        159
Ala Ser Val Ala Val Leu Met Ala Ala Ala Pro Ile Ala Gln Ala Ala           
            15                  20                  25                    

act tcg ccg ggg gat atc cat ccc ctg gtc cag gca gcc cac agc ccc        207
Thr Ser Pro Gly Asp Ile His Pro Leu Val Gln Ala Ala His Ser Pro           
        30                  35                  40                        

gac ggt att ccc ggt aac ggc gtc ggg ccg gaa ttc cat acg tcg tcg        255
Asp Gly Ile Pro Gly Asn Gly Val Gly Pro Glu Phe His Thr Ser Ser           
    45                  50                  55                            

atg gcg cgt tcc tac agc gag aag cac ctg ggc gtg gcg ccg cgg ggt        303
Met Ala Arg Ser Tyr Ser Glu Lys His Leu Gly Val Ala Pro Arg Gly           
60                  65                  70                  75            

gtg aac gac ttc tcc tgc aag gtc aag ccc ggc gac cga ccg gtc atc        351
Val Asn Asp Phe Ser Cys Lys Val Lys Pro Gly Asp Arg Pro Val Ile           
                80                  85                  90                

ctg att ccc ggt act ggc ggc aat gcg ttc gcc aca tgg tcc ttc tac        399
Leu Ile Pro Gly Thr Gly Gly Asn Ala Phe Ala Thr Trp Ser Phe Tyr           
            95                  100                 105                   

gga ccc cat ctg gcc cat gag ggg tac tgt gtc tac acc ttc acc acc        447
Gly Pro His Leu Ala His Glu Gly Tyr Cys Val Tyr Thr Phe Thr Thr           
        110                 115                 120                       

aat gtc ccc gtg ggg atc ctc gac gag ggc tgg ggc ttc acc ggt gac        495
Asn Val Pro Val Gly Ile Leu Asp Glu Gly Trp Gly Phe Thr Gly Asp           
    125                 130                 135                           

gtg cgc gcc tcc gcg cag gcg ctg ggt gcc ttt gtg gat cgg gtc cgg        543
Val Arg Ala Ser Ala Gln Ala Leu Gly Ala Phe Val Asp Arg Val Arg           
140                 145                 150                 155           

aaa gcg acg ggc tct gag aag gtc gac ttc gtc gga cat tcg cag ggt        591
Lys Ala Thr Gly Ser Glu Lys Val Asp Phe Val Gly His Ser Gln Gly           
                160                 165                 170               

ggc ggc atc ctg ccg aac gcc tac atc aag atg tat ggc gga gcg tcc        639
Gly Gly Ile Leu Pro Asn Ala Tyr Ile Lys Met Tyr Gly Gly Ala Ser           
            175                 180                 185                   

aag gtc gac aag ctg atc gga ctg gtg gcc gcc aac cac ggc acc acc        687
Lys Val Asp Lys Leu Ile Gly Leu Val Ala Ala Asn His Gly Thr Thr           
        190                 195                 200                       

gcc gtc ggt ctc gac aag ctt gtc gac ggc ctg ccc gag gct gtg aag        735
Ala Val Gly Leu Asp Lys Leu Val Asp Gly Leu Pro Glu Ala Val Lys           
    205                 210                 215                           

gat ttc ctt agc acg tgg agc tac gac cac aac atg gag gcc tac ggc        783
Asp Phe Leu Ser Thr Trp Ser Tyr Asp His Asn Met Glu Ala Tyr Gly           
220                 225                 230                 235           

cag cag ctc aag gga tca gcg ttg atg caa cag gtt tac cgt gac ggc        831
Gln Gln Leu Lys Gly Ser Ala Leu Met Gln Gln Val Tyr Arg Asp Gly           
                240                 245                 250               

gac acc gtc ccg ggt atc gcc tac acc gtc atc tcc acc cgg ctc gac        879
Asp Thr Val Pro Gly Ile Ala Tyr Thr Val Ile Ser Thr Arg Leu Asp           
            255                 260                 265                   

atg acg gtc acg ccc tac acg caa gcc ttc ctc aag ggc gcc aag aac        927
Met Thr Val Thr Pro Tyr Thr Gln Ala Phe Leu Lys Gly Ala Lys Asn           
        270                 275                 280                       

atg acc gtg cag gac gcc tgc cct ctg gat gcc tat ggc cac ggc cgc        975
Met Thr Val Gln Asp Ala Cys Pro Leu Asp Ala Tyr Gly His Gly Arg           
    285                 290                 295                           

cta ccc tat gat ccc gtc gcc tac cag atg gtg ctc aac gcc ctc gat       1023
Leu Pro Tyr Asp Pro Val Ala Tyr Gln Met Val Leu Asn Ala Leu Asp           
300                 305                 310                 315           

ccg aac cac cca cga gag atc tcc tgc acg tgg cgg ccc cgg gtt ctg       1071
Pro Asn His Pro Arg Glu Ile Ser Cys Thr Trp Arg Pro Arg Val Leu           
                320                 325                 330               

ccc gta tcc acc acg gat gct gca tga actgtggcag gtcagggttc             1118
Pro Val Ser Thr Thr Asp Ala Ala                                           
            335                                                           

tccagcgccg tgcggcgtgg ccaccaacca cgactgtggt gacaacgaac agtactcggt     1178

ccctgccttg tgccgggtg                                                  1197


<210>  9
<211>  339
<212>  PRT
<213>  Propionibacterium acnes

<400>  9

Met Lys Ile Asn Ala Arg Phe Ala Val Met Ala Ala Ser Val Ala Val 
1               5                   10                  15      


Leu Met Ala Ala Ala Pro Ile Ala Gln Ala Ala Thr Ser Pro Gly Asp 
            20                  25                  30          


Ile His Pro Leu Val Gln Ala Ala His Ser Pro Asp Gly Ile Pro Gly 
        35                  40                  45              


Asn Gly Val Gly Pro Glu Phe His Thr Ser Ser Met Ala Arg Ser Tyr 
    50                  55                  60                  


Ser Glu Lys His Leu Gly Val Ala Pro Arg Gly Val Asn Asp Phe Ser 
65                  70                  75                  80  


Cys Lys Val Lys Pro Gly Asp Arg Pro Val Ile Leu Ile Pro Gly Thr 
                85                  90                  95      


Gly Gly Asn Ala Phe Ala Thr Trp Ser Phe Tyr Gly Pro His Leu Ala 
            100                 105                 110         


His Glu Gly Tyr Cys Val Tyr Thr Phe Thr Thr Asn Val Pro Val Gly 
        115                 120                 125             


Ile Leu Asp Glu Gly Trp Gly Phe Thr Gly Asp Val Arg Ala Ser Ala 
    130                 135                 140                 


Gln Ala Leu Gly Ala Phe Val Asp Arg Val Arg Lys Ala Thr Gly Ser 
145                 150                 155                 160 


Glu Lys Val Asp Phe Val Gly His Ser Gln Gly Gly Gly Ile Leu Pro 
                165                 170                 175     


Asn Ala Tyr Ile Lys Met Tyr Gly Gly Ala Ser Lys Val Asp Lys Leu 
            180                 185                 190         


Ile Gly Leu Val Ala Ala Asn His Gly Thr Thr Ala Val Gly Leu Asp 
        195                 200                 205             


Lys Leu Val Asp Gly Leu Pro Glu Ala Val Lys Asp Phe Leu Ser Thr 
    210                 215                 220                 


Trp Ser Tyr Asp His Asn Met Glu Ala Tyr Gly Gln Gln Leu Lys Gly 
225                 230                 235                 240 


Ser Ala Leu Met Gln Gln Val Tyr Arg Asp Gly Asp Thr Val Pro Gly 
                245                 250                 255     


Ile Ala Tyr Thr Val Ile Ser Thr Arg Leu Asp Met Thr Val Thr Pro 
            260                 265                 270         


Tyr Thr Gln Ala Phe Leu Lys Gly Ala Lys Asn Met Thr Val Gln Asp 
        275                 280                 285             


Ala Cys Pro Leu Asp Ala Tyr Gly His Gly Arg Leu Pro Tyr Asp Pro 
    290                 295                 300                 


Val Ala Tyr Gln Met Val Leu Asn Ala Leu Asp Pro Asn His Pro Arg 
305                 310                 315                 320 


Glu Ile Ser Cys Thr Trp Arg Pro Arg Val Leu Pro Val Ser Thr Thr 
                325                 330                 335     


Asp Ala Ala 
            


<210>  10
<211>  1896
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1896)

<400>  10
atg ccc cgc tac gga gcg tca ctc cgc cag agc tgc ccc agg tcc ggc         48
Met Pro Arg Tyr Gly Ala Ser Leu Arg Gln Ser Cys Pro Arg Ser Gly           
1               5                   10                  15                

cgg gag cag gga caa gac ggg acc gcc gga gcc ccc gga ctc ctt tgg         96
Arg Glu Gln Gly Gln Asp Gly Thr Ala Gly Ala Pro Gly Leu Leu Trp           
            20                  25                  30                    

atg ggc ctg gtg ctg gcg ctg gcg ctg gcg ctg gcg ctg gcg ctg gct        144
Met Gly Leu Val Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala           
        35                  40                  45                        

ctg tct gac tct cgg gtt ctc tgg gct ccg gca gag gct cac cct ctt        192
Leu Ser Asp Ser Arg Val Leu Trp Ala Pro Ala Glu Ala His Pro Leu           
    50                  55                  60                            

tct ccc caa ggc cat cct gcc agg tta cat cgc ata gtg ccc cgg ctc        240
Ser Pro Gln Gly His Pro Ala Arg Leu His Arg Ile Val Pro Arg Leu           
65                  70                  75                  80            

cga gat gtc ttt ggg tgg ggg aac ctc acc tgc cca atc tgc aaa ggt        288
Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys Lys Gly           
                85                  90                  95                

cta ttc acc gcc atc aac ctc ggg ctg aag aag gaa ccc aat gtg gct        336
Leu Phe Thr Ala Ile Asn Leu Gly Leu Lys Lys Glu Pro Asn Val Ala           
            100                 105                 110                   

cgc gtg ggc tcc gtg gcc atc aag ctg tgc aat ctg ctg aag ata gca        384
Arg Val Gly Ser Val Ala Ile Lys Leu Cys Asn Leu Leu Lys Ile Ala           
        115                 120                 125                       

cca cct gcc gtg tgc caa tcc att gtc cac ctc ttt gag gat gac atg        432
Pro Pro Ala Val Cys Gln Ser Ile Val His Leu Phe Glu Asp Asp Met           
    130                 135                 140                           

gtg gag gtg tgg aga cgc tca gtg ctg agc cca tct gag gcc tgt ggc        480
Val Glu Val Trp Arg Arg Ser Val Leu Ser Pro Ser Glu Ala Cys Gly           
145                 150                 155                 160           

ctg ctc ctg ggc tcc acc tgt ggg cac tgg gac att ttc tca tct tgg        528
Leu Leu Leu Gly Ser Thr Cys Gly His Trp Asp Ile Phe Ser Ser Trp           
                165                 170                 175               

aac atc tct ttg cct act gtg ccg aag ccg ccc ccc aaa ccc cct agc        576
Asn Ile Ser Leu Pro Thr Val Pro Lys Pro Pro Pro Lys Pro Pro Ser           
            180                 185                 190                   

ccc cca gcc cca ggt gcc cct gtc agc cgc atc ctc ttc ctc act gac        624
Pro Pro Ala Pro Gly Ala Pro Val Ser Arg Ile Leu Phe Leu Thr Asp           
        195                 200                 205                       

ctg cac tgg gat cat gac tac ctg gag ggc acg gac cct gac tgt gca        672
Leu His Trp Asp His Asp Tyr Leu Glu Gly Thr Asp Pro Asp Cys Ala           
    210                 215                 220                           

gac cca ctg tgc tgc cgc cgg ggt tct ggc ctg ccg ccc gca tcc cgg        720
Asp Pro Leu Cys Cys Arg Arg Gly Ser Gly Leu Pro Pro Ala Ser Arg           
225                 230                 235                 240           

cca ggt gcc gga tac tgg ggc gaa tac agc aag tgt gac ctg ccc ctg        768
Pro Gly Ala Gly Tyr Trp Gly Glu Tyr Ser Lys Cys Asp Leu Pro Leu           
                245                 250                 255               

agg acc ctg gag agc ctg ttg agt ggg ctg ggc cca gcc ggc cct ttt        816
Arg Thr Leu Glu Ser Leu Leu Ser Gly Leu Gly Pro Ala Gly Pro Phe           
            260                 265                 270                   

gat atg gtg tac tgg aca gga gac atc ccc gca cat gat gtc tgg cac        864
Asp Met Val Tyr Trp Thr Gly Asp Ile Pro Ala His Asp Val Trp His           
        275                 280                 285                       

cag act cgt cag gac caa ctg cgg gcc ctg acc acc gtc aca gca ctt        912
Gln Thr Arg Gln Asp Gln Leu Arg Ala Leu Thr Thr Val Thr Ala Leu           
    290                 295                 300                           

gtg agg aag ttc ctg ggg cca gtg cca gtg tac cct gct gtg ggt aac        960
Val Arg Lys Phe Leu Gly Pro Val Pro Val Tyr Pro Ala Val Gly Asn           
305                 310                 315                 320           

cat gaa agc aca cct gtc aat agc ttc cct ccc ccc ttc att gag ggc       1008
His Glu Ser Thr Pro Val Asn Ser Phe Pro Pro Pro Phe Ile Glu Gly           
                325                 330                 335               

aac cac tcc tcc cgc tgg ctc tat gaa gcg atg gcc aag gct tgg gag       1056
Asn His Ser Ser Arg Trp Leu Tyr Glu Ala Met Ala Lys Ala Trp Glu           
            340                 345                 350                   

ccc tgg ctg cct gcc gaa gcc ctg cgc acc ctc aga att ggg ggg ttc       1104
Pro Trp Leu Pro Ala Glu Ala Leu Arg Thr Leu Arg Ile Gly Gly Phe           
        355                 360                 365                       

tat gct ctt tcc cca tac ccc ggt ctc cgc ctc atc tct ctc aat atg       1152
Tyr Ala Leu Ser Pro Tyr Pro Gly Leu Arg Leu Ile Ser Leu Asn Met           
    370                 375                 380                           

aat ttt tgt tcc cgt gag aac ttc tgg ctc ttg atc aac tcc acg gat       1200
Asn Phe Cys Ser Arg Glu Asn Phe Trp Leu Leu Ile Asn Ser Thr Asp           
385                 390                 395                 400           

ccc gca gga cag ctc cag tgg ctg gtg ggg gag ctt cag gct gct gag       1248
Pro Ala Gly Gln Leu Gln Trp Leu Val Gly Glu Leu Gln Ala Ala Glu           
                405                 410                 415               

gat cga gga gac aaa gtg cat ata att ggc cac att ccc cca ggg cac       1296
Asp Arg Gly Asp Lys Val His Ile Ile Gly His Ile Pro Pro Gly His           
            420                 425                 430                   

tgt ctg aag agc tgg agc tgg aat tat tac cga att gta gcc agg tat       1344
Cys Leu Lys Ser Trp Ser Trp Asn Tyr Tyr Arg Ile Val Ala Arg Tyr           
        435                 440                 445                       

gag aac acc ctg gct gct cag ttc ttt ggc cac act cat gtg gat gaa       1392
Glu Asn Thr Leu Ala Ala Gln Phe Phe Gly His Thr His Val Asp Glu           
    450                 455                 460                           

ttt gag gtc ttc tat gat gaa gag act ctg agc cgg ccg ctg gct gta       1440
Phe Glu Val Phe Tyr Asp Glu Glu Thr Leu Ser Arg Pro Leu Ala Val           
465                 470                 475                 480           

gcc ttc ctg gca ccc agt gca act acc tac atc ggc ctt aat cct ggt       1488
Ala Phe Leu Ala Pro Ser Ala Thr Thr Tyr Ile Gly Leu Asn Pro Gly           
                485                 490                 495               

tac cgt gtg tac caa ata gat gga aac tac tcc ggg agc tct cac gtg       1536
Tyr Arg Val Tyr Gln Ile Asp Gly Asn Tyr Ser Gly Ser Ser His Val           
            500                 505                 510                   

gtc ctg gac cat gag acc tac atc ctg aat ctg acc cag gca aac ata       1584
Val Leu Asp His Glu Thr Tyr Ile Leu Asn Leu Thr Gln Ala Asn Ile           
        515                 520                 525                       

ccg gga gcc ata ccg cac tgg cag ctt ctc tac agg gct cga gaa acc       1632
Pro Gly Ala Ile Pro His Trp Gln Leu Leu Tyr Arg Ala Arg Glu Thr           
    530                 535                 540                           

tat ggg ctg ccc aac aca ctg cct acc gcc tgg cac aac ctg gta tat       1680
Tyr Gly Leu Pro Asn Thr Leu Pro Thr Ala Trp His Asn Leu Val Tyr           
545                 550                 555                 560           

cgc atg cgg ggc gac atg caa ctt ttc cag acc ttc tgg ttt ctc tac       1728
Arg Met Arg Gly Asp Met Gln Leu Phe Gln Thr Phe Trp Phe Leu Tyr           
                565                 570                 575               

cat aag ggc cac cca ccc tcg gag ccc tgt ggc acg ccc tgc cgt ctg       1776
His Lys Gly His Pro Pro Ser Glu Pro Cys Gly Thr Pro Cys Arg Leu           
            580                 585                 590                   

gct act ctt tgt gcc cag ctc tct gcc cgt gct gac agc cct gct ctg       1824
Ala Thr Leu Cys Ala Gln Leu Ser Ala Arg Ala Asp Ser Pro Ala Leu           
        595                 600                 605                       

tgc cgc cac ctg atg cca gat ggg agc ctc cca gag gcc cag agc ctg       1872
Cys Arg His Leu Met Pro Asp Gly Ser Leu Pro Glu Ala Gln Ser Leu           
    610                 615                 620                           

tgg cca agg cca ctg ttt tgc tag                                       1896
Trp Pro Arg Pro Leu Phe Cys                                               
625                 630                                                   


<210>  11
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Arg Tyr Gly Ala Ser Leu Arg Gln Ser Cys Pro Arg Ser Gly 
1               5                   10                  15      


Arg Glu Gln Gly Gln Asp Gly Thr Ala Gly Ala Pro Gly Leu Leu Trp 
            20                  25                  30          


Met Gly Leu Val Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala 
        35                  40                  45              


Leu Ser Asp Ser Arg Val Leu Trp Ala Pro Ala Glu Ala His Pro Leu 
    50                  55                  60                  


Ser Pro Gln Gly His Pro Ala Arg Leu His Arg Ile Val Pro Arg Leu 
65                  70                  75                  80  


Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys Lys Gly 
                85                  90                  95      


Leu Phe Thr Ala Ile Asn Leu Gly Leu Lys Lys Glu Pro Asn Val Ala 
            100                 105                 110         


Arg Val Gly Ser Val Ala Ile Lys Leu Cys Asn Leu Leu Lys Ile Ala 
        115                 120                 125             


Pro Pro Ala Val Cys Gln Ser Ile Val His Leu Phe Glu Asp Asp Met 
    130                 135                 140                 


Val Glu Val Trp Arg Arg Ser Val Leu Ser Pro Ser Glu Ala Cys Gly 
145                 150                 155                 160 


Leu Leu Leu Gly Ser Thr Cys Gly His Trp Asp Ile Phe Ser Ser Trp 
                165                 170                 175     


Asn Ile Ser Leu Pro Thr Val Pro Lys Pro Pro Pro Lys Pro Pro Ser 
            180                 185                 190         


Pro Pro Ala Pro Gly Ala Pro Val Ser Arg Ile Leu Phe Leu Thr Asp 
        195                 200                 205             


Leu His Trp Asp His Asp Tyr Leu Glu Gly Thr Asp Pro Asp Cys Ala 
    210                 215                 220                 


Asp Pro Leu Cys Cys Arg Arg Gly Ser Gly Leu Pro Pro Ala Ser Arg 
225                 230                 235                 240 


Pro Gly Ala Gly Tyr Trp Gly Glu Tyr Ser Lys Cys Asp Leu Pro Leu 
                245                 250                 255     


Arg Thr Leu Glu Ser Leu Leu Ser Gly Leu Gly Pro Ala Gly Pro Phe 
            260                 265                 270         


Asp Met Val Tyr Trp Thr Gly Asp Ile Pro Ala His Asp Val Trp His 
        275                 280                 285             


Gln Thr Arg Gln Asp Gln Leu Arg Ala Leu Thr Thr Val Thr Ala Leu 
    290                 295                 300                 


Val Arg Lys Phe Leu Gly Pro Val Pro Val Tyr Pro Ala Val Gly Asn 
305                 310                 315                 320 


His Glu Ser Thr Pro Val Asn Ser Phe Pro Pro Pro Phe Ile Glu Gly 
                325                 330                 335     


Asn His Ser Ser Arg Trp Leu Tyr Glu Ala Met Ala Lys Ala Trp Glu 
            340                 345                 350         


Pro Trp Leu Pro Ala Glu Ala Leu Arg Thr Leu Arg Ile Gly Gly Phe 
        355                 360                 365             


Tyr Ala Leu Ser Pro Tyr Pro Gly Leu Arg Leu Ile Ser Leu Asn Met 
    370                 375                 380                 


Asn Phe Cys Ser Arg Glu Asn Phe Trp Leu Leu Ile Asn Ser Thr Asp 
385                 390                 395                 400 


Pro Ala Gly Gln Leu Gln Trp Leu Val Gly Glu Leu Gln Ala Ala Glu 
                405                 410                 415     


Asp Arg Gly Asp Lys Val His Ile Ile Gly His Ile Pro Pro Gly His 
            420                 425                 430         


Cys Leu Lys Ser Trp Ser Trp Asn Tyr Tyr Arg Ile Val Ala Arg Tyr 
        435                 440                 445             


Glu Asn Thr Leu Ala Ala Gln Phe Phe Gly His Thr His Val Asp Glu 
    450                 455                 460                 


Phe Glu Val Phe Tyr Asp Glu Glu Thr Leu Ser Arg Pro Leu Ala Val 
465                 470                 475                 480 


Ala Phe Leu Ala Pro Ser Ala Thr Thr Tyr Ile Gly Leu Asn Pro Gly 
                485                 490                 495     


Tyr Arg Val Tyr Gln Ile Asp Gly Asn Tyr Ser Gly Ser Ser His Val 
            500                 505                 510         


Val Leu Asp His Glu Thr Tyr Ile Leu Asn Leu Thr Gln Ala Asn Ile 
        515                 520                 525             


Pro Gly Ala Ile Pro His Trp Gln Leu Leu Tyr Arg Ala Arg Glu Thr 
    530                 535                 540                 


Tyr Gly Leu Pro Asn Thr Leu Pro Thr Ala Trp His Asn Leu Val Tyr 
545                 550                 555                 560 


Arg Met Arg Gly Asp Met Gln Leu Phe Gln Thr Phe Trp Phe Leu Tyr 
                565                 570                 575     


His Lys Gly His Pro Pro Ser Glu Pro Cys Gly Thr Pro Cys Arg Leu 
            580                 585                 590         


Ala Thr Leu Cys Ala Gln Leu Ser Ala Arg Ala Asp Ser Pro Ala Leu 
        595                 600                 605             


Cys Arg His Leu Met Pro Asp Gly Ser Leu Pro Glu Ala Gln Ser Leu 
    610                 615                 620                 


Trp Pro Arg Pro Leu Phe Cys 
625                 630     


<210>  12
<211>  1509
<212>  DNA
<213>  Propionibacterium acnes

<400>  12
tcagtctcct gtgtgcggca aactagtggg acgcgacgag gcacctccgt gaagagaacc       60

ggagggggtc gcagtaagcg ggagagatgt gccagaagtt ggctctccag aagtcggcct      120

cccggaagga gccaccgggc acacggaatt caaccacccc atcggaatgg tggagtaccg      180

aataccgtcg cgctcccaca gaacgcccaa cgccccgtca gactgcaccg ctgccgtggt      240

gtatccgact tccccgggca tgtaggtctg atgactgacc catgtccgtc cgtcatcgca      300

ggagaccgag agggtaccgt ttacccgttc cgtggcattg cgggcattcg tgaataacag      360

gatcctggct ttcgccgacc cggcccgggc attggggtaa gcccgaatga tctgggcgtt      420

gttggtgggg tcgatgaggt cgtcgaccag cttcaccggc ccccaggtca agccaccgtc      480

atgggaatag gccactttgc gccgaccgga acgggctgcg tccctggaat tgagcatgag      540

ggtaccgtcg gacagttcca ccaccttgtt ctcgtccatc attcggccca ccgggttgcc      600

agcatgccag gtgatgccgt gatcatcgga atagatcgac tgggcctgtt ggccgacact      660

gttgcgcacc gtcatctggg caatgagacc tccagcgtgg gggccgtgga gcaacgctat      720

gccctgccct gatgccacga atcgtgtccg agtggtggga tccggggtga tctcgcgcgt      780

gatgtctcga taggtccaag tgtgtccatt gtcggtcgat gtagagacct cggcgtgcag      840

aacatgacga tcatccgggt ccgtgcccac ctccgatgtg gcgaatcctc tgtcgtagga      900

cttcacgtga aaattgagga tgtggcccgt ggctggatcg acgagatagg aaggatcgga      960

gtatcccacc ttcctgcgac ccagggtccc ggcatggatg acggtttgcg gaccccgcgt     1020

cctaccgttg tcgcgagagc ggcgctgcac gatggaattg gggttaggcg catcggcggc     1080

gctccccgga cgcagatcgt aggaggccag caaatcgccg ttcgaagcgg tcgcaagggc     1140

tgggattcgg taaaaaacac ctgccggatg ctcattgaca gccaaatcca cgacggggcc     1200

aaggagcatc cgtgtgctcg aatcagcacg aacatccggc agaggtgccg gcactgctgc     1260

gggccatgtc cggtcgactt tcataatggc tcccttggcg ttccggacga tattcttacc     1320

gaagaagaga tgagtgcccg actgatcggt gctggtgata tcacccgtga cgagcttcgg     1380

ctgggtggtg gccgcatctg gggccggagc cctgcctgat gccatagctg actgcgtcac     1440

catgggagcc ccgatgacgg ccatgattcc ggcaatggcc aacgcgctca gtttcgtggt     1500

caaagtcat                                                             1509


<210>  13
<211>  502
<212>  PRT
<213>  Propionibacterium acnes

<400>  13

Met Thr Leu Thr Thr Lys Leu Ser Ala Leu Ala Ile Ala Gly Ile Met 
1               5                   10                  15      


Ala Val Ile Gly Ala Pro Met Val Thr Gln Ser Ala Met Ala Ser Gly 
            20                  25                  30          


Arg Ala Pro Ala Pro Asp Ala Ala Thr Thr Gln Pro Lys Leu Val Thr 
        35                  40                  45              


Gly Asp Ile Thr Ser Thr Asp Gln Ser Gly Thr His Leu Phe Phe Gly 
    50                  55                  60                  


Lys Asn Ile Val Arg Asn Ala Lys Gly Ala Ile Met Lys Val Asp Arg 
65                  70                  75                  80  


Thr Trp Pro Ala Ala Val Pro Ala Pro Leu Pro Asp Val Arg Ala Asp 
                85                  90                  95      


Ser Ser Thr Arg Met Leu Leu Gly Pro Val Val Asp Leu Ala Val Asn 
            100                 105                 110         


Glu His Pro Ala Gly Val Phe Tyr Arg Ile Pro Ala Leu Ala Thr Ala 
        115                 120                 125             


Ser Asn Gly Asp Leu Leu Ala Ser Tyr Asp Leu Arg Pro Gly Ser Ala 
    130                 135                 140                 


Ala Asp Ala Pro Asn Pro Asn Ser Ile Val Gln Arg Arg Ser Arg Asp 
145                 150                 155                 160 


Asn Gly Arg Thr Arg Gly Pro Gln Thr Val Ile His Ala Gly Thr Leu 
                165                 170                 175     


Gly Arg Arg Lys Val Gly Tyr Ser Asp Pro Ser Tyr Leu Val Asp Pro 
            180                 185                 190         


Ala Thr Gly His Ile Leu Asn Phe His Val Lys Ser Tyr Asp Arg Gly 
        195                 200                 205             


Phe Ala Thr Ser Glu Val Gly Thr Asp Pro Asp Asp Arg His Val Leu 
    210                 215                 220                 


His Ala Glu Val Ser Thr Ser Thr Asp Asn Gly His Thr Trp Thr Tyr 
225                 230                 235                 240 


Arg Asp Ile Thr Arg Glu Ile Thr Pro Asp Pro Thr Thr Arg Thr Arg 
                245                 250                 255     


Phe Val Ala Ser Gly Gln Gly Ile Ala Leu Leu His Gly Pro His Ala 
            260                 265                 270         


Gly Gly Leu Ile Ala Gln Met Thr Val Arg Asn Ser Val Gly Gln Gln 
        275                 280                 285             


Ala Gln Ser Ile Tyr Ser Asp Asp His Gly Ile Thr Trp His Ala Gly 
    290                 295                 300                 


Asn Pro Val Gly Arg Met Met Asp Glu Asn Lys Val Val Glu Leu Ser 
305                 310                 315                 320 


Asp Gly Thr Leu Met Leu Asn Ser Arg Asp Ala Ala Arg Ser Gly Arg 
                325                 330                 335     


Arg Lys Val Ala Tyr Ser His Asp Gly Gly Leu Thr Trp Gly Pro Val 
            340                 345                 350         


Lys Leu Val Asp Asp Leu Ile Asp Pro Thr Asn Asn Ala Gln Ile Ile 
        355                 360                 365             


Arg Ala Tyr Pro Asn Ala Arg Ala Gly Ser Ala Lys Ala Arg Ile Leu 
    370                 375                 380                 


Leu Phe Thr Asn Ala Arg Asn Ala Thr Glu Arg Val Asn Gly Thr Leu 
385                 390                 395                 400 


Ser Val Ser Cys Asp Asp Gly Arg Thr Trp Val Ser His Gln Thr Tyr 
                405                 410                 415     


Met Pro Gly Glu Val Gly Tyr Thr Thr Ala Ala Val Gln Ser Asp Gly 
            420                 425                 430         


Ala Leu Gly Val Leu Trp Glu Arg Asp Gly Ile Arg Tyr Ser Thr Ile 
        435                 440                 445             


Pro Met Gly Trp Leu Asn Ser Val Cys Pro Val Ala Pro Ser Gly Arg 
    450                 455                 460                 


Pro Thr Ser Gly Glu Pro Thr Ser Gly Thr Ser Leu Pro Leu Thr Ala 
465                 470                 475                 480 


Thr Pro Ser Gly Ser Leu His Gly Gly Ala Ser Ser Arg Pro Thr Ser 
                485                 490                 495     


Leu Pro His Thr Gly Asp 
            500         


<210>  14
<211>  1692
<212>  DNA
<213>  Propionibacterium acnes

<400>  14
tcaggacgcc agttcctgca ggtacatacg ttggagcccg tccgcccacg agtccgtagg       60

tgacgattcg aagagcacga gaacacgtcc gtcagacaac tgggcgatcg aggaataggc      120

gaagagggtc tgtgggctcg tgatgtcggc gtgactcacc cattcaagtt cggagcgcgg      180

tccgaacgtt ctcgaggatc gatggacaac tgccacatgg gcaatgccat gtcgacgcct      240

gcggtcatct gctgagacga caatgagcgc agggagctgt tccccggtcg taggtgatgc      300

gatggtttgc ttcagcatga gcgcggagac ttggcatgcg acgccttggt cgtcgtcgcc      360

gaacgcggaa gtcagcgtac tccaggaatg gccgccatcc acgctctcgg cggtcagcac      420

cttcccaccg gaagaagcgg aatgtcggtt gaagctgcgc aatacgccgg gtagaacctc      480

tgtgatcgcg ctttcgtgga ggtcgatagt ggctggcatc ggggttcccc gctgccacgt      540

ttccccacca tcgtcggtgt atacagtggt gcacgaaatt cctgcaggta gcatcatgta      600

agtcggaacg acgatgcgtc cggcatgttc ccctgcgcgg atttgaatgg accgacctgg      660

tgcgacgagc gtgtatcgag aatctacggg tctgaactgc cgtgtcacca gttttcccat      720

gttccaagtt cggccatcgt catatgagta gatctccacg atgtgattgg tgttgaagac      780

ctgaaggatc gagtccttgt agaagacgcg catcggagtg atgcgagctg aaccgtgctg      840

gaacacgtac agaggaattc ctgcttcgaa gaggttgaaa ccgtcgtcca aggagtatct      900

tgatcgtcgt cctagagcga gatttgagtc atcgactccg gcggtggtgt acgggcgagg      960

tataccgatt aattcataaa tctgaatgcg accgtgcttg tcgcgggggc cgtcgaggtc     1020

agctacgagg tcgaattggg aacggtcgat gttcagattg atatttcccc tcaatccgtc     1080

ggcgtcccct gtgacgttgt gcgtcgagag caggagcatg tcacgtccgg caacggtggc     1140

gaagccatct cccaggggga actttcgcgg gcgcccaccg ttgacggggc catctgggga     1200

gacgttgagg tgttcgaata ctccgccgtt ccaggcccag agatcaatga cgatcatcag     1260

tcgatgtcga actgaatcct cgatgatggc gccgtcgatg acggaggatg atgcgggggc     1320

gtacccatac ttgttcgaat aatctcgcat ctccaatggt tttatcagtg acggggcttc     1380

ccaaccgtcg gagattgagt aacgggatgc attgggtttt ctgcgaatca gggcatcgat     1440

attgtcggcg gagtcgcctg ttgtcgcgcg atttgcatcg cagcctatga ccaatgtgtc     1500

attggccgta gacaccatga acggtatgcg gaaaaaatgt gatggcgaat tctctctgtt     1560

gaacacctcg agtacgtctg cctcttgtgt cgcaagtgca ggagagtgtt cagagaactg     1620

ccctgtcaca ctcaagaata aggctgcccc gccagagatt aatgcggatc ggcgtgaaat     1680

ccgttggtgc at                                                         1692


<210>  15
<211>  563
<212>  PRT
<213>  Propionibacterium acnes

<400>  15

Met His Gln Arg Ile Ser Arg Arg Ser Ala Leu Ile Ser Gly Gly Ala 
1               5                   10                  15      


Ala Leu Phe Leu Ser Val Thr Gly Gln Phe Ser Glu His Ser Pro Ala 
            20                  25                  30          


Leu Ala Thr Gln Glu Ala Asp Val Leu Glu Val Phe Asn Arg Glu Asn 
        35                  40                  45              


Ser Pro Ser His Phe Phe Arg Ile Pro Phe Met Val Ser Thr Ala Asn 
    50                  55                  60                  


Asp Thr Leu Val Ile Gly Cys Asp Ala Asn Arg Ala Thr Thr Gly Asp 
65                  70                  75                  80  


Ser Ala Asp Asn Ile Asp Ala Leu Ile Arg Arg Lys Pro Asn Ala Ser 
                85                  90                  95      


Arg Tyr Ser Ile Ser Asp Gly Trp Glu Ala Pro Ser Leu Ile Lys Pro 
            100                 105                 110         


Leu Glu Met Arg Asp Tyr Ser Asn Lys Tyr Gly Tyr Ala Pro Ala Ser 
        115                 120                 125             


Ser Ser Val Ile Asp Gly Ala Ile Ile Glu Asp Ser Val Arg His Arg 
    130                 135                 140                 


Leu Met Ile Val Ile Asp Leu Trp Ala Trp Asn Gly Gly Val Phe Glu 
145                 150                 155                 160 


His Leu Asn Val Ser Pro Asp Gly Pro Val Asn Gly Gly Arg Pro Arg 
                165                 170                 175     


Lys Phe Pro Leu Gly Asp Gly Phe Ala Thr Val Ala Gly Arg Asp Met 
            180                 185                 190         


Leu Leu Leu Ser Thr His Asn Val Thr Gly Asp Ala Asp Gly Leu Arg 
        195                 200                 205             


Gly Asn Ile Asn Leu Asn Ile Asp Arg Ser Gln Phe Asp Leu Val Ala 
    210                 215                 220                 


Asp Leu Asp Gly Pro Arg Asp Lys His Gly Arg Ile Gln Ile Tyr Glu 
225                 230                 235                 240 


Leu Ile Gly Ile Pro Arg Pro Tyr Thr Thr Ala Gly Val Asp Asp Ser 
                245                 250                 255     


Asn Leu Ala Leu Gly Arg Arg Ser Arg Tyr Ser Leu Asp Asp Gly Phe 
            260                 265                 270         


Asn Leu Phe Glu Ala Gly Ile Pro Leu Tyr Val Phe Gln His Gly Ser 
        275                 280                 285             


Ala Arg Ile Thr Pro Met Arg Val Phe Tyr Lys Asp Ser Ile Leu Gln 
    290                 295                 300                 


Val Phe Asn Thr Asn His Ile Val Glu Ile Tyr Ser Tyr Asp Asp Gly 
305                 310                 315                 320 


Arg Thr Trp Asn Met Gly Lys Leu Val Thr Arg Gln Phe Arg Pro Val 
                325                 330                 335     


Asp Ser Arg Tyr Thr Leu Val Ala Pro Gly Arg Ser Ile Gln Ile Arg 
            340                 345                 350         


Ala Gly Glu His Ala Gly Arg Ile Val Val Pro Thr Tyr Met Met Leu 
        355                 360                 365             


Pro Ala Gly Ile Ser Cys Thr Thr Val Tyr Thr Asp Asp Gly Gly Glu 
    370                 375                 380                 


Thr Trp Gln Arg Gly Thr Pro Met Pro Ala Thr Ile Asp Leu His Glu 
385                 390                 395                 400 


Ser Ala Ile Thr Glu Val Leu Pro Gly Val Leu Arg Ser Phe Asn Arg 
                405                 410                 415     


His Ser Ala Ser Ser Gly Gly Lys Val Leu Thr Ala Glu Ser Val Asp 
            420                 425                 430         


Gly Gly His Ser Trp Ser Thr Leu Thr Ser Ala Phe Gly Asp Asp Asp 
        435                 440                 445             


Gln Gly Val Ala Cys Gln Val Ser Ala Leu Met Leu Lys Gln Thr Ile 
    450                 455                 460                 


Ala Ser Pro Thr Thr Gly Glu Gln Leu Pro Ala Leu Ile Val Val Ser 
465                 470                 475                 480 


Ala Asp Asp Arg Arg Arg Arg His Gly Ile Ala His Val Ala Val Val 
                485                 490                 495     


His Arg Ser Ser Arg Thr Phe Gly Pro Arg Ser Glu Leu Glu Trp Val 
            500                 505                 510         


Ser His Ala Asp Ile Thr Ser Pro Gln Thr Leu Phe Ala Tyr Ser Ser 
        515                 520                 525             


Ile Ala Gln Leu Ser Asp Gly Arg Val Leu Val Leu Phe Glu Ser Ser 
    530                 535                 540                 


Pro Thr Asp Ser Trp Ala Asp Gly Leu Gln Arg Met Tyr Leu Gln Glu 
545                 550                 555                 560 


Leu Ala Ser 
            


<210>  16
<211>  3966
<212>  DNA
<213>  Propionibacterium acnes


<220>
<221>  CDS
<222>  (1)..(3966)

<400>  16
atg tcg cga aca cca cgg ggc agg tcc atc ggt gcg ctc gcc gtg tca         48
Met Ser Arg Thr Pro Arg Gly Arg Ser Ile Gly Ala Leu Ala Val Ser           
1               5                   10                  15                

gct ggc acg atg ctg gca ctg atc gcg ccg acg gcc cct gca cat gcc         96
Ala Gly Thr Met Leu Ala Leu Ile Ala Pro Thr Ala Pro Ala His Ala           
            20                  25                  30                    

gag acc cgg tac cgc cag att aac cag gca gca atc acc gcg gtt gcc        144
Glu Thr Arg Tyr Arg Gln Ile Asn Gln Ala Ala Ile Thr Ala Val Ala           
        35                  40                  45                        

gct gat tca gcc acc gcc acc gat ccg atc tcc aac act ctg gac ggc        192
Ala Asp Ser Ala Thr Ala Thr Asp Pro Ile Ser Asn Thr Leu Asp Gly           
    50                  55                  60                            

aat ccc gac acg atc tgg cac acc aca tgg cag aac gga aag gac ccg        240
Asn Pro Asp Thr Ile Trp His Thr Thr Trp Gln Asn Gly Lys Asp Pro           
65                  70                  75                  80            

cta cct cac tgg atc gta ttc aaa cta ggt gat gag gcc gtg aac ctg        288
Leu Pro His Trp Ile Val Phe Lys Leu Gly Asp Glu Ala Val Asn Leu           
                85                  90                  95                

ggc aag gtg gaa atc aca ccc aga tcc agc tcg aac ggc tcg ggt cgc        336
Gly Lys Val Glu Ile Thr Pro Arg Ser Ser Ser Asn Gly Ser Gly Arg           
            100                 105                 110                   

atg cac gac tac gag cta tac acg gcc aac acc aag acc tgc aac aac        384
Met His Asp Tyr Glu Leu Tyr Thr Ala Asn Thr Lys Thr Cys Asn Asn           
        115                 120                 125                       

gcc gca ttc tcc tca gcg aag ccg gtt gca acg ggt tct tac gga gcc        432
Ala Ala Phe Ser Ser Ala Lys Pro Val Ala Thr Gly Ser Tyr Gly Ala           
    130                 135                 140                           

tcc gac acg tcg ata cgc aag atc acc ttc gcc gca acc aag gcc acc        480
Ser Asp Thr Ser Ile Arg Lys Ile Thr Phe Ala Ala Thr Lys Ala Thr           
145                 150                 155                 160           

tgc gtc aaa gtg aag gtg aac tcc tct tgg gga ggc gac gga tcg gac        528
Cys Val Lys Val Lys Val Asn Ser Ser Trp Gly Gly Asp Gly Ser Asp           
                165                 170                 175               

gag gaa gtc tcc tcg atg gcg gaa ttc aat gcc ttc acc gtc gac gga        576
Glu Glu Val Ser Ser Met Ala Glu Phe Asn Ala Phe Thr Val Asp Gly           
            180                 185                 190                   

tcg gac cct tct ccg gat ccc aca cca tcg gaa ccg ccg acc cca gag        624
Ser Asp Pro Ser Pro Asp Pro Thr Pro Ser Glu Pro Pro Thr Pro Glu           
        195                 200                 205                       

gtc ccg aaa gac gcc atc agc ctg tcc gac ggc act gtg acg gtc agg        672
Val Pro Lys Asp Ala Ile Ser Leu Ser Asp Gly Thr Val Thr Val Arg           
    210                 215                 220                           

gcc cgt cgt gac ttc ccg caa gtg atc gac tac acc gtc ggc cac gca        720
Ala Arg Arg Asp Phe Pro Gln Val Ile Asp Tyr Thr Val Gly His Ala           
225                 230                 235                 240           

cac atg gca gga cgt atc ggc tcc ccg ttg acg aag gtc agg atc aac        768
His Met Ala Gly Arg Ile Gly Ser Pro Leu Thr Lys Val Arg Ile Asn           
                245                 250                 255               

ggc gcc gac cac gtc gcc act gtg tcc gcg ccc acg acg act ggc tcc        816
Gly Ala Asp His Val Ala Thr Val Ser Ala Pro Thr Thr Thr Gly Ser           
            260                 265                 270                   

tcc gcg tcc tgg aag ctc acc ttc cgc gac ctg ccc ggc gtc gag ctc        864
Ser Ala Ser Trp Lys Leu Thr Phe Arg Asp Leu Pro Gly Val Glu Leu           
        275                 280                 285                       

act gca gac atc aag gtc tcc gat ggt gtc atg aca tgg tcg atc cca        912
Thr Ala Asp Ile Lys Val Ser Asp Gly Val Met Thr Trp Ser Ile Pro           
    290                 295                 300                           

cac atc gtc gac acc cct gac cac cgt gtc aac acc gtg tca gtg ccc        960
His Ile Val Asp Thr Pro Asp His Arg Val Asn Thr Val Ser Val Pro           
305                 310                 315                 320           

ggc ctc act ctc gcc tcg gtc acc tcg act gat ccg aaa gcc cag ctg       1008
Gly Leu Thr Leu Ala Ser Val Thr Ser Thr Asp Pro Lys Ala Gln Leu           
                325                 330                 335               

agc agc gca aac att gtc gtc gat cgc aac aag acc ggc gac ctc ttc       1056
Ser Ser Ala Asn Ile Val Val Asp Arg Asn Lys Thr Gly Asp Leu Phe           
            340                 345                 350                   

cag ccc ctc gcc acc gct gac gtc tcg cag gac acc tcc tgg gtc gcc       1104
Gln Pro Leu Ala Thr Ala Asp Val Ser Gln Asp Thr Ser Trp Val Ala           
        355                 360                 365                       

atg gcg aac gat tcc acg ctg gca gcc ggg ttc gag gac aac gca acc       1152
Met Ala Asn Asp Ser Thr Leu Ala Ala Gly Phe Glu Asp Asn Ala Thr           
    370                 375                 380                           

cag gac ggc ctg gtc ggc tcc gcc gcc acg gtt gcc cgt ttc gtc cac       1200
Gln Asp Gly Leu Val Gly Ser Ala Ala Thr Val Ala Arg Phe Val His           
385                 390                 395                 400           

tcc atc tcc cag gtt ggg ggg act aag gtc gga gcc atc gaa ccg gca       1248
Ser Ile Ser Gln Val Gly Gly Thr Lys Val Gly Ala Ile Glu Pro Ala           
                405                 410                 415               

acc tgg gtc cat cgt ggc aag ggg tcc gcc acc ccc ttc ccc acc gac       1296
Thr Trp Val His Arg Gly Lys Gly Ser Ala Thr Pro Phe Pro Thr Asp           
            420                 425                 430                   

tca ctc ggc aac aag gcc gta tgc cag ctg ccc ggt ggt gcc act gtc       1344
Ser Leu Gly Asn Lys Ala Val Cys Gln Leu Pro Gly Gly Ala Thr Val           
        435                 440                 445                       

aag gac ggc atc ggc cca gac ccc gac acc ccg tac gtc cgg gtg aag       1392
Lys Asp Gly Ile Gly Pro Asp Pro Asp Thr Pro Tyr Val Arg Val Lys           
    450                 455                 460                           

atc gtc gct gac gcc aat gcc gac ggc aag gtc gac tgg cag gac gca       1440
Ile Val Ala Asp Ala Asn Ala Asp Gly Lys Val Asp Trp Gln Asp Ala           
465                 470                 475                 480           

gcc gtc gcc acc cgg gac gtc acc atg aag ccg acc ggc tcg ggg gac       1488
Ala Val Ala Thr Arg Asp Val Thr Met Lys Pro Thr Gly Ser Gly Asp           
                485                 490                 495               

gtg gcg aac aag gtc atc acc cat att ccg ttt aac atc gtc tcc cag       1536
Val Ala Asn Lys Val Ile Thr His Ile Pro Phe Asn Ile Val Ser Gln           
            500                 505                 510                   

gcg act cat ccg ttc ctt cgt acc ttg gac gat gtc aag cgc atc tct       1584
Ala Thr His Pro Phe Leu Arg Thr Leu Asp Asp Val Lys Arg Ile Ser           
        515                 520                 525                       

ttg gcg acc gac ggg ctc ggc cag cag gcc ctg ctc aag ggc tac cag       1632
Leu Ala Thr Asp Gly Leu Gly Gln Gln Ala Leu Leu Lys Gly Tyr Gln           
    530                 535                 540                           

gcc gag ggc cac gac tcc gca cac ccc gac tac ggc ggc aac gtc tcc       1680
Ala Glu Gly His Asp Ser Ala His Pro Asp Tyr Gly Gly Asn Val Ser           
545                 550                 555                 560           

cac cgt gcc ggc ggg atg aag gat ctc gag aag ctc acc gag tcg ggc       1728
His Arg Ala Gly Gly Met Lys Asp Leu Glu Lys Leu Thr Glu Ser Gly           
                565                 570                 575               

agg cag tgg aac acc gat ttc ggc att cac gtc aac ctg gtg gag tct       1776
Arg Gln Trp Asn Thr Asp Phe Gly Ile His Val Asn Leu Val Glu Ser           
            580                 585                 590                   

tac cct gag gcg aat cac ttc ggc gac aac atc ctc gtt aag ccg tac       1824
Tyr Pro Glu Ala Asn His Phe Gly Asp Asn Ile Leu Val Lys Pro Tyr           
        595                 600                 605                       

cag aag gcg tgg gac tgg atg gag cag tcc tac cgg atg gac tac gcc       1872
Gln Lys Ala Trp Asp Trp Met Glu Gln Ser Tyr Arg Met Asp Tyr Ala           
    610                 615                 620                           

aag gac ctt ggg tct ggt cag ctc ttc gct cga ctc aac cag ctg agg       1920
Lys Asp Leu Gly Ser Gly Gln Leu Phe Ala Arg Leu Asn Gln Leu Arg           
625                 630                 635                 640           

aag gag ttg gga gcc aag tcc aac ctc gac tgg ttg tac ttc gac acc       1968
Lys Glu Leu Gly Ala Lys Ser Asn Leu Asp Trp Leu Tyr Phe Asp Thr           
                645                 650                 655               

aac tac cct gct ggt tgg cag aac gac cgg atc gcc aac gct ctg aac       2016
Asn Tyr Pro Ala Gly Trp Gln Asn Asp Arg Ile Ala Asn Ala Leu Asn           
            660                 665                 670                   

gcc gaa ggc tgg agg atc ggt tcc gaa tgg tcg tca acc tat ccg cgc       2064
Ala Glu Gly Trp Arg Ile Gly Ser Glu Trp Ser Ser Thr Tyr Pro Arg           
        675                 680                 685                       

tat aac cag tgg tcg cac tgg gcc aat gac gag aac tac gga acc gga       2112
Tyr Asn Gln Trp Ser His Trp Ala Asn Asp Glu Asn Tyr Gly Thr Gly           
    690                 695                 700                           

aac aag gga tac agt tcc cgg atc att cgg ttc atc gac aac tcc cgc       2160
Asn Lys Gly Tyr Ser Ser Arg Ile Ile Arg Phe Ile Asp Asn Ser Arg           
705                 710                 715                 720           

cgc gac act tgg aat cct gat ccg atc ctc ggc aac tcc aat gtc gtc       2208
Arg Asp Thr Trp Asn Pro Asp Pro Ile Leu Gly Asn Ser Asn Val Val           
                725                 730                 735               

gag tat gag ggt tgg acg agc cac aac gac tac aac gcg ttc atc gcg       2256
Glu Tyr Glu Gly Trp Thr Ser His Asn Asp Tyr Asn Ala Phe Ile Ala           
            740                 745                 750                   

aat gtg tgg cag cgc aac ctg cct acc aag ttc tta cag cgt tcg gac       2304
Asn Val Trp Gln Arg Asn Leu Pro Thr Lys Phe Leu Gln Arg Ser Asp           
        755                 760                 765                       

atc atg tct tgg caa gac ggc cgt atc gct ttc gct aac gga gcc gtg       2352
Ile Met Ser Trp Gln Asp Gly Arg Ile Ala Phe Ala Asn Gly Ala Val           
    770                 775                 780                           

gca act tcg tcg aag aag tcc atc tcg ggt cat gag att ccc acc gca       2400
Ala Thr Ser Ser Lys Lys Ser Ile Ser Gly His Glu Ile Pro Thr Ala           
785                 790                 795                 800           

aga acc atc acc ttt gac ggt gcc acg gtc ttc aag gaa ggc ggg tcc       2448
Arg Thr Ile Thr Phe Asp Gly Ala Thr Val Phe Lys Glu Gly Gly Ser           
                805                 810                 815               

tac ctg ctc cca tgg tct aac ggt ggc agc gat cgc ctg tac tac tgg       2496
Tyr Leu Leu Pro Trp Ser Asn Gly Gly Ser Asp Arg Leu Tyr Tyr Trp           
            820                 825                 830                   

aat ccg ggc aat ggc tca gca act tgg aaa ctc acg aat tcc tgg gcg       2544
Asn Pro Gly Asn Gly Ser Ala Thr Trp Lys Leu Thr Asn Ser Trp Ala           
        835                 840                 845                       

gca cag aaa tcg gta tct ctg ttc atg ctc acc gac acc ggc cgt gtc       2592
Ala Gln Lys Ser Val Ser Leu Phe Met Leu Thr Asp Thr Gly Arg Val           
    850                 855                 860                           

aag gtt gcc gaa atc ccc gtc acc aac agg tcc atc agg att ccc gca       2640
Lys Val Ala Glu Ile Pro Val Thr Asn Arg Ser Ile Arg Ile Pro Ala           
865                 870                 875                 880           

acc aag gcc aag act gcc tac gtc ctc tac ccg acg tct aag gtg cct       2688
Thr Lys Ala Lys Thr Ala Tyr Val Leu Tyr Pro Thr Ser Lys Val Pro           
                885                 890                 895               

gct gca aaa acc ccg aac tgg gga gag gga agt cac ttc gcc aat ccg       2736
Ala Ala Lys Thr Pro Asn Trp Gly Glu Gly Ser His Phe Ala Asn Pro           
            900                 905                 910                   

ggc ttc tac tcc ggt gac acc gct ggt tgg aat gcc cgg gga aac gtc       2784
Gly Phe Tyr Ser Gly Asp Thr Ala Gly Trp Asn Ala Arg Gly Asn Val           
        915                 920                 925                       

tcg gtc aag cac aac gac cgt ggc aac ttc cac ctc gag ttc ggc aag       2832
Ser Val Lys His Asn Asp Arg Gly Asn Phe His Leu Glu Phe Gly Lys           
    930                 935                 940                           

gca cag tcg cag atc tcc caa gtc ctc aat ctg cct gct ggt gac cac       2880
Ala Gln Ser Gln Ile Ser Gln Val Leu Asn Leu Pro Ala Gly Asp His           
945                 950                 955                 960           

tcc ctg tgg gcg tgg gtc cag ata gat ccg act aag acc cgt cca gtg       2928
Ser Leu Trp Ala Trp Val Gln Ile Asp Pro Thr Lys Thr Arg Pro Val           
                965                 970                 975               

gga ctt gcc gtc gac ggc acc ggg gtc act ccc atc gac cat cag aag       2976
Gly Leu Ala Val Asp Gly Thr Gly Val Thr Pro Ile Asp His Gln Lys           
            980                 985                 990                   

gga tgc ggg ggc cac gcg gaa tcc  gtc atc acg tcc acg  aca gcc atc     3024
Gly Cys Gly Gly His Ala Glu Ser  Val Ile Thr Ser Thr  Thr Ala Ile         
        995                 1000                 1005                     

aac gcc  acc gct tcc gac gag  tat ttc ggc acc tac  cac cag cgg        3069
Asn Ala  Thr Ala Ser Asp Glu  Tyr Phe Gly Thr Tyr  His Gln Arg            
    1010                 1015                 1020                        

ctg cga  gtt gct ttc cac tct  gac ggc aga cca gtc  acc gtt acc        3114
Leu Arg  Val Ala Phe His Ser  Asp Gly Arg Pro Val  Thr Val Thr            
    1025                 1030                 1035                        

ttg aag  gcg ctc gcc ggg aat  gct atc gtc agc gcc  gat gac ttc        3159
Leu Lys  Ala Leu Ala Gly Asn  Ala Ile Val Ser Ala  Asp Asp Phe            
    1040                 1045                 1050                        

cga gtc  gtt gac gct gct gtg  ccc agc gac cct cac  gtc acg cct        3204
Arg Val  Val Asp Ala Ala Val  Pro Ser Asp Pro His  Val Thr Pro            
    1055                 1060                 1065                        

gcg acc  gtt ctt ttc cag aac  ttc gag gac gtc gac  acc ggt tac        3249
Ala Thr  Val Leu Phe Gln Asn  Phe Glu Asp Val Asp  Thr Gly Tyr            
    1070                 1075                 1080                        

tgg ccc  ttc gtc acg gga agc  gca ggc atg gag gga  gat gcc cgg        3294
Trp Pro  Phe Val Thr Gly Ser  Ala Gly Met Glu Gly  Asp Ala Arg            
    1085                 1090                 1095                        

acc cag  tta tcc cgt cgc cat  gag cct tac acc cag  aaa ggt tgg        3339
Thr Gln  Leu Ser Arg Arg His  Glu Pro Tyr Thr Gln  Lys Gly Trp            
    1100                 1105                 1110                        

aac ggt  cgg gcc atg gac tcg  gtt ctc agc ggt gac  tgg tcc ttg        3384
Asn Gly  Arg Ala Met Asp Ser  Val Leu Ser Gly Asp  Trp Ser Leu            
    1115                 1120                 1125                        

aag atg  cac gaa gaa cgc aac  ggg atc gtg ctg cgc  acg acc acc        3429
Lys Met  His Glu Glu Arg Asn  Gly Ile Val Leu Arg  Thr Thr Thr            
    1130                 1135                 1140                        

gcg tcc  gcc cct ctg acc ggg  ggc gga acc cgg tac  cgc atc tcc        3474
Ala Ser  Ala Pro Leu Thr Gly  Gly Gly Thr Arg Tyr  Arg Ile Ser            
    1145                 1150                 1155                        

ttc gac  tac cag gct gac aaa  ccc ggg tac tcg ttc  gtc aca ggt        3519
Phe Asp  Tyr Gln Ala Asp Lys  Pro Gly Tyr Ser Phe  Val Thr Gly            
    1160                 1165                 1170                        

cac gac  aag gtc agc gga aag  tcc gtc aag gaa gtc  atc acc gag        3564
His Asp  Lys Val Ser Gly Lys  Ser Val Lys Glu Val  Ile Thr Glu            
    1175                 1180                 1185                        

tcc cat  gcc atg gga gtc gcc  acc tcg acg act cat  ttc tcc acc        3609
Ser His  Ala Met Gly Val Ala  Thr Ser Thr Thr His  Phe Ser Thr            
    1190                 1195                 1200                        

gac atc  gtt gtg aag gac caa  cct gcc tgg atc gga  ttc acc cac        3654
Asp Ile  Val Val Lys Asp Gln  Pro Ala Trp Ile Gly  Phe Thr His            
    1205                 1210                 1215                        

cag ggt  gaa ggg gat atg tcc  atc gac aac ctg cgc  atc gaa aag        3699
Gln Gly  Glu Gly Asp Met Ser  Ile Asp Asn Leu Arg  Ile Glu Lys            
    1220                 1225                 1230                        

ctc gat  cca cga ccg atc tcc  gtc acc tcc acg cag  gca gcg gtg        3744
Leu Asp  Pro Arg Pro Ile Ser  Val Thr Ser Thr Gln  Ala Ala Val            
    1235                 1240                 1245                        

ttc ccg  gat gcc tgc aag ccg  acc ccc gaa ccg atc  caa ccg gcg        3789
Phe Pro  Asp Ala Cys Lys Pro  Thr Pro Glu Pro Ile  Gln Pro Ala            
    1250                 1255                 1260                        

caa ccc  tcg gct tcc gct ccg  acg aca tcc ggc tcc  ccc caa gcc        3834
Gln Pro  Ser Ala Ser Ala Pro  Thr Thr Ser Gly Ser  Pro Gln Ala            
    1265                 1270                 1275                        

cct gga  acc ggt aac cgc ccc  aac cgt tat gcc ttg  cct cgt acc        3879
Pro Gly  Thr Gly Asn Arg Pro  Asn Arg Tyr Ala Leu  Pro Arg Thr            
    1280                 1285                 1290                        

gga gca  gac ggc gcc ggg ctc  ggc ttc agc agt tcc  gag gcg gca        3924
Gly Ala  Asp Gly Ala Gly Leu  Gly Phe Ser Ser Ser  Glu Ala Ala            
    1295                 1300                 1305                        

tcg gca  aca gct gct gtg ggt  gtc tcc cgt caa ggc  cga tga            3966
Ser Ala  Thr Ala Ala Val Gly  Val Ser Arg Gln Gly  Arg                    
    1310                 1315                 1320                        


<210>  17
<211>  1321
<212>  PRT
<213>  Propionibacterium acnes

<400>  17

Met Ser Arg Thr Pro Arg Gly Arg Ser Ile Gly Ala Leu Ala Val Ser 
1               5                   10                  15      


Ala Gly Thr Met Leu Ala Leu Ile Ala Pro Thr Ala Pro Ala His Ala 
            20                  25                  30          


Glu Thr Arg Tyr Arg Gln Ile Asn Gln Ala Ala Ile Thr Ala Val Ala 
        35                  40                  45              


Ala Asp Ser Ala Thr Ala Thr Asp Pro Ile Ser Asn Thr Leu Asp Gly 
    50                  55                  60                  


Asn Pro Asp Thr Ile Trp His Thr Thr Trp Gln Asn Gly Lys Asp Pro 
65                  70                  75                  80  


Leu Pro His Trp Ile Val Phe Lys Leu Gly Asp Glu Ala Val Asn Leu 
                85                  90                  95      


Gly Lys Val Glu Ile Thr Pro Arg Ser Ser Ser Asn Gly Ser Gly Arg 
            100                 105                 110         


Met His Asp Tyr Glu Leu Tyr Thr Ala Asn Thr Lys Thr Cys Asn Asn 
        115                 120                 125             


Ala Ala Phe Ser Ser Ala Lys Pro Val Ala Thr Gly Ser Tyr Gly Ala 
    130                 135                 140                 


Ser Asp Thr Ser Ile Arg Lys Ile Thr Phe Ala Ala Thr Lys Ala Thr 
145                 150                 155                 160 


Cys Val Lys Val Lys Val Asn Ser Ser Trp Gly Gly Asp Gly Ser Asp 
                165                 170                 175     


Glu Glu Val Ser Ser Met Ala Glu Phe Asn Ala Phe Thr Val Asp Gly 
            180                 185                 190         


Ser Asp Pro Ser Pro Asp Pro Thr Pro Ser Glu Pro Pro Thr Pro Glu 
        195                 200                 205             


Val Pro Lys Asp Ala Ile Ser Leu Ser Asp Gly Thr Val Thr Val Arg 
    210                 215                 220                 


Ala Arg Arg Asp Phe Pro Gln Val Ile Asp Tyr Thr Val Gly His Ala 
225                 230                 235                 240 


His Met Ala Gly Arg Ile Gly Ser Pro Leu Thr Lys Val Arg Ile Asn 
                245                 250                 255     


Gly Ala Asp His Val Ala Thr Val Ser Ala Pro Thr Thr Thr Gly Ser 
            260                 265                 270         


Ser Ala Ser Trp Lys Leu Thr Phe Arg Asp Leu Pro Gly Val Glu Leu 
        275                 280                 285             


Thr Ala Asp Ile Lys Val Ser Asp Gly Val Met Thr Trp Ser Ile Pro 
    290                 295                 300                 


His Ile Val Asp Thr Pro Asp His Arg Val Asn Thr Val Ser Val Pro 
305                 310                 315                 320 


Gly Leu Thr Leu Ala Ser Val Thr Ser Thr Asp Pro Lys Ala Gln Leu 
                325                 330                 335     


Ser Ser Ala Asn Ile Val Val Asp Arg Asn Lys Thr Gly Asp Leu Phe 
            340                 345                 350         


Gln Pro Leu Ala Thr Ala Asp Val Ser Gln Asp Thr Ser Trp Val Ala 
        355                 360                 365             


Met Ala Asn Asp Ser Thr Leu Ala Ala Gly Phe Glu Asp Asn Ala Thr 
    370                 375                 380                 


Gln Asp Gly Leu Val Gly Ser Ala Ala Thr Val Ala Arg Phe Val His 
385                 390                 395                 400 


Ser Ile Ser Gln Val Gly Gly Thr Lys Val Gly Ala Ile Glu Pro Ala 
                405                 410                 415     


Thr Trp Val His Arg Gly Lys Gly Ser Ala Thr Pro Phe Pro Thr Asp 
            420                 425                 430         


Ser Leu Gly Asn Lys Ala Val Cys Gln Leu Pro Gly Gly Ala Thr Val 
        435                 440                 445             


Lys Asp Gly Ile Gly Pro Asp Pro Asp Thr Pro Tyr Val Arg Val Lys 
    450                 455                 460                 


Ile Val Ala Asp Ala Asn Ala Asp Gly Lys Val Asp Trp Gln Asp Ala 
465                 470                 475                 480 


Ala Val Ala Thr Arg Asp Val Thr Met Lys Pro Thr Gly Ser Gly Asp 
                485                 490                 495     


Val Ala Asn Lys Val Ile Thr His Ile Pro Phe Asn Ile Val Ser Gln 
            500                 505                 510         


Ala Thr His Pro Phe Leu Arg Thr Leu Asp Asp Val Lys Arg Ile Ser 
        515                 520                 525             


Leu Ala Thr Asp Gly Leu Gly Gln Gln Ala Leu Leu Lys Gly Tyr Gln 
    530                 535                 540                 


Ala Glu Gly His Asp Ser Ala His Pro Asp Tyr Gly Gly Asn Val Ser 
545                 550                 555                 560 


His Arg Ala Gly Gly Met Lys Asp Leu Glu Lys Leu Thr Glu Ser Gly 
                565                 570                 575     


Arg Gln Trp Asn Thr Asp Phe Gly Ile His Val Asn Leu Val Glu Ser 
            580                 585                 590         


Tyr Pro Glu Ala Asn His Phe Gly Asp Asn Ile Leu Val Lys Pro Tyr 
        595                 600                 605             


Gln Lys Ala Trp Asp Trp Met Glu Gln Ser Tyr Arg Met Asp Tyr Ala 
    610                 615                 620                 


Lys Asp Leu Gly Ser Gly Gln Leu Phe Ala Arg Leu Asn Gln Leu Arg 
625                 630                 635                 640 


Lys Glu Leu Gly Ala Lys Ser Asn Leu Asp Trp Leu Tyr Phe Asp Thr 
                645                 650                 655     


Asn Tyr Pro Ala Gly Trp Gln Asn Asp Arg Ile Ala Asn Ala Leu Asn 
            660                 665                 670         


Ala Glu Gly Trp Arg Ile Gly Ser Glu Trp Ser Ser Thr Tyr Pro Arg 
        675                 680                 685             


Tyr Asn Gln Trp Ser His Trp Ala Asn Asp Glu Asn Tyr Gly Thr Gly 
    690                 695                 700                 


Asn Lys Gly Tyr Ser Ser Arg Ile Ile Arg Phe Ile Asp Asn Ser Arg 
705                 710                 715                 720 


Arg Asp Thr Trp Asn Pro Asp Pro Ile Leu Gly Asn Ser Asn Val Val 
                725                 730                 735     


Glu Tyr Glu Gly Trp Thr Ser His Asn Asp Tyr Asn Ala Phe Ile Ala 
            740                 745                 750         


Asn Val Trp Gln Arg Asn Leu Pro Thr Lys Phe Leu Gln Arg Ser Asp 
        755                 760                 765             


Ile Met Ser Trp Gln Asp Gly Arg Ile Ala Phe Ala Asn Gly Ala Val 
    770                 775                 780                 


Ala Thr Ser Ser Lys Lys Ser Ile Ser Gly His Glu Ile Pro Thr Ala 
785                 790                 795                 800 


Arg Thr Ile Thr Phe Asp Gly Ala Thr Val Phe Lys Glu Gly Gly Ser 
                805                 810                 815     


Tyr Leu Leu Pro Trp Ser Asn Gly Gly Ser Asp Arg Leu Tyr Tyr Trp 
            820                 825                 830         


Asn Pro Gly Asn Gly Ser Ala Thr Trp Lys Leu Thr Asn Ser Trp Ala 
        835                 840                 845             


Ala Gln Lys Ser Val Ser Leu Phe Met Leu Thr Asp Thr Gly Arg Val 
    850                 855                 860                 


Lys Val Ala Glu Ile Pro Val Thr Asn Arg Ser Ile Arg Ile Pro Ala 
865                 870                 875                 880 


Thr Lys Ala Lys Thr Ala Tyr Val Leu Tyr Pro Thr Ser Lys Val Pro 
                885                 890                 895     


Ala Ala Lys Thr Pro Asn Trp Gly Glu Gly Ser His Phe Ala Asn Pro 
            900                 905                 910         


Gly Phe Tyr Ser Gly Asp Thr Ala Gly Trp Asn Ala Arg Gly Asn Val 
        915                 920                 925             


Ser Val Lys His Asn Asp Arg Gly Asn Phe His Leu Glu Phe Gly Lys 
    930                 935                 940                 


Ala Gln Ser Gln Ile Ser Gln Val Leu Asn Leu Pro Ala Gly Asp His 
945                 950                 955                 960 


Ser Leu Trp Ala Trp Val Gln Ile Asp Pro Thr Lys Thr Arg Pro Val 
                965                 970                 975     


Gly Leu Ala Val Asp Gly Thr Gly Val Thr Pro Ile Asp His Gln Lys 
            980                 985                 990         


Gly Cys Gly Gly His Ala Glu Ser  Val Ile Thr Ser Thr  Thr Ala Ile 
        995                 1000                 1005             


Asn Ala  Thr Ala Ser Asp Glu  Tyr Phe Gly Thr Tyr  His Gln Arg 
    1010                 1015                 1020             


Leu Arg  Val Ala Phe His Ser  Asp Gly Arg Pro Val  Thr Val Thr 
    1025                 1030                 1035             


Leu Lys  Ala Leu Ala Gly Asn  Ala Ile Val Ser Ala  Asp Asp Phe 
    1040                 1045                 1050             


Arg Val  Val Asp Ala Ala Val  Pro Ser Asp Pro His  Val Thr Pro 
    1055                 1060                 1065             


Ala Thr  Val Leu Phe Gln Asn  Phe Glu Asp Val Asp  Thr Gly Tyr 
    1070                 1075                 1080             


Trp Pro  Phe Val Thr Gly Ser  Ala Gly Met Glu Gly  Asp Ala Arg 
    1085                 1090                 1095             


Thr Gln  Leu Ser Arg Arg His  Glu Pro Tyr Thr Gln  Lys Gly Trp 
    1100                 1105                 1110             


Asn Gly  Arg Ala Met Asp Ser  Val Leu Ser Gly Asp  Trp Ser Leu 
    1115                 1120                 1125             


Lys Met  His Glu Glu Arg Asn  Gly Ile Val Leu Arg  Thr Thr Thr 
    1130                 1135                 1140             


Ala Ser  Ala Pro Leu Thr Gly  Gly Gly Thr Arg Tyr  Arg Ile Ser 
    1145                 1150                 1155             


Phe Asp  Tyr Gln Ala Asp Lys  Pro Gly Tyr Ser Phe  Val Thr Gly 
    1160                 1165                 1170             


His Asp  Lys Val Ser Gly Lys  Ser Val Lys Glu Val  Ile Thr Glu 
    1175                 1180                 1185             


Ser His  Ala Met Gly Val Ala  Thr Ser Thr Thr His  Phe Ser Thr 
    1190                 1195                 1200             


Asp Ile  Val Val Lys Asp Gln  Pro Ala Trp Ile Gly  Phe Thr His 
    1205                 1210                 1215             


Gln Gly  Glu Gly Asp Met Ser  Ile Asp Asn Leu Arg  Ile Glu Lys 
    1220                 1225                 1230             


Leu Asp  Pro Arg Pro Ile Ser  Val Thr Ser Thr Gln  Ala Ala Val 
    1235                 1240                 1245             


Phe Pro  Asp Ala Cys Lys Pro  Thr Pro Glu Pro Ile  Gln Pro Ala 
    1250                 1255                 1260             


Gln Pro  Ser Ala Ser Ala Pro  Thr Thr Ser Gly Ser  Pro Gln Ala 
    1265                 1270                 1275             


Pro Gly  Thr Gly Asn Arg Pro  Asn Arg Tyr Ala Leu  Pro Arg Thr 
    1280                 1285                 1290             


Gly Ala  Asp Gly Ala Gly Leu  Gly Phe Ser Ser Ser  Glu Ala Ala 
    1295                 1300                 1305             


Ser Ala  Thr Ala Ala Val Gly  Val Ser Arg Gln Gly  Arg 
    1310                 1315                 1320     


<210>  18
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  18
ccttctagag gagatatacc atgggtcata atcat                                  35


<210>  19
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  19
tcccccgggt taattaatta agcggccgcc                                        30


<210>  20
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  20
agatctagaa tgtctggttc tcatcatcat catc                                   34


<210>  21
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  21
gcccccgggt tagccttcga tcccgaggtt                                        30


