SEQUENCE LISTING

<110>  Pierre Fabre Mdicament
       Goetsch, Liliane
       Wurch, Thierry
       Bes, Cdric
 
<120>  Novel anti-cMet antibody

<130>  D27117

<160>  55    

<170>  PatentIn version 3.3

<210>  1
<211>  8
<212>  PRT
<213>  mus musculus

<400>  1

Gly Tyr Ile Phe Thr Ala Tyr Thr 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  mus musculus

<400>  2

Ile Lys Pro Asn Asn Gly Leu Ala 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  mus musculus

<400>  3

Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr 
1               5                   10      


<210>  4
<211>  118
<212>  PRT
<213>  mus musculus

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  5
<211>  10
<212>  PRT
<213>  mus musculus

<400>  5

Glu Ser Val Asp Ser Tyr Ala Asn Ser Phe 
1               5                   10  


<210>  6
<211>  3
<212>  PRT
<213>  mus musculus

<400>  6

Arg Ala Ser 
1           


<210>  7
<211>  9
<212>  PRT
<213>  mus musculus

<400>  7

Gln Gln Ser Lys Glu Asp Pro Leu Thr 
1               5                   


<210>  8
<211>  112
<212>  PRT
<213>  mus musculus

<400>  8

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  9
<211>  112
<212>  PRT
<213>  mus musculus

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  10
<211>  112
<212>  PRT
<213>  mus musculus

<400>  10

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  11
<211>  24
<212>  DNA
<213>  mus musculus

<400>  11
ggctacatct tcacagcata cacc                                            24


<210>  12
<211>  24
<212>  DNA
<213>  mus musculus

<400>  12
attaaaccca acaatgggct ggcc                                            24


<210>  13
<211>  33
<212>  DNA
<213>  mus musculus

<400>  13
gccaggagcg aaattacaac agaattcgat tac                                  33


<210>  14
<211>  354
<212>  DNA
<213>  mus musculus

<400>  14
caggtccagc tggtgcaatc cggcgcagag gtgaagaagc caggcgcttc cgtgaaggtg     60

agctgtaagg cctctggcta catcttcaca gcatacacca tgcactgggt gaggcaagct    120

cctgggcagg gactggagtg gatgggatgg attaaaccca acaatgggct ggccaactac    180

gcccagaaat tccagggtag ggtcactatg acaagggata ccagcatcag caccgcatat    240

atggagctga gcaggctgag gtctgacgac actgctgtct attattgcgc caggagcgaa    300

attacaacag aattcgatta ctgggggcag ggcaccctgg tgaccgtgtc ctct          354


<210>  15
<211>  30
<212>  DNA
<213>  mus musculus

<400>  15
gaatctgtgg actcttacgc aaacagcttt                                      30


<210>  16
<211>  9
<212>  DNA
<213>  mus musculus

<400>  16
agggcttct                                                              9


<210>  17
<211>  27
<212>  DNA
<213>  mus musculus

<400>  17
cagcagtcca aggaggaccc cctgact                                         27


<210>  18
<211>  336
<212>  DNA
<213>  mus musculus

<400>  18
gacattgtgc tgacccagtc tcccgatagc ctggccgtgt ccctgggcga gagggctacc     60

atcaactgta aaagctccga atctgtggac tcttacgcaa acagctttat gcactggtat    120

cagcaaaagc caggccaacc tccaaagctg ctgatttaca gggcttctac cagggagagc    180

ggcgtgcccg ataggttcag cggatctggc agcaggaccg actttacact gaccatctcc    240

agcctgcagg ccgaagatgt ggcagtctat tactgccagc agtccaagga ggaccccctg    300

actttcgggg gtggtactaa agtggagatc aagcgt                              336


<210>  19
<211>  336
<212>  DNA
<213>  mus musculus

<400>  19
gacattgtga tgacccagtc tcccgatagc ctggccgtgt ccctgggcga gagggctacc     60

atcaactgta aaagctccga atctgtggac tcttacgcaa acagctttat gcactggtat    120

cagcaaaagc caggccaacc tccaaagctg ctgatttaca gggcttctac cagggagagc    180

ggcgtgcccg ataggttcag cggatctggc agcggcaccg actttacact gaccatctcc    240

agcctgcagg ccgaagatgt ggcagtctat tactgccagc agtccaagga ggaccccctg    300

actttcgggg gtggtactaa agtggagatc aagcgt                              336


<210>  20
<211>  336
<212>  DNA
<213>  mus musculus

<400>  20
gacattgtga tgacccagtc tcccgatagc ctggccgtgt ccctgggcga gagggctacc     60

atcaactgta aaagctccga atctgtggac tcttacgcaa acagctttct gcactggtat    120

cagcaaaagc caggccaacc tccaaagctg ctgatttaca gggcttctac cagggagagc    180

ggcgtgcccg ataggttcag cggatctggc agcggcaccg actttacact gaccatctcc    240

agcctgcagg ccgaagatgt ggcagtctat tactgccagc agtccaagga ggaccccctg    300

actttcgggg gtggtactaa agtggagatc aagcgt                              336


<210>  21
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus artificial hinge proteic sequence


<220>
<221>  MUTAGEN
<222>  (1)..(1)
<223>  Xaa is P or R

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa is K or R

<220>
<221>  MUTAGEN
<222>  (3)..(3)
<223>  Xaa is S, D or nothing

<220>
<221>  MUTAGEN
<222>  (5)..(5)
<223>  Xaa is G, D or nothing

<220>
<221>  MUTAGEN
<222>  (7)..(7)
<223>  Xaa is K, H or V

<220>
<221>  MUTAGEN
<222>  (8)..(8)
<223>  Xaa is E, P, T or nothing

<220>
<221>  MUTAGEN
<222>  (10)..(10)
<223>  Xaa is P or I

<220>
<221>  MUTAGEN
<222>  (11)..(11)
<223>  Xaa is P or nothing

<220>
<221>  MUTAGEN
<222>  (13)..(13)
<223>  Xaa is P or T

<400>  21

Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Cys Xaa Xaa Cys Xaa 
1               5                   10              


<210>  22
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG2

<400>  22

Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10      


<210>  23
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG1

<400>  23

Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
1               5                   10          


<210>  24
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG1

<400>  24

Pro Lys Ser Cys Gly Cys Lys Pro Cys Ile Cys Thr 
1               5                   10          


<210>  25
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG1

<400>  25

Pro Lys Ser Cys Gly Cys Lys Pro Cys Ile Cys Pro 
1               5                   10          


<210>  26
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG1

<400>  26

Pro Arg Asp Cys Gly Cys Lys Pro Cys Pro Pro Cys Pro 
1               5                   10              


<210>  27
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG1

<400>  27

Pro Arg Asp Cys Gly Cys His Thr Cys Pro Pro Cys Pro 
1               5                   10              


<210>  28
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG1

<400>  28

Pro Lys Ser Cys Asp Cys His Cys Pro Pro Cys Pro 
1               5                   10          


<210>  29
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG2

<400>  29
aggaagtgct gtgtggagtg ccccccctgc cca                                  33


<210>  30
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  artificial sequence derived from IgG1

<400>  30
ccccgggact gtgggtgcaa gccttgcatt tgtacc                               36


<210>  31
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG1

<400>  31
cccaagagct gtgggtgcaa gccttgcatt tgtacc                               36


<210>  32
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG1

<400>  32
ccaaagagct gcggctgcaa gccttgtatc tgtccc                               36


<210>  33
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG1

<400>  33
ccacgggact gtggctgcaa gccctgccct ccgtgtcca                            39


<210>  34
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG1

<400>  34
cccagagact gtgggtgtca cacctgccct ccttgtcct                            39


<210>  35
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  artificial hinge derived from IgG1

<400>  35
cccaaaagct gcgattgcca ctgtcctcca tgtcca                               36


<210>  36
<211>  443
<212>  PRT
<213>  mus musculus

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  37
<211>  445
<212>  PRT
<213>  mus musculus

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Cys His Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  38
<211>  218
<212>  PRT
<213>  mus musculus

<400>  38

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  39
<211>  218
<212>  PRT
<213>  mus musculus

<400>  39

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  40
<211>  218
<212>  PRT
<213>  mus musculus

<400>  40

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  41
<211>  1332
<212>  DNA
<213>  mus musculus

<400>  41
caggtccagc tggtgcaatc cggcgcagag gtgaagaagc caggcgcttc cgtgaaggtg     60

agctgtaagg cctctggcta catcttcaca gcatacacca tgcactgggt gaggcaagct    120

cctgggcagg gactggagtg gatgggatgg attaaaccca acaatgggct ggccaactac    180

gcccagaaat tccagggtag ggtcactatg acaagggata ccagcatcag caccgcatat    240

atggagctga gcaggctgag gtctgacgac actgctgtct attattgcgc caggagcgaa    300

attacaacag aattcgatta ctgggggcag ggcaccctgg tgaccgtgtc ctctgccagc    360

accaagggcc caagcgtgtt cccgctagcg ccctgctcca gaagcaccag cgagagcaca    420

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gtcctggaac    480

agcggagccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg    540

tacagcctga gcagcgtggt gaccgtgcca agcagcaact tcggcaccca gacctacacc    600

tgtaacgtgg accacaagcc cagcaacacc aaggtggaca agaccgtgga gaggaagtgc    660

tgtgtggagt gccccccctg cccagccccc ccagtggccg gacccagcgt gttcctgttc    720

ccccccaagc ccaaggacac cctgatgatc agcagaaccc ccgaggtgac ctgtgtggtg    780

gtggacgtgt cccacgagga ccccgaggtg cagttcaact ggtacgtgga cggcgtggag    840

gtgcacaacg ccaagaccaa gcccagagag gagcagttta acagcacctt ccgggtggtg    900

tccgtgctga ccgtggtgca ccaggactgg ctgaacggca aggagtacaa gtgtaaggtc    960

tccaacaagg gcctgccagc ccccatcgaa aagaccatca gcaagaccaa gggacagcca   1020

agagagccac aggtctacac cctgcccccc agcagggagg agatgaccaa gaaccaggtg   1080

tccctgacct gtctggtgaa gggcttctac ccaagcgaca tcgccgtgga gtgggagagc   1140

aacggccagc ccgagaacaa ctacaagacc acccccccaa tgctggacag cgacggcagc   1200

ttcttcctgt acagcaagct gacagtggac aagagcagat ggcagcaggg caacgtgttc   1260

agctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagag cctgagcctg   1320

tccccaggct ga                                                       1332


<210>  42
<211>  1341
<212>  DNA
<213>  mus musculus

<400>  42
caggtccagc tggtgcaatc cggcgcagag gtgaagaagc caggcgcttc cgtgaaggtg     60

agctgtaagg cctctggcta catcttcaca gcatacacca tgcactgggt gaggcaagct    120

cctgggcagg gactggagtg gatgggatgg attaaaccca acaatgggct ggccaactac    180

gcccagaaat tccagggtag ggtcactatg acaagggata ccagcatcag caccgcatat    240

atggagctga gcaggctgag gtctgacgac actgctgtct attattgcgc caggagcgaa    300

attacaacag aattcgatta ctgggggcag ggcaccctgg tgaccgtgtc ctctgccagc    360

accaagggcc caagcgtgtt cccgctagcc ccgtcttcaa agagtacctc aggcggaact    420

gccgctcttg gttgccttgt gaaggactat tttcctgagc ccgtgacggt cagctggaac    480

tctggcgcac tgactagcgg cgtacacaca ttccctgcgg tgctccaaag ttccgggctg    540

tactcactgt cctccgttgt gaccgttcca tctagttccc tcgggacaca gacatacatc    600

tgtaatgtga atcataagcc ttcaaacacc aaggtcgaca aacgggtcga gcccaaaagc    660

tgcgattgcc actgtcctcc atgtccagcc cccgaactgt tgggcggacc gagcgtgttc    720

ttgtttccac ccaagcccaa agataccctc atgatcagca gaacccccga ggtgacctgt    780

gtggtggtgg acgtgtccca cgaggaccca gaggtgaagt tcaactggta cgtggacggc    840

gtggaggtgc acaacgccaa gaccaagccc agagaggagc agtacaacag cacctacagg    900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgt    960

aaggtgtcca acaaggccct gccagcccca atcgaaaaga ccatcagcaa ggccaagggc   1020

cagccaagag agccccaggt gtacaccctg ccacccagca gggaggagat gaccaagaac   1080

caggtgtccc tgacctgtct ggtgaagggc ttctacccaa gcgacatcgc cgtggagtgg   1140

gagagcaacg gccagcccga gaacaactac aagaccaccc ccccagtgct ggacagcgac   1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac   1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcctg   1320

agcctgtccc caggcaagtg a                                             1341


<210>  43
<211>  657
<212>  DNA
<213>  mus musculus

<400>  43
gacattgtgc tgacccagtc tcccgatagc ctggccgtgt ccctgggcga gagggctacc     60

atcaactgta aaagctccga atctgtggac tcttacgcaa acagctttat gcactggtat    120

cagcaaaagc caggccaacc tccaaagctg ctgatttaca gggcttctac cagggagagc    180

ggcgtgcccg ataggttcag cggatctggc agcaggaccg actttacact gaccatctcc    240

agcctgcagg ccgaagatgt ggcagtctat tactgccagc agtccaagga ggaccccctg    300

actttcgggg gtggtactaa agtggagatc aagcgtacgg tggccgctcc cagcgtgttc    360

atcttccccc caagcgacga gcagctgaag agcggcaccg ccagcgtggt gtgtctgctg    420

aacaacttct accccaggga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc    480

ggcaacagcc aggagagcgt caccgagcag gacagcaagg actccaccta cagcctgagc    540

agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgtgaggtg    600

acccaccagg gcctgtccag ccccgtgacc aagagcttca acaggggcga gtgctga       657


<210>  44
<211>  657
<212>  DNA
<213>  mus musculus

<400>  44
gacattgtga tgacccagtc tcccgatagc ctggccgtgt ccctgggcga gagggctacc     60

atcaactgta aaagctccga atctgtggac tcttacgcaa acagctttat gcactggtat    120

cagcaaaagc caggccaacc tccaaagctg ctgatttaca gggcttctac cagggagagc    180

ggcgtgcccg ataggttcag cggatctggc agcggcaccg actttacact gaccatctcc    240

agcctgcagg ccgaagatgt ggcagtctat tactgccagc agtccaagga ggaccccctg    300

actttcgggg gtggtactaa agtggagatc aagcgtacgg tggccgctcc cagcgtgttc    360

atcttccccc caagcgacga gcagctgaag agcggcaccg ccagcgtggt gtgtctgctg    420

aacaacttct accccaggga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc    480

ggcaacagcc aggagagcgt caccgagcag gacagcaagg actccaccta cagcctgagc    540

agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgtgaggtg    600

acccaccagg gcctgtccag ccccgtgacc aagagcttca acaggggcga gtgctga       657


<210>  45
<211>  657
<212>  DNA
<213>  mus musculus

<400>  45
gacattgtga tgacccagtc tcccgatagc ctggccgtgt ccctgggcga gagggctacc     60

atcaactgta aaagctccga atctgtggac tcttacgcaa acagctttct gcactggtat    120

cagcaaaagc caggccaacc tccaaagctg ctgatttaca gggcttctac cagggagagc    180

ggcgtgcccg ataggttcag cggatctggc agcggcaccg actttacact gaccatctcc    240

agcctgcagg ccgaagatgt ggcagtctat tactgccagc agtccaagga ggaccccctg    300

actttcgggg gtggtactaa agtggagatc aagcgtacgg tggccgctcc cagcgtgttc    360

atcttccccc caagcgacga gcagctgaag agcggcaccg ccagcgtggt gtgtctgctg    420

aacaacttct accccaggga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc    480

ggcaacagcc aggagagcgt caccgagcag gacagcaagg actccaccta cagcctgagc    540

agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgtgaggtg    600

acccaccagg gcctgtccag ccccgtgacc aagagcttca acaggggcga gtgctga       657


<210>  46
<211>  118
<212>  PRT
<213>  mus musculus

<400>  46

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ile Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ser Leu Gly Glu Ser Leu Asp Trp Ile 
        35                  40                  45              


Gly Gly Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Leu Thr Val Ser Ser 
        115             


<210>  47
<211>  112
<212>  PRT
<213>  mus musculus

<400>  47

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Met Lys Arg 
            100                 105                 110         


<210>  48
<211>  354
<212>  DNA
<213>  mus musculus

<400>  48
gaggtccagc tgcagcagag cgggccagaa ctggttaaac ctggcgccag cgtgaagatt     60

agctgtaaga ccagcggtta catctttaca gcatatacca tgcactgggt gaggcagagt    120

ctgggggaat ctctggactg gatcggaggt attaagccca acaatggcct ggctaactat    180

aatcaaaaat tcaagggcaa agccacactg accgtcgata agtcctcttc cacagcttac    240

atggatctga gaagcctgac atccgaggac agtgcagtgt actactgcgc ccggtctgag    300

atcactaccg agttcgacta ttggggacag ggcactgcac tgaccgtctc ctcc          354


<210>  49
<211>  333
<212>  DNA
<213>  mus musculus

<400>  49
gatattgtgc tgacacagtc tcccgcaagc ctcgctgtta gcctgggtca acgggccaca     60

attagttgtc gcgcctctga atccgtcgac tcttatgcta acagctttat gcactggtat    120

caacagaagc ccgggcagcc acctaaactg ctgatctaca gggccagcaa tctggagagt    180

ggcatcccag ctagatttag cggttccggg tccaggaccg acttcactct gaccatcaac    240

cccgtggagg cagacgacgt ggccacttac tactgccagc agtctaaaga ggatcccctc    300

acattcggct ccggaacaaa gctggaaatg aag                                 333


<210>  50
<211>  443
<212>  PRT
<213>  mus musculus

<400>  50

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ile Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ser Leu Gly Glu Ser Leu Asp Trp Ile 
        35                  40                  45              


Gly Gly Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  51
<211>  446
<212>  PRT
<213>  mus musculus

<400>  51

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ile Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ser Leu Gly Glu Ser Leu Asp Trp Ile 
        35                  40                  45              


Gly Gly Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Cys His 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  52
<211>  218
<212>  PRT
<213>  mus musculus

<400>  52

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Met Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  53
<211>  1332
<212>  DNA
<213>  mus musculus

<400>  53
gaggtccagc tgcagcagag cgggccagaa ctggttaaac ctggcgccag cgtgaagatt     60

agctgtaaga ccagcggtta catctttaca gcatatacca tgcactgggt gaggcagagt    120

ctgggggaat ctctggactg gatcggaggt attaagccca acaatggcct ggctaactat    180

aatcaaaaat tcaagggcaa agccacactg accgtcgata agtcctcttc cacagcttac    240

atggatctga gaagcctgac atccgaggac agtgcagtgt actactgcgc ccggtctgag    300

atcactaccg agttcgacta ttggggacag ggcactgcac tgaccgtctc ctccgccagc    360

accaagggcc caagcgtgtt cccgctagcg ccctgctcca gaagcaccag cgagagcaca    420

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gtcctggaac    480

agcggagccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg    540

tacagcctga gcagcgtggt gaccgtgcca agcagcaact tcggcaccca gacctacacc    600

tgtaacgtgg accacaagcc cagcaacacc aaggtggaca agaccgtgga gaggaagtgc    660

tgtgtggagt gccccccctg cccagccccc ccagtggccg gacccagcgt gttcctgttc    720

ccccccaagc ccaaggacac cctgatgatc agcagaaccc ccgaggtgac ctgtgtggtg    780

gtggacgtgt cccacgagga ccccgaggtg cagttcaact ggtacgtgga cggcgtggag    840

gtgcacaacg ccaagaccaa gcccagagag gagcagttta acagcacctt ccgggtggtg    900

tccgtgctga ccgtggtgca ccaggactgg ctgaacggca aggagtacaa gtgtaaggtc    960

tccaacaagg gcctgccagc ccccatcgaa aagaccatca gcaagaccaa gggacagcca   1020

agagagccac aggtctacac cctgcccccc agcagggagg agatgaccaa gaaccaggtg   1080

tccctgacct gtctggtgaa gggcttctac ccaagcgaca tcgccgtgga gtgggagagc   1140

aacggccagc ccgagaacaa ctacaagacc acccccccaa tgctggacag cgacggcagc   1200

ttcttcctgt acagcaagct gacagtggac aagagcagat ggcagcaggg caacgtgttc   1260

agctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagag cctgagcctg   1320

tccccaggct ga                                                       1332


<210>  54
<211>  1341
<212>  DNA
<213>  mus musculus

<400>  54
gaggtccagc tgcagcagag cgggccagaa ctggttaaac ctggcgccag cgtgaagatt     60

agctgtaaga ccagcggtta catctttaca gcatatacca tgcactgggt gaggcagagt    120

ctgggggaat ctctggactg gatcggaggt attaagccca acaatggcct ggctaactat    180

aatcaaaaat tcaagggcaa agccacactg accgtcgata agtcctcttc cacagcttac    240

atggatctga gaagcctgac atccgaggac agtgcagtgt actactgcgc ccggtctgag    300

atcactaccg agttcgacta ttggggacag ggcactgcac tgaccgtctc ctccgccagc    360

accaagggcc caagcgtgtt cccgctagcc ccgtcttcaa agagtacctc aggcggaact    420

gccgctcttg gttgccttgt gaaggactat tttcctgagc ccgtgacggt cagctggaac    480

tctggcgcac tgactagcgg cgtacacaca ttccctgcgg tgctccaaag ttccgggctg    540

tactcactgt cctccgttgt gaccgttcca tctagttccc tcgggacaca gacatacatc    600

tgtaatgtga atcataagcc ttcaaacacc aaggtcgaca aacgggtcga gcccaaaagc    660

tgcgattgcc actgtcctcc atgtccagcc cccgaactgt tgggcggacc gagcgtgttc    720

ttgtttccac ccaagcccaa agataccctc atgatcagca gaacccccga ggtgacctgt    780

gtggtggtgg acgtgtccca cgaggaccca gaggtgaagt tcaactggta cgtggacggc    840

gtggaggtgc acaacgccaa gaccaagccc agagaggagc agtacaacag cacctacagg    900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgt    960

aaggtgtcca acaaggccct gccagcccca atcgaaaaga ccatcagcaa ggccaagggc   1020

cagccaagag agccccaggt gtacaccctg ccacccagca gggaggagat gaccaagaac   1080

caggtgtccc tgacctgtct ggtgaagggc ttctacccaa gcgacatcgc cgtggagtgg   1140

gagagcaacg gccagcccga gaacaactac aagaccaccc ccccagtgct ggacagcgac   1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac   1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcctg   1320

agcctgtccc caggcaagtg a                                             1341


<210>  55
<211>  657
<212>  DNA
<213>  mus musculus

<400>  55
gatattgtgc tgacacagtc tcccgcaagc ctcgctgtta gcctgggtca acgggccaca     60

attagttgtc gcgcctctga atccgtcgac tcttatgcta acagctttat gcactggtat    120

caacagaagc ccgggcagcc acctaaactg ctgatctaca gggccagcaa tctggagagt    180

ggcatcccag ctagatttag cggttccggg tccaggaccg acttcactct gaccatcaac    240

cccgtggagg cagacgacgt ggccacttac tactgccagc agtctaaaga ggatcccctc    300

acattcggct ccggaacaaa gctggaaatg aagcgtacgg tggccgctcc cagcgtgttc    360

atcttccccc caagcgacga gcagctgaag agcggcaccg ccagcgtggt gtgtctgctg    420

aacaacttct accccaggga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc    480

ggcaacagcc aggagagcgt caccgagcag gacagcaagg actccaccta cagcctgagc    540

agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgtgaggtg    600

acccaccagg gcctgtccag ccccgtgacc aagagcttca acaggggcga gtgctga       657




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