
                                SEQUENCE LISTING

<110> Glaxo Group Limited
      Enever, Carolyn
      Jespers, Laurent
      Pupecka, Malgorzata
      Tomlinson, Ian

<120> Methods for selecting protease resistant
  polypeptides

<130> DB00064WO

<150> 61/120,135          
<151> 2008-12-05  

<160> 23

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1155
<212> DNA
<213> Artificial Sequence

<400> 1
atggccggcg cccccggccc gctgcgcctt gcgctgctgc tgctcgggat ggtgggcagg 60
gccggccccc gcccccaggg tgccactgtg tccctctggg agacggtgca gaaatggcga 120
gaataccgac gccagtgcca gcgctccctg actgaggatc cacctcctgc cacagacttg 180
ttctgcaacc ggaccttcga tgaatacgcc tgctggccag atggggagcc aggctcgttc 240
gtgaatgtca gctgcccctg gtacctgccc tgggccagca gtgtgccgca gggccacgtg 300
taccggttct gcacagctga aggcctctgg ctgcagaagg acaactccag cctgccctgg 360
agggacttgt cggagtgcga ggagtccaag cgaggggaga gaagctcccc ggaggagcag 420
ctcctgttcc tcaagcttga gcccaaatcg gccgacaaaa ctcacacatc accaccgtca 480
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 540
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 600
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 660
aagccgcggg aggagcagta caacagcacg taccgggtgg tcagcgtcct caccgtcctg 720
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 780
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 840
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 900
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 960
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 1020
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 1080
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaacatcac 1140
catcatcatc actga                                                  1155

<210> 2
<211> 384
<212> PRT
<213> Artificial Sequence

<220> 

<400> 2
Met Ala Gly Ala Pro Gly Pro Leu Arg Leu Ala Leu Leu Leu Leu Gly
 1               5                  10                  15      
Met Val Gly Arg Ala Gly Pro Arg Pro Gln Gly Ala Thr Val Ser Leu
            20                  25                  30          
Trp Glu Thr Val Gln Lys Trp Arg Glu Tyr Arg Arg Gln Cys Gln Arg
        35                  40                  45              
Ser Leu Thr Glu Asp Pro Pro Pro Ala Thr Asp Leu Phe Cys Asn Arg
    50                  55                  60                  
Thr Phe Asp Glu Tyr Ala Cys Trp Pro Asp Gly Glu Pro Gly Ser Phe
65                  70                  75                  80  
Val Asn Val Ser Cys Pro Trp Tyr Leu Pro Trp Ala Ser Ser Val Pro
                85                  90                  95      
Gln Gly His Val Tyr Arg Phe Cys Thr Ala Glu Gly Leu Trp Leu Gln
            100                 105                 110         
Lys Asp Asn Ser Ser Leu Pro Trp Arg Asp Leu Ser Glu Cys Glu Glu
        115                 120                 125             
Ser Lys Arg Gly Glu Arg Ser Ser Pro Glu Glu Gln Leu Leu Phe Leu
    130                 135                 140                 
Lys Leu Glu Pro Lys Ser Ala Asp Lys Thr His Thr Ser Pro Pro Ser
145                 150                 155                 160 
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
                165                 170                 175     
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            180                 185                 190         
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
        195                 200                 205             
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
    210                 215                 220                 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
225                 230                 235                 240 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                245                 250                 255     
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
            260                 265                 270         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
        275                 280                 285             
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    290                 295                 300                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
305                 310                 315                 320 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                325                 330                 335     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
            340                 345                 350         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
        355                 360                 365             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His His His
    370                 375                 380                 


<210> 3
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 

<400> 3
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly
            20                  25                  30      


<210> 4
<211> 93
<212> DNA
<213> Artificial Sequence

<220> 

<400> 4
catggtgaag ggacctttac cagtgatgta agttcttatt tggaaggcca agctgccaag 60
gaattcattg cttggctggt gaaaggccga gga                              93

<210> 5
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 

<400> 5
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ser Gln
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Ala Ala Leu Pro Arg
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 6
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 

<400> 6
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gtggattggg tctcagttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcatgtgg cgttcctcgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgctcag ggtgcggcgt tgcctaggac gttcggccaa 300
gggaccaagg tggaaatcaa acgg                                        324

<210> 7
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 

<400> 7
Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys
 1               5                  10                  15      
Glu Leu Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu
            20                  25                  30          
Ala Ala Ala Lys Glu Leu Ala Ala
        35                  40  


<210> 8
<211> 120
<212> DNA
<213> Artificial Sequence

<220> 

<400> 8
aaagaagcgg cggcgaaaga agcggcggcg aaagaagcgg cggcgaaaga attggccgca 60
aaagaagcgg cggcgaaaga agcggcggcg aaagaagcgg cggcgaaaga attggccgca 120


<210> 9
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 

<400> 9
Pro Ser Ser
 1          


<210> 10
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 

<400> 10
ccaagctcg                                                         9

<210> 11
<211> 149
<212> PRT
<213> Artificial Sequence

<220> 

<400> 11
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Ser Glu Glu
 1               5                  10                  15      
Ala Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Lys
            20                  25                  30          
Glu Ala Ala Ala Lys Glu Leu Ala Ala Asp Ile Gln Met Thr Gln Ser
        35                  40                  45              
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
    50                  55                  60                  
Arg Ala Ser Gln Trp Ile Gly Ser Gln Leu Ser Trp Tyr Gln Gln Lys
65                  70                  75                  80  
Pro Gly Lys Ala Pro Lys Leu Leu Ile Met Trp Arg Ser Ser Leu Gln
                85                  90                  95      
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
            100                 105                 110         
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
        115                 120                 125             
Cys Ala Gln Gly Ala Ala Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys
    130                 135                 140                 
Val Glu Ile Lys Trp
145                 


<210> 12
<211> 149
<212> PRT
<213> Artificial Sequence

<220> 

<400> 12
His Gly Glu Gly Thr Phe Thr Ser Asp Gly Ala Asp Leu Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Lys
            20                  25                  30          
Glu Ala Ala Ala Lys Glu Leu Ala Ala Asp Ile Gln Met Thr Gln Ser
        35                  40                  45              
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
    50                  55                  60                  
Arg Ala Ser Gln Trp Ile Gly Ser Gln Leu Ser Trp Tyr Gln Gln Lys
65                  70                  75                  80  
Pro Gly Lys Ala Pro Lys Leu Leu Ile Met Trp Arg Ser Ser Leu Gln
                85                  90                  95      
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
            100                 105                 110         
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
        115                 120                 125             
Cys Ala Gln Gly Ala Ala Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys
    130                 135                 140                 
Val Glu Ile Lys Arg
145                 


<210> 13
<211> 159
<212> PRT
<213> Artificial Sequence

<220> 

<400> 13
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ala Thr Ala Cys Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Cys Leu Val Lys Gly Arg Gly Lys
            20                  25                  30          
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu
        35                  40                  45              
Leu Ala Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
    50                  55                  60                  
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile
65                  70                  75                  80  
Gly Ser Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                85                  90                  95      
Leu Leu Ile Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg
            100                 105                 110         
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
        115                 120                 125             
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Ala Ala
    130                 135                 140                 
Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
145                 150                 155                 


<210> 14
<211> 154
<212> PRT
<213> Artificial Sequence

<220> 

<400> 14
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Thr Gly Leu Glu Arg
            20                  25                  30          
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Leu Ala Ala Asp Ile
        35                  40                  45              
Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
    50                  55                  60                  
Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ser Gln Leu Ser
65                  70                  75                  80  
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Met Trp
                85                  90                  95      
Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
            100                 105                 110         
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
        115                 120                 125             
Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Ala Ala Leu Pro Arg Thr Phe
    130                 135                 140                 
Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
145                 150                 


<210> 15
<211> 147
<212> PRT
<213> Artificial Sequence

<220> 

<400> 15
His Gly Glu Gly Thr Phe Thr Ser Glu Phe Val Thr Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Lys Glu Ala
            20                  25                  30          
Ala Ala Lys Glu Leu Ala Ala Asp Ile Gln Met Thr Gln Ser Pro Ser
        35                  40                  45              
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
    50                  55                  60                  
Ser Gln Trp Ile Gly Ser Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly
65                  70                  75                  80  
Lys Ala Pro Lys Leu Leu Ile Met Trp Arg Ser Ser Leu Gln Ser Gly
                85                  90                  95      
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
            100                 105                 110         
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala
        115                 120                 125             
Gln Gly Ala Ala Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu
    130                 135                 140                 
Ile Lys Trp
145         


<210> 16
<211> 142
<212> PRT
<213> Artificial Sequence

<220> 

<400> 16
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Asp Leu Val Glu Gly Arg Gly Pro
            20                  25                  30          
Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
        35                  40                  45              
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly
    50                  55                  60                  
Ser Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
65                  70                  75                  80  
Leu Ile Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe
                85                  90                  95      
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
            100                 105                 110         
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Ala Ala Leu
        115                 120                 125             
Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
    130                 135                 140         


<210> 17
<211> 142
<212> PRT
<213> Artificial Sequence

<220> 

<400> 17
His Gly Glu Gly Thr Phe Thr Ser Glu Phe Val Thr Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Pro
            20                  25                  30          
Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
        35                  40                  45              
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly
    50                  55                  60                  
Ser Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
65                  70                  75                  80  
Leu Ile Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe
                85                  90                  95      
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
            100                 105                 110         
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Ala Ala Leu
        115                 120                 125             
Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
    130                 135                 140         


<210> 18
<211> 142
<212> PRT
<213> Artificial Sequence

<400> 18
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Met Thr Ser Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Pro
            20                  25                  30          
Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
        35                  40                  45              
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly
    50                  55                  60                  
Ser Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
65                  70                  75                  80  
Leu Ile Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe
                85                  90                  95      
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
            100                 105                 110         
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Ala Ala Leu
        115                 120                 125             
Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
    130                 135                 140         


<210> 19
<211> 142
<212> PRT
<213> Artificial Sequence

<400> 19
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Thr Gly Leu Glu Pro
            20                  25                  30          
Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
        35                  40                  45              
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly
    50                  55                  60                  
Ser Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
65                  70                  75                  80  
Leu Ile Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe
                85                  90                  95      
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
            100                 105                 110         
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Ala Ala Leu
        115                 120                 125             
Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
    130                 135                 140         


<210> 20
<211> 142
<212> PRT
<213> Artificial Sequence

<400> 20
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Ser Glu Phe Ile Ala Trp Leu Val Val Asp Gly Gly Pro
            20                  25                  30          
Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
        35                  40                  45              
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly
    50                  55                  60                  
Ser Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
65                  70                  75                  80  
Leu Ile Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe
                85                  90                  95      
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
            100                 105                 110         
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Ala Ala Leu
        115                 120                 125             
Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
    130                 135                 140         


<210> 21
<211> 142
<212> PRT
<213> Artificial Sequence

<400> 21
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Asp Leu Val Glu Gly Arg Gly Pro
            20                  25                  30          
Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
        35                  40                  45              
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly
    50                  55                  60                  
Ser Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
65                  70                  75                  80  
Leu Ile Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe
                85                  90                  95      
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
            100                 105                 110         
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Leu Arg His
        115                 120                 125             
Pro Lys Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
    130                 135                 140         


<210> 22
<211> 108
<212> PRT
<213> Artificial Sequence

<400> 22
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ser Gln
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Leu Arg His Pro Lys
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 23
<211> 324
<212> DNA
<213> Artificial Sequence

<400> 23
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gtggattggg tctcagttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcatgtgg cgttcctcgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgctcag ggtttgaggc atcctaagac gttcggccaa 300
gggaccaagg tggaaatcaa acgg                                        324
